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Unistra_Israel_Académie des Sciences, October 24th/25th 2018

Wed. October 24th (pp. 4-8): Parallel Symposia in Chemistry (ISIS)/Physics (IPCMS)/Maths (IRMA)/Biology (IGBMC) 9h00-17h00 : see pages with details 16h45-17h45 : Conférence grand public, Grand Amphithéâtre de Médecine, in french open to all, Joel Zlotogora (Hebrew U.) : ‘Dépistage de porteurs de maladies génétiques en population générale en Israel’ Thursd. October 25th (p. 2-3): Académies des Sciences Day – ISIS – Network Dynamics Committee: Jean-Louis Mandel, Bertrand Séraphin, Eric Westhof (Biology) Vladimir Torbeev (Chemistry) Benjamin Enriquez (Maths) Guido Pupillo and Giovanni Manfredi (Physics) Daniel Riveline (Coordinator) Locations of Symposia: ISIS (Chemistry and Académie des Sciences): 8 allée Gaspard Monge, Strasbourg IGBMC (Biology) 1 Rue Laurent Fries, Illkirch-Graffenstaden IRMA (Maths)7 Rue René Descartes, Strasbourg IPCMS (Physics) Bâtiment 69, 23 Rue du Loess, Strasbourg, Grand Amphithéâtre de Médecine : 4 Rue Kirschleger, Strasbourg

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Thursd. October 25th : Académies des Sciences Day – ISIS - Network Dynamics 9h-9h30 Introduction : Michel Deneken (Président de l’Université de Strasbourg), Pierre Corvol (Vice-Président de l’Académie des Sciences) 9h30-10h30 : 30 minutes talk (25 minutes + 5 minutes questions) Gula Yusupova (IGBMC) Ribosome structure-function inhibition by antibiotics Timor Baasov (Technion) Prokaryotic versus eukaryotic ribosomal selectivity as a tool for new drug discovery 10h30-11h00 : 4 Flashtalks of 3 minutes, and questions David Lalaouna (IBMC) - The double-life of transfer RNA Emma Schenckbecher (IBMC) - Thermodynamic study of antibiotics targeting the ribosome Nathaniel Yakobov (GMGM) - Characterizaton of MprF-like lipid aminoacylation factors in fungi Alexandre Smirnov (GMGM) - An ultraconserved biogenesis factor for bacterial type ribosomes 11h00-11h30 : Coffee 11h30-12h30 : 30 minutes talk (25 minutes + 5 minutes questions) Joseph Schacherer (GMGM) Population-scale genomic survey reveals the relevance of rare genetic variants on the phenotypic landscape J. Zlotogora (Hebrew U.) Genetic testing in Israel diverse population: from carrier screening for reproductive purposes to screening for early treatment 12h30-14h30 : Lunch 14h30-15h30 : 30 minutes talk (25 minutes + 5 minutes questions) Hannah Margalit (Hebrew U.) The multiple facets of post-transcriptional regulation by non-coding RNAs Pascale Romby (IBMC) RNA-dependent networks regulating virulence and adaptative responses in Staphylococcus aureus 15h30-16h00 : 4 Flashtalks 3’ and questions Sarah Becker (IGBMC) - You are what you experience: The impact of environment on cellular plasticity Alexandre Fréchard (IGBMC) - Cryo-EM structure of the transcriptional coactivator NuA4 Florent Waltz (IBMP) - The unique structure and composition of the plant mitochondrial ribosome Hughes Renault (IBMP) - Insights into plant adaptation to land garnered from the study of the phenylpropanoid pathway

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16h00-16h30 : Coffee 16h30-17h30 : 30 minutes talk (25 minutes + 5 minutes questions) Avraham Levy (Weizmann) Genetics with no sex— Somatic recombination in plants Laurence Drouard (IBMP) Macromolecular trafficking and translation in plants

