treatment options resources prostate cancer navigatorpatient · tell your doctor right away if you...

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Quality

Patient Education

Materials

Serving the Oncology

Community


Community

Trusted

Patient Education

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Community

Information and resources that provide support to patients, caregivers, and the oncology professionals who treat advanced prostate cancer

Prostate Cancer Navigator Patient

Guide

Activated immune cells...

...attack prostate

cancer cells

IndIcatIon: PROVENGE® (sipuleucel-T) is approved by the FDA as an autologous cellular immunotherapy for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer. Important Safety InformatIon: PROVENGE is made from your own immune cells. Your cells will be collected at a cell collection center approximately 3 days before each scheduled infusion of PROVENGE. There can be risks associated with the cell collection process, which you should discuss with your doctor before deciding to begin treatment with PROVENGE. PROVENGE can cause serious reactions. In controlled clinical trials for the treatment of prostate cancer, serious reactions reported in patients in the PROVENGE group included reactions resulting from the infusion of the drug, which occurred within 1 day of infusion, and strokes. Severe infusion reactions included chills, fever, fatigue, weakness, breathing problems (shortness of breath, decreased oxygen level, and wheezing), dizziness, headache, high blood pressure, muscle ache, nausea, and vomiting. Tell your doctor right away if you have breathing problems, chest pains, racing heart or irregular heartbeats, dizziness, nausea, or vomiting after getting PROVENGE, because any of these may be signs of heart or lung problems. The most common side effects reported with PROVENGE were chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor. Tell your doctor about all your medical problems, including heart problems, lung problems, or a history of stroke. Tell your doctor right away if you get a fever over 100°F, or redness at the cell collection or infusion sites, because any of these may be signs of infection. Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements. Tell your doctor about any side effect that concerns you or does not go away. For more information on PROVENGE, please see the full Prescribing Information or call Dendreon ON Call at 1-877-336-3736. Please see Important Patient Information about PROVENGE on the next page.

The power To fighT advanced prostate cancer is already in you. turn it on.

get your immune system into the fight. Talk to your doctor about proVenge today.

To watch a video about PROVENGE, scan the QR code or visit www.PROVENGEinfo.com

proVenge activates your immune system.

©2012 Dendreon Corporation. All rights reserved. March 2012. P-A-06.11-110.04

5547_Educated_Patient_L2.indd 1-2 4/5/12 5:29 PM

Important InformatIon for patIents

Important safety information about proVenGe® (sipuleucel-t)

This brief summary does not contain all the information that may be of interest to you and does not take the place of talking with your doctor or healthcare professional about your medical condition or your treatment. If you have any questions, speak with your doctor.

This information is designed to help you understand treatment with PROVENGE (pronounced PROH-venj).

What is proVenGe?

PROVENGE is a prescription medicine that is used to treat certain patients with advanced prostate cancer. PROVENGE is made from your own immune cells. The typical course of treatment is 3 infusions.

What should I tell my doctor before getting proVenGe?

Tell your doctor about all your medical problems, including:

• heart problems • lung problems • history of stroke

Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements.

What are the possible or reasonably likely side effects of proVenGe?

The most common side effects of PROVENGE include:

• chills • back pain • nausea • fatigue • headache • joint ache • fever

PROVENGE infusion can cause serious reactions. Tell your doctor right away if you have any of the following reactions after getting PROVENGE because they may be signs of heart or lung problems:

• breathing problems • dizziness • chest pains • nausea or vomiting • racing heart or irregular heartbeats

Tell your doctor right away if you get a fever over 100°F, or redness or pain at the infusion or collection sites, because any of these may be signs of infection.

Tell your doctor about any side effect that concerns you or does not go away.

These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor.

What are safety concerns from treatment with proVenGe?

Each manufactured dose of PROVENGE is checked for quality prior to infusion. Once manufactured, PROVENGE has a strict expiration time and must be infused within a certain number of days. Infusion of PROVENGE typically occurs before a final test result for product sterility is available. There is a risk that you may receive an infusion that is later found not to be sterile. Your doctor would be contacted if this occurs and determine how best to treat you.

If you have questions or concerns or want more information on PROVENGE, contact your doctor.

