UCI Progress

MBIRN AHM

Progress

• Tool Development– FIPS and HID: Modifications to store derived data,

including morphometric measures from Freesurfer• Methods Development

– DTI: Submitted paper: • Setsu Wakana, Arvind Caprihan, Martina M. Panzenboeck, Michelle Perry,

James H. Fallon, Randy L. Gollub, Kegang Hua, Jiangyang Zhang, Hangyi Jiang, Prachi Dubey, Ari Blitz, Peter van Zijl, Susumu Mori. 2006. Tractography-based Quantitative Analyses of White Matter Anatomy: Tracking Protocol, Reproducibility and Tract-Specific Quantification of Cerebral Hemisphere

• Tool Use– Segmentations of MCI 1.5T multisite dataset: 50

cases done from two sites and initial analyses begun

•22 subjects: Site 17

•Clinical Scores (above): MMSE, ADAS, CDR, BDI, Sex, Age, Years of Education

•Segmentation of one-time MRIs via Freesurfer to yield segmentation statistics (below).

Tool Use: Morphometric analyses of MCI data

Coefficients

20089.004 4101.258 4.898 .000-94.184 17.073 -1.186 -5.517 .000

-776.605 251.268 -2.854 -3.091 .009-1177.876 310.849 -.914 -3.789 .002

741.066 233.020 1.557 3.180 .0071180.511 401.171 .903 2.943 .011815.291 277.403 2.060 2.939 .012622.303 280.638 .929 2.217 .045

(Constant)AgeMMSEtotalCDRtnoboxMMSETimeOrientationMMSEPlaceOrientationMMSEAttentionMMSERecall

Equation 1B Std. Error

Unstandardized CoefficientsBeta t Sig.

• Utilizing multivariate regression analysis employing weighted squares, currently we are working on evaluating the effects of depressive symptoms on various parts of the MCI brain.

• Additionally, in an effort at theoretical detection and developing tools to aid in the MCI to AD conversion discriminate, we are developing algorithms that predict the volumes of various brain regions and circuits for a more comprehensive glimpse at the MCI / AD realm.

Lft Hippocampal Volume=20067.004-94.153(AGE)-776.604(MMSEtotal)-1177.874(CDRtnbox)+ 741.069(MMSEtimeortn)+1180.511(MMSEplaceortn)+ 815.291(MMSEattn)+622.303(MMSErecl)

Tool Use: Morphometric analyses of MCI data

To test the latest versions of Freesurfer

MBIRN Facilitations: Longitudinal Analysis

Getting a new Siemens 1.5T after a GE 1.5T: Replicate longitudinal analyses from Han, et al. 2006

*Test software compatibility with an external site

*Ensure correct version of Freesurfer/system compatibility

*Obtain updated version with support for mgz image format

Han X, Jovicich J, Salat D, van der Kouwe A, Quinn B, Czanner S, Busa E, Pacheco J, Albert M, Killiany R, Maguire P, Rosas D, Makris N, Dale A, Dickerson B, Fischl B. Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer. Neuroimage. 2006 Aug 1;32(1):180-94. Epub 2006 May 2.

*Freesurfer reconstruction using Han’s longitudinal program

*Acquire Global mean thickness values and surface thickness measures for variability comparisons

??

6 subjects across 8 scans, 4 sessions, and 2 scanners

GE scanner conversion to Siemens scanner

Reconstruction of T1 images with Freesurfer v. 3.0.3

Determine between session and within session variability

Preliminary results - GE only

MBIRN Facilitations: Longitudinal Analysis

Mean global thickness across sessions

1.95

2

2.05

2.1

2.15

2.2

2.25

2.3

2.35

2.4

2.45

1 2 3 4 5 6

subject

mea

n gl

obal

thic

knes

s (m

m)

subject

MBIRN-related collaborations

• FBIRN Group Analysis of morphometry using Freesurfer

Fig.1 Fig.2

-Fig.1: ‘Average’ subject w/ regions of t-ratios, above set threshold of 1.71.

-Fig.2: Plot of correlation between subject class and cortical thickness.

-ROI contains 159 vertices

- Areas of the left hemisphere in which controls showed thicker grey matter measures than did schizophrenic patients, in a dataset of schizophrenic (n= 13) and control (n= 12) each from UCI. Analyzed using Freesurfer. Submitted to ICOSR 2007.

DTI Study

slicetimernifti_tool

Fips-mc-fsl

Fips-sm2-fsl

Fips-stc-fsl

Fips-b0c-fsl

aTaskData

B0_mag

DerivedDataA

DerivedDataD

DerivedDataC

DerivedDataB

avwmergeavwmaths++mcflirtnifti_tool

mri_fwhmip_32Rnifti_tool

bet preludefugue fugueflirt fuguenifti_tool

FIPS_MBTS_preprocs

B0_phase

SourceData

DerivedData

Transform

Sub-transform

Legend