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CURRICULUM VITAE

NAME: Chen Liu, MD, Ph.D.

PRESENT TITLE: Professor and Chairman, Chancellor Scholar

Department of Pathology, Immunology and Laboratory Medicine

New Jersey Medical School

Professor and Chairman

Department of Pathology and Laboratory Medicine

Robert Wood Johnson Medical School

Chairman, Center for Dermatology (Department of Dermatology)

Robert Wood Johnson Medical School

Chief of Service, NJMS University Hospital in Newark and RWJ

University Hospital in New Brunswick

Chief, Division of Oncological Pathology

Cancer Institute of New Jersey

Rutgers University, New Jersey, USA

OFFICE ADDRESS: Rutgers – New Jersey Medical School

185 South Orange Avenue, MSB C 671

Newark, NJ 07103

Rutgers – Robert Wood Johnson Medical School

One Robert Wood Johnson Place, MEB 212

New Brunswick, NJ 08901

E-MAIL ADDRESS:

[email protected]

CITIZENSHIP: USA

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EDUCATION:

A. Undergraduate Graduate and Professional

Tong Liao Medical College (Inner Mongolia University of Nationality),

Tong Liao, China

Degree (Discipline): B.M./M.D. (Medicine) Date Awarded: July, 1985

B. Graduate and Professional

University of Pennsylvania School of Medicine, Philadelphia, PA

Degree (Discipline): Ph.D. (Pathology) Date Awarded: December, 1993

POSTGRADUATE TRAINING:

A. Internship and Residencies

Hahnemann U. Hospital, Philadelphia, Pennsylvania

Anatomical and Clinical Pathology

01/01/1996 to 06/30/1999

UT MD Anderson Cancer Hospital, Houston, Texas

Surgical Oncological Pathology

07/01/1999 to 06/30/2000

B. Postdoctoral Appointments

Scripps Clinic, La Jolla, California

Oncovirology

01/01/1994 to 12/31/1995

ACADEMIC APPOINTMENTS:

Department of Pathology, Immunology and Laboratory Medicine

Rutgers - New Jersey Medical School

Professor and Chair, Tenured

2015 – Present

Department of Pathology and Laboratory Medicine


Professor and Chair, Tenured

2015 – Present

Center for Dermatology


Professor and Chairman

2017 – Present

Department of Pathology and Immunology, Laboratory Medicine

University of Florida

Associate Chair

2012 – 2015

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Department of Pathology and Immunology, and Laboratory Medicine


Professor (Tenured)

2010 – 2015

Department of Pathology, Immunology, and Laboratory Medicine


Endowed Chair in Gastrointestinal and Liver Research

2008 – 2015



Associate Professor (Tenured)

2006 – 2015



Assistant Professor

2000 – 2015

HOSPITAL APPOINTMENTS:

University Hospital

Attending Physician

December 2015 – Present

Robert Wood Johnson University Hospital

Attending Physician

December 2015 – Present

Newark Beth Israel Medical Center

Attending Physician

December, 2017 - Present

University of Florida Shands Hospital

Attending Physician

July 2000 – November 2015

MD Anderson Cancer Center, University of Texas,

Clinical Fellow

July 1999 – June 2000

MCP Hahnemann University Hospital

House Staff

January 1996 – June 1999

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OTHER EMPLOYMENT OR MAJOR VISITNG APPOINTMENTS: None

LICENSURE: Medical License #ME80099 State of Florida. Expire: Jan 31, 2020

Medical License #25MA09724000 State of New Jersey. Expire: June 30, 2021

DRUG LICENSURE:

CDS: N/A

DEA: N/A

CERTIFICATION: American Board of Pathology, AP/CP, indefinite (No expiration)

MEMBERSHIPS, OFFICES AND COMMITTEE ASSIGNMENTS IN

PROFESSIONAL SOCIETIES:

College of American Pathologists (CAP)

Lifetime Fellow

2000 - Present

Association of Pathology Chairs (APC)