Additional information can be found at www.PROVENGE.com or you may call the Dendreon toll-free number: 1-877-336-3736.

You are encouraged to report negative side effects of prescription drugs to fDa. Visit www.fda.gov/medwatch or call 1-800-fDa-1088.

rx only

Dendreon Corporation Seattle, Washington 98101 P-A-03.11-016.01

T: 3.9375 x 10.75 Color: Black5547_Educated_Patient_BS_L2.indd 1 4/5/12 5:30 PM

Copyright © 2012 intellisphere, LLC. all rights reserved.

a diagnosis of advanced prostate cancer means that

the cancer has spread beyond the male prostate gland

into another area of the body.1 the diagnosis can be life

changing and overwhelming. However, understanding the

disease can assist patients as they work one-on-one with

their physician.

this support and assistance guide briefly discusses

advanced prostate cancer and highlights organizations

that provide support to those affected by the disease.

the content and resources in this guide offer information

related to understanding the disease and treatment

options available to the patient, as well as offer assistance

to the patient and caregiver.

the websites in this guide provide direct support services

including toll-free hotlines, as well as a tremendous

amount of downloadable resources such as brochures,

videos, and books specific to advanced prostate cancer.

those affected by the disease may also learn to cope

simply by joining active online message boards.

We sincerely hope that this guide will assist you

emotionally and help you select the right treatment

options with your physician.

Knowledge to DecideUnderstanding advanced prostate cancer as an aid to working with your physician

to download a PdF of this Patient navigator, visit www.OncLive.com.

5

Advanced Prostate Cancer InformationAbout Advanced Prostate Cancer

the prostate gland is a walnut-sized organ located under the bladder and in front of the rectum. the prostate surrounds part of the urethra, which is the thin tube that carries urine from the bladder through the penis and out of the body. the prostate makes seminal fluid, which carries sperm.2

Prostate cancer is the most common cancer in american men.2 Once prostate cancer spreads beyond the prostate gland into another part of the body, a patient has developed advanced prostate cancer, also termed metastatic prostate cancer.1

When prostate cancer cells spread, they typically first affect the lymph nodes in the pelvis. these cells are more likely to spread to other portions of the body, including a patient’s bones.2 the bones, lungs, and liver are the most common areas of the body affected by metastasis.3

the incidence of prostate cancer increases with age. Family history may also increase the overall risk of prostate cancer. it is more significant if a family member was diagnosed with prostate cancer at a younger age (less than 60 years). the incidence rate of prostate cancer is 2 times higher in african american men compared with Caucasian men.4

Urethra

Bladder

Prostate

Rectum

adapted from Cancer.gov3

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Symptoms of Advanced Prostate Cancer

Commonly, men who have developed advanced prostate cancer may find blood in their urine or semen. Other urinary problems include the need to urinate more often, or a slow or weak urinary stream. difficulty having an erection may also occur. another common symptom of advanced prostate cancer is pain in the back or hips.5 Bone pain, weight loss, and swelling in your legs and feet may also occur.6

Males experiencing any of these symptoms should contact their health care professional right away. it is important not to ignore these symptoms, as prostate cancer grows slowly and often does not send signals during its early stages.5

Determining Advanced Prostate Cancer

Your health care professional will test you to help determine if prostate cancer has metastasized.

the prostate-specific antigen (PSa) test is used to detect prostate cancer. the screening measure checks for elevated levels of PSa, a substance created by the prostate, in a patient’s blood.5 the PSa test may be used to monitor the progression of the disease and can help determine the effectiveness of various treatments.7

Health care professionals also commonly suggest a biopsy, magnetic resonance imaging (MRi) test, or computerized tomography (Ct) scan.2

a biopsy is the removal of cells or tissue for microscopic examination. usually done with the use of a local anesthetic, a biopsy is the only sure way to diagnose prostate cancer.5,6

an MRi or Ct test can be used to determine if cancer spreads to another section of the body. the tests can also determine if the cancer has recurred after treatment.6

Understanding the Stages of Advanced Prostate Cancer

if you have recently been diagnosed with advanced prostate cancer, it is important that you understand the stages of prostate cancer so you may work one- on-one with your physician to determine the most effective treatment plan. doctors determine the proper treatment and help predict likely outcomes based on a patient’s stage classification. a biopsy test will help determine the stage of the cancer.5

