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UNITED STATES PATENT AND TRADEMARK OFFICE

BEFORE THE PATENT TRIAL AND APPEALS BOARD

AMNEAL PHARMACEUTICALS LLC Petitioner

v.

HOSPIRA, INC Patent Owner

Inter Partes Review No. IPR2016-01579 Patent 8,455,527

DECLARATION OF JAMES GORDON CAIN, MD, MBA, FAAP

Petition for Inter Partes Review of US 8,455,527 Amneal Pharmaceuticals LLC – Exhibit 1002

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TABLE OF CONTENTS I. INTRODUCTION ............................................................................................ 1

II. QUALIFICATIONS & BACKGROUND ........................................................ 2

III. INFORMATION CONSIDERED .................................................................... 3

IV. THE ‘527 PATENT .......................................................................................... 4

A. State of the Art ...................................................................................... 4

B. Scope of the ‘527 Patent ........................................................................ 6

V. CLAIM CONSTRUCTION ............................................................................ 7

A. A Person of Ordinary Skill in the Art (POSA) ..................................... 7

B. Broadest Reasonable Interpretation ...................................................... 7

C. Claim Terms of the ‘527 Patent ............................................................ 8

i. “Ready To Use” .......................................................................... 8

ii. “Dexmedetomidine” .................................................................10

VI. THE CLAIMED INVENTION IS WELL-KNOWN IN THE ART .............11

A. A POSA Would Have Been Motivated to Make the Invention of Claims 1-11 and 13 of the ‘527 by the 2010 Precedex Label in View of Palmgren .................................................. 11

i. Claim 1 ......................................................................................11

ii. Claims 2-5 .................................................................................17

iii. Claims 6-7 .................................................................................18

iv. Claim 8 ......................................................................................19

v. Claim 9 ......................................................................................19

Petition for Inter Partes Review of US 8,455,527 Amneal Pharmaceuticals LLC – Exhibit 1002 – Page i

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vi. Claim 10 ....................................................................................19

vii. Claim 11 ....................................................................................20

viii. Claim 13 ....................................................................................20

B. A POSA Would Have Been Motivated to Make the Invention of Claims 1-11 and 13 of the ‘527 by U.S. Patent No. 6,716,867 the 2010 Precedex Label and Palmgren ...................... 21

C. A POSA Would Have Been Motivated to Make the Invention of Claims 1-11 and 13 of the ‘527 by 2010 Precedex Label in view of Giorgi, Eichhorn, Palmgren, and the Lavoisier Documents ..................................................................... 26

VII. CONCLUDING STATEMENTS ..................................................................27

Petition for Inter Partes Review of US 8,455,527 Amneal Pharmaceuticals LLC – Exhibit 1002 – Page ii

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I. INTRODUCTION

I, James Gordon Cain, MD, MBA, FAAP, declare as follows:

1. I am over 18 years of age. I have personal knowledge of the facts

stated in this declaration and could testify competently to them if asked to do so.

2. In this proceeding before the U.S. Patent and Trademark Office

(“USPTO”), I have been retained by Amneal Pharmaceuticals LLC (“Amneal” or

“Petitioner”) as an independent expert consultant. Although I am receiving

compensation at my standard consulting rate for the time that I spend on this

proceeding, I have no other interest in its result. I also expect to be reimbursed for

reasonable expenses incurred in relation to my consulting. My compensation is

independent of the opinions rendered or the outcome of this proceeding.

3. I understand that this proceeding involves U.S. Patent No. 8,455,527

(“the ‘527 patent”), Ex. 1001, issued on June 4, 2013, and that the ‘527 patent

issued from U.S. Application 13/678,148 (Ex. 1054, “the ’148 application”) filed

on November 15, 2012. The ’148 application was a continuation of U.S.

Application No. 13/541,524 (Ex. 1048, “the ’524 application”), which was filed on

July 3, 2012, and issued as U.S. Patent No. 8,338,470 (Ex. 1053; “the ’470

patent”). The ’524 application, in turn, was a continuation of the U.S. Application

No. 13/343,672 (Ex. 1006), which was filed on January 4, 2012, and issued as U.S.

Patent No. 8,242,158 (Ex. 1047; “the ’158 patent”). Accordingly, the earliest

Petition for Inter Partes Review of US 8,455,527 Amneal Pharmaceuticals LLC – Exhibit 1002 – Page 1

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possible effective filing date of the ‘470 patent is January 4, 2012.

4. I have been asked by counsel for Amneal to explain the technical

subject matter of the ‘527 patent and its background. I have also been asked to

explain whether prior art discloses the compositions claimed in the ‘527 patent.

My opinions are set forth below.

II. QUALIFICATIONS & BACKGROUND

5. My qualifications and credentials are fully set forth in my curriculum

vitae, attached hereto as Exhibit A. I am an expert in the fields of clinical

anesthesia and sedation, with significant experience with ready-to-use medications.

In particular, I am knowledgeable about the use of dexmedetomidine for sedation

purposes. For the past 24 years, I have accumulated significant training and

experience in these and related fields.

6. In 1987, I received a B.S. in Biology from the University of Scranton.

In 1992, I received my M.D. from the School of Medicine at the University of

Pittsburgh. From 1992-1993, I attended Yale University as a Primary-Care

Internal Medicine intern. Through the Massachusetts General Hospital at Harvard

University, I completed my Anesthesiology Residency from 1993-1996 and

Critical Care Medicine Fellowship in 1997 as well as my Adult and Pediatric

Cardiac Anesthesiology Fellowship from 1995-1996 at the Massachusetts General

Hospital and Boston Children’s Hospital.


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7. Subsequent to my postgraduate work, I held the position of Instructor

at Harvard University in 1998 and as Assistant and Associate Professor at West

Virginia University from 1998-2005. From 2005 to the present, I have held the

position as Visiting Associate Professor at the University of Pittsburgh.

8. In addition to my academic appointments, I am currently the Director

of Perioperative Medical Services, Transplant Anesthesiology and Trauma

Anesthesiology as well as the Chief Charge Anesthesiologist at the Children’s

Hospital of Pittsburgh of UPMC. I have been employed as an anesthesiologist

and/or intensivist since 1996 in a number of additional roles, as set forth in my CV,

Ex. A.

9. Further, from 2000 to the present, I have gained a significant amount

of experience in the field of sedation by studying teaching the effect of

dexmedetomidine on patients. In particular, I am published in the field of

administration of dexmedetomidine and have given a multitude of invited lectures,

as enumerated in my CV, Ex. A.

10. I am not an attorney or patent agent and can offer no legal opinions.

My opinions here are based on my professional experience, expertise, and the

materials I have reviewed.

III. INFORMATION CONSIDERED

11. In forming my opinions, I have reviewed the ‘527 patent, its


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U.S. market, articles such as Venn et al., Anaesthesia 54:1136-1142 (1999), Ex.

1024, established that the prior art disclosed methods of sedating a patient while in

an intensive care unit by administering dexmedetomidine, or a pharmaceutically

acceptable salt thereof, to the patient.

16. Thereafter, in 2004, U.S. Patent No. 6,716,867 likewise disclosed

methods of sedating a patient. Ex. 1006, U.S. Pat. No. 6,716,867 (“the ‘867

patent”). The ‘867 patent was issued on April 6, 2004, and therefore constitutes

prior art under the relevant section of the patent code as I have been informed by

counsel.

17. The ‘867 patent specifically relates to a method of sedating a patient

while in the intensive care unit by administering dexmedetomidine or a

pharmaceutically acceptable salt thereof to the patient. Ex. 1006, abstract. The ‘867

patent describes the use of dexmedetomidine that is diluted in 0.9% sodium

chloride solution which is then ready for administration to patients. Id. at col. 7, ll.

60-65.

18. Administration of dexmedetomidine to a patient via parenteral

(including intravenous infusion and intramuscular, Ex. 1021, Dyck et al.,

Anesthesiology 78:813-820 (1993); Ex. 1022, Scheinin, et al., Anesthesiology

78:1065-1075 (1993)), transmucosal (including buccal and intranasal, Ex. 1023,

Yuen et al., Anesth. Analg. 105:374-80 (2007)) and oral routes was within the


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scope of the prior art. See also Ex. 1004 and Ex. 1005.

19. In the prior art, dexmedetomidine was provided as a concentrate that

directed the user to dilute prior to administration to a patient. See, e.g., Ex. 1007,

Sec. 2.4. Dexmedetomidine formulations for sedation were commercially available

in the U.S. as early as December 23, 1999, as PrecedexTM injection for intravenous

infusion following dilution (or alternatively “PrecedexTM Concentrate”).

20. The use of premix formulations of parental medications, particularly

those for use in an intensive care unit setting was also well known prior to the

filing date of the Patents-in-Suit. For example, Gerlach, Ex. 1020, proposes the use

of standardized drug preparations to improve medication safety in the ICU. See

also Giorgi, Ex. 1015 (most effective way to reduce microbial contamination in

ICU setting is use of ready-to-use solution). Thus, from at least these prior art

references, one of ordinary skill in the art would have been well aware of the

properties of dexmedetomidine and the benefits of ready to use medications.

B. Scope of the ‘527 Patent

21. Generally, the ‘527 patent disclosure and claims are directed relates to

premixed pharmaceutical compositions of dexmedetomidine and methods use of

the premixed compositions for sedation. Ex. 1001, col. 2, ll. 3 – 9, col. 10, ll. 1 –

25. The specification provides suitable containers including glass vials, ampoules,

syringes, and plastic flexible containers, such as polyvinyl chloride (PVC),


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VisIV™, polypropylene containers, and CR3 containers,. Id., col. 9, ll. 21–29. The

specification also provides numerous suitable concentrations for the premixed

concentrations, including the claimed concentration ranges of between about 0.005

to about 50 μg/mL. Id., col. 7, l. 44 – col. 8, l. 19.

V. CLAIM CONSTRUCTION

A. A Person of Ordinary Skill in the Art (POSA)

22. I have been informed that construction of the terms of a patent claim

is to be done from the point of view of a POSA at the time of the invention. For

purposes of defining a POSA, I have assumed that the time of the invention is the

date of filing of the ‘672 application, namely January 4, 2012.

23. In formulating my opinions, I have relied upon my review of the

references cited, my experience in the relevant art, and also considered the

viewpoint of a POSA. In my opinion, the POSA at the time of invention would

have held an advanced degree, such as a Ph.D. or MD in the field of drug

development and formulation, or in the alternative would have significant clinical

experience in anesthesia or sedation and would have familiarity with the use of

parenteral injection and/or familiarity with ready-to-use medications, as of January

4, 2012.

B. Broadest Reasonable Interpretation

24. I have been advised by counsel that in an inter partes review

proceeding before the USPTO, like this one, a patent claim term is to receive the


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“broadest reasonable interpretation” in light of the specification of the patent in

which it appears. I have also been advised that, at the same time, patent claim

terms are generally given their ordinary and customary meanings as would be

understood by a POSA.

25. I have also been advised by counsel that patent claims are to be

construed first in the context of the specification, including the plain meaning of

the claims, of the patent. The prosecution history of the patent should also be

considered to the extent that it provides clarification.

26. I have kept in mind these claim construction principles in the analysis

set forth below. In some cases, and where I have stated as such, my opinions have

also been informed by specific portions of the prosecution history of the ‘527

patent.

C. Claim Terms of the ‘527 Patent

i. “Ready To Use”

27. The ‘527 patent discloses an embodiment of the claimed

pharmaceutical composition as being a “ready to use” liquid pharmaceutical

composition. I have set forth my understanding, as a person of ordinary skill in the

art, of what the term “ready to use” means below.1

1 The dependent claims, in my opinion, do not introduce any terms that require

construction.


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28. The claims of the ‘527 patent describe the claimed liquid

pharmaceutical composition as being “ready to use” for parenteral administration.

For example, independent claim 1 of the ‘527 patent reads:

A method for providing sedation to a patient in need thereof, the

method comprising administering to the patient an effective amount

of a composition, wherein the composition comprises

dexmedetomidine or a pharmaceutically acceptable salt thereof at a

concentration of about 0.005 to about 50 μg/mL, wherein the

composition is a ready to use liquid pharmaceutical composition for

parenteral administration to the patient disposed within a sealed glass

container.

Ex. 1001, col. 26, ll. 25-34.

29. Also, the specification of the ‘527 patent discloses that the

formulation of dexmedetomidine can be “ready to use.” In particular, the

specification of the ’527 patent states:

[i]n certain embodiments, the compositions of the present invention

can be formulated as ‘ready to use’ compositions which refer to

premixed compositions that are suitable for administration to a

patient without dilution. For example, in certain embodiments, the

compositions of the present invention are ‘ready to use’ upon


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removing the compositions from a sealed container or vessel.

Ex. 1001, at col. 3, ll. 59-65 (emphasis added).

30. Additionally, the term “ready to use” is a well-known term of art in

the medical and pharmaceutical industry. See, e.g., Ex. 1044, “Injectable

medicines,” WHO Collaborating Centre for Pharmaceutical Pricing and

Reimbursement Policies, http://whocc.goeg.at/Glossary/PreferredTerms (last

visited August 9, 2016). It is my opinion that one of skill in the art would

understand the term “ready to use” to mean “requiring no further dilution or

reconstitution before transfer to an administration device.” Id.

31. Based on these descriptions, and my understanding of how this term is

used by persons of ordinary skill in the art, it is my opinion that the broadest

reasonable interpretation of “ready to use” must include a liquid pharmaceutical

composition that requires no further dilution or reconstitution before administration

to a patient.

ii. “Dexmedetomidine”

32. The ‘527 patent discloses an embodiment of the claimed

pharmaceutical composition as comprising dexmedetomidine. The specification

further defines “dexmedetomidine” as “(S)-4-[1-(2,3-dimethylphenyl) ethyl]-1H-

imidazole,” and provides the following chemical formula:


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Ex. 1001, col. 3, ll. 24-50.

33. The specification of the ‘527 patent defines dexmedetomidine as a

“substantially pure, optically active dextrorotary stereoisomer of medetomidine, as

the free base or pharmaceutically acceptable salt.” Ex. 1001, col. 3, ll. 24-29.

34. Therefore, it is my opinion that the broadest reasonable interpretation

of “dexmedetomidine” means “substantially pure, optically active dextrorotary

stereoisomer of medetomidine, as the free base or pharmaceutically acceptable

salt.” Id.

VI. THE CLAIMED INVENTION IS WELL-KNOWN IN THE ART

A. A POSA Would Have Been Motivated to Make the Invention of Claims 1-11 and 13 of the ‘527 by the 2010 Precedex Label in View of Palmgren

35. I have been asked to opine whether the 2010 Precedex Label would

have motivated a POSA to make the invention of claims 1-11 and 13 of the ‘527

patent in view of Palmgren.

i. Claim 1

36. It is my opinion that a POSA would be motivated by the prior art to

provide sedation to a patient in need thereof by administering to the patient an


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effective amount of a composition, wherein the composition comprises

dexmedetomidine or a pharmaceutically acceptable salt thereof at a concentration

of about 0.005 to about 50 μg/mL, and wherein the composition is a ready to use

liquid pharmaceutical composition for parenteral administration to the patient

disposed within a sealed glass container.

37. First, the method of providing sedation to a patient in need by

administering an effective amount dexmedetomidine parenterally was well known

to a POSA at the time of invention.

38. For example, the 2010 Precedex Label disclosed a method of

providing “sedation of initially intubated and mechanically ventilated patients

during treatment in an intensive care setting.” Ex. 1007, Sec 1.1. The

administration of dexmedetomidine has been a routine method for providing

sedation to a patient since 1999. Ex. 1024.

39. Further, it is my opinion that in view of the routine nature of medical

practice to choose the appropriate amount and concentration of drug to be

administered under particular set of circumstances, it would have been obvious for

a POSA to prepare a ready to use solution of dexmedetomidine hydrochloride at a

concentration of about 0.005 to about 50 μg/mL.

40. For example, the 2010 Precedex Label directed a POSA to prepare a 4

μg/mL solution of Precedex for parenteral administration via intravenous infusion


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by diluting 2 mL of Precedex in 48 mL of 0.9% sodium chloride injection to a total

of 50 mL.

41. Additionally, in my experience, dosages in “ready to use” form are

commonly used and have been for a number of decades.

42. With respect to the concept of “ready to use,” I understand that during

prosecution of the related ‘524 application, Applicants submitted arguments to

overcome an obviousness rejection over the Precedex Draft Label. Ex. 1049,

Office Action Response, mailed Sept. 17, 2012, U.S. Application No. 13/541,524.

43. Specifically, the applicants argued that the Precedex Label failed to

suggest or describe a premixture composition comprising about 0.005 to about 50

μg/mL of dexmedetomidine disposed within a sealed glass container that is ready

to use without dilution. Id. at p. 5.

44. The applicants argued that “upon withdrawing the claimed

composition from a sealed glass container, an artisan of ordinary skill can

administer the composition directly to a subject” whereas the Precedex Label

composition would be “not suitable for administering to a patient upon

withdrawing the composition from a sealed container.” Id. at p. 6.

45. In my opinion, the undiluted Precedex® solution disclosed in the 2010

Label is ready to use for parenteral administration to a patient in some

circumstances.


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46. Based on my experience, dexmedetomidine is routinely administered

parentally (primarily intramuscularly) and transmucosally to patients in the

undiluted concentration of 100 mcg/mL directly from the vial as described in the

2010 Precedex Label and demonstrates successful results. For example, undiluted

intranasal administration has become a prime method of sedation for pediatric

patients at the Children’s Hospital of Pittsburgh.

47. In fact, as part of my usual practice, I, and our sedation team in

general, administer PrecedexTM to patients at the provided, undiluted concentration

of 100 μg/mL, directly from the glass vial. In my opinion, the undiluted

concentration of PrecedexTM, without dilution, is ready to use, just as effective as

the diluted formulation and the preferred concentration for intramuscular and

transmucosal administration. This 100 mcg/cc concentration of ready to use

dexmedetomidine is typically used for preoperative premedication and procedural

sedation either as a solo agent or an adjunct with medications such as midazolam

and ketamine. See also Ex. 1039, G. DiSilvio, M. Jacoby, D. Weiner, A.

Broussard, P. Callahan, and J. Cain, “Intranasal Dexmedetomidine & Midazolam:

A Novel Sedation Technique for Infant PFT,” Society for Pediatric Anesthesia,

Phoenix, Arizona (March 2015).

48. Furthermore, and in contrast to some medications which require

central venous administration unless diluted (e.g. dopamine, potassium and


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parenteral nutrition), insofar as I can ascertain there is no documented harm in

administration of intravenous dexmedetomidine at 100mcg/ml other than the

inconvenience of its relatively small volume.

49. Dexmedetomidine is also routinely administered in the diluted

concentration of 4 mcg/mL by following the dilution instructions set forth by the

1999 Precedex package insert and the 2010 Precedex Label. As noted above, the

2010 Precedex Label directed a POSA to prepare a 4 μg/mL solution of Precedex

for parenteral administration via intravenous infusion by diluting 2 mL of Precedex

in 48 mL of 0.9% sodium chloride injection to a total of 50 mL.

50. Differential dilution is routine and necessary in medical practice in

order to tailor the appropriate amount and concentration of drug to be administered

under particular sets of circumstances, such as for pediatric patients, to maintain

osmolality, to avoid phlebitis and/or to avoid fluid overload. See Ex. 1040, Neu et

al., Crit. Care Med. 10:610-12 (1982); Ex. 1041, Potts et al., Pediatrics 113:59-62

(2004); Ex. 1042, Merry et al., Pediatric Anesthesia 21:743-753 (2011); Ex. 1043,

Rodriguez-Gonzalez et al., J. Am. Med. Info. Assoc. 1:72-78 (2012).

Additionally, many locations, including Children’s Hospital of Pittsburgh, have

discontinued nearly all ICU bedside differential dilutional preparations and moved

them to sterile preparation by pharmacy. See Ex. 1038.

51. In fact, prior to January 4, 2012, I asked our pharmacy to prepare 10


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mL premixed syringes of dexmedetomidine at a diluted concentration of 4 mcg/mL

for use as an anesthetic. Ex. 1035.

52. Since 2005 our pharmacy has been preparing these syringes in a

sterile environment. They determined that per their review of literature and

customary treatment of other medications they routinely dilute, that a shelf life of 7

days was acceptable. I am unaware of any adverse events attributable to this

practice since it began.

53. Given the routine use and general acceptance of “ready to use” in the

industry, and as shown in the prior art, a POSA would have been motivated to

create an embodiment that falls within the scope of claims 1-11 and 13 based on

available prior art.

54. Finally, in the Declaration of Dr. Yaman, which I have reviewed, he

states that as evidenced by Palmgren, it was well known in the art that certain

drugs, including medetomidine, interact with plastics found in infusion bags and

intravenous tubing, which can lead to drug loss in treatment failure, and thus a

POSA would have selected glass as the preferred container. Ex. 1017, p. 370. Ex.

1003, ¶52.

55. Therefore, it is my opinion that a POSA would have been motivated

to parenterally administer a ready-to-use solution of dexmedetomidine

hydrochloride at a concentration of 4 μg/mL (or any other appropriate


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concentration) that is disposed within a sealed glass container.

ii. Claims 2-5

56. I understand that Claims 2-5 each depend from claim 1 and further

recite narrower concentration ranges of the dexmedetomidine or pharmaceutically

acceptable salt thereof. Claim 2 recites that “the dexmedetomidine or

pharmaceutically acceptable salt thereof is at a concentration of about 0.05 to about

15 μg/mL;” claim 3 recites that “the dexmedetomidine or pharmaceutically

acceptable salt thereof is at a concentration of about 0.5 to about 10 μg/mL;” and

claim 4 recites that “the dexmedetomidine or pharmaceutically acceptable salt

thereof is at a concentration of about 1 to about 7 μg/mL;” and claim 5 recites that

“the dexmedetomidine or pharmaceutically acceptable salt thereof is at a

concentration of about 4 μg/mL.”

57. As I noted above, the Precedex 2010 Label directed a POSA to

prepare a 4 mcg/mL [i.e., 4 μg/mL]) solution of Precedex® for administration to

patients, a concentration encompassed by the ranges recited in claims 2 -5 of

the ’527 patent. (Ex. 1007, Sec. 2.4.)

58. And because dilution is routine and necessary in medical practice to

tailor the appropriate amount and concentration of drug to be administered under

particular sets of circumstances, it would have been obvious to a POSA to prepare

a ready-to-use solution of dexmedetomidine hydrochloride at a concentration of 4


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µg/mL, for parenteral administration to a patient, e.g., via intravenous infusion,

because the 2010 Precedex Label directed a POSA to do so. Ex. 1007, Sec. 11, ll.

457-458.

59. Accordingly, the 2010 Precedex Label disclosed all of the added

features of claims 2-5.

iii. Claims 6-7

60. I understand that claim 6 depends from claim 1 and recites that “the

composition is administered perioperatively.” Claim 7 depends from claim 6 and

recites that “the composition is administered before or after surgery.”

61. The Precedex 2010 Label discloses in Section 1.2 that “Precedex is

indicated for sedation of non-intubated patients prior to and/or during surgical and

other procedures.” Exhibit 1007, Sec. 1.2 (emphasis added).

62. Based on my experience, a POSA would understand that perioperative

administration recited in claim 6 comprises administering Precedex before, during,

or after surgery. Ex. 1061.

63. A POSA would also understand that administration can occur to a

patient in an intensive care unit. Ex. 1024; Ex. 1061.

64. Accordingly, the 2010 Precedex Label also discloses all of the added

features of claim 6 and claim 7. Thus, the added limitations do not overcome the

obviousness established for claim 1 over the Precedex label and Palmgren.


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iv. Claim 8

65. I understand that claim 8 depends from claim 1, and recites that “the

composition is administered to the patient in an intensive care unit.”

66. In numerous places, the 2010 Precedex Label discloses that Precedex

is indicated for treatment “in an intensive care setting.” See, e.g., Ex. 1007, 1.1, ll.

144-149.


features of claim 8, and the added limitations do not overcome the obviousness

established for claim 1 over the Precedex label and Palmgren.

v. Claim 9

68. I understand that claim 9 depends from claim 1, and recites that “the

patient is non-ventilated or intubated.”

69. The Precedex 2010 Label discloses in Section 1.1 that “Precedex has

been continuously infused in mechanically ventilated patients prior to extubation,

during extubation, and postextubation.” Ex. 1007, 1.1, ll. 148,149.


features of claim 9.

vi. Claim 10


patient is critically ill.”

72. The 2010 Precedex Label discloses that Precedex is used in “an


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intensive care setting.” Regardless of the meaning of “critically ill”, a person

having ordinary skill in the art would understand that an individual that is

“critically ill” encompasses the type of illness that may be treated in an intensive

care setting.

73. Further, it was known in the art at the time of filing that

“[d]exmedetomidine is a sedative with a unique mechanism of action that became

available in the United States in 1999 for sedation of critically ill patients.” Ex.

1020, Gerlach at 2 (emphasis added).

74. Accordingly, the 2010 Precedex Label, by itself or in combination

with Gerlach, also discloses all of the added features of claim 10.

vii. Claim 11


composition is administered by intravenous infusion.”

76. The 2010 Precedex Label discloses in multiple sections, including

Section 17, that “Precedex is indicated for short-term intravenous sedation.”

Accordingly, the 2010 Precedex Label also discloses all of the added features of

claim 11, and the added limitations do not overcome the obviousness established

for claim 1 over the Precedex label and Palmgren.

viii. Claim 13



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composition is administered as an adjunct to an anesthetic.”

78. As noted in Section 2.3 of the 2010 Precedex 2010 Label, Precedex

may be “co-administered” with “other concomitant anesthetics.” Similarly, the

Precedex 2009 Dosing Guidelines disclose on page 14 that “Coadministration of

anesthetics, sedatives, hypnotics and opioids with Precedex can enhance the

pharmacodynamic effects of these agents and a decrease in the dosage of Precedex

or the concomitant medication may be required when initiating Precedex.” Ex.

1063; eee also Ex. 1062.

79. Accordingly, the 2010 Precedex Label, alone or in combination with

the 2009 Precedex Dosing Guidelines, also discloses all of the added features of

claim 13.

