TRANSFORMING HEALTHCARE

THE QUANTIFICATION OF

EVERYTHINGSTEVEN TUCKER, MD, FACP, FAMS

Global Health Advisor, SingTel Founder, Tucker Medical

WARNING !

We tend to overestimate the effect of a technology

in the short run and underestimate the effect

in the long run.

Roy AmaraCo-founder, Institute for the Future

1EXPONENTIALS

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

EXPONENTIALS

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

COMPUTING POWER

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

MOORE’S LAW

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

MOORE’S LAW

Computers

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

MOORE’S LAW

ComputersSensors

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

MOORE’S LAW

ComputersSensors

Biology

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

MOORE’S LAW

ComputersSensors

Pan-omicsBiology

2PROBLEMS

Healthcare is not a science problem, it’s an information problem.

-Thomas Goetz

DIABETES

382Million

Source: International Diabetes Federation

OBESITY

500Million

Source: World Health Organisation

HEART DISEASE

17.3Million

Source: World Health Organisation

CANCER

14.1Million

Source: World Health Organisation

3SENSORS

If you cannot measure it, you cannot improve it.

-Lord Kelvin

SENSOR EVOLUTION

Sensor 1.0

Sensor 2.0

Sensor 3.0

Ability to measure + record signal

Sensor web integration; share + access data

Passive data gathering + aggregating + meaningful insight

ACTIVITY

HEALTH

MEDICAL

THE TRICORDER

VITAL SIGNS

EMERGENCY

BIRTH CONTROL

WIRELESS BIRTH CONTROL

4BIOLOGY

THERANOS

RETAIL LABS

HOME TRACKING

HOME DIAGNOSIS

HOME DIAGNOSIS

LAB ON A CHIP

CELL CAPTURE

LIQUID BIOPSY

GENOME MATH

23Pairs ofchromosomes

GENOME MATH

20kGenes

GENOME MATH

4Bases

A - TG - C

GENOME MATH

3.2Base pairsper genome

billion

GENOME MATH

3.2billion BP

40x Coverage

128billiondata points

SEQUENCING $

GENOMICS 2001

GENOMICS 2007

GENOMICS 2013

GENOMICS 2014

GENOMICS 2014

GENOMICS 2016

GENOMICS 2018

NEXT GEN SEQUENCING

NEXT NEXT GEN

SEQUENCING

?

5PLATFORMS

$2.4Billion

$26Billion

SENSORS

SENSORSGyroscope Proximity

SENSORSGyroscope

Gesture

Proximity

Fingerprint

SENSORSGyroscope

Gesture

Proximity

Compass

Fingerprint

Hall cover

SENSORSGyroscope

Gesture

Heart rate

Proximity

Compass

Barometer

Fingerprint

Hall cover

SENSORSGyroscope

Ambient light

Gesture

Heart rate

Accelerometer

Proximity

Compass

Barometer

Fingerprint

Hall cover

6PAN-OMICS

Exposome

Hg80

Cd48

33

Pb82

Ti81

Ni28

As

PhenomeEpigenome

!TRANSFORM

Digital Health as Google Map

SENSOR ACTIVITY

GENOME

MICROBIOME

LAB

PHENOME

UNIQUE PERSON

DIET

HEALTH AS A GOOGLE MAP

Digital Health as Google Map

SENSOR ACTIVITY

GENOME

MICROBIOME

LAB

PHENOME

UNIQUE PERSON

DIET

HEALTH AS A GOOGLE MAP

6P4

MEDICINE

P4 MEDICINE

1. Predictive 2. Preventive 3. Personalized 4. Participatory

1. Predictive 2. Preventive 3. Personalized 4. Participatory

100k WELLNESS PROJECT

P4 MEDICINE

Predictive You will track your health. It’s your data. Identify transition states.

P4 MEDICINE

Preventive Wellness networks. Illness networks. A systems-based approach to repair and maintenance.

P4 MEDICINE

Personalized You are your own control. Your health data cloud. Molecular + Environmental.

P4 MEDICINE

Participatory Transformative for health. Societal change - enormous. Patients will adapt. Doctors may adapt?

Health Status 20% of patients = 80% of costs

VALUE COST

Healthy Low Risk At Risk High

Risk

Chronic Disease

Early

Active Disease

Chronic Disease

Progression

End of Life Care

THE PIVOT

6LONGEVITY

Life  Expectancy  at  birth

70

73

76

79

82

85

Years  of  Educa>on<  12 12 13-­‐15 >  16

1990 2000 2008 1990 2000 2008 1990 2000 2008 1990 2000 2008

TECHNOLOGY

BIOLOGY

CALICO

7AND…

THANK  YOUFor  your  9me  &  a>en9on