Stage iii or iV prostate cancer is considered advanced prostate cancer, meaning the tumor extends outside of the prostate and involves nearby tissues such as lymph nodes or the bladder. Stage iii is also known as locally advanced prostate cancer because the cancer has spread but is still confined to the prostate area. Stage iV prostate cancer can be either regional, meaning it has spread to nearby lymph nodes but has not spread to other portions of the body, or distant, meaning the cancer has spread to distant lymph nodes, bone, or other organs.2,5,6

a biopsy test will also determine the grade of the cancerous tumor. the higher its score, the more likely it is to spread.2

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Treatment Options for the Advanced Prostate Cancer Patient

Once the stage is determined, the patient will discuss the best treatment option with his physician. developing a treatment plan will depend on a patient’s age, diagnosis, and symptoms, as well as the patient’s current health conditions and how he may react to the possible side effects caused by treatment.2

after the initial diagnosis of prostate cancer, some men may be treated with surgery to remove the prostate while others may be treated with radiation therapy. Radiation therapy can be given through external beam radiation, radioactive seeds, or a combination of both.1

after surgery or radiation therapy, PSa levels are moni-tored. if PSa levels begin to rise, the cancer may be coming back. at this point, a doctor may recommend hormone therapy. there are several types of hormone therapy. Patients may receive 1 or several kinds depend-ing on what the doctor determines best. as a result of hormone therapy, PSa levels should remain low.1

if the cancer has spread outside the prostate gland, metastatic, advanced disease may occur. a physician may choose immunotherapy if the patient has had few or no prostate cancer pain—related symptoms. For men who have significant cancer-related pain, chemotherapy is an option.1

after 1 type of chemotherapy, a different type of che-motherapy or a different hormone therapy are options.1

diagnosis

RisingPSa

RisingPSa

Spread to Other Parts of the Body

disease Progression

disease Progression

Surgery or Radiation therapy

Hormone therapy

immunotherapy

Chemotherapy

Secondary Chemotherapy

or Hormone therapy

Advanced Prostate CancerProstate Cancer

1

2

4

3

Source: Provenge.com1

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Understanding Your Treatment Options

Hormone TherapyMale hormones such as testosterone fuel the growth of prostate cancer. By reducing the amount and activity of these hormones doctors can slow the growth of advanced prostate cancer.6

Hormone therapy is the main treatment for advanced prostate cancer and is the first treatment usually offered if the cancer has spread.6 also called androgen-deprivation therapy, this therapy blocks the production of androgens, which helps slow the growth of a tumor.5

Hormone therapy helps provide temporary relief of symptoms of advanced prostate cancer. it also reduces tumor size and levels of PSa in most men. eventually most patients with advanced prostate cancer stop responding to hormone therapy. doctors call this hormone-refractory prostate cancer.6

Immunotherapyimmunotherapy is a treatment option that uses the body’s own immune system to help fight cancer. an immune system is made up of cells found in a person’s blood that work as the body’s natural defense against all types of illnesses.1,7

immunotherapy can stimulate a patient’s immune system to work harder and smarter. the treatment supplies the body with immune system components, such as immune system proteins. immunotherapy is sometimes used by itself to treat cancer, but it is most often used along with or after another type of treatment to boost its effects.8

Cancer treatment vaccines are different from preventative vaccines, such as polio or measles vaccines. Preventative vaccines help to prevent infection by stimulating the immune system to recognize and attack infectious agents, such as bacteria or viruses. On the other hand, cancer treatment vaccines are used during immunotherapy to stimulate the body’s own immune cells to attack cancer cells that already exist in the body. this may help a patient live longer.1

ChemotherapyProstate cancer chemotherapy is almost always used for advanced prostate cancer when the patient has stopped responding to hormone therapy.6 Chemotherapy treatment uses drugs to help stop or slow the growth of cancer cells. this type of therapy may keep cancer from spreading, as it helps destroy cancer cells.3

Chemotherapy can harm healthy cells that divide quickly, such as those that line the mouth and intestines, or those that cause hair to grow. damage to healthy cells may cause side effects. Often, side effects get better or go away after chemotherapy has ended.3