80. For these reasons, it is my opinion that the 2010 Precedex Label,

viewed through the knowledge of a POSA, would have led that POSA to

administer the pharmaceutical composition claimed in claims 1-11 and 13 of the

‘527 patent.

B. A POSA Would Have Been Motivated to Make the Invention of Claims 1-11 and 13 of the ‘527 by U.S. Patent No. 6,716,867 the 2010 Precedex Label and Palmgren

81. I have been asked to opine whether U.S. Patent No. 6,716,867 would


patent in view of 2010 Precedex Label and Palmgren.


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82. For the reasons set forth below, it is my opinion that a POSA would

be motivated by the prior art to provide sedation to a patient in need thereof by

administering to the patient an effective amount of a composition, wherein the

composition comprises dexmedetomidine or a pharmaceutically acceptable salt

thereof at a concentration of about 0.005 to about 50 μg/mL, and wherein the

composition is a ready to use liquid pharmaceutical composition for parenteral

administration to the patient disposed within a sealed glass container.

83. With respect to the teachings of the 2010 Precedex Label and

Palmgren, I incorporate my opinions set forth above.

84. With respect to claim 1, a POSA would understand that the ’867

patent disclosed “a method of sedating a patient while in the ICU that comprises

administering dexmedetomidine or a pharmaceutically acceptable salt thereof.” Ex.

1006, col. 3, ll. 38-42.

85. The ’867 patent further disclosed “use of dexmedetomidine or a

pharmaceutically acceptable salt thereof in intensive care unit (ICU) sedation” and

also “use of dexmedetomidine or a pharmaceutical salt thereof in the manufacture

of a medicament for intensive care unit sedation.” Id., col. 1, ll. 12-14 and 28-31.

86. Additionally, a POSA would appreciate that the ’867 patent taught

intravenous (a form of parenteral) administration of dexmedetomidine or

pharmaceutically acceptable salt thereof. Id., col. 5, l. 7. Both the ’867 patent and


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the 2010 Precedex Label disclosed or otherwise taught parenteral administration of

dexmedetomidine via intravenous infusion.

87. Further, unlike the 2010 Precedex Label, which disclosed the

undiluted dexmedetomidine hydrochloride solution provided in a glass vial at a

concentration of 200 μg/2 mL (100 μg/mL), (Ex. 1007, Sec. 3, ll, 207-208), the

Examples within the ’867 patent disclosed administering dexmedetomidine or its

salt in liquid form (“[d]exmedetomidine was used in the form of an HCl salt (100

μg/mL base), in 0.9% sodium chloride solution”) as an intravenous infusion. Ex.

1006, Example 1, col. 5, ll. 53-58.

88. A POSA would appreciate that the dose ranges disclosed within

the ’867 patent further evidence that the ’867 patent disclosed the ready-to-use

concentration of 4 µg/mL dexmedetomidine. Specifically, the ’867 patent disclosed

intravenous administration of a dosage range from “about 0.2-2 μg/kg, preferably

about 0.5-2 μg/kg, more preferably 1.0 μg/kg,” for a bolus dose, and from “about

0.1-2.0 μg/kg/h, preferably about 0.2-0.7 μg/kg/h, more preferably about 0.4-0.7

μg/kg/h” for a maintenance dose. Ex. 1006, col. 5, ll. 21-28.

89. Further, a POSA would understand that the ‘867 patent disclosed

dosage ranges that are ready to administer to a patient via intravenous infusion

without dilution, particularly in light of the specific instruction provided by the

2010 Precedex Label. Therefore, a POSA would be motivated to prepare and


24

administer ready to use formulation of dexmeditomidine as recited in claim 1 of

the ‘527 patent based on the disclosure of the ‘867 patent in view of the 2010.

90. Finally, a POSA would also appreciate that the ready to use

dexmedetomidine or pharmaceutically acceptable salt thereof disclosed in the ’867

patent is also administered intravenously (a form of parenteral administration).

(Ex. 1006, col. 5, line 7).

91. Accordingly, POSA reading the ‘867 patent (Ex. 1006) would have

been motivated to combine its teachings with those of the 2010 Precedex Label

(Ex. 1007), thereby arriving at a method of parenterally administering a ready to

use liquid dexmedetomidine pharmaceutical composition to a patient.

92. With respect to claims 2-5, a POSA would recognize that the ’867

patent disclosed a range of concentrations of ready-to-use dexmedetomidine, and

thus the ranges recited in dependent claims 2-5 of the ‘527 patent add nothing to

overcome the obviousness of claim 1 over the ‘867 patent (Ex. 2006), along or in

view of the 2010 Precedex Label (Ex. 2007). Specifically, the ’867 patent

disclosed intravenous administration of a dosage range from “about 0.2-2 μg/kg,

preferably about 0.5-2 μg/kg, more preferably 1.0 μg/kg,” for a bolus dose, and

from “about 0.1-2.0 μg/kg/h, preferably about 0.2-0.7 μg/kg/h, more preferably

about 0.4-0.7 μg/kg/h” for a maintenance dose. Ex. 1003, ¶72; Ex. 1006, col. 5, ll.

21-28.


25

93. With respect to claims 6-7, the ’867 patent discloses the use of

dexmedetomidine both before and after surgery. See, e.g., Ex. 1006, Examples. In

my opinion, a POSA would understand that perioperative administration, as recited

in claim 6, comprises administering Precedex before, during, or after surgery. In at

least Example 7 of the ‘867 patent, perioperative administration is disclosed,

particularly since the patient was returned to surgery following administration of

dexmedetomidine. Ex. 1006, col. 10, ll. 33-60.

94. With respect to claim 8, a POSA would appreciate that the ‘867 Patent

“relates to the use of dexmedetomidine or a pharmaceutically acceptable salt

thereof in intensive care unit (ICU) sedation” and also “relates to the use of

dexmedetomidine or a pharmaceutical salt thereof in the manufacture of a

medicament for intensive care unit sedation.” Ex. 1006, col. 1, ll. 12-14 and 28-31.

95. With respect to claims 9-10, a POSA would understand that based on

the ‘867 disclosure, dexmedetomidine may be used “for non-ventilated, critically

ill patients.” Ex. 1006, col. 4, ll. 63-64. Specifically, the Examples of the ’867

patent disclose patients to whom dexmedetomidine were administered who were

mechanically ventilated or intubated. (See, e.g., Ex. 1006, Example 1, col. 5, ll. 49-

53; Example 2, col. 6, ll. 45-48. Also, the ‘867 Patent discloses that

dexmedetomidine may be used “for non-ventilated, critically ill patients.” Ex.

1006, col. 4, ll. 63-64. Regardless of the meaning of “critically ill”, a person


26

having ordinary skill in the art would understand that it encompasses the type of

illness that may be treated in an intensive care setting.

96. With respect to claim 11, the ‘867 patent discloses intravenous

administration of dexmedetomidine or pharmaceutically acceptable salt. Ex. 1006,

see, e.g., col. 5, line 7.

97. With respect to claim 13, a POSA would understand that the’867

patent discloses the administration of dexmedetomidine as an adjunct to an

anesthetic, such as propofol. Ex. 1006, see, e.g., Example 3, case 8, col. 11, ll. 6-

10: “[a] dexmedetomidine loading dose (0.4 μg/kg/h) was administered with

propofol”. A POSA would recognize that propofol, as identified in the ’867

patent, is an anesthetic. Ex. 1006, col. 1, ln. 51).

98. For these reasons, it is my opinion that the ‘867 patent, viewed

through the knowledge of the 2010 Precedex Label would have led that POSA to

administer the pharmaceutical composition claimed in claims 1-11 and 13 of the

‘527 patent.

C. A POSA Would Have Been Motivated to Make the Invention of Claims 1-11 and 13 of the ‘527 by 2010 Precedex Label in view of Giorgi, Eichhorn, Palmgren, and the Lavoisier Documents

99. I have been asked to opine whether the 2010 Precedex Label would


patent in view of Giorgi, Eichhorn, Palmgren, and the Lavoisier Documents.


27

100. In my opinion, a POSA would have had a reasonable expectation of

success combining each reference because together they yield nothing more than

predictable and expected results, namely, a method of parenterally administering to

patients a solution of Precedex in a glass container at a suitable concentration.

101. With respect to the teachings of the 2010 Precedex Label and

Palmgren, I incorporate my opinions set forth above.

102. Furthermore, it is my opinion, based on the Declaration of Dr. Yaman,

which I have reviewed, that the Giorgi, Eichhorn, and the Levoisier Documents.

establish that one of skill in the art would have been motivated to administer ready

to use, or premixed, diluted solutions of Precedex at the 4 mcg/mL concentration

from glass containers as instructed in the 2010 Precedex Label. Ex. 1003, ¶¶76-80.

These references establish that, at the time of filing, those of skill in the art

recognized, and indeed had been advocating for, additional standardization of drug

administration methods. Ex. 1003, ¶¶76-80. Thus, a POSA would have been

motivated to parenterally administer a ready to use, liquid pharmaceutical

composition as disclosed in claims 1-11, and 13, in view of this prior art. Ex. 1003,

¶¶76-80.

VII. CONCLUDING STATEMENTS

103. In signing this declaration, I understand that the declaration will be

filed as evidence in a contested case before the Patent Trial and Appeal Board of


EXHIBIT A

Curriculum Vitae – James Gordon Cain


CURRICULUM VITAE

James Gordon Cain, MD, MBA, FAAP

1

June 2016 James Gordon Cain, MD, MBA, FAAP

Director, Perioperative Medical Services, Children’s Hospital of Pittsburgh of UPMC Director, Transplant Anesthesiology, Children’s Hospital of Pittsburgh of UPMC

Director, Trauma Anesthesiology, Children’s Hospital of Pittsburgh of UPMC Visiting Associate Professor, Department of Anesthesiology, University of Pittsburgh

Past President, International Trauma Anesthesiology and Critical Care Society Past President, West Virginia Society of Anesthesiologists

BIOGRAPHICAL

Name Birth Date James Gordon Cain, MD, MBA, FAA P February 25 Home Address Birth Place 107 Sherborne Drive Towanda, Pennsylvania McMurray, Pennsylvania 15317 Cell Phone Citizenship 724.506.3141 United States of America Business Address E-mail Department of Anesthesiology Hospital: [email protected] Children’s Hospital of Pittsburgh of UPMC University: [email protected] 4401 Penn Avenue Personal: [email protected] Pittsburgh, Pennsylvania 15224 Business Phone Business Fax 412.692.5260 412.692.8685

EDUCATION AND TRAINING POSTGRADUATE 1997 Massachusetts General Hospital Critical Care Medicine Fellowship

Harvard University William Hurford, MD


CURRICULUM VITAE


2

Boston, Massachusetts 1995-1996 Massachusetts General Hospital Adult and Pediatric Cardiac

Boston Children’s Hospital Anesthesiology Fellowship Harvard University Michael D’Ambra, MD Boston, Massachusetts

1993-1996 Massachusetts General Hospital Anesthesiology Residency

Harvard University Warren Zapol, MD

1992-1993 Yale University Primary-Care Internal Medicine New Haven, Connecticut Internship Stephen Huot, MD, PhD

PROFESSIONAL 1987-1992 University of Pittsburgh MD, 1992

School of Medicine Pittsburgh, Pennsylvania

GRADUATE 2014-2018 Katz Graduate School of Business PhD, Organization Behavior and Anticipated University of Pittsburgh Human Resource Management

Pittsburgh, Pennsylvania Minor: Strategic Management 2011-2012 Katz Graduate School of Business MBA, International, 2012 University of Pittsburgh Pittsburgh, Pennsylvania 2001-2003 Auburn University/Southern Medical Business Administration Association Courses UNDERGRADUATE 1983-1987 University of Scranton: BS, 1987, Biology


CURRICULUM VITAE


3

A Jesuit Institution Minor, History Scranton, Pennsylvania Cognate, Chemistry

APPOINTMENTS AND POSITIONS ACADEMIC APPOINTMENTS 2005-present University of Pittsburgh Visiting Associate Professor

School of Medicine Pittsburgh, Pennsylvania

2004-2005 West Virginia University Associate Professor School of Medicine 1998-2004 West Virginia University Assistant Professor School of Medicine 1998 Harvard University Instructor School of Medicine 1993-1997 Harvard University Clinical Fellow School of Medicine NON-ACADEMIC APPOINTMENTS AND POSITIONS 2014-present Children’s Hospital of Pittsburgh of UPMC Director

Pittsburgh, Pennsylvania Transplant Anesthesiology

2014-present Children’s Hospital of Pittsburgh of UPMC Founding Member Pittsburgh, Pennsylvania Radiology Anesthesiology Team

2012-present Children’s Hospital of Pittsburgh of UPMC Founding Member

Pittsburgh, Pennsylvania Transplant Anesthesiology Team 2008-present Children’s Hospital of Pittsburgh of UPMC Director

Pittsburgh, Pennsylvania Perioperative Medical Services


CURRICULUM VITAE


4

2008-present Children’s Hospital of Pittsburgh of UPMC Chief Charge Anesthesiologist

Pittsburgh, Pennsylvania 2005-present Children’s Hospital of Pittsburgh of UPMC Director

Pittsburgh, Pennsylvania Trauma Anesthesiology 2005-present Children’s Hospital of Pittsburgh of UPMC Pediatric Transplant

Pittsburgh, Pennsylvania Anesthesiologist

2005-present Children’s Hospital of Pittsburgh of UPMC Pediatric Anesthesiologist Pittsburgh, Pennsylvania

2005-2011 UPMC Presbyterian Hospital Anesthesiologist

Pittsburgh, Pennsylvania 2007-2008 Children’s Hospital of Pittsburgh of UPMC Charge Anesthesiologist

Pittsburgh, Pennsylvania

2008 Children’s Hospital of Pittsburgh of UPMC Pediatric Pain Physician Pittsburgh, Pennsylvania

2008 Children’s Hospital of Pittsburgh of UPMC Interim Associate Director

Pittsburgh, Pennsylvania Perioperative Medical Services

2005-2008 Children’s Hospital of Pittsburgh of UPMC Pediatric Cardiac Anesthesiologist Pittsburgh, Pennsylvania

1998-2005 Ruby Memorial Hospital Charge Anesthesiologist

Robert C. Byrd Health Sciences Center West Virginia University Morgantown, West Virginia


CURRICULUM VITAE


5

1998-2005 Ruby Memorial Hospital Cardiac Anesthesiologist Robert C. Byrd Health Sciences Center West Virginia University Morgantown, West Virginia

1998-2005 Ruby Memorial Hospital Anesthesiologist


1998-2005 Chestnut Ridge Hospital Anesthesiologist


1998-2005 West Virginia University Children’s Hospital Pediatric Anesthesiologist

Robert C. Byrd Health Sciences Center West Virginia University

2003-2005 Ruby Memorial Hospital Intensivist


2003-2004 Allegheny General Hospital Director

Pittsburgh, Pennsylvania Trauma Anesthesiology 2003-2004 Allegheny General Hospital Cardiac Anesthesiologist

Pittsburgh, Pennsylvania 2003-2004 Allegheny General Hospital Pediatric Anesthesiologist

Pittsburgh, Pennsylvania


CURRICULUM VITAE


6

2003-2004 Allegheny General Hospital Anesthesiologist Pittsburgh, Pennsylvania

2003-2004 Allegheny General Hospital Intensivist

Pittsburgh, Pennsylvania 2003-2004 Forbes Regional Hospital Intensivist

Western Pennsylvania Anesthesiology Associates Monroeville, Pennsylvania

2000-2003 Monongalia General Hospital Chair

Morgantown, West Virginia Anesthesiology 2000-2003 Professional Anesthesia Services, North Chief

Monongalia General Hospital Anesthesiology Morgantown, West Virginia

2000-2003 Monongalia General Hospital Chief

Morgantown, West Virginia Pediatric Anesthesiology 2000-2003 Monongalia General Hospital Director

Morgantown, West Virginia Post Anesthesia Care 2000-2003 Monongalia General Hospital Intensivist

Morgantown, West Virginia 2000-2003 Monongalia General Hospital Anesthesiologist

Morgantown, West Virginia 2000-2003 Monongalia General Hospital Pediatric Anesthesiologist

Morgantown, West Virginia 1998-2003 Monongalia General Hospital Cardiac Anesthesiologist


CURRICULUM VITAE


7

Morgantown, West Virginia 1999-2000 Children’s Hospital of West Virginia Pediatric Intensivist


1998-2000 Ruby Memorial Hospital Intensivist


1998 Cardiac Anesthesia Group Director

Department of Anesthesia & Critical Care Pediatric Cardiac Anesthesiology Massachusetts General Hospital Boston, Massachusetts

1998 Department of Anesthesia & Critical Care Intensivist

Massachusetts General Hospital Boston, Massachusetts

1998 Department of Anesthesia & Critical Care Assistant in Anesthesia

Massachusetts General Hospital Boston, Massachusetts

1996-1998 Cardiac Anesthesia Group Cardiac Anesthesiologist

Department of Anesthesia & Critical Care Massachusetts General Hospital

1996-1998 Cardiac Anesthesia Group Pediatric Cardiac Anesthesiologist

Department of Anesthesia & Critical Care Massachusetts General Hospital


CURRICULUM VITAE


8

1996-1997 Department of Anesthesia & Critical Care Clinical Assistant in Anesthesia Massachusetts General Hospital Boston, Massachusetts

1989-1992 Medical Eye Bank of Western Pennsylvania Technician Pittsburgh, Pennsylvania

CERTIFICATION AND LICENSURE SPECIALTY CERTIFICATION American Board of Anesthesiology 2013 Pediatric Anesthesiology American Board of Anesthesiology 2009 (voluntary recertification) Anesthesiology 1998 (no expiration) American Board of Anesthesiology 1999 (no expiration) Critical Care Medicine Pediatric Advanced Life Support 2005 - present (2014 recertification) American Heart Association Basic Life Support 1982 - present (2014 recertification) American Heart Association Advanced Cardiac Life Support 1990-2006 American Heart Association Neonatal Advanced Life Support 2001-2004 American Heart Association Advanced Water Safety Instructor 1982-1990 American Red Cross


CURRICULUM VITAE


9

Advanced Water Safety 1981-1990 American Red Cross MEDICAL LICENSURE Pennsylvania # MD-065687-L 1998-present Massachusetts # 15244 1996-2005 West Virginia # 19439 1998-2004

MEMBERSHIP IN PROFESSIONAL AND SCIENTIFIC SOCIETIES American Academy of Physician Leaders 2014-present (formerly American College of Physician Executives) Society for Education in Anesthesia 2013-present, 1999-2003 Pediatric Trauma Society 2012-present American Academy of Pediatrics 2011-present Pennsylvania Society of Anesthesiologists 2008-present West Virginia Society of Anesthesiologists (Honorary) 2008-present Society for Pediatric Anesthesia 2005-present American Society of Anesthesiologists 1998-present International Trauma Anesthesia and Critical Care Society 2002-2009 Congenital Cardiac Anesthesia Society 2006-2008 West Virginia Society of Anesthesiologists 1998-2008


CURRICULUM VITAE


10

Society for Cardiovascular Anesthesiologists 1996-2008 Massachusetts Medical Society 1996-2006 American Medical Association 1987-2006 Southern Medical Association 2000-2005

Honors

Selected for Physician Leadership Academy 2010-present The Advisory Board Company and Children’s Hospital of Pittsburgh of UPMC Honorary Member 2006-present West Virginia Society of Anesthesiologists For Exemplary Contributions to the West Virginia Society of Anesthesiologists Alumni Hall of Fame 2015 Port Jervis High School Port Jervis, New York Visiting Professor 2015 University of Virginia School of Medicine Charlottesville, Virginia Selected as “Top Doctor” 2015 The Leading Physicians of the World International Association of Anesthesiologists Selected to Marquis’ “Who’s Who in America” 2015


CURRICULUM VITAE


11

Selected to Covington’s “Who’s Who in America” 2015 9/10 overall faculty evaluation 2015 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8.25/10 overall faculty evaluation 2015 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine

Visiting Professor 2014 St Jude Children’s Research Hospital Memphis, Tennessee Selected to “Executive Who’s Who” 2014 Selected to Marquis’ “Who’s Who in America” 2014 Selected to Covington’s “Who’s Who in America” 2014 9.07/10 overall faculty evaluation 2014 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 3.79/4 overall faculty evaluation 2014 Yearly student evaluation Anesthesiology Faculty Teaching Ranking Nurse Anesthesia Program University of Pittsburgh School of Nursing


CURRICULUM VITAE


12

Selected to “International Professional Registry” 2013 8.64/9 overall faculty evaluation 2013 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8.4/9 overall faculty evaluation 2013 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8/9 overall faculty evaluation 2013 Yearly medical student evaluation Department of Anesthesiology Medical Student Teaching Ranking University of Pittsburgh School of Medicine 3.54/4 overall faculty evaluation 2013 Yearly student evaluation Anesthesiology Faculty Teaching Ranking Nurse Anesthesia Program University of Pittsburgh School of Nursing Selected to “Executive Who’s Who” 2013 Selected to Stanford’s “Who’s Who in Business” 2013 Selected to Covington’s “Who’s Who in America” 2013 Selected to Marquis’ “Who’s Who in America” 2013 Selected to “The Global Registry” 2012


CURRICULUM VITAE


13

Selected for University Faculty Honors Convocation 2012 University of Pittsburgh Selected as “Most Supportive Anesthesia Staff Member” 2012 National Nursing Week Celebration Procedure Center Children’s Hospital of Pittsburgh of UPMC Selected to Marquis’ “Who’s Who in Business” 2012 Selected to Marquis’ “Who’s Who in America” 2012 8.47/9 overall faculty evaluation 2012 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8.71/9 overall faculty evaluation 2012 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 3.59/4 overall faculty evaluation 2012 Yearly student evaluation Anesthesiology Faculty Teaching Ranking Nurse Anesthesia Program University of Pittsburgh School of Nursing 7.94/9 overall faculty evaluation 2011 Yearly medical student evaluation Department of Anesthesiology Medical Student Teaching Ranking University of Pittsburgh School of Medicine


CURRICULUM VITAE


14

8.33/9 overall faculty evaluation 2011 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine Selected for University Faculty Honors Convocation 2011 University of Pittsburgh Selected to Marquis’ “Who’s Who in Business” 2011 Accepted as Fellow of American Academy of Pediatrics 2011 Selected to Cambridge Who's Who Registry Among 2011 Executives and Professionals Selected to Marquis’ “Who’s Who in America” 2011 Nominated Department of Anesthesiology’s Top Teacher 2011 University of Pittsburgh School of Medicine 19 nominated from faculty of > 220 8.88/9 overall faculty evaluation 2011 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8.33/9 overall faculty evaluation 2011 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine Selected one of “Pittsburgh’s Top Anesthesiologists” 2011 International Association of Anesthesiologists


CURRICULUM VITAE


15

Selected one of “Pittsburgh’s Top Anesthesiologists” 2010 International Association of Anesthesiologists Selected one of “America’s Top Anesthesiologists” 2010 “Guide to America’s Top Anesthesiologists” Consumers Research Council of America Selected to Marquis’ “Who’s Who in America” 2010 Visiting Professor 2010 University of Virginia School of Medicine Charlottesville, Virginia 8.88/9 overall faculty evaluation 2010 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8.58/9 overall faculty evaluation 2010 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine Selected one of “America’s Top Anesthesiologists” 2009 “Guide to America’s Top Anesthesiologists” Consumers Research Council of America Selected to Marquis’ “Who’s Who in America” 2009 8.78/9 overall faculty evaluation 2009 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking


CURRICULUM VITAE


16

University of Pittsburgh School of Medicine 8.63/9 overall faculty evaluation 2009 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 3.82/4 overall faculty evaluation 2009 Yearly student evaluation Anesthesiology Faculty Teaching Ranking Nurse Anesthesia Program University of Pittsburgh School of Nursing Visiting Professor 2009 West Virginia University School of Medicine Morgantown, West Virginia Selected one of “America’s Top Anesthesiologists” 2008 “Guide to America’s Top Anesthesiologists” Consumers Research Council of America Selected to “Who’s Who in America” 2008 8.67/9 overall faculty evaluation 2008 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8.46/9 overall faculty evaluation 2008 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine


CURRICULUM VITAE


17

3.55/4 overall faculty evaluation 2008 Yearly student evaluation Anesthesiology Faculty Teaching Ranking Nurse Anesthesia Program University of Pittsburgh School of Nursing Selected one of “America’s Top Anesthesiologists” 2007 “Guide to America’s Top Anesthesiologists” Consumers Research Council of America Selected to “Who’s Who in America” 2007 Visiting Professor: Memorial Regional Hospital 2007 Hollywood, Florida 8.72/9 overall faculty evaluation 2007 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8.625/9 overall faculty evaluation 2007 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine Selected one of “America’s Top Physicians” 2006 “Guide to America’s Top Physicians” Consumers Research Council of America Selected one of “America’s Top Anesthesiologists” 2006 “Guide to America’s Top Anesthesiologists” Consumers Research Council of America


CURRICULUM VITAE


18

8.95/9 overall faculty evaluation 2006 Yearly fellow evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine 8.92/9 overall faculty evaluation 2006 Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking University of Pittsburgh School of Medicine Selected one of “America’s Top Physicians” 2005 “Guide to America’s Top Physicians” Consumers Research Council of America Selected one of “America’s Top Anesthesiologists” 2005 “Guide to America’s Top Anesthesiologists” Consumers Research Council of America Written Board Question Writer 2005 American Board of Anesthesiology Visiting Professor: Cleveland Clinic March 2005 Cleveland, Ohio Oral Board Examiner 2004-2005 American Board of Anesthesiology Selected one of “America’s Top Anesthesiologists” 2004 “Guide to America’s Top Anesthesiologists” Consumers Research Council of America Top ranked faculty for overall yearly resident evaluation 2003-2004 Department of Anesthesiology Faculty Teaching Ranking


CURRICULUM VITAE


19

Western Pennsylvania Anesthesia Selected for American Society of Anesthesiologists’ 2004 Leadership Spokesperson Training Program One of thirty invited participants from ASA membership of 37,000 Washington, D.C. 4.67/5 score overall faculty evaluation 2003 Third ranked overall faculty Yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking West Virginia University School of Medicine 4.67/5 score overall faculty evaluation 2003 Second ranked overall faculty Yearly resident evaluation for Teaching Approaches Department of Anesthesiology Faculty Teaching Ranking West Virginia University School of Medicine 4.67/5 score overall faculty evaluation 2003 Third ranked overall faculty Yearly resident evaluation for Role Model Department of Anesthesiology Faculty Teaching Ranking West Virginia University School of Medicine Visiting Professor 2003 Cleveland Clinic Cleveland, Ohio Top ranked faculty 2002-2003 Overall yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking Western Pennsylvania Anesthesia


CURRICULUM VITAE


20

Highest overall ranked speaker with 4.63/5.00 2002 Pain and Anesthesiology Review West Virginia State Society of Anesthesiologists Annual Meeting White Sulfur Springs, West Virginia Top ranked part-time faculty 2000 Overall yearly resident evaluation Department of Anesthesiology Faculty Teaching Ranking West Virginia University School of Medicine Highest ranked speaker 2000 Year 2000: State of the Art in Anesthesiology Clinical Update on Anesthesiology, Pain Management & Critical Care West Virginia State Society of Anesthesiologists Annual Meeting White Sulfur Springs, West Virginia Highest rated speaker 2000 Fundamental Critical Care Support Course Society of Critical Care Medicine Center for Rural Emergency Medicine West Virginia University School of Medicine Morgantown West Virginia Top rated faculty with perfect 5/5 score 1999 Overall yearly resident evaluation Faculty Teaching Ranking Department of Anesthesiology West Virginia University School of Medicine Top rated faculty with perfect 5/5 score 1998 Overall yearly resident evaluation Faculty Teaching Ranking


CURRICULUM VITAE


21

Department of Anesthesiology West Virginia University School of Medicine Visiting Professor: University of New England 1996 College of Osteopathic Medicine Biddeford, Maine

PUBLICATIONS Refereed Articles 1. Ross, Faith J. M.D.; Metro, David G, M.D.; Beaman, Shawn T, M.D.; Cain, James G, M.D,

M.B.A., F.A.A.P; Dowdy, Monique; Apfel, A PhD, Jeong, J. PhD; Ibinson, James William, M.D., Ph.D; A First Look at the ACGME Anesthesiology Milestones: Implementation of Self-Evaluation in a Large Residency Program (2016) Journal of Clinical Anesthesia JCA-15-493 (Impact factor 1.194).