Council, Chair-Practice and Management Committee

2019 - Present

American Association for the Study of Liver Diseases (AASLD)

2000 - Present


Member

2012 - Present

American Gastroenterology Association (AGA)

Member and nomination committee

2000 - Present

American Society of Investigative Pathology (ASIP)

Member

2002 - Present

United States & Canadian Academy of Pathology (USCAP)

Member

2003 - Present

Hans Popper Hepatopathology Society

Member and Educational Committee

2005 - Present

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Rodger Haggitt Gastrointestinal Pathology Society

Member

2005 - Present

American Association for Cancer Research (AACR)

Member

2009 - Present

HONORS AND AWARDS:

Faculty of the year, Rutgers University 2019

Alpha Omega Alpha member 2017

Technology Innovator Award, University of Florida 2015

University of Florida Research Foundation Professorship 2014

Technology Innovator Award, University of Florida 2013

Pathology Resident Teaching Award, University of Florida 2011

Howard Hughes Medical Institute Undergraduate Mentor Award 2010

Mid-career Mentor Award, National Institute of Health 2009

Liver Research Scholar, American Liver Foundation 2002

Clinical Fellow Research Award, M.D. Anderson Cancer Center 1999

Award from Gastrointestinal Pathology Society 1998

House Staff Research Award, MCP Hahnemann University 1997

Individual National Research Award, National Cancer Institute, NIH 1994

Scientific Merit Award, Ministry of Health, China 1988

Honored Outstanding Medical Graduate, Tong Liao Medical College 1985

BOARDS OF DIRECTORS/TRUSTEES POSITIONS:

Member, Board of Trustee, Rutgers Health

2016 - Present

Board of Governors, Robert Wood Johnson Medical School

2016 – Present

Board of University Physicians, New Jersey Medical School

2015 – Present

Chair, Board of Trustee, Chinese Hua-Gen School, Gainesville, Florida

2008 – 2011

SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS,

COMMITTEES:

Member of National Institutes of Health Study Sections (ad hoc): 2003, 2005, 2006,

2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019

NIH Clinical Oncology Study Section (CONC, Regular Member) 2015-2021

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SERVICE ON MAJOR COMMITTEES:

A. International:

American Association for the Study of Liver Diseases (AASLD)

Basic Science Committee

2004 - 2008

American Gastroenterology Association (AGA)

Nomination Committee

2011 - 2014

Hans Popper Hepatopathology Society

Educational Committee

2010 - 2013

B. National:


Council, Chair-Practice and Management Committee

2019 – Present

Annual Princeton Integrated Pathology Symposium (PIPS)

Advisory Committee

2013 – Present

Alpha-1 Foundation

Member of Tissue Bank Committee,

2005 – 2008.

C. Medical School/University:

Clinical Leadership Committee, Robert Wood Johnson Medical School

2015 – Present

Chairs Committee, Rutgers Health

2016 – Present

Academic Affair Committee of Faculty Senate


2010 – 2014

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D. Hospital:

Medical Executive Committee, University Hospital

2015 – Present

Medical Executive Committee, RWJ University Hospital

2015 - Present

IT and LIS Steering Committee

University of Florida Shands Hospital

2013 - 2015

E. Department:

University of Florida Department of Pathology, Immunology and Lab

Medicine

Faculty Search Committee

2011 – 2015

Patient outcome and population research committee

2013 - 2015

F. Editorial Boards:

Associate Editor, Laboratory Investigation (USCAP Official Journal)

2010 – Present

Editorial Board, Archives of Pathology &Laboratory Medicine

Section Editor: Precision Medicine

(College of American Pathologists Official Journal) 2014 – Present

G. AdHoc Reviewer:

J. Virology 2002 to present

Hepatology 2004 to present

Gastroenterology 2006 to present

Oncogene 2008 to 2009

American J. Pathology 2004 to present

Human Pathology 2010 to present

Cancer Research 2010 to 2011

J. Infectious Disease 2012 to 2014

Modern Pathology 2011 to present

PlosOne 2013 to present

Plos Pathogen 2012 to present

SERVICE ON GRADUATE SCHOOL COMMITTEES: None

SERVICE ON HOSPITAL COMMITTEES:

See Service on Major Committees, D.