Radiation TherapyProstate cancer that has spread can be treated with radiation therapy. this type of therapy helps to relieve the pain. Radiation therapy uses high-energy x-rays or protons to destroy cancer.6 there are several different types of radiation therapies. a radiation oncologist will help to prescribe a patient with their treatment option after evaluating their cancer and general health.3

Radiation therapy usually is combined with hormone therapy when used to treat advanced prostate cancer.6

SurgerySurgery is the removal process of either a tumor or an area affected by cancer blockage.6 Surgery is most common in early stages of prostate cancer, and followed by hormone therapy. Surgery may sometimes be recommended for advanced prostate cancer if it is considered locally advanced.1,2

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Us TOO International Prostate Cancer Education and Support Network

www.ustoo.org • 630-795-1002

us tOO is a non-profit prostate cancer education and support network comprising 325 support group chapters worldwide. us tOO’s mission is to assist men and their families to make informed decisions about prostate cancer, early detection, and treatment. actively working as an advocate, the organization also is committed to ensuring that patients have access to the programs, medications, treatments, and health care professionals they need.

Family and CompanionsProvides an online support forums link which matches experts with those affected by advanced prostate cancer through the Prostate Pointers online community. the community features 14 focused and moderated e-mail discussion lists, an event calendar, and links to thousands of physician-contributed web pages.

Advanced DiseaseOffers information specific to advanced prostate cancer and allows viewers the option to download us tOO’s advanced Prostate Cancer disease Resource Kit. the kit includes material specific to advanced prostate cancer.

Helpful Resources: Advanced Disease or RecurrenceResources for advanced patients, as well as their caregivers, may also be downloaded, or ordered and shipped.

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Education - Testing And DiagnosisProvides important information including the risk factors, symptoms, understanding the testing procedures and their importance, and summarizes the diagnosis process of prostate cancer.

Education - Living with CancerOffers insight related to diet, sexual health, and incontinence, and provides resources, as well as other personal care information including tips on how to cope daily with prostate cancer.

Getting the Support You Need - FinanicalFound on the Living With Cancer web page, this section offers links to a variety of tools for the advanced prostate cancer patient and caregiver. Financial assistance, advance directives and wills, hospice, and palliative care information is provided here.

ZERO—The Project to End Prostate Cancer

zerocancer.org • 202-463-9455

ZeRO’s name conveys the message that the organization has no tolerance for prostate cancer. ZeRO is committed to creating a future where men who have been diagnosed with prostate cancer will be cured, or will manage their illness with a good quality of life. ZeRO works to increase research funding from the federal government to find new treatments and ultimately find a cure for prostate cancer.

Activated immune cells...

...attack prostate

cancer cells

IndIcatIon: PROVENGE® (sipuleucel-T) is approved by the FDA as an autologous cellular immunotherapy for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer. Important Safety InformatIon: PROVENGE is made from your own immune cells. Your cells will be collected at a cell collection center approximately 3 days before each scheduled infusion of PROVENGE. There can be risks associated with the cell collection process, which you should discuss with your doctor before deciding to begin treatment with PROVENGE. PROVENGE can cause serious reactions. In controlled clinical trials for the treatment of prostate cancer, serious reactions reported in patients in the PROVENGE group included reactions resulting from the infusion of the drug, which occurred within 1 day of infusion, and strokes. Severe infusion reactions included chills, fever, fatigue, weakness, breathing problems (shortness of breath, decreased oxygen level, and wheezing), dizziness, headache, high blood pressure, muscle ache, nausea, and vomiting. Tell your doctor right away if you have breathing problems, chest pains, racing heart or irregular heartbeats, dizziness, nausea, or vomiting after getting PROVENGE, because any of these may be signs of heart or lung problems. The most common side effects reported with PROVENGE were chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor. Tell your doctor about all your medical problems, including heart problems, lung problems, or a history of stroke. Tell your doctor right away if you get a fever over 100°F, or redness at the cell collection or infusion sites, because any of these may be signs of infection. Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements. Tell your doctor about any side effect that concerns you or does not go away. For more information on PROVENGE, please see the full Prescribing Information or call Dendreon ON Call at 1-877-336-3736. Please see Important Patient Information about PROVENGE on the next page.

