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Transition cow nutrition and management to optimize performance of dairy cattle Thomas R. Overton, Ph.D. Professor and Chair Director, PRO-DAIRY Department of Animal Science Cornell University

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Transition cow nutrition and management to optimize performance of dairy cattle

Thomas R Overton PhDProfessor and Chair

Director PRO-DAIRYDepartment of Animal Science

Cornell University

Transition period goalsbull High milk productionbull Maintainminimize loss of BCSbull Low incidence of metabolic disordersbull Minimize loss of immunocompetencebull Controldecrease days to first ovulation and maintainenhance fertilitybull Low stillborn rate and healthy calves

bull Our high performing dairies achieve ALL of these by focusing on continuous improvement in all areas of transition cow management

Shift in mindset from the transition cow as a disease opportunity to the transition cow as a

production and reproduction opportunity

Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism

bull Hypocalcemiandash biology nutrition management assessment

bull Fresh cow nutritional strategiesndash Starch levels fiber levels MP and AA

bull Targeted supplies of nutrientsndash AA choline chromium biotin

bull Protein metabolismndash Regulationnutritional influences

bull Inflammationimmuneacute phase responsestressndash Biology nutrition management assessment

bull Epigenetics of nutrition and managementbull Cow and herd-level assessment strategies

ndash Hyperketonemia hypocalcemia inflammationimmunitystressndash Technology implementation

Top ten things to do for healthy and productive transition cows

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

Subclinical hypocalcemia risksbull Impaired health

ndash Metritis (Martinez et al 2012)ndash DA (Chapinal et al 2011)ndash Mastitis (Curtis et al 1983)ndash Subclinical and clinical ketosis (Curtis et al 1983 Ribeiro et al 2011)ndash Immune function (Kimura et al 2002 Martinez et al 2012)

bull Decreased milk production (Chapinal et al 2012)

bull Poorer reproductive performancendash Reduced pregnancy rate (Martinez et al 2012)ndash Reduced pregnancy to first service (Chapinal et al 2012)ndash Longer interval to pregnancy (Martinez et al 2012)

bull Chronic subclinical hypocalcemia increased disease frequency and increased time to pregnancy (Caixeta et al 2017)

Prepartum dietary management is most effective way of preventing postpartum hypocalcemia

bull Manipulate dietary cation anion difference (DCAD)ndash Minimizeavoid high potassium forages (legumes)ndash Supplement anions (chloride andor sulfur containing supplements)

bull Actualize a low calcium diet through use of a binder of calcium in the diet to decrease absorptionndash Synthetic Zeolite A

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Transition period goalsbull High milk productionbull Maintainminimize loss of BCSbull Low incidence of metabolic disordersbull Minimize loss of immunocompetencebull Controldecrease days to first ovulation and maintainenhance fertilitybull Low stillborn rate and healthy calves

bull Our high performing dairies achieve ALL of these by focusing on continuous improvement in all areas of transition cow management

Shift in mindset from the transition cow as a disease opportunity to the transition cow as a

production and reproduction opportunity

Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism

bull Hypocalcemiandash biology nutrition management assessment

bull Fresh cow nutritional strategiesndash Starch levels fiber levels MP and AA

bull Targeted supplies of nutrientsndash AA choline chromium biotin

bull Protein metabolismndash Regulationnutritional influences

bull Inflammationimmuneacute phase responsestressndash Biology nutrition management assessment

bull Epigenetics of nutrition and managementbull Cow and herd-level assessment strategies

ndash Hyperketonemia hypocalcemia inflammationimmunitystressndash Technology implementation

Top ten things to do for healthy and productive transition cows

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

Subclinical hypocalcemia risksbull Impaired health

ndash Metritis (Martinez et al 2012)ndash DA (Chapinal et al 2011)ndash Mastitis (Curtis et al 1983)ndash Subclinical and clinical ketosis (Curtis et al 1983 Ribeiro et al 2011)ndash Immune function (Kimura et al 2002 Martinez et al 2012)

bull Decreased milk production (Chapinal et al 2012)

bull Poorer reproductive performancendash Reduced pregnancy rate (Martinez et al 2012)ndash Reduced pregnancy to first service (Chapinal et al 2012)ndash Longer interval to pregnancy (Martinez et al 2012)

bull Chronic subclinical hypocalcemia increased disease frequency and increased time to pregnancy (Caixeta et al 2017)

Prepartum dietary management is most effective way of preventing postpartum hypocalcemia

bull Manipulate dietary cation anion difference (DCAD)ndash Minimizeavoid high potassium forages (legumes)ndash Supplement anions (chloride andor sulfur containing supplements)

bull Actualize a low calcium diet through use of a binder of calcium in the diet to decrease absorptionndash Synthetic Zeolite A

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Shift in mindset from the transition cow as a disease opportunity to the transition cow as a

production and reproduction opportunity

Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism

bull Hypocalcemiandash biology nutrition management assessment

bull Fresh cow nutritional strategiesndash Starch levels fiber levels MP and AA

bull Targeted supplies of nutrientsndash AA choline chromium biotin

bull Protein metabolismndash Regulationnutritional influences

bull Inflammationimmuneacute phase responsestressndash Biology nutrition management assessment

bull Epigenetics of nutrition and managementbull Cow and herd-level assessment strategies

ndash Hyperketonemia hypocalcemia inflammationimmunitystressndash Technology implementation

Top ten things to do for healthy and productive transition cows

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

Subclinical hypocalcemia risksbull Impaired health

ndash Metritis (Martinez et al 2012)ndash DA (Chapinal et al 2011)ndash Mastitis (Curtis et al 1983)ndash Subclinical and clinical ketosis (Curtis et al 1983 Ribeiro et al 2011)ndash Immune function (Kimura et al 2002 Martinez et al 2012)

bull Decreased milk production (Chapinal et al 2012)

bull Poorer reproductive performancendash Reduced pregnancy rate (Martinez et al 2012)ndash Reduced pregnancy to first service (Chapinal et al 2012)ndash Longer interval to pregnancy (Martinez et al 2012)

bull Chronic subclinical hypocalcemia increased disease frequency and increased time to pregnancy (Caixeta et al 2017)

Prepartum dietary management is most effective way of preventing postpartum hypocalcemia

bull Manipulate dietary cation anion difference (DCAD)ndash Minimizeavoid high potassium forages (legumes)ndash Supplement anions (chloride andor sulfur containing supplements)

bull Actualize a low calcium diet through use of a binder of calcium in the diet to decrease absorptionndash Synthetic Zeolite A