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SERVICE TO THE COMMUNITY:

Member of Advisory Board, Eastside High School, Gainesville, Florida

2011 – 2015

Chair, Board of Trustee, Chinese Hua-Gen School, Gainesville, Florida

2008 – 2011

SPONSORSHIP (Primary Mentorship) OF CANDIDATES FOR

POSTGRADUATE DEGREE:

Jennifer Bess (Immunology and Microbiology, UF) PhD. 2004 – 2009

Erika Eksioglu (Immunology and Microbiology, UF) PhD. 2005 – 2010

Thin Le (Immunology and Microbiology, UF) PhD. 2010 – 2014

Aesis Luna (Biomedical Science, Rutgers) PhD. 2016 – Present

Saiaditya Badeti (Biomedical Science, Rutgers)

MD. Ph.D 2018-present

SPONSORSHIP (Primary Mentorship) OF POSTDOCTORAL FELLOWS:

Olorunseun Ogunwobi, Ph.D, Postdoctoral fellow 2009 – 2014

Elaine Salazar, M.D., Postdoctoral fellow 2011 – 2012

Hongyan Liu, Ph.D., Postdoctoral fellow 2007 – 2011

Frank Zhao, Ph.D., Postdoctoral fellow 2007 – 2012

Houda Darwiche, Ph.D., Postdoctoral fellow 2009 – 2011

Liping Sun, Ph.D. Postdoctoral fellow 2009 – 2011

Jun Hu, M.D., Postdoctoral fellow 2011 – 2012

Rafal Witak, Ph.D., Postdoctoral fellow 2005 – 2007

John Elyar, Ph.D., Postdoctoral fellow 2003 – 2006

Jane Dong, Ph.D., Postdoctoral fellow 2005 – 2007

Qi Su, M.D., Ph.D., Postdoctoral fellow 2005 – 2006

Chaohui Zuo, M.D., Postdoctoral fellow 2014 – 2015

William Puszyk, Ph.D., Postdoctoral Fellow 2009 – 2011

Kien Pham, Ph.D. Postdoctoral fellow 2013 – present

Frank Wu, Ph.D. Postdoctoral fellow 2014 – present

TEACHING RESPONSIBILITIES: A. Lectures or Course Directorships

Rutgers University

GI-Liver section for 2nd year-medical students 2016 –Present

GI-Liver Pathology Fellowship, Co-Diector 2018 –Present


Fellowship Director, Gastrointestinal and Liver Pathology 2004 – 2015

Pathology Resident Teaching 2000 – 2015

Teaching Director, Molecular Pathology 2001 – 2008

Course Director, Systemic pathology:

GI-Liver section for 2nd year-medical students (40 hrs per year) 2003 – 2010

Mentor, IDP graduate program at the University of Florida 2002 – 2015

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Mentor, NIH-T32 training program in Autoimmunity 2005 – 2015

Mentor, NIH-T32 training program in Cancer Biology 2008 – 2013

Lecture Graduate school:

Courses: Liver pathophysiology (10 hrs per year) 2001 – 2012

Mechanisms of Oncogenesis (6 hrs per year) 2009 – 2015

CLINICAL RESPONSIBILITIES: As the Chair of the Department of Pathology, Immunology and Laboratory Medicine, I

oversee the day-to-day operations of the entire department in both Newark and New

Brunswick as well as other locations.

As the Chief of Service for Gastrointestinal and Liver Pathology Service at University

Hospital in Newark, I provide pathology specialty service, consultation service for

patients and clinical practitioners, and administration. As a well-recognized GI/liver

pathologist I also provide a large number of expert consultations for many

physicians/patients.US

GRANT SUPPORT:

Active: A. Principal Investigator

1. NIH, NIDDK, R01DK110024-01, Liu & Robertson (MPI)

Epigenetic Mechanisms Underlying Hepatitis C-Induced

Hepatocarcinogenesis

The major goal of this project is to define changes to the epigenome

and transcriptome in HCV infection and HCV-associated

carcinogenesis.

