trichogenic complex anti-hair loss active and conditioner...trichogenic complex anti-hair loss...
TRANSCRIPT
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TRICHOGEN® VEG LS 8960Trichogenic complex
Anti-hair loss active and conditioner
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Germinative bulb
Stratum corneum
Epidermis
Dermis
Basal layer
Sebaceousgland
Arrectormuscle
Zone of permanent hair
Keratogenouszone
Area of differentiation and biological synthesis
Physiology of hair
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MicrofibrilMacrofibril
Hair stem
70 A
Protofibril
Exocuticle
Cell membrane complexEndocuticle
CuticuleCortex
50µ 0.7µ
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The hair follicle is the living part of the hair:
- the bulb • Made of cells, similar to basal epidermal layers
• Metabolic activity is important
- the papilla • Median invagination• High vascularization
Bulb
Papilla
Hair follicle
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Hair follicles have a periodic and cyclic activity of growth
Anagen phase 3 yearsCatagen
phase 3 weeksTelogen phase
3 months
HAIR CYCLE
1 2 3 4 5
Physiology of hair follicle
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Anagen Phase(aspect of the bulb)
Telogen Phase(aspect of the bulb)
Cyclic activity can be evaluated by a trichogram
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= keratogenous areaES = epithelial sheathIES = inner epithelial sheathOES = outer epithelial sheathg = germinative cellsp = dermal papilla
The anagenphase is an
active phase of growth,it lasts
3 - 4 years
75 µm
ES
A B
OES
IES
p
50 µm
p
Anagen phase
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The trichogram determines: the Hair Formula
1%
84%
15%Anagen hairTelogen hairCatagen hair
The ratioAT
Anagen hair %Telogen hair %
4 : normal situation
< 3 : Pathological ratio
AT
=
=
AT
AT
=
The hair formula
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Classification according
to Hamilton
I II
III III Vertex
IV V
VI VII
Androgenic or seborrheic alopecia on man
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Androgenic alopecia is partly linked to the action of androgens on the papilla
Ludwig classification (on women)
Androgenic or seborrheic alopecia on woman
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• Inner factors- receptivity to male hormones- genetic tendency- psychic factors
• Nutritional factors- deficiencies • in proteins
• sulfur amino acids• in vitamins
- general deficiencies
• Seborrhea
Origin of androgenic alopecia
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TRICHOGEN® VEG LS 8960 is an unique trichogenic complex.It consists of a selection of synergistic components of botanical, biotechnological and synthetic origin.
Definition
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Sulfopeptidesof soy (glycine max)(MW ~ 15,000 Da)
Amino-acids: tyrosine, arginine, ornithine, citrulline
Aminosaccharideglucosamine
Regulators of cellular nutrition and growth.Supply in bioavailable sulfur,stimulation of protein biosynthesis
Precursors of proteins andmelanin pigments
GAG precursor for strengthening the extracellular papillary / peribulbar matrix
Composition and mode of action
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Vitamins of B group(PP, B5, biotin)
Zinc salt
Silicone and quaternium
Regulation of cellular nutrition
Seboregulation
Stimulation ofmicrocirculationAntimicrobial effects
Hair conditioner
Arctium Majus extract
Panax Ginseng extract
Composition and mode of action
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Anti-hair loss activity
40 male volunteerswith androgenetic alopecia (I to III) A/T ratio < 4
D0: sensorial and clinical appraisal - Trichogram
Treatment every two days 10 ml of hair lotion containing 10% TRICHOGEN® VEG LS 8960
D56 - D112 • Sensorial and clinical appraisal by the volunteers and a dermatologist
• Trichogram - Phototrichogram
Efficacy test (clinical test)
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Improvement of aesthetic qualities of hair and scalp Sensorial evaluation
Parameters
Shape, volumeSpringShineSilk