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism

bull Hypocalcemiandash biology nutrition management assessment

bull Fresh cow nutritional strategiesndash Starch levels fiber levels MP and AA

bull Targeted supplies of nutrientsndash AA choline chromium biotin

bull Protein metabolismndash Regulationnutritional influences

bull Inflammationimmuneacute phase responsestressndash Biology nutrition management assessment

bull Epigenetics of nutrition and managementbull Cow and herd-level assessment strategies

ndash Hyperketonemia hypocalcemia inflammationimmunitystressndash Technology implementation

Top ten things to do for healthy and productive transition cows

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

Subclinical hypocalcemia risksbull Impaired health

ndash Metritis (Martinez et al 2012)ndash DA (Chapinal et al 2011)ndash Mastitis (Curtis et al 1983)ndash Subclinical and clinical ketosis (Curtis et al 1983 Ribeiro et al 2011)ndash Immune function (Kimura et al 2002 Martinez et al 2012)

bull Decreased milk production (Chapinal et al 2012)

bull Poorer reproductive performancendash Reduced pregnancy rate (Martinez et al 2012)ndash Reduced pregnancy to first service (Chapinal et al 2012)ndash Longer interval to pregnancy (Martinez et al 2012)

bull Chronic subclinical hypocalcemia increased disease frequency and increased time to pregnancy (Caixeta et al 2017)

Prepartum dietary management is most effective way of preventing postpartum hypocalcemia

bull Manipulate dietary cation anion difference (DCAD)ndash Minimizeavoid high potassium forages (legumes)ndash Supplement anions (chloride andor sulfur containing supplements)

bull Actualize a low calcium diet through use of a binder of calcium in the diet to decrease absorptionndash Synthetic Zeolite A

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Top ten things to do for healthy and productive transition cows

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

Subclinical hypocalcemia risksbull Impaired health

ndash Metritis (Martinez et al 2012)ndash DA (Chapinal et al 2011)ndash Mastitis (Curtis et al 1983)ndash Subclinical and clinical ketosis (Curtis et al 1983 Ribeiro et al 2011)ndash Immune function (Kimura et al 2002 Martinez et al 2012)

bull Decreased milk production (Chapinal et al 2012)

bull Poorer reproductive performancendash Reduced pregnancy rate (Martinez et al 2012)ndash Reduced pregnancy to first service (Chapinal et al 2012)ndash Longer interval to pregnancy (Martinez et al 2012)

bull Chronic subclinical hypocalcemia increased disease frequency and increased time to pregnancy (Caixeta et al 2017)

Prepartum dietary management is most effective way of preventing postpartum hypocalcemia

bull Manipulate dietary cation anion difference (DCAD)ndash Minimizeavoid high potassium forages (legumes)ndash Supplement anions (chloride andor sulfur containing supplements)

bull Actualize a low calcium diet through use of a binder of calcium in the diet to decrease absorptionndash Synthetic Zeolite A

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

Subclinical hypocalcemia risksbull Impaired health

ndash Metritis (Martinez et al 2012)ndash DA (Chapinal et al 2011)ndash Mastitis (Curtis et al 1983)ndash Subclinical and clinical ketosis (Curtis et al 1983 Ribeiro et al 2011)ndash Immune function (Kimura et al 2002 Martinez et al 2012)

bull Decreased milk production (Chapinal et al 2012)

bull Poorer reproductive performancendash Reduced pregnancy rate (Martinez et al 2012)ndash Reduced pregnancy to first service (Chapinal et al 2012)ndash Longer interval to pregnancy (Martinez et al 2012)

bull Chronic subclinical hypocalcemia increased disease frequency and increased time to pregnancy (Caixeta et al 2017)

Prepartum dietary management is most effective way of preventing postpartum hypocalcemia

bull Manipulate dietary cation anion difference (DCAD)ndash Minimizeavoid high potassium forages (legumes)ndash Supplement anions (chloride andor sulfur containing supplements)

bull Actualize a low calcium diet through use of a binder of calcium in the diet to decrease absorptionndash Synthetic Zeolite A

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Subclinical hypocalcemia risksbull Impaired health

ndash Metritis (Martinez et al 2012)ndash DA (Chapinal et al 2011)ndash Mastitis (Curtis et al 1983)ndash Subclinical and clinical ketosis (Curtis et al 1983 Ribeiro et al 2011)ndash Immune function (Kimura et al 2002 Martinez et al 2012)

bull Decreased milk production (Chapinal et al 2012)

bull Poorer reproductive performancendash Reduced pregnancy rate (Martinez et al 2012)ndash Reduced pregnancy to first service (Chapinal et al 2012)ndash Longer interval to pregnancy (Martinez et al 2012)

bull Chronic subclinical hypocalcemia increased disease frequency and increased time to pregnancy (Caixeta et al 2017)

Prepartum dietary management is most effective way of preventing postpartum hypocalcemia

bull Manipulate dietary cation anion difference (DCAD)ndash Minimizeavoid high potassium forages (legumes)ndash Supplement anions (chloride andor sulfur containing supplements)

bull Actualize a low calcium diet through use of a binder of calcium in the diet to decrease absorptionndash Synthetic Zeolite A

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Prepartum dietary management is most effective way of preventing postpartum hypocalcemia

bull Manipulate dietary cation anion difference (DCAD)ndash Minimizeavoid high potassium forages (legumes)ndash Supplement anions (chloride andor sulfur containing supplements)

bull Actualize a low calcium diet through use of a binder of calcium in the diet to decrease absorptionndash Synthetic Zeolite A

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Major strategies for application of DCAD for close-up dry cows

bull Focus on feeding low K (and Na) forages and feeds to close-up dry cowsbull Calculated DCAD ~ +10 mEq100 g of DMbull Urine pH ~ 83 to 85

bull Feeding low K forages along with partial use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ 0 mEq100 g of DMbull Urine pH ~ 75

bull Feeding low K forages along with full use of anionic supplement in close-up ration or one-group dry cow ration

bull Calculated DCAD ~ -10 to -15 mEq100 g of DMbull Urine pH ~ 55 to 60 ndash need to monitor weekly and adjust DCAD supplementation if out of range

bull Need to also supplement Mg (dietary target ~ 045) during close-upbull Recommend supplementing Ca (09 to 10 if low K only 14 to 15 if full

anionic diet)