09/30/2017-06/30/2021

2. NIH, NIAAA, R01 AA027179-01, Liu & Robertson (MPI)

Epigenetic Heterogeneity as a Driver of Liver Disease and Cancer

The major goal of this project is to define how epigenomic

heterogeneity plays a role in alcohol and HCV-associated liver

diseases and cancer.

08/15/2018-05/31/2023

3. Clinical trial: Epigenomics Inc. www.clinicaltrials.gov

Trial Number: NCT03218423

Colon cancer screening using Epi ProColon test based on circulating

DNA methylation

1/15/2018 – 1/14/2021

http://www.clinicaltrials.gov/

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B. Co-Investigator

1. R01 HL125571, National Institute of Health Hanash (PI)

“Regulation of the intestinal stem cell compartment after

hematopoietic transplantation”

07/01/2015-04/30/2020

2. R01 HL124112, National Institute of Health Jenq (PI)

“Microbiota-focused strategies to mitigate GVHD”

08/15/2015-05/31/2020

3. R01 AI118305, National Institute of Health, Yu (PI)

“MicroRNA Regulates Graft-versus-Host Disease”

08/01/2015-01/31/2020

5. 2P30CA72720-20 , NIH/NCI

“ Cancer Center Support Grant (CCSG)”, Libutti (PI)

03/07/2019-02/29/2024

Director, Biospecimen and Histopathology Core

6. UL1TR003017, National Institute of Health, Panettieri (PI)

“Clinical and Translational Science Award (CTSA)”

03/11/19-02/29/2024

Director, Pilot Development Core Program

Completed:

1. National Institute of Health, R01 NCI

Principal Investigator

“Molecular targets for liver cancer diagnosis and therapy”

06/01/2009 – 08/31/2016

2. James &Ester King Biomedical Research Program


"Small molecule inhibitors for Alppha-1 antitrypsin deficient

treatment"

05/25/2015 – 05/24/2018

3. R01 National Institute of Health, R01 NIAAA


“Developmental pathways, environmental agents, and epigenetics in

liver disease”

09/20/2011 – 07/30/2017

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Co-Investigator

"Cellular and Molecular Studies of Bone Marrow Transplants"

07/01/2010 – 04/30/2015

5. National Institute of Health, R01 NIAAA

Co-Investigator

“Acute Alcohol and Calcium-Dependent LPS-Triggered Activation of

Microphages”

09/01/2009 – 08/31/2014

6. University of Florida Research Foundation

Experimental models for human pancreatic cancer

05/01/2014 – 02/28/2016

Role: PI

7. Hamner Institute


“Hepatic Tissue Registry”

05/01/2014 – 04/30/2017


Co-Investigator

"TH1/TH17 cell differentiation in GVHD and GVL"

06/01/2010 – 04/30/2015

9. American Association for Cancer Research

Mentor

“Mechanisms of metastasis in pancreatic cancer”

03/01/2012 – 02/28/2014

10. National Institute of Health, K24 NCRR


“Mouse Immunopathology”

04/01/2009 – 12/31/2014

11. National Institute of Health, R01 NIAID


"Innate and adaptive immune response in HCV patients"

04/01/2005 – 03/31/2011

12. University of Florida Cancer Center


Team Science Project: “Immunotherapy for Liver Cancer”

Total 4 projects and 6 project leaders

01/10/2012 – 02/28/2014

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13. Juvenile Diabetes Research Foundation

Co-Investigator

“Organ Processing and Pathology Core”

12/01/2006 – 12/31/2017

14. R01 CA173878, National Institute of Health Reddy (PI)

"Role of noncoding RNA in Regulating GVHD"

03/01/2013-05/28/2019

15. Bayer Testing Group

Co-Investigator

“Bayer testing services agreement”

02/01/2013 – 12/31/2015



"Nanozymes in cancer therapy"

