trichuris trichiura 2 para.pdf · 2020. 3. 19. · trichuris trichiura whip worm •geographical...
TRANSCRIPT
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Trichuris trichiura
Whip Worm
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• Geographical distribution -Parasite of warm climates • Morphology - 3 - 5 cm. Posterior 2/5th of the body is
thick (whip handle). Anterior 3/5th thin and is threaded into the mucosa of the large intestine. Posterior end of male is curved.
• Disease: Trichuriasis, trichocephaliasis • Habitat: Large intestine Disease • Infective stage: Embryonated egg • Diagnostic stage: Eggs • Transmission: By fecal pollution of soil. A person is
infected by ingestion of the infective eggs in food from contaminated fingers.
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Life Cycle:
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Pathogenesis and Clinical features
• Few worms – little damage
• Heavy infection- spread throughout the colon to the rectum causing Haemorrhages
• Muco-purulent stools, dysentery and rectal prolapse
• Mild infections are asymptomatic
• Children may get ‘Trichuris dysentery syndrome’ resulting in severe diarrhoea, malnutrition, growth retardation and impairment of cognitive functions
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Diagnosis
• Finding the characteristic eggs in stool by direct smear or by concentration methods
• Proctoscopy – in cases of dysentery, show numerous worms attach to the mucosa which is redden and ulcerated
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Treatment and prevention
• Mebendazole and Flubendazole
• Prevention: As Ascaris
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Strongyloides stercoralis
Dwarf Thread Worm
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Strongyloides stercoralis
• Disease: Strongyloidiasis
• Distribution - Worldwide but more common in warm climates. Major opportunistic infection among immunocompromised persons.
• Morphology - Male: The male measures1 mm in length with curved posterior end and carries two spicules
Female: The female measures 2.5 mm in length with straight posterior end.
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• Habitat: Small intestine
• Infective stage: Filariform larva
• Diagnostic stage: Larva (Rhabditiform larvae- Filariform larva)
• Transmission: Penetration of skin
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Life Cycle: Two life cycles –
Parasitic cycle ( if the external conditions are unfavorable) Free living cycle( if conditions are favorable )
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Clinical Features
Disease: Strongyloidiasis
Vast majority of infections in endemic areas are symptomless
Primary infection
• A pruritic erythematous eruption ‘Ground itch’ at the site of entry to larvae, last about 3 weeks
• Pneumonitis due to lung migration not common
Chronic uncomplicated strongyloidiasis
• Epigastric pain, anorexia, chronic diarrhoea due to mucosal damage, weight loss
• Skin rashes: Two types:
• Larva currens: Occur around the anus and anywhere on the trunk.
• larvae migrate under the skin :causes itchy rash which is not indurate & has a red flare at the edge
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Clinical Features
• Urticaria – Allergy to larval penetration in already sensitized patient. Occur in the buttocks with pruritus ani& around the waist. Last 1-2 days and can recurs at regular intervals
Severe complicated strongyloidiasis
• Severe disease with hyper-infection in persons with immunosupression.
• severe watery diarrhoea, often with malabsorption, hypoalbuminaemia causing Generalized oedema and Fever.
• Lungs hypereosinophilia, pneuminitis, diffuse crepitation, pulmonary abscess and gross respiratory failure.
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Diagnosis
• Microscopic identification of larvae (rhabditiform and occasionally filariform) in the stool or duodenal:
• Differentiate from hookworm 1st stage larvae: Ss 1st stage rhab larva has a short buccal capsule compared to that of Hw
• ELISA – to detect
parasite specific IgG
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Treatment and Prevention
• Thiabendazole
• Mebendazole and albendazole
• Pyrvinium pamoate
• Prevention like Ancylostomiasis