transcription. bell ringer – 04/17 what is gene expression? information in genes is used to…
DESCRIPTION
Agenda Transcription Transcription practice problems Intro to translationTRANSCRIPT
TRANSCRIPTION
Bell Ringer – 04/17 What is Gene Expression? Information in genes is used to
build ___________.
Learning Target: We will describe the steps of transcription.Closure task: I will complete the Transcription Practice Problems
Agenda Transcription Transcription practice problems Intro to translation
Take notes on your handoutsGene Expression:
Stage 1: Stage 2:
Dinosaur DNA!As you watch the following video, answer the following:1. Where did the DNA for dinosaurs come
from?2. What parts of the video are true and
which parts are false?
Jurassic Park! https://
www.youtube.com/watch?v=mDTaykXudVI
Big Picture
DNA
Genes
Proteins
You!
Transcription video https://
www.youtube.com/watch?v=41_Ne5mS2ls
Transcription Definition: Annotate the image
Three steps of transcription1.
2.
3.
*Note:
Skip to the Key Vocabulary section Messenger RNA (mRNA):
DNA vs RNADNA RNA
Creating a mRNA sequence DNA A codes for RNA U DNA T codes for RNA A DNA G codes for RNA C DNA C codes for RNA G
DNA Sequence: A T T T G C G
mRNA Sequence: U A A A C G C
Find the mRNA sequence of the following DNA strand
T T A G C C A T G C
A A U C G G U A C G
The process of DNA RNA is called TRANSCRIPTION
Practice ProblemsUsing your knowledge of transcription, complete the practice problems.
TranslationDefinition:
Complete gene expressionTranscription & Translation https://
www.youtube.com/watch?v=zwibgNGe4aY
Key Vocabulary during Video: Codon: Ribosome: Ribosomal RNA (rRNA):
Translation specifics https://
www.youtube.com/watch?v=1PSwhTGFMxs
Key Vocabulary during Video:Transfer RNA (tRNA):
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
All 3 RNAs What are the three different types of RNA?
Exit Slip Compare replication to
transcription. What is the starting and ending
products? Where does it happen?
How did you do? Rate yourself!I can describe the stages of transcription.
I completed the Transcription Practice Problems.
TRANSLATION
DOO
R
PROJECTOR
FRONT TABLE
LAB TABLE
Period 1
LAB TABLE
LAB TABLE LAB TABLE
Lucas
Katherine
Markel
Zachary
Corie
Cheyenne
Blake
Nathanael
Gavin Miles
Robert
Jessica H.
Christian
Justin
AnnaArnoldo
Jessica P.
BrentKambria
Maria
Tyler
Deshawn
DOO
R
PROJECTOR
FRONT TABLE
LAB TABLE
Period 2
LAB TABLE
LAB TABLE LAB TABLE
Deja
Charles
Rosario
Havanaa
Steven
Shakira
Jesus
Daymontria
Natalie
Adrianne
ClaraAustin
Breonna
Michael
TylerHasret
Cheyenne
Gabriel
Vishawn
Chelsea
Raudel
DOO
R
PROJECTOR
FRONT TABLE
LAB TABLE
Period 4
LAB TABLE
LAB TABLE LAB TABLE
Dejon
TerresiaAlejandro
Herschel
Elizabeth
Donovan
Crescencia
Ariadne
Jacob
Brevin
Jonathan
Devin
John
Kaylah
Destiny
Mirrissa
Christian
DOO
R
PROJECTOR
FRONT TABLE
LAB TABLE
Period 5
LAB TABLE
LAB TABLE LAB TABLE
DaltonAndrew
JonathanGarrison Trenten
Le
Nick
Rehema
Ezra
Matthew
Phillip
Detarius
Amber
Sheyanne
John
David
Austin
Celest
Bell Ringer – 04/20
Learning Target: We will describe the steps of translation.Closure task: I will complete the Translation Practice Problems.