The power To fighT advanced prostate cancer is already in you. turn it on.

get your immune system into the fight. Talk to your doctor about proVenge today.

To watch a video about PROVENGE, scan the QR code or visit www.PROVENGEinfo.com

proVenge activates your immune system.

©2012 Dendreon Corporation. All rights reserved. March 2012. P-A-06.11-110.04

5547_Educated_Patient_L2.indd 1-2 4/5/12 5:29 PM

Important InformatIon for patIents

Important safety information about proVenGe® (sipuleucel-t)

This brief summary does not contain all the information that may be of interest to you and does not take the place of talking with your doctor or healthcare professional about your medical condition or your treatment. If you have any questions, speak with your doctor.

This information is designed to help you understand treatment with PROVENGE (pronounced PROH-venj).

What is proVenGe?

PROVENGE is a prescription medicine that is used to treat certain patients with advanced prostate cancer. PROVENGE is made from your own immune cells. The typical course of treatment is 3 infusions.

What should I tell my doctor before getting proVenGe?

Tell your doctor about all your medical problems, including:

• heart problems • lung problems • history of stroke

Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements.

What are the possible or reasonably likely side effects of proVenGe?

The most common side effects of PROVENGE include:

• chills • back pain • nausea • fatigue • headache • joint ache • fever

PROVENGE infusion can cause serious reactions. Tell your doctor right away if you have any of the following reactions after getting PROVENGE because they may be signs of heart or lung problems:

• breathing problems • dizziness • chest pains • nausea or vomiting • racing heart or irregular heartbeats

Tell your doctor right away if you get a fever over 100°F, or redness or pain at the infusion or collection sites, because any of these may be signs of infection.

Tell your doctor about any side effect that concerns you or does not go away.

These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor.

What are safety concerns from treatment with proVenGe?

Each manufactured dose of PROVENGE is checked for quality prior to infusion. Once manufactured, PROVENGE has a strict expiration time and must be infused within a certain number of days. Infusion of PROVENGE typically occurs before a final test result for product sterility is available. There is a risk that you may receive an infusion that is later found not to be sterile. Your doctor would be contacted if this occurs and determine how best to treat you.

If you have questions or concerns or want more information on PROVENGE, contact your doctor.

Additional information can be found at www.PROVENGE.com or you may call the Dendreon toll-free number: 1-877-336-3736.

You are encouraged to report negative side effects of prescription drugs to fDa. Visit www.fda.gov/medwatch or call 1-800-fDa-1088.

rx only

Dendreon Corporation Seattle, Washington 98101 P-A-03.11-016.01

T: 3.9375 x 10.75 Color: Black5547_Educated_Patient_BS_L2.indd 1 4/5/12 5:30 PM

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Prostate Conditions Education Councilwww.prostateconditions.org • 303-316-4685

the Prostate Conditions education Council (PCeC) reaches out to a variety of demographic populations, including physicians, patients, and caregivers, to increase awareness and provide them with up-to-date information regarding the disease, including treatment options. PCeC also provides access to free early detection for prostate cancer, including the evaluation for advanced cancer patients.

Prostate CancerOffers educational information related to prostate cancer through links including screening and prevention, early detection, treatment, and advanced disease.

Advanced DiseaseSummarizes the 4 different categories of advanced prostate cancer, as well as explains the physician’s process in testing for advanced prostate cancer.

Screeningthe Find a Screening Site link helps visitors easily search for a location to be tested for prostate cancer.

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Prostate Health Education Network, Incwww.prostatehealthed.org • 781-487-2239

the Prostate Health education network, inc (PHen) focuses on men at the highest risk for prostate cancer in the united States, including african americans and men with a family history. in addition to eliminating the african american prostate cancer disparity, its advocacy efforts help to increase the overall support and resources to help fund prostate cancer research.

Local SupportVisitors may search for local PHen Focus cities. Selecting a local city will offer the viewer information regarding local support groups close to home.

PHEN TVPHen tV programs discuss many different issues related to prostate cancer. Visitors will see a brief description next to each video listed in this section and may click on the video if they are interested in learning more.