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Summary considerations for effective DCAD diet implementation

bull Account for macrominerals in forages (wet chemistry)bull CONSISTENCY in foragesfeedsmixing is keybull Prevent sorting of ration

bull Particle size of TMR and moisturebull Sources

bull Commercial products best (palatability)bull Some sources poor palatability (Ca chloride ammonium chloride)

bull Make sure you supplement Mg (Mg oxide Mg sulfate commercial Mg sources)

bull Use urine pH monitoring to gauge implementationbull Urine pH 6 to 7 has been general recommendationbull With excellent management can target urine pH 55 to 6bull Target CV lt 8 (12 to 15 cows 4 to 6 h postfeeding if possible)

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Grabher et al 2009 Thilsing-Hansen et al 2001

Feeding synthetic Zeolite A prepartum improves blood Ca status at calving

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Synthetic Zeolite A fed during the prepartum period

bull Objective To determine the effect of feeding sodium aluminum silicate to multiparous Holstein cows during the prepartum period on serum mineral status dry matter intake postpartum performance and oxidative status

bull Enrolled 60 multiparous Holstein cowsbull 5 cows removed 3 calved with twinscalved early 1 had a DA prepartum 1 diagnosed

with toxic mastitisbull 2nd lactation n=24 ge3rd lactation n=31

bull Cows enrolled 28 d prior to expected calving and randomly assigned to one of two dietary treatments starting 21 d prior to expected calving

bull Control (CON n=29) - Contains 40 CS 33 wheat straw and 27 concentratebull Experiment (EXP n=26) - CON diet with the addition of sodium aluminum silicate (X-Zelit

Protekta Inc Lucknow Ontario CAVitfoss Graasten DK) at 33 of DM targeting 500 gd as fed

bull Cows fed same postpartum ration Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Calcium

6065707580859095

100105110

-17 -10 -5 -3 -1 0 025075 2 3 4 6 7 10 15

Ca (

mg

dL)

Day Relative to Calving

CON

EXP

Prepartum effectsTrt P lt 00001Day P = 00002Trt x day P = Postpartum effects

Trt P lt 00001Day P lt 00001Trt x day P = 00006

Kerwin et al 2019 J Dairy Sci 1025191ndash5207

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calving

ndash Emphasis on ldquobypassrdquo protein sources and balancing AA

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Summary guidelines -- dry period nutritional strategies

bull Far-offndash Keep energy down (059 to 063 Mcallb 130 to 139 Mcalkg of NEL 110 to 120 of

energy requirements lt 13 starchndash Macromineral balances not important (within reason)

bull Close-up (if same ration fed to heifers and older cows)ndash Low to moderate energy (064 to 066 Mcallb 140 to 145 Mcalkg of NEL 110 to

130 of energy requirements 16 to 18 starchndash Supplement with RUP (MP for Holsteins 1200 to 1400 gd)ndash Macromineral relationships (K Mg Na S Cl maybe Ca) critically important Vitamins

D and E trace elements

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

General recommendations ndash one-group nutritional strategies

bull Low to moderate energy (135 to 140 Mcalkg -- ~ 063 Mcallb of NEL 110 to 130 of energy requirements 14 to 16 starch)

bull Supplement with RUP (MP for Holsteins ~ 1200 gd)

bull Formulate minerals like close-up ration

bull Always a bit of a compromise (performance health cost) compared to two-group systems but most practical option on some farms

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every day

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Keys to feeding management of dry cow TMR

bull Minimize sortingndash Particle size of strawhay

bull Longest particles lt 15 in (4 cm)ndash Moisture content of TMR

bull Target 46 to 48 DM -- add water if necessary

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Screen Lactating cow TMR

Dry cow TMR

Corn silage Hay crop silage

Strawdryhay for TMR

Top (gt 075rdquo sieve)

6 to 10 10 to 20 5 to 10 10 to 20 33

Middle(031 to 075 in sieve)

45 to 55 50 to 60 45 to 65 45 to 75 33

Bottom(lt 031 in sieve)

lt 50 lt 40 30 to 40 20 to 30 33

Particle size recommendations using Penn State Particle Separator

Adapted from Penn State guidelines by T Overton 92013

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle

Separator (n=72 farms Lawton et al 2015)

0

10

20

30

40

50

60

70

o

f net

wei

ght

Recommendation72 farms

Top Middle Bottom

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Deviations from total target weight and ingredient deviations for 25 CA dairies

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Rodriguez et al (Silva-del-Rio) 2015 DCRC

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchy

ndash Stocking density commingling cowsheifers group changes

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stress

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)

Tao and Dahl 2013 J Dairy Sci 96 4079ndash4093

+ 26

+ 79

+ 57

+ 42

+ 165 + 50

+ 110

+ 114

+ 139

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Heat stress in utero has the following effects on the calf (Dahl)

bull Decreased birth weight

bull Greater incidence of Failure of Passive Transfer

bull Poorer immune function

bull Poorer feed efficiency

bull Decreased milk production (~ 11 lbsd) during first lactation

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cows

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

BMR corn silage during the transition period

3 wk Prefresh

Conventionalcorn silagehybrids

BMRcorn silage

gt 3 wks post-fresh

Conventionalcorn silagehybrids

BMRcorn silage

Wks 35 ndash 15

Conv CS

Diet formulation goal Keep all parameters the same withthe exception of NDF digestibility Diets formulated with CPM Dairy

Stone et al 2012 J Dairy Sci 95 6665ndash6676

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

Days before or after calving

DMI of cows fed BMR or conventional corn silage during the transition period (Stone et al 2012)