1. What are the starting and ending products of transcription?
2. What is the mRNA strand for the following DNA strand?
DNA: G G A T T C G A G T A A G CmRNA:
Agenda Steps of translation Foldable Mutations & Translation Translation practice
TranslationDefinition:
Complete gene expressionTranscription & Translation https://
www.youtube.com/watch?v=zwibgNGe4aY
Key Vocabulary during Video: Codon: Ribosome: Ribosomal RNA (rRNA):
Translation specifics https://
www.youtube.com/watch?v=1PSwhTGFMxs
OR http://www.pbslearningmedia.org/resourc
e/tdc02.sci.life.gen.proteinsynth/from-dna-to-protein/en/
Key Vocabulary during Video:Transfer RNA (tRNA):
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
DNA has the information for our cells to make proteins.
Copyright © 2010 Ryan P. Murphy
Keep yourhard copy safe in the
nucleus
All 3 RNAs What are the three different types of RNA?
Annotate the image! Annotate translation image
Step 1
Step 2
Step 3
Step 4
Four steps of translation
Step 1 - Ribosome attaches to the start codon (AUG) of mRNA.Step 2 - tRNAs (which carry amino acids) with anticodons that match the codons enter the ribosome as it moves down the mRNA.
Four steps of translation
Step 3 - The ribosome build a protein using the amino acids brought by the tRNAs.Step 4 - Ribosome reaches a stop codon, releasing the ribosome and completed protein!
OverviewDetails Replication Transcriptio
nTranslation
What we start with
DNA DNA mRNA
What we make
DNA mRNA Proteins
Where this happens
Nucleus Nucleus Cytoplasm
Why we care
We need accurate copies of our DNA in new cells
The link between DNA and proteins
We need to produce accurate proteins
How to read a codon chart mRNA: AUG GGA UAC CUC UGA
PracticeDNA: T T A C C A A G C CmRNA: A A U G G U U C G GCodons: AUG GUU CGGAmino Acids: Methionine Valine Arginine
Back to the foldable Take out the foldable that we
filled out before Follow along as we complete the
rest of the foldable. The inside should contain a mRNA
sequence and amino acid sequence
Complete the practice problems on the handout
Big Picture1 •Nucleotide order of gene
2 •Nucleotide order of mRNA
3 •Order of Amino Acids
4 •Protein Shape
5 •Protein Function
Back to mutationsWhat are the different types of mutations?
How do mutations affect the production of proteins? Changes in amino acid sequence = changes in protein shape
Why is translation important?
Original DNA
DNA: T T A C C A A G C C
mRNA: A A U G G U U C G G
Codons: AUG GUU CGG
Amino Acids: Methionine Valine Arginine
Mutated DNA
Original DNA: T T A C C A A G C CMutated DNA: T T A C C G A G C CmRNA: A A U G G C U C G GCodons: AUG GCU CGGAmino Acids: Methionine Alanine Arginine
Exit Slip
DNA: A T A C G T A A C CmRNA: Codons: Amino Acids:How did you do? Rate yourself!
I can describe the stages of translation.I completed the Translation Practice Problems.
DOO
R
PROJECTOR
FRONT TABLE
LAB TABLE
Period 1
LAB TABLE
LAB TABLE LAB TABLE
Lucas
Katherine
Markel
Zachary
Corie
Cheyenne
Blake
Nathanael
Gavin Miles
Robert
Jessica H.
Christian
Justin
AnnaArnoldo
Jessica P.
BrentKambria
Marie
Tyler
Deshawn
DOO
R
PROJECTOR
FRONT TABLE
LAB TABLE
Period 2
LAB TABLE
LAB TABLE LAB TABLE
Deja
Charles
Rosario
Havanaa
Steven
Shakira
Jesus
Daymontria
Natalie
Adrianne
ClaraAustin
Breonna
Michael
TylerHasret
Cheyenne
Gabriel
Vishawn
Chelsea
Raudel
DOO
R
PROJECTOR
FRONT TABLE
LAB TABLE
Period 4
LAB TABLE
LAB TABLE LAB TABLE
Dejon
TerresiaAlejandro
Herschel
Elizabeth
Donovan
Crescencia
Ariadne
Jacob
Brevin
Jonathan
Devin
John
Kaylah
Destiny
Mirrissa
Christian
DOO
R
PROJECTOR
FRONT TABLE
LAB TABLE
Period 5
LAB TABLE
LAB TABLE LAB TABLE
DaltonAndrew
JonathanGarrison Trenten
Le
Nick
Rehema
Ezra
Matthew
Phillip
Detarius
Amber
Sheyanne
John
David
Austin
Celest
Bell Ringer – 04/21
Learning Target: We will determine the effects of mutations on an amino acid sequence.
