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CURRICULUM VITAE

DATE: October 1, 2018

NAME: Hieronim Jakubowski

PRESENT TITLE: Adjunct Professor

OFFICE ADDRESS: Department of Microbiology, Biochemistry & Molecular Genetics, ICPH, 225 Warren Street, Newark, NJ 70103

TELEPHONE NUMBER/E-MAIL ADDRESS: 973-972-8733, [email protected]

CITIZENSHIP: USA

EDUCATION:A. Undergraduate Graduate and Professional

Adam Mickiewicz University Poznań, PolandM.Sc., Physical Chemistry Date Awarded: June 19, 1969

B. Graduate and ProfessionalAgricultural University, Poznań, PolandPh.D., Biochemistry Date Awarded: November 20, 1974

Institute of Biochemistry and BiophysicsPolish Academy of SciencesWarsaw, Poland D.Sc., habilitation, Biochemistry Date Awarded: December 22, 1978

POSTGRADUATE TRAINING:A. Internship and Residencies

N/AB. Research Fellowships

FEBS FellowDepartment of Biophysical Chemistry Hanover Medical School, Hannover, GermanyBiophysical Chemistry4/82 - 7/82

EMBO FellowDepartment of Chemistry, Imperial College of Science and Technology, London, UK Biochemistry11/80 - 12/80

C. Postdoctoral AppointmentsUniversity of New Mexico School of Medicine, Albuquerque, NMBiochemistrySeptember 1975 – September 1976

ACADEMIC APPOINTMENTS:

Rutgers University, New Jersey Medical SchoolDepartment of Microbiology, Biochemistry & Molecular GeneticsAdjunct Professor, 07/2013 - present

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mailto:[email protected]

Institute of Bioorganic Chemistry, Poznań, PolandProfessor, 02/2002 – 09/2016

University of Life Sciences, Poznań, PolandProfessor, 9/2008 – present

UMDNJ-New Jersey Medical School, Newark, NJDepartment of Microbiology & Molecular GeneticsAdjunct Professor 7/2009 – 6/2013Associate Professor 7/1999 - 6/2009Adjunct Associate Professor 7/1991 - 6/1999Adjunct Assistant Professor 2/1984 - 6/1991

Agricultural University, Poznań, Poland1/1979 - 10/1987 Associate Professor (on leave 10/82 - 10/87)3/1975 - 12/1978 Assistant Professor11/1973 - 2/1975 Senior Research Assistant10/1969 - 10/1973 Research Assistant

OTHER EMPLOYMENT OR MAJOR VISITNG APPOINTMENTS: Department of Microbiology & Molecular GeneticsUMDNJ-New Jersey Medical School, Newark, NJVisiting Scientist/Associate, 11/1982 - 1/1984

Department of Biophysical Chemistry Hanover Medical School, Hannover, GermanyFEBS Fellow, Laboratory of Günther Maas, 4/1982 - 7/1982

Department of ChemistryImperial College of Science and Technology, London, UKEMBO Fellow, Laboratory of Alan Fersht, 11/1980 - 12/1980

HONORS AND AWARDS:

Interview for WRNJ radio, about the study on HTL as a predictor of heart attack, October 1, 2018 Scientific Merit Awards, Chancellor of University of Life Sciences, Poznań 2013, 2014, 2015Scientific Merit Awards, Chancellor of Lódź University, Lódź 2009, 2012Session Chair, Intl Conference of the Polish Physiological Society, Lublin, 2008Session Chair, 3rd Intl Conference on Paraoxonases, University of California, Los Angeles, 2008Session Chair, 6th Conference on Homocysteine Metabolism, Saarsbrücken, Germany, 2007Session Chair, 2nd Intl Conference on Paraoxonases, Hajdúszoboszló, Hungary, 2006 Session Chair, 4th Conference on Hyperhomocysteinemia, Saarsbrücken, Germany, 2005Organizer & Chair, Homocysteine Session, 16th Intl Congress, Polish Pharmacological Society,

Poznan, 2004Interview for The Scientist Magazine’s article The Strange World of PXTGase, 2003 Featured in The Scientist Magazine’s article ‘Homing on Homocysteine’ 2000Organizer & Chair, Homocysteine Session, 6th Intl Congress on Amino Acids, 1999Finalist, UMDNJ University Excellence Awards in Biomedical Research, 1997, 1999, 2001J. Parnas Award, Polish Biochemical Society, 1984Scientific Merit Award, Minister of Science, Higher Education & Technology, Poland, 1974, 1976 Teaching Award, Chancellor of Agricultural University, Poznań 1979, 1981Scientific Merit Awards of the Chancellor of Agricultural University, Poznań, 1974-75, 1977-82

Discovery of proofreading in vivo cited in major textbooks: 2004 B. Lewin, Genes VIII2003 D. Metzler, Biochemistry2001 B. Lewin, Genes VII 1997 B. Lewin, Genes VI 1997 G. Zubay, Biochemistry1994 B. Lewin, Genes V

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SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES:

SERVICE ON MAJOR COMMITTEES:A. International

Israel Science Foundation (2018)Croatian Science Foundation (2016)The Wellcome Trust/ DBT India Alliance, July 2015National Science Center, Poland (2012, 2013-2014, 2018)Polish Science Foundation (6/2011-present)Swiss National Science Foundation (2003, 2010)Poland-Norway Research Fund (3-19-08)French National Research Agency, PNRA Program (6-11-07), US-Israel Binational Science Foundation (2004)Scientific Council, Agricultural University, Poznań, 1979-1982Admissions Committee, Agricultural University, Poznań, 1979Genetics & Molecular Biology Committee, Polish Academy of Sciences, Poznań, Poland, 1975-1977

B. NationalMember, National Institutes of Health, Vascular Pathobiology Special Review

Committee ZRG1 VH-D O3 M4/2010 Member, National Institutes of Health, Special Emphasis Panel/Scientific

Review Group 2007/10 ZDK1 GRB-7, 7/2007

Member, National Institutes of Health, Special Study Section SSS-2, Biochemistry 4/2001, 11/2001

Member, Research Committee, American Heart Association Heritage Affiliate, 2005-2008

Member, American Heart Association, NEA 4 Peer Review Committee, Cell Transport & Metabolism/Immunology & Microbiology 1999-2004

Member, Scientific Advisory Committee on Nucleic Acids and Protein Synthesis, American Cancer Society, 1996

Reviewer for National Science Foundation, 2000-presentNational Institutes of Health, 1999-presentVeterans Administration, 2003US Army Research Office, 2006American Chemical Society, The Petrolium Research Fund, 2007

C. Medical School/UniversityAdmissions Committee Interviewer, 1989 – 1999

D. Editorial Boards

Intl Journal of Molecular Sciences, 2018 - presentAmino Acids (Springer), 2013 - presentBiotechnologia (Poznan), 2011 - presentActa Biochimica Polonica, 2010 - presentJournal of Alzheimer’s Disease, 2010, 2013-2016Intl Journal of Genomics, 2017 - presentJournal of Amino Acids, 2008 - 2017Biomedicine & Pharmacotherapy, 2003 - presentResearch Communications in Molecular Pathology & Pharmacology, 1996 - 2001

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E. Ad Hoc Reviewer

Acta Biochimica Polonica, Advances in Therapy, Amino Acids, Analytical Biochemistry, Analytical & Bioanalytical Chemistry, Analytical Chemistry, Annals of the Rheumatic Diseases, Annals of Epidemiology, Antioxidants & Redox Signaling, Atherosclerosis Thrombosis & Vascular Biology, Biochemistry, Biochemical Journal, Biochimica et Biophysica Acta, Biochemistry & Biophysics Reports, Bioconjugate Chemistry, Bioorganic & Medicinal Chemistry, Cell Biochemistry & Biophysics, Cell Biology & Toxicology, Cellular & Molecular Biology, Cellular and Molecular Medicine, Cellular & Molecular Life Sciences, Circulation, Chemical Science, Clinical Chemistry, Disease Markers, EBioMedicine, EMBO Journal, Endocrine, European Journal of Nutrition, FASEB Journal, FEBS Journal, FEBS Letters, Food Chemistry, Genes & Development, Intl Journal of Biochemistry & Cell Biology, Intl Journal of Medical Sciences, Journal of Alzheimer’s Disease, Journal of American Chemical Society, Journal of Bacteriology, Journal of Biological Chemistry, Journal of Biochemistry, Journal of Chromatography, Journal of Cellular Physiology, Journal of Cellular & Experimental Medicine, Journal of Electroanalytical Chemistry, Journal of Molecular Biology, Journal of Neuroscience Research, Journal of the Royal Society Interface, Journal of Thrombosis and Homeostasis, Kidney International, Life Sciences, Metabolic Brain Disease, Molecular Biology Reports, Molecular Psychiatry, Nature Communications, Nutrition, Pediatrics, Pharmacogenetics & Genomics, PlosONE, Proc Natl Acad Sci USA, Protein Engineering, Protein Science, Redox Reports, RNA Biology, Science, Thrombosis & Haemostasis, Transplantation, Translational Research.

SPONSORSHIP OF CANDIDATES FOR POSTGRADUATE DEGREE:

Paweł Skrzydlewski, Pozań University of Life Sciences, Feb 2018 - presentMałgorzata Kupc, Pozań University of Life Sciences, Feb 2018 - present Łukasz Witucki, Institute of Bioorganic Chemistry, Poznań, Feb 2016 - presentMarianna Sassek, Institute of Bioorganic Chemistry, Poznań, Sept 2014 – Aug 2018Olga Utyro, Institute of Bioorganic Chemistry, Poznan, Sept 2013 - presentJacek Wroblewski, Institute of Bioorganic Chemistry, Poznań, July 2013 - present Izabela Bielinska, Institute of Bioorganic Chemistry, Poznań, April 2013 - presentMarta Rusek, University of Medical Sciences, Lublin, April 2015Dorota Gurda, Institute of Bioorganic Chemistry, Poznań, 2013Jaonna Suszynska-Zajczyk, Institute of Bioorganic Chemistry, Poznań, 2013Kamila Borowczyk, Lódź University, Poland, 2012Marta Sikora, Institute of Bioorganic Chemistry, Poznań, 2010Jarosław Zimny, Agricultural University, Poznań, 2007Dan Sinsimer, New Jersey Medical School, NewarkJoanna Perła, Institute of Bioorganic Chemistry, Poznań, 2006Mariusz Lacinski, Medical Sciences University, Poznań, 2005 Gina Conforti, New Jersey Medical School, NewarkRon Rubin, New Jersey Medical School, Newark, 2003Quing Mei Wang, New Jersey Medical School, Newark, 1998Nan Zhang, New Jersey Medical School, Newark, 1996Wen Wu Gao, New Jersey Medical School, Newark, 1996Hae Yeong Kim, Albert Einstein College of Medicine, NY, 1994Sarah Colla, New Jersey Medical School, Newark, 1991Mumtaz Rojiani, New Jersey Medical School, Newark, 1989Elzbieta Szczesna-Skorupa, Institute of Biochemistry & Biophysics, Warsaw, 1981

SPONSORSHIP OF POSTDOCTORAL FELLOWS:

Kamila Borowczyk, Ph.D, July-Oct 2018Joanna Perła-Kajan, Ph.D., Dec 2007-Mar 2009Grażyna Chwatko, Ph.D., 2003-2004

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Rafał Głowacki, Ph.D., 2002-2003Barbara Domagala, Ph.D., 2003Anetta Undas, Ph.D., 2003Joanna Smol, Ph.D., 2002Andrzej Guranowski, Ph.D., Visiting Professor, 2002

TEACHING RESPONSIBILITIES: A. Lectures or Course Directorships

Institute of Bioorganic Chemistry, Poznan, Graduate course on Homocysteine in Protein Structure/Function and Human Disease, May 10-24, 2016

Jan Dlugosz University (JDU), Czestochowa, Graduate course on Correcting Errors in Protein Biosynthesis – Chemical Biology of Homocysteine, October – November 2014Institute of Bioorganic Chemistry, Poznan, Graduate course on Homocysteine in

Health and Disease, May 2011 University of Life Sciences, Poznan, Undergraduate course on Homocysteine in

Health and Disease, May 2009 Institute of Bioorganic Chemistry, Poznan, Graduate course on Decoding Genetic

Information in Protein Biosynthesis, March 2004UMDNJ-Graduate School of Biomedical Sciences, Newark, Course on the

Genetic Code, 2001-2006;UMDNJ-Graduate School of Biomedical Sciences, Mini-course on Accuracy of

Molecular Processes, 1991, 2000UMDNJ-New Jersey Medical School, Newark, Medical Microbiology Lab, 1999-2008Medical Student Problem Based Learning (PBL) courses, 1990-1992Rutgers University, Newark, NJ, Undergraduate Molecular Genetics course, 1986Agricultural University, Poznan, Undergraduate Biochemistry Lab, 1969-1982

B. Research TrainingPost Doctoral Fellows: name, dates (inclusive) of trainingKamila Borowczyk, Ph.D, July-Oct 2018Joanna Perła-Kajan, PhD, Dec 2007 - Mar 2009Grażyna Chwatko, PhD, 2003-2004Rafał Głowacki, PhD, 2002-2003Barbara Domagała, PhD, Jul - Dec 2003Anetta Undas, PhD, Jan – Jun 2003Joanna Smól, PhD, Apr – Jul 2002Andrzej Guranowski, PhD, Visiting Professor, Apr - Jul 2002

Pre Doctoral Students: Łukasz Witucki, MSc, Feb 2016 – present (Aug - Nov 2018 @ Rutgers)Marianna Sassek, MSc, Sep 2014 – Aug 2018Izabela Bielińska, MSc, Feb 2013-present (Aug - Nov 2017 @ Rutgers)Jacek Wróblewski, MSc, Aug 2013-present (Feb - Aug 2017 @ Rutgers)Olga Utyro, MSc, Sep 2013-present (Aug -Dec 2016 @ Rutgers)Monika Wyszczelska-Rokiel, MSc, Dec 2013 - June 2014 (@ Rutgers)Marta Rusek, MSc, Apr 2011 - Feb 2013 (@ UMDNJ)Sebastian Marciniak, MSc, Apr - Sep 2012 (@ UMDNJ)Kamila Borowczyk, MSc, Nov. 2009 - May 2011 (@ UMDNJ)Joanna Tisończyk, MSc, Mar - Sep 2009 (@ UMDNJ)Joanna Suszynska, MSc, Sep 2007 - Jun 2013 (Mar 2009 - Sep 2009 (@ Rutgers)Dorota Gurda, MSc, Sep 2007- Sep 2013Jarosław Zimny, MSc, 2005-2007 (2006 @ UMDNJ)Marta Sikora, MSc, 2004- 2010 (2008 @ UMDNJ)Joanna Perła, MSc, 2003-2006 (2003 @ UMDNJ)

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Mariusz Lacinski, MSc, 2001-2005Rebecca Taurog, BSc, 2004 (@UMDNJ)Sofia Spadavecchia, BSc, 2003 (@UMDNJ)Julie Augustin, (Master’s Program), BSc, 2002-2003 (@UMDNJ)Wen Wu Gao, MD, 1991-1996 (@UMDNJ)Hae Yeong Kim, BSc, 1991-1994 (@UMDNJ)John Sipley, BSc, 1988-1992 (@UMDNJ)Mumtaz Rojiani, BSc, 1985-1989 (@UMDNJ)

Other:Nicole Davis, High School Summer Apprentice Research Program, 1999 (@UMDNJ)Leticia Colon, High School Summer Apprentice Research Program, 2001 (@UMDNJ)Tia Manning, Pre-Med Summer Research Student, 2001 (@UMDNJ)

CLINICAL RESPONSIBILITIES: N/A

GRANT SUPPORT:A. Principal Investigator

1. NCN (Poland) 2016/23/B/NZ5/00573, Autoimmune Response, Fibrin Clot Lysis, Homocysteine, and Cardiovascular Outcomes, 7/2017-7/2020, $254,000.

