training and career development charlotte a. pratt, phd program director division of prevention and...
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Training and Training and Career DevelopmentCareer Development
Charlotte A. Pratt, PhD
Program Director
Division of Prevention and Population Science
National Heart, Lung, and Blood Institute
OverviewOverview
• Career TimelineCareer Timeline• Grant mechanismsGrant mechanisms
– TrainingTraining– Career DevelopmentCareer Development
• Success RatesSuccess Rates• Loan Repayment ProgramLoan Repayment Program• SummarySummary• Additional ResourcesAdditional Resources
Spectrum of Training/Career Development Spectrum of Training/Career Development Opportunities through NHLBIOpportunities through NHLBI
HSHS
&&
ColleCollegege
GraduGraduateate
&&
MedicMedical al
SchoolSchool
Post graduate Post graduate FellowshipsFellowships
Transition to Transition to
Established Established InvestigatorInvestigator
(Jr. Faculty)(Jr. Faculty)
EstablishEstablished ed
InvestigaInvestigatortor
MARC MARC U*STARU*STAR
UndergraUndergradsds
BRTPUGBRTPUG
ProgramProgram
UndergraUndergrads, post-ds, post-bac, &bac, &
graduategraduates s
T35 T35
UndergraUndergradsds
BRTPUG BRTPUG ProgramProgram
T32T32
T32 T32
Minority Minority institutionsinstitutions
F31F31
Minority Minority students & students & individuals individuals with with disabilitiesdisabilities
T35 T35
Minority Minority studentsstudents
F32 Individual F32 Individual award award
T32 Institutional T32 Institutional awardaward
T32 Minority T32 Minority institution awardinstitution award
K08K08
K23K23
K25K25
K22K22
K01 Minority K01 Minority facultyfaculty
K01 Minority K01 Minority institutioninstitution
K99/R00K99/R00
R mechanismsR mechanisms
K24K24
K25K25
R-R-mechanismechanis
ms ms
F33F33
Senior Fellowships
(F33)
IndependentInvestigatorInternship/Residency
Specialty
MedicalSchool
Postdoctoral Fellowships
(F32)
Awards for Individuals with a Health-Professional Doctorate
InstitutionalTraining Grants (T32)
Midcareer Investigatorin Patient-Oriented
Research (K24)
Mentored Patient-Oriented Research CDA (K23)
Scientist Development Program (K12)
Mentored Clinical Scientist Development Award (K08)
Short-TermTraining Grant(T35)
Career Enhancement Award Stem Cells (K18)
Senior Fellowships
(F33)
Career Transition
Award (K22)
Mentored Research Scientist
Development Award (K01)
IndependentScientist Award (K02)
PostdoctoralGraduate School & Medical School
Coll.
Postdoctoral Fellowships
(F32)
Predoctoral Fellowships (F31)
Awards for Individuals with a Research DoctorateInstitutional
Training Grants (T32)
IndependentInvestigator
MARCCOR (T34)
Career Enhancement Award Stem Cells (K18)
BRTPUGProgramUndergrads, post-bac, &graduates
T35 Undergrads
NHLBI Early Career Development NHLBI Early Career Development Awards Awards
(Individual K Awards)(Individual K Awards)Overall goal: Overall goal:
To transition junior faculty into successful R01 To transition junior faculty into successful R01 investigators investigators
Individual awardsIndividual awards
Provides salary support to 75% for protected research Provides salary support to 75% for protected research timetime
Support for research expenses, coursework, books, Support for research expenses, coursework, books, traveltravel
Evaluated based on the qualifications of the applicant, Evaluated based on the qualifications of the applicant, mentoring team, institutional resources, education & mentoring team, institutional resources, education &
research planresearch plan
Mentoring team critical to successMentoring team critical to success
Awardee encouraged to apply for R01 in year 4-5Awardee encouraged to apply for R01 in year 4-5
Awards For New Awards For New ResearchersResearchers
• Mentored Clinical Scientist Development Mentored Clinical Scientist Development Award (K08)Award (K08)
• Mentored Patient-Oriented Research Career Mentored Patient-Oriented Research Career Development Award (K23)Development Award (K23)
• NIH Pathway to Independence (PI) AwardNIH Pathway to Independence (PI) Award(K99/R00)(K99/R00)
• Independent Scientist Award (K02)Independent Scientist Award (K02)
• Career Transition Award (K22) Career Transition Award (K22)
• Mentored Quantitative Research Career Mentored Quantitative Research Career Development Award (K25) Development Award (K25)
Mentored Clinical Mentored Clinical Scientist Development Scientist Development
Award (K08)Award (K08)
• Applicants: Applicants: Clinicians who are interested Clinicians who are interested in developing independent research careers.in developing independent research careers.