2. Callahan, P., Pinto, S. J., Kurland, G., Cain, J. G., Motoyama, E. K. and Weiner, D. J. (2015), Dexmedetomidine for infant pulmonary function testing. Pediatr. Pulmonol., 50: 150–154 (IF 2.704)

3. Jooste, Edmund, M.D.; Muhly, Wallis T, MD; Ibinson, James W, MD; Suresh, Tunga, M.B.B.S.; Damian, Daniela, MD; Phadke, Aparna, MD; Callahan Patrick, MD; Miller, Susan, MD; Feingold, Brian, MD; Lichtenstein, Steven E, MD; Cain, James G, MD; Chrysostomou, Constantinos, MD; Davis, Peter J, MD; Acute Hemodynamic Changes Following Rapid Intravenous Bolus Dosing of Dexmedetomidine in Pediatric Heart Transplant Patients Undergoing Routine Cardiac Catheterization, Anesth Analg, Dec;111(6):1490-6. Epub 2010 Nov 8 (Impact factor 3.27).

4. Sullivan, Pamela M; Sinz, Elizabeth H; Gunel, Erdogan; Cain, James G (erratum), Kofke W Andrew; A retrospective Comparison of Remifentanil Versus Methohexital for Anesthesia in Electroconvulsive Therapy, J ECT, 2004;20:219-224 (Impact factor 1.389).

Reviews 1. Shukry, Mohanad, Cain, James G., M.D., Dexmedetomidine treats agitation, delirium and

withdrawal, TraumaCare, 17:1:24-26, July 2007. Invited published papers


CURRICULUM VITAE


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1. Cain, James G., M.D., Critical Care, Pennsylvania Society of Anesthesiologists http://www.psanes.org/Anesthesiologists/ClinicalResources/StandardsPracticeParametersRecommendations/CriticalCare/tabid/177/Default.aspx, 2009.

2. Cain, James G., M.D., Malignant hyperthermia (MH) Management, Pennsylvania Society of Anesthesiologists, http://www.psanes.org/Anesthesiologists/ClinicalResources/StandardsPracticeParametersRecommendations/Preoperative/MalignantHyperthermiaMHManagement/tabid/178/Default.aspx, 2009

3. Cain, James G., M.D., International TraumaCare: The Leader in Cutting Edge TraumaCare, TraumaCare, 18:1:4-5, July 2008.

4. Cain, James G. and Grande, Christopher M., International TraumaCare: Critical Care for Critical Times, American Society of Anesthesiologists NEWSLETTER, 72:2:37-39, February 2008.

5. Cain, James G., M.D., Dexmedetomidine and Hextend: Their Role in Trauma Care, TraumaCare,17:1:3-5, July 2007.

6. Cain, James G., International TraumaCare, Association of University Anesthesiologists Newsletter, December 2005.

7. Cain, James G., M.D., “Damage Control” Anesthesiology Challenges in the United States, TraumaCare, 15:3:183-4, Fall 2005.

8. Cain, James G. and Grande, Christopher M., ITACCS Becomes International TraumaCare, American Society of Anesthesiologists NEWSLETTER, 69:11:38-39, November 2005.

9. Cain, James G., M.D., The President’s Message, TraumaCare, 15:3:117, Summer 2005. 10. Cain, James G., M.D., Trauma and Resuscitation International Group for Experimentation

and Research, Trauma Care, Summer 2003. 11. Cain, James G, M.D., Take the State Back From the Trial Lawyers, Guest Commentary,

Morgantown Dominion Post, February 18, 2003. 12. Cain, James G, M.D., Medical Malpractice, West Virginia University Department of

Anesthesiology Newsletter, February 6, 2003. 13. Cain, James G., M.D., "Business Education Should Be a Component of Medical Education:

Con", American Society of Critical Care Anesthesiologists Newsletter, March 2002. 14. Cain, James G., M.D. and Tesfaye, Jonas, M.D., “Pulmonary Trauma”, Current Opinions in

Anesthesia, April 2001, 14/2. 15. Cain, James G., M.D. and Smith, Charles, M.D., “Current Practices in Blood and Fluid


CURRICULUM VITAE


23

Management in Trauma”, Seminars in Anesthesia, Perioperative Medicine and Pain Management, 20;1:28-35, 2001.

16. Cain, James G., M.D., Kofke, W. Andrew, M.D., Sinz, Elizabeth H., M.D., Barbaccia, John J., M.D., Rosen, Kathleen R., M.D., “The West Virginia Human Crisis Simulation Program”, American Journal of Anesthesiology, 2000;27(4):215-220.

17. Kofke, W. Andrew, M.D., FCCM, Rosen, Kathy A.., M.D., Barbaccia, John, M.D., Sinz, Elizabeth, M.D., Cain, James, M.D., “The Value of Acute Care Simulation”, West Virginia Medical Journal, 2000 Mar-Apr;96(2):396-402.

Proceedings of conferences and symposia 1. Cain, James G., M.D.: Essentials of Pediatric Trauma: Trauma: The Team Approach to the

Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, St. Kitts, West Indies, April 2006.

2. Cain, James G., M.D.: Dexmedetomidine in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, St. Kitts, West Indies, April 2006.

3. Cain, James G., M.D.: Management of Hypotension in Trauma: Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, St. Kitts, West Indies, April 2006.

4. Cain, James G., M.D.: Fluid Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Trauma, St. Kitts, West Indies, April 2006.

5. Cain, James G., M.D.: Shock: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, St. Kitts, West Indies, April 2006.

6. Cain, James G., M.D.: Management of Hypertension in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Trauma St. Kitts, West Indies, April 2006.

7. Cain, James G., M.D.: Dexmedetomidine in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, South American Cruise, February 2006.

8. Cain, James G., M.D.: Spinal cord injury and brain trauma: Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures,


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Northwest Anesthesia Seminars, South American Cruise. 9. Cain, James G., M.D.: Management of Hypotension in Trauma: Trauma: Trauma: The Team

Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, South American Cruise, January 2006.

10. Cain, James G., M.D.: Fluid Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Trauma, South American Cruise, January 2006.

11. Cain, James G., M.D.: Shock: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, South American Cruise, January 2006.

12. Cain, James G., M.D.: Management of Hypertension in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Trauma, South American Cruise, January 2006.

13. Cain, James G., M.D., “Essentials of Pediatric Trauma Care”. 56th Annual Refresher Course Lectures and Basic Science Reviews, 153:1-7, American Society of Anesthesiologists, 2005.

14. Cain, James G., M.D.: Dexmedetomidine in Trauma Sedation Management: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Mediterranean Cruise, October 2005.

15. Cain, James G., M.D.: Management of Hypotension in Trauma: Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Mediterranean Cruise, October 2005.

16. Cain, James G., M.D.: Fluid Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Trauma, Mediterranean Cruise, October 2005.

17. Cain, James G., M.D.: Shock: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Mediterranean Cruise, October 2005.

18. Cain, James G., M.D.: Management of Hypertension in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare's Syllabus and Lectures, Northwest Anesthesia Seminars, Trauma, Mediterranean Cruise, October 2005.

19. Cain, James G., M.D.: Dexmedetomidine in Trauma Sedation Management: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical


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Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, European North Cape Cruise, June-July 2005.

20. Cain, James G., M.D.: Pediatric Cervical Spine Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, European North Cape Cruise, June-July 2005.

21. Cain, James G., M.D.: Cervical Spine Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, European North Cape Cruise, June-July 2005.

22. Cain, James G., M.D.: Management of Hypotension in Trauma: Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, European North Cape Cruise, June-July 2005.

23. Cain, James G., M.D.: Fluid Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Trauma, European North Cape Cruise, June-July 2005.

24. Cain, James G., M.D.: Shock: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, European North Cape Cruise, June-July 2005.

25. Cain, James G., M.D.: Management of Hypertension in Trauma, Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Trauma, European North Cape Cruise, June-July 2005.

26. Cain, James G., "Precedex in the trauma", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Maui, Hawaii, October 2004.

27. Cain, James G., "Pulmonary artery catheter: physiologically", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Maui, Hawaii, October 2004.

28. Cain, James G., "Fluid Management in Trauma", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus


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and Lectures, Northwest Anesthesia Seminars, Maui, Hawaii, October 2004. 29. Cain, James G., "Overdoses, Poisonings and Envenomations", Trauma: The Team

Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Maui, Hawaii, October 2004.

30. Cain, James G., "Cardiovascular pharmacology: shock", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Maui, Hawaii, October 2004.

31. Cain, James G., "Cervical spine management in trauma, Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Maui, Hawaii, October 2004.

32. Cain, James G., "Precedex in the critically injured patient", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Falmouth, Massachusetts, July 2004.

33. Cain, James G., "Pulmonary artery catheter in critically injured patients", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Falmouth, Massachusetts, July 2004.

34. Cain, James G., "Fluid Management in Trauma", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Falmouth, Massachusetts, July 2004.

35. Cain, James G., "Overdoses, Poisonings and Envenomations", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Falmouth, Massachusetts, July 2004.

36. Cain, James G., "Brain death and organ donation in the trauma patient", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Syllabus and Lectures, Northwest Anesthesia Seminars, Falmouth, Massachusetts, July 2004.

37. Cain, James G., "Fear", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Alaskan Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2003.

38. Cain, James G., "Swan Ganz Made Simple", Trauma: The Team Approach to the Clinical


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Challenge, International Trauma Anesthesia and Critical Care Society's Alaskan Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2003.

39. Cain, James G., "Hypertension in Trauma", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Alaskan Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2003.

40. Cain, James G., "Dexmedetomidine in Trauma", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Alaskan Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2003.

41. Cain, James G., "Overdoses, Poisonings and Envenomations", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Alaskan Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2003.

42. Cain, James G., "Traumatic Brain Injury", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Alaskan Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2003.

43. Cain, James G., "Fluid Management in Trauma", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Alaskan Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2003.

44. Cain, James G., "Trauma Sedation: Precedex”, Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Syllabus and Lectures, Northwest Anesthesia Seminars, November 2002.

45. Cain, James G., "Shock", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Syllabus and Lectures, Northwest Anesthesia Seminars, November 2002.

46. Cain, James G., "Cardiac Drugs: Hypotension", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Syllabus and Lectures, Northwest Anesthesia Seminars, November 2002.

47. Cain, James G., "Cardiac Drugs: Hypertension", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Syllabus and Lectures, Northwest Anesthesia Seminars, November 2002.

48. Cain, James G., "Traumatic Brain Injury", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Syllabus and Lectures, Northwest Anesthesia Seminars, 2002.


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49. Cain, James G., "Shock", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2001.

50. Cain, James G., "Current Concepts in Fluid and Blood Resuscitation", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2001.

51. Cain, James G., "Cardiac Drugs 1: Hypotension", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2001.

52. Cain, James G., "Cardiac Drugs 2: Hypertension", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2001.

53. Cain, James G., "PA Catheter Made Physiologically Simple", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2001.

54. Cain, James G., "Spinal Cord Injury and Traumatic Brain Injury", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2001.

55. Cain, James G., "Brain Death and Organ Donation", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2001.

56. Cain, James G., "Simulation in Trauma", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars, August 2001.

57. Cain, James G., "Drug Overdose, Poisonings, and Envenomations", Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise Syllabus and Lectures, Northwest Anesthesia Seminars,


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August 2001. Monographs 1. Cain, James G., M.D., Guest Editor, Dexmedetomidine and Hextend: Their Role in Trauma

Care, TraumaCare,17:1, July 2007. Book chapters 1. Cain J, Argalious M, Rajpal P, Alvarez A, Chapter Anesthesia, Atlas in Liver Surgery.

Molmeti E, de Santibanes M, de Santibanes E (editors), Jaypee Medical Inc, TBA 2. Cain, James G., Section Liver Transplantation, Chapter Transplantation, Smith's Anesthesia

for Infants and Children, 9th edition. Davis PJ, Cladis FP, Motoyama EK (editors), Philadelphia, Elsevier, 2017

3. Bane, Brian, Cain, James; “Protein Huffing and Puffing: Theophylline, Dietary Protein, CYP1a2, In Marcucci, et al, eds. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, 2015.

4. Adams P, Cain J. Trauma Anesthesiology. In: Sikka PK, Beaman ST, Street JA, eds. Basic Clinical Anesthesia. New York, NY; Springer; 2015.

5. Cladis, Franklin; M.D., Anixter, Miriam, M.D., Lichtenstein, Stephen, M.D., Cain, James G., M.D., Davis, Peter, M.D. "Organ Transplantation", A Practice of Anesthesia for Infants and Children, Ed. Cote, 2013.

6. Emerick, Trent; Cain, James; Crystalloids, The 5-Minute Anesthesia Consult, Ed. Singh-Radcliff, Wolters Kluwer Health, Lippincott Williams & Wilkins, 2012.

7. Cain, James G., Section 1 Pediatric Airway, Part 1 Cervical spine precautions, Smith's Anesthesia for Infants and Children, 7th edition. DVD, Davis PJ, Cladis FP, Motoyama EK (editors), Philadelphia, Elsevier, 2011.

8. Silviano, Barbieri, Pedro, Grande, Christopher M., Cain, James G., Boedeker, Ben, Grizales R., Clara Lucia. “Manejo de la Via Aerea en Trauma”, Chapter 16, pp 151-170, Trauma, 2nd Edicion, Ed. Ferrada, Ricardo and Rodriguez, Aurelio, 2009.

9. McCunn, Maureen, Sutcliffe, Anne, Mauritz, Walter, and the International Trauma Anesthesia and Critical Care Society (ITACCS) Critical Care Committee (Parr M, Dutton R, Kaplan L, Cain J, Pelinka L, Smith C, Tanaka K, Gieseke A, Bailey H, Lippert F, Stene J, Talor E, Hyder M. “ITACCS Management of Mechanical Ventilation in Critically Injured Patients”, Chapter 30, pp 465-470. Trauma Anesthesia, Ed. Smith 2008.


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10. Cladis, Franklin; M.D., Anixter, Miriam, M.D., Lichtenstein, Stephen, M.D., Cain, James G., M.D., Davis, Peter, M.D. "Organ Transplantation", A Practice of Anesthesia for Infants and Children, Ed. Cote, 2008.

11. Cain, James Gordon, Cohen. Jonathon B, Kistler, Eric B, Camporesi, Enrico M. “Shock”, Chapter 18, Trauma: Critical Care, Volume 2, Ed. Wilson, Grande, and Hoyt, 2007.

12. Cain, James G., Grande, Christopher M., Section 1 Pediatric Airway, Part 1 “Cervical Spine Precautions”, Smith's Anesthesia for Infants and Children, 7th edition. DVD, Motoyama EK, Davis PJ (editors), Philadelphia, Elsevier, 2005.

13. Cain, James G, M.D. “Specific Considerations with Cardiac Disease”. Clinical Anesthesia Procedures of the Massachusetts General Hospital, Sixth Edition. Ed. William Hurford, M.D., et al, Little, Brown and Company, Boston, 2002.

14. Suarez, Thomas, M.D., Cain, James G., M.D., “Valvular Heart Disease”. Critical Care Handbook of the Massachusetts General Hospital. 3rd Edition. Ed. William Hurford, M.D., Little, Brown and Company, Boston, 2000.

15. Suarez, Thomas, M.D., Cain, James G., M.D., “Pacemakers and Implantable Defibrillators”. Critical Care Handbook of the Massachusetts General Hospital. 3rd Edition. Ed. William Hurford, M.D., Little, Brown and Company, 2000.

16. Kwo, Jean, M.D. and Cain, James G., M.D. “Side Effects of Mechanical Ventilation”. Anesthesiology Resident’s Guide to Learning in the Intensive Care Unit. Ed. Lucy A. Weston, Ph.D., M.D., American Society of Critical Care Anesthesiologists, Park Ridge Illinois, 1999.

17. Cain, James G, M.D. and Wollman, Lisa, M.D. “Specific Considerations with Cardiac Disease”. Clinical Anesthesia Procedures of the Massachusetts General Hospital, Fifth Edition. Ed. William Hurford, M.D., et al, Little, Brown and Company, Boston, 1997.

18. Cain, James G., “Leiomyosarcoma”. Make-A-Wish Foundation Disease Reference Manual. Ed. Linda Barthauer, Make-A-Wish Foundation, Pittsburgh, 1987.

Abstracts 1. DiSilvio G, Jacoby M, Weiner D, Broussard A, Callahan P, Cain J, Intranasal

Dexmedetomidine & Midazolam: A Novel Sedation Technique for Infant PFT, Society for Pediatric Anesthesia, Phoenix, Arizona, March 2015.

2. Tuchman JB, Cassara A, Cain JG, Consumptive Coagulopathy and Epiglottis in an Infant with Kassabach Merritt Phenomenon, http://www.asahq.org/Annual-


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Meeting/Education/2012-Medically-Challenging-Cases.aspx, MCC224, American Society of Anesthesiologists Annual Meeting, Washington, D.C., October 2012.

3. Tuchman JB, Cain JG, Cassara A, Goldenhar Syndrome and the AirQ Intubating LMA, http://www.asahq.org/Annual-Meeting/Education/2012-Medically-Challenging-Cases.aspx, MCC 225, American Society of Anesthesiologists Annual Meeting, Washington, D.C., October 2012.

4. Tuchman JB, Cassara A, Cain JG, High Inspiratory EtCO2 Due to Internal Hole in Pediatric Single Limb-O Circuit, Medically Challenging Cases, http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=a98d4f35-8eb7-4204-b641-98ccbbab796e&cKey=d941bac3-9856-4d47-ae5a-52a72a1fbe11&mKey=%7bDAF3996A-1B4B-4255-BBF9-84C4F1532AAB%7d, American Society of Anesthesiologists Annual Meeting, Chicago, October 2011.

5. Tuchman JB, Cain JG, Cassara A, Cardiac Arrest During Neonatal Tracheostomy Secondary to Bronchspasm, Medically Challenging Cases, http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=b3cb1c4c-e6fb-4d5b-97a9-2111b3f20980&cKey=70b961cb-f420-4140-99ac-452141993dbe&mKey=%7bDAF3996A-1B4B-4255-BBF9-84C4F1532AAB%7d, American Society of Anesthesiologists Annual Meeting, Chicago, October 2011.

6. Cain J, Tuchman J, Cassara A, Urgent PICU Consult!: Medically Challenging Cases, http://ww.asahq.org/Annual-Meeting/Education/Medically-Challenging-Caese.aspx, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010.

7. Cain J, Tuchman J, Cassara A, 3 Week Old with Stickler Syndrome, CHD, s/p Release of Tongue Lip Adhesion, Desaturated in NICU on POD #8, with Subsequent Inability To Intubate or Ventilate:. Medically Challenging Cases, http://www.asahq.org/Annual-Meeting/Education/Medically-Challenging-Cases.aspx, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010.

8. Cain J, Tuchman J, Cassara A, 12 Month Old Undergoing a Living Donor Liver Transplant with Loss of EtCO2 and Inability to Ventilate via ETT with an Obstructive Mucous Plug in the Endotracheal Tube: Medically Challenging Cases, http://www.asahq.org/Annual-Meeting/Education/Medically-Challenging-Cases.aspx, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010.

9. Cain J, Tuchman J, Borland L, Cassara A, A 14 mo Female with Pierre Robin Syndrome Presents for Cleft Palate Repair and Has Laryngospasm during Induction: Medically


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Challenging Cases, http://www.asahq.org/Annual-Meeting/Education/Medically-Challenging-Cases.aspx, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010.

10. Cain J, Tuchman J, Cassara A, 12 yo with Aplastic Anemia and Pneumo-Hemothorax during Broviac Placement: Medically Challenging Cases, http://www.asahq.org/Annual-Meeting/Education/Medically-Challenging-Cases.aspx, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010.

11. Cain J, Tuchman J, Cassara A, Perioperative Midodrine (alpha 1 Agonist) Considerations: Medically Challenging Cases, http://www.asahq.org/Annual-Meeting/Education/Medically-Challenging-Cases.aspx, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010.

12. Tuchman J, Cassara A, Cain J, Airway Compromise in Interventional Radiology Suite after Thrombin Injection for Vertebral Artery Pseudoaneurysm, Society for Pediatric Anesthesiology, San Antonio, April 2010.

13. Cain J, Cassara A, Tuchman J, Use of the LMA to Facilitate Ventilation of Patient with a Tracheostomy Tube: Medically Challenging Cases, http://www2.asahq.org/web/index.asp, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

14. Cain J, Tuchman J, Cassara A, 7 year old boy with tracheostomy bleed: Medically Challenging Cases, http://www2.asahq.org/web/index.asp, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

15. Cain J, Tuchman J, Jooste E, Cassara A, 6 year old tracheostomy dependent child with tracheostomy bleeding and respiratory distress tracheal secondary to tracheal compression from a vertebral pseudoaneurysm: Medically Challenging Cases, http://www2.asahq.org/web/index.asp, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

16. Cassara A, Tuchman J, Cain J, An Octogenarian with Abdominal Aortic Aneurysm and the Need for Electroconvulsive Shock Therapy: Medically Challenging Cases, http://www2.asahq.org/web/index.asp, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

17. Cassara A, Tuchman J, Cain J, An Octogenarian with Severe Cardiac Disease and a Difficult Airway: Medically Challenging Cases, http://www2.asahq.org/web/index.asp, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

18. Woelfel S, Cassara A, Borland L, Cain J, Martin B, Yellon R, Telford C, Effects of


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Dexmedetomidine on Epiglottic and Tongue Base Collapse, Anesthesiology Research Day, University of Pittsburgh Department of Anesthesiology, Pittsburgh, Pennsylvania, May 2009.

19. Woelfel S, Cassara A, Borland L, Cain J, Martin B, Yellon R, Telford C, Effects of Dexmedetomidine on Epiglottic and Tongue Base Collapse, Society for Pediatric Anesthesia Annual Meeting, Jacksonville, Florida, March 2009.

20. Cain, James G., M.D, Alpha 2 Agonists in Trauma: ITACCS 2008 Cochin, 12th Annual Conference of International Trauma Anaesthesia & Critical Care Society, Indian Chapter, Cochin India, August 2008.

21. Cain, James G., M.D, Sedation and Analgesia in Pediatric Trauma: TraumaCare 2008 Program, 21st Annual Trauma and Critical Care Symposium, International Trauma Care, Yokohama Japan, June 2008.

22. Grande C, Murray B, Berg B, Cain J, Boedeker B., The Trauma Patient: Lessons Learned from Iraq, the Middle East and Elsewhere, NYSSA 61st Post Graduate Assembly, New York, December 2007.

23. Cain, James G., M.D, Alpha 2 Agonists in Trauma Care: TraumaCare 2007 Program, 20th

Annual Trauma and Critical Care Symposium, International Trauma Care, Las Vegas, May 2007.

24. Cain, James G., M.D., Alpha Agonists: Novel Techniques for Sedation in the Critically Injured, TraumaCare, 15:3:169, Summer 2005.

25. Cain, James G., M.D., Essentials of Pediatric Cervical Spinal Cord/Column Trauma Care, TraumaCare, 15:3:170, Summer 2005.

26. Calvert, Kelly, Cruzzavala, Jose, M.D., Cain, James, M.D., Filchick, Tammy, “Safe Off-pump Cardiopulmonary Bypass with Bivalirudin in a Patient with Heparin Induced Thrombocytopenia after Active Allergy to Lepirudin”, Southern Thoracic Surgical Association, Nov 2003.

27. Cain, James G, M.D., Sedation for the Critically Injured Trauma Patient: Precedex, a Novel Alternative, TraumaCare, Spring 2003.

28. Cain, James G, M.D., Human Crisis Simulation for Rural Medical Education, TraumaCare, Spring 2003.

29. Sinz, Elizabeth, M.D., Sullivan, Pamela, M.D., Cain, James, M.D., Kofke, W. Andrew, M.D., Remifentanil versus Methohexital for Electroconvulsive Therapy, Association of Convulsive Therapy, Journal of ECT. 2003.