0

5

10

15

20

25

30

-25 -15 -5 5 15 25 35 45 55 65 75 85 95 105

Kgd

ay BMRControl

DMI d -14 to -1 143 vs 132 P lt 003DMI d 0 ndash 21 202 vs 182 P lt 0001

Stone et al 2012 J Dairy Sci 95 6665ndash6676

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

DMI entire study

BMR
Control
Kgday
143163
157218
146244
15022
14761
146022
153112
146643
148316
145964
148948
15161
151551
149311
148666
149182
148058
139129
152718
141103
152758
142393
152327
13935
154088
138809
151348
140273
148388
131923
146506
132639
144682
128371
141115
128341
14187
123821
134912
125138
84946
88237
152535
143032
169173
143937
173176
148294
180861
157376
189161
167571
194364
175491
192894
181379
194836
179209
192542
180588
195176
184532
20567
184132
212655
186491
210136
189653
213118
196447
209036
193429
208948
190218
21922
191126
220506
192829
226621
202874
229097
20605
224494
204082
228903
208774
23053
21004
230536
213056
234421
218296
228233
223305
229748
225741
237358
218318
236639
226653
232691
220247
237742
225497
238133
226268
24567
231762
240203
235491
242536
234256
240052
238762
236676
233397
237388
227965
248273
237938
246361
245133
245227
250157
248073
249036
243767
251557
244958
255727
24213
25485
248121
251693
248694
255812
256636
262434
255376
266304
259955
25885
252039
248134
251627
253134
255624
246412
256206
251737
256709
254682
252912
256583
256133
255271
253594
25677
252833
255097
257939
25121
2577
258426
2555
256292
262682
257048
261291
250629
264532
251975
26047
2485
269452
255343
268924
251862
271379
256547
266461
262987
271042
265142
269282
265181
265991
259778
267644
264166
265864
264188
27377
266076
271614
259733
263021
25197
269615
257048
266121
2554
264051
257327
265285
258261
257703
259582
264186
263727
258021
264873
259816
258736
260421
255861
262101
263291
264657
262179
270612
262603
257998
26367
256659
262836
265933
252582
258057
25877
260461
257017
261576
260222
263291
258723
264342
254226
254589
260918
253588
258266
249975
256084
24912
255244
243671
25545
246014
260668
251936
256535
254763
251679

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446
-21 -21 08309 08269
-20 -20 07913 08019
-19 -19 07546 07737
-18 -18 07438 07382
-17 -17 07247 07149
-16 -16 07133 06959
-15 -15 07034 06824
-14 -14 06859 06763
-13 -13 06738 06737
-12 -12 06694 06692
-11 -11 06694 06718
-10 -10 06694 06688
-9 -9 06694 06683
-8 -8 06694 06675
-7 -7 06694 06661
-6 -6 06694 06637
-5 -5 06694 06595
-4 -4 06694 06595
-3 -3 06694 06595
-2 -2 06694 06595
-1 -1 06722 06622
0 0 06752 06595
1 1 06694 06622
2 2 06694 06595
3 3 06694 06595
4 4 06694 06595
5 5 06694 06595
6 6 06694 06595
7 7 06694 06595
8 8 06694 06595
9 9 06694 06595
10 10 06694 06595
11 11 06694 06595
12 12 06694 06595
13 13 06694 06595
14 14 06694 06595
15 15 06694 06595
16 16 06722 06595
17 17 06694 06595
18 18 06694 06595
19 19 06694 06595
20 20 06694 06595
21 21 06694 06595
22 22 06694 06622
23 23 06694 06595
24 24 06694 06622
25 25 06694 06622
26 26 06694 06595
27 27 06694 06595
28 28 06694 06595
29 29 06694 06595
30 30 06694 06595
31 31 06694 06595
32 32 06694 06595
33 33 06694 06595
34 34 06694 06595
35 35 06694 06595
36 36 06694 06595
37 37 06694 06595
38 38 06694 06637
39 39 06694 06661
40 40 06694 06675
41 41 06694 06683
42 42 06694 06688
43 43 06694 0669
44 44 06694 06692
45 45 06694 06693
46 46 06694 06693
47 47 06694 06694
48 48 06694 06694
49 49 06694 06694
50 50 06694 06694
51 51 06694 06694
52 52 06694 06694
53 53 06694 06694
54 54 06694 06694
55 55 06694 06694
56 56 06694 06694
57 57 06694 06694
58 58 06694 06694
59 59 06694 06694
60 60 06694 06694
61 61 06694 06694
62 62 06694 06694
63 63 06694 06694
64 64 06722 06694
65 65 06694 06694
66 66 06694 06694
67 67 06694 06694
68 68 06694 06694
69 69 06694 06694
70 70 06694 06694
71 71 06694 06694
72 72 06694 06694
73 73 06738 06694
74 74 06763 06694
75 75 06778 06694
76 76 06786 06694
77 77 06791 06694
78 78 06794 06694
79 79 06796 06694
80 80 06797 06694
81 81 06797 06694
82 82 06798 06694
83 83 06798 06694
84 84 06798 06694
85 85 06798 06694
86 86 06798 06694
87 87 06798 06694
88 88 06798 06694
89 89 06798 06694
90 90 06844 06694
91 91 0687 06694
92 92 06886 06694
93 93 06895 06738
94 94 069 06763
95 95 06903 06778
96 96 06904 06786
97 97 06905 06821
98 98 06906 06794
99 99 06906 06796
100 100 06906 06797
101 101 06907 06797
102 102 06907 06798
103 103 06907 06827
104 104 06907 06798
105 105 07181 07058

35FCM

BMR
Control
Week of Lactation
Kgd
35 FCM in Cows Fed BMR or Control CS
338037
302599
463173
414237
485687
441193
487775
457508
497718
457896
493987
465047
486269
466614
490699
464426
49266
484362
510671
4754
500479
475503
505164
486472
488797
461745
49945
469977
480308
448894

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251
1 1 21004 20576
2 2 16583 16247
3 3 16822 16577
4 4 15258 15036
5 5 17344 17091
6 6 14438 1431
7 7 13101 12989
8 8 12116 12087
9 9 1462 14592
10 10 11476 11381
11 11 12272 12091
12 12 10746 10655
13 13 09851 09769
14 14 1119 1125
15 15 12467 12446

ECM (Krause)

BMR
Control
Week of Lactation
Milk kgd
ECM for Cows Fed BMR or Conventional Corn Silage During the Transition
321385
284244
422675
4015
434278
396329
435184
405482
442163
406132
441908
412402
434672
419207
437257
413069
438383
428286
455761
425146
448832
424789
454176
433558
439472
416057
44918
423273
429878
402838

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
1 1 17515 17154
2 2 27967 27389
3 3 14839 14622
4 4 1319 12998
5 5 14925 14707
6 6 12503 12393
7 7 11423 11327
8 8 10102 10081
9 9 11627 11608
10 10 09562 09484
11 11 10158 10007
12 12 09171 09096
13 13 0867 086
14 14 09787 09845
15 15 11266 11251

ECM(Krause) over DMI

BMR
Control
Week of Lactation
ECMDMI kgd
Feed Efficiency (ECMDMI) of Cows Fed BMR or Conventional Corn Silage During the Transition Period
18407
18351
2094
21998
19953
20251
18992
2144
18665
17881
18377
17641
17535
16738
17229
16509
16856
17065
17119
16927
16744
16378
17045
17048
16787
16201
17144
16525
1715
16017