SeborrheaIrritation
Good42.545
52.542.542.537
112 days
Quite good1010
12.512.51213
Good52.552.542.55033
48.5
Improvement (% subjects) after:56 days
Quite good5
7.55
2.56
29.5
Efficacy test (clinical test) – Evaluation by the volunteers
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Decrease of hair loss
Combing Shampoo On the pillow
D0D56D112
Statistics:Student's t test(***) p ≤ 0.001(**) p ≤ 0.01(*) p ≤ 0.05(°) p ≤ 0.10(NS) = not significant
2
1.61.8
1.41.2
10.80.60.40.2
0
-7%(NS)
-24%(°)
-41%(***)
-45%(**)
-37%(***)
-38%(**)
Semi-quantitative appraisal by volunteers of hair loss
Efficacy test (clinical test) – Evaluation by the volunteers
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Improvement of hair growth
D56
D112
Lower hair loss
12.5%
10%
47.5%40%35%
40%
5%
10%
D56
D112
Faster hair growth
17.5%
12.5%
60%30%
50%
22.5%
7.5%
No effect Medium Good Quite good
Efficacy test (clinical test) – Evaluation by the volunteers
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The volunteers have observed:
- an improvement of the aesthetic qualities of hair and scalp,
- a lower hair loss,
- a faster hair growth
Efficacy test (clinical test) – Evaluation by the volunteers
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Improvement of the aesthetic qualities of hair and scalp
50
D56
D112
Dull hair
Lack of suppleness
“Fly away” effect
Volume
Irritated scalp
Oily hair
100%
Thin hair
Hair being hardto comb
50%0%of satisfied subjects
Splitted hair
Efficacy test (clinical test) – Evaluation by a dermatologist
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Anagen hair
Telogen hair
(X 40)
Visualization
Efficacy test (clinical test) – Trichogram evaluation
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Frontal Parietal Occipital 3 areas total0
2
4
6
8
10
12
14
16D0
D56
D112
+ 26% Alopecia threshold
+ 53%(*)
+ 138%(***)
+ 71%(***)
Anagen hair / Telogen hair ratio (A/T)
+ 106%(°)
+ 94%(***)
+ 163%(***)
+ 113%(***)
(NS)
Statistics:Student's t test(***) p ≤ 0.001(**) p ≤ 0.01(*) p ≤ 0.05(°) p ≤ 0.10(NS) = not sign.
1.4 1.7 2.8
9.8
6.4
12.4
76.3
2.6 3.57.46
Quantification
Efficacy test (clinical test) – Trichogram evaluation
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Same area after 4 months of treatment: new hairs appearcompared to before treatment, each one in anagen phase
Before treatment
1 mm1 mm
After treatment
Efficacy test (clinical test) – Phototrichogram evaluation
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Anti-hair loss activity
After 4 months of treatment, TRICHOGEN VEG LS 8690 clearly :
• Slows down hair loss.
• Improves hair regrowth : the growth is more important, and faster, on the parietal, occipital and frontal zones.
• Improves the aesthetic quality of hair and scalp.
• These effects are quantified, and visible on pictures and by the users.
Efficacy test (clinical test)
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• Strengthening effect on damaged human hair (traction test)
• Film-forming, bio-conditioning and repairing effect on dry hair (confocal microscopy)
• Conditioning effect
• Photo-protection of human hair, against UV-B induced damage (dansyl chloride)
• Stimulation of oxygen consumption (epithelial cells)
Other tests available
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ProtocolHair - Sodium Lauryl Sulfate at 15%
24 h after the last treatmentTraction test: after 1 treatment and after 5 successive treatments
Permanent wave Mercaptoacetate at 6% + H2O2 at 2% + rinsing
2 cycles of permanent have been doneOnce or 5 times
Without treatment
Placebo lotion
Lotion with 5%TRICHOGEN® LS 8960
3 ml of lotion on hair tress during 30 min + rinsing
Strengthening effect on damaged human hair (Traction test)
Efficacy tests
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+ 62% + 11% Post-yield slope
+ 23% + 10% Maximal force
+ 6% + 9% Force at 15%
After 1 treatment
% of increaseParameters After
5 treatments
The strengthening activity of TRICHOGEN® VEG LS 8960 at 5% on damaged hair isclearly demonstrated: the increase of hair mechanical parameters is significant even after only one application.