2. AHA 17GRNT32910002, Homocysteine-thiolactone in Prognostication of Cardiovascular Disease Outcomes, 1/2017 – 12/2018, $154,000.

3. 2015 Rutgers BHI-RUN-NJIT Pilot Grants in Neuroscience. mTOR Signaling and Homocysteine in the Brain. 01/02/2016 – 12/31/2017, $40,000 (with R. Dobrowolski)

4. NCN (Poland) 2013/11/B/NZ1/00091, Mechanisms and consequences of homocysteine incorporation into protein in humans. 07/28/2014 – 07/27/2018, $380,000

5. NCN (Poland) 2013/09/B/NZ5/02794, Hyperhomocysteinemia and Thrombosis, 02/13/2014 – 12/12/2017, $330,000

6. NCN (Poland) 2012/07/B/NZ7/01178, Determinants of Homocysteine-thiolactone Excretion in Humans, 7/2013 – 6/2016, $195,000

7. AHA, 12GRNT9420014, Mechanism of Connective Tissue Deficiencies in Hyperhomocysteinemia. 1/2012 – 12/2015, $198,000.

8. NCN (Poland) 2011/01/B/NZ1/03417, Thrombotic Mechanisms in Human Cystathionine beta-Synthease deficiency, 12/2011 - 11/2014, $242,000.

9. AHA, 0855919D, The Role of Homocysteine Thiolactone in Athrerosclerosis, 7/08 – 6/13, $198,000

10. MNiSW (Poland), N401 065 32/1504, Changes in gene expression caused by protein N-homocysteinylation, 6/07 – 5/10, $98,000

11. MNiSW (Poland), N401 132 32/2670, The role of bleomycin hydrolase in homocysteine metabolism & toxicity in human cells, 6/07 – 5/09, $16,600

12. AHA, 0250229N, The Role of Protein N-Homocysteinylation In Atherosclerosis, 1/02 - 6/05, $214,500

13. NSF, MCB-0089984, Editing of Homocysteine by Aminoacyl-tRNA Synthetases, 4/01-12/04, $330,000

14. NRC, Twinning Program with Poland, 9/02-2/03, $15,000

15. NRC, COBASE Grants Program, 8/02-10/02, $7,000

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16. Foundation of UMDNJ, #22 02, Editing of Homocysteine by Aminoacyl-tRNA Synthetases, 7/01 - 6/02, $35,000



19. ACS, NP-904, Physiology of Proofreading by AA-tRNA Synthetases, 1/95-12/96, $180,000

20. Foundation of UMDNJ, #l7 90, Role of AppppA in Cell Growth and Metabolism, 7/89 - 6/90, $23,322

21. NIH (BRS-NJMS), 2S07RR05393, Role of AppppA in Cell Growth and Metabolism, 7/88 - 7/89, $11,990

22. Foundation of UMDNJ #14 86, Role of AppppA and Related Compounds in Cell Growth Regulation, 7/85 - 6/87, $25,155

B. Co-Investigator1. NIH, Ribosome-based Single Molecule Method to Acquire Sequence Data from

Genomes (Mandecki) 6/07 – 5/12, $1,672,2372. MNiSW (Poland), N204 053 32/1226, Quatification of N-homocysteinylated albumin

in human plasma by proteomics, 8/07 – 7/11, $83,000

C. Pending1. NIH R21

PUBLICATIONS:

A. Refereed Original Article in Journal 1. Borowczyk K, Piechocka J, Głowacki R, Dahr I, Midttun Ø, Tell G, Ueland PM,

Nygård O, Jakubowski H. Urinary Excretion of Homocysteine Thiolactone and the Risk of Acute Myocardial Infarction in Coronary Artery Disease Patients; the WENBIT trial. Journal of Internal Medicine 2018 [Epub ahead of print Sep 23].

2. Borowczyk K, Wróblewski J, Suliburska JM, Akahoshi N, Ishii I, Jakubowski H. Mutations in Homocysteine Metabolism Genes Increase N-Homocysteinylation and Keratin Damage in Mice. International Journal of Genomics 2018, accepted August 16.

3. Perła-Kaján J, Borowczyk K, Głowacki R, Nygård O, Jakubowski H. Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans. FASEB J. 2018 May 21:fj201800346R. doi: 10.1096/fj.201800346R. [Epub ahead of print]

4. Szulinska M, Kręgielska-NarożnaM, ŚwiątekJ, Styś P, Kuźniar-Kamińska B, Jakubowski H*, Walkowiak J, Bogdański P. Garlic extract favorably modifies markers of endothelial function in obese patients – randomized double blind placebo-controlled nutritional intervention. Biomedicine & Pharmacotherapy 2018 ;102:792-797. doi: 10.1016/j.biopha.2018.03.131.

5. Borowczyk K, Suliburska J, Jakubowski H. Demethylation of methionine and keratin damage in human hair. Amino Acids 2018;50:537-546. DOI 10.1007/s00726-018-2545-3.

6. Jakubowski H. Homocysteine Editing, Thioester Chemistry, Coenzyme A, and the Origin of Coded Peptide Synthesis. Life (Basel). 2017 Feb 9;7(1). doi: 10.3390/life7010006.

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7. Khoosheh Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R. The Amino Acid Metabolite Homocysteine Activates mTORC1 to Inhibit Autophagy and Form Abnormal Proteins in Human Neurons and Mice. FASEB J 2017; 31:598-609.

8. Perła-Kajan J, Utyro O, Rusek M, Malinowska A, Sitkiewicz E, Jakubowski H.N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities. FASEB J 2016;30:3810-3821.

9. Borowczyk K, Chwatko G, Kubalczyk P, Jakubowski H, Kubalska J, Głowacki R. Simultaneous Determination of Methionine and Homocysteine by on-column derivatization with o-phtaldialdehyde. Talanta 2016;161:917-924.

10. Szulińska M, Skrypnik D, Ratajczak M, Karolkiewicz J, Madry E, Musialik K, Walkowiak J, Jakubowski H*, Bogdański P. Effects of Endurance and Endurance-strength Exercise on Renal Function in Abdominally Obese Women with Renal Hyperfiltration: A Prospective Randomized Trial. Biomed Environ Sci. 2016 Oct;29(10):706-712.

11. Guzzo MB, Nguyen HT, Pham TH, Wyszczelska-Rokiel M, Jakubowski H, Wolff KA, Ogwang S, Timpona JL, Gogula S, Jacobs MR, Ruetz M, Kräutler B, Jacobsen DW, Zhang GF, Nguyen L. Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. PLoS Pathog. 2016;12(10):e1005949.

12. Jakubowski H, Quantification of urinary S- and N-homocysteinylated protein and homocysteine-thiolactone in mice. Analytical Biochemistry 2016; 508:118-123.

13. Skrypnik D, Ratajczak M, Karolkiewicz J, Mądry E, Pupek-Musialik D, Hansdorfer-Korzond R, Walkowiak J, Jakubowski H*, Bogdański P. Effects of endurance and endurance–strength exercise on biochemical parameters of liver function in women with abdominal obesity. Biomed Pharmacother 2016;80:1-7.

14. Jakubowski H. Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World. FEBS Lett. 2016;590:469-481.

15. Glowacki R, Stachniuk J, Borowczyk K, Jakubowski H. Quantification of homocysteine and cysteine by derivatization with pyridoxal 5'-phosphate and hydrophilic interaction liquid chromatography. Analytical Bioanalytical Chemistry 2016;408:1935-41.

16. Bogdański P, Suliburska J, Szulińska M, Sikora M, Walkowiak J, Jakubowski H. l-Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats. Biomed Pharmacother 2015;76:100-106

17. Gurda D, Handschuh L, Kotkowiak W, Jakubowski H. Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells. Amino Acids 2015 Jul;47(7): 319-39. Epub 2015 Mar 24.

18. Drabowicz J, Jakubowski H, Kudzin MH, Kudzin ZH. The nomenclature of 1-aminoalkylphosphonic acids and derivatives: evolution of the code system. Acta Biochim Pol 2015;62(1):139-50. Epub 2015 Mar 2.

19. Suszyńska-Zajczyk J, Jakubowski H. Paraoxonase 1 and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis. Acta Biochim Pol 2014;61(4):815-23. Epub 2014 Oct 28

20. Liu W, Kavaliauskas D, Schrader JM, Poruri K, Birkedal V, Goldman E, Jakubowski H, Mandecki W, Uhlenbeck OC, Knudsen CR, Goldman YE,

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Cooperman BS. Labeled EF-Tus for rapid kinetic studies of pre-translocation complex formation. ACS Chem Biol. 2014;9:2421-2431. Epub 2014 Aug 22.

21. Suszyńska-Zajczyk J, Sikora M, Jakubowski H. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease. Mol Genet Metab. 2014;113:200-206. Epub 2014 Jul 17.

22. Suliburska J, Bogdanski P, Jakubowski H. The influence of selected antihypertensive drugs on zinc, copper, and iron status in spontaneously hypertensive rats. Eur J Pharmacol. 2014;738:326-31. Epub 2014 Jun 11.

23. Suszyńska-Zajczyk J, Utyro O, Jakubowski H. Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease. Mol Genet Metab, 2014;112:339-46. Epub 2014 May 24.

24. Suszyńska-Zajczyk J, Wróblewski J, Utyro O, Luczak M, Marczak L, Jakubowski H. Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis. Amino Acids. 2014;46:1471-80. Epub 2014 Mar 16.

25. Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H. Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration. J Alzheimers Dis. 2014 ;42:247-260.

26. Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration. J Alzheimer’s Dis 2014; 40:713-26.

27. Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H. Identification of N-homocysteinylation sites in plasma proteins. Amino Acids 2014; 46:235-44. Epub 2013 Nov 30.

28. Cholewa JM, Wyszczelska-Rokiel M, Glowacki R, Jakubowski H, Matthews T, Wood R, Craig SA, Paolone V. Effects of betaine on body composition, performance, and homocysteine thiolactone. J Int Soc Sports Nutr. 2013;10:39.

29. Chudaev M, Poruri K, Goldman E, Jakubowski H, Jain MR, Chen W, Li H, Tyagi S, Mandecki W. Design and properties of efficient tRNA:EF-Tu FRET system for studies of ribosomal translation. Protein Eng Des Sel. 2013;26:347-57.

30. Kim JB, Deluna A, Mungrue IN, Vu C, Pouldar D, Civelek M, Orozco L, Wu J, Wang X, Charugundla S, Castellani LW, Rusek M, Jakubowski H, Lusis AJ. Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation. 2012;126:1896-906. Erratum in: Circulation. 2013;127:549.

31. Stroylova YY, Chobert JM, Muronetz VI, Jakubowski H, Haertlé T. N-homocysteinylation of ovine prion protein induces amyloid-like transformation. Arch Biochem Biophys. 2012;526:29-37.

32. Borowczyk K, Tisończyk J, Jakubowski H. Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase. Amino Acids. 2012;43:1339-48.

33. Borowczyk K, Shih DM, Jakubowski H. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1. J Alzheimers Dis. 2012;30:225-31.

34. Bogdanski P, Miller-Kasprzak E, Pupek-Musialik D, Jablecka A, Lacinski M, Jagodzinski PP, Jakubowski H. Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension. Clin Chem Lab Med. 2012;50:1107-13.

35. Perła-Kaján J, Gryszczyńska A, Mielcarek S, Jakubowski H. Cation exchange HPLC analysis of desmosines in elastin hydrolysates. Anal Bioanal Chem. 2011;401:2473-9.

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36. Stroylova YY, Zimny J, Yousefi R, Chobert JM, Jakubowski H, Muronetz VI, Haertlé T. Aggregation and structural changes of α(S1)-, β- and κ-caseins induced by homocysteinylation. Biochim Biophys Acta. 2011 Jun 12;1814(10):1234-1245.

