tumors of the kidney and urinary bladder hala kfoury,md
TRANSCRIPT
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TUMORS OF THE KIDNEY AND URINARY BLADDERHALA KFOURY,MD
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Objectives:
At the end of the lecture the students will be able to:
Recognize the benign tumors of the kidney.
Describe renal cell carcinoma and Wilm’s tumor.
Recognize transitional cell and squamous carcinoma of the urinary bladder.
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Benign tumors of the kidney:
1- adenoma2- angiomyolipoma
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Malignant RENAL NEOPLASMS
I. Neoplasms of the Renal Parenchyma
A. Renal cell carcinoma (renal adenocarcinoma; hypernephroma)
B. Nephroblastoma (Wilms's tumor)
C. Urothelial tumors
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RENAL NEOPLASMS
• Gross pathology and histology • Histogenesis • Clinical manifestations • Diagnosis: radiographic imaging • Treatment and prognosis • Pathophysiology
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Kidney with ischemic atrophy also bears very small subcapsular adenomas near to each pole.
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Histology of a subcapsular papillary adenoma shows tubules arranged in a papillary fashion.
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Human renal cell carcinoma
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Renal cell carcinoma
Renal cell carcinomais the most common primary renal tumor in adults and may be occult.
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Small clear cell renal cell carcinoma (hypernephroma, Grawitz tumor) is spreading into perirenal adipose tissue.
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Human renal clear cell carcinoma
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Typical lobulated, whorled, tan-colored cut surface of renal cell carcinoma.
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Invasion of the renal vein and inferior vena cava (arrow) by renal cell carcinoma.
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Papillary urothelial (transitional cell) carcinoma of renal pelvis. Note the exophytic, multifronded nature of the tumor.
Transitional cell carcinoma of the renal pelvis.
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Solid, bulging, fleshy tan-white, partially necrotic tumor has replaced much of the kidney and is encompassed by a thin rim of renal tissue..
Wilms’ tumor (nephroblastoma)
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This Wilms’ tumor appears whiter due to formalin fixation and has extended beyond the confines of the kidney
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Histology shows hypercellular areas comprising undifferentiated blastema, loose stroma with undifferentiated glomeruloid body.
Wilms’ tumor
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Urothelial (transitional cell) carcinoma in situ of the urinary bladder if untreated, up to 75% of cases go on to invasive cancer.
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Histology of carcinoma in situ (surface is to the right).
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Invasive urothelial carcinoma of the bladder is invading the muscle coat on the right side of the picture.
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Urothelial carcinoma of bladder.
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Advanced urothelial cancer of the bladder has spread posteriorly (arrow)to invade the uterus.
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Poorly differentiated urothelial carcinoma.