TUBERCULOSIS

Dr GHASSAN KAWAR

Mycobacteria

Acid fast ,aerobic bacilli

M TB obligate intracel parasite stains with Acid Fast so

named AFB

Fast in retaining of carbol fuchsin or fluorochrome dyes

after washing with acid or alcohol or both

Ziehl nielson stain

Cell wall contains complex lipids and glycolipids cord

factor produces granulomas

Multiply in phagocytic cells

Characteristic lesion granuloma with central caseation

and Langhans giant cells

TRANSMITION:PERSON TO PERSON BY INFECTIVE DROPLETS FROM RESPIRATORY SECRETIONS FROM AN ADULT WITH CAVITARY PULM TB COUGHING CROWDED ROOMS INGESTION LESS LIKELY

TUBERCULIN SKIN TEST ALTHOUGH NEGATIVE IN 5-20%

The biologically active material in the liquid medium

after growth of M TB named tuberculin after Koch

A purified protein derivative of tuberculin was made

(PPD)

Mantoux TEST tuberculin units injected intracutaneously