37. Marczak L, Sikora M, Stobiecki M, Jakubowski H. Analysis of site-specific N-homocysteinylation of human serum albumin in vitro and in vivo using MALDI-ToF and LC-MS/MS mass spectrometry. Journal of Proteomics 2011; 74:967-74.

38. Glowacki R, Bald E, Jakubowski H. An on-column derivatization method for the determination of homocysteine-thiolactone and protein N-linked homocysteine. Amino Acids. 2011;41:187-94.

39. Ząbczyk M, Głowacki R, Machnik A, Heród P, Kazek G, Jakubowski H, Undas A. Elevated concentrations of Nɛ-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation. Clin Chem Lab Med. 2011;49:729-35.

40. Sikora, M. Marczak L, Twardowski T, Stobiecki M, Jakubowski H. Direct monitoring of albumin lysine-525 N-homocysteinylation in human serum by LC/MS. Analytical Biochemistry. 2010;405:132-4.

41. Glowacki R, Bald E, Jakubowski H. Identification and origin of Nɛ-homocysteinyl-lysine isopeptide in humans and mice. Amino Acids. 2010;39:1563-9.

42. Glowacki R, Borowczyk K, Bald E, Jakubowski H. On-column derivatization with o-phthaldialdehyde for fast determination of homocysteine in human urine. Analytical Bioanalytical Chemistry. 2010;396:2363-6.

43. Perla-Kajan J, Lin X, Cooperman BS, Goldman E, Jakubowski H, Knudsen CR, Mandecki W. Properties of Escherichia coli EF-Tu mutants designed for fluorescence resonance energy transfer from tRNA molecules. Protein Engineering Design & Selection. 2010;23:129-36.

44. Suszynska J, Tisonczyk J, Lee HG, Smith MA, Jakubowski H. Reduced Homocysteine-Thiolactonase Activity in Alzheimer's Disease. Journal of Alzheimers Disease. 2010;19:1177-83.

45. Beltowski J, Wójcicka G, Jakubowski H. Modulation of paraoxonase 1 and protein N-homocysteinylation by leptin and the synthetic liver X receptor agonist T0901317 in the rat. Journal of Endocrinol. 2010;204:191-8.

46. Perla-Kajan J, Jakubowski H. Paraoxonase 1 protects against protein N-homocysteinylation in humans. FASEB Journal. 2010;24:931-6.

47. Sikora M, Jakubowski H. Homocysteine editing and growth inhibition in Escherichia coli. Microbiology 2009;155:1858-65.

48. Jakubowski H, Perla-Kajan J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB Journal 2009;23:1721-7.

49. Van Campenhout A, Moran CS, Parr A, Clancy P, Rush C, Jakubowski H, Golledge J. Role of homocysteine in aortic calcification and osteogenic cell differentiation. Atherosclerosis 2009;202:557-66.

50. Jakubowski H, Boers GH, Strauss KA. Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans. FASEB Journal 2008;22:4071-4076.

51. Jakubowski H. A new method for the determination of protein N-linked homocysteine. Analytical Biochemistry. 2008;380:257-261.

52. Perła-Kaján J, Stanger O, Luczak M, Ziółkowska A, Malendowicz LK, Twardowski T, Lhotak S, Austin RC, Jakubowski H. Immunohistochemical detection of N-homocysteinylated proteins in humans and mice. Biomedicine and Pharmacotherapy. 2008;62:473-479.

53. Bogdanski P, Pupek-Musialik D, Dytfeld J, Lacinski M, Jablecka A, Jakubowski H. (2008) Plasma homocysteine is a determinant of tissue necrosis factor-alpha in hypertensive patients. Biomedicine and Pharmacotherapy 2008;62;360-365.

54. Jakubowski H. (2007) Facile syntheses of [35S]homocysteine-thiolactone, [35S]homocystine, [35S]homocysteine, and [S-nitroso-35S]homocysteine. Analytical Biochemistry 370, 124-126.

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55. Chwatko G, Boers GH, Strauss KA, Shih DM, Jakubowski H. (2007) Mutations in methylenetetrahydrofolate reductase or cystathionine β-syntase gene and high methionine diet increase homocysteine-thiolactone levels in humans and mice. FASEB Journal 21, 1707-1713.

56. Jiang XH, Yang F, Brailoiu E, Jakubowski H, Dun NJ, Schafer AI, Yang XF1, 4, 5, Durante W, Wang H. (2007) Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology 27, 1976-83.

57. Perla-Kaján J, Marczak L, Kaján L, Skowronek P, Twardowski T, Jakubowski H. (2007) Modification by homocysteine thiolactone affects redox status of cytochrome c. Biochemistry 46, 6225-6231.

58. Holmes DH, Puffenberger EG, Hendrickson C, Robinson DL, Wagner C, Stabler SP, Allen RH, Chwatko G, Jakubowski H, Niculescu MD, Mudd SH. (2007) Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency. Molecular Genetics and Metabolism 91, 165-175.

59. Jakubowski H. (2006) The mechanism of the condensation of homocysteine-thiolactone with aldehydes. Chemistry – A European Journal 12, 8039-8043.

60. Undas A, Stepien E, Glowacki R, Tisonczyk J, Tracz W, Jakubowski H. (2006) Folic acid administration and autoantibodies against N-homocysteinylated proteins in subjects with hyperhomocysteinemia. Thrombosis and Haemostasis 96, 342-347.

61. Zimny J, Sikora M, Guranowski A, Jakubowski H. (2006) Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase. Journal of Biological Chemistry 281: 281,22485-22492.

62. Domagala TB, Lacinski M, Trzeciak WH, Mackness B, Mackness MI, Jakubowski H. (2006) The correlation of homocysteine-thiolactonase activity of the paraoxonase (PON1) protein with coronary heart disease status. Cellular and Molecular Biology 52, 4-10.

63. Undas A, Brozek J, Jankowski M, Szczeklik A, Jakubowski H. (2006) Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects. Arteriosclerosis, Thrombosis and Vascular Biology 26, 1397-1404.

64. Taurog RE, Jakubowski H, Matthews RG. (2006) Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase. Biochemistry 45,5083-91.

65. Chwatko G, Jakubowski H. (2005) Urinary excretion of homocysteine-thiolactone in humans. Clinical Chemistry 51, 408-415.

66. Chwatko G, Jakubowski H. (2005) The determination of homocysteine-thiolactone in human plasma. Analytical Biochemistry 337, 271-277.

67. Undas A, Jankowski M, Padjas A, Jakubowski H, Szczeklik A. (2005) Antibodies to N-homocysteinylated albumin as a marker for early-onset coronary artery disease in men. Thrombosis and Haemostasis 93, 346-350.

68. Lacinski M, Skorupski W, Cieslinski A, Sokolowska J, Trzeciak WH, Jakubowski H. (2004) Determinants of homocysteine-thiolactonase activity of the PON1 protein in humans. Cellular and Molecular Biology 50, 858-893.

69. Perla J, Undas A, Twardowski T, Jakubowski H. (2004) Purification of antibodies against N-homocysteinylated proteins by affinity chromatography on Nω-homocysteinyl-aminohexyl-Agarose. Journal of Chromatography B 807, 257-261.

70. Undas A, Perla J, Lacinski M, Trzeciak W, Kazmierski R, Jakubowski, H. (2004) Autoantibodies against N-homocysteinylated-proteins in humans: Implications for atherosclerosis. Stroke, 35, 1299-1304.

71. Di Giuseppe D, Frosali S, Priora R, Cellesi C, Bonocore G, Passini FL, Lazzerini PE, Di Sipmlicio FC, Jakubowski H., Di Simplicio P. (2004) The redox status of plasma thiols in normal individuals by age and in patients with mild hyperhomocysteinemia. Journal of Laboratory and Clinical Medicine 144, 235-245.

72. Glowacki R, Jakubowski H. (2004) Cross-talk between Cys-34 and lysine residues in human serum albumin revealed by N-homocysteinylation. Journal of Biological Chemistry 279, 10864-10871.

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73. Jakubowski H, Guranowski A. (2003) Metabolism of homocysteine thiolactone in plants. Journal of Biological Chemistry 278, 6765-6770.

74. Schork NJ, Gardner JP, Zhang L, Fallin D, Thiel B, Jakubowski H, Aviv A. (2002) Genomic association/linkage of sodium lithium counter-transport in CEPH pedigrees. Hypertension 40, 619-28.

75. Jakubowski H. (2002) Homocysteine is a protein amino acid in humans: Implications for homocysteine-linked disease. Journal of Biological Chemistry 177, 21813-21816.

76. Jakubowski H. (2002) The determination of homocysteine thiolactone in biological samples. Analytical Biochemistry 308, 112-119.

77. Despons L, Senger B, Jakubowski H, Fasiolo F. (2001) Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetase: Two structural frameworks for identical functions. Journal of Molecular Biology 311, 205-16.

78. Jakubowski H, Ambrosius W, Pratt JH. (2001) Genetic determinants of homocysteine thiolactonase activity in humans: Implications for atherosclerosis. FEBS Lett. 491, 35-9.

79. Jakubowski H. (2000) Amino acid selectivity in the aminoacylation of coenzyme A and RNA minihelices by aminoacyl-tRNA synthetases. Journal of Biological Chemistry 275, 3485-8.

80. Jakubowski H, Zhang L, Bardeguez A, Aviv A. (2000) Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: Implications for atherosclerosis. Circulation Research 87, 45-51.

81. Jakubowski H. (2000) Translational incorporation of S-nitrosohomocysteine into protein. Journal of Biological Chemistry 275, 21813-6.

82. Jakubowski H. (2000) Calcium-dependent homocysteine thiolactone hydrolase: A protective mechanism against protein N-homocysteinylation. Journal of Biological Chemistry 275, 3957-62.

83. Jakubowski H. (1999) Protein Homocysteinylation: Possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB Journal 13, 2277-83.

84. Jakubowski H. (1999) Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase. Biochemistry 38, 8088-93.

85. Kim HY, Pak M, Jakubowski H. (1999) A site in the dinucleotide-fold domain contributes to the accuracy of tRNA selection by Escherichia coli Met-tRNA synthetase. Molecular Cells 8, 623-8.

86. Jakubowski H. (1998) Aminoacylation of coenzyme A and pantetheine by aminoacyl-tRNA synthetases: Possible link between non-coded and coded peptide synthesis. Biochemistry 37, 5147-53.

87. Jakubowski H. (1997) Aminoacyl thioester chemistry of class II aminoacyl-tRNA synthetases. Biochemistry 36, 11077-85.

88. Jakubowski H. (1997) Metabolism of homocysteine thiolactone in human cells: Possible mechanism for pathological consequences of elevated homocysteine levels. Journal of Biological Chemistry 272, 1935-42.

89. Jakubowski H. (1996) Proofreading in trans by an aminoacyl-tRNA synthetase: A model for single site editing by isoleucyl-tRNA synthetase. Nucleic Acids Res. 24, 2505-10.

90. Jakubowski H. (1996) The synthetic/editing active site of an aminoacyl-tRNA synthetase: Evidence for binding of thiols in the editing subsite. Biochemistry 35, 8252-9.

91. Jakubowski H. (1995) Synthesis of cysteine-containing dipeptides by aminoacyl-tRNA synthetases. Nucleic Acids Research 23, 4608-15.

92. Gao W, Jakubowski H, Goldman E. (1995) Evidence that uncharged tRNA can inhibit a programmed translational frameshift in Escherichia coli. Journal of Molecular Biology 251, 210-6.

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93. Jakubowski H. (1995) Proofreading in vivo: Editing of homocysteine by aminoacyl-tRNA synthetases in Escherichia coli. Journal of Biological Chemistry 270, 17672-3.

94. Gao W, Goldman E, Jakubowski H. (1994) Role of carboxy terminal region in proofreading function of methionyl-tRNA synthetase in Escherichia coli. Biochemistry 33, 11528-35.

95. Jakubowski H. (1994) Editing function of Escherichia coli cysteinyl-tRNA synthetase: Cyclization of cysteine to cysteine thiolactone. Nucleic Acids Research . 22, 1155-60.

96. Kim HY, Ghosh G, Schulman LH, Brunie S, Jakubowski H. (1993) The relationship between synthetic and editing functions of the active sites of an aminoacyl-tRNA synthetase. Proceedings of the National Academy of Sciences of the USA 90, 11553-7.

97. Jakubowski H, Goldman, E. (1993) Methionine-mediated lethality in yeast cells atelevated temperature. Journal of Bacteriology175, 5467-76.

98. Jakubowski H. & Goldman, E. (1993) Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells. FEBS Lett. 317, 237-40.

99. Jakubowski H. (1993) Proofreading and the evolution of a methyl donor function: Cyclization of methionine to S-methyl-homocysteine thiolactone by Escherichia coli methionyl-tRNA synthetase. Journal of Biological Chemistry 268, 6549-53.

100.Jakubowski H. (1993) The energy cost of proofreading in vivo: The charging of methionine tRNAs. FASEB Journal 7, 168-72.

101.Cai XY, Jakubowski H., Redfield B, Zaleski B, Brot N, Weissbach H. (1992) Role of metF and metJ genes in the vitamin B12 regulation of methionine gene expression: Involvement of N5-methylenetetrahydrofolic acid. Biochem. Biophys. Res. Commun. 182, 651-8.

102.Jakubowski H. (1991) Proofreading in vivo: Editing of homocysteine by methionyl-tRNA synthetase in the yeast Saccharomyces cerevisiae. EMBO Journal 10, 593-8.

103.Rojiani MV, Jakubowski H, Goldman E. (1990) Relationship between protein synthesis and concentrations of charged and uncharged tRNATrp in Escherichia coli. Proceedings of the National Academy of Sciences of the USA 87, 1511-5.

104.Jakubowski H. (1990) Proofreading in vivo: Editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli. Proceedings of the National Academy of Sciences of the USA 87, 4504-8.

105.Rojiani MV, Jakubowski H, Goldman E. (1989) Effect of variation of charged and uncharged tRNATrp levels on ppGpp synthesis in Escherichia coli. Journal of Bacteriology 171, 6493-502.

