tuesday, march 6, 2012
DESCRIPTION
Tuesday, March 6, 2012. Open to entry- Protein Networks from yesterday Homework: Cell Transport retakes in tutorial- LAST DAY Quiz on Protein Pathways/Protein Structure- FRI Serotonin Pathway worksheet- due on Block Day. “Coat Color in Labrador Retrievers”. Cocoa. Midnight. - PowerPoint PPT PresentationTRANSCRIPT
Tuesday, March 6, 2012Open to entry- Protein Networks from yesterday
Homework:1) Cell Transport retakes in tutorial- LAST DAY2) Quiz on Protein Pathways/Protein Structure- FRI3) Serotonin Pathway worksheet- due on Block Day
“Coat Color in Labrador Retrievers”
Cocoa Midnight
Guiding Question:
“How does variation exist between organisms?”
Read: “Coat Colors in Labrador Retrievers” to help you answer this question.
Vocab to know for reading.• Pigment = A substance, such as chlorophyll or
melanin, that produces a characteristic color in plant or animal tissue.
• Skin and Hair pigments are produced in cells called melanocytes.
• Synthesize = to put together.
Labrador (dog) pigmentation
Tyrosine Dopaquinone
Brown pigment
Black pigment
Yellow pigmenttyrosinase
TRP-2
TRP-1Boxes = metabolitesArrows = enzymes that change the metabolites
What will be the dog’s coat color?
BLACK
Tyrosine Dopaquinone
Brown pigment
Black pigment
Yellow pigmenttyrosinase
TRP-2
TRP-1
What would happen if the enzyme TRP – 1 was missing?
Black pigment
What color is the dog’s coat? Brown
Boxes = metabolitesArrows = enzymes that change the metabolites
Tyrosine Dopaquinone
Brown pigment
Black pigment
Yellow pigmenttyrosinase
TRP-2
TRP-1
So what would happen if the enzymes TRP – 1 and TRP-2 were both missing?
Black pigment
What color is the dog’s coat? Yellow
Brown pigment
Boxes = metabolitesArrows = enzymes that change the metabolites
Entry 17-Protein Pathways Practice- 3/6/12Make an entry:
Entry 17: Protein Pathways Practice- 3/6/12See attached
Pigment Metabolic Network for the Imaginary Bioflower
Blue Flower Purple Flower
Where is the variation in these flowers? Blue and Purple Flowers (Color)
BioflowersA colorless starting molecule is converted by
enzyme X to blue pigment. Next, enzyme Y converts the blue pigment to purple pigment.
1a.Diagram of the pathway. (include a key)
Colorless Compound Blue Pigment Purple PigmentX Y
1b.Give an explanation for a blue flower.Enzyme Y not available or not working
“Roundbuds”
Roundbuds
In another type of wildflower, the roundbud, red pigment is synthesized from a white precursor by enzyme Q.
1. Draw the enzyme pathway for the roundbud.
It was believed that all roundbuds were red until a knowledgeable, observant teenager discovered a meadow full of white-flowered roundbuds.
2. Using your knowledge of the synthesis pathway for red pigment, give an explanation for the white roundbud variety.
White Precursor Red PigmentQ
2a. Draw Enzyme Pathway
In another type of wildflower, the roundbud, red pigment is synthesized from a white precursor by enzyme Q.
2b. It was believed that all roundbuds were red until a knowledgeable, observant teenager discovered a meadow full of white-flowered roundbuds.
Enzyme Q is not working- therefore no conversion to red pigment.
2b. Using your knowledge of the synthesis pathway for red pigment, give an explanation for the white roundbud variety.
White Precusor Red Pigment
Q
YELLOW PIGMENT IS CONVERTED BY ENZYME Z INTO BROWN PIGMENT
• YELLOW CAN ALSO BE CONVERTED BY ENZYME W INTO RED PIGMENT
• BROWN PIGMENT IS CONVERTED BY ENZYME X INTO BLACK PIGMENT
• BROWN CAN ALSO BE CONVERTED BY ENZYME Y INTO ORANGE
YELLOW PIGMENT
RED PIGMENT
BLACK PIGMENT
BROWN PIGMENT
ORANGEPIGMENT
Z W
XY
Chupacabra Coat Color
• Yellow= no Z or W• Brown= no X or Y, W• RED= no Z
#3. Fancy flowersa.
b. Red with white spotsc. No spots, red only
RED RED-WHITE SPOTS
RED-BLUE SPOTS
S T
A B C
D E F
12
34
5
#4 a. 1,2b. A,B, C, Dc. All except
Fd. 1, 3
Make an entry- Entry 18: Human Metabolic Networks- 3/6/12
Substrate Enzyme Product
Add to last question on back:How is a MAO inhibitor used to treat depression?