• Application deadlines: Application deadlines: February 1, June 1, February 1, June 1, and October 1.and October 1.
• Requirements:Requirements: at least 75% effort. at least 75% effort.
• Support:Support: 3-5 years. 3-5 years.
• Salary: Salary: Up to $75,000 per year plus Up to $75,000 per year plus benefits and up to benefits and up to $25,000$25,000 per year for per year for research development support.research development support.
Mentored Patient-Oriented Mentored Patient-Oriented Research Career Research Career
Development Award (K23)Development Award (K23)
• Applicants: Applicants: Scientists who are committed to Scientists who are committed to developing careers in patient-oriented developing careers in patient-oriented research.research.
• Application deadlines: Application deadlines: February 1, June 1, February 1, June 1, and October 1.and October 1.
• Requirements:Requirements: at least 75% effort. at least 75% effort.
• Support:Support: 3-5 years. 3-5 years.
• Salary: Salary: Up to $75,000 per year plus benefits Up to $75,000 per year plus benefits and up to and up to $50,000$50,000 per year for research per year for research development support.development support.
Facts About K08 and K23Facts About K08 and K23
Similarities -Similarities -• Mentored awardsMentored awards• Faculty appointment not required Faculty appointment not required • Require Require >> 75% effort 75% effort• 3 – 5 years of support3 – 5 years of support• Budgets similarBudgets similar
– Salary levels may vary by Salary levels may vary by instituteinstitute
Facts About K08 and K23Facts About K08 and K23
Differences -Differences -• Research Development Support -Research Development Support -
$25,000/year for K08$25,000/year for K08
up to $50,000/year for K23up to $50,000/year for K23• K23 candidates must take courses such as K23 candidates must take courses such as
study design, biostatistics, epidemiology, study design, biostatistics, epidemiology, data management, hypothesis data management, hypothesis development, drug development, etc., and development, drug development, etc., and legal and ethical issues associated with legal and ethical issues associated with human subjects researchhuman subjects research
What is “Patient-Oriented What is “Patient-Oriented Research”?Research”?
For purposes of K23 award –For purposes of K23 award – Research conducted with human subjects Research conducted with human subjects
(or on material of human origin such as (or on material of human origin such as tissues, specimens, and cognitive tissues, specimens, and cognitive phenomena) for which an investigator phenomena) for which an investigator directly interacts with human subjects.directly interacts with human subjects.
This includes:This includes:• mechanisms of human diseasemechanisms of human disease• therapeutic and behavioral interventionstherapeutic and behavioral interventions• clinical trialsclinical trials• development of new technologiesdevelopment of new technologies
What Doesn’t Count as What Doesn’t Count as Patient-Oriented Research?Patient-Oriented Research?
• Analysis of existing databasesAnalysis of existing databases• Brief interaction with human subjects Brief interaction with human subjects
(such as one blood draw)(such as one blood draw)• Candidate designs a questionnaire that Candidate designs a questionnaire that
will be administered by other staffwill be administered by other staff
The projects listed above would be appropriate for a K08
application
NIH “Clinical Research” NIH “Clinical Research” DefinitionDefinition
Clinical research is defined in three parts as Clinical research is defined in three parts as follows: follows:
(1) Research conducted with human subjects (or on (1) Research conducted with human subjects (or on material of human origin such as tissues, specimens, material of human origin such as tissues, specimens, and cognitive phenomena) for which an investigator and cognitive phenomena) for which an investigator (or colleague) directly interacts with human (or colleague) directly interacts with human subjects. Excluded from this definition are in vitro subjects. Excluded from this definition are in vitro studies that utilize human tissues that cannot be studies that utilize human tissues that cannot be linked to a living individual. Patient-oriented linked to a living individual. Patient-oriented research includes: (a) mechanisms of human research includes: (a) mechanisms of human disease, (b) therapeutic interventions, (c) clinical disease, (b) therapeutic interventions, (c) clinical trials, and (d) development of new technologies, trials, and (d) development of new technologies,
(2) Epidemiologic and behavioral studies, (2) Epidemiologic and behavioral studies,
(3) Outcomes research and health services research. (3) Outcomes research and health services research.