106.Jakubowski H, Goldman E. (1988) Evidence for cooperation between cells during sporulation of the yeast Saccharomyces cerevisiae. Molecular and Cellular Biology 8, 5166-78.

107.Guranowski A, Just G, Holler E, Jakubowski H. (1988) Synthesis of AppppA from adenosine 5'-phosphosulfate and ATP by yeast AppppA phosphorylase. Biochemistry 27, 2959-64.

108.Jakubowski H. (1988) Negative correlation between the abundances of Escherichia coli aminoacyl-tRNA families and their affinities for elongation factor Tu-GTP. Journal of Theoretical Biology 133, 363-70.

109.Szczotka Z, Lewandowska U, Jakubowski H. (1988) Endogenous and exogenous polyamines in dormancy breaking of Acer platanoides seeds under conditions of cold stratification. Acta Physiol. Plant. 10, 181-9.

110.Guranowski A, Biryukov A, Tarussova NB, Khomutov RM, Jakubowski H. (1987) Phosphonate analogues of diadenosine 5',5'''-P1,P4-tetraphosphate as substrates or inhibitors of procaryotic and eucaryotic enzymes degrading dinucleoside tetraphosphates. Biochemistry 26, 3425-9.

111.Jakubowski H. (1986) Sporulation of the yeast Saccharomyces cerevisiae is accompanied by synthesis of adenosine 5'-tetraphosphate and adenosine

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5'-pentaphosphate. Proceedings of the National Academy of Sciences of the USA 83, 2378-82.

112.Jakubowski H, Goldman, E. (1984) Quantities of individual aminoacyl-tRNA families and their turnover in Escherichia coli. Journal of Bacteriology158, 769-76.

113.Koontz SW, Jakubowski H, Goldman E. (1983) Control of RNA and protein synthesis by the concentration of Trp-tRNATrp in Escherichia coli infected with bacteriophage MS2. Journal of Molecular Biology 168, 747-63.

114.Guranowski A, Jakubowski H, Holler E. (1983) Catabolism of diadenosine 5',5'''-P1,P4- tetraphosphate (Ap4A) in procaryotes. Purification and properties of Ap4A (symmetrical) pyrophosphohydrolase from E. coli K-12. Journal of Biological Chemistry 258, 14784-9.

115.Jakubowski H, Guranowski A. (1983) Enzymes hydrolyzing AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase and phosphodiesterase from yellow lupine (Lupinus luteus) seeds. J Biol Chem 258, 9982-9.

116.Jakubowski H. (1983) Synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate and related compounds by plant (Lupinus luteus) seryl-tRNA and phenylalanyl-tRNA synthetases. Acta Biochimica Polonica 30, 51-69.

117.Guranowski A, Jakubowski H. (1983) Substrate specificity of S-adenosylhomocysteinase. Cysteine is a substrate of the plant and mammalian enzymes. Biochim Biophys Acta 742, 250-6.

118.Jakubowski H. (1982) The mechanism of inhibition of valyl-tRNA synthetase by S-adenosylhomocysteine. Biochimica et Biophysica Acta 709, 325-31.

119.Janowicz ZA, Augustyniak H, Kedzierski W, Jakubowski H, Augustyniak J. (1981) Gel mapping of wheat and lupine tRNAs. Acta Biochimica Polonica 28, 105-10.

120.Jakubowski H, Guranowski A. (1981) S-adenosylhomocysteinase from yellow lupine seeds: Stoichiometry and reactions of the enzyme-adenosine complex. Biochemistry 20, 6877-81.

121.Jakubowski H, Fersht AR. (1981) Alternative pathways of rejection of noncognate amino acids by aminoacyl-tRNA synthetases. Nucleic Acids Research 9, 3105-17.

122.Jakubowski H. (1980) Valyl-tRNA synthetase from yellow lupine seeds: Hydrolysis of the enzyme bound noncognate aminoacyl adenylate as a possible mechanism of increasing specificity of the aminoacyl-tRNA synthetase. Biochemistry 19, 507 1-8.

123.Loftfield RB., Eigner EA, Pastuszyn A, Lovgren TNE, Jakubowski H. (1980) Conformational changes during enzyme catalysis: Role of water in the transition state. Proceedings of the National Academy of Sciences of the USA 77, 3374-8.

124.Jakubowski H. (1980) The plant aminoacyl-tRNA synthetases: 2'-deoxyATP vs. ATP in rea-ctions catalyzed by yellow lupine aminoacyl-tRNA synthetases.Acta Biochim Polon 27, 321-33.

125.Jakubowski H. (1980) Polyamines and yellow lupine aminoacyl-tRNA synthetases: Spermine and spermidine help to maintain the active structures of aminoacyl-tRNA synthetases. FEBS Leters. 109, 63-6.

126.Jakubowski H. (1979) A role for protein-protein interactions in the maintenance of active forms of aminoacyl-tRNA synthetases. FEBS Letters 103, 71-6.

127.Jakubowski H. & Guranowski, A. (1978) Adenosylhomocysteinase:adenosine complex. Biochemical and Biophysical Research Communications 84, 1060-8.

128.Jakubowski H. (1978) Valyl-tRNA synthetase from yellow lupine seeds: Instability of enzyme-bound noncognate adenylate vs. cognate adenylate. FEBS Letters 95, 235-38.

129.Jakubowski H. (1978) Yellow lupine (Lupinus luteus) aminoacyl-tRNA synthetases: Isolation and some properties of enzyme-bound valyl-adenylate and seryl-adenylate. Biochimica et Biophysica Acta 521, 584-96.

130.Jakubowski H, Pastuszyn A, Loftfield RB. (1978) The mechanism of aminoacylation of transfer RNA: the kinetics and stoichiometry of the lysis of aminoacyl-tRNA. Biochimica et Biophysica Acta 520, 568-76.

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131.Jakubowski H. (1978) Incomplete aminoacylation of tRNALeu catalyzed by Escherichia coli B leucyl-tRNA synthetase. Biochimica et Biophysica Acta 518, 345- 50.

132.Jakubowski H, Pastuszyn A, Loftfield RB. (1977) The determination of aminoacyl adenylate by thin layer chromatography. Analytical Biochemistry 82, 29-37.

133.Jakubowski H, Pawelkiewicz J. (1977) The plant aminoacyl-tRNA synthetases: Effect of sodium chloride on tRNA aminoacylation and aminoacyl-tRNA decomposition catalyzed by aminoacyl-tRNA synthetases from yellow lupine seeds. Acta Biochimica Polonica 24, 163-70.

134.Jakubowski H. (1977) ω-Aminohexyl-Sepharose: Use in the fractionation of Escherichia coli B aminoacyl-tRNA synthetases. Journal of Chromatography 139, 331-6.

135.Jakubowski H, Pawelkiewicz J. (1975) Fractionation of plant aminoacyl-tRNA synthetases on tRNA-Sepharose columns. Biochimica et Biophysica Acta 407, 213-21.

136.Jakubowski H, Pawelkiewicz J. (1975) The plant aminoacyl-tRNA synthetases: Purification and characterization of valyl-tRNA, tryptophanyl-tRNA and seryl-tRNA synthetases from yellow lupine seeds. European Journal of Biochemistry 52, 301-10.

137.Dziegielewski T, Jakubowski H. (1975) ω-Aminohexyl-Sepharose 4B, a new support for tRNA fractionation. Journal of Chromatography 103, 364-7.

138.Wierzbicka H, Jakubowski H, Pawelkiewicz J. (1975) Transfer RNA methyl-transferases from yellow lupine seeds: Purification and properties. Nucleic Acids Research 2, 101-11.

139.Jakubowski H, Pawelkiewicz J. (1974) Valyl-tRNA synthetase of yellow lupine seeds: Purification and properties. Acta Biochimica Polonica 21, 271-82.

140.Jakubowski H, Pawelkiewicz J. (1973) Chromatography of plant aminoacyl-tRNA Synthetases on ω-aminohexyl-Sepharose columns. FEBS Leters 34, 150-4.

B. Books, Monographs and ChaptersAuthors names (Last, First; Bold CV author); Chapter # and Title; In: Book Title (Textbook), # Edition; Editor; page numbers; Publisher, city, state; year

1. Jakubowski H (2015) Transfer RNA Synthetase Editing of Errors in Amino Acid Selection. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0026084]

2. Jakubowski, H. Homocysteine in Protein Structure/Function and Human Disease – Chemical Biology of Homocysteine-containing Proteins, Springer, Wien, New York, 2013, XIII, 166 p. 49 illus., 9 illus. in color. Hardcover: ISBN 978-3-7091-1409-4

3. Jakubowski H. (2010) The Role of Paraoxonase 1 in the Detoxification of Homocysteine Thiolactone. In Reddy ST, ed. Paraoxonases in Inflammation, Infection, and Toxicology, Humana Press, New York, NY, pp.113-128.

4. Jakubowski H. (2009) The Origin and Role of N-Homocysteinylated Proteins in Cardiovascular Disease. In Brataas J, Nanstveit V, eds. Handbook of Cardiovascular Research, Nova Science Publishers Inc, Hauppaugue, New York, pp. 113-144.

5. Jakubowski H. (2009) Homocysteine metabolism and pathological implications. In Masella R, Mazza G, eds. Glutathione and Sulfur Amino Acids in Human Health and Disease, John Wiley and Sons, Hoboken, New Jersey, pp. 363-411.

6. Jakubowski H. (2008) The origin and role of autoantibodies against N-homocysteinylated protein in human cardiovascular disease. In Dubois QP , ed. Autoantibodies Research Progress, Nova Science Publishers Inc, Hauppaugue, New York, pp. 69-98.

7. Jakubowski H. (2007) Paraoxonase 1 (PON1), A Junction between Metabolisms of Homocysteine and Lipids. In Mackness M, Mackness B, Aviram M, Paragh G, eds. The Paraoxonases: Their role in Disease Developments and Xenobiotic Metabolsim, Springer, Heidelberg, Germany, pp. 87-102.

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8. Jakubowski H (2005) Transfer RNA Synthetase Editing of Amino Acids. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003933]

9. Jakubowski H. (2005) Accuracy of Aminoacyl-tRNA Synthetases: Proofreading of Amino Acids. In Ibba M, Francklyn C, Cusack S, eds. The Aminoacyl-tRNA Synthetases, Landes Bioscience, Georgetown, TX, pp. 384-396.

10. Jakubowski H. (2001) tRNA synthetase proofreading of amino acids. In Encyclopedia of Life Sciences. Nature Publishing Group, London, UK (http://www.els.net).

11. Jakubowski H. (2001) Biosynthesis and reactions of homocysteine thiolactone. In Jacobson D, Carmel R, eds. Homocysteine in Health and Disease. Cambridge University Press, UK, pp 21-31.

12. Jakubowski H. (1997) Synthesis of homocysteine thiolactone in normal and malignant cells. In: Rosenberg IH, Graham I, Ueland PM, Refsum H, eds. Homocysteine Metabolism: From Basic Science to Clinical Medicine. Kluwer Academic Publishers, Norwell, MA, pp.157-165.

13. Jakubowski H. (1994) Energy cost of translational proofreading in vivo: The aminoacylation of transfer RNA in Escherichia coli. Ann NY Acad Sci 745, 4-20.

14. Guranowski A., Jakubowski H. (1987) Adenosylhomocysteinase (Yellow lupin). Methods in Enzymology 143, 430-434.

15. Jakubowski H. (1982) The polyamine specificity of the tRNAVal aminoacylation reaction catalyzed by prokaryotic (Escherichia coli) and eukaryotic (plant, Lupinus luteus) valyl-tRNA synthetases. Advances in Polyamine Research 4, 307-317.

C. Patents HeldTitle, U.S. Patent Number, Date of Issue, Inventors

1. Method for analyzing albumin-N-homocysteinylation in bio-sample, involves determining relationship between amount of modified peptide and total homocysteine in serum samples from coronary heart disease patients. Inventor(s): Jakubowski H, Marczak L, Sikora M, Stobiecki M, Twardowski T. Patent Number: PL391441-A1 (19 Dec 2011); PL214635-B1 (30 Aug 2013).

2. Method for determining expression of miRNA molecules, involves determining expression of miRNA molecules as tool to diagnosis early stages of cardiovascular disease (Sposób określania zmian ekspresji cząsteczek miRNA in vitro w celu oznaczania wczesnych chorobowych zmian strukturalnych śródbłonka naczyń krwionośnych spowodowanych hiperhomocysteinemią). Inventor(s): Gurda D, Jakubowski H, Kietrys A M, Handschuh L, Figlerowicz M, Twardowski T, Suszynska-Zajczyk J. Patent Number(s): P.402291 (07 Jul 2014; final 03 Aug 2017)

3. Bio-marker molecular model diagnostic tool for determining risks of cardiovascular disease as a tool for determining miRNA molecules during cardiovascular disease diagnosis process (Zastosowanie molekularnych biomarkerów do oznaczania wczesnych chorobowych zmian strukturalnych śródbłonka naczyń krwionośnych spowodowanych hiperhomocysteinemią wywołaną podwyższonym poziomem tiolaktonu homocysteiny we krwi). Inventor(s): Gurda D, Jakubowski H, Kietrys A M, Handschuh L, Figlerowicz M, Twardowski T, Suszynska-Zajczyk J. Patent Number(s): P.402289 (07 Jul 2014; final 03 Aug 2017)

D. Other Articles (Reviews, Editorials, etc.) In Journals; Chapters; Books; other Professional Communications

Authors names (Last, First; Bold CV author); Title of Article; Journal Name, Volume#: first-last page, year

1. Jakubowski H. Protein N-Homocysteinylation and Colorectal Cancer. Trends in Cancer 2018, Oct 20.

2. Jakubowski H. Homocysteine modification in protein structure/function and human disease. Physiol Rev 2018; accepted June 27.