30. Cain, J G, M.D., Sullivan, P, M.D., Boyd, D, MA, AA-C, Bezouska, C, MD, Kofke, W A, M.D.,


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Remifentanil Increases ECT Seizure Duration and Improves Beck’s Depression Score’s without Lowering Mini-mental Status Examinations, Anesthesiology vol 93, 3A, no. 267, September 2000.

31. Cain, J G, M.D., Sullivan, P, M.D., Kofke, W A, M.D., Remifentanil Decreases ECT Stimulus Required for Adequate Seizures, Society of Neuroanesthesia and Critical Care, 2000.

32. Cain, James, M.D., Sullivan, Pamela, M.D., Boyd, David, MA, AA-C, Kofke, W. Andrew, M.D., Remifentanil increases ECT seizure duration and improves Beck’s depression scores, Journal of ECT, Vol. 16, No. 1, 2000.

33. Cain, James G., M.D., Sullivan, Pamela, M.D., Sinz, Elizabeth, M.D., Kofke, W. Andrew, M.D., Remifentanil increases ECT seizure duration, no. 3A, A180, 1999 Sept.

34. Rosen, KR, M.D., Sinz, EH, M.D., Kofke, WA, M.D., Barbaccia, J, M.D., Cain, JG, M.D. Integration of the Human Patient Simulation into ACLS Curriculum, Anesthesia Education, 1999.

PROFESSIONAL ACTIVITIES

INTERNATIONAL EDUCATIONAL ACTIVITIES Judge: Poster Session, Safar Symposium, Pittsburgh, May 2014. Instructor: Simulation Program, Safar Symposium, Pittsburgh, May 2014. Organizing Committee: 2nd International Conference & Exhibition on Orthopedics and Rheumatology, Las Vegas 2013. Program Chair: Pediatric Trauma Anesthesiology, 15th Annual World Congress of Anesthesiology, Buenos Aires, 2012. Program Chair: Pediatric Cardiac Anesthesiology, 15th Annual World Congress of Anesthesiology, Buenos Aires, 2012. Program Chair: Trauma Anesthesiology Work Shop, 15th Annual World Congress of Anesthesiology, Buenos Aires, 2012. Chair, Moderator and Judge: Poster Session, TraumaCare 2008 Program, 21st Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Yokohama Japan, June 2008. Chair: TraumaCare2007 Program (20 CME hours), 20th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Las Vegas, May 2007. Moderator and Judge: Poster Session, TraumaCare2007 Program (20 CME hours), 20th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care


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Society, Las Vegas, May 2007. Board of Directors: TraumaCare 2006 Program, 19th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Santiago, Chile, September 2006. Co-Director: ACCME Recredentialing, International TraumaCare, 2005-2006. Instructor: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, St. Kitts, West Indies, April 2006. Lecturer: Manejo de la via aerea y ventilacion en la emergencia, Ateno Abierto de Anesthesia, Terapia Intensiva y Emergencia, Hospital Britannico de Buenos Aires, Argentina, February 2006. Instructor: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, Mediterranean Cruise, October 2005. Instructor: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, European North Cape Cruise, June-July 2005. Program Co-Director: TraumaCare 2005 Program, 18th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Paris, May 2005. Moderator and Judge: Poster Session, TraumaCare 2005 Program, 18th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Paris, May 2005. Co-moderator: The Inner Circle Wealth Strategies Forum, BFI Consulting AG (Zurich-Embatingen, Switzerland), Nassau, Bahamas, January 2005. Instructor: TraumaCare2003 Program, 17th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Sydney, Australia, October 2004. Instructor: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, Maui, Hawaii, October 2004. Moderator and Judge: Poster Session, TraumaCare 2004 Program, 17th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Sydney, September 2004. Instructor: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, Falmouth, Massachusetts, July 2004. Instructor: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, Alaska, August 2003. Chair: TraumaCare 2003 Program, 16th Annual Trauma Anesthesia and Critical Care


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Symposium, International Trauma Anesthesia and Critical Care Society, Dallas, May 2003. Scientific Program Director: TraumaCare2003 Program, 16th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Dallas, May 2003. Chair: New Directions in Trauma Anesthesia and Critical Care Session, TraumaCare2003 Program, International Trauma Anesthesia and Critical Care Society, Dallas, May 2003. Chair: Trauma Education, Simulation, and Patient Safety Session, TraumaCare2003 Program, International Trauma Anesthesia and Critical Care Society, Dallas, May 2003. Instructor: New Directions in Trauma Anesthesia and Critical Care Session, TraumaCare2003 Program, International Trauma Anesthesia and Critical Care Society, Dallas, May 2003. Instructor: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, Turks and Caicos, November 2002. Director and Instructor: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, Mediterranean Cruise, August 2001. NATIONAL EDUCATIONAL ACTIVITIES Instructor: Topics in Anesthesia: Emphasis on Trauma, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Arlington, Virginia, June 2016 Instructor: Topics in Anesthesia: Emphasis on Trauma, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Lake Tahoe, February 2016 Instructor: University of Pittsburgh’s Department of Anesthesiology’s Video Basic Board Review Course, Pittsburgh, Pennsylvania, June 2015 Instructor: University of Pittsburgh’s Department of Anesthesiology’s Video Advanced Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, June 2015. Participant: Society for Education in Anesthesia’s Workshop for Creation of Next Accrediting System (NAS) Milestone’s Template, Salt Lake City, Utah, May-June 2013. Instructor: University of Pittsburgh’s Department of Anesthesiology Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, March 2012. Instructor: University of Pittsburgh’s Department of Anesthesiology Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, March 2011. Instructor: University of Pittsburgh’s Department of Anesthesiology Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, April 2010.


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Instructor: University of Pittsburgh’s Department of Anesthesiology Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, April 2009. Instructor: Difficult Airway Workshop, American Society of Anesthesiologists Annual Meeting, San Francisco, October 2007. Lecturer: Refresher Course Lecture, American Society of Anesthesiologists Annual Meeting, Atlanta, October 2005. Oral Board Examiner: American Board of Anesthesiology, San Francisco, September 2005. Instructor: Fundamental Critical Care Support Course, American Society of Critical Care Medicine, 1999-2003. Instructor: Harvard Combined Critical Care Review Course, Airway Management Workshop, Cambridge, Massachusetts, April 1998. STATE EDUCATIONAL ACTIVITIES Contributing Author: Patient Education, Pennsylvania Society of Anesthesiologists Website, 2008-present. Organizing Committee: West Virginia State Society of Anesthesiologists Annual Meeting, 2000-2008. Instructor: West Virginia State Society of Anesthesiologists Annual Meeting, White Sulfur Springs, West Virginia, May 2005. Instructor: West Virginia State Society of Anesthesiologists Annual Meeting, White Sulfur Springs, West Virginia, May 2004. Instructor: West Virginia State Society of Anesthesiologists Annual Meeting, White Sulfur Springs, West Virginia, May 2003. Instructor: West Virginia State Society of Anesthesiologists Annual Meeting, White Sulfur Springs, West Virginia, May 2001. Instructor: West Virginia State Society of Anesthesiologists Annual Meeting, White Sulfur Springs, West Virginia, May 2000. Instructor: Rhode Island Society of Anesthesiologists 10th Annual Meeting, Providence, Rhode Island, September 2004. Instructor: CMC Trauma Conference, Scranton, Pennsylvania, April 2004. UNIVERSITY EDUCATIONAL ACTIVITIES Board of Directors: Management Simulation Course, MBA Program, Katz School of Business,


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University of Pittsburgh, 2014-present. Board of Directors: Management Simulation Course, MBA Program, Katz School of Business, University of Pittsburgh, Summer Semester 2015. Board of Directors: Management Simulation Course, MBA Program, Katz School of Business, University of Pittsburgh, Spring Semester 2015. Facilitator: Diversity Workshop Series, University of Pittsburgh School of Medicine, 2014-present. Judge: Management Simulation Course, Executive MBA Worldwide, Global Forum, Katz School of Business, University of Pittsburgh, July 2013. Executive Panel Moderator: Third Annual Katz-Echo Global R&D and Collaboration Forum: Leading Organizations to Innovate Smarter, University of Pittsburgh Katz School of Business, Pittsburgh, January 2013. Instructor: Pediatric Anesthesia Update, University of Pittsburgh Department of Anesthesiology School of Nursing, Nurse Anesthesia Program, November 2008. Director and Instructor: Section: Ventilator Management, Fundamental Critical Care Support Course, Society of Critical Care Medicine, Center for Rural Emergency Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, September 2000. Director and Instructor: Section: Pediatric and Adult Airway Management, Fundamental Critical Care Support Course, Society of Critical Care Medicine, Center for Rural Emergency Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, March 2000. Director and Instructor: Section: Diagnosis and Management of Shock, Fundamental Critical Care Support Course, Society of Critical Care Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, March 1999. Director and Instructor: Section: Myocardial Ischemia and Infarction, Fundamental Critical Care Support Course, Society of Critical Care Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, March 1999. Director and Instructor: Section: Pediatric and Adult Airway Management, Fundamental Critical Care Support Course, Society of Critical Care Medicine, Morgantown, West Virginia University School of Medicine, West Virginia, March 1999. Instructor and tutor: Neuroscience Review Course, University of Pittsburgh School of Medicine, 1990. Didactic instruction of neuroscience to medical students. HOSPITAL/HEALTH SYSTEM EDUCATIONAL ACTIVITIES


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Instructor: Sedation Education, Children’s Hospital of Pittsburgh of UPMC, 2010-2014. Director: Sedation Education, Monongalia General Hospital, 2000-2003. DEPARTMENTAL EDUCATIONAL ACTIVITIES Founding Member: Pediatric Fellowship Evaluation and Competency Committee, Department of Anesthesiology, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh, 2013-present. Chair and Founding Member: UPMC Department of Anesthesiology Residency Program’s Milestones Evaluation Committee, 2012-present. Committee Member: Working Group to Improve WISER’s Assessment Capabilities, Simulation Program, WISER (Peter M. Winter Institute for Simulation Education and Research), Department of Anesthesiology, University of Pittsburgh, 2013-present. Instructor: Resident Simulation Program, WISER (Peter M. Winter Institute for Simulation Education and Research, Department of Anesthesiology, University of Pittsburgh, 2013-present. Chair: Resident Evaluation and Competency Committee, Department of Anesthesiology, University of Pittsburgh, 2011-present. Developed Department NAS Milestones Resident Evaluation Process 2012-2103. Redesign of resident evaluation process 2013-2015. Developed Feedback Friday Departmental Residency Feedback Program 2016-preseent. Committee Member: Program Review Committee, Department of Anesthesiology, University of Pittsburgh, 2011-present. Committee Member: Resident Curriculum Committee, Department of Anesthesiology, University of Pittsburgh, 2011-present. Committee Member: Medical Student Curriculum Committee, Department of Anesthesiology, University of Pittsburgh, 2011-present. Committee Member: Resident Evaluation Committee, Department of Anesthesiology, University of Pittsburgh, 2011-present. Committee Member: Pediatric Fellowship Curriculum Committee, Department of Anesthesiology, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh, 2008-present. Committee Member: Pediatric Advanced Airway Management, Pediatric Anesthesiology Fellowship, Children’s Hospital of Pittsburgh, University of Pittsburgh Department of Anesthesiology, 2008-present. Committee Member: Resident Evaluation and Competency Committee, Department of


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Anesthesiology, University of Pittsburgh, 2007-present. Committee Member: Resident Education Committee, Department of Anesthesiology, University of Pittsburgh, 2007-present. Director: Introduction to Resident Milestone Evaluations Workshop, Department of Anesthesiology, University of Pittsburgh, February 2013. Instructor: University of Pittsburgh’s Third Annual Postgraduate Anesthesia Conference, June 2006. Lecturer: Children’s Hospital of Pittsburgh Pediatric Anesthesia Update Symposium, University of Pittsburgh, Pittsburgh, March 2006. Moderator: Pediatric Anesthesia Key Word Session: Congenital Diaphragmatic Hernia and Tracheoesophageal Fistula, Children’s Hospital of Pittsburgh, University of Pittsburgh, December 2005 Instructor: Anesthesiology Orientation Lectures, Department of Anesthesiology, West Virginia University School of Medicine, January 2001. Chair: Resident Evaluation and Competency Committee, Department of Anesthesiology, West Virginia University School of Medicine, 2000-2001. Committee Member: Resident Evaluation and Competency Committee, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2001. Committee Member: Education Committee, Department of Anesthesiology, West Virginia University School of Medicine, 1998-2001. Director and Instructor: Section of Invasive Monitoring, West Virginia University School of Medicine, Clinical Skills Course for Second Year Medical Students, 1998-2001. Instructor: Anesthesiology Orientation Lectures, Department of Anesthesiology, West Virginia University School of Medicine, January 2000. Director: Cardiac Anesthesia Fellowship, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2000. Committee Member: Department of Anesthesiology Promotions and Tenure Committee, West Virginia University School of Medicine, 1998-2000. Co-Director and Instructor: Cardiovascular Anesthesia Education, Department of Anesthesia, West Virginia University School of Medicine, 1998-2000. Instructor: Morning Report, Department of Anesthesiology, West Virginia University School of Medicine, 1998-2000. Instructor: Anesthesiology Orientation Lectures, Department of Anesthesiology, West Virginia


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University School of Medicine, July 1999. Committee Member: Fellow Evaluation and Competency Committee, Department of Anesthesia & Critical Care, Massachusetts General Hospital, 1998 Director: Program for education on non-operating room use of laryngeal mask airway, including assisting in development of pilot program for education and instruction of critical care nurses in LMA use, Department of Anesthesia & Critical Care, Massachusetts General Hospital, 1997-1998. Instructor: ACLS Review Course, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1998. Director: Journal Club, Department of Anesthesiology & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, 1997-1998. Coordinator: Guidelines for invasive monitoring in the intensive care unit, Department of Anesthesia & Critical Care, Massachusetts General Hospital, 1997-1998. Instructor: ACLS Review Course, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, November 1997. Instructor: ACLS Review Course, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, September 1997. Instructor: ACLS Review Course, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, July, 1997. Instructor: Harvard Combined Critical Care Review Course, Airway Management Workshop, Cambridge, April 1997. DEPARTMENTAL ADVISER/MENTOR Faculty Adviser: Kristian Werneid, M.D., Anesthesiology Resident, UPMC, University of Pittsburgh Department of Anesthesiology, 2011-2014. Faculty Adviser: Bryan Fritz, M.D., Pediatric Anesthesiology Fellow, Children’s Hospital of Pittsburgh of UPMC, University of Department of Anesthesiology, 2009-2010. Faculty Adviser: Idi Allen, M.D., Pediatric Anesthesiology Fellow, Children’s Hospital of Pittsburgh of UPMC, University of Department of Anesthesiology, 2008-2009. Faculty Advisor: Faculty advisor to Jonas Tesfaye, M.D., Resident, Department of Anesthesiology, West Virginia University School of Medicine, 1998-2001. Faculty Mentor: Faculty mentor for Carla Rodriguez, First Month Resident Orientation, Department of Anesthesiology, West Virginia University School of Medicine, January 2000.


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Faculty Mentor: Faculty mentor for Paul Talbot, M.D, First Month Resident Orientation, Department of Anesthesiology, West Virginia University School of Medicine, July 1999. DEPARTMENTAL MOCK ORAL BOARD EXAMINER 1. Mock Oral Board Examiner: Resident: Ritesh Senapati, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, June 2016. 2. Mock Oral Board Examiner: Resident: Rachel Pool, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, November 2015. 3. Mock Oral Board Examiner: Resident: Meghan Cohen, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, September 2015. 4. Mock Oral Board Examiner: Fellow: Allison Jeziorski M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, June 2015. 5. Mock Oral Board Examiner: Fellow: Christian Werneid M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, May 2015. 6. Mock Oral Board Examiner: Fellow: Adam Broussard M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, April 2015. 7. Mock Oral Board Examiner: Fellow: Usman Shah M.D., University of Pittsburgh Department

of Anesthesiology Mock Oral Board Exam Program, April 2015. 8. Mock Oral Board Examiner: Fellow: Abdalrahim Agendy M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, April 2015. 9. Mock Oral Board Examiner: Fellow: Usman Shah M.D., University of Pittsburgh Department

of Anesthesiology Mock Oral Board Exam Program, March 2015. 10. Mock Oral Board Examiner: Resident: Andrew Clary, D.O., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, September 2014. 11. Mock Oral Board Examiner: Resident: Daniel Ford, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, June 2014. 12. Mock Oral Board Examiner: Fellow: Elizabeth Gail Shaffer, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, April 2014. 13. Mock Oral Board Examiner: Resident: Patrick Hackett, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, September 2013. 14. Mock Oral Board Examiner: Resident: Daniela Damian, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, June 2013. 15. Mock Oral Board Examiner: Fellow: Akhil Rastogi, M.D., University of Pittsburgh Department


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of Anesthesiology Mock Oral Board Exam Program, March 2013. 16. Mock Oral Board Examiner: Faculty: Scott Muir, M.D., University of Pittsburgh Department

of Anesthesiology Mock Oral Board Exam Program, February 2013. 17. Mock Oral Board Examiner: Resident: Jill Sagonda-Gerrero, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, June 2012. 18. Mock Oral Board Examiner: Resident: Anthony Silipo, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, May 2012. 19. Mock Oral Board Examiner: Fellow: Kathleen Barrett, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, May 2012. 20. Mock Oral Board Examiner: Fellow: Tara Knizner, M.D., University of Pittsburgh Department

of Anesthesiology Mock Oral Board Exam Program, May 2012. 21. Mock Oral Board Examiner: Fellow: R. Scott Lang, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2012. 22. Mock Oral Board Examiner: Fellow: Brian Blasiole, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2012. 23. Mock Oral Board Examiner: Fellow: Amelia Randall, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2012. 24. Mock Oral Board Examiner: Faculty: Kristin Ondecko Ligda, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2012. 25. Mock Oral Board Examiner: Fellow: Gabriel Yacob, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2012. 26. Mock Oral Board Examiner: Fellow: R. Scott Lang, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2012. 27. Mock Oral Board Examiner: Fellow: Brian Blasiole, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2012. 28. Mock Oral Board Examiner: Fellow: Amelia Randall, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2012. 29. Mock Oral Board Examiner: Resident: Totulope Coker, M.D., Children’s Hospital of

Pittsburgh of UPMC Department of Anesthesiology Mock Oral Board Exam Program, November 2011.

30. Mock Oral Board Examiner: Resident: Scott Muir, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, June 2011.

31. Mock Oral Board Examiner: Resident: R. Scott Lang, M.D., University of Pittsburgh


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Department of Anesthesiology Mock Oral Board Exam Program, April 2011. 32. Mock Oral Board Examiner: Fellow: Kuo Nguyen, M.D., University of Pittsburgh Department

of Anesthesiology Mock Oral Board Exam Program, April 2011. 33. Mock Oral Board Examiner: Fellow: Ralph Beltran, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, April 2011. 34. Mock Oral Board Examiner: Resident: Dan Mulcrone, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, November 2010. 35. Mock Oral Board Examiner: Faculty: Babak Mayer, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, April 2010. 36. Mock Oral Board Examiner: Resident: Walid Osta, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2010. 37. Mock Oral Board Examiner: Resident: Philip Chuang, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, December 2009. 38. Mock Oral Board Examiner: Resident examinee: Ted Ley, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, November 2009. 39. Mock Oral Board Examiner: Resident examinee: Charles Lin, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, September 2009. 40. Mock Oral Board Examiner: Fellow examinee: Idi Allen, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, July 2009. 41. Mock Oral Board Examiner: Fellow examinee: Reza Mohammad, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, July 2009. 42. Mock Oral Board Examiner: Resident examinee: Denise Hall-Burton, M.D. University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, April 2009. 43. Mock Oral Board Examiner: Resident examinee: Richard McAfee, M.D. University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, April 2009. 44. Mock Oral Board Examiner: Fellow examinee: Patrick Callahan M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, April 2009. 45. Mock Oral Board Examiner: Fellow examinee: Erica Schmitt, University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, April 2009. 46. Mock Oral Board Examiner: Fellow examinee: Patrick Callahan M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, March 2009. 47. Mock Oral Board Examiner: Fellow examinee: Leo Mussachia M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2009.


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48. Mock Oral Board Examiner: Resident examinee: Janelle Nielsen, D.O. University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, February 2009.

49. Mock Oral Board Examiner: Resident examinee: Lavinia Kolarczyk, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, December 2008.

50. Mock Oral Board Examiner: Fellow examinee: Jay Tuchman M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, October 2008.

51. Mock Oral Board Examiner: Resident examinee: Adam Tune M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, September 2008.

52. Mock Oral Board Examiner: Fellow examinee: Jay Tuchman M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, September 2008.

53. Mock Oral Board Examiner: Fellow examinee: Tonga Suresh M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, April 2008.

54. Mock Oral Board Examiner: Fellow examinee: Roy Berenholtz, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, April 2008.

55. Mock Oral Board Examiner: Fellow examinee: Tonga Suresh M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, March 2008.

56. Mock Oral Board Examiner: Fellow examinee: Codruto Soneru, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, March 2008.

57. Mock Oral Board Examiner: Fellow examinee: Antonio Cassara, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, March 2008.

58. Mock Oral Board Examiner: Faculty examinee: Scott Brancolini, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, September 2007.

59. Mock Oral Board Examiner: Resident examinee: Vahid Grami, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, September 2007.

60. Mock Oral Board Examiner: Fellow examinee: Christopher Stemland, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, April 2007.

61. Mock Oral Board Examiner: Resident examinee: Ivan Colaizzi, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, March 2007.

62. Mock Oral Board Examiner: Faculty examinee: Igor Seminov, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, September 2006.

63. Mock Oral Board Examiner: Resident examinee: Arnand Dugar, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, September


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2006. 64. Mock Oral Board Examiner: Examinee: David Provenzano, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, September 2006. 65. Mock Oral Board Examiner: Faculty examinee: Aparna Phadke, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, August 2006. 66. Mock Oral Board Examiner: Fellow examinee: Michael Marzouk, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, July 2006. 67. Mock Oral Board Examiner: Fellow examinee: Michael Marzouk, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, June 2006. 68. Mock Oral Board Examiner: Resident examinee: Avidan Rappaport, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, March 2006. 69. Mock Oral Board Examiner: Resident examinee: Dewan Haque., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2006. 70. Mock Oral Board Examiner: Resident examinee: Helen Lim, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, March 2006. 71. Mock Oral Board Examiner: Resident examinee: Mario Montoya, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, January 2005. 72. Mock Oral Board Examiner: Resident examinee: Andrea Tan, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, January 2005. 73. Mock Oral Board Examiner: Resident examinee: Tom Chalifoux, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, January 2005. 74. Mock Oral Board Examiner: Resident examinee: Mario De Angelis, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, November 2005. 75. Mock Oral Board Examiner: Resident examinee: Bijo Thomas, M.D., University of Pittsburgh

Department of Anesthesiology Mock Oral Board Exam Program, November 2005. 76. Mock Oral Board Examiner: Resident examinee: David Whiting, M.D., University of

Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, September 2005.

77. Mock Oral Board Examiner: Resident examinee: Eric Davidson, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, September 2005.

78. Mock Oral Board Examiner: Fellow examinee: Harshad Guraney, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, July 2005.


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79. Mock Oral Board Examiner: Resident examinee: Monica Bolland, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, June 2005.

80. Mock Oral Board Examiner: Case: Resident examinee: Levi Zimmerman, M.D., University of Pittsburgh Department of Anesthesiology Mock Oral Board Exam Program, June 2005.

COMMERCIAL EDUCATIONAL ACTIVITIES Consultant: Leydig, Voit & Mayer Ltd., Chicago, Illinois, 2015 - present. Drug Safety Monitoring Board: Hospira 2010-2104. Speaker’s Bureau: Hospira, Precedex Education, 2004-2013. Speakers Bureau: NeurogesX, 2009-2012. Speaker’s Bureau: Abbott Laboratories, Precedex Education, 2002-2004. Speaker’s Bureau: Abbott Laboratories, Ultiva Education, 2001-2004. INTERNATIONAL PRESENTATIONS AND INVITED LECTURES 1. Invited Speaker: A Fresh New Insight on Promotion of Healthy Hearts, 8th Annual International

Congress of Cardiology China-2016, Xi'an, China, December 2016. 2. Invited Speaker: Pediatric Cardiac Anesthesiology: Update, the 7th Annual International

Congress of Cardiology, China, 2015. 3. Invited Speaker: Sudden Cardiac Death/Arrest/Cardiac Emergencies, Forum 2212, the 6th

Annual International Congress of Cardiology, Haikuo, China, December 2014. 4. Invited Distinguished Guest Speaker: Professional Educational Society’s Galapagos CME

Adventure, Galapagos Islands, June 2014. 5. Invited Speaker: Innovations and Advances in Anesthesiology, Indo-Global Healthcare

Summit & Expo 2014, Hyderabad, India, June 2014. 6. Speaker: Evaluation of Transplant Anesthesiology Services at the Hospital Cardioinfantil,

Bogota, Columbia, May 2014. 7. Invited Speaker: 5th International Congress of Cardiology (ICC-2013), Rome Italy,

December 2013. 8. Invited Speaker: 5th International Congress of Cardiology (ICC-2013), Rome Italy,

December 2013. 9. Invited Plenary Session Speaker: 2nd International Conference & Exhibition on Orthopedics

and Rheumatology, Las Vegas August 2013. 10. Invited Speaker: Current practices in fluid and blood component therapy in trauma, Session


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515: Cardiac Trauma and Shock, the 4th International Congress of Cardiology, Guangzhou, China, December 2012.

11. Invited Speaker: New Strategies in Anesthesia and Perioperative Care, International Conference on Anesthesia and Perioperative Care, San Antonio, November 2012.

12. Invited Speaker: New Insights in the Field of Rheumatology, International Conference and Exhibition on Rheumatology & Therapeutics, Chicago, August 2012.

13. Lessons from Haiti: Disaster and Mass Casualty Medicine: Trauma Workshop, World Congress of Anesthesia, Buenos Aires, March 2012.

14. Dexmedetomidine in Pediatric Trauma Care: Pediatric Trauma Session, World Congress of Anesthesia, Buenos Aires, March 2012.

15. Dexmedetomidine: Pediatric Airway Management: International Symposium on Pediatric Airway, Denver, Colorado, June 2011.