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525
1 1
2 2
3 3
4 4
5 5
6 6
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15

LS

BMR
Control
Week of Lactation
Linear score
36311
43088
24079
34088
2197
27265
19545
25088
18636
27147
19394
25415
19545
24457
18667
2386
1862
22783
16119
20759
17554
21972
19263
20889
20389
21636
24102
23985
21555
22394

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043
1 1 03436 03511
2 2 03296 0336
3 3 0292 02963
4 4 03054 031
5 5 03833 03891
6 6 03613 03652
7 7 04361 04398
8 8 03477 03469
9 9 02887 02864
10 10 02693 02678
11 11 02906 02907
12 12 02852 02849
13 13 02986 02982
14 14 03666 03613
15 15 03568 03525

MUN

BMR
Control
Week of Lactation
MUN mgdl
MUN Levels in Cows Fed BMR or Conventional Corn Silage During the Transition Period
100091
106971
103504
118206
107061
116618
107697
116235
111909
99206
115818
105217
112364
114636
12197
115211
114463
120648
117976
117886
118609
114241
11827
113556
118386
120653
12225
126159
121193
119674

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001
1 1 05855 05695
2 2 04588 04471
3 3 03587 03534
4 4 03827 0377
5 5 04262 04198
6 6 04378 04358
7 7 04213 04203
8 8 05044 05107
9 9 04455 04523
10 10 04087 04099
11 11 04981 04928
12 12 03721 03715
13 13 0308 03079
14 14 03271 03361
15 15 04964 05043

