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TWiV 216: Processing viral RNA Virology 101

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Page 1: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

TWiV 216: Processing viral RNA

Virology 101

Page 2: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

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Page 3: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

m7GpppG

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Page 4: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

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Page 5: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

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Page 6: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

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Page 7: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

mRNA splicing discovered in adenovirus infected cells

Page 8: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

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Page 9: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Splicing of pre-mRNA

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Page 10: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

RNA-RNA interactions during splicing

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Page 11: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

RNA catalysis without protein

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Page 12: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Alternative splicing

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Page 13: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Alternative polyadenylation and splicing

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Page 14: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Control of RNA processing during retrovirus infection

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Page 15: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Alternative polyadenylation and splicing during adenovirus infection

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Page 16: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Viral proteins can regulate alternative splicing

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Page 17: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

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Page 18: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Rev protein regulates export of HIV mRNAs

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Page 19: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Mechanism of Rev protein mediated RNA export

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Page 20: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Retroviral mRNA export without Rev protein

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Page 21: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

For temporal regulation of viral gene expression, or inhibition of the production of cell mRNAs

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Page 22: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Editing of viral mRNAs

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Page 23: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

RNA editing produces mRNA for Ebola virus glycoprotein

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Page 24: TWiV 216: Processing viral RNA - Microbe · 2015-12-16 · Viral proteins that regulate RNA-processing reactions Functions Induces dephosphorylation of cellular SR proteins by protein

Editing of hepatitis delta satellite virus RNA

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