trends in technology and applications · adhesives adhesive peptides lignocellulose butanol ethanol...
TRANSCRIPT
Trends in Technology and Applications
Dr. Manfred Kircher Chairman CLIB2021
January 13th, 2010
OECD Workshop on the Outlook on Industrial Biotechnology Vienna
State of the Art
Emerging Trends
Priorities
Coordinating the Development
Supporting Measures by Governments and Industry
Biotechnology is Key
in Biobased Production
Oils & Fats
Starch
Cellulose
Saccharose
Other
Fossil Oil
80%
Coal
8%
Natural Gas
2%
BioRenewable
Feedstocks
10%
0 5 10 15 20 25
bio $
15 % Products from
Chemical Processes
10 % BioCatalytic
Microbes & Enzymes
75 % Products
from Biotech-Processes
30 bio $; USA (2007) USITC publication 4020: „Industrial Biotechnology:
Development and adoption by the US Chemicals and Biofuel industries“ July 2007 Germany 2008; Source: VCI
85% Bio-based Chemical Sales
Based on Biotechnology
2 mio t/a BioRenewable Feedstocks
are Exploited by the Chemical Industry
0 5 10 15 20 25 30 35 40 45 50
Annual Sales of the German Chemical Industry (€ bio; 2007)
Blue: Biotechnological products established
Source: VCI 2009
Polymers
Pharmaceuticals
Fine & Special Chemistry
Petrochemicals and Derivates
Detergents & Bodycare
Anorg. Basic Chemistry
Biotechnology is Established
in the Chemical Industry…
94%
ChemoProducts
6%
BioProducts
..but still a Niche
Midwest Lysine LLC, Blair Neb.USA
Available only by Biotechnology:
L-Lysin for Feed, Food & Pharma
aqueous
waste
raw mat.
reaction
desodor.
bleaching
drying
filtration
packing
volatile
comp.
aqueous
waste
solid
waste
Conventional
> 180°C
140°C
100°C
60°C
20°C
temperature
catalyst
recycled
Enzymatic
reaction
raw mat.
packing
Biotechnology is More Competitive:
Emmolients (Cosmetic Esters)
catalyst
bleach
steam
Most established Processes
are pure BioCatalysis
BioRenewable Feedstock
BioCatalysis
Product
Current Industrial Biotechnology
is Based on Pathways given by Nature
Amino acids
Organic acids
Fuels
&
Solvents
Biotechnological Products
are established in higher value business segments
Feedstock BioCatalysis Products
Strengths & Weaknesses
• theoretical productivity & yield
not fully exploited
• insufficient genetic stability
• enzymatic catalysis
limited to hydrolases
• product removal & purification
costly
• insufficient
feedstock
flexibility
• limited to
biological
products
• limited to
natural pathways
State of the Art
Emerging Trends
Priorities
Coordinating the Development
Supporting Measures by Governments and Industry
Biorenewable Feedstocks Compete
with Petrochemical Carbon Sources
OHOH
O
O
CH2
OHCH
3
O
O OO
OH
OH OH
OH
OHOH
OH
OH
OH
OH
OH OH
OH
OH
OH
OHOH
O
OO
OH
O
OH OH OH
O
OHOH
O
ONH2
OHOH
O
OH
OH
OH
OH
O
OH OH
O
NH2
O
succinic acid 3-hydroxypropionic
acid
2,5-furandicarboxylic
acid
aspartic acid glutamic acidglucaric acid
itaconic acid
glycerol
levulinic acid
sorbitol
3-
hydroxybutyrolactone
xylitol
Fig. 2 DOE „TOP12“ Platform Chemicals from
Carbohydrates [8]
Organic Chemicals
Pharmaceuticals
Fine & Specialty Chemistry
Detergent & Hygiene Chemicals
Polymers
Petrochemicals & Derivatives
Agrochemicals
Corn
The Chemical Industry
gets ready for launching the KBBE
Company Carbon Source BioProduct Product
Braskem
BRA Sugar
Ethanol
200 kt Ethylene
HDPE 2010
Perstorp
SWE Starch/Sugar 3-Hydroxy-
propionic acid
(meth)acrylic acid/
1,3-PDO 2012
Isoprene Rubber 2013
Dow/Crystalsev
BRA Sugar
Ethanol
350 kt
Ethylene
HDPE
2011
Solvay Indba
BRA Sugar
Ethenol
60 kt
Ethylene
PVC 2010
Genencor/Goodyear
USA
Corn cobs
Switchgras
Genomatica
USA Sucrose 1,4-butanediol Platform chemical 2010
03/2009
12/2008
09/2008
09/2008
12/2007
07/2007
Press
Release Launch
0 5 10 15 20 25 30 35 40 45 50
Annual Sales of the German Chemical Industry (€ bio; 2007)
Blue: Biotechnological products established
Blue checkered: Early biotechnological products on the market
Source: VCI 2009