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Chemistry : Wed. October 24th ISIS Auditorium 9:00 – 9:45 am Prof. Peter Faller (Institut de Chimie - UMR 7177, Université de Strasbourg) “Metal-binding to amyloid-beta peptides: coordination, reactivity, aggregation and biological implications” 9:55 – 10:40 am Prof. Yifat Miller (Department of Chemistry and the Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev) “Current challenges in investigating the effect of metals in amyloid aggregation” 10:50 – 11:35 am Prof. Galia Mayaan (Schulich Faculty of Chemistry, Technion - Israel Institute of Technology) “Bio-Inspired Applications of Metal-Binding Peptoids’’ 11:45 – 12:30 pm Dr. Vladimir Torbeev (Institut de Science et d'Ingénierie Supramoléculaires – UMR 7006, Université de Strasbourg) “Conformational dynamics of an intrinsically disordered protein controlled by α-methylation of amino acid residues” 14:00 – 14:45 pm Prof. Burkhard Bechinger (Institut de Chimie - UMR 7177, Université de Strasbourg) “Histidine-rich designer peptides with antimicrobial, transfection and transduction activities” 14:55 – 15:40 pm Prof. David Margulies (Department of Organic Chemistry, Weizmann Institute of Science) “Molecules that generate 'fingerprints': a new class of fluorescent probes for medical diagnosis and chemical biology” 15:50 – 16:35 pm Prof. Thomas Grutter (Laboratoire de Conception et Application de Molécules Bioactives - UMR 7199 CNRS / Université de Strasbourg) “Manipulating ion channel function with chemistry and light”

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Physics : Wed. October 24th; IPCMS, Cronenbourg campus

Israel-Strasbourg “Quantum dynamics” mini-symposium 09:15 – 09:30 Welcome introduction 09:30 – 10:00 Yael Roichman, “Statistical Mechanics of colloidal particles driven by light” 10:00 – 10:30 Cyriaque Genet, “Brownian motion and force detection strategies” 10:30– 11:00 Mini-talks (6 X 5min) + posters 11:00– 11:30 Coffee break + posters 11:30 – 12:00 Lazar Friedland, “Chirped-driven Bose-Einstein condensates” 12:00 – 12:30 Giovanni Manfredi, “Chirped excitation of the quantum gravitational

states of ultracold neutrons” 12:30 – 14:00 Lunch – CNRS restaurant + posters 14:00– 14:30 Mini-talks (6 X 5min) + posters 14:30 – 15:00 Igor Schapiro, “On the origin and the role of vibrational coherence in

the photoisomerization process - insight from computer simulations” 15:00 – 15:30 Jérémie Léonard, “Engineering the vibrational coherence of vision into

a synthetic molecular device” 15:30 – 16:00 Informal discussions + posters 16:00 Departure to the City Hall External invited speakers: Prof. Lazar Friedland (Racah Institute of Physics, The Hebrew University of Jerusalem, lazar@mail.huji.ac.il ) Prof. Yoel Roichman (Sackler faculty of Exact Sciences, School of Chemistry, Tel Aviv University, Tel Aviv roichman@post.tau.ac.il ) Dr. Igor Schapiro (The Hebrew University of Jerusalem, Jerusalem, Institute of Chemistry, <igor.schapiro@gmail.com>, igor.schapiro@mail.huji.ac.il )

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Mathematics: Wed. Oct. 24th; IRMA auditorium Organiser : Benjamin Enriquez (IRMA Strasbourg) Speakers :

F. Chapoton (IRMA Strasbourg) T. Delzant (IRMA Strasbourg) M. Entov (Dept. of Math, Technion, Haifa) S. Ladkani ((Dept. of Math, Haifa) E. Ophstein (IRMA Strasbourg) C. Perin (Einstein Institute of Math., Hebrew U. of Jerusalem)