Closure task: I will ace the transcription & translation quiz!
1. Where does transcription occur? Where does translation occur?
2. What are three differences between DNA and RNA?
Quiz today!
Agenda Quick review Translation model Big picture Translation practice worksheet Mutations and translation Transcription & Translation quiz
Quick review of transcription & translation
http://www.pbslearningmedia.org/resource/lsps07.sci.life.stru.celltrans/cell-transcription-and-translation/
TranslationEach groups should have:
One mRNA strand Five tRNA molecules
Match up the appropriate tRNA to the mRNA
Translation modelUsing the codon chart, figure out what nucleotide each color represents.
Fill in the information below: Amino Acid: Codon: mRNA: DNA:
Back to the foldable Take out the foldable that we
filled out before Follow along as we complete the
rest of the foldable. The inside should contain a mRNA
sequence and amino acid sequence
Complete the practice problems on the handout
Big Picture1
2
3
4
5
Big Picture1 •Nucleotide order of gene
2
3
4
5
Big Picture1 •Nucleotide order of gene
2 •Nucleotide order of mRNA
3
4
5
Big Picture1 •Nucleotide order of gene
2 •Nucleotide order of mRNA
3 •Order of Amino Acids
4
5
Big Picture1 •Nucleotide order of gene
2 •Nucleotide order of mRNA
3 •Order of Amino Acids
4 •Protein Shape
5
Big Picture1 •Nucleotide order of gene
2 •Nucleotide order of mRNA
3 •Order of Amino Acids
4 •Protein Shape
5 •Protein Function
Back to mutationsWhat are the different types of mutations?
How do mutations affect the production of proteins? Changes in amino acid sequence = changes in protein shape
Why is translation important?
Mutations
Insertion
Silent mutation
Original DNA
DNA: T T A C C A A G C C
mRNA: A A U G G U U C G G
Codons: AUG GUU CGG
Amino Acids: Methionine Valine Arginine
Mutated DNA
Original DNA: T T A C C A A G C CMutated DNA: T T A C C G A G C CmRNA: A A U G G C U C G GCodons: AUG GCU CGGAmino Acids: Methionine Alanine Arginine
Complete Translation Exit Slip handout
Quick review Genes contain information to build proteins Proteins carry out important functions in the cell The protein that is expressed is determined by
the gene’s nucleotide sequence (A,C, T, G) Proteins are sequences of amino acids The order of nucleotides in a gene determines
the order of amino acids – the amino acid determines the protein’s shape which determines function
PROTEIN SHAPE DETERMINES PROTEIN FUNCTION
Transcription Occurs in nucleus Produces mRNA using a gene as a
template mRNA – RiboNucleic Acid
Contains the sugar Ribose Instead of Thymine – T, mRNA uses
Uracil – U mRNA is single stranded
Translation Occurs in the cytoplasmRibosomes read the mRNA stand and coordinate the addition of amino acids in the proper sequence.
Produces proteins
Genetic Information is first expressed as RNA
There are three types of RNA mRNA – messenger RNA carries
information from the nucleus to the cytoplasm where protein is made/translated
tRNA – transfer RNA – transfers amino acids to a protein .
rRNA – ribosomal RNA These RNA strands function in assembling
amino acids to make proteins
Intro to Gene Expression Poster You will be completing a poster that
demonstrates the harmful impacts of mutations.