PA-06-133PA-06-133NIH Pathway to Independence (PI) NIH Pathway to Independence (PI)
AwardAward(K99/R00)(K99/R00)
• Release date: 1/27/2006Release date: 1/27/2006• Letter of Intent: Not requiredLetter of Intent: Not required• First receipt date: April 7, 2006First receipt date: April 7, 2006• Subsequent receipt dates: Subsequent receipt dates:
Standard NIH deadlinesStandard NIH deadlines• Announcement atAnnouncement at
http://grants.nih.gov/grants/guide/-a-files/PA-06-133.htmlhttp://grants.nih.gov/grants/guide/-a-files/PA-06-133.html
K99/R00K99/R00
• Up to 5 years support, two phasesUp to 5 years support, two phases• Phase I Mentored research, 1-2 years Phase I Mentored research, 1-2 years
(K00)(K00)• Phase II Independent research support Phase II Independent research support
(R00) 1-3 years, contingent on securing (R00) 1-3 years, contingent on securing an independent research/faculty positionan independent research/faculty position
• Each phase provides funds for salary & Each phase provides funds for salary & research costsresearch costs
K99/R00 Applicant K99/R00 Applicant RequirementsRequirements
• Outstanding postdoctoral candidates who Outstanding postdoctoral candidates who have terminal clinical or research doctorates have terminal clinical or research doctorates (PhD, MD, DO, DDS, DVM, ScD, DNS)(PhD, MD, DO, DDS, DVM, ScD, DNS)
• No more than 5 years postdoctoral research No more than 5 years postdoctoral research trainingtraining
• US citizens & non-US citizensUS citizens & non-US citizens• May submit only one PI Award applicationMay submit only one PI Award application• May not simultaneously submit applications May not simultaneously submit applications
or have pending awards for any other PHS or have pending awards for any other PHS career development award (no K awards)career development award (no K awards)
K99/R00 AwardK99/R00 Award• Salary-Phase ISalary-Phase I Mentored research (K00):Mentored research (K00): up to up to
$50,000, plus applicable fringe benefits; up to $20,000 $50,000, plus applicable fringe benefits; up to $20,000 for research support/year. Total cost up to $90,000; may for research support/year. Total cost up to $90,000; may engage in teaching and/or clinical duties up to 25% engage in teaching and/or clinical duties up to 25% efforteffort
• Salary-Phase IISalary-Phase II Independent research support Independent research support (R00): (R00): Consistent with institution’s salary structure. Consistent with institution’s salary structure. Total cost up to $249,000/year.Total cost up to $249,000/year.
• Requirement:Requirement: minimum of 75% of full-time professional minimum of 75% of full-time professional ..
• Salary for mentor (K00):Salary for mentor (K00): May also request up to 5% May also request up to 5% of mentor’s salary plus benefits. of mentor’s salary plus benefits.
• Application deadline: Application deadline: 1212thth of March, July and of March, July and NovemberNovember
• http://grants.nih.gov/grants/funding/submissionschedule.htmhttp://grants.nih.gov/grants/funding/submissionschedule.htm
Independent Independent Scientist Award Scientist Award
(K02)(K02) Applicants: Applicants: Investigators at non-federal Investigators at non-federal
public or profit U.S. institutions engaged public or profit U.S. institutions engaged in health-related research. in health-related research.
Application deadlines: Application deadlines: February 1, February 1, June 1, and October 1.June 1, and October 1.
Requirement:Requirement: at least 75% effort. at least 75% effort.
Support:Support: 3-5 years 3-5 years
Salary: Salary: Up to $75,000 per year plus Up to $75,000 per year plus benefits. No other research development benefits. No other research development support funds are provided.support funds are provided.
Career Transition Award Career Transition Award (K22)(K22)
• How to apply: Individuals apply to the NIH.
Training SiteTraining Site SalarySalary
11 NHLBI NHLBI Intramural Intramural LabsLabs
Based on experience; 100% Based on experience; 100% effort; up to 3 yearseffort; up to 3 years
22 Extramural Extramural InstitutionInstitution
Up to $75,000 per year plus Up to $75,000 per year plus benefits, and up to $75,000 benefits, and up to $75,000 per year for research per year for research support; up to 75% effort; up support; up to 75% effort; up to 2 yearsto 2 years
• Application deadlines: February 1, June 1, and October 1.