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http://www.els.net/

3. Jakubowski H. Homocysteine in Protein Structure/Function and Human Disease - Chemical Biology of Homocysteine-containing Proteins. Wien: Springer, 2013.

4. Jakubowski, H. The Mechanism and Consequences of Homocysteine Incorporation into Protein in Humans. Phosphorus Sulfur and Silicon and the Related Elements. 2013;188:384-395.

5. Perła-Kaján J, Jakubowski H. Paraoxonase 1 and homocysteine metabolism. Amino Acids. 2012;43:1405-17.

6. Jakubowski H. Quality Control in tRNA Charging. Wiley Interdiscip Rev RNA. 2012;3:295-310.

7. Jakubowski H., Glowacki, R. Chemical Biology of Homocysteine Thiolactone and Related Metabolites. Advances in Clinical Chemistry 2011;55:81-103.

8. Jakubowski H. Quality Control in tRNA Charging - Editing of Homocysteine. Acta Biochim Pol 2011:58:149-63.

9. Jakubowski H. The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease. J Physiol Pharmacol. 2008;59 Suppl 9:155-167.

10. Jakubowski H. The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease. Clinical Chemistry and Laboratory Medicine 2007;45: 1704-16.

11. Perla-Kajan J, Twardowski T, Jakubowski H. Mechanisms of homocysteine toxicity in humans. Amino Acids 2007; 32:561-72.

12. Jakubowski H. Pathophysiological consequences of homocysteine excess. Journal of Nutrition 2006;136:1741S-1749S.

13. Sikora M, Twardowski T, Jakubowski H. The role of homocysteine thiolactone in some of human diseases Postepy Biochem. 2006;52(4):417-23.

14. Jakubowski H. Anti-N-homocysteinylated protein autoantibodies and cardiovascular disease. Clinical Chemistry and Laboratory Medicine 2005;43:1011-1014.

15. Jakubowski H. (2004) Molecular basis of homocysteine toxicity in humans. Cellular and Molecular Life Sciences 61, 470-487.

16. Jakubowski H. (2003) Homocysteine-thiolactone and S-nitroso-homocysteine mediate incorporation of homocysteine into protein in humans. Clinical Chemistry and Laboratory Medicine 41, 1462-1466.

17. Jakubowski H. (2002) From Accuracy in Protein Synthesis to Cardiovascular Disease: The Role of Homocysteine. Biotechnologia(Poznan) 58, 11-24.

18. Jakubowski H. (2001) Protein N-homocysteinylation: Implications for atherosclerosis. Biomedicine and Pharmacotherapy 55, 443-7.

19. Jakubowski H. (2001) Translational accuracy of aminoacyl-tRNA synthetases: Implications for atherosclerosis Journal of Nutrition, 131, 2983S-2987S.

20. Jakubowski H. (2000) Homocysteine thiolactone: Metabolic origin and protein homocysteinylation in humans. Journal of Nutrition 130, 377S-381S.

21. Jakubowski H, Goldman E. (1992) Editing of errors in selection of amino acids for protein synthesis. Microbiological Reviews 56, 412-429.

22. Goldman E, Jakubowski H. (1990) Uncharged tRNA, protein synthesis, and the bacterial stringent response. Molecular Microbiology 4, 2035-2040.

23. Jakubowski H. (1974) Aminoacyl-tRNA Synthetases (Article in Polish). Postepy Biochemii 21, 95-112.

E. Abstracts (presenting author in bold)1. Utyro O, Perła-Kajan, Kubalska J, Kozich V, Jakubowski H. Telomere length is not related

to homocysteine and life span in cystathionine-β synthase-deficient mice and humans. 3rd Congress of Polish Biosciences BIO2018, Gdańsk, September 18-21, 2018.

2. Perła-Kaján J, Zimny J, Malinowska A, Cysewski D, Jakubowski H. Proteomic analysis reveals deregulated protein folding, oxidative stress, and apoptosis signaling pathways in the yeast Saccharomyces cerevisiae model of hyperhomocysteinemia. 3rd Congress of Polish Biosciences BIO2018, Gdańsk, September 18-21, 2018.

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3. Wróblewski J, Bretes E, Jakubowski H. Changes in MUPs expression patterns induced by Cbs deficiency in mice are mediated by liver Zhx2 and androgen receptor. 3rd Congress of Polish Biosciences BIO2018, Gdańsk, September 18-21, 2018.

4. Bielińska I, Sikora M, Jakubowski H. Methionine-induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation. 3rd Congress of Polish Biosciences BIO2018, Gdańsk, September 18-21, 2018.

5. Witucki Ł, Suszyńska-Zajczyk J, Wróblewski J, Filipkowski RK, Jakubowski H. Hyperhomocysteinemia causes cognitive impairment by hyper-activating mTOR and impairing autophagy via the inhibition of Phf8 histone demethylase in mice. FASEB Conference on “Folic Acid, Vitamin B12, and One‐Carbon Metabolism”, Western Shore, Nova Scotia, Canada, Jul 29 -Aug 3, 2018. (Selected for platform presentation).

6. Perła-Kaján J, Borowczyk K, Bakker SJL, Jakubowski H. Paraoxonase 1 activity affects homocysteine thiolactone levels in renal transplant receipients. FASEB SRC on “Folic Acid, Vitamin B12, & One-Carbon Metabolism”, Western Shore, Nova Scotia, Canada, Jul 29 - Aug 3, 2018. (Selected for platform presentation).

7. Sikora M, Marczak Ł, Perła-Kajan J, Jakubowski H. Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice. FASEB SRC on “Folic Acid, Vitamin B12, & One-Carbon Metabolism”, Western Shore, Nova Scotia, Canada, Jul 29 - Aug 3, 2018.

8. Suszyńska-Zajczyk J, Wróblewski J, Filipkowski RK, Jakubowski H. Dietary hyperhomocysteinemia accelerates neurodegeneration by upregulating mTRO signaling and impairing autophagy in the mouse brain. Advances in Alzheimer’s and Parkinson’s therapies – An AAT-AD/PD Focus Meeting. Torino, Italy, March 15-18, 2018.

9. Jakubowski H, Borowczyk K, Głowacki R, Perła-Kaján J, Ueland PM, Nygård O. Homocysteine-thiolactone predicts myocardial infarction in a randomized controlled trial. Keystone Symposia – Atherosclerosis. Taos, NM, Feb 4-8, 2018.

10. Suszyńska-Zajczyk J, Śliwowska JH, Jakubowski H. Dietary hyperhomocysteinemia reduces brain AQP4 expression and cognitive performance in old mice. 13th International Congress of the Polish Neuroscience Society. Warsaw, Poland, August 28-30, 2017.

11. Wróblewski J, Bretes E, Perła-Kaján J, Jakubowski H. Transcriptional Repression of Male‐specific MUP20 Expression in Female Mice is relieved by the Inactivation of Cystathionine‐β Synthase Gene. 11th Intl Conference on Homocysteine and One Carbon Metabolism, Aarhus, Denmark, May 14-18, 2017 (Selected for platform presentation).

12. Perła-Kaján J, Borowczyk K, Glowacki R, Nygård O, Ueland PM, Jakubowski H. Paraoxonase 1 protects against homocysteine-thiolactone accumulation in humans. 11th Intl Conference on Homocysteine and One Carbon Metabolism, Aarhus, Denmark, May 14-18, 2017 (Selected for platform presentation).

13. Borowczyk K, Jakubowski H. Methionine demethylation and protein damage: time-dependent accumulation of homocysteine in human hair keratin. 11th Intl Conference on Homocysteine and One Carbon Metabolism, Aarhus, Denmark, May 14-18, 2017.

14. Utyro O, Jakubowski H. Telomere Length Is Not Affected by the Cystathionine‐β Synthase (Cbs) Genotype, Age, and Life Span In Mice. 11th Intl Conference on Homocysteine and One Carbon Metabolism, Aarhus, Denmark, May 14-18, 2017.

15. Bielińska I, Marczak Ł, Jakubowski H. Cystathionine ß-synthase deficiency induces changes in the mouse brain proteome associated with neurodegenerative disease. 11th Intl Conference on Homocysteine and One Carbon Metabolism, Aarhus, Denmark, May 14-18, 2017

16. Sikora M, Bielinska I, Marczak Ł, Jakubowski H. Label-free proteomic analysis of plasma of cystathionine β-synthase deficient mice and humans reveals changes in blood coagulation, hemostasis and antioxidant activity. 11th Intl Conference on Homocysteine and One Carbon Metabolism, Aarhus, Denmark, May 14-18, 2017

17. Perła-Kaján J, Rusek M, Malinowska A, Sitkiewicz E, Utyro O, Jakubowski H. N‐homocysteinylation impairs collagen cross-linking in cystathionine β‐synthase-deficient mice: a novel mechanism of connective tissue abnormalities. 11th Intl Conference on Homocysteine and One Carbon Metabolism, Aarhus, Denmark, May 14-18, 2017.

18. Perła-Kaján J, Rusek M, Malinowska A, Sitkiewicz E, Utyro O, Jakubowski H. N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase deficient

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mice: A novel mechanism of connective tissue abnormalities. FASEB SRC on “Folic Acid, Vitamin B12, & One-Carbon Metabolism”, Steamboat Springs, CO, USA, August 7-12, 2016.

19. Jakubowski H, Borowczyk K, Glowacki R, Nygård O. Urinary Homocysteine Thiolactone Predicts Acute Myocardial Infarction in a Randomized Controlled Homocysteine-lowering B-vitamin Trial. American Heart Association Conference, Orlando, FL, November 7-11, 2015 Circulation. 2015;132:A19250

20. Bielińska I, Marczak L, Jakubowski H. Analysis of liver proteome in cystathionine beta-synthase deficient mice using 2D IEF/SDS-PAGE gel electrophoresis, MALDI-TOF mass spectrometry, and label-free based relative quantitative proteomics. Conference: 29th Annual Symposium of the Protein-Society Location: Barcelona, SPAIN, JUL 22-25, 2015. Protein Science 2015;24(Suppl 1):254-255. Abstract PJ-035, Published OCT 2015.

21. Wieloch M, Jakubowski H. Paraoxonase 1 (Pon1) regulates water homeostasis by controlling the expression of Fxr and Aqp2 proteins in mice. Conference: 29th Annual Symposium of the Protein-Society Location: Barcelona, SPAIN, JUL 22-25, 2015. Protein Science 2015;24(Suppl 1):289-290. Abstract PL-046, Published OCT 2015.

22. Perła-Kajan J, Ogrodna K, Jakubowski H. Tissue-specific effect of hyperhomocysteinemia on collagen and elastin cross-links in a cystathionine β-synthase-deficient mouse. 14th Intl Congress on Amino Acids, Peptides and Proteins. Vienna, Austria, August 3-7, 2015 (invited talk). Amino Acids 2016;48:635. DOI 10.1007/s00726-015-2160-5

23. Borowczyk K, Głowacki R, Nygård O, Jakubowski H. Homocysteine-thiolactone and cardiovascular disease in B-vitamin trials. 10th Intl Conference on “One Carbon Metabolism, Vitamins B and Homocysteine”. Nancy, France, July 7-11, 2015 (selected for platform presentation).

24. Perła-Kaján J, Jakubowski H. Does hyperhomocysteinemia affect collagen and elastin cross-links in a mouse model of cystathionine β-synthase deficiency. 10th Intl Conference on “One Carbon Metabolism, Vitamins B and Homocysteine”, Nancy, France, July 7-11, 2015 (selected for platform presentation).

25. Sikora M, Marczak L, Jakubowski H. Identification of N-homocysteinylation sites in mouse plasma albumin and hemoglobin from cystathionine β-synthase deficient mice. 10th Intl Conference on “One Carbon Metabolism, Vitamins B and Homocysteine”, Nancy, France, July 7-11, 2015.

26. Borowczyk K, Jakubowski H, Głowacki R. Correlations between sulfur-containing amino acids and albumin in human plasma. 10th Intl Conference on “One Carbon Metabolism, Vitamins B and Homocysteine”, Nancy, France, July 7-11, 2015

27. Perła-Kaján J, Jakubowski H. N-Homocysteinylation, collagen and elastin crosslinks in a mouse cystathionine-β synthase deficiency model. FASEB SRC on “Folic Acid, Vitamin B12, and One-Carbon Metabolism”, Steamboat Springs, CO, USA, August 3-8, 2014 (selected for platform presentation).

28. Perła-Kaján J, Jakubowski H. N-homocysteinylation as a mechanism of connective tissue impairment in hyperhomocysteinemia due to cystathionine β-synthase deficiency. 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw, September 9-12, 2014

29. Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration. 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw, September 9-12, 2014.

30. Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H. Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration. 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw, September 9-12, 2014 (selected for platform presentation).

31. Wróblewski J, Perła-Kaján J, Wyszczelska-Rokiel M, Jakubowski H. Cystathionine-β synthase deficiency and sexual signaling in mice. FASEB SRC on “Folic Acid, Vitamin B12, and One-Carbon Metabolism”, Steamboat Springs, CO, USA, August 3-8, 2014.

32. Wróblewski J, Perła-Kaján J, Wyszczelska-Rokiel M, Jakubowski H. Cystathionine-β synthase deficiency changes expression of major urinary proteins in mice. 1st Congress of the

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Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw, September 9-12, 2014 (selected for platform presentation).

33. Utyro O, Jakubowski H. Cystathionine-β synthase deficiency affects the expression of glyoxylase domain-containing protein 4 (Glod4) gene in mice. FASEB SRC on “Folic Acid, Vitamin B12, and One-Carbon Metabolism”, Steamboat Springs, CO, USA, August 3-8, 2014.

34. Utyro O, Jakubowski H. Inactivation of the bleomycin hydrolase (Blmh) gene affects the expression of glyoxylase domain containing protein 4 (Glod4) gene in mice. 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw, September 9-12, 2014.