Things you will need: Poster checklist Poster DNA sequence slip Need to know box on pg. 459 Poster template on pg. 460
Create a poster Create a poster comparing Normal alleles
with Sickle – cell alleles Your poster will need to include
Genotype DNA sequence mRNA sequence Polypeptide structure Shape of hemoglobin molecule Behavior of the hemoglobin molecule Shape of the red blood cell under low oxygen Medical implications
Exit SlipWhat effect does a DNA mutation have on the protein the cell makes?
What part (if any) of transcription and translation do you have trouble understanding?
How did you do? Rate yourself!We will determine the effects of mutations on
an amino acid sequenceI will ace the transcription & translation quiz!
TRANSCRIPTION & TRANSLATION QUIZ
Bell Ringer – 04/22
Learning Target: We will determine the effects of mutations on an amino acid sequence.Closure task: I will ace the transcription & translation quiz!
Fill in the blanks:1. During ___________ a mRNA is
created in the ________.2. The mRNA then travels into the
_________, where ________ occurs.3. _________ makes a chain of amino
acids as it moves down the mRNA.Quiz today!
AgendaWhiteboards reviewTranscription & Translation quiz
Normal vs Sickle Cell Poster
Whiteboards!One side of tRNA has an ______ ______ and the other side has a __________ Amino acid, anticodon
Whiteboards!Where does transcription occur and what is the product? Nucleus & mRNA
Where does translation occur and what is the product? Cytoplasm & protein (amino acid chain)
What is the mRNA strand for the following DNA strand?
DNA: T A C G G A C T TmRNA: A U G C C U G A A
What is the function of ribosomes? Build proteins
What are the possible codons for the amino acid ASP? GAU or GAC
We use genes as the templates for making __________. mRNA
What is the amino acid sequence for the following mRNA strand?
mRNA: AUG GGU AAG MET GLY LYS
What are the three differences between DNA & RNA? DNA: deoxyribose, Thymine, double stranded
RNA: ribose, Uracil, single stranded
Transcription Occurs in nucleus Produces mRNA using a gene as a
template mRNA – RiboNucleic Acid
Contains the sugar Ribose Instead of Thymine – T, mRNA uses
Uracil – U mRNA is single stranded
Translation Occurs in the cytoplasmRibosomes read the mRNA stand and coordinate the addition of amino acids in the proper sequence.
Produces proteins
Genetic Information is first expressed as RNA
There are three types of RNA mRNA – messenger RNA carries
information from the nucleus to the cytoplasm where protein is made/translated
tRNA – transfer RNA – transfers amino acids to a protein .
rRNA – ribosomal RNA These RNA strands function in assembling
amino acids to make proteins
Intro to Gene Expression Poster You will be completing a poster that
demonstrates the harmful impacts of mutations.
Things you will need: Poster checklist Poster DNA sequence slip Need to know box on pg. 459 Poster template on pg. 460
Create a poster Create a poster comparing Normal alleles
with Sickle – cell alleles Your poster will need to include
Genotype DNA sequence mRNA sequence Polypeptide structure Shape of hemoglobin molecule Behavior of the hemoglobin molecule Shape of the red blood cell under low oxygen Medical implications
DNA Sequence
mRNA Sequence
Amino Acid Sequence
DNA Sequence
mRNA Sequence
Amino Acid Sequence
Picture of normal blood
Normal blood
Sickle Cell blood
Behavior: How does
normal hemoglobin behave under low oxygen?
Picture of how
normal blood
behaves under low
oxygen
Medical implication
s
Picture of sickle cell
blood
Behavior: How does sickle cell hemoglobin behave under low oxygen?
Picture of how sickle cell blood behaves
under low oxygen
Medical implication
s
Exit SlipWhat effect does a DNA mutation have on the protein the cell makes?
What part (if any) of transcription and translation do you have trouble understanding?
How did you do? Rate yourself!We will determine the effects of mutations on
an amino acid sequenceI will ace the transcription & translation quiz!