Treatment CentersHighlights information about treatments and local treatment centers for the purpose of education and awareness. the information helps patients discuss their options with their health care providers.

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Decision AideProvides in-depth information through links such as where to start, finding if you have prostate cancer, understanding your diagnosis, local treatments, if prostate cancer returns, side-effects, and alternatives, all related to prostate cancer.

ResourcesFrom an online video directory to a listing of books about prostate cancer, this section offers educational assistance to patients and caregivers. Links for clinical trials and assistance in finding expert physicians are also found on this page.

Blue Community - What’s Your Shade? the color blue represents prostate cancer. the Blue Community web page is filled with content discussing the types of prostate cancer, treatment options, and provides navigation links to blogs and support groups. Visitors may become free members of PCRi, and can post questions and provide insights for others to read.

Prostate Cancer Research Institutewww.prostate-cancer.org • 310-743- 2116

the Prostate Cancer Research institute (PCRi) was founded by 2 internationally recognized oncologists who share a mission to help improve men’s lives by supporting research and disseminating information that educates and empowers patients, families, and the medical community. PCRi believes that a patient who understands his disease and options can communicate more effectively with his physicians.

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National Physician and Family Referral Project

www.npfrproject.org • 800-677-8441

the national Physician and Family Referral Project (nPFR) partners with over 103 national and local community-based organizations and conducts patient education and patient advocacy programs to improve health matters for minority and underserved communities. the nPFR educates about health, disease, and clinical trials.

About C.E.D.R.I.C.T.nPFR’s field research project, Coalition to eliminate disparities and to Research inclusion in Clinical trials (C.e.d.R.i.C.t.), gathers information about health education needs and access to clinical trials through surveys of large groups in over 20 major cities.

Partnered Clinical Trials Education EventsHighlights upcoming nPFR events that help create awareness and increase minority participation in prostate cancer– related clinical trials.

African American Health Matters nPFR’s companion website, african american Health Matters (aaHM), was developed as a project to allow visitors to easily submit their name and mobile phone number to become part of its monthly and bi-monthly text messaging health tips service.

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Patient Resources1

ADVOCACY ORGANIZATIONS

Abigail Alliance 703-646-5306 www.abigail-alliance.org

CancerCare 800-813-HOPe www.cancercare.org

Chronic Disease Fund 877-968-7233 972-608-7141 www.cdfund.org

Malecare 212-673-4920 www.malecare.org

Men’s Health Network 202-543-MHn-1 ext. 101 www.menshealthnetwork.org

National Alliance of State Prostate Cancer Coalitions 877-naSPCC-8 www.naspcc.org

National Coalition for Cancer Survivorship (NCCS) 301-650-9127 www.canceradvocacy.org

The Prostate Net 888-477-6763 www.prostate-online.com

Cancer Support Community 202-659-9709 www.cancersupportcommunity.org

Wellness Place 847-221-2400 www.wellnessplace.org

Women Against Prostate Cancer 202-580-5730 www.womenagainstprostatecancer.org

PROFESSIONAL SOCIETIES

American Cancer Society (ACS) 800-aCS-2345 www.cancer.org

American Urological Association 800-828-7866 www.urologyhealth.org

American Society of Clinical Oncology (ASCO®): People Living With Cancer 571-483-1780 www.cancer.net/portal/site/patient

ADDITIONAL RESOURCES

Clinical Trials 800-4-CanCeR www.clinicaltrials.gov

EmergingMed 877-601-8601 www.emergingmed.com

National Cancer Institute (NCI) 800-4-CanCeR www.cancer.gov

Additional Assistancedendreon, the maker of PROVenGe, offers support

through its Dendreon On Call service. Dendreon On Call

is staffed by a team of specialists who provide support to

doctor’s offices throughout patients’ treatments.7

a patient’s doctor’s office will work with Dendreon On

Call to create a personalized treatment schedule for

PROVenGe therapy. in addition to scheduling help,

dendreon’s patient assistance programs may help cover

the costs of PROVenGe treatment.1

dendreon supplies grants to independent foundations

that provide financial assistance and other support to

men with prostate cancer. Dendreon On Call offers

general insurance coverage information to help patients

understand their options. the service helps refer patients

to appropriate independent foundations that provide

financial assistance for co-pays, co-insurance, and

deductible costs, as well as help patients find assistance

with treatment-related travel costs. in addition, the

service provides support to patients who do not have

coverage for PROVenGe. eligibility criteria include a

household-adjusted gross income of $150,000 or less,

united States residence, and on-label prescription for

PROVenGe. Dendreon On Call may be reached toll-free

at 1-877-336-3736.1

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Glossary of Terms 7

Asymptomatic: having no symptoms. this means having no prostate cancer–related pain and not needing narcotics to lessen cancer-related pain