16. Pulmonary Trauma: EPS Montreal International Trauma Forum 2011, Montreal Canada, June 2011.

17. The ITACCS 2008 Cochin Inaugural Address: The State of TraumaCare: ITACCS 2008 Cochin, 12th Annual Conference of International Trauma Anaesthesia & Critical Care Society, Indian Chapter, Cochin India, August 2008.

18. The ITACCS annual invitation lecture: Alpha 2 Agonists in Trauma: ITACCS 2008 Cochin, 12th Annual Conference of International Trauma Anaesthesia & Critical Care Society, Indian Chapter, Cochin India, August 2008.

19. TraumaCare 2008: The President’s Message : TraumaCare 2008 Program, 21st Annual Trauma and Critical Care Symposium, International Trauma Care, Yokohama Japan, June 2008.

20. Sedation and Analgesia in Pediatric Trauma: TraumaCare 2008 Program, 21st Annual Trauma and Critical Care Symposium, International Trauma Care, Yokohama Japan, June 2008.

21. Alpha 2 Agonists in Trauma Care: TraumaCare 2007 Program, 20th Annual Trauma and Critical Care Symposium, International Trauma Care, Las Vegas, May 2007.

22. TraumaCare 2007: The President’s Message TraumaCare 2007 Program, 20th Annual Trauma and Critical Care Symposium, International Trauma Care, Las Vegas, May 2007.

23. Dexmedetomidine in Trauma Care: TraumaCare 2006 Program, 19th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Santiago, Chile, September 2006.


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24. TraumaCare 2006: The President’s Message: TraumaCare 2006, 19th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Santiago, Chile, September 2006.

25. TraumaCare: Buenos Aires Anesthesia Society, Buenos Aires, Argentina, September 2006. 26. Healthcare Trends: Columbus University School of Nursing, Panama City, Panama,

September 2006. 27. Essentials of Pediatric Trauma: Trauma: The Team Approach to the Clinical Challenge,

International Trauma Anesthesia and Critical Care Society, St. Kitts, West Indies, April 2006. 28. Dexmedetomidine in Trauma: Trauma: The Team Approach to the Clinical Challenge,

International Trauma Anesthesia and Critical Care Society, St. Kitts, West Indies, April 2006. 29. Management of Hypotension in Trauma: Trauma: Trauma: The Team Approach to the

Clinical Challenge, International Trauma Anesthesia and Critical Care Society, St. Kitts, West Indies, April 2006.

30. Fluid Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, St. Kitts, West Indies, April 2006.

31. Shock: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, St. Kitts, West Indies, April 2006.

32. Management of Hypertension in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, St. Kitts, West Indies, April 2006.

33. Sedación en cuidados críticos / Dexmedetomidina®: Manejo de la via aerea y ventilacion en la emergencia, Ateno Abierto de Anesthesia, Terapia Intensiva y Emergencia, Hospital Britannico de Buenos Aires, Argentina, February 2006.

34. Lesión de columna cervical y manejo de la vía aérea: Manejo de la via aerea y ventilacion en la emergencia, Ateno Abierto de Anesthesia, Terapia Intensiva y Emergencia, Hospital Britannico de Buenos Aires, Argentina, February 2006.

35. Dexmedetomidine in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, South American Cruise, February 2006.

36. Spinal cord injury and brain trauma: Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, South American Cruise.

37. Management of Hypotension in Trauma: Trauma: Trauma: The Team Approach to the


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Clinical Challenge, International Trauma Anesthesia and Critical Care Society, South American Cruise, January 2006.

38. Fluid Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, Trauma, South American Cruise, January 2006.

39. Shock: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, South American Cruise, January 2006.

40. Management of Hypertension in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society, South American Cruise, January 2006.

41. Dexmedetomidine in Trauma Sedation: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, Mediterranean Cruise, October 2005.

42. Hypotension in Trauma: Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, Mediterranean Cruise, October 2005.

43. Fluid Management in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, Mediterranean Cruise, October 2005.

44. Shock: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, Mediterranean Cruise, October 2005.

45. Hypertension in Trauma: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, Mediterranean Cruise, October 2005.

46. Dexmedetomidine in Trauma Sedation Management: Trauma: The Team Approach, International TraumaCare, European North Cape Cruise, June-July 2005.

47. Pediatric Cervical Spine Management in Trauma: Trauma: The Team Approach, International TraumaCare, European North Cape Cruise, June-July 2005.

48. Cervical Spine Management in Trauma: Trauma: The Team Approach, International TraumaCare, European North Cape Cruise, June-July 2005.

49. Management of Hypotension in Trauma: Trauma: The Team Approach, International TraumaCare, European North Cape Cruise, June-July 2005.

50. Fluid Management in Trauma: Trauma: The Team Approach, International TraumaCare, European North Cape Cruise, June-July 2005.

51. Shock: Trauma: The Team Approach, International TraumaCare, European North Cape Cruise, June-July 2005.

52. Management of Hypertension in Trauma, Trauma: The Team Approach, International


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TraumaCare, European North Cape Cruise, June-July 2005. 53. The Role of Alpha-2 Agonists in TraumaCare: TraumaCare 2005, 18th Annual Trauma and

Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005. 54. Essentials of Pediatric Cervical Spine Trauma Care: TraumaCare 2005, 18th Annual Trauma

and Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005. 55. Pediatric Trauma Session: Moderator: TraumaCare 2005, 18th Annual Trauma and Critical

Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005. 56. Neurotrauma Session: Moderator: TraumaCare 2005, 18th Annual Trauma and Critical Care

Symposium, in conjunction with Urgences 2005, Paris, France, May 2005. 57. Trauma Poster Session: Moderator and Panelist: TraumaCare 2005, 18th Annual Trauma

and Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005. 58. Pediatric Trauma Poster Session: Moderator and Panelist: TraumaCare 2005, 18th Annual

Trauma and Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005.

59. Airway Management in Trauma: Workshop, TraumaCare 2004, 17th Annual Trauma Anesthesia and Critical Care Symposium, Sydney, Australia, October 2004.

60. Alpha Agonists for Sedation for the Critically Injured Trauma Patient: TraumaCare 2004, 17th Annual Trauma Anesthesia and Critical care Symposium, Sydney, Australia, October 2004.

61. Pediatric Trauma Poster Session: Moderator and Panelist: TraumaCare 2004, 17th Annual Trauma Anesthesia and Critical care Symposium, Sydney, Australia, October 2004.

62. Current Concepts in Fluid and Blood Resuscitation in Trauma: Trauma: the Team Approach to the Clinical Challenges, International TraumaCare, Maui, Hawaii, October 2004.

63. Cardiovascular Physiology for Shock: Trauma: the Team Approach to the Clinical Challenges, International TraumaCare, Maui, Hawaii, October 2004.

64. Cervical Spine Management in Trauma: Trauma: the Team Approach to the Clinical Challenges, International TraumaCare, Maui, Hawaii, October 2004.

65. The PA Catheter: Physiologically: Trauma: the Team Approach to the Clinical Challenges, International TraumaCare, Maui, Hawaii, October 2004.

66. Precedex in Trauma: Trauma: the Team Approach to the Clinical Challenges, International TraumaCare, Maui, Hawaii, October 2004.

67. Current Concepts in Fluid and Blood Resuscitation in Trauma: Trauma: the Team Approach to the Clinical Challenges, International TraumaCare, Falmouth, Massachusetts, July 2004.

68. Brain Death and Organ Donation: Trauma: the Team Approach to the Clinical Challenges,


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International TraumaCare, Falmouth, Massachusetts, July 2004. 69. Precedex in Trauma: Trauma: the Team Approach to the Clinical Challenges, International

TraumaCare, Falmouth, Massachusetts, July 2004. 70. Drug Overdoses, Poisoning and Envenomations: Trauma: the Team Approach to the

Clinical Challenges, International TraumaCare, Falmouth, Massachusetts, July 2004. 71. The PA Catheter Made Physiologically Simple: Trauma: the Team Approach to the Clinical

Challenges, International TraumaCare, Falmouth, Massachusetts, July 2004. 72. Fear: Trauma: The Team Approach, International Trauma and Critical Care Society’s

Alaskan Explorer Lectures, International TraumaCare, August 2003. 73. Swan Ganz Made Simple: Trauma: The Team Approach, International Trauma and Critical

Care Society’s Alaskan Explorer Lectures, International TraumaCare, August 2003. 74. Hypertension in Trauma: Trauma: The Team Approach, International Trauma and Critical

Care Society’s Alaskan Explorer Lectures, August 2003. 75. Dexmedetomidine in Trauma: Trauma: The Team Approach, International Trauma and

Critical Care Society’s Alaskan Explorer Lectures, August 2003. 76. Overdoses, Poisonings and Envenomations: Trauma: The Team Approach, International

Trauma and Critical Care Society’s Alaskan Explorer Lectures, August 2003. 77. Traumatic Brain Injury: Trauma: The Team Approach, International Trauma and Critical

Care Society’s Alaskan Explorer Lectures, August 2003. 78. Shock: Trauma: The Team Approach, International Trauma and Critical Care Society’s

Alaskan Explorer Lectures, August 2003. 79. Fluid Management in Trauma: Trauma: The Team Approach, International Trauma and

Critical Care Society’s Alaskan Explorer Lectures, August 2003. 80. Sedation for the Critically Injured Trauma Patient: Precedex, a Novel Alternative:

Traumacare 2003, 16th Annual Trauma Anesthesia and Critical care Symposium, Dallas, May 2003.

81. Human Crisis Simulation for Rural Medical Education: Traumacare 2003, 16th Annual Trauma Anesthesia and Critical care Symposium, Dallas, May 2003.

82. The Safety and Efficacy of Precedex versus Propofol in the Traumatic Brain Injured Patient: Trauma and Resuscitation International Group for Experimentation and Research (TRIGER) Forum, Dallas, May 2003.

83. Trauma Sedation: Precedex: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Lectures,


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November 2002. 84. Shock: Trauma: The Team Approach to the Clinical Challenge, International Trauma

Anesthesia and Critical Care Society's Turks and Caicos Lectures, November 2002. 85. Cardiac Drugs: Hypotension: Trauma: The Team Approach to the Clinical Challenge,

International Trauma Anesthesia and Critical Care Society's Turks and Caicos Lectures, Northwest Anesthesia Seminars, November 2002.

86. Cardiac Drugs: Hypertension: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Lectures, November 2002.

87. Traumatic Brain Injury: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Lectures, 2002.

88. Innovations in Anesthesia: Dexmedetomidine: Pain and Anesthesiology Review, West Virginia State Society of Anesthesiologists' Annual Meeting, White Sulfur Springs, West Virginia, May 2002.

89. Traumatic Shock: World Congress for Critical Care, Sydney, Australia in October 2001. 90. Airway Management in the Trauma Patient: World Congress for Critical Care, Sydney,

Australia in October 2001. 91. Shock: Trauma: The Team Approach to the Clinical Challenge, International Trauma

Anesthesia and Critical Care Society's Mediterranean Cruise, August 2001. 92. Current Concepts in Fluid and Blood Resuscitation: Trauma: The Team Approach to the

Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise, August 2001.

93. Cardiac Drugs 1: Hypotension: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise, August 2001.

94. Cardiac Drugs 2: Hypertension: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise, August 2001.

95. PA Catheter Made Physiologically Simple: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise, August 2001.

96. Spinal Cord Injury and Traumatic Brain Injury: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean


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Cruise, August 2001. 97. Brain Death and Organ Donation: Trauma: The Team Approach to the Clinical Challenge,

International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise, August 2001.

98. Simulation in Trauma: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise, August 2001.

99. Drug Overdose, Poisonings, and Envenomations: Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Mediterranean Cruise, August 2001.

NATIONAL PRESENTATIONS AND INVITED LECTURES 1. Sedation and Anesthesia in Pediatric Trauma, Topics in Anesthesia: A. Webb Roberts

Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Lake Tahoe, February 2016

2. Current Concepts in Fluid Management, Topics in Anesthesia, Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Arlington Virginia, June 2016

3. Trauma and Burn Anesthesiology, Topics in Anesthesia, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Arlington Virginia, June 2016

4. Intranasal Dexmedetomidine and Midazolam: A Novel Sedation Technique for Infant Pulmonary Function Tests, Topics in Anesthesia, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Arlington Virginia, June 2016.

5. Innovations and Advances in Anesthesiology, Topics in Anesthesia: Emphasis on Trauma, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Arlington Virginia, June 2016

6. Sedation and Anesthesia in Pediatric Trauma, Topics in Anesthesia: Emphasis on Trauma. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Lake Tahoe, February 2016

7. Essentials in Pediatric Trauma Anesthesiology, Topics in Anesthesia: Emphasis on Trauma, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Lake Tahoe, February 2016


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8. Sudden Cardiac Death/Arrest/Cardiac Emergencies, Topics in Anesthesia: Emphasis on Trauma, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Lake Tahoe, February 2016

9. Dexmedetomidine in Pediatric Trauma Care, Topics in Anesthesia: Emphasis on Trauma, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Lake Tahoe, February 2016

10. PBLD: An Octogenarian with Abdominal Aortic Aneurysm and the Need for Electroconvulsive Shock Therapy, Topics in Anesthesia: Emphasis on Trauma, Northwest Anesthesia Seminars, Baylor Health Care System, A Webb Roberts Center for Continuing Medical Education, Lake Tahoe, Nevada, February 2016

11. Innovations and Advances in Anesthesiology, Topics in Anesthesia: Emphasis on Trauma, A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Lake Tahoe, February 2016

12. The Business of Anesthesiology: Contract Considerations, Topics in Anesthesia: Emphasis on Trauma, Northwest Anesthesia Seminars, Baylor Health Care System, A Webb Roberts Center for Continuing Medical Education, Lake Tahoe, Nevada, February 2016

13. Basic Topics in Anesthesiology: Neuromuscular Diseases Part 1 (recording): Focused Board Review, CMEinfo.com, Oakstone Publishing, A.D.A.M. Education, Ebix, Inc. Atlanta, Georgia, June 7, 2015.

14. Advanced Topics in Anesthesiology: Neuromuscular Diseases Part 2 (recording): Focused Board Review, CMEinfo.com, Oakstone Publishing, A.D.A.M. Education, Ebix, Inc. Atlanta, Georgia, June 7, 2015.

15. Incorporating Simulation into the ACGME’s Milestones Evaluation Process: Simulation Program, Safar Symposium, Pittsburgh, May 2014.

16. Anesthesiology for Trauma and Burns: The University of Pittsburgh’s Department of Anesthesiology Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, April 2012.

17. Anesthesiology for Trauma and Burns: The University of Pittsburgh’s Department of Anesthesiology Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, April 2011.

18. Pediatric Anesthesiology: The University of Pittsburgh’s Department of Anesthesiology Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, April 2010.

19. Pediatric Anesthesiology: The University of Pittsburgh’s Department of Anesthesiology


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Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, April 2009. 20. All Hazards Considerations for Personal Protection and Airway Management: Workshop,

American Society of Anesthesiologists Annual Meeting, San Francisco, October 2007. 21. The Business of Trauma Care, American Society of Anesthesiology Practice Management

Seminar, Phoenix, February 2007. 22. Essentials of Pediatric Trauma: Refresher Course Lecture, American Society of

Anesthesiologists Annual Meeting, Atlanta, October 2005. 23. Integration of the Human Patient Simulation into ACLS Curriculum: Society for Education in

Anesthesia/Society for Technology in Anesthesia Joint Conference, June 1999. 24. A Case Discussion of Laryngeal Mask Airway in Out of Operating Room Airway

Management: Harvard Combined Critical Care Review Course, Harvard University School of Medicine, Boston, April 1997.

NATIONALLY PRESENTED POSTERS 1. Intranasal Dexmedetomidine & Midazolam: A Novel Sedation Technique for Infant PFT,

Society for Pediatric Anesthesia, Phoenix, Arizona, March 2015. 2. Consumptive Coagulopathy and Epiglottis in an Infant with Kassabach Merritt Phenomenon:

Medically Challenging Case, American Society of Anesthesiologists Annual Meeting, Washington, D.C., October 2012.

3. Goldenhar Syndrome and the AirQ Intubating LMA: Medically Challenging Case, American Society of Anesthesiologists Annual Meeting, Washington, D.C., October 2012.

4. High Inspiratory EtCO2 Due to Internal Hole in Pediatric Single Limb-O Circuit: Medically Challenging Case, Society of Anesthesiologists Annual Meeting, Chicago, October 2011.

5. Cardiac Arrest during Neonatal Tracheostomy Secondary to Bronchospasm: Medically Challenging Case, American Society of Anesthesiologists Annual Meeting, Chicago, October 2011.

6. Urgent PICU Consult!: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010 .

7. 3 Week Old with Stickler Syndrome, CHD, s/p Release of Tongue Lip Adhesion, Desaturated in NICU on POD #8, with Subsequent Inability To Intubate or Ventilate: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010 .

8. 12 Month Old Undergoing a Living Donor Liver Transplant with Loss of EtCO2 and Inability


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To Ventilate Via ETT with an Obstructive Mucous Plug in the Endotracheal Tube: Cain J, Tuchman J, Cassara A, Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010.

9. A 14 mo Female with Pierre Robin Syndrome Presents for Cleft Palate Repair and Has Laryngospasm during Induction: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010 .

10. 12 yo with Aplastic Anemia and Pneumo-Hemothorax during Broviac Placement: 12 Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010

11. Perioperative Midodrine (alpha 1 Agonist) Considerations: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, San Diego, October 2010 .

12. Airway Compromise in Interventional Radiology Suite after Thrombin Injection for Vertebral Artery Pseudoaneurysm, Society for Pediatric Anesthesiology, San Antonio, April 2010.

13. Use of the LMA to Facilitate Ventilation of Patient with a Tracheostomy Tube: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

14. 7 year old boy with tracheostomy bleed: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

15. 6 year old tracheostomy dependent child with tracheostomy bleeding and respiratory distress tracheal secondary to tracheal compression from a vertebral pseudoaneurysm: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

16. An Octogenarian with Abdominal Aortic Aneurysm and the Need for Electroconvulsive Shock Therapy: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

17. An Octogenarian with Severe Cardiac Disease and a Difficult Airway: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

18. Effects of Dexmedetomidine on Epiglottic and Tongue Base Collapse: Society for Pediatric Anesthesia Annual Meeting, Jacksonville, Florida, March 2009.

19. The Trauma Patient: Lessons Learned from Iraq, the Middle East and Elsewhere: NYSSA 61st Post Graduate Assembly, New York, December 2007.

20. Remifentanil increases ECT seizure duration and improves Beck’s depression scores: Society for Electroconvulsive Therapy Annual Meeting, Chicago, May 2000.


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21. Remifentanil increases ECT seizure duration: American Society of Anesthesiology, Annual Meeting, Dallas, Texas, October 1999.

22. Remifentanil Increases ECT Seizure Duration and Improves Beck’s Depression Score’s Without Lowering Mini-mental Status Examinations: American Society of Anesthesiologists Annual Meeting, San Francisco, October 2000.

23. Remifentanil Decreases ECT Stimulus Required for Adequate Seizures: Society of Neuroanesthesia and Critical Care, October 2000.

24. Integration of the Human Patient Simulation into ACLS Curriculum: Society for Education in Anesthesia/Society for Technology in Anesthesia Joint Conference, June 1999.

25. A Case Discussion of Laryngeal Mask Airway in Out of Operating Room Airway Management: Harvard Combined Critical Care Review Course, Harvard University School of Medicine, Boston, April 1997.

STATE INVITED LECTURES AND PRESENTATIONS 1. The State of Anesthesia in West Virginia: West Virginia State Society of Anesthesiologists

Annual Meeting, Roanoke, West Virginia, May 2006. 2. Current Concepts in Fluid Management: West Virginia State Society of Anesthesiologists

Annual Meeting, White Sulfur Springs, West Virginia, May 2005. 3. The State of Anesthesia in West Virginia: West Virginia State Society of Anesthesiologists

Annual Meeting, White Sulfur Springs, West Virginia, May 2005. 4. Anesthesia for Bariatric Surgery: Rhode Island Society of Anesthesiologists 10th Annual

Meeting, Providence, Rhode Island, September 2004. 5. Traumatic Airway Injury in Octogenarian with Coronary Artery Disease and Cardiomyopathy:

Rhode Island Society of Anesthesiologists 10th Annual Meeting, Providence, Rhode Island, September 2004.

6. Trauma Critical Care, PBLD: Rhode Island Society of Anesthesiologists Annual Meeting, Providence, Rhode Island, September 2004.

7. Dexmedetomidine: A novel technique for difficult airway management: West Virginia State Society of Anesthesiologists Annual Scientific Meeting, White Sulfur Springs, West Virginia, May 2004.

8. Pulmonary artery catheters: swan or ugly duckling: West Virginia State Society of Anesthesiologists Annual Scientific Meeting, White Sulfur Springs, West Virginia, May 2004.

9. Alpha agonists: Novel techniques for sedation of the critically injured: Topics in Anesthesia


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and Trauma 2004, Community Medical Center’s Departments of Anesthesia and Trauma and the Department of Continuing Medical Education, Scranton Pennsylvania, April 2004.

10. The West Virginia Human Crisis Simulation Program: West Virginia State Society of Anesthesiologists Annual Scientific Meeting, White Sulfur Springs, West Virginia, May 2003.

11. Innovations in Anesthesia: Remifentanil: West Virginia State Society of Anesthesiology, White Sulfur Springs, West Virginia, May 2001.

12. Challenging cases in Anesthesia: Neuroanesthesia, Cardiac Anesthesia, and Pediatric Anesthesia, Panelist: West Virginia State Society of Anesthesiology, White Sulfur Springs, West Virginia, May 2001.

13. Cardiac Anesthesia: Off Pump Coronary Artery Bypass Surgery: Year 2000: State of the Art in Anesthesiology, Clinical Update on Anesthesiology, Pain Management, and Critical Care, West Virginia State Society of Anesthesiologists Annual Meeting, White Sulfur Springs, West Virginia, May 2000.

VISITING PROFESSOR 1. Pediatric Transplant Anesthesiology: Department of Anesthesiology, University of Virginia

School of Medicine, Charlottesville, May 2015 2. The State of Anesthesiology: Department of Anesthesiology, University of Tennessee

School of Medicine, Knoxville, April 2015 3. Pediatric Anesthesiology: Department of Anesthesiology, University of Tennessee School of

Medicine, Knoxville, April 2015 4. A Five Year Outlook: Anesthesiology, Acute and Critical Care Medicine, and Pain Medicine:

Executive Chalk Talk, St Jude Children’s Research Hospital, Memphis, Tennessee, March 2014.

5. The State of Anesthesiology: Division of Anesthesiology, St Jude Children’s Research Hospital, Memphis, Tennessee, January 2014.

6. Dexmedetomidine…unlabeled: Division of Anesthesiology, St Jude Children’s Research Hospital, Memphis, Tennessee, January 2014.

7. The State of Anesthesiology: Q&A Session, Texas Tech University at El Paso, Paul L. Foster School of Medicine, November 2013.

8. The State of Anesthesiology: Q & A Session, Howard University School of Medicine, Washington, DC, November 2013.

9. Dexmedetomidine Use in Pediatric Anesthesiology: Grand Rounds, Department of


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Anesthesiology, University of Virginia School of Medicine, Charlottesville, November 2010. 10. Essentials of Pediatric Trauma Anesthesiology: Grand Rounds, Department of

Anesthesiology, University of Virginia School of Medicine, Charlottesville, November 2010. 11. A Rational Approach to Ventilator Strategies: Resident Lecture Series, Department of

Anesthesiology, University of Virginia School of Medicine, Charlottesville, November 2010. 12. Alpha 2 Agonists: Novel techniques in Anesthesiology: Grand Rounds, Department of

Anesthesiology, West Virginia University School of Medicine, February 2009. 13. Alpha 2 Agonists in Trauma Surgery and Critical Care: Grand Rounds, Department of

Trauma Surgery, Memorial Regional Hospital, Hollywood, Florida, November 2007. 14. Alpha-2 Agonist: New Dimensions in Anesthesia and Critical Care Medicine: Medical

Education Presentation, Cleveland Clinic, Cleveland, Ohio, March 2005. 15. Dexmedetomidine: Cleveland Clinic Foundation, Abbott sponsored symposium, Cleveland,

August 2003 16. Careers in Medicine and the Match: University of New England College of Osteopathic

Medicine, October 1996. UNIVERSITY INVITED LECTURES AND PRESENTATIONS 1. Pediatric Anesthesiology: Resident Lecture Series, UPMC Department of

Otorhinolaryngology, University of Pittsburgh School of Medicine, May 2015. 2. Milestones: New Frontiers in Evaluation and Automation: 12th Annual Safar Symposium,

University of Pittsburgh School of Medicine, Pittsburgh, May 2014. 3. Invited Executive Panel Moderator and Speaker: Third Annual Katz-Echo Global R&D and

Collaboration Forum: Leading Organizations to Innovate Smarter, University of Pittsburgh Katz School of Business, Pittsburgh, January 2013.

4. The Benjamins: Global Executive Forum, University of Pittsburgh’s Katz School of Business, Pittsburgh, July 2012.

5. Strategic Management: UPMC Life Saving Medicine: University of Pittsburgh’s Katz School of Business, Pittsburgh, July 2012.

6. Lessons Learned: Creating a Point of View: Global Executive Forum, Katz Graduate School of Business, University of Pittsburgh, Sao Paolo, Brazil, March 2012.

7. Strategic Leadership: Global Executive Forum, Katz Graduate School of Business, University of Pittsburgh, Sao Paolo, Brazil, March 2012.

8. A Global Perspective of Product Launch: University of Pittsburgh’s Katz School of Business,


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December 2011. 9. Effect of Interpersonal Relationships on Ethical Decision Making: Global Executive Forum,

University of Pittsburgh’s Katz School of Business, Prague, Czech Republic, August 2011. 10. UPMC Suffers Rare Loss: The Effect of Mark to Market: University of Pittsburgh’s Katz

School of Business, April 2011. 11. Coach K and Coach Knight: A Comparison of Leadership Styles: University of Pittsburgh’s

Katz School of Business, March 2011. 12. Dexmedetomidine for Adults and Children: 10th Annual Summer Anesthesia Seminar,

University of Pittsburgh Nurse Anesthesia Program, June 2009. 13. Novel techniques in Pediatric Anesthesiology: Dexmedetomidine: Pediatric Anesthesia

Update, Pediatric Anesthesia Review Course, University of Pittsburgh School of Nursing, Nurse Anesthesia Program, November 2008.