Strengthening effect on damaged human hair (Traction test)
Efficacy tests
Yieldregion
Post-yieldregion
F1
F15
F2
F3
Post-yield slope
StrainHookean region
Load
F1 =elasticity limitF2 =plasticity limitF3 =break point
Work to breakF15 =force at 15% of elongation
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Film-forming, bio-conditioning and repairing effect on dry hairConfocal microscopy
Hair was damaged by an acetone/ether blend and then treated withTRICHOGEN® VEG LS 8960 at 10%
TRICHOGEN® VEG LS 8960 at 10% has clearly improved the surface of hair, and shows a good hair conditioning / repairing effect.
Control hair Damaged hair with acetone/ether
Damaged hair treated with TRICHOGEN® VEG LS 8960
Efficacy tests
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Conditioning effect
TRICHOGEN® VEG LS 8960 at 10% has significantly improved combing parameters of hair. It has a good conditioning property
Maximal force (N)Work (Nmm)0
10
20
30
40
Before treatment
After treatment- 38.8%(*)
- 29.0%(*)
Mean value of the combing parameters ± SEM
Statistics:Average of 10 trials ± SEMpaired t test(*) significant/before treatment
0.8
0.6
0.4
0.2
0
1Traction
device cellTraction device
recorder
Comb
Hair tress
Quantitative evaluation of the conditioning effect of a lotion containing 10% TRICHOGEN® VEG LS 8960
Efficacy tests
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Photo-protection of human hair, against UV-B (dansyl chloride)Results
TRICHOGEN® VEG LS 8960 has shown a strong photo-protective effect of hair (increasing the fluorescence intensity by +28.8%)
Fluorescence intensity (Arbitrary units)
Statistics:Mann Whitney's U test(*) significant/correspondingcontrol
0
20
40
60
80
100
120
0
10
20
30
40 + 28.8%(*)
Hair lotionwith 10% of
TRICHOGENVEG LS 8960
No UV-B With UV-B*
Protection* UV-B 270 J/cm2
Untreatedcontrol
Untreatedcontrol ®
Hair lock
No UV UV
Reaction with dansyl chloride
Fluorescence quantification
Standard washing with SodiumLauryl Sulfate (= SLS) at 5%
Treatment with a hairlotion containing 10% of
TRICHOGEN® VEGLS 8960
Untreatedcontrol
hair
UV
Efficacy tests
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Stimulation of oxygen consumptionPolarographical measurements on homogenate of epithelial cells
Significant and dose-dependent increase of oxygen consumption by epithelial cells. TRICHOGEN® VEG LS 8960 clearly improves cell vitality.
0
20
40
60
80
100
Statistics:Average of 5 trials± SEMKruskal Wallis's test:SignificantA posteriori test:Mann Whitney U test(*) significantdifference incomparison to 0.5 %
Concentration of TRICHOGEN® VEG LS 8960 (%)
% increase of oxygen consumption
0.5 1 3 5
+ 22%
+ 51% (*)
+ 67% (*)+ 74% (*)
Efficacy tests
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Decrease of hair loss and stimulation of hair growthcellular metabolism and oxygenation are increased
Improvement of the aesthetic qualities of hairimprovement of hair softness, vitality, combability, suppleness, health
Improvement scalp conditionthe scalp is healthiersebaceous secretion is regulateddandruff, itchings are decreased
Cosmetodynamic properties
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• leave-on preparations: aqueous, hydro-alcoholic tonics
• rinse-off preparations: shampoos, conditioners
Cosmetic uses
• Anti-hair loss preparations
• Anti-age hair care
Formulations
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Aspect : limpid light yellow liquid with a characteristic odor
Dose of use : Anti-hair loss courses: 10%As complementary hair care: shampoos: 3 - 5%
Solubility : soluble in water, in hydroalcoholic solutes and insoluble in oils
INCI Name : Water (and) Panax Ginseng Root Extract (and) Arginine (and) Acetyl Tyrosine (and) Arctium Majus Root Extract (and) Hydrolyzed Soy Protein (and) Polyquaternium-11 (and) Dimethicone Copolyol (and) Calcium Pantothenate (and) Zinc Gluconate (and) Niacinamide (and) Ornithine HCl (and) Citrulline (and) Glucosamine HCl (and) Biotin.
Technical data
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TRICHOGEN® VEG LS 8960The effective active ingredient against hair loss