35. Bielińska I, Sikora M, Perła-Kajan J, Ząbczyk M, Jakubowski H. Properties of fibrin clots formed from plasma of cystathionine β-synthase-deficient patients and their unaffected family members. FASEB SRC on “Folic Acid, Vitamin B12, and One-Carbon Metabolism”, Steamboat Springs, CO, USA, August 3-8, 2014.

36. Bielińska I, Sikora M, Perła-Kajan J, Ząbczyk M, Jakubowski H. Properties of fibrin clots formed from plasma of CBS-deficient patients and their unaffected family members. 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw, September 9-12, 2014.

37. Gurda D, Marczak Ł, Jakubowski H. Histones are targeted for N-homocysteinylation in human endothelial cells. 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw, September 9-12, 2014.

38. Wróblewski J, Perla-Kajan J, Jakubowski H. Major urinary proteins are targeted for N-homocysteinylation in mice. 13th Intl Congress on Amino Acids, Peptides and Proteins. Galveston, TX, USA, Oct. 5-7 (Invited talk). Amino Acids 2013; 45(3): 605-606.

39. Wróblewski J, Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H. Inactivation of the Blmh Gene Magnifies Alterations in the Mouse Liver Proteome Induced by Hyperhomocysteinemia. 9th International Conference on Homocysteine and One-carbon Metabolism – HCY2013, Trinity College Dublin, Ireland, 8-12 September 2013. J Inherit Metab Dis 2013;36(Suppl 1):S25.

40. Perła-Kaján J, Wróblewski J*, Jakubowski H. Major Urinary Protein Levels In Cystathionine Beta β-Synthase- Deficient Mice. 9th International Conference on Homocysteine and One-Carbon Metabolism – HCY2013, Trinity College Dublin, Ireland, 8-12 September 2013. J Inherit Metab Dis 2013;36(Suppl 1):S39.

41. Wyszczelska-Rokiel M, Jakubowski H, Głowacki R. Identification of 1,3-thiazolidine derivative of pyridoxal 5’-phosphate and cysteine in human plasma. 9th International Conference on Homocysteine and One-carbon Metabolism – HCY2013, Trinity College Dublin, Ireland, 8-12 September 2013.

42. Wyszczelska-Rokiel M, Jakubowski H, Głowacki R. Determination of 1,3-thiazolidine derivative of pyridoxal 5’-phosphate and cysteine in by HPLC with UV detection. HPLC 2013- 39th Symposium on High Performance Liquid Phase Separation and Related Techniques – HPLC2013 Amsterdam, June 16-20, 2013 Inherit Metab Dis 2013;36(Suppl 1):S26.

43. Suszynska-Zajczyk J, Łuczak M, Marczak Ł, Gendaszewska-Darmach E, Twardowski T, Jakubowski H. Changes in human ednothelial cell proteom caused by N-homocysteinylated proteins. 8th Parnas Conference, Warsaw, Poland, August 27-3, 2011 (selected for platform presentation).

44. Suszynska-Zajczyk J, Tisonczyk J, Lee HG, Smith MA, Jakubowski H. Reduced Homocysteine-Thiolactonase Activity in Alzheimer's Disease. 8th Intl Conference on Homocysteine Metabolism, Lisbon, Portugal, 19-22, June, 2011, P47.

45. Sikora M, Marczak L, Twardowski T, Stobiecki M, Jakubowski H. Direct monitoring of albumin lysine-525 N-homocysteinylation in human serum as a potential marker of cardiovascular disease. 8th Intl Conference on Homocysteine Metabolism, Lisbon, Portugal, 19-22, June, 2011, P19.

46. Jakubowski H. The Role of Paraoxonase 1 in the Detoxification of Homocysteine Thiolactone. Edited by: Reddy, ST. 3rd International Conference on Paraoxonases, Univ Calif Los Angeles, Los Angeles, CA, SEP 07-10, 2008. Sponsor(s): US Def Dept, Def Threat

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Reduct Agcy; Bristol Myers Squibb. PARAOXONASES IN INFLAMMATION, INFECTION, AND TOXICOLOGY. Book Series: Advances in Experimental Medicine and Biology Volume: 660, Pages: 113-127 Published: 2010

47. Jakubowski H. The Pathophysiological Hypothesis of Homocysteine Thiolactone-mediated Vascular Disease. 24th Congress of the Polish-Physiological-Society, Lublin Agr Univ, Lublin, POLAND, SEP 11-13, 2008. Sponsor(s): Polish Physiol Soc. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY Volume: 59 Pages: 155-167 Published: DEC 2008

48. Jakubowski H. Paraoxonase 1 (PON1), a junction between the metabolisms of homocysteine and lipids. Edited by: Mackness, B; Mackness, M; Aviram, M; et al. Conference: 2nd International Conference on Paraoxonases, Hajduszoboszlo, HUNGARY, SEP, 2006. PARAOXNASES: THEIR ROLE IN DISEASE DEVELOPMENT AND XENOBIOTIC METABOLISM Book Series: Proteins and Cell Regulation Volume: 6 Pages: 87-102 Published: 2008

49. Jiang X, Yang FF, Brailoiu E, Jakubowski H et al. Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells 32nd Congress of the Federation-of-European-Biochemical-Societies (FEBS) Location: Vienna, AUSTRIA Date: JUL 07-12, 2007. Sponsor(s): Federat European Biochem Soc. FEBS JOURNAL Volume: 274 Supplement: 1 Pages: 271-271 Published: JUL 2007

50. Sikora M, Marczak L, Stobiecki M, Jakubowski H. Determination of N-homocysteinylated albumin in human serum. 32nd Congress of the Federation-of-European-Biochemical-Societies (FEBS), Vienna, AUSTRIA, JUL 07-12, 2007. Sponsor(s): Federat European Biochem Soc. FEBS JOURNAL Volume: 274 Supplement: 1 Pages: 295-295 Meeting Abstract: F1-121, Published: JUL 2007.

51. Jakubowski H. The molecular basis of homocysteine thiolactone-mediated vascular disease. 1st World Congress on Hyperhomocysteinaemia Location: Saarbrucken, GERMANY Date: JUN 05-09, 2007. Clin Chem Lab Med Vol. 45, Issue: 12, Pages: 1704-1716, Published: 2007

52. Jiang X, Yang X-F, Brailoiu E, Jakubowski H, et al. Regulation of homocysteine transport in vascular cells. 48th Annual Meeting of the American-Society-of-Hematology, Orlando FL, DEC 09-12, 2006. Sponsor(s): Amer Soc Hematol. BLOOD Volume: 108, Issue: 11, Pages: 59B-59B Part: 2, Meeting Abstract: 3926 Published: NOV 16 2006.

53. Domagala TB, Lacinski M, Trzeciak WH, Mackness B, Mackness MI, Jakubowski H. (2006) The correlation of homocysteine-thiolactonase activity of the paraoxonase (PON1) protein with coronary heart disease status". 2nd International Conference on Paraoxonases, Hajdúszoboszló, Hungary, September 7-10, 2006 (Invited Speaker).

54. Zimny J, Sikora M, Guranowski A, Jakubowski H. Protective Mechanisms Against Homocysteine Toxicity: The Role of Bleomycin Hydrolase". FASEB SRC on “One Carbon, Folic Acid, and Vitamin B12 Metabolism”, Indian Wells, CA, 5-10 August, 2006

55. Jakubowski H. (2005) Pathophysiological consequences of homocysteine excess. 5 th Amino Acid Assessment Workshop, Beverly Hills, CA (Invited Speaker). Sponsor(s): Int Council Amino Acid Sci. Journal of Nutrition 136(6) Supplement: S Pages: 1741S-1749S Published: Jun 2006

56. Domagala TB, Lacinski M, Trzeciak WH, Mackness B, Mackness MI, Jakubowski H. (2005) The correlation of homocysteine-thiolactonase activity of the paraoxonase (PON1) protein with coronary heart disease status. 4th World Congress of Cellular and Molecular Biology, Poitiers, France. Abstracts Book, p. 55 (Invited Speaker).

57. Jakubowski H. (2005) Mechanism and consequences of protein N-homocysteinylation in humans. 9th International Congress on Amino Acids, Vienna, Austria, Aug 8-12, 2005. (Invited Speaker). Amino Acids (Vienna) Volume: 29 Issue: 1 Pages: 5 Published: JUL 2005

58. Jakubowski H. (2005) Anti N-homocysteinylated protein autoantibodies and cardiovascular disease. 4th Conference on Hyperhomocysteinemia. Saarbruecken, Germany, April 14-16, 2005 (Invited Speaker). Clin Chem Lab Med 2005;43:1011-1014.

59. Zimny J, Iwanowska D, Starzynska E, Jakubowski H, Guranowski A. (2005) Homocysteine thiolactone is a substrate of bleomycine hydrolase/cysteine protease/gal6 protein. 4 th

Conference on Hyperhomocysteinemia. Saarbruecken, Germany, April 14-16. Clin Chem Lab Med 2005;43:A23 (selected for platform presentation).

60. Chwatko G, Jakubowski H. (2005) The detemination of homocysteine-thiolactone in human

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plasma and urine. 4th Conference on Hyperhomocysteinemia. Saarbruecken, Germany. Clin Chem Lab Med 2005;43:A18.

61. Perla J, Twardowski T, Jakubowski H. (2005) Purification of antibodies against N-homocysteinylated proteins by affinity chromatography on N-homocysteinyl-aminohexyl-Agarose. 4th Conference on Hyperhomocysteinemia. Saarbruecken, Germany. Clin Chem Lab Med 2005;43:A29.

62. Jakubowski H. (2004) Molecular basis of homocysteine toxicity in humans. 15th

International Congress of the Polish Pharmacological Society. Poznan, Poland (Invited Speaker).

63. Perla J, Twardowski T, Jakubowski H. (2005) Purification of antibodies against N-homocysteinylated proteins by affinity chromatography on N-homocysteinyl-aminohexyl-Agarose. 15th International Congress of the Polish Pharmacological Society. Poznan, Poland (Invited Speaker)

64. Lacinski M, Skorupski W, Cieslinski A, Trzeciak W, Jakubowski H (2004) Determinants of homocysteine-thiolactonase activity in humans. 1st Intl Paraoxonase Conference. University of Michigan, Ann Arbor, MI (Selected Speaker).

65. Glowacki R, Jakubowski H (2004) Cross-talk between Cys-34 and lysine residues in human serum albumni revealed by N-homocysteinylation. FASEB Summer Research Conference on Folic Acid, Vit. B12, and One Carbon Metabolism. Snowmass, CO.

66. Chwatko G, Jakubowski H. (2004) Urinary excretion of homocysteine-thiolactone in humans. FASEB Summer Research Conference on “Folic Acid, Vit. B12, and One Carbon Metabolism”, Snowmass, CO.

67. Undas A, Perla J, Lacinski M, Trzeciak W, Kazmierski R, Jakubowski, H. (2004) Autoantibodies against N-homocysteinylated-proteins in humans: Implications for atherosclerosis.FASEB SRC on “Folic Acid, Vit. B12, and One Carbon Metabolism”, Snowmass, CO.

68. Jakubowski H. (2004) Homocysteine and cardiovascular disease. 14 th International Congress of the Polish Pharmacological Society. Poznan, Poland (Invited Speaker).

69. Jakubowski H. (2003) Homocysteine thiolactone and homocysteine-N-protein are present in humans: Implications for vascular disease. 4th International Conference on Homocysteine Metabolism. Basel, Switzerland (Selected Speaker)

70. Jakubowski H. (2003) Protein H-homocysteinylation in humans. 3rd Conference on Hyperhomocysteinemia. Saarbruecken, Germany (Invited Speaker)

71. Jakubowski H. (2002) Homocysteine is a protein amino acid. FASEB SRC on “Folic Acid, Vit. B12, and One Carbon Metabolism”, Snowmass, CO.

72. Jakubowski H. (2002) Expansion of the genetic code: Decoding methionine codons by homocysteine. tRNA Synthetase Conference, Asilomar, CA (Selected Speaker).

73. Jakubowski H. (2002) Aminoacylation of coenzyme A by aminoacyl-tRNA synthetases: Possible link between non-coded and coded peptide synthesis. tRNA Synthetase Conference, Asilomar, CA.

74. Jakubowski H. (2001) Determination of homocysteine thiolactone and homocysteine-N-protein in human plasma. 3rd International Conference on Homocysteine Metabolism. Sorrento, Italy (Selected Speaker).

75. Jakubowski H. (2001) Folate, high-density lipoproteins (HDL) and methionine affect incorporation of homocysteine into protein in human endothelial cells. 3rd International Conference on Homocysteine Metabolism. Sorrento, Italy.

76. Jakubowski H, Ambrosius WT, Pratt HJ. (2001) Genetic Determinants of homocysteine thiolactonase activity in humans. 3rd International Conference on Homocysteine Metabolism. Sorrento, Italy (Selected Speaker).

77. Jakubowski H. Homocysteine-thiolactone and S-Nitroso-homocysteine mediate incorporation of homocysteine into protein in humans. 3rd Conference on Hyperhomocysteinemia, Saarbrucken, Germany, 2001. Clin Chem Lab Med Volume: 41 Issue: 11 Pages: 1462-1466 Published: 2003

78. Jakubowski H. (2001) Translational accuracy of aminoacyl-tRNA synthetases: Implications for atherosclerosis. Experimental Biology 2001 Annual Meeting Location: ORLANDO, FLORIDA Date: MAR 31-APR 04, 2001. Orlando, FL (Invited Speaker). Sponsor(s): Amer

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Soc Nutr Sci. Journal of Nutrition 131(11): 2983S-2987S, Published: Nov 2001.79. Jakubowski H. (2000) Calcium-dependent human serum homocysteine thiolactone

hydrolase: A protective mechanism against protein N-homocysteinylation. FASEB Summer Research Conference on Folic Acid, Vit. B12, and One Carbon Metabolism. Snowmass, CO (Invited Speaker).

80. Jakubowski H. (2000) tRNA-dependent incorporation of S-nitrosohomocysteine into protein. 18th Intl tRNA Workshop, Cambridge University, UK (Selected Speaker).