14. An Introduction to Invasive Monitoring: Clinical skills course for second year medical students, West Virginia University School of Medicine, March 2001 (multiple sessions).

15. Interpretation of Pulmonary Artery Catheter Data: Clinical skills course for second year medical students, West Virginia University School of Medicine, March 2001 (multiple sessions).

16. Remifentanil: Nursing Grand Rounds, Monongalia General Hospital, September 2000. 17. Introduction to Ventilator Management: Fundamental Critical Care Support Course, Society

of Critical Care Medicine, Center for Rural Emergency Medicine, West Virginia University School of Medicine, September 2000 (multiple sessions).

18. An Introduction to Invasive Monitoring: Clinical skills course for second year medical students, West Virginia University School of Medicine, April 1999 (multiple sessions).

19. Interpretation of Pulmonary Artery Catheter Data: Clinical skills course for second year medical students, West Virginia University School of Medicine, April 1999 (multiple sessions).

20. Myocardial Ischemia and Infarction: Fundamental Critical Care Support Course, Society of Critical Care Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, March 1999.

21. Diagnosis and Management of Shock: Fundamental Critical Care Support Course, Society of Critical Care Medicine, West Virginia University School of Medicine, Morgantown, March 1999.

22. Pediatric and Adult Airway Management: Fundamental Critical Care Support Course,


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Society of Critical Care Medicine, Morgantown, March 1999 (multiple sessions). HOSPITAL INVITED LECTURES AND PRESENTATIONS 1. Sedation: Complications and Management (Session 2): Sedation Service Lecture Series,

Children’s Hospital of Pittsburgh of UPMC, November 2011. 2. Sedation: Complications and Management (Session 1): Sedation Service Lecture Series,

Children’s Hospital of Pittsburgh of UPMC, November 2011. 3. Safe Sedation and Contraindications to Sedation (Session 2): Sedation Service Lecture

Series, Children’s Hospital of Pittsburgh of UPMC, August 2011. 4. Safe Sedation and Contraindications to Sedation (Session 1): Sedation Service Lecture

Series, Children’s Hospital of Pittsburgh of UPMC, August 2011. 5. Dexmedetomidine for Sedation: Children’s Hospital of Pittsburgh of UPMC, Sedation Group,

University of Pittsburgh, February 2010. 6. Precedex: Patient Care Council, Monongalia General Hospital, Morgantown, West Virginia,

July 2001. 7. Remifentanil: Nursing Grand Rounds, Monongalia General Hospital, September 2000. DEPARTMENTAL INVITED LECTURES AND PRESENTATIONS 1. Pediatric Trauma Anesthesiology: Resident Lecture Series, Children’s Hospital of Pittsburgh

of UPMC, Department of Anesthesiology, University of Pittsburgh, May 2016. 2. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC,

Department of Anesthesiology, University of Pittsburgh, May 2016. 3. Contracting: Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department

of Anesthesiology, University of Pittsburgh, December 2015. 4. Life after Fellowship: Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC,

Department of Anesthesiology, University of Pittsburgh, December 2015. 5. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC,

Department of Anesthesiology, University of Pittsburgh, October 2015. 6. Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of

UPMC, Department of Anesthesiology, University of Pittsburgh, September 2015. 7. Ventilators: PGY2 Resident Lecture Series, UPMC Anesthesiology Residency Program,

September 2015. 8. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC,


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Department of Anesthesiology, University of Pittsburgh, July 2015. 9. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC,

Department of Anesthesiology, University of Pittsburgh, June 2015. 10. Contracting: Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department

of Anesthesiology, University of Pittsburgh, January 2015. 11. Life after Fellowship: Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC,

Department of Anesthesiology, University of Pittsburgh, November 2014. 12. Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of

UPMC, Department of Anesthesiology, University of Pittsburgh, September 2014. 13. Ventilators: PGY2 Resident Lecture Series, UPMC Anesthesiology Residency Program,

September 2014. 14. Mechanical Ventilation in in Pediatric Anesthesiology and Critical Care: Resident Lecture

Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2014.

15. Ventilator Strategies in Pediatric Anesthesiology and Critical Care: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, June 2014.

16. The Business of Anesthesiology: Contract Considerations: Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, February 2014.

17. Anesthetic Considerations and Management of Jehovah’s Witness Posterior Spine Surgery Patient with von Willibrand’s Disease: QA Conference, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, January 2014.

18. A Review of Pediatric Trauma: QA Conference, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, November 2013.

19. The Business of Anesthesiology: Life after Fellowship: Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, October 2013.

20. Difficult Airway Management: Resident Workshop, UPMC Anesthesiology Residency Program, Peter Winter Institute for Education and Simulation (WISER), University of Pittsburgh, October 2013.

21. Fiberoptic Bronchoscopy: Resident Workshop, UPMC Anesthesiology Residency Program, Peter Winter Institute for Education and Simulation (WISER), University of Pittsburgh,


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64

October 2013. 22. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC,

Department of Anesthesiology, University of Pittsburgh, October 2013. 23. Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of

UPMC, Department of Anesthesiology, University of Pittsburgh, September 2013. 24. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC,

Department of Anesthesiology, University of Pittsburgh, July 2013. 25. Advanced Difficult Airway Management: Resident Workshop, UPMC Anesthesiology

Residency Program, Peter Winter Institute for Education and Simulation (WISER), University of Pittsburgh, May 2013.

26. Dexmedetomidine: A Review: Pediatric Anesthesiology Board Review Couse, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, April 2013.

27. Acute Hypotension and Decreased Pulmonary Compliance: QA Conference, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, February 2013.

28. The Business of Anesthesiology: Life after Fellowship (Part 2): Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, January 2013.

29. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, January 2013.

30. Interviews and Contracting: Life after Fellowship: Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, October 2012.

31. Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2012.

32. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, October 2012.

33. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, June 2012.

34. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, April 2012.

35. Trauma and Burn Anesthesiology: University of Pittsburgh’s Department of Anesthesiology


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65

Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, March 2012. 36. The Business of Anesthesiology: Life after Fellowship (Part 2): Fellows Lecture Series,

Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, January 2012.

37. The Business of Anesthesiology: Life after Fellowship (Part 1): Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, October 2011.


39. Fundamental Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2011.

40. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, July 2011.

41. Fundamental Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, May 2011.


43. Essentials of Trauma and Burn Anesthesiology: University of Pittsburgh’s Department of Anesthesiology Annual Anesthesiology Board Review Course, Pittsburgh, Pennsylvania, March 2011.



46. The Business of Anesthesiology: Life (and Death) after Fellowship: Fellows Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2010.


48. Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, November 2009.

49. Ventilator Strategies in Pediatric Anesthesiology and Critical Care: Resident Lecture Series,


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66

Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, August 2009.

50. Surgical Complications of Broviac Placement: QA Conference, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, July 2009.



53. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, March 2009.

54. Dexmedetomidine: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, December 2008.

55. Considerations in Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2008.

56. Ventilator Strategies in Pediatric Anesthesiology and Critical Care: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2008.


58. Alpha 2 Agonists in Pediatric Anesthesiology: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, June 2008.

59. Ventilator Strategies in Pediatric Anesthesiology and Critical Care: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, February 2008.

60. Alpha 2 Agonists in Pediatric Anesthesiology: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, February 2008.

61. Ventilator Strategies in Pediatric Anesthesiology and Critical Care: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, November 2007.


CURRICULUM VITAE


67

62. Considerations in Pediatric Trauma Anesthesiology: Fellow Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2007.

63. Alpha 2 Agonists in Pediatric Anesthesiology: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2007.

64. Ventilator Strategies in Pediatric Anesthesiology: Resident Lecture Series, Children’s Hospital of Pittsburgh of UPMC, Department of Anesthesiology, University of Pittsburgh, September 2007.

65. Mechanical Ventilation in Infants: Resident Lecture Series, Children’s Hospital of Pittsburgh, University of Pittsburgh, September, 2006.

66. Essentials of Pediatric Trauma Anesthesia: Resident Lecture Series, Children’s Hospital of Pittsburgh, University of Pittsburgh, August 2006

67. Essentials of Pediatric Trauma Care: Grand Rounds, Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh, August 2006.

68. Dexmedetomidine and Remifentanil: New Kids on the Block: University of Pittsburgh’s Third Annual Postgraduate Anesthesia Conference, June 2006.

69. Mechanical Ventilation in Infants: Resident Lecture Series, Children’s Hospital of Pittsburgh, University of Pittsburgh, May 2006

70. Dexmedetomidine in pediatrics: Pediatric Anesthesia Update Symposium, Children’s Hospital of Pittsburgh Department of Anesthesiology, Journal Club, University of Pittsburgh, April 2006.

71. Mechanical Ventilation in Infants: Resident Lecture Series, Children’s Hospital of Pittsburgh, University of Pittsburgh, February 2006

72. Dexmedetomidine: Journal Club, University of Pittsburgh Department of Anesthesiology, Pittsburgh, Pennsylvania, February 2006.

73. Pediatric Cervical Spine Management in Trauma: Fellow Lecture Series, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, December 2005.

74. Mechanical Ventilation in Infants: Resident Lecture Series, Children’s Hospital of Pittsburgh, University of Pittsburgh, November 2005.

75. Dexmedetomidine: A Case Discussion: QA Meeting, Department of Anesthesia, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania,


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68

May 2005. 76. Neurotrauma: Pediatric Spinal Cord Injury: Fellow Lecture Series, Children’s Hospital of

Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, March 2005. 77. Trauma: Cervical Spine Management: Combined Grand Rounds, Departments of

Anesthesia, Trauma, and Radiology, Allegheny General Hospital, Pittsburgh, Pennsylvania, September 2004.

78. Dexmedetomidine for Anesthesia and Critical Care: Grand Rounds, Department of Anesthesia, West Virginia University, August 2003.

79. Pulmonary Arterial Catheter Interpretation: Critical Care Lecture Series, Department of Anesthesia, West Virginia University School of Medicine, May 2003

80. Innovations: Dexmedetomidine for Bariatric Surgery: Grand Rounds, Department of Anesthesia, Allegheny General Hospital, Pittsburgh, Pennsylvania, February 2003.

81. Communication in Anesthesia: Department of Anesthesiology Conference, Monongalia General Hospital, Morgantown, West Virginia, June 2001.

82. Introduction to Invasive Monitoring: Anesthesia Orientation Lectures, Department of Anesthesiology, West Virginia University School of Medicine, January 2001.

83. Anesthesia for ECT: Resident Lecture Series, Department of Anesthesiology, West Virginia University School of Medicine, January 2001.

84. Off Pump Coronary Artery Bypass Surgery: Grand Rounds, Department of Anesthesiology, West Virginia University School of Medicine, November 2000.

85. Pulmonary Artery Catheter Interpretation: Department of Anesthesiology, Resident Lecture Series, October 2000.

86. A Review of Pediatric Anesthesia: Anesthesia Grand Rounds, Monongalia General Hospital, July 2000.

87. An Introduction to Invasive Monitoring: Clinical skills course for second year medical students, West Virginia University School of Medicine, March 2000 (multiple sessions).

88. Interpretation of Pulmonary Artery Catheter Data: Clinical skills course for second year medical students, West Virginia University School of Medicine, March 2000 (multiple sessions).

89. Pediatric and Adult Airway Management: Fundamental Critical Care Support Course, Society of Critical Care Medicine, Center for Rural Emergency Medicine, West Virginia University School of Medicine, March 2000 (multiple sessions).

90. Pulmonary Artery Catheter Interpretation: Resident and medical student Critical Care


CURRICULUM VITAE


69

Medicine Lecture, Departments of Anesthesiology, Surgery and Emergency Medicine, West Virginia University School of Medicine, March 2000.

91. Pediatric Anesthesiology on Call: Grand Rounds, Department of Anesthesiology, West Virginia University School of Medicine, February 2000.

92. Pulmonary Artery Catheter Interpretation: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery and Emergency Medicine, West Virginia University School of Medicine, February 2000.

93. An Introduction to Pulmonary Artery Catheter: Resident and medical student Critical Care Medicine Lecture, Department of Pediatrics, West Virginia University School of Medicine, February 2000.

94. An Introduction to Pulmonary Artery Catheter: Resident and medical student Critical Care Medicine Lecture, Department of Pediatrics, West Virginia University School of Medicine, January 2000.

95. An Introduction to Ventilators: Resident and medical student Critical Care Medicine Lecture, Department of Pediatrics, West Virginia University School of Medicine, January 2000.

96. Basic Invasive Monitoring: Anesthesia Orientation Lectures, Department of Anesthesia, West Virginia University School of Medicine, Morgantown, West Virginia, January 2000.

97. An Introduction to Pulmonary Artery Catheter: Resident and medical student Critical Care Medicine Lecture, Department of Pediatrics, West Virginia University School of Medicine, December 1999.

98. An Introduction to Ventilators: Resident and medical student Critical Care Medicine Lecture, Department of Pediatrics, West Virginia University School of Medicine, December 1999.

99. An Introduction to Pulmonary Artery Catheter: Resident and medical student Critical Care Medicine Lecture, Department of Pediatrics, West Virginia University School of Medicine, November 1999.

100. An Introduction to Pulmonary Artery Catheter: Resident and medical student Critical Care Medicine Lecture, Department of Pediatrics, West Virginia University School of Medicine, October 1999.

101. Basic Invasive Monitoring: Anesthesia Orientation Lectures, Department of Anesthesia, West Virginia University School of Medicine, Morgantown, West Virginia, July, 1999.

102. Options for Invasive Monitoring: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery and Emergency Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, July, 1999.


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70

103. An Introduction to Pulmonary Artery Catheter Interpretation: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery and Emergency Medicine, West Virginia University School of Medicine, July 1999.

104. An Introduction to Airway Management in Critical Care Medicine: Fellow, resident and medical student Critical Care Medicine education lecture series, Departments of Anesthesiology, Surgery, Medicine, and Emergency Medicine, West Virginia University Hospitals, West Virginia University School of Medicine, June 1999.

105. An Introduction to Pulmonary Artery Catheter Interpretation: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery and Emergency Medicine, West Virginia University School of Medicine, May 1999.

106. An Introduction to Airway Management in Critical Care Medicine: Fellow, resident and medical student Critical Care Medicine education lecture series, Departments of Anesthesiology, Surgery, Medicine, and Emergency Medicine, West Virginia University Hospitals, West Virginia University School of Medicine, May 1999.

107. Cardiac Tamponade: Resident and staff lecture series, Section on Cardiovascular Anesthesia, Department of Anesthesiology, West Virginia University School of Medicine, May 1999.

108. Pacing and Automated Internal Cardioverter Defibrillators: Resident and staff lecture series, Section on Cardiovascular Anesthesia, Department of Anesthesiology, West Virginia University School of Medicine, May 1999.

109. An Introduction to Ventilator Management: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery, and Emergency Medicine, West Virginia University School of Medicine, April 1999.

110. An Introduction to Pulmonary Artery Catheter Interpretation: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery and Emergency Medicine, West Virginia University School of Medicine, April 1999.

111. An Introduction to Airway Management in Critical Care Medicine: Fellow, resident and medical student Critical Care Medicine education lecture series, Departments of Anesthesiology, Surgery, Medicine, and Emergency Medicine, West Virginia University Hospitals, West Virginia University School of Medicine, April 1999.

112. An Introduction to Airway Management in Critical Care Medicine: Fellow, resident and medical student Critical Care Medicine education lecture series, Departments of Anesthesiology, Surgery, Medicine, and Emergency Medicine, West Virginia University


CURRICULUM VITAE


71

Hospitals, West Virginia University School of Medicine, March 1999. 113. An Introduction to Ventilator Management: Resident and medical student Critical Care

Medicine Lecture, Departments of Anesthesiology, Surgery, and Emergency Medicine, West Virginia University School of Medicine, February 1999.

114. Ischemic Heart Disease: Resident and staff lecture series, Section on Cardiovascular Anesthesia, Department of Anesthesiology, West Virginia University School of Medicine, April 1999.

115. Perioperative Cardiac Risk: Journal Club, Department of Anesthesiology, West Virginia University School of Medicine, April 1999.

116. Acute Respiratory Distress Syndrome: Resident and staff lecture series, Section on Pulmonary Medicine, Department of Anesthesia, West Virginia University School of Medicine, March 1999.

117. An Introduction to Pulmonary Artery Catheter Interpretation: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery and Emergency Medicine, West Virginia University School of Medicine, February 1999.

118. An Introduction to Airway Management in Critical Care Medicine: Fellow, resident and medical student Critical Care Medicine education lecture series, Departments of Anesthesiology, Surgery, Medicine, and Emergency Medicine, West Virginia University Hospitals, West Virginia University School of Medicine, February 1999.

119. An Introduction to Pulmonary Artery Catheter Interpretation: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery and Emergency Medicine, West Virginia University School of Medicine, January 1999.

120. An Introduction to Ventilator Management: Resident and medical student Critical Care Medicine Lecture, Departments of Anesthesiology, Surgery, and Emergency Medicine, West Virginia University School of Medicine, January 1999.

121. Options for Invasive Monitoring: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, May 1998.

122. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, May 1998.

123. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General


CURRICULUM VITAE


72

Hospital, Harvard University School of Medicine, May 1998. 124. Options for Invasive Monitoring: Resident and medical student education lecture series,

Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, April 1998.

125. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, April 1998.

126. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, April 1998.

127. ACLS Algorithms: ACLS Course for Department of Anesthesia & Critical Care Faculty, Massachusetts General Hospital, Harvard University School of Medicine, March, 1998.

128. Options for Invasive Monitoring: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1998.

129. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1998.

130. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1998.

131. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1998.

132. Options for Invasive Monitoring: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, February 1998.

133. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, February 1998.

134. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, February 1998.


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73

135. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, February 1998.

136. Options for Invasive Monitoring: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, December 1997.

137. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, December 1997.

138. An Introduction to Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, November 1997.

139. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, November 1997.

140. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, November 1997.

141. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, November 1997.

142. Options for Invasive Monitoring: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, October 1997.

143. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine October 1997.

144. An Introduction to Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, September 1997.

145. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, September 1997.


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74

146. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, September 1997.

147. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, September 1997.

148. Introduction to Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, August 1997.

149. Options for Invasive Monitoring: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, August 1997.

150. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, August 1997.

151. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, August 1997.

152. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, August 1997.

153. An Introduction to the Use of the LMA in Trauma, Resuscitation and Intensive Care: Trauma Grand Rounds, Department of Surgery, Massachusetts General Hospital, Harvard University School of Medicine, July 1997.

154. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, July 1997.

155. An Introduction to Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, June 1997.

156. Options for Invasive Monitoring: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, June 1997.


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75

157. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, June 1997.

158. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, June 1997.

159. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, June 1997.

160. An Introduction to Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, May 1997.

161. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, May 1997.

162. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, May 1997.

163. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, May 1997.

164. Laryngeal Mask Airway in the Intensive Care Unit: Combined Grand Rounds: Department of Anesthesia & Critical Care and Department of Pulmonary Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, April 1997.

165. The Laryngeal Mask Airway in Trauma, Resuscitation, and Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, April 1997.

166. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, April 1997.

167. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, April 1997.


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76

168. An Introduction to Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1997.

169. Options for Invasive Monitoring: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1997.

170. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1997.

171. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, March 1997.

172. An Introduction to Critical Care: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, February 1997.

173. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, February 1997.

174. Pacing Options: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, February 1997.

175. Interpretation of Pulmonary Artery Catheter Information: Resident and medical student education lecture series, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, January 1997.

176. The Pulmonary Artery Catheter in Critical Care: Journal Club, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, February 1997.

177. Options for Monitoring Intra-operative Cardiac Ischemia: Journal Club, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, October 1996.

178. Cardiac surgical case discussion, a review of coronary anatomy: Grand Rounds, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, 1996.


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77

179. Hazards of Nitrous Oxide: Journal Club, Department of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard University School of Medicine, November 1993.

DEPARTMENTAL POSTER 1. Effects of Dexmedetomidine on Epiglottic and Tongue Base Collapse, Anesthesiology

Research Day, University of Pittsburgh Department of Anesthesiology, Pittsburgh, Pennsylvania, May 2009.

COMMUNITY AND OUTEREACH PRESENTATIONS AND INVITED LECTURES 1. The Harder I Work, The Luckier I Get: Lecture Series on Excellence, Port Jervis High

School, October 2015. COMMERCIAL INVITED LECTURES AND PRESENTATIONS 1. New Horizons: Alpha 2 Agonists: West Palm Beach, Florida, November 2007. 2. New Horizons: Alpha 2 Agonists: San Francisco, California, October 2007. 3. New Horizons: Alpha 2 Agonists: Mobile, Alabama, September 2007. 4. New Horizons: Alpha 2 Agonists: Chattanooga, Tennessee, September 2006. 5. New Horizons: Alpha 2 Agonists: Nashville, Tennessee, September 2006. RESEARCH AND RESEARCH RELATED ACTIVITIES Principle Investigator: Open-label evaluation of the population pharmacokinetic profile, safety, tolerability, and efficacy of tapentadol oral solution for the treatment of post-surgical pain in children aged from birth to less than 2 years, Grunenthal multicenter drug trial, $10,600/recruited patient, $2200/month for recruitment, $2800/screen failure, $10,000 startup and closeout, 2015-present. Principle Investigator: Physician Voice, Voice Aversion and Self-efficacy, IRB exempt, May 2015. Investigator: Prospective trial of intrathecal delivery of elaprase in patients with Hunter syndrome, 2013-present. Co- Principle Investigator: Intraosseous Access Utilization: Survey of Society for Pediatric Anesthesia Membership, 2010-2013. Investigator: Prospective trial of the incidence of tongue base collapse associated with the use of Dexmedetomidine in children, 2008-2013.


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Investigator: Prospective trial of the incidence of tachyarrhythmias associated with the use of Dexmedetomidine after cardiac surgery in children, 2006-2010. Investigator: Blood loss in craniofacial surgery: assessment of strategies to decrease transfusion, Children’s Hospital of Pittsburgh, University of Pittsburgh, 2006-2008. Investigator: Peri-operative adverse events in trisomy 21 patients, Children’s Hospital of Pittsburgh, University of Pittsburgh, 2006-2008. Co-principle Investigator: A hospital survey of obstetric practices in West Virginia, 2004-2007. Principle Investigator: A Prospective, Randomized, Trial Comparing the Impact of Continuous Thoracic Epidural Block to Intravenous Patient-Controlled Analgesia on Pain Control, Recovery and Quality of Life in Patients Undergoing Whipple Procedure for Pancreatic Cancer. 2004-2005. Investigator: Multicenter, double-blind, placebo controlled, randomized study of analgesic efficacy and safety of valdecoxib 20 mg QD and valdecoxib 20 mg BID compared to placebo over multiple days for management of acute post-surgical pain in patients undergoing ACL repair. 2004-2005. Grant from Pfizer. Investigator: ECLIPSE-SNP: Evaluation of CLEVELOX TM (clevidipine: IND no. 65,114) In the Perioperative Treatment of Hypertension Assessing Safety Events (with Sodium Nitroprusside as Active Comparator) Protocol No. TMC-CLV-03-04. Multicenter double blind study of 500 patients (adult men and women), 2004-2005. Principle Investigator: Correlation Between Perioperative Inspired Oxygen Content and Risk of Sternal Wound Infection in Cardiac Surgical Wound Infection in Cardiac Surgical Patients, West Virginia University IRB approved, MS-04-00, 2000-2005. Principle Investigator: Remifentanil for electroconvulsive therapy. West Virginia University IRB approved, 1998-2005. Investigator: Comparison of LMA pressures filled with water vs. air during nitrous anesthesia in pediatric patients. West Virginia University IRB approved, 2003-2004. Co-Principle Investigator: The Safety of Desflurane versus Isoflurane in Patients with Coronary Artery Disease Undergoing Peripheral Vascular Surgery. Phase IV, Multi-center, open-label, randomized, parallel comparison, active controlled study, IND #32,363, IRB, 2000-2002. Award $12,324.48 (Baxter Pharmaceutical Products, Inc.) Investigator: Post-operative Peripheral Brain Enzymes Levels. Kofke. W., Andrew, Sinz, Elizabeth, Cain, James, Vance, Robert, IRB, 2000-2001. Investigator: Evaluation of an Assessment Tool of Anesthesia Residents Using the Human


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Patient Simulator, Schwid, Howard, Sinz, Elizabeth, Rosen, Kathleen, Cain, James, Barbaccia, John, Kofke, W. Andrew, IRB, 2000-2001.. Investigator: Effects of Anesthesia and Prone Positioning on Blood Flow Velocity in the Ophthalmic Artery During Spine Surgery, Kofke, W. Andrew and Sinz, E., Cain, J., Barbaccia, J., Remalona, H., IRB # 14674, 2000-2001. Investigator: Remifentanil Effects on Blood Flow Velocity, Kofke, W. Andrew and Sinz, E., Cain, J., Barbaccia, J., Ahktar, N., West Virginia University IRB # 14475, 1999-2001. Principle Investigator: Cis-atricurium and vecuronium: cost saving through synergy, 1998. Principle Investigator: Comparison of vecuronium and cis-atricurium in the cardiac surgical patient, 1996-1998. Co-investigator: Nitric oxide use in cardiac surgical patients, 1997-1998. Investigator: Efficacy of sodium bicarbonate as an adjunct with varying doses of epinephrine in cardiac and cerebral resuscitation, 1991-1992. Principle Investigator: Effect of pre-mortem thrombolytic therapy on eye donor post enucleation complications, 1991-1992. Investigator: Aided investigation of benefits of sports drink compared with water, 1988. Principle Investigator: Undergraduate Senior Honors Program: Isolation of a previously undescribed protein associated with Lipoteichoic Acid in the cell wall of the Staphylococcus aureus, 1986-1987. Investigator: Comparison of wound healing among petroleum based ointments, 1986-1987. EXTERNAL SEMINARS AND INVITED LECTURESHIPS RELATED TO RESEARCH 1. Invited Plenary Session Speaker: 2nd International Conference & Exhibition on Orthopedics

and Rheumatology, Las Vegas 2013. 2. Invited Speaker: Current practices in fluid and blood component therapy in trauma, Session

515: Cardiac Trauma and Shock, the 4th International Congress of Cardiology, Guangzhou, China, December 2012.

