TYPE 2 TRANSLATIONAL RESEARCH

2009 GRANT PROGRAMS

UW Institute for Clinical and Translational Research (ICTR)Community-Academic Partnership Core (CAP)

UW Institute for Clinical and Translational Research

Overall Goal of ICTR

Create an environment that facilitates the transformation of research at the University into a continuum extending from investigation through discovery to translation into practice, thereby linking even the most basic research to practical and implemented improvements in human health.

ICTR 2009 Pilot Grant Programs

• Clinical and Type1 translational research– maximum $50,000 direct costs, 12 months

• Type 2 translational research– maximum $50,000 direct costs, 12 months

• NEW: Type 2 translational research community collaboration – maximum $200,000 direct costs, 24 months

The research continuum and role of “type 2”

“Realm” of Type 1 “Realm” of Type 2Basic bench

discovery/observation

Methods development

Pre-clinical animal studies

Efficacy Studies

Effectiveness research

Implementation research

Dissemination research

Policy research

Type 2 translational research solves problems in translating new and existing findings from efficacy studies to improvements in clinical practice and community health; often using a collaborative approach that engages community members, organizations and clinicians as partners in the research process.

How to define “community”?

• Community (as defined by NIH for PA-08-077, Community Participation in Research R01) "refers to target populations that may be defined by: geography; race; ethnicity; gender; sexual orientation; disability, illness, or other health condition; or to groups that have a common interest or cause, such as health or service agencies and organizations, health care or public health practitioners or providers, policy makers, or lay public groups with public health concerns.“

• "Community-based organizations“ (as defined by NIH for PA-08-077,

Community Participation in Research R01) refer to organizations that may be involved in the research process as members or representatives of the community. Possible community partners include, but are not limited to, Tribal governments and colleges, state or local governments, independent living centers, other educational institutions such as junior colleges, advocacy organizations, health delivery organizations (e.g., clinics, hospitals, and networks), health professional associations, non-governmental organizations, and Federally-qualified health centers."

Goal of T2 funding programs

T2 Pilot Program

To support the production of excellent, collaborative

research that addresses important health issues for the

State of Wisconsin and that will lead to further external,

peer-reviewed research projects.

T2 Community Collaboration Program

To support research partnerships that solve problems in translating

clinical and health-related scientific knowledge into meaningful changes in

practice, with the goal of improved health outcomes and/or reduced costs in the

State of Wisconsin. A community collaboration component is required.

Type 2 Grant Priority Areas

• Interdisciplinary research teams (across schools/colleges)

• New junior-senior investigator partnerships• UW-Madison/Marshfield collaborations• Targeted topic areas: pediatric sciences,

health disparities, HIV/AIDS • Novel methodologies• Collaboration with one of the Type 2 research

resource programs within ICTR-CAP

Type 2 Grant Logistics

T2 Pilot Grants

• 12-month project period

• Maximum of $50,000 in direct cost support

• Single PI per project; multiple co-Investigators

• Lead Applicants may submit more than one scientifically distinct proposal

• Current Pilot Grant awardees are not eligible to serve as a Lead Applicant

• Generation of preliminary data for future grant application

T2 Collaboration Grants

• 24-month project period

• Maximum of $200,000 in direct cost support

• Single PI per project; multiple co-Investigators

• Lead Applicants may submit more than one scientifically distinct proposal

• Research should be beyond pilot phase of investigation

• Community collaboration component is required

Lead Applicant (PI) Eligibility

• Have applied for membership to ICTR • Be employed by UW-Madison or Marshfield Clinic.

– Employment with UW-Madison can mean either sole employment or jointly-appointed faculty

– Collaboration with investigators from the UW System or UW Extension is encouraged.

• Have the following investigator status: – Assistant professor (tenure track, CHS, or clinical), assistant

scientist or K-award recipient – Associate/full professor (tenured, CHS, or clinical) or

associate/senior scientist who is proposing to significantly change the direction of his/her research to encompass Type 2 Translational Research activities

• Have well-developed plans for using the results of this study to pursue an externally-funded research program.

Type 2 Due Dates

• Mandatory Letter of Intent: March 2, 2009• For those who submitted a LOI for “community

collaboration” grant — notification of invitation to submit full proposal: March 11, 2009

• Type 2 Research Workshops: March 16th & 26th, 2009• Full Applications DUE: May 4, 2009• Peer Review: May 2009• ICTR-CAP Steering Committee Review: June 2009• External Committee Review: June 2009• ICTR Administrative Review: June 2009• Award Announcement: July 8, 2009

Evaluation Criteria

• Overall scientific excellence• Significance• Innovation• Community collaboration• Type 2 translational nature of research• Likelihood of leading to new peer-reviewed

funding• Extent to which the “special criteria” were met

2008 Type 2 ICTR Awards

Examples of 2008 Pilot Research Project Topics• Diabetes (prevention and assessment tools, 2 pediatric and 1

adult)• Remote Assessment of Traumatic Brain Injury• Primary Care Treatment of chronic diseases (chronic kidney

disease, depression, colon cancer)• Disease Screening and Process Improvement• Treating tobacco use, drug addiction and medication adherence

in partnership with community agencies • Obesity prevention program feasibility studies• Improving management systems in ICU and cardiac care units• Patient-centered and family-centered care assessments

Further questions?

See the FAQ document (copies available and on ICTR website)

Andrea Dearlove

608.262.7125

adearlove@wisc.edu