Mentored Quantitative Mentored Quantitative Research Career Research Career
Development Award (K25)Development Award (K25)
• Applicants: Applicants: Individuals with an advanced degree in a quantitative area of science or engineering who are committed to careers as independent biomedical or behavioral investigators.
• Application deadlines: Application deadlines: February 1, June 1, October 1.
• Salary: Salary: Up to $75,000 per year plus benefits and up to $40,000 per year for research development support.
• Requirement: at least 75% effort.
• Support: 3-5 years
Awards For Minority Awards For Minority ScientistsScientists
Minority ResearchersMinority Researchers
• NHLBI Mentored Career Award for NHLBI Mentored Career Award for Faculty at Minority Institutions (K01)Faculty at Minority Institutions (K01)
• NHLBI Mentored Minority Faculty NHLBI Mentored Minority Faculty Development Award (K01)Development Award (K01)
• Research Supplements for Research Supplements for Underrepresented Minority InvestigatorsUnderrepresented Minority Investigators
Mentored Career Award forMentored Career Award forFaculty at Minority Institutions Faculty at Minority Institutions
(K01)(K01)• Applicants: Applicants: Minority Institutions apply on behalf of Minority Institutions apply on behalf of
faculty and students.faculty and students.
• Application deadline: Application deadline: Announced annually, July 19, Announced annually, July 19, 2005, 2006 and 2007. 2005, 2006 and 2007.
• Faculty Salary: Faculty Salary: Up to $75,000 per year plus Up to $75,000 per year plus benefits, and up to $36,000 per year for research benefits, and up to $36,000 per year for research support .support .
• Requirement:Requirement: 100% effort during summer; at least 100% effort during summer; at least 25% effort during academic year.25% effort during academic year.
• Salary:Salary: May also request up to 5% of mentor’s May also request up to 5% of mentor’s salary plus benefits.salary plus benefits.
– Student Salary: Student Salary: $10.00 per hour plus benefits $10.00 per hour plus benefits and a summer housing allowance.and a summer housing allowance.
• ApplicantsApplicants: Underrepresented minority : Underrepresented minority faculty members interested in cardiovascular, faculty members interested in cardiovascular, pulmonary, hematologic, or sleep disorders pulmonary, hematologic, or sleep disorders research. research.
• Application deadlineApplication deadline: Announced annually, : Announced annually, usually late August. usually late August.
• Requirement:Requirement: at least 75% effort. at least 75% effort.
• Support:Support: 3-5 years. 3-5 years.
• SalarySalary: Up to $75,000 per year plus : Up to $75,000 per year plus benefits, and up to $30,000 per year for benefits, and up to $30,000 per year for research supportresearch support..
NHLBI Mentored Minority FacultyNHLBI Mentored Minority FacultyDevelopment Award (K01)Development Award (K01)
Minority Investigator Minority Investigator Research SupplementsResearch Supplements
• Applicants:Applicants: Principal investigators with Principal investigators with eligible NHLBI grants apply on behalf of the eligible NHLBI grants apply on behalf of the minority junior faculty individual. minority junior faculty individual.
• Application deadline:Application deadline: At least 3 months At least 3 months before the requested start date.before the requested start date.
• Salary and benefitsSalary and benefits: Up to $75,000 per year : Up to $75,000 per year plus benefits.plus benefits.
• Requirement:Requirement: at least 75% effort. at least 75% effort.
• SupportSupport: 2-4 years.: 2-4 years.
• Supplies and travel:Supplies and travel: Up to $10,000 per year Up to $10,000 per year
• National Research Service Awards for Senior Fellows (F33)
• Mid-Career Investigator Award in Patient-Oriented Research Award (K24)
Established ResearchersEstablished Researchers
National Research Service National Research Service Awards for Senior Fellows Awards for Senior Fellows
(F33)(F33)
• Applicants: Experienced scientists with at least 7 years of relevant postdoctoral research or professional training who are interested in changing the direction of their careers.
• Application deadline: April 5, August 5, and December 5.
• Support: Full-time up to 2 years support
• Stipend: Up to $51,036 per year, plus an institutional allowance of $5,500 per year.
Mid-Career Investigator Award Mid-Career Investigator Award in Patient Oriented Research in Patient Oriented Research
(K24)(K24)
• Applicants: Established clinicians within 15 years of their specialty training.