81. Jakubowski H. (2000) Aminoacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase. 18th International tRNA Workshop. Cambridge University, UK.

82. Jakubowski H. (1999) Homocysteine thiolactone: Metabolic origin and protein homocysteinylation. Homocysteine Session of 6th Intl Congress on Amino Acids. Bonn, Germany, August 3-7, 1999 (Session Chair & Invited Speaker). Amino Acids (Vienna) Volume: 17 Issue: 1 Pages: 42 Published: 1999.

83. Jakubowski H. (1999) Protein homocysteinylation: Possible mechanism underlying pa-thological consequences of elevated Hcy levels. Protein Society Meeting. Boston, MA.

84. Jakubowski H, Zhang, L; Bardeguez, A; et al. (1999) Homocysteine thiolactone and protein homocysteinylation in human endothelial cells - Implications for atherosclerosis. 1999 Experimental Biology Meeting, Washington, DC, Apr 17-21, 1999. Circulation Research Volume: 87 Issue: 1 Pages: 45-51 Published: Jul 7, 2000.

85. Jakubowski H. (1999) Homocysteine thiolactone: Metabolic origin and protein homocysteinylation in humans. Annual Meeting of the American Society of Nutritional Sciences, Symposium on Homocysteine in Aging and Geriatric Disease. Washington, DC (Invited Speaker). Sponsor(s): Amer Soc Nutr Sci. Journal of Nutrition Volume 130, Supplement: S, Pages: 377S-381S, Published: Feb 2000.

86. Jakubowski H. (1998) Human serum proteins contain homocysteine bound via amide bonds. 2nd International Conference on Homocysteine Metabolism. Nijmegen, Netherlands, April 26-29, 1998 (Selected Speaker). Netherlands Journal of Medicine, Volume: 52, Issue: SUPPL. Pages: S45, Published: April, 1998.

87. Jakubowski H. (1997) Metabolism of homocysteine thiolactone in human cell cultures: Possible mechanism for pathological consequences of elevated homocysteine levels. 17th International tRNA Workshop. Chiba, Japan.

88. Jakubowski H. (1997) Editing of homocysteine and related thioester chemistry of aminoacyl-tRNA synthetases. 17th International tRNA Workshop. Chiba, Japan.

89. Jakubowski H. (1997) Editing of homocysteine by aminoacyl-tRNA synthetases. Keystone Symposia Conference on Aminoacyl-tRNA Synthetases in Biology and Disease. Taos, NM (Invited Speaker).

90. Jakubowski H. (1996) Deregulation of homocysteine metabolism leads to enhanced synthesis of homocysteine thiolactone in human cells. FASEB Summer Research Conference on Folate, Vit. B12, and One Carbon Metabolism. Saxtons River, VT.

91. Gao W, Jakubowski H, Goldman E. (1995) Evidence that uncharged tRNATrp can inhibit a programmed translational frameshift in Escherichia coli. Molecular Genetics of Bacteria & Phages, CSHL, NY, p.71.

92. Jakubowski H. (1995) Proofreading in vivo: Editing of homocysteine by aminoacyl-tRNA synthetases in E. coli. Molecular Genetics of Bacteria & Phages, CSHL, NY.

93. Jakubowski H. (1995) A model of the synthetic/editing site of an aminoacyl-tRNA synthetase. Molecular Genetics of Bacteria & Phages, CSHL, NY, p. 117.

94. Jakubowski H. (1995) Proofreading in trans by an aminoacyl-tRNA synthetase. 4th Intl Congress on Amino Acids, Vienna, Austria. Amino Acids 9, 6-7. (Selected Speaker).

95. Jakubowski H. (1995) Proofreading in vivo: Editing of homocysteine by isoleucyl- and leucyl-tRNA synthetase in Escherichia coli. 4th Intl Congress on Amino Acids, Vienna, Austria. Amino Acids 9, 7 (Selected Speaker).

96. Jakubowski H. (1995) Synthesis of a peptide bond by an aminoacyl-tRNA synthetase. 4th Intl Congress on Amino Acids, Vienna, Austria. Amino Acids 9, 54 (Selected Speaker).

97. Gao W, Goldman E, Jakubowski H. (1995) Role of carboxy-terminal region in editing function of methionyl-tRNA synthetase in Escherichia coli: Channeling of amino acids from biosynthetic pathway to protein synthesis. 4th Intl Congress on Amino Acids, Vienna,

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Austria. Amino Acids 9, 51 (Selected Speaker).98. Jakubowski H. (1995) A model of the synthetic/editing site of an aminoacyl-tRNA synthe-

tase. 4th Intl Congress on Amino Acids, Vienna. Amino Acids 9, 53 (Selected Speaker).99. Jakubowski H. (1995) Proofreading in trans by an aminoacyl-tRNA synthetase. 16th

International tRNA Workshop. University of Wisconsin, Madison, WI. Abstracts p. 148.100. Jakubowski H. (1995) Proofreading in vivo: Editing of homocysteine by isoleucyl- and

leucyl-tRNA synthetase in Escherichia coli. 16th International tRNA Workshop. University of Wisconsin, Madison, WI. Abstracts p. 149.

101. Jakubowski H. (1995) Synthesis of a peptide bond by an aminoacyl-tRNA synthetase. 16th International tRNA Workshop. University of Wisconsin, Madison, WI. Abstract p. 150.

102. Gao W, Goldman E, Jakubowski H. (1995) Role of C-terminal region in editing function of Met-tRNA synthetase in E. coli: Channeling of amino acids from biosynthetic pathway to protein synthesis. 16th Intl tRNA Workshop. Madison, WI. Abstracts p. 128.

103. Gao W, Jakubowski H, Goldman E. (1995) Evidence that uncharged tRNA can inhibit a programmed translational frameshift in Escherichia coli. 16th International tRNA Workshop, University of Wisconsin. Madison, WI, Abstracts, p. 127.

104. Jakubowski H. (1995) A model of the synthetic/editing site of an aminoacyl-tRNA synthetase. 16th International tRNA Workshop. Univ. of Wisconsin, Madison, WI, Abstracts, p. 82 (Selected Speaker).

105.Jakubowski H. (1995) Synthesis of homocysteine thiolactone in normal and malignant cells. Edited by: Graham, I; Refsum, H; Rosenberg, IH; et al. International Conference on Homocysteine Metabolism: From Basic Science to Clinical Medicine, Dromoland Castle, Co. Clare, Ireland, July 2-6, 1995 (Invited Speaker). Sponsor(s): Medice Co. Book Series: Developments in Cardiovascular Medicine, Pages: 157-165, Published: 1997.

106. Gao W, Goldman E, Jakubowski H. (1995) Channeling assures efficient editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli. International Conference on Homocysteine Metabolism: From Basic Science to Clinical Medicine, Dromoland Castle, Co. Clare, Ireland. Irish Journal Medical Science 164 (suppl. 15), 9.

107. Gao W, Goldman E, Jakubowski H. (1994) Role of carboxy-terminal region in proofreading function of methionyl-tRNA synthetase in Escherichia coli. Molecular Genetics of Bacteria and Phages Meeting. Madison, WI, p. 142.

108. Jakubowski H. (1994) Editing of errors in protein synthesis: Molecular mechanism, cellular and evolutionary implications of the synthesis of homocysteine thiolactone by methionyl-tRNA synthetase. FASEB Summer Research Conference on One Carbon, Folate, and Vitamin B12 Metabolism, Copper Mountain, CO (Invited Speaker).

109. Jakubowski H. (1994) Editing of errors in protein synthesis: Molecular mechanism, cellular and evolutionary implications of the synthesis of Hcy-thiolactone by Met-tRNA synthetase. CSIC Research Workshop on Methionine Metabolism: Molecular Mechanism and Clinical Implications, Sierra Nevada, Granada, Spain.

110. Jakubowski H. (1993) Evolution of a methyl donor function. FASEB Summer Research Conference on Biochemistry and Pharmacology of S-Adenosylmethionine and Methylation. Copper Mountain, CO.

111.Jakubowski H. (1993) Energy cost of translational proofreading in vivo: The aminoacylation of transfer RNA in Escherichia coli. Edited by: Kelly, RM; Wittrup, KD; Karkare, Conference on Biochemical Engineering VIII, Princeton NJ, July 11-16, 1993(Invited Speaker). Sponsor(s): Engn Fdn; Natl Sci Fdn; New York Acad Sci. Biochemical Engineering VIII Book Series: Annals of the New York Academy of Sciences 745;4-20, Published1994

112. Kim HY, Schulman LH, Brunie S, Jakubowski H. (1993) Relationship between synthetic and editing functions of the active site of Escherichia coli methionyl-tRNA synthetase. 15th International tRNA Workshop, Cap D'Agde, France, p. 268.

113. Jakubowski H. (1993) Evolution of a methyl donor function: Functional and structural similarities between Escherichia coli methionyl-tRNA synthetase and S-adenosyl-methionine synthetase. 15th International tRNA Workshop, Cap D'Agde, France, p. 339.

114. Jakubowski H. (1992) Proofreading in vivo: The mechanism and energy cost of editing by methionyl-tRNA synthetase in E. coli. Translational Control Meeting, Cold Spring Harbor,

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NY, p. 140.115. Jakubowski H. (1992) Homocysteine thiolactone and S-methyl-homocysteine thiolactone

are products of an error editing reaction of methionyl-tRNA synthetase. FASEB Summer Research Conference on Folic Acid, Vit. B-12 & One-C Metabolism. Saxtons River, VT.

116. Jakubowski H, Goldman, E. (1991) Repression of the MET3 gene during heat shock leads to cell death in the yeast S. cerevisiae. Yeast Cell Biology, Cold Spring Harbor, NY, p. 88.

117. Cay XY, Jakubowski H, Pan YCE, Brot N, Weissbach H. (1991) Vitamin B12 regulation of metE expression in E. coli. 15th Intl Congress of Biochemistry, Jerusalem, Israel, p. 152.

118. Goldman E, Jakubowski H. (1991) Uncharged tRNA, protein synthesis and the bacterial stringent response. 14th Intl tRNA Workshop. Rydzyna, Poland.

119. Jakubowski H. (1991) Editing of errors in selection of amino acids for protein synthesis. 14th Intl tRNA Workshop. Rydzyna, Poland (Selected Speaker).

120.Goldman E, Jakubowski H. (1991) Uncharged tRNA, protein synthesis, and the bacterial stringent response. Symposium on Translational Control Held at the 20 th Annual Meeting of the Keystone Symposia on Molecular and Cellular Biology, Tamarron, CO, USA. Journal of Cellular Biochemistry, Suppl. 15 Part D, Pages: 178, Published 1991.

121. Jakubowski H. (1991) Proofreading in vivo: Editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli and Saccharomyces cerevisiae. Symposium on Translational Control Held at the 20th Annual Meeting of the Keystone Symposia on Molecular and Cellular Biology, Tamarron, CO, USA. Journal of Cellular Biochemistry, Suppl. 15 Part D, Pages: 179, Published 1991.

122.Jakubowski H. (1990) Proofreading in vivo: Editing of homocysteine by methionyl-tRNA synthetase in E. coli. 90th Annual Meeting of the ASM, Anaheim, CA, May 13-17, 1990. Abstracts of the Annual Meeting of the American Society for Microbiology, Volume: 90 Pages: 185, Published: 1990 (Selected Speaker).

123.Rojiani M, Jakubowski H, Goldman E. (1990) Modulation of protein synthesis in Escherichia coli by uncharged tRNA. 90th Annual ASM Meeting, Anaheim, CA, May 13-17, 1990. Abstracts of the Annual Meeting of the American Society for Microbiology, Volume: 90, Pages: 177, Published: 1990.

124. Jakubowski H. (1989) Proofreading in vivo: Editing of homocysteine by methionyl-tRNA synthetase in E. coli. Translational Control Meeting, Cold Spring Harbor, N.Y., p. 90.

125. Rojiani MV, Jakubowski H, Goldman E. (1989) Effects of varying charged and uncharged tRNATrp on protein synthesis and the stringent response in E. coli. Translational Control Meeting, Cold Spring Harbor, N.Y., p. 101 (Selected Speaker).

126. Rojiani MV, Jakubowski H, Goldman E. (1989) Effects of varying charged and uncharged tRNATrp on protein synthesis and stringent response in E. coli. ASM Conference on Ribosomes. East Glacier Park, Montana, p. 31.

127.Jakubowski H, Goldman E. (1989) Cooperation between cells during sporulation of the yeast Saccharomyces cerevisiae. 89th Annual ASM Meeting, New Orleans, LA, May 14-18, 1989. Abstracts of the Annual Meeting of the American Society for Microbiology, Volume: 89 Pages: 223, Published: 1989.

128. Jakubowski H. (1989) Editing of noncognate amino acids in Escherichia coli. 13th International tRNA Workshop, Vancouver, Canada. Abstract #TU-39.

129. Rojiani MV, Jakubowski H, Goldman E. (1989) Effects of varying charged and uncharged tRNATrp on protein synthesis and the stringent response in E. coli. 13th International tRNA Workshop, Vancouver, Canada. Abstract #WE-am-12.

130. Jakubowski H. (1987) Cell density-dependent interactions in yeast sporulation. CSHL Meeting on "Yeast Cell Biology," Cold Spring Harbor, NY, p. 48.

131. Jakubowski H. (1987) Negative correlation between the abundances of Escherichia coli aminoacyl-tRNA families and their affinities for elongation factor Tu-GTP. 12th Intl tRNA Workshop, Umea, Sweden. Abst. #IVd-7.

