trabeculectomy + mmc audit
DESCRIPTION
Trabeculectomy + MMC Audit. Mark Chiang, Clinical Research Fellow Mr. Peter Shah, Consultant Ophthalmic Surgeon Good Hope Hospital. Aim. To assess success and complication rates of trabeculectomies augmented with mitomycin C To compare results to the National Trabeculectomy Survey - PowerPoint PPT PresentationTRANSCRIPT
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Trabeculectomy + MMCTrabeculectomy + MMCAuditAudit
Mark Chiang, Clinical Research Fellow
Mr. Peter Shah, Consultant Ophthalmic Surgeon
Good Hope Hospital
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Aim
• To assess success and complication rates of trabeculectomies augmented with mitomycin C
• To compare results to the National Trabeculectomy Survey
• To define the characteristics of patients undergoing trabeculectomy with MMC
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Methods
• Prospective database of consecutive patients undergoing trabeculectomy + MMC under care of Mr. Peter Shah
• Data collected• Demographics• Pre-operative, operative and follow-up data
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Results
• Total number of eyes = 123Total number of eyes = 123
• Note retrieval 100%Note retrieval 100%
• 2004 Data update 99%2004 Data update 99%
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Gender
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Age at surgery
• Mean age = 55.6 years
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Ethnicity
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Glaucoma type
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Pre-op medications
• Average no. of drops = 2.65 (36.6% on Diamox)
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Surgeons
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Intraocular pressures(pre-operative)
HTG (108 eyes) NTG (15 eyes)
Mean pre-op highest IOP
38.0 mmHg 18.5 mmHg
Mean pre-op IOP
24.1 mmHg 15.7 mmHg
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Intraocular pressures(post-operative)
HTG NTG
Mean IOP
(1 year)
12.9 mmHg 11.3 mmHg
% IOP drop
(1 year)
46.5% 28.0%
Mean IOP (latest follow-up)
13.0 mmHg 10.6 mmHg
% IOP drop (latest follow-up)
46.1% 32.5%
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IOP distribution (1 year)
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Overall success(latest follow-up – mean 613 days)
HTG (106 eyes) NTG (14 eyes)
IOP ≤ 21 97.2%
IOP ≤ 17 87.7% 100%
IOP ≤ 14 70.8% 100%
IOP reduction > 30%
71.7% 57.1%
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Success by ethnicity(1 year)
AFC (23) Caucasian (59)
IOP ≤ 21 91.3% (78.3%) 98.3%
IOP ≤ 17 82.6% (78.3%) 94.9%
IOP ≤ 14 60.9% 86.4%
IOP reduction > 30%
65.2% 78.0%
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Success by previous surgery (1 year)
None (58) Intraocular (24)
IOP ≤ 21 98.3% (96.6%) 91.7% (90.9%)
IOP ≤ 17 98.3% (96.6%) 75%
IOP ≤ 14 89.7% 54.2%
IOP reduction > 30%
75.9% 70.8%
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Bleb morphology (1 year)
• Excellent bleb morphology 75.0%
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Bleb morphology (1 year)
• Satisfactory morphology 21.4%
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Bleb morphology (1 year)
• Poor morphology 3.6%
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Bleb Needling Revision
• 13.8% of patients (17/123)• 64.7% males• Mean pre-op highest IOP 40.7 mmHg • 47.1% on Diamox pre-operatively • 47.1% had previous intraocular surgery • 41.2% required topical drops at latest
follow-up• 35.3% African-Caribbean
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Post-op management
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Complications
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Clinically Significant Early Hypotony (CSEH)
• 4.9% of patients
• Required intervention• Viscoelastic to AC• Conjunctival / scleral flap suturing
• Analysis of CSEH reveals:• 33.3% AFC • 66.7% < 45 years of age
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Follow-up failures (DNA)
• DNA in 6 patients during follow-up• 4 African-Caribbean• 2 Caucasian – 1 alcoholic / 1 psychiatric• 5 males• Mean age 45.7 years old
• Age < 45• Male• African-Caribbean ethnicity
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Surgery technique
• Fornix based conjunctival flap• Wide sub-Tenons treatment with
MMC (0.1 – 0.2 mg/ml for 1 – 3 mins)• Pre-placed, buried, releasable ±
adjustable scleral flap sutures • Intra-op IOP titration• Buried purse-string & mattress
closure of conjunctiva and Tenons
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Conclusion
• High success rates for this series• Low complication rates for this
series• Results exceed National
Trabeculectomy Survey• Complications are more common in
African-Caribbean patients and in young patients
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Summary
• Success 97.2%
• Sight threatening complications 0.8%• 0 Wipe-out• 0 Endophthalmitis• 0 Suprachoroidal haemorrhage• 1 Late hypotony
• Clinically Significant Early Hypotony
(requiring intervention) 4.9%
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National Trabeculectomy Survey
• Success, IOP < 21 – 92%
• Complications• Hypotony – 24.3%• Hypotony maculopathy – 0.2%• Endophthalmitis – 0.3%• Wipe-out – 0.4% of total cohort, 5% in
advanced glaucoma• Cataract needing extraction – 2.5%
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Other series
• Success – 80 – 90%• Complications
• Hypotony – 4.8 – 47%• Hypotony maculopathy – 4 – 12%• Blebitis – 2 – 5.7%• Endophthalmitis – 0.8 – 8%• Wipe-out – 25% in one series• Cataract needing operation during follow-up
– 12 – 55%
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BUT!!BUT!!
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It’s only possible withIt’s only possible with
• Good pre-operative, peri-operative and intensive post-operative care
• Good success with lower doses of MMC but 34% post-op 5-FU and 14% bleb needling revision
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• Trabeculectomy with MMC is a complex operation requiring high degree of manual dexterity and extensive glaucoma experience
• Suggest Fellowship training for all surgeons performing this operation
• With close Consultant supervision, high success rates for Fellows in training
Discussion points
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Actions
• Continue long-term analysis of series• Target African-Caribbean and JOAG
patients for intensive intervention• Improve patient information• Consider glaucoma support nurse
help• These results only possible with
continued Fellow support
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Pearls
• Identify thin tissues pre-op• Small peritomy• Stromal hydration• Careful closure• ? No MMC
• Thin Tissues + Leak = Early Failure
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• In AFC / thick tissues need early
(<10 days) high flow into sub-Tenon space
• May need to remove both releasables
Pearls
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• Thin conj and Tenons – need thick scleral flap to control aqueous outflow
Pearls
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• JOAGs get hypotony
• Need early surgical intervention
• Beware of the young!
Pearls
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