Autologous: comes from you. an autologous treatment is made from cells that come from your body

Castrate-Resistant (Hormone-Refractory) Cancer: cancer that does not respond to hormone treatment or that gets worse while being treated with hormone therapy

Cellular: made of cells. a cellular treatment is made of the man’s own cells

Central Venous Catheter: a long, thin, flexible tube put into a vein in the arm or chest that goes to a large vein near the heart

Complete Blood Count (CBC): a test that measures the amount of different types of blood cells

Fatigue: a feeling of weariness and tiredness

Hormone Therapy: treatment that decreases the level of hormones in the body

Immunotherapy: treatment that helps the immune system (the body’s natural defense) fight disease

Infusion: the act of putting fluid (usually a medication) into a vein

Leukapheresis: the process of removing some white blood cells from the blood of a patient and returning the rest of the cells to the patient’s body

Metastatic: spread from the original location to other parts of the body; in prostate cancer, cancer that has spread from the prostate to places such as the bones minimally

Narcotics: substances that relieve pain

Nausea: feeling sick to the stomach, often accompanied by an urge to vomit

Prostate-Specific Antigen (PSA): a protein made by the prostate gland and by prostate cancer. a test for PSa is often used to screen for prostate cancer and to monitor some treatments for the disease

Recombinant Antigen: a protein that is designed to produce an immune response

Sterility: being free from living germs and other microscopic organisms

Symptomatic: having minor symptoms. this means having relatively little prostate cancer–related pain and not needing narcotics to treat cancer-related pain

T Cells: a type of immune cell that helps the immune system fight disease such as viral infections and cancer

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Advanced Prostate Cancer References1. PROVenGe (sipuleucel-t) website. dendreon

Corporation.

http://www.provenge.com. accessed april 24, 2012.

2. national Cancer institute. What You Need to Know

About Prostate Cancer [online booklet]. Rockville,

Md: uS department of Health and Human Services;

2008. https://cissecure.nci.nih.gov/ncipubs/detail.

aspx?prodid=P035. accessed

april 24, 2012.

3. Cancer topics section. national Cancer institute

website. www.cancer.gov/cancertopics. accessed

april 24, 2012.

4. Prostate Cancer section. Prostate Conditions education

Council website. http://www.prostateconditions.org/

prostate-conditions/prostate-cancer. accessed

april 23, 2012.

5. Prostate Cancer section. american Cancer Society, inc

website. http://www.cancer.org/Cancer/ProstateCancer/

index?ssSourceSiteid=null. accessed april 24, 2012.

6. Prostate Cancer section. WebMd, LLC website.

http://www.webmd.com/prostate-cancer/default.htm.

accessed april 23 and april 24, 2012.

7. The Power To Fight Advanced Prostate Cancer Is

Already In You. Turn It On: Learning About Your

Treatment for Advanced Prostate Cancer [PROVenGe

patient brochure]. Seattle, Wa: dendreon Corporation;

2011. http://www.provenge.com/pdf/PROVenGe_

Overview.pdf. accessed april 24, 2012.

8. Find Support and treatment section. immunotherapy

page. american Cancer Society, inc website. http://

www.cancer.org/treatment/treatmentsandSideeffects/

treatmenttypes/immunotherapy/immunotherapy-what-

is-immunotherapy. accessed april 24, 2012.

Notes

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the information in this guide is designed to be a summary of information and not an exhausted list of available resources.

intellisphere Oncology Specialty Group was primarily responsible for selecting

the content in this supplement.

treatment options resources prostate cancer navigatorpatient · tell your doctor right away if you...

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