08h45 Welcome

09h00 Frédéric Chapoton - IRMA

Derived categories from combinatorial data, I

10h00 Sefi Ladkani - Dept of Math., U. of Haifa

Derived categories from combinatorial data, II

11h15 Chloé Perin - Einstein Inst. of Math., HUJI, Jérusalem

Limit groups : applications in model theory and algebraic geometry, I

12h00 Lunch

13h45 Thomas Delzant - IRMA Limit groups : applications in model theory and algebraic geometry, II

15h00 Michael Entov - Dept. of Math., Technion, Haifa Poisson-bracket invariants in symplectic geometry and Hamiltonian dynamics : computations and applications, I

16h00 Emmanuel Opshtein - IRMA Poisson-bracket invariants in symplectic geometry and Hamiltonian dynamics : computations and applications, II

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Biology : Wed. Oct. 24th; IGBMC auditorium 8h45 : Welcome Introduction (C. Florentz, B. Séraphin, E. Westhof, J.L. Mandel, D. Riveline) 9h00-10h40 : 25 minutes talk (20 minutes + 5 minutes questions) Chair: Monica Pena-Luna 9h00 : Danny Ben-Zvi, The Hebrew University-Hadassah Medical School Weight loss independent effects of bariatric surgeries 9h25 : Romeo Ricci, Strasbourg Lysosomal pathways in type 2 diabetes 9h50 : Shulamit Levenberg, Technion Stem cells for engineering vascularized tissue grafts and flaps 10h15 : Julien Vermot, Strasbourg Mechanics and signaling in the developing cardiovascular system 10h40-11h15 : coffee break 11h15-11h45 : 8 Flashtalks of 3 minutes, Postdocs and PhD students Chair: Ayesha Dinshaw Eduljee 11h45-13h00 : 25 minutes talk (20 minutes + 5 minutes questions) Chair: Liubov Chechik 11h45 : Nicolas Charlet, Strasbourg How microsatellite repeats expansions located in the "non-coding" part of the genome can be pathogenic 12h10 : Yaron Shav-Tal, Bar-Ilan University Characterizing mRNA export at high resolution in individual nuclear pores in single cells 12h35 : Laszlo Tora, Strasbourg Visualization of endogenous transcription factor dynamics 13h-14h00 : Lunch 14h-14h50 : 25 minutes talk (20 minutes + 5 minutes questions) Chair: Robert Fagiewicz 14h00 : Joel Sussman, Weizmann Institute Recent breakthroughs in structure/function studies of acetylcholinesterase (AChE) 14h25 : Albert Weixlbaumer, Strasbourg Structural and biochemical studies on transcription elongation 14h50-16h05 : 25 minutes talk (20 minutes + 5 minutes questions) Chair: Pernelle Klein 14h50 : Ali Hamiche, Strasbourg Epigenetic mechanisms in Rett syndrome 15h15 : Eran Meshorer, The Hebrew University of Jerusalem Epigenetics: From pluripotent stem cells to ancient DNA 15h40 : Evi Soutoglou, Strasbourg Compartmentalization of DNA repair pathways

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Flashtalks: Arantxa AGOTE ARAN - Fragile X syndrome proteins control localization of nucleoporins Anna BONHOURE - Linear motif-mediated interactions allow E6 oncoprotein from HPV to highjack host proteins Liubov CHECHIK - The role of the chromatin organization in DNA double strand break repair in mouse embryonic stem cells Matej DURIK - Cellular fragmentation is a novel feature of senescent cells Nezih KARASU - Assessing promoter-enhancer interactions with Capture-HiC: how low can you go? Valentina Maria LIONELLO - Amphiphysin 2 (BIN1) modulation rescues MTM1 centronuclear myopathy and prevents focal adhesion defects Laia ORTIZ LOPEZ - In vivo actin dynamics during proepicardial formation in zebrafish. Roberto SILVA ROJAS - Reversal of the cellular phenotype of tubular aggregate myopathy (TAM) using a pharmacological approach

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