Data for Graphs

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43
The S AS System 2208 Wednesday January 2 2008 27
The Mixe d Procedure
DMI Entire Study Standard
Effect trt day Estimate Error
trt B 227066 01601
trt C 220224 01585
Day BMR Control
trtday B -21 143163 08309 C -21 157218 08269
trtday B -20 146244 07913 C -20 15022 08019
trtday B -19 14761 07546 C -19 146022 07737
trtday B -18 153112 07438 C -18 146643 07382
trtday B -17 148316 07247 C -17 145964 07149
trtday B -16 148948 07133 C -16 15161 06959
trtday B -15 151551 07034 C -15 149311 06824
trtday B -14 148666 06859 C -14 149182 06763
trtday B -13 148058 06738 C -13 139129 06737
trtday B -12 152718 06694 C -12 141103 06692
trtday B -11 152758 06694 C -11 142393 06718
trtday B -10 152327 06694 C -10 13935 06688
trtday B -9 154088 06694 C -9 138809 06683
trtday B -8 151348 06694 C -8 140273 06675
trtday B -7 148388 06694 C -7 131923 06661
trtday B -6 146506 06694 C -6 132639 06637
trtday B -5 144682 06694 C -5 128371 06595
trtday B -4 141115 06694 C -4 128341 06595
trtday B -3 14187 06694 C -3 123821 06595
trtday B -2 134912 06694 C -2 125138 06595
trtday B -1 84946 06722 C -1 88237 06622
trtday B 0 152535 06752 C 0 143032 06595
trtday B 1 169173 06694 C 1 143937 06622
trtday B 2 173176 06694 C 2 148294 06595
trtday B 3 180861 06694 C 3 157376 06595
trtday B 4 189161 06694 C 4 167571 06595
trtday B 5 194364 06694 C 5 175491 06595
trtday B 6 192894 06694 C 6 181379 06595
trtday B 7 194836 06694 C 7 179209 06595
trtday B 8 192542 06694 C 8 180588 06595
trtday B 9 195176 06694 C 9 184532 06595
trtday B 10 20567 06694 C 10 184132 06595
trtday B 11 212655 06694 C 11 186491 06595
trtday B 12 210136 06694 C 12 189653 06595
trtday B 13 213118 06694 C 13 196447 06595
trtday B 14 209036 06694 C 14 193429 06595
trtday B 15 208948 06694 C 15 190218 06595
trtday B 16 21922 06722 C 16 191126 06595
trtday B 17 220506 06694 C 17 192829 06595
trtday B 18 226621 06694 C 18 202874 06595
trtday B 19 229097 06694 C 19 20605 06595
trtday B 20 224494 06694 C 20 204082 06595
trtday B 21 228903 06694 C 21 208774 06595
trtday B 22 23053 06694 C 22 21004 06622
trtday B 23 230536 06694 C 23 213056 06595
trtday B 24 234421 06694 C 24 218296 06622
trtday B 25 228233 06694 C 25 223305 06622
trtday B 26 229748 06694 C 26 225741 06595
trtday B 27 237358 06694 C 27 218318 06595
trtday B 28 236639 06694 C 28 226653 06595
trtday B 29 232691 06694 C 29 220247 06595
trtday B 30 237742 06694 C 30 225497 06595
trtday B 31 238133 06694 C 31 226268 06595
trtday B 32 24567 06694 C 32 231762 06595
trtday B 33 240203 06694 C 33 235491 06595
trtday B 34 242536 06694 C 34 234256 06595
trtday B 35 240052 06694 C 35 238762 06595
trtday B 36 236676 06694 C 36 233397 06595
trtday B 37 237388 06694 C 37 227965 06595
trtday B 38 248273 06694 C 38 237938 06637
trtday B 39 246361 06694 C 39 245133 06661
trtday B 40 245227 06694 C 40 250157 06675
trtday B 41 248073 06694 C 41 249036 06683
trtday B 42 243767 06694 C 42 251557 06688
trtday B 43 244958 06694 C 43 255727 0669
trtday B 44 24213 06694 C 44 25485 06692
trtday B 45 248121 06694 C 45 251693 06693
trtday B 46 248694 06694 C 46 255812 06693
trtday B 47 256636 06694 C 47 262434 06694
trtday B 48 255376 06694 C 48 266304 06694
trtday B 49 259955 06694 C 49 25885 06694
trtday B 50 252039 06694 C 50 248134 06694
trtday B 51 251627 06694 C 51 253134 06694
trtday B 52 255624 06694 C 52 246412 06694
trtday B 53 256206 06694 C 53 251737 06694
trtday B 54 256709 06694 C 54 254682 06694
trtday B 55 252912 06694 C 55 256583 06694
trtday B 56 256133 06694 C 56 255271 06694
trtday B 57 253594 06694 C 57 25677 06694
trtday B 58 252833 06694 C 58 255097 06694
trtday B 59 257939 06694 C 59 25121 06694
trtday B 60 2577 06694 C 60 258426 06694
trtday B 61 2555 06694 C 61 256292 06694
trtday B 62 262682 06694 C 62 257048 06694
trtday B 63 261291 06694 C 63 250629 06694
trtday B 64 264532 06722 C 64 251975 06694
trtday B 65 26047 06694 C 65 2485 06694
trtday B 66 269452 06694 C 66 255343 06694
trtday B 67 268924 06694 C 67 251862 06694
trtday B 68 271379 06694 C 68 256547 06694
trtday B 69 266461 06694 C 69 262987 06694
trtday B 70 271042 06694 C 70 265142 06694
trtday B 71 269282 06694 C 71 265181 06694
trtday B 72 265991 06694 C 72 259778 06694
trtday B 73 267644 06738 C 73 264166 06694
trtday B 74 265864 06763 C 74 264188 06694
trtday B 75 27377 06778 C 75 266076 06694
trtday B 76 271614 06786 C 76 259733 06694
trtday B 77 263021 06791 C 77 25197 06694
trtday B 78 269615 06794 C 78 257048 06694
trtday B 79 266121 06796 C 79 2554 06694
trtday B 80 264051 06797 C 80 257327 06694
trtday B 81 265285 06797 C 81 258261 06694
trtday B 82 257703 06798 C 82 259582 06694
trtday B 83 264186 06798 C 83 263727 06694
trtday B 84 258021 06798 C 84 264873 06694
trtday B 85 259816 06798 C 85 258736 06694
trtday B 86 260421 06798 C 86 255861 06694
trtday B 87 262101 06798 C 87 263291 06694
trtday B 88 264657 06798 C 88 262179 06694
trtday B 89 270612 06798 C 89 262603 06694
trtday B 90 257998 06844 C 90 26367 06694
trtday B 91 256659 0687 C 91 262836 06694
trtday B 92 265933 06886 C 92 252582 06694
trtday B 93 258057 06895 C 93 25877 06738
trtday B 94 260461 069 C 94 257017 06763
trtday B 95 261576 06903 C 95 260222 06778
trtday B 96 263291 06904 C 96 258723 06786
trtday B 97 264342 06905 C 97 254226 06821
trtday B 98 254589 06906 C 98 260918 06794
trtday B 99 253588 06906 C 99 258266 06796
trtday B 100 249975 06906 C 100 256084 06797
trtday B 101 24912 06907 C 101 255244 06797
trtday B 102 243671 06907 C 102 25545 06798
trtday B 103 246014 06907 C 103 260668 06827
trtday B 104 251936 06907 C 104 256535 06798
trtday B 105 254763 07181 C 105 251679 07058
trtday
trtday
trtday
Data S et WORKMIL K
Depend ent Vari able fcm
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 481392 11444 607 4207 lt0001
trt C 451458 11286 609 40 lt0001
Week BMR Control
trtweek B 1 338037 21004 616 1609 lt0001 trtweek C 1 302599 20576 61 1471 lt0001
trtweek B 2 463173 16583 667 2793 lt0001 trtweek C 2 414237 16247 66 255 lt0001
trtweek B 3 485687 16822 657 2887 lt0001 trtweek C 3 441193 16577 658 2661 lt0001