3. Invited Speaker: New Strategies in Anesthesia and Perioperative Care, International Conference on Anesthesia and Perioperative Care, San Antonio, November 2012.

4. Invited Speaker: New Insights in the Field of Rheumatology, International Conference and Exhibition on Rheumatology & Therapeutics, Chicago, August 2012.

5. Dexmedetomidine in Pediatric Trauma Care: Pediatric Trauma Session, World Congress of Anesthesia, Buenos Aires, March 2012.


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6. Dexmedetomidine: Pediatric Airway Management: International Symposium on Pediatric Airway, Denver, Colorado, June 2011.

7. Dexmedetomidine Use in Pediatric Anesthesiology: Grand Rounds, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, November 2010.

8. Essentials of Pediatric Trauma Anesthesiology: Grand Rounds, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, November 2010.

9. An Octogenarian with Abdominal Aortic Aneurysm and the Need for Electroconvulsive Shock Therapy: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

10. An Octogenarian with Severe Cardiac Disease and a Difficult Airway: Medically Challenging Cases, American Society of Anesthesiologists Annual Meeting, New Orleans, October 2009.

11. Dexmedetomidine for Adults and Children: 10th Annual Summer Anesthesia Seminar, University of Pittsburgh Nurse Anesthesia Program, June 2009.

12. Effects of Dexmedetomidine on Epiglottic and Tongue Base Collapse: Society for Pediatric Anesthesia Annual Meeting, Jacksonville, Florida, March 2009.

13. Alpha 2 Agonists: Novel techniques in Anesthesiology: Grand Rounds, Department of Anesthesiology, West Virginia University School of Medicine, February 2009.

14. Novel techniques in Pediatric Anesthesiology: Dexmedetomidine: Pediatric Anesthesia Update, Pediatric Anesthesia Review Course, University of Pittsburgh School of Nursing, Nurse Anesthesia Program, November 2008.

15. The ITACCS annual invitation lecture: Alpha 2 Agonists in Trauma: ITACCS 2008 Cochin, 12th Annual Conference of International Trauma Anaesthesia & Critical Care Society, Indian Chapter, Cochin India, August 2008.

16. Sedation and Analgesia in Pediatric Trauma: TraumaCare 2008 Program, 21st Annual Trauma and Critical Care Symposium, International Trauma Care, Yokohama Japan, June 2008.

17. Alpha 2 Agonists in Trauma Surgery and Critical Care: Grand Rounds, Department of Trauma Surgery, Memorial Regional Hospital, Hollywood, Florida, November 2007.

18. All Hazards Considerations for Personal Protection and Airway Management: Workshop, American Society of Anesthesiologists Annual Meeting, San Francisco, October 2007.

19. Alpha 2 Agonists in Trauma Care: TraumaCare 2007 Program, 20th Annual Trauma and Critical Care Symposium, International Trauma Care, Las Vegas, May 2007.

20. Dexmedetomidine in Trauma Care: TraumaCare 2006 Program, 19th Annual Trauma and


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Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Santiago, Chile, September 2006.

21. TraumaCare: Buenos Aires Anesthesia Society, Buenos Aires, Argentina, September 2006. 22. Dexmedetomidine and Remifentanil: New Kids on the Block: University of Pittsburgh’s Third

Annual Postgraduate Anesthesia Conference, June 2006. 23. Dexmedetomidine in Trauma: Trauma: The Team Approach to the Clinical Challenge,

Northwest Anesthesia Seminars, St. Kitts, West Indies, April 2006. 24. Dexmedetomidine in pediatrics: Pediatric Anesthesia Update Symposium, Children’s

Hospital of Pittsburgh Department of Anesthesiology, Journal Club, University of Pittsburgh, April 2006.

25. Sedación en cuidados críticos / Dexmedetomidina®: Manejo de la via aerea y ventilacion en la emergencia, Ateno Abierto de Anesthesia, Terapia Intensiva y Emergencia, Hospital Britannico de Buenos Aires, Argentina, February 2006.

26. Dexmedetomidine in Trauma: Trauma: The Team Approach to the Clinical Challenge, Northwest Anesthesia Seminars, South American Cruise, February 2006.

27. Essentials of Pediatric Trauma: Refresher Course Lecture, American Society of Anesthesiologists Annual Meeting, Atlanta, October 2005.

28. Dexmedetomidine in Trauma Sedation: Trauma: The Team Approach to the Clinical Challenge, International TraumaCare, Mediterranean Cruise, October 2005.

29. Dexmedetomidine in Trauma Sedation Management: Trauma: The Team Approach, International TraumaCare, European North Cape Cruise, June-July 2005.

30. The Role of Alpha-2 Agonists in TraumaCare: TraumaCare 2005, 18th Annual Trauma and Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005.

31. Pediatric Trauma Session: Moderator: TraumaCare 2005, 18th Annual Trauma and Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005.

32. Neurotrauma Session: Moderator: TraumaCare 2005, 18th Annual Trauma and Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005.

33. Trauma Poster Session: Moderator and Panelist: TraumaCare 2005, 18th Annual Trauma and Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005.

34. Pediatric Trauma Poster Session: Moderator and Panelist: TraumaCare 2005, 18th Annual Trauma and Critical Care Symposium, in conjunction with Urgences 2005, Paris, France, May 2005.

35. Alpha-2 Agonist: New Dimensions in Anesthesia and Critical Care Medicine: Medical


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Education Presentation, Cleveland Clinic, Cleveland, Ohio, March 2005. 36. Airway Management in Trauma: Workshop, TraumaCare 2004, 17th Annual Trauma

Anesthesia and Critical care Symposium, Sydney, Australia, October 2004. 37. Alpha Agonists for Sedation for the Critically Injured Trauma Patient: TraumaCare 2004, 17th

Annual Trauma Anesthesia and Critical care Symposium, Sydney, Australia, October 2004. 38. Pediatric Trauma Poster Session: Moderator and Panelist: TraumaCare 2004, 17th Annual

Trauma Anesthesia and Critical care Symposium, Sydney, Australia, October 2004. 39. Precedex in Trauma: Trauma: the Team Approach to the Clinical Challenges, Maui, Hawaii,

October 2004. 40. Anesthesia for Bariatric Surgery: Rhode Island Society of Anesthesiologists 10th Annual

Meeting, Providence, Rhode Island, September 2004. 41. Traumatic Airway Injury in Octogenarian with Coronary Artery Disease and Cardiomyopathy:

Rhode Island Society of Anesthesiologists 10th Annual Meeting, Providence, Rhode Island, September 2004.

42. Trauma Critical Care, PBLD: Rhode Island Society of Anesthesiologists Annual Meeting, Providence, Rhode Island, September 2004.

43. Precedex in Trauma: Trauma: the Team Approach to the Clinical Challenges, Falmouth, Massachusetts, July 2004.

44. Dexmedetomidine: A novel technique for difficult airway management: West Virginia State Society of Anesthesiologists Annual Scientific Meeting, White Sulfur Springs, West Virginia, May 2004.

45. Alpha agonists: Novel techniques for sedation of the critically injured: Topics in Anesthesia and Trauma 2004, Community Medical Center’s Departments of Anesthesia and Trauma and the Department of Continuing Medical Education, Scranton Pennsylvania, April 2004.

46. Dexmedetomidine in Trauma: Trauma: The Team Approach, International Trauma and Critical Care Society’s Alaskan Explorer Lectures, Northwest Anesthesia Seminars, August 2003.

47. Dexmedetomidine: Cleveland Clinic Foundation, Abbott sponsored symposium, Cleveland, August 2003.

48. Dexmedetomidine for Anesthesia and Critical Care: Grand Rounds, Department of Anesthesia, West Virginia University, August 2003.

49. Sedation for the Critically Injured Trauma Patient: Precedex, a Novel Alternative: Traumacare 2003, 16th Annual Trauma Anesthesia and Critical care Symposium, Dallas,


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May 2003. 50. The Safety and Efficacy of Precedex versus Propofol in the Traumatic Brain Injured Patient:

Trauma and Resuscitation International Group for Experimentation and Research (TRIGER) Forum, Dallas, May 2003.

51. Innovations: Dexmedetomidine for Bariatric Surgery: Grand Rounds, Department of Anesthesia, Allegheny General Hospital, Pittsburgh, Pennsylvania, February 2003.

52. Trauma Sedation: Precedex, Trauma: The Team Approach to the Clinical Challenge, International Trauma Anesthesia and Critical Care Society's Turks and Caicos Lectures, Northwest Anesthesia Seminars, November 2002.

53. Innovations in Anesthesia: Dexmedetomidine, Pain and Anesthesiology Review, West Virginia State Society of Anesthesiologists' Annual Meeting, White Sulfur Springs, West Virginia, May 2002.

54. Airway Management in the Trauma Patient: World Congress for Critical Care, Sydney, Australia in October 2001.

55. Innovations in Anesthesia: Remifentanil: West Virginia State Society of Anesthesiology, White Sulfur Springs, West Virginia, May 2001.

56. Challenging cases in Anesthesia: Neuroanesthesia, Cardiac Anesthesia, and Pediatric Anesthesia, Panelist: West Virginia State Society of Anesthesiology, White Sulfur Springs, West Virginia, May 2001.

57. Anesthesia for ECT: Resident Lecture Series, Department of Anesthesiology, West Virginia University School of Medicine, January 2001.

58. Remifentanil Increases ECT Seizure Duration and Improves Beck’s Depression Score’s Without Lowering Mini-mental Status Examinations: American Society of Anesthesiologists Annual Meeting, San Francisco, October 2000.

59. Remifentanil Decreases ECT Stimulus Required for Adequate Seizures: Society of Neuroanesthesia and Critical Care, October 2000.

60. Remifentanil increases ECT seizure duration and improves Beck’s depression scores: Society for Electroconvulsive Therapy Annual Meeting, Chicago, May 2000.

61. Integration of the Human Patient Simulation into ACLS Curriculum: Society for Education in Anesthesia/Society for Technology in Anesthesia Joint Conference, June 1999.

OTHER RESEARCH RELATED ACTIVITIES EDITORSHIPS


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Editorial Board: Research in Medical Education, 2016-present. Section Editor: Anesthesia, Scholars Report, 2016-present. Editorial Board: Scholars Report, 2016-present. Editorial Board: SciTz Anesthesia: Clinical Research: http://scitechz.com/Anesthesia.html 2016-present. Editorial Board: Journal Medical & Clinical Research, 2016-present. Editorial Board: Journal of Anesthesia and Pain Management, 2014-present. Editorial Board: International Archives of Clinical Anesthesia Research (IACAR), 2014-present. Editorial Board: Journal of Pediatrics and Neonatal Care, 2014-present. Editorial Board: Anesthesia and Clinical Care, 2014-present. Editor: Symbiosis Open Journal of Anesthesiology and Pain Management, 2013-present. Editorial Board: Austin Journal of Anesthesia and Analgesia, 2013-present. Editorial Board: International Journal of Anesthesiology and Research, 2013-present. Editorial Board: WebmedCentral plus Anesthesiology, Specialty Editor, 2013-present. Editorial Board: Clinical Research on Foot and Ankle, 2012-present. Editorial Board: Open Journal of Anesthesiology, 2011-present. Editorial Board: Journal of Pain and Relief, 2011-present. Editorial Reviewer: Anesthesia and Analgesia, Impact Factor 2.321, 2008-present. Editor-in-Chief: TraumaCare, Journal of International TraumaCare, 2007-2009. Editorial Board: TraumaCare, OR and Intensive Care, 2001-2009 Guest Editor: TraumaCare, Volume 2 2006. JOURNAL REFEREEING Reviewer: Pediatric Blunt Trauma Guidelines, Guidelines Committee, Pediatric Trauma Society, 2012-present. Reviewer: Pediatric Preparedness Resource Kit, American Academy of Pediatrics, 2012-present. Reviewer: Ansethesia and Analgesia: (6 CME hours), Effects of short-term propofol and dexmedetomidine on lung mechanics, histology, and biological markers in experimental obesity, July, September 2015. Reviewer: Anesthesia and Analgesia: (3 CME hours), Difficult airway management for 13 infants undergoing glossopexy, July 2015. Reviewer: Journal of Anesthesia and Pain Management: (9 CME hours), Sub-Fascial


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85

Continuous Local Anesthesia Dramatically Reduces Narcotic Medication Requirements But Does Not Change Length of Stay Following Laparo-Endoscopic Single Site Donor Nephrectomy, August, October, December 2014. Reviewer: Journal of Anesthesia and Pain Management: (9 CME hours), Sub-Fascial Continuous Local Anesthesia Dramatically Reduces Narcotic Medication Requirements But Does Not Change Length of Stay Following Laparo-Endoscopic Single Site Donor Nephrectomy, August, October, December 2014. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-13-00173, Dexmedetomidine or Propofol – which is better for sedation of the critically ill patient in the intensive care units: a meta-analysis, March 2013. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-12-01625, The Effect of Team Member Role on Learning and Stress during Advanced Cardiac Life Support Simulation Training: Being in the Hot Seat Matters, December 2012. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-12-00276, Severe Pediatric Blunt Trauma – Successful ROTEM – guided Hemostatic Therapy with Fibrinogen Concentrate and No Administration of Fresh Frozen Plasma or Platelets, March 2012 Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-12-00057, Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Capsase-1-dependent Pyroptosis in Murine 1774 Macrophage, February 2012. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-11-01349, The volatile anesthetic isoflurane prevents ventilator-induced lung injury via phospoinositide 3-kinase/AKT signaling in mice, August 2011. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-11-01087, Impairment of carotid artery blood flow by supraglottic airway use in swine model of cardiac arrest, July 2011. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-10-01209R1, Adenovirus-Delivered Angiopoietin1 Accelerates the Inflammation Resolution of Endotoxic Acute Lung Injury in Mice, November 2010. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-10-01209, Adenovirus-Delivered Angiopoietin1 Accelerates the Inflammation Resolution of Endotoxic Acute Lung Injury in Mice, August 2010. Reviewer Anesthesia and Analgesia: (3 CME hours), AA-D-10-00220, Impact of an exchange group of practice regarding the teaching of medical reasoning in situations of emergency delivered to anesthetist residents, February 2010.


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86

Reviewer: Abstract reviewer, International Anesthesia and Research Society Annual Meeting, 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-09-01978, Anesthesiology Critical Care Medicine: A Fellowship and Faculty Recruitment Program, December 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-09-02122, Association between year of residency training and multiple attempts at endotracheal intubation, December 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-09-01158R1, High-Fidelity Simulation Demonstrates the Influence of Anesthesiologists' Age and Years from Residency on Emergency Cricothyroidotomy Skills, December 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-09-01620, An Evaluation of Three Models for the Acquisition of Fiberoptic Dexterity Skills during Time-constrained Training, October 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript Number AA-D-09-01158, High-Fidelity Simulation Demonstrates the Influence of Anesthesiologists' Age and Years from Residency on Emergency Cricothyroidotomy Skills, August 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript Number: AA-D-08-01999R1, Complications in the Radiographic Confirmation of Armored Endotracheal Tube Placement, January 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript Number: AA-D-08-02266, Risk factors for postoperative mortality and morbidities in emergency surgeries: A pilot retrospective cohort study, January 2009. Reviewer Anesthesia and Analgesia: (3 CME hours) AA-D-08-01925, Intraosseous Infusions: A Review for the Anesthesiologist, December 2008. Reviewer: Abstract reviewer, TraumaCare 2008, International Trauma Anesthesia and Critical Care Society Annual Meeting, Yokohama, Japan 2008. Reviewer: Abstract reviewer, TraumaCare 2007, International Trauma Anesthesia and Critical Care Society Annual Meeting, Las Vegas 2007. Reviewer: Abstract reviewer, TraumaCare 2006, International Trauma Anesthesia and Critical Care Society Annual Meeting, Santiago, Chile, 2006. Guest Reviewer: Anesthesia & Analgesia, 2005. Reviewer: Abstract reviewer, TraumaCare 2005, International Trauma Anesthesia and Critical


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Care Society Annual Meeting, Paris, France 2005. Reviewer: Abstract reviewer, TraumaCare 2004, International Trauma Anesthesia and Critical Care Society Annual Meeting, Sydney, Australia 2004. Reviewer: Abstract reviewer, TraumaCare 2003, International Trauma Anesthesia and Critical Care Society Annual Meeting, Dallas 2003. STUDY SECTION MEMBERSHIPS Committee Member: International Committee for the Study and Development of Anesthesia in Morbid Obesity, 2004-present. Director: Trauma and Resuscitation International Group for Experimentation and Research (TRIGER), 2002-2009. Committee Member: Research Committee, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2001. EXTRAMURAL GRANT REVIEWING Director: Trauma and Resuscitation International Group for Experimentation and Research (TRIGER), 2002-2009. DATA SAFETY MONITORING BOARD Member: Hospira, 2010-2014. SPECIALTY BOARD MEMBERSHIPS AND ORGANIZING COMMITTEES Board Member: Wake Up Safe, 2012-present Member: Guidelines Committee, Pediatric Trauma Society, 2012-present. Member: Manthan Healthcare Panel, 2012-present. Past President: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2009-present. Board of Directors: Pennsylvania Society of Anesthesiology, 2007-present. Founding member: World Society for Bariatric Anesthesia, 2004-present. Organizing Committee: 2nd International Conference & Exhibition on Orthopedics and Rheumatology, Las Vegas 2013 Program Chair: Pediatric Trauma Anesthesiology, 15th Annual World Congress of Anesthesiology, Buenos Aires, 2012.


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Program Chair: Pediatric Cardiac Anesthesiology, 15th Annual World Congress of Anesthesiology, Buenos Aires, 2012. Program Chair: Trauma Anesthesiology Workshop, 15th Annual World Congress of Anesthesiology, Buenos Aires, 2012. President: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2005-2009. Board of Directors: European Trauma Course, 2008-2009. Associate Executive Director: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2002-2009. Board of Directors: International Trauma Anesthesia and Critical Care Society, International Trauma Care, Trauma Care International 2001-2009. Member: TraumaCare 2008 Steering Committee 2006-2008. Vice Chair-person: TraumaCare 2008 Program Committee 2006-2008. Chair: TraumaCare2007 Program (20 CME hours), 20th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Las Vegas, May 2007. Scientific and Educational Exhibitor: American Society of Anesthesiologists, Chicago, Illinois, October 2006. Board of Directors: TraumaCare 2006 Program, 19th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Santiago, Chile, September 2006. President-elect: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2004-2005. Vice President: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2003-2005. Consultant: National Ultiva Speakers Bureau, Abbott Laboratories, Miami, March 2001. Committee Member: National Committee for Educational Meetings, Society for Education in Anesthesia, 1999-2000. Consultant: National American Red Cross Medical Advisory Board Meeting regarding PLAS+SD (Pooled Plasma, Solvent/Detergent Treated), Washington, D.C., March, 1999. SCIENTIFIC AND EDUCATIONAL EXHIBITOR Scientific and Educational Exhibitor: New York State Society of Anesthesiologists Post Graduate Assembly, New York, New York, December 2008.


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Scientific and Educational Exhibitor: American Society of Anesthesiologists, Orlando, Florida, October 2008. Scientific and Educational Exhibitor: American Society of Anesthesiologists, San Francisco, California, October 2007. Scientific and Educational Exhibitor: American Society of Anesthesiologists, Atlanta, Georgia, October 2005. Scientific and Educational Exhibitor: American Society of Anesthesiologists, Las Vegas, Nevada, October 2004. Scientific and Educational Exhibitor: American Society of Anesthesiologists, San Francisco, California, October 2003. Scientific and Educational Exhibitor: American Society of Anesthesiologists, Orlando, Florida, October 2002. Scientific and Educational Exhibitor: American Society of Anesthesiologists, New Orleans, Louisiana, October 2001. Scientific and Educational Exhibitor: American Society of Anesthesiologists, San Francisco, California, October 2000. CURRENT RESEARCH INTERESTS Medical economics and management Dexmedetomidine Pediatric Anesthesiology

SERVICE

INTERNATIONAL SERVICE Past President: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2009-present. Founding member: World Society for Bariatric Anesthesia, 2004-present. Committee Member: International Committee for the Study and Development of Anesthesia in Morbid Obesity, 2004-present. Consultant: Development and Creation of Pediatric Transplant Program, Hospital Cardioinfantil, Bogota, Columbia, 2014-2015. Board of Directors: European Trauma Course, 2008-2009. President: International Trauma Anesthesia and Critical Care Society (ITACCS), International


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Trauma Care, Trauma Care International 2005-2009. Chair: Education and Training Committee, International Trauma Anesthesia and Critical Care Society, International Trauma Care, Trauma Care International 2003-2009. Director: Trauma and Resuscitation International Group for Experimentation and Research (TRIGER), 2002-2009. Associate Executive Director: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2002-2009. Committee Member: Critical Care Committee, International Trauma Anesthesia and Critical Care Society, International Trauma Care, Trauma Care International 2002-2009. Committee Member: Disaster and Mass Casualty Committee, International Trauma Anesthesia and Critical Care Society, International Trauma Care, Trauma Care International 2002-2009. Committee Member: Education and Training Committee, International Trauma Anesthesia and Critical Care Society, International Trauma Care, Trauma Care International 2002-2009. Board of Directors: International Trauma Anesthesia and Critical Care Society, International Trauma Care, Trauma Care International 2001-2009. Vice Chair-person: TraumaCare 2008 Program Committee 2006-2008. Member: TraumaCare 2008 Steering Committee 2006-2008. Chair: TraumaCare2007 Program (20 CME hours), 20th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Las Vegas, May 2007. Board of Directors: TraumaCare 2006 Program, 19th Annual Trauma and Critical Care Symposium, International Trauma Anesthesia and Critical Care Society, Santiago, Chile, September 2006. Co-Director: ACCME Recredentialing, International TraumaCare, 2005-2006. President-elect: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2004-2005. Vice President: International Trauma Anesthesia and Critical Care Society (ITACCS), International Trauma Care, Trauma Care International 2003-2005. NATIONAL SERVICE Committee Member: Committee on Access to Safe Pediatric Care, American Society of Anesthesiologists, 2015-present. Committee Member: Finance Committee, Wake Up Safe: The Pediatric Anesthesia Quality Improvement Initiative, 2015-present.


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Representative: Pennsylvania’s Representative to American Society of Anesthesiologists Medicare Contractor Advisory Committee, 2014-present. Representative: Pennsylvania’s Representative to Mid-Atlantic Medicare Contractor Advisory Committee, 2014-present. Delegate: Pennsylvania Society of Anesthesiology Alternate Delegate to the American Society of Anesthesiologists, 2013-present. Committee Member: Pediatric Anesthesia Liver and Intestinal Transplant Interest Group, 2013-present. Board of Directors: Wake Up Safe: The Pediatric Anesthesia Quality Improvement Initiative, 2012-present. Committee Member: American Society of Anesthesiologists Lifeline Advisory Council, 2009-present. Alternate Delegate: Pennsylvania Society of Anesthesiology Alternate Delegate to the American Society of Anesthesiologists, 2007-2012. Written Examination Question Writer: American Board of Anesthesiology, 2005. Oral Board Examiner: American Board of Anesthesiology, 2004-2005. Delegate: West Virginia Delegate to American Society of Anesthesiologists, 2003-2004. Delegate: West Virginia Delegate to American Society of Anesthesiologists, 2001-2002 Representative: West Virginia’s Representative to American Society of Anesthesiologists Medicare Contractor Advisory Committee, 2001-2002. Alternate Representative: West Virginia’s Representative to Mid-Atlantic Medicare Contractor Advisory Committee, 2001-2002. STATE SERVICE Founding Member: Finance Committee, Pennsylvania Society of Anesthesiology, 2012-present. Committee Member: Critical Care Medicine Committee, Pennsylvania Society of Anesthesiology, 2010-present. Past President: West Virginia State Society of Anesthesiologists, 2008-present. Board of Directors: Pennsylvania Society of Anesthesiology, 2007-present. Committee Member: Membership Committee, Pennsylvania Society of Anesthesiology, 2007-present. Honorary Member: West Virginia State Society of Anesthesiologists, 2006-present. Immediate Past President: West Virginia State Society of Anesthesiologists, 2006-2008.


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92

President: West Virginia State Society of Anesthesiologists, 2004-2006. Executive Committee: West Virginia Society of Anesthesiologists, 2002-2006. President-Elect: West Virginia State Society of Anesthesiologists, 2002-2004. Director: West Virginia State Society of Anesthesiologists Subcommittee on Anesthesiologist’s Assistants in West Virginia, 2001-2002. UNIVERSITY AND HEALTH SYSTEM SERVICE Consultant: Development and Creation of Pediatric Transplant Program, Collaborative Children’s Hospital of Pittsburgh of UPMC and University of Virginia Pediatric Liver Transplant Program, Charlottesville, Virginia, 2015-present. Committee Member: UPMC Systemwide Surgical Safety Initiative Committee, 2012-present. Committee Member: UPMC Systemwide Surgical Services Committee, 2011-present. Committee Member: West Virginia Crisis Simulator Center Committee, West Virginia University School of Medicine, 1998-2001. HOSPITAL SERVICE Committee Member: Liver Transplant Quality Council, Children’s Hospital of Pittsburgh, 2014-present. Committee Member: ENT/Perioperative Steering Workgroup, Children’s Hospital of Pittsburgh, 2013-present. Member: Physician Leadership Group, Children’s Hospital of Pittsburgh of UPMC, 2011-present. Committee Member: Perioperative Strategic Planning, Children’s Hospital of Pittsburgh, 2010-present. Committee Member: Perioperative Efficiency Task Force, Children’s Hospital of Pittsburgh, 2009-present. Committee Member: Perioperative Executive Committee, Children’s Hospital of Pittsburgh, 2008-present. Committee Member: Perioperative (formerly Operating Room) Steering Committee, Children’s Hospital of Pittsburgh, 2008-present. Anesthesiology Liaison: American College of Surgeons’ Level 1 Site Survey Group, Children’s Hospital of Pittsburgh, 2006-present. Committee Member: Medical Advisory Committee for Trauma, Children’s Hospital of Pittsburgh,


CURRICULUM VITAE


93

2005-present. Committee Member: Medical Executive Committee, Monongalia General Hospital, 2001-2003. Committee Member: Surgical Policy Committee, Monongalia General Hospital, 2001-2003. Committee Member: Medical Administration Committee, Monongalia General Hospital, 2001-2003. Committee Member: Peer Review Committee, Monongalia General Hospital, 2000-2003. Committee Member: Obstetrics Committee, Monongalia General Hospital, 2000-2003. Committee Member: Hospital Bylaws Committee, Monongalia General Hospital, 2001-2002. Committee Member: Surgical Policy Committee Sub-committee for Continuous Narcotic Infusions, Monongalia General Hospital, 2001-2002. Committee Member: Ethics Committee, Ruby Memorial Hospital, Chestnut Ridge Hospital, and West Virginia University Children’s Hospital, Robert C. Byrd Health Sciences Center of West Virginia University Hospitals, 1999-2001. Committee Member: Surgical Task Force, Monongalia General Hospital, 2000-2001. Committee Member: Transfusion Committee, Ruby Memorial Hospital and West Virginia University Children’s Hospital, Robert C. Byrd Health Sciences Center of West Virginia University Hospitals, 1999-2001.