Polymers
Pharmaceuticals
Fine & Special Chemistry
Petrochemicals and Derivates
Detergents & Bodycare
Anorg. Basic Chemistry
BioCatalysis Enters Production
of Polymers
94%
ChemoProducts
6%
BioProducts
Biotechnology and Chemistry
Complement one another
BioRenewable Feedstock
BioCatalysis
Chemistry BioProduct
Product Intermediate
OH HO
H
OH
H OH H
H OH O
H
HO HO
OH
O~ P HO
OH
OH HO OH O
OH HO
OH HO
Escherichia coli
Klebsiella
pneumoniae
Saccharomyces
cerevisiae
1,3 PDO
Technology Push
by Synthetic Biology
Today Biotechnology is based on
Agricultural Carbon Sources
+ aerob fractionation
30%
70% of Biomass Carbon
BioEnergy Markets
will be Dominant
EU
USA
BRA
0
50
2004 2005 2006 2007 2008
Bioethanol-Plant Pischelsdorf
2004 2005 2006 2007 2008
40
30
20
10
0
50
Bioethanol Production
[mio m³]
Germany:
Bioethanol Consumption 2008-2009 +61%
Lignocellulose
is not yet Competitive
+
+
30%
aerob
fractionation
fractionation
aerob
70% of Biomass Carbon
+
80% of Biomass Carbon
20%
Syngas Fermentation
may Provide C4-Platform Chemicals
„Our collection of various acetogens from a variety of diverse ecological niches is a great pool of
genes essential for engineering of microbial catalysts
fermenting syngas to linear (4 - 5 carbons and up) or cyclic carbon backbone
Syngas Biofuels Energy, Inc. Houston 25.8.2009
CO2
CO
H2
Gasification
99 % Carbon Yield
+
+
Total Carbon Share
20-30%
aerob
fractionation
gasification
fractionation
aerob
anaerob
Total Carbon Share
70-80%
+
Total Carbon Yield
>99%%
Biotechnological Products
enter high volume & bulk business segments
Feedstock BioCatalysis Products
Options & Challenges
• availability of „chassis“ cells
• standardization of metabolic modules
• high-through-put (HTP)
cell engineering and screening
• continuous processes
• in situ product recovery (ISPR)
• integration of bio- and chemical
processes
• anaerobic processes and reactors
• economics of
lignocellulosic
carbon sources
• transformation
of syngas
• bioproducts
• precursors for
chemical
production
State of the Art
Emerging Trends
Priorities
Coordinating the Development
Supporting Measures by Governments and Industry
Priorities
• Biological Catalyst – synthetic biology
whole cell and enzymatic catalysis
• Process – continuos processes
– anaerobic processes
– in-situ product recovery (ISPR)
– bio-/chemo process-integration
– process flexibility in biorefineries
• Product Evaluation – standardized life cycle analysis (LCA)
State of the Art
Emerging Trends
Priorities
Coordinating the Development
Supporting Measures by Governments and Industry
Sugar cane
Soy
Corn
Seed
Consumer
Value
Value Chain
Microbial
intermediates
Fatty
acids Plant biomass
Industrial Biotechnology:
Cooperation all over the Value-Chain
Enantiomerically
pure drug
Polyurethane
Polylamides Succinic acid
Amino
Acid
Adhesives Adhesive
Peptides
Lignocellulose
Butanol
Ethanol
Super
absorber
Plastics
Butadiene
Acetaldehyde
Acrolein
Chemical products
Pyridines
Acrylic Acid
Food Additives
Agro-Industry
Feedstock-Supplier
Chemical Industry
Consumer Industries
Diaper
Yoghurt
Cosmetic
Bottle
Wood
Energy
Syngas
C5 Sugars
C6 Sugars
Lignin
Industry 8
SME 34
Academia 13
Investors 5
Infrastructure 10
BioProcess; 14
BioProducts; 11
Equipment; 4
Patents; 2
Consulting; 1Data&Studies; 1
Lawyer; 1
Hachured segments: international members
Industry 8
SME 34
Academia 13
Investors 5
Infrastructure 10
Members of CLIB2021
Include all Stakeholders
State of the Art
Emerging Trends
Priorities
Coordinating the Development
Supporting Measures by Governments and Industry
Supporting Measures
• Financing
– setting off R&D expenses
– public promotion of demo-plants
• Cooperation
– promote partnering in clusters
– promote R&D partnering in prioritized fields
• both by governments and industry
• Training
– promote international exchange of graduates
• in academia and industry
thank you for your attention !