trtweek B 4 487775 15258 681 3197 lt0001 trtweek C 4 457508 15036 681 3043 lt0001
trtweek B 5 497718 17344 659 287 lt0001 trtweek C 5 457896 17091 659 2679 lt0001
trtweek B 6 493987 14438 648 3421 lt0001 trtweek C 6 465047 1431 656 325 lt0001
trtweek B 7 486269 13101 65 3712 lt0001 trtweek C 7 466614 12989 657 3592 lt0001
trtweek B 8 490699 12116 634 405 lt0001 trtweek C 8 464426 12087 648 3842 lt0001
trtweek B 9 49266 1462 61 337 lt0001 trtweek C 9 484362 14592 623 3319 lt0001
trtweek B 10 510671 11476 64 445 lt0001 trtweek C 10 4754 11381 647 4177 lt0001
trtweek B 11 500479 12272 623 4078 lt0001 trtweek C 11 475503 12091 623 3933 lt0001
trtweek B 12 505164 10746 62 4701 lt0001 trtweek C 12 486472 10655 627 4566 lt0001
trtweek B 13 488797 09851 639 4962 lt0001 trtweek C 13 461745 09769 645 4726 lt0001
trtweek B 14 49945 1119 608 4463 lt0001 trtweek C 14 469977 1125 629 4177 lt0001
trtweek B 15 480308 12467 607 3853 lt0001 trtweek C 15 448894 12446 62 3607 lt0001
Data S et WORKMIL K
Depend ent Vari able ecm_krau se
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 432347 10468 618 413 lt0001
trt C 406154 1032 619 3935 lt0001
Week BMR Control
trtweek B 1 321385 17515 617 1835 lt0001 C 1 284244 17154 611 1657 lt0001
trtweek B 2 422675 27967 619 1511 lt0001 C 2 4015 27389 613 1466 lt0001
trtweek B 3 434278 14839 67 2927 lt0001 C 3 396329 14622 67 2711 lt0001
trtweek B 4 435184 1319 684 3299 lt0001 C 4 405482 12998 685 312 lt0001
trtweek B 5 442163 14925 665 2963 lt0001 C 5 406132 14707 665 2762 lt0001
trtweek B 6 441908 12503 655 3534 lt0001 C 6 412402 12393 662 3328 lt0001
trtweek B 7 434672 11423 653 3805 lt0001 C 7 419207 11327 661 3701 lt0001
trtweek B 8 437257 10102 637 4328 lt0001 C 8 413069 10081 651 4097 lt0001
trtweek B 9 438383 11627 617 377 lt0001 C 9 428286 11608 631 3689 lt0001
trtweek B 10 455761 09562 648 4767 lt0001 C 10 425146 09484 655 4483 lt0001
trtweek B 11 448832 10158 639 4419 lt0001 C 11 424789 10007 639 4245 lt0001
trtweek B 12 454176 09171 639 4952 lt0001 C 12 433558 09096 646 4767 lt0001
trtweek B 13 439472 0867 64 5069 lt0001 C 13 416057 086 647 4838 lt0001
trtweek B 14 44918 09787 611 459 lt0001 C 14 423273 09845 631 4299 lt0001
trtweek B 15 429878 11266 624 3816 lt0001 C 15 402838 11251 638 3581 lt0001
Data S et WORKMIL K
Depend ent Vari able ecmkras_ dmi
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 1793 004523 661 3964 lt0001
trt C 17798 004457 662 3993 lt0001
Week BMR Control
trtweek B 1 18407 01187 62 1551 lt0001 C 1 18351 01158 616 1585 lt0001
trtweek B 2 2094 01509 624 1388 lt0001 C 2 21998 01472 62 1494 lt0001
trtweek B 3 19953 006209 692 3213 lt0001 C 3 20251 006118 692 331 lt0001
trtweek B 4 18992 02113 578 899 lt0001 C 4 2144 02082 578 103 lt0001
trtweek B 5 18665 005013 739 3723 lt0001 C 5 17881 00494 74 362 lt0001
trtweek B 6 18377 004336 718 4239 lt0001 C 6 17641 004355 73 4051 lt0001
trtweek B 7 17535 004198 736 4177 lt0001 C 7 16738 004177 742 4007 lt0001
trtweek B 8 17229 00367 711 4694 lt0001 C 8 16509 003688 723 4476 lt0001
trtweek B 9 16856 004492 674 3752 lt0001 C 9 17065 004517 684 3778 lt0001
trtweek B 10 17119 003447 678 4967 lt0001 C 10 16927 003431 683 4933 lt0001
trtweek B 11 16744 003491 662 4796 lt0001 C 11 16378 003439 661 4762 lt0001
trtweek B 12 17045 003359 65 5074 lt0001 C 12 17048 003344 654 5098 lt0001
trtweek B 13 16787 003027 711 5546 lt0001 C 13 16201 003013 716 5378 lt0001
trtweek B 14 17144 003075 635 5576 lt0001 C 14 16525 003127 648 5285 lt0001
trtweek B 15 1715 004261 652 4025 lt0001 C 15 16017 004286 661 3737 lt0001
Data S et WORKMIL K
Depend ent Vari able ls
Standard
Effect trt week Estimate Error DF t Value Pr gt |t|
trt B 2105 01999 96 1053 lt0001
trt C 25655 01986 971 1292 lt0001
Week BMR Control
trtweek B 1 36311 03511 781 1034 lt0001 trtweek C 1 43088 03436 778 1254 lt0001
trtweek B 2 24079 0336 867 717 lt0001 trtweek C 2 34088 03296 863 1034 lt0001
trtweek B 3 2197 02963 83 741 lt0001 trtweek C 3 27265 0292 83 934 lt0001
trtweek B 4 19545 031 77 63 lt0001 trtweek C 4 25088 03054 77 821 lt0001
trtweek B 5 18636 03891 769 479 lt0001 trtweek C 5 27147 03833 769 708 lt0001
trtweek B 6 19394 03652 742 531 lt0001 trtweek C 6 25415 03613 745 703 lt0001
trtweek B 7 19545 04398 79 444 lt0001 trtweek C 7 24457 04361 795 561 lt0001
trtweek B 8 18667 03469 898 538 lt0001 trtweek C 8 2386 03477 909 686 lt0001
trtweek B 9 1862 02864 99 65 lt0001 trtweek C 9 22783 02887 100 789 lt0001
trtweek B 10 16119 02678 110 602 lt0001 trtweek C 10 20759 02693 110 771 lt0001
trtweek B 11 17554 02907 111 604 lt0001 trtweek C 11 21972 02906 110 756 lt0001
trtweek B 12 19263 02849 110 676 lt0001 trtweek C 12 20889 02852 110 733 lt0001
trtweek B 13 20389 02982 104 684 lt0001 trtweek C 13 21636 02986 104 725 lt0001
trtweek B 14 24102 03613 932 667 lt0001 trtweek C 14 23985 03666 941 654 lt0001
trtweek B 15 21555 03525 782 611 lt0001 trtweek C 15 22394 03568 785 628 lt0001
Data S et WORKMIL K
Depend ent Vari able mun
Standard
trt week Estimate Error DF t Value Pr gt |t|
B 114104 01671 176 683 lt0001
C 115008 01664 176 6912 lt0001
Week BMR Control
B 1 100091 05855 681 1709 lt0001 C 1 106971 05695 68 1878 lt0001
B 2 103504 04588 745 2256 lt0001 C 2 118206 04471 743 2644 lt0001
B 3 107061 03587 796 2985 lt0001 C 3 116618 03534 796 33 lt0001
B 4 107697 03827 753 2814 lt0001 C 4 116235 0377 753 3083 lt0001
B 5 111909 04262 76 2626 lt0001 C 5 99206 04198 76 2363 lt0001
B 6 115818 04378 727 2646 lt0001 C 6 105217 04358 728 2414 lt0001
B 7 112364 04213 692 2667 lt0001 C 7 114636 04203 693 2728 lt0001
B 8 12197 05044 719 2418 lt0001 C 8 115211 05107 721 2256 lt0001
B 9 114463 04455 725 2569 lt0001 C 9 120648 04523 725 2667 lt0001
B 10 117976 04087 703 2887 lt0001 C 10 117886 04099 702 2876 lt0001
B 11 118609 04981 694 2381 lt0001 C 11 114241 04928 691 2318 lt0001
B 12 11827 03721 748 3178 lt0001 C 12 113556 03715 748 3057 lt0001
B 13 118386 0308 667 3844 lt0001 C 13 120653 03079 667 3919 lt0001
B 14 12225 03271 587 3737 lt0001 C 14 126159 03361 59 3753 lt0001
B 15 121193 04964 602 2442 lt0001 C 15 119674 05043 602 2373 lt0001