132.Jakubowski H. (1987) Conditional sporulation deficient phenotype of yeast adenine auxotrophs: de novo purine synthesis is required for sporulation. ASBC 78th Annual Meeting, Philadelphia, PA. Federation Proceedings 46, 2217-2117. Published: May 1, 1987

133. Jakubowski H. (1985) Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized during sporulation of yeast Saccharomyces cerevisiae. Nature's Fifth

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International Conference on "Genes and Systems in Development", San Francisco, CA.134. Jakubowski H, Guranowski A. (1985) Half-of-the-site reactivity of plant S-adenosyl-

homocysteinase. An International Symposium on "The Biochemistry of S-adenosylmethionine as a Basis for Drug Design", Bergen, Norway.

135.Jakubowski H. (1985) Correlation between abundances of Escherichia coli aminoacyl-tRNA families and their affinities for elongation factor Tu-GTP. FASEB Meeting, Anaheim, CA, Federation Proceedings 44, 1799-1799. Published: 1985

136. Jakubowski H, Goldman E. (1984) Quantities of individual aminoacyl-tRNA families and their turnover in Escherichia coli. Bacteriophage Meeting, Cold Spring Harbor, NY.

137. Goldman E, Jakubowski H. (1984) Quantities of aminoacyl-tRNA in Escherichia coli. ASBC/AAI Meeting, St. Louis, MO. Federal Procedure 43, 1482, Abst. #387.

138. Jakubowski H. (1984) Why spermine in eucaryotes? ASBC/AAI Meeting, St. Louis, MO. Federation Proceedings 43, 2020, Abst. #3502.

139. Jakubowski H, Guranowski A. (1984) Synthesis and degradation of AppppA and other bisnucleoside oligophosphates in higher plants. 51st Conference of Gesellschaft fur Biologische Chemie on "Metabolism of Diadenosine Tetraphosphate", Regensburg, Germany. Hoppe-Seyler's Z. Physiological Chemistry 365, 599-600 (Selected Speaker).

140. Koontz S, Jakubowski H, Goldman E. (1983) Control of bacteriophage MS2 RNA and pro-tein synthesis by Trp-tRNATrp. l5th FEBS Meeting, Bruxelles, Belgium, p 241.

141. Jakubowski H, Guranowski A. (1983) Enzymes hydrolyzing diadenosine triphosphate and/or diadenosine tetraphosphate in higher plants. 74th Annual ASBC Meetings, San Francisco, CA. Abst. #2547.

142. Jakubowski H, Goldman E. (1983) Elevated tRNA-Trp levels in an E. coli mutant with altered Trp-tRNA synthetase. 10th Intl tRNA Workshop, Hakone, Japan, p. B-37.

143. Jakubowski H. (1983) Synthesis of dinucleoside 5',5'''-P1,P4-triphosphates by plant (Lupinus luteus) seryl-tRNA and phenylalanyl-tRNA synthetases. 10th Intl tRNA Workshop, Hakone, Japan.

144.Jakubowski H. (1982) The polyamine specificity of the tRNA aminoacylation reaction catalyzed by procaryotic (Escherichia coli) and eucaryotic (plant, Lupinus luteus) valyl-tRNA synthetases. 41st Bat-Sheva Seminar on "Polyamines in Growth and Differentiation Processes", Kiryat Anavim, Jerusalem, Israel, July 4-9, 1982 (Selected Speaker). XXIV+808P. Raven Press: New York, NY, USA. Illus Book Series: Advances in Polyamine Research, Pages: 307-320, Published: 1983

145. Jakubowski H. (1980) Valyl-tRNA synthetase from yellow lupine seeds: Hydrolysis of the enzyme bound noncognate aminoacyl adenylate as a possible mechanism of increasing specificity of the aminoacyl-tRNA synthetase. Intl Meeting on "Biological Implications of Protein-Nucleic Acid Interactions", Dymaczewo near Poznan, Poland.

146. Jakubowski H. (1978) Valyl-tRNA synthetase from yellow lupine seeds: Instability of the enzyme bound noncognate adenylate vs. cognate adenylate. 12th FEBS Meeting, Dresden, East Germany.

147. Pastuszyn A, Jakubowski H, Loftfield RB. (1976) Dual mechanism of aminoacylation of tRNA. 67th ASBC Meeting, San Francisco, CA. Federation Proceedings 35, 1968.

148. Jakubowski H, Pawelkiewicz J. (1976) Interpretation of incomplete aminoacylation of transfer RNA. 67th Annual ASBC Meeting, San Francisco, CA. Fed. Proc. 35, 1968.

149. Wierzbicka H, Jakubowski H, Pawelkiewicz J. (1974) tRNA methyltransferases from yellow lupine seeds: Purification & properties. 10th FEBS Meeting, Budapest, Hungary.

150. Jakubowski H, Pawelkiewicz J. (1974) Purification and characterization of valyl-tRNA, tryptophanyl-tRNA, and seryl-tRNA synthetases from yellow lupine seeds. 10th FEBS Meeting, Budapest, Hungary.

F. Reports

1. Undas A, Jakubowski H. Letter Regarding Article by Menon V, Sarnak MJ Greene T, et al. Relationship between homocysteine and mortality in chronic kidney disease (Circulation 2006;113:1572-7). Circulation 2006;114(16):e547.

2. Jakubowski H. Comments regarding fraud in science. Nature Newsblog, June 6, 2006 (http://blogs.nature.com/news/blog/2006/05/fraud.html

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http://blogs.nature.com/news/blog/2006/05/fraud.html

3. Jakubowski H. Relationships between autoantibodies against N-homocysteinylated proteins, homocysteine, and stroke in humans. International Artheriosclerosis Society, Commentaries, July 2004 (http://www.athero.org)

4. Jakubowski H. On the health benefits of Allium sp. Nutrition 19, 167-168.5. Jakubowski H. Protein N-homocysteinylation in humans. Clinical Chemistry, eLetters July

2002.6. Guranowski A, Jakubowski H. (1984) Report from 1984 conference on "Metabolism of

Diadenosinetetraphosphate". Postepy Biochemii 31, 207-209.7. Jakubowski H. (1983) Report from 1983 Nature's Conference "30 years of DNA". Postepy

Biochemii 30, 201.

PRESENTIONS:A. Scientific (Basic Science):

Invited Talks at International Meetings

2020: “Homocysteine Editing and the Risk of Acute Myocardial Infarction in Coronary Artery Disease Patients; the WENBIT trial.” FASEB Summer Res. Conf. on Folic Acid, Vitamin B12, and One Carbon metabvolism, venue & date TBD.2016: Evolution of the Translational Apparatus: Implications for the Origin and History of

the Genetic Code, Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA Nov 13-16.

2015: 14th Intl Congress on Amino Acids, Peptides and Proteins. Vienna, Austria, Aug 3-72014: Polish Institute of Arts and Sciences in America (PIASA) Congress, Warsaw, Poland, June 20-23 (talk on “Beyond Cholesterol - Emerging Cardiovascular Risk Factors:

A Personal Account from the US and Poland”)2013: 13th Intl Congress on Amino Acids, Peptides and Proteins. Galveston, TX, USA, Oct. 5-7 2013: 9th International Conference on Homocysteine and One-carbon Metabolism, Dublin,

Ireland, September 8-122013: International Symposium on Biological Functions of Pantothenic Acid: PantothenicAcid and the Brain, New Opportunities in Metabolic and Dietary Therapy, Grodno, Belarus,Jun28-29.2012: Polish-German Biochemical Societies Joint Meeting, Poznan, September 11-142012: FASEB Summer Res. Conf. on Folic Acid, Vitamin B12, and One Carbon Substances,

Kolimbari, Crete, Greece, July 22-272012: 25th International Symposium on the Organic Chemistry of Sulfur, Czestochowa,

Poland, June 24-29, 2012 2012: Advances and Controversies in B-Vitamins & Choline, Leipzig, Germany, March 5-82011: 2nd Polish Congress of Biochemistry and Cell Biology, Krakow, Sept. 5-9 2011: 8th Conference on Homocysteine Metabolism, Lisbon, Portugal, June 19-232010: 4th Intl Conference on Paraoxonases. La Pineda, Vilaseca, Catalonia, Spain, Sept. 7-102009: 7th Conference on Homocysteine Metabolism, Prague, Czech Republic, June 21-252008: International Congress of the Polish Physiological Society, Lublin, Sept. 11-132008: 3rd Intl Conference on Paraoxonases, UCLA, Los Angeles, CA, Sept. 7-102007: 6th Conference on Homocysteine Metabolism, World Congress on

Hyperhomocysteinemia, Saarbruecken, Germany, June 5-92006: 2nd International Conference on Paraoxonases, Hajdúszoboszló, Hungary, Sept 7-10

2005: 4th World Congress on Cellular and Molecular Biology, Poitiers, France, Oct 8-13 2005: 5th Amino Acid Assessment Workshop, The Beverly Hilton, Los Angeles, CA, Oct 22-242005: 9th International Congress on Amino Acids and Proteins, Vienna, Austria, Aug 3-82005: 4th Conference on Hyperhomocysteinemia, Sarbrücken, Germany, April 14-162004: 1st Intl Paraoxonase Conference, University of Michigan, AnnArbor, MI, April 4-72004: 16th International Congress of the Polish Pharmacological Society, Poznan, Poland2003: 4th International Homocysteine Conference, Basel, Switzerland2003: 3rd Conference on Hyperhomocysteinemia, Sarbrücken, Germany2002: Aminoacyl-tRNA Synthetases in Biology, Medicine, and Evolution, Asilomar, CA2001: ASNS Symposium on Translational Control, Experimental Biology, Orlando, FL2001: 3rd International Homocysteine Conference, Sorrento, Italy2001: 14th International Congress of the Polish Pharmacological Society, Krakow, Poland

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http://www.athero.org/

2000: FASEB Summer Res. Conf. on 1C, Folate, & Vit. B12 Metabolism, Snowmass, CO2000: 18th International tRNA Workshop, Cambridge, UK1999: ASNS Homocysteine Symposium, Experimental Biology 99, Washington, DC 1999: 6th International Congress on Amino Acids, Bonn, Germany1998: 2nd International Homocysteine Conference, Nijmegen, Netherlands1997: Keystone Symposia on Aminoacyl-tRNA Synthetases in Biology& Disease, Taos, NM 1996: 16th International tRNA Workshop, University of Wisconsin, Madison, WI1995: 1st Intl Homocysteine Conference, Dromoland Castle, Co. Clare, Ireland1995: 4th International Amino Acids Congress, Vienna, Austria1994: FASEB Summer Res. Conf. on 1C, Folate, & Vit. B12 Metabolism, Copper Mtn, CO1993: Biochemical Engineering Meeting, Princeton, NJ1991: 14th Intl tRNA Workshop, Rydzyna, Poland1990: America Society for Microbiology Meeting, Anaheim, CA1984: 51st Conference of Gesellschaft für Biologische Chemie on "Metabolism of Diadenosine Tetraphosphate", Regensburg, Germany1982: Bat-Sheva Seminar on "Polyamines in Growth and Differentiation Processes", Kibbutz Kiryat Anavim near Jerusalem, Israel.

Invited Seminars

2019: Centro de Investigaciones Biológicas (CSIC), Madrid, Spain, June 14.2016: Department of Nutritional Sciences, Rutgers University, Piscataway, NJ, October 202016: Department of Nutrition Science, University of Life Sciences, Poznan, May19 2014: Molecular and Biomolecular Research Center PAS, Lódz, November 142014: Department of Environmental Chemistry, Lódz University, November 13, 20142014: Department of Bioorganic Chemistry, Wroclaw University, November 7, 2014 2014: Institute of Human Genetics, Poznań, May 27, 2014 2013: Department of Chemistry, Brooklyn College, Brooklyn, NY, December 6, 20132013: Polish Institute of Arts and Sciences in America, Manhattan, NY, February 18, 20132012: St. Thomas Hospital, Centre for Haemostasis & Thrombosis, London, July 3, 20122012: Department of Biochemistry, Gdansk University, Poland, March 19, 20122011: Faculty of Chemistry, Lodz University, Lodz, Poland2011: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lódź, Poland2011: Department of Food Technology, Life Sciences University, Poznań2010: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland2010: Faculty of Chemistry, Lodz University, Lodz, Poland2010: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lódź, Poland2009: Department of Chemistry, Portland State University, Portland, OR, USA2008: Department of Food Technology, Life Sciences Uniwersity, Poznań2007: Institut National de la Recherche Agronomique, Nantes, France.2006: Department of Pharmacology, Temple University, Philadelphia, PA2006: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań2006: Clinic for Special Children, Strasburg, PA2005: Department of Microbiology and Molecular Genetics, Ohio State University, Columbus, OH2003: Div. of Human Nutr. & Epidemiology, Wageningen University, The Netherlands2003: Institut de Biologie Moleculaire et Cellulaire du CNRS, Strasbourg, France2003: Institute of Biochemistry and Biophysics, Warsaw, Poland2003: Department of Chemistry, Bialystok University, Poland 2003: Institute of Human Nutrition, Warsaw, Poland2003: Department of Medicine, Jagiellonian University, Kraków, Poland2003: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań2003: Department of Neuroscience, University of Siena, Italy2000: Department of Medicine, Jagiellonian University, Kraków, Poland2000: Department of Biochemistry, Merck, Edison, NJ2000: Department of Medicine, Manchester Royal Infirmary, Manchester, UK2000: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań1998: Department of Genetics, Leiden University, The Netherlands

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1996: Department of Microbiology, Stellenbosch University, South Africa1996: Department of Chemistry, City College of New York, City University of New York, NY1995: Department of Biochemistry, St. John’s University, Brooklyn, NY1993: Institut National de la Recherche Agronomique, Nantes, France.1993: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.1993: Department of Biochemistry, Medical Sciences University, Poznań1991: Department of Biochemistry, Agricultural University, Poznań1983: Mitsubishi Research Institute, Tokyo, Japan1981: Department of Biochemistry, Bayreuth University, Germany1981: Institut fur Physiologische Chemie, Erlangen University, Germany1981: Max-Planck-Institut fur Experimentelle Medizin, Abteilung Chemie, Gottingen, Germany 1981: Institute for Biophysics and Physical Biochemistry, Regensburg University, Germany

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