• Application deadline: February 1, June 1, and October 1.
• Support: 3 to 5 years, 20 to 50 percent effort, with a one time renewal.
• Stipend: Up to $80,600 plus fringe benefits per year, and up to $25,000 for research development support.
NIH K Award DataNIH K Award Data
Number of NIH K AwardsFiscal Years 1994 - 2004
1,500
2,000
2,500
3,000
3,500
4,000
1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004
“Patient-Oriented Research” awards begin
Trends in Number of Individual K Awards by Institute or Center
Fiscal Years 1994 - 2004
0
100
200
300
400
500
600
Excludes K12, K16, and K17.
Trends in K08 Awards by InstituteFiscal Years 1994 - 2004
0
50
100
150
200
250
NIH Success Rates for Selected K Activities
Fiscal Years 1990 - 2004
0
10
20
30
40
50
60
70
1990 1992 1994 1996 1998 2000 2002 2004
Success Rate
K02
K08
K23
K24
K01
0
50
100
150
200
250
1995 1996 1997 1998 1999* 2000 2001 2002 2003 2004
Fiscal Year
# o
f A
pp
licat
ion
sK23K08
NHLBI K08 and K23 Applications
Fiscal Years 1995 - 2004
*Salary Cap increase, $50K – $75K; K23 begins
Loan Repayment Program for Loan Repayment Program for Extramural ScientistsExtramural Scientists
= LRP= LRP
Extramural NIH Loan Extramural NIH Loan Repayment ProgramRepayment Program
• Attract Health Professionals to res. CareersAttract Health Professionals to res. Careers• Must conduct qualified research at a non-Must conduct qualified research at a non-
profit institutionprofit institution• NHLBI Programs: Pediatric; Clinical; NHLBI Programs: Pediatric; Clinical;
Health DisparitiesHealth Disparities• Must be U.S. citizen or perm. residentMust be U.S. citizen or perm. resident• Debt must be Debt must be >> 20% of annual salary 20% of annual salary• Exchanges 2 year commitment for up to Exchanges 2 year commitment for up to
$70,000 repayment of your qualified $70,000 repayment of your qualified educational debteducational debt
• Termination by participant: $7,500/month Termination by participant: $7,500/month of unserved time plus all amounts paid on of unserved time plus all amounts paid on behalfbehalf
NHLBI Research Training NHLBI Research Training ContactsContacts
K08 – Mentored Clinical Scientist Development Award Ms. Lorraine Silsbee (301) 435-0707
K23 – Mentored Patient-Oriented Research Career Development Award (301) 435-0535
K02 – Independent Scientist AwardDr. Traci H. Mondoro (301) 435-0052
K22 - Career Transition AwardDr. Helena Mishoe (301) 435-5081
NHLBI Research Training NHLBI Research Training ContactsContacts
K24 – Mid-career Investigator Award in Patient-Oriented Research Dr. Ellen Werner (301) 435-0077
K25 – Mentored Quantitative Research Career Development Award Dr. Michael Commarato (301) 435-0052
K01 – Minority Faculty Development Award Ms. Lorraine Silsbee (301) 435-0707
K01 – Mentored Career Award for Faculty at Minority Institutions Dr. Traci H. Mondoro (301) 435-0052
F33 – National Research Service Award for Senior FellowsDr. Charlotte A. Pratt (301) 435-0382
SummarySummary
1.1. Contact NIH Program DirectorContact NIH Program Director
2.2. Work with mentor, collaboratorsWork with mentor, collaborators
3.3. Prepare applicationPrepare application
4.4. Solicit local reviewsSolicit local reviews
5.5. Submit applicationSubmit application
6.6. BeforeBefore review, contact SRA, if review, contact SRA, if necessarynecessary
7.7. AfterAfter review, contact Program review, contact Program
Additional Training Additional Training ResourcesResources
NHLBI Training & FundingNHLBI Training & Funding
www.nhlbi.nih.gov/funding/training/training/index.hwww.nhlbi.nih.gov/funding/training/training/index.htmtm
NIH Training OpportunitiesNIH Training Opportunities
http://grants1.nih.gov/training/extramural.htmhttp://grants1.nih.gov/training/extramural.htm
K KioskK Kiosk
http://grants1.nih.gov/training/careerdevelopment.hhttp://grants1.nih.gov/training/careerdevelopment.htmtm