35 FCM of cows fed BMR or Control corn silage during the transition period

20

25

30

35

40

45

50

55

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Kg

d

Week of Lactation

BMRCSCCS

Wk 1 - 3 Wk 4 ndash 15Variable CCS BMR

CSSE P-

valueCCS BMR

CSSE P-

valueMilk kg 343 375 10 003 453 473 090 01135 FCM kg 388 429 15 006 467 494 11 009

Stone et al 2012 J Dairy Sci 95 6665ndash6676

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

bull Holstein cows (n=85) entering second or greater lactationbull Four treatments (2 x 2 factorial arrangement)

ndash Conventional vs BMR corn silage-based diets beginning 21 d before expected calving through 42 d postpartum

ndash 0 vs monensin at 330 mgd prepartum and 450 mgd postpartum

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

LaCount et al 2018 J Dairy Sci 101(Suppl 2)95-96

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrients

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Strategically use feed additivesspecific nutrientsbull Research supports additional inclusion of certain nutrients and feed

additives in rations for transition cows (close-up and fresh)bull Nutrients

ndash Choline (rumen-protected) ndash helps the liver export fat and improves performancendash Amino acids (protected and analog forms) ndash improved performance and immunityndash Chromium-propionate ndash energy metabolism immune function cytological endometritis

DMI and performancendash ldquoImprovedrdquo trace mineral sources ndash hydroxy forms and organics

bull Decreased oxidative stress improved milk yield improved immune function

bull Additivesndash Monensin ndash improves propionate production energy metabolismhyperketonemia

production postpartum DMI (400 mgd prepartum 450 mgd postpartum in our research)ndash Yeast cultureyeast products ndash improves rumen functiontransitionDMIperformance

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Top ten things to do for healthy and productive transition cows

bull Manage macromineral nutritionDCAD of dry cows especially in the last 2 to 3 weeks before calving to prevent clinical and subclinical hypocalcemia

bull Control energy intake in both far-off and close-up cows ndash not too little not too muchbull Make sure supplying enough metabolizable protein before calvingbull Get the feeding management right every daybull Clean and comfortable housing and fresh waterbull Manage social interactionshierarchybull Manage heat stressbull High quality forage and fermentable diets for fresh cowsbull Strategically use feed additivesspecific nutrientsbull Implement cow- and herd-level monitoring programs

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Types of monitoring

bull Cow-levelndash Seeking to make a diagnosistreatment decision on an

individual animal

bull Herd-levelndash Periodic (eg weekly) evaluation of a representative sample of

cows in a sampling window of interestndash Using as a barometer of the herd

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Potential herd level monitors for transition cow performance and health opportunities

bull Most of dairy industry works on averages

bull Challenges related to nutritionnon-nutritional factors cause increases in variation in DMIperformancemetabolismndash Almost impossible to detect some of these on farms

bull Potential tools for use in monitoring variation in transition cow management and subclinical opportunitiesndash BHBA (ldquogold standardrdquo blood ketone)ndash NEFA (best marker for negative energy balance)ndash Calcium (moving closer to cowside testing)ndash Haptoglobin (acute-phase responsesystemic inflammation)ndash Rumination monitors ndash other electronic monitoringndash Variation in early lactation milk yield Transition Cow Index (TCI)ndash Urine pH ndash only if feeding anionic supplements but can be great monitor of feeding

management

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA

concentration of 12 to 29 mmolL

McArt et al 2012 J Dairy Sci 95 5056ndash5066

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms

0

10

20

30

40

50

60

lt15 ge15 - lt25 ge25 - lt35 ge35

o

f her

ds

Proportion of cowsherd with BHBA ge12 mmolL 3-14 DIM

Lawton et al 2015 JAM

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Approach for monitoring energy-related blood analytes in transition cows

bull Sample sizendash ~ 15 to 20 cows

bull Cows to samplendash Pre-partum 14 to 2 days before calving (NEFA)ndash Post-partum 3 to 14 DIM (BHBA andor NEFA)

bull Sample to takendash Serum (red top) or plasma (green top)ndash Donrsquot shake keep cool

bull What to do with samplendash BHB Precision Extra Meter or other cowside meter for bloodndash NEFA Lab

bull What to do with resultsndash Interpret above cut-pointndash More than 15 above cut-point indicates herd-level problem

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Herd-level impacts of elevated NEFABHB

15 of 15 = 2-3 animals Ospina et al 2010

Metabolite level Herd Alarm

Associated with

PRE-PartumNEFA gt 03 mEqL

15 +36 Disease incidence-12 Pregnancy rate- 240 kg ME305 milk (both heifers and cows)

POST-PartumNEFA gt 06a - 07b mEqL

15 +17 Disease incidenceb

- 09 Pregnancy ratea

Heifers -291 kg Cows - 577 kg

POST-PartumBHB gt 10a-12b mmolL

15

20

+18 Disease incidenceb

-08 Pregnancy rateb

Heifers -535 kg Cows - 332 kga

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43

Thanks

tro2cornelledu

  • Transition cow nutrition and management to optimize performance of dairy cattle
  • Transition period goals
  • Shift in mindset from the transition cow as a disease opportunity to the transition cow as a production and reproduction opportunity
  • Incomplete list of current ldquohot topicsrdquo in transition cow nutritionmetabolism
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Subclinical hypocalcemia risks
  • Prepartum dietary management is most effective way of preventing postpartum hypocalcemia
  • Slide Number 9
  • Slide Number 10
  • Slide Number 11
  • Synthetic Zeolite A fed during the prepartum period
  • Calcium
  • Top ten things to do for healthy and productive transition cows
  • Summary guidelines -- dry period nutritional strategies
  • General recommendations ndash one-group nutritional strategies
  • Top ten things to do for healthy and productive transition cows
  • Keys to feeding management of dry cow TMR
  • Slide Number 19
  • Recommendations and particle size distributions for 74 Prefresh TMR samples using the Penn State Particle Separator (n=72 farms Lawton et al 2015)
  • Slide Number 21
  • Slide Number 22
  • Top ten things to do for healthy and productive transition cows
  • Top ten things to do for healthy and productive transition cows
  • Cooling during the entire dry period increases subsequent milk production (differences in lbsd above bars)
  • Heat stress in utero has the following effects on the calf (Dahl)
  • Top ten things to do for healthy and productive transition cows
  • BMR corn silage during the transition period
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 32
  • Slide Number 33
  • Top ten things to do for healthy and productive transition cows
  • Strategically use feed additivesspecific nutrients
  • Top ten things to do for healthy and productive transition cows
  • Types of monitoring
  • Potential herd level monitors for transition cow performance and health opportunities
  • Histogram of prevalence of subclinical ketosis (SCK) in 1717 Holstein dairy cows undergoing repeated testing for ketosis from 3 to 16 DIM A positive test was defined as a blood BHBA concentration of 12 to 29 mmolL
  • Prevalence of hyperketonemia between 3 and 14 DIM on 71 commercial dairy farms
  • Approach for monitoring energy-related blood analytes in transition cows
  • Herd-level impacts of elevated NEFABHB
  • Slide Number 43