Committee Member: Massive Transfusion Committee, Ruby Memorial Hospital and West Virginia University Children’s Hospital, Robert C. Byrd Health Sciences Center of West Virginia University Hospitals, 2000. Committee Member: Reduction Pneumoplasty Team, Ruby Memorial Hospital, Robert C. Byrd Health Sciences Center of West Virginia University Hospitals, 1999-2000. Committee Member: Cardiothoracic Surgery Provider Partnering Sub-Committee (Lungs), Ruby Memorial Hospital, Robert C. Byrd Health Sciences Center of West Virginia University Hospitals, 1999. Committee Member: Vascular Surgery Provider Partnering Team, Ruby Memorial Hospital, Robert C. Byrd Health Sciences Center of West Virginia University Hospitals, 1999. DEPARTMENTAL SERVICE Director: Pediatric Anesthesiology Transplant Team, Department of Anesthesiology, Children’s Hospital of Pittsburgh of UPMC, 2014-present. Founding Member: Pediatric Anesthesiology Radiology Team, Department of Anesthesiology, Children’s Hospital of Pittsburgh of UPMC, 2014-present.


CURRICULUM VITAE


94

Chair and Founding Member: Milestones Evaluation Committee, UPMC Anesthesiology Residency, 2011-present. Founding Member: Pediatric Anesthesiology Transplant Team, Department of Anesthesiology, Children’s Hospital of Pittsburgh of UPMC, 2012-present. Chair: Evaluation and Competency Committee, UPMC Anesthesiology Residency, 2011-present. Committee Member: Program Review Committee, UPMC Anesthesiology Residency, 2011-present. Committee Member: Resident Curriculum Committee, UPMC Anesthesiology Residency, 2011-present. Committee Member: Medical Student Curriculum Committee, Department of Anesthesiology, University of Pittsburgh, 2011-present. Committee Member: Resident Evaluation Committee, UPMC Anesthesiology Residency, 2011-present. Committee Member: Fellowship Curriculum Committee, Department of Anesthesiology, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh, 2008-present. Committee Member: Anesthesia for Spinal Fusion Working Group, Department of Anesthesiology, Children’s Hospital of Pittsburgh, 2008-2013. Committee Member: Pediatric Advanced Airway Management, Pediatric Anesthesiology Fellowship, Children’s Hospital of Pittsburgh, University of Pittsburgh Department of Anesthesiology, 2008-present. Committee Member: Resident Evaluation and Competency Committee, UPMC Anesthesiology Residency, 2007-present. Committee Member: Resident Education Committee, UPMC Anesthesiology Residency, 2007-present. Chair: Committee for Redevelopment of Faculty Incentive Plan, Department of Anesthesiology, Children’s Hospital of Pittsburgh, 2008-2013. Committee Member: Anesthesia for Spinal Fusion Working Group, Department of Anesthesiology, Children’s Hospital of Pittsburgh, 2008-2013. Director: Quality Assurance and Quality Control, Department of Anesthesia, Monongalia General Hospital, 2000-2003. Director: Policy and Procedures, Department of Anesthesia, Monongalia General Hospital, 2000-2003.


CURRICULUM VITAE


95

Chair: Resident Evaluation and Competency Committee, Department of Anesthesiology, West Virginia University School of Medicine, 2000-2001. Committee Member: Resident Evaluation and Competency Committee, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2001. Director: Chief Resident Selection Committee, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2001. Committee Member: Clinical Competency Committee, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2001. Committee Member: Research Committee, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2001. Committee Member: Education Committee, Department of Anesthesiology, West Virginia University School of Medicine, 1998-2001. Director: Quality Assurance, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2000. Director: Cardiac Anesthesia Fellowship, Department of Anesthesiology, West Virginia University School of Medicine, 1999-2000. Committee Member: Department of Anesthesiology Promotions and Tenure Committee, West Virginia University School of Medicine, 1998-2000. Liaison: Department of Anesthesiology Industrial Liaison, West Virginia University School of Medicine, 1998-1999. Director: Department of Anesthesia & Critical Care Journal Club, Massachusetts General Hospital, 1997-1998. Committee Member: Fellow Evaluation and Competency Committee, Department of Anesthesia & Critical Care, Massachusetts General Hospital, 1998 Committee Member: Department of Anesthesia & Critical Care Clinical Practices and Safety Committee, Massachusetts General Hospital, 1996-1998. Committee Member: Department of Anesthesia & Critical Care Clinical Practices and Safety Committee, Planning Subcommittee, Massachusetts General Hospital, 1998.

CONTINUING MEDICAL EDUCATION Topics in Anesthesia: Emphasis on Trauma: (11 CME hours) A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas and Northwest Anesthesia Seminars, Lake Tahoe, February 2016


CURRICULUM VITAE


96

American Society of Anesthesiologists: Annual meeting and review course, San Diego, October 2015. Society for Pediatric Anesthesia Annual Meeting: (7.25 CME hours) Annual meeting and review course, San Diego, October 2015. Society for Education in Anesthesia: (7.5 CME hours) Annual meeting and review course, San Diego, October 2015. Reviewer: Anesthesia and Analgesia: (6 CME hours), Effects of short-term propofol and dexmedetomidine on lung mechanics, histology, and biological markers in experimental obesity, July, September 2015. Reviewer: Anesthesia and Analgesia: (3 CME hours), Difficult airway management for 13 infants undergoing glossopexy, July 2015. Reviewer: Journal of Anesthesia and Pain Management: (9 CME hours), Sub-Fascial Continuous Local Anesthesia Dramatically Reduces Narcotic Medication Requirements But Does Not Change Length of Stay Following Laparo-Endoscopic Single Site Donor Nephrectomy, August, October, December 2014. Developing Competitive Grant Applications: Faculty Professional Development Series, Office of Academic Career Development, University of Pittsburgh Health Sciences, December 2014. Reviewer: Journal of Anesthesia and Pain Management: (9 CME hours), Sub-Fascial Continuous Local Anesthesia Dramatically Reduces Narcotic Medication Requirements But Does Not Change Length of Stay Following Laparo-Endoscopic Single Site Donor Nephrectomy, August, October, December 2014. American Society of Anesthesiologists: (42 CME hours (MOCA Patient Safety credits 14.25)) Annual meeting and review course, New Orleans, October 2014. Society for Pediatric Anesthesia Annual Meeting: (7.25 CME hours) Annual meeting and review course, New Orleans, October 2014. Society for Education in Anesthesia: (7.5 CME hours) Annual meeting, October 2014. Wake Up Safe: QA Root Cause Analysis Review Couse, Ft Lauderdale, March 2014. American Society of Anesthesiologists: (17.5 CME hours), Annual meeting and review course, San Francisco, October 2013. Intensive Review of Pediatric Anesthesia: (14 CME hours) Society for Pediatric Anesthesia, Chicago, August 2013. Society for Education in Anesthesia: (20 CME hours) Annual Spring Meeting May-June, 2013. Pediatric Anesthesiology Board Review Course: (9 CME hours) Department of Anesthesiology,


CURRICULUM VITAE


97

Children’s Hospital of Pittsburgh of UPMC, April 2013. Wake Up Safe: QA Root Cause Analysis Review Couse, Las Vegas, March 2013. Society for Pediatric Anesthesia Annual Meeting: (17.5 CME hours) Annual meeting and review course, Las Vegas, March 2013. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-13-00173, Dexmedetomidine or Propofol – which is better for sedation of the critically ill patient in the intensive care units: a meta-analysis, March 2013. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-12-01625, The Effect of Team Member Role on Learning and Stress during Advanced Cardiac Life Support Simulation Training: Being in the Hot Seat Matters, December 2012. American Society of Anesthesiologists: (42.5 CME hours), Annual meeting and review course, Washington, D.C., October 2012. International Assembly for Pediatric Anesthesia: (17 CME hours), Washington, D.C., October 2012. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-12-01115, Clinical benefits of dexmedetomidine versus propofol in adult intensive care unit patients: a systematic review of randomized clinical trials, August 2012. University of Pittsburgh Department of Anesthesiology Annual Residency Review: (7 CME hours) Farmington, Pennsylvania, April 2012. 15th WFSA World Congress of Anaesthesiologists: (27 CME hours), Buenos Aires, Argentina. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-12-00276, Severe Pediatric Blunt Trauma – Successful ROTEM – guided Hemostatic Therapy with Fibrinogen Concentrate and No Administration of Fresh Frozen Plasma or Platelets, March 2012 Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-12-00057, Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Capsase-1-dependent Pyroptosis in Murine 1774 Macrophage, February 2012. American Society of Anesthesiologists: (30 CME hours) Annual meeting and review course, Chicago, October 2011. Pennsylvania Society of Anesthesiologists Legislative Conference: Harrisburg, Pennsylvania, October 2011. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-11-01349, The volatile anesthetic isoflurane prevents ventilator-induced lung injury via phospoinositide 3-kinase/AKT signaling in mice, August 2011.


CURRICULUM VITAE


98

Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-11-01087, Impairment of carotid artery blood flow by supraglottic airway use in swine model of cardiac arrest, July 2011. American Society of Anesthesiologists Legislative Conference: (3 CME hours) Washington, D.C., May 2011. University of Pittsburgh Department of Anesthesiology Annual Residency Review: (7 CME hours) Farmington, Pennsylvania, March 2011. University of Pittsburgh Department of Anesthesiology Grand Rounds: University of Pittsburgh, Pittsburgh, Weekly, January 2005-present. QA Conference, Department of Anesthesiology, Children’s Hospital of Pittsburgh, University of Pittsburgh, Monthly, January 2005-present. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-10-01209R1, Adenovirus-Delivered Angiopoietin1 Accelerates the Inflammation Resolution of Endotoxic Acute Lung Injury in Mice, November 2010. American Society of Anesthesiologists: (CME hours) Annual meeting and review course, San Diego, October 2010. Society for Pediatric Anesthesia: (7 CME hours) Annual Meeting, San Diego, October 2010. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-10-01209, Adenovirus-Delivered Angiopoietin1 Accelerates the Inflammation Resolution of Endotoxic Acute Lung Injury in Mice, August 2010. University of Pittsburgh Department of Anesthesiology Residency Review: (7 CME hours), Farmington, Pennsylvania, March 2010. Reviewer Anesthesia and Analgesia: (3 CME hours), AA-D-10-00220, Impact of an exchange group of practice regarding the teaching of medical reasoning in situations of emergency delivered to anesthetist residents, February 2010. American Society Anesthesiologists: (33.5 CME hours) Annual meeting and review course, New Orleans, October 2009. Society for Pediatric Anesthesia: (7 CME hours) Annual Meeting, New Orleans, October 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-09-01978, Anesthesiology Critical Care Medicine: A Fellowship and Faculty Recruitment Program, December 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-09-02122, Association between year of residency training and multiple attempts at endotracheal intubation, December 2009.


CURRICULUM VITAE


99

Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-09-01158R1, High-Fidelity Simulation Demonstrates the Influence of Anesthesiologists' Age and Years from Residency on Emergency Cricothyroidotomy Skills, December 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript AA-D-09-01620, An Evaluation of Three Models for the Acquisition of Fiberoptic Dexterity Skills during Time-constrained Training, October 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript Number AA-D-09-01158, High-Fidelity Simulation Demonstrates the Influence of Anesthesiologists' Age and Years from Residency on Emergency Cricothyroidotomy Skills, August 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript Number: AA-D-08-01999R1, Complications in the Radiographic Confirmation of Armored Endotracheal Tube Placement, January 2009. Reviewer Anesthesia and Analgesia: (3 CME hours), Manuscript Number: AA-D-08-02266, Risk factors for postoperative mortality and morbidities in emergency surgeries: A pilot retrospective cohort study, January 2009. Reviewer Anesthesia and Analgesia: (3 CME hours) AA-D-08-01925, Intraosseous Infusions: A Review for the Anesthesiologist, December 2008. Society for Pediatric Anesthesia: (19 CME hours) Annual Meeting, Jacksonville, Florida, March 2009. American Society of Anesthesiologists: (33.5 CME hours) Annual meeting and review course, Orlando, Florida, October 2008. Society for Pediatric Anesthesia: (7 CME hours) Annual meeting and review course, Orlando, Florida, October 2008. ITACCS 2008 Cochin, 12th Annual Conference of International Trauma Anaesthesia & Critical Care Society, Indian Chapter, Cochin India, August 2008. TraumaCare 2008, 20th Annual Trauma Anesthesia and Critical Care Symposium: International Trauma Anesthesia and Critical Care Society, Yokohama Japan, June 2008. European Trauma Course Board of Directors Meeting: Brussels, March 2008. University of Pittsburgh Department of Anesthesiology Grand Rounds: Pittsburgh, Pennsylvania, weekly, 2006-present. Medical Advisory Committee for Trauma: Children’s Hospital of Pittsburgh, University of Pittsburgh, Monthly, May 2005-present. American Society of Anesthesiologists: (CME hours) Annual meeting and review course, San


CURRICULUM VITAE


100

Francisco, California, October 2007. West Virginia State Society of Anesthesiologists Annual Meeting: (7.5 CME hours) Roanoke, West Virginia, May 2007. TraumaCare 2007, 20th Annual Trauma Anesthesia and Critical Care Symposium: International Trauma Anesthesia and Critical Care Society, Las Vegas, May 2007. TraumaCare Foundation Board of Directors Meeting: Chicago, Illinois, October 2006. American Society of Anesthesiology: (CME hours) Annual meeting and review course, Chicago, Illinois, October 2006. International TraumaCare Board of Directors Meeting: Santiago, Chile, September 2006. TraumaCare 2006, 19th Annual Trauma Anesthesia and Critical Care Symposium: International Trauma Anesthesia and Critical Care Society, Santiago, Chile, September 2006. University of Pittsburgh’s Third Annual Postgraduate Anesthesia Conference: (7 CME hours) Pittsburgh, Pennsylvania, June 2006. West Virginia State Society of Anesthesiologists Annual Meeting: (7.5 CME hours) Roanoke, West Virginia, May 2006. American Society of Anesthesiologists Legislative Conference: Washington, D.C., May 2006. Trauma: The Team Approach to the Clinical Challenge: (20 CME hours) International TraumaCare, St. Kitts, West Indies, April 2006. Pediatric Anesthesia Update Symposium: (6.5 CME hours) Children’s Hospital of Pittsburgh Department of Anesthesiology, Journal Club, University of Pittsburgh, April 2006. Trauma: The Team Approach to the Clinical Challenge: (20 CME hours) International TraumaCare, South American Cruise, January-February 2006. American Society of Anesthesiologists: (CME hours) Annual meeting and review course, Atlanta, October 2005. American Board of Anesthesiology Board Examiner: (24 CME hours) San Francisco, September 2005. Trauma: The Team Approach to the Clinical Challenge: (20 CME hours) International TraumaCare, Mediterranean Cruise, October 2005. Trauma, The Team Approach: (20 CME hours) International TraumaCare Society, European North Cape Cruise, June-July 2005 Trauma Care 2004, 18th Annual Trauma Anesthesia and Critical Care Symposium: International Trauma Anesthesia and Critical Care Society, Paris, France, May 2005. West Virginia Society of Anesthesiologists: (7 CME hours) Annual Meeting, White Sulfur


CURRICULUM VITAE


101

Springs, West Virginia, May 2005. American Society of Anesthesiologists Practice Management Seminar: (20 CME hours), San Francisco, February 2005. The Inner Circle Wealth Strategies Forum: BFI Consulting AG (Zurich-Embatingen, Switzerland), Nassau, Bahamas, January 2005. Allegheny General Hospital Department of Anesthesia Grand Rounds: Pittsburgh, Pennsylvania February 2003-2005. West Virginia University School of Medicine Department of Anesthesiology Grand Rounds:, Morgantown, West Virginia, July 1998-March 2000, January 2003-2004. American Society of Anesthesiologists: (34 CME hours) Annual meeting and review course, Las Vegas, Nevada, October 2004. Trauma Care 2004, 17th Annual Trauma Anesthesia and Critical Care Symposium: International Trauma Anesthesia and Critical Care Society, Sydney, Australia, October 2004. Trauma, The Team Approach: (20 CME hours) International Trauma Anesthesia and Critical Care Society, Maui, October 2004 West Virginia Society of Anesthesiologists: (7.5 CME hours) Annual Meeting, White Sulfur Springs, West Virginia, May 2004. American Society of Anesthesiologists’ Leadership Spokesperson Training Program: one of thirty invited participants, Washington, D.C., May 2004. American Society of Anesthesiologists Legislative Conference: Washington, D.C., May 2004. American Society of Anesthesiologists: (28.5 CME hours) Annual meeting and review course, San Francisco, California, October 2003. International Trauma Anesthesia and Critical Care Society’s Board of Director’s Meeting: San Francisco, California, October 2003. Selective Decontamination of the GI Tract Improves ICU Outcome: (0.25 CME hours) Medscape, September 2003. The Team Approach to the Clinical Challenge: (20 CME hours) International Trauma Anesthesia and Critical Care Society, Alaska, August 2003. West Virginia Society of Anesthesiologists: (.75 CME hours) Annual Meeting, White Sulfur Springs, West Virginia, May 2003. Trauma Care 2003, 16th Annual Trauma Anesthesia and Critical Care Symposium: (20 CME hours), International Trauma Anesthesia and Critical Care Society, Dallas, May 2003. Human Participation Protections Educations Education for Research Teams: National Institutes


CURRICULUM VITAE


102

for Health (NIH), May 2003. Human Subjects Research Education: Institutional Review Board, Allegheny General Hospital, Pittsburgh, Pennsylvania 2003. Society of Maternal Fetal Medicine Annual Scientific Meeting and Review Course: (22.5 CME hours) Sam Francisco, California, February 2003 Auburn University/Southern Medical Association's Certificate in Business Administration Courses: (20 CME hours) 2001-2002. The Team Approach to the Clinical Challenge: (14 CME hours) International Trauma Anesthesia and Critical Care Society, Turks and Caicos, November 2002. American Society of Anesthesiologists: (45 CME hours) Annual meeting and review course, Orlando, Florida, October 2002. International Trauma Anesthesia and Critical Care Society’s Board of Director’s Meeting: Orlando, Florida, October 2002. West Virginia Society of Anesthesiologists: (10 CME hours) Annual Meeting, White Sulfur Springs, West Virginia, May 2002. Monongalia General Hospital Executive Retreat, Farmington, Pennsylvania, May 2002. American Society of Anesthesiologists: (45 CME hours) Annual meeting and review course, New Orleans, Louisiana, October 2001. Anesthesiology Medicare Carrier Advisory Committee: New Orleans, Louisiana, October 2001. Trauma: The Team Approach to the Clinical Challenge: (20 CME hours) International Trauma Anesthesia and Critical Care Society, Mediterranean Cruise, August 2001. West Virginia Society of Anesthesiologists: (10 CME hours) Annual Meeting, White Sulfur Springs, West Virginia, May 2001. National Ultiva Speakers Bureau Meeting: Abbott Laboratories, Miami, Florida, March 2001. West Virginia Society of Anesthesiologists: Mid-Winter Meeting, Charleston, West Virginia, February 2001. American Society of Anesthesiologists: (45 CME hours) Annual meeting and review course, San Francisco, California, October 2000. Society for Neuroanesthesia and Critical Care: Annual meeting and review, San Francisco, California, October 2000. Society for Pediatric Anesthesia: Annual meeting and review, San Francisco, California, October 2000. Fundamental Critical Care Support Course: Society of Critical Care Medicine, Center for Rural


CURRICULUM VITAE


103

Emergency Medicine, West Virginia University School of Medicine, September 2000. Fundamental Critical Care Support Course: Society of Critical Care Medicine, Center for Rural Emergency Medicine, West Virginia University School of Medicine, March 2000. Year 2000: State of the Art in Anesthesiology, Clinical Update on Anesthesiology, Pain Management, and Critical Care: (10 CME hours) West Virginia Society of Anesthesiologists Annual Meeting, White Sulfur Springs, West Virginia, May 2000. West Virginia University School of Medicine Critical Care Medicine Grand Rounds: Morgantown, West Virginia, monthly, January 1999-March 2000. Fundamental Critical Care Support Course: Society of Critical Care Medicine, Center for Rural Emergency Medicine, West Virginia University School of Medicine, March 2000. American Society of Anesthesiologists: (45 CME hours) Annual meeting and review course, Dallas, Texas, October 1999. Combined Critical Care Course: (34 CME hours) Society of Critical Care Medicine and American College of Chest Physicians, Orlando, Florida, August 1999. 2nd Annual Cardiothoracic Update: (20 CME hours) Duke University Cardiothoracic Anesthesiology, Hilton Head, South Carolina, June 1999. 1999 Spring Meeting: Simulation in Anesthesia Education - A Comprehensive Approach: Society for Education in Anesthesia and the University of Rochester Department of Anesthesiology, Rochester, New York, June 1999. National American Red Cross Medical Advisory Board Meeting regarding PLAS+SD (Pooled Plasma Solvent/Detergent Treated): Washington, D.C., March 1999. Fundamental Critical Care Support Course: Society of Critical Care Medicine, West Virginia University School of Medicine, March 1999. Massachusetts General Hospital Department of Anesthesia and Critical Care Grand Rounds: Harvard University School of Medicine, Boston, Massachusetts, weekly, November 1993-June 1998. Massachusetts General Hospital Combined Anesthesia and Pulmonary Medicine Critical Care Grand Rounds: Harvard University School of Medicine, monthly, January 1996-June 1998. Massachusetts General Hospital Department of Surgery Trauma Surgery Section Grand Rounds: Harvard University School of Medicine, weekly, January 1997-June 1998. Harvard Combined Critical Care Review Course: Harvard University School of Medicine, Cambridge, Massachusetts, April 1998. Harvard Combined Critical Care Review Course: Harvard University School of Medicine,


CURRICULUM VITAE


104

Cambridge, April 1997. Grand Rounds: Department of Anesthesia & Critical Care Medicine, Boston Children’s Hospital, Harvard University School of Medicine, weekly, February and March 1996, July and August 1995. Grand Rounds: Department of Anesthesia, Brigham and Women’s Hospital, Harvard University School of Medicine, weekly, June 1994. Grand Rounds: Department of Internal Medicine, Yale University School of Medicine, Yale-New Haven Hospital, weekly, June 1992-July 1993. References available upon request.


Exhibit B


Exhibit B Materials Considered

Exhibit No. Description

1001 U.S. Patent No. 8,455,527 to Priyanka Roychowdhury & Robert A.

Cedergren, issued June 4, 2013

1003 Declaration of Dr. Alpaslan Yaman

1004 U.S. Patent No. 4,544,664

1005 U.S. Patent No. 4,910,214

1006 U.S. Patent No. 6,716,867

1007 2010 Precedex™ Label

1015 Giorgi, I., et al., International Journal for Quality in Health Care, Vol. 22, No. 3, 170-178 (2010)

1017 Palmgren, European Journal of Pharmaceutics and Biopharmaceutics, June 29, 2006.

1020 Gerlach, A., et al., A new dosing protocol reduces dexmedetomidine-associated hypotension in critically ill surgical patients, Journal of Critical Care, Vol. 24, No. 4, 568-574 (2009)

1021 Dyck, et al., Anesthesiology 78:813-820 (1993)

1022 Scheinin, et al, Anesthesiology 78:1065-1075 (1993)

1023 Yuen, et al. Anesth Analg 105:374-380 (2007)

1024 Venn, et al. Anaesthesia 54:1136-1142 (1999)

1035 Cain, TraumaCare, July 2007, p. 5

1038 Anderson et al., Am. J. Health Syst. Pharm. 69:595-7 (2012)

1039 G. DiSilvio, M. Jacoby, D. Weiner, A. Broussard, P. Callahan, and J. Cain, “Intranasal Dexmedetomidine & Midazolam: A Novel Sedation Technique for Infant PFT,” Society for Pediatric Anesthesia, Phoenix, Arizona (March 2015)


1040 Neu et al., Crit. Care Med. 10:610-12 (1982)

1041 Potts et al., Pediatrics 113:59-62 (2004)

1042 Merry et al., Pediatric Anesthesia 21:743-753 (2011)

1043 Rodriguez-Gonzalez et al., J. Am. Med. Info. Assoc. 1:72-78 (2012)

1044 “Injectable medicines,” WHO Collaborating Centre for Pharmaceutical Pricing and Reimbursement Policies, http://whocc.goeg.at/Glossary/PreferredTerms

1047 U.S. Patent No. 8,242,158 to Priyanka Roychowdhury & Robert A. Cedergren, issued August 14, 2012

1048 U.S. Application No. 13/541,524

1049 Office Action Response, mailed Sept. 17, 2012, U.S. Application No. 13/541,524

1053 U.S. Patent No. 8,338,470

1054 U.S. Application No. 13/678,148

1061 TOBIAS 2007

1062 Martin E, Ramsay G, Mantz J, Sum-Ping STJ. The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med. 2003, 18:29-41.