Bell Ringer – 04/23
Learning Target: We will determine the effects of mutations on hemoglobin.Closure task: I will complete my sickle cell anemia poster.
Human DNA is made up of 29% Adenine, 21% Guanine, 29% Thymine, and 21% Cytosine.• What does this data tell us about our
DNA composition?
What if a mutation does not change the amino acid sequence. Will this mutation affect protein function?
Bell Ringer – 04/23
Learning Target: We will determine the effects of mutations on hemoglobin.Closure task: I will complete my sickle cell anemia poster.
Open up your textbooks to pg. 460
Write down “posters” for your bell ringer.
AgendaNormal vs Sickle Cell PosterReview for test
Intro to Gene Expression Poster You will be completing a poster that
demonstrates the harmful impacts of mutations.
Things you will need: Poster checklist Poster DNA sequence slip Need to know box on pg. 459 Poster template on pg. 460
Create a poster Create a poster comparing Normal alleles
with Sickle – cell alleles Your poster will need to include
Genotype DNA sequence mRNA sequence Polypeptide structure Shape of hemoglobin molecule Behavior of the hemoglobin molecule Shape of the red blood cell under low oxygen Medical implications
Summary of poster project What was the main purpose of this
activity?
Review
Topics on the unit exam:DNA structureDNA replicationMitosisTranscriptionTranslation
DNA structure Take our your annotated DNA structure
handout DNA is made up of units called __________.
nucleotides
DNA structure __________ hold the two DNA strands
together. The only part that changes from
nucleotide to nucleotide is the __________________.
Hydrogen bonds
Nitrogen Base
DNA Replication Step 1: An enzyme (helicase) _________ the
DNA. Step 2: Another enzyme (DNA polymerase)
binds to each DNA strand and creates ________________________________
What are the complementary base pairs? A – T C - G
Unzips
a new DNA strand on each old DNA strand
DNA Replication
Semi-conservative replication
Cell Cycle During which phase does DNA
replication occur? S phase
What are the four stages of mitosis? Prophase, Metaphase, Anaphase,
Telophase What phase does the cell spend
most of its time? Interphase
Cell Cycle
https://www.youtube.com/watch?v=Wy3N5NCZBHQ
Mitosis
Cell Differentiation
Each cell has the same DNA, but has a different function.
Transcription
http://www.pbslearningmedia.org/resource/lsps07.sci.life.stru.celltrans/cell-transcription-and-translation/
Translation
Exit SlipWhat is complementary base pairing?
What is wrong with cancer cells?
How did you do? Rate yourself!We will determine the effects of mutations on
hemoglobin.I will complete my sickle cell anemia poster.
MOLECULAR GENETICS UNIT TEST
Bell Ringer – 04/24
Learning Target: We will review for the gene expression unit test.Closure task: I will ace the gene expression unit test!
1.What are the three parts of a nucleotide?
2.What are the four stages of the cell cycle?
Unit Test today!
AgendaReview for Unit testUnit test!Human cloning????
Review
Topics on the unit exam:DNA structureDNA replicationMitosisTranscriptionTranslation
DNA structure Take our your annotated DNA structure
handout DNA is made up of units called __________.
nucleotides
DNA structure __________ hold the two DNA strands
together. The only part that changes from
nucleotide to nucleotide is the __________________.
Hydrogen bonds
Nitrogen Base
DNA Replication Step 1: An enzyme (helicase) _________ the
DNA. Step 2: Another enzyme (DNA polymerase)
binds to each DNA strand and creates ________________________________
What are the complementary base pairs? A – T C - G
Unzips
a new DNA strand on each old DNA strand
DNA Replication
Semi-conservative replication
Cell Cycle During which phase does DNA
replication occur? S phase
What are the four stages of mitosis? Prophase, Metaphase, Anaphase,
Telophase What phase does the cell spend
most of its time? Interphase
Cell Cycle
https://www.youtube.com/watch?v=Wy3N5NCZBHQ
Mitosis
CancerWhat is wrong with cancerous cells? Uncontrolled cell division
Cell Differentiation
Each cell has the same DNA, but has a different function.