07/01/2010 – 06/30/2012

17. National Institute of Health, R01 NHLBI

Co-Investigator

"Gene Therapy Using Viral Vector for Lung and Cardiovascular

Disease"

09/01/2008 – 06/30/2013

18. National Institute of Health, NCI


"TCGA program: Pathogenesis of hepatocellular carcinoma"

09/01/2010 – 08/31/2013

19. National Institute of Health, R01 NIDDK

Co-Investigator

"Transduction of hepatocytes with rAAV for correction of genetic

abnormalities"

08/01/2006 – 07/31/2011

20. UF/Moffitt Cancer Center


“Immunotherapy for liver cancer”

2009 – 2010

21. Florida Legislature 00079010


"Adaptive Cell Therapy for Liver Cancer Using Bone Marrow

Transplantation Platform"

03/01/2009 – 03/31/2011

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22. BANYAN BIOMARKERS, Inc.

Co-Investigator

" Liver Serodiagnostic Panel of Liver Inflammation and Fibrosis in

Patients."

2008 – 2010

23. National Institute of Health, NHLBI


“Small molecules to treat alpha-1 antitrypsin deficiency”

2005 – 2008

24. Alpha-one Foundation


“Therapeutic small molecules for alpha-1 antitrypsin deficiency”

2007 – 2009

25. Geyer Foundation for Cancer Research


“Liver Cancer Biomarkers”

2008 -- 2009

26. National Institute of Health, R21, NIAID


“Murine model for hepatitis C virus”

2005 – 2008

27. National Institute of Health, K08 NIDDK


“Role of liver cytokine expression in hepatitis C viral infection”

2002 – 2007

28. Florida Biomedical Research Program

Co-Principal Investigator

Biomarker discovery of liver cancer.

2007 – 2008

29. National Institute of Health, R03 NIDDK


“Role of SOCS3 in Interferon Resistance”

2005 – 2008

30. CellzDirect Corporation (Invitrogen Inc.)


“Hepatic Registry Program.”

2005 – 2007

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31. Howard Hughes Medical Institute


Startup Program

2000 – 2002

32. Howard Hughes Medical Institute


Pilot Project

2000 – 2003



Opportunity research fund

2002 – 2003

34. American Liver Foundation


“Establishment and characterization of PiZZ liver cell lines.”

2003 – 2005

35. American Liver Foundation


Liver scholar award

2002 – 2005

36. Children’s Miracle Network


“Novel treatment for hepatoblastoma.”

2005 – 2006

37. Wyeth Research

Co-Investigator

"A randomized, open-label, comparative evaluation of conversion

from calcineurin inhibitor treatment to Sirolimus treatment versus"

2003 -- 2007

PUBLICATIONS:

A. Refereed Original Article in Journal

1. Liu C, Condreay LD, Burch JB, Mason WS (1991)

Characterization of the core promoter and enhancer of duck

hepatits B virus. Virology 184:242-252. PMID: 1871970

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2. Mason WS, Cullen J, Saputelli J, Wu TT, Liu C, London WT,

Lusterbader E, Shaffer P, O’connell, Aldrich CE, Jilbert AR

(1994) Characterization of the antiviral effects of

2’carbodeoxyguanosine in duck chronically infected with duck

hepatitis B virus Hepatology 19:398-411. PMID: 8294097

3. Liu C, Mason WS, Burch JBE (1994) Identification of factor

binding sites in duck hepatitis B virus and in vivo effects of

enhancer mutations. Journal of Virology. 68:2286-2296. PMID:

8139013

4. Liu C, Smith BC, Nicolaou BM, Vogt P (1996) Sequence selective

carbohydrate DNA interaction: Dimeric and monomeric forms of

the calicheamicin aryltetrasacchride interfere with transcription

factor function. Proceeding of National Academy of Science.

U.S.A, 93:940-944. PMID: 8570664

5. Guo JT, Liu C, Mason WS, Pugh JC (1998) Cloning and

expression of a cDNA encoding the large subunit of duck