TranscriptionStep 1: RNA polymerase (enzyme) _________ DNA molecule
Step 2: RNA polymerase reads and builds a __________
mRNA replaces _______ with _______
unzips
mRNA strand
ThymineUracil
Transcription
http://www.pbslearningmedia.org/resource/lsps07.sci.life.stru.celltrans/cell-transcription-and-translation/
After transcription….After transcription, the mRNA travels from the ___________ to the ____________
NucleusCytoplas
m
TranslationStep 1: __________ binds to the mRNA.
Step 2: ______ bring amino acids to the ________
Step 3: The ________ reads the mRNA codons and builds a ______________________
RibosometRNA
ribosome ribosom
echain of amino acids (protein)
Translation
Mutations
Insertion
Silent mutation
Extra Human Cloning
https://www.youtube.com/watch?v=pPz8LEQqARo
Heart from stem cells https://
www.youtube.com/watch?v=j9hEFUpTVPA
Exit SlipWhat activities/videos/worksheets helped you during this unit?
What activities/videos/worksheets did not help you this unit?
What could I have done to make the material clearer?
How did you do? Rate yourself!We will review for the gene expression unit
test.I will ace the gene expression unit test!
GENE EXPRESSION UNIT TEST RECOVERY
Bell Ringer – 04/27
Learning Target: We will recover the gene expression unit test.Closure task: I will take the recovery quiz for at the least one standard.
1. What activities/videos/worksheets helped you during this unit?
2. What activities/videos/worksheets did not help you this unit?
3. What could I have done to make the material clearer?
AgendaRecover the gene expression unit test!
Unit test recovery Use the Self Assessment
handout to determine which standards you have to recover.
Complete the handout(s) for the specific standard(s) you have to recover.
The last 15 minutes of class we will take the recovery quizzes.
I will need all of the tests back at the end of class
Useful pages for recoveryDNA structure & replication: 512
Cell Cycle & Mitosis: 578Protein synthesis: 521
Exit SlipWrite down 5 words that comes to mind when you hear the word “Ecology.”
Write down 3 words that come to mind when you hear the phrase “food webs.”
How did you do? Rate yourself!We will recover the gene expression unit test.
I will take the recovery quiz for at the least one standard.
Extract your own DNA http://
www.pbs.org/wgbh/nova/body/extract-your-dna.html
Journey into human DNA http://www.pbs.org/wgbh/nova/body/jour
ney-into-human-dna.html
Notes Bond types: Covalent and Hydrogen
Gene Expression We are a skin cell and we
need to make the protein collagen.
What is the first step in gene expression?
What is the second step in gene expression?
Think-Pair-Share
Translation
Transcription & Translation
Why is translation important?
Protein structure Proteins are made
up of amino acids. Depending on the
interaction of those amino acids, they form different 3D shapes.
Their function depends on their shape
Exit question The mRNA sequence UGC codes for Cys.
A mutation occurs and the resulting sequence is UGG.
What amino acid would replace Cys?
Bellringer What is the RNA sequence for the amino
acid sequence Pro-Asn-Gly? A) CUU-AAU-GUU B) CUU-CGU-UAG C)CCU-AAU-GGU D)GCU-GUG-CUG
Standard Topic: Translation Learning Target: I can describe
transcription Closure Task: I will complete the
translation quiz
T-P-I instructions. T= teacher. You will be working with me at the
back table P=pairs. You will find another “P” and work
together to fix/finish your work. I=independent. You will work on your own to
complete the next worksheet. All students need to work on #2 describing
translation. You need to tell me the roles of the 3 types of RNA in translation.
You will turn the blue sheets back in at the end of class
You will also be completing a yellow worksheet.
Bellringer
Person A and B have a similar mRNA sequences.
What is the difference in the amino acid sequence?
Learning Target: I can describe translation
Closure Task: I will complete the translation quiz
Person A
AUG CCU ACA AGC GGC CUA
Person B
AUG CCU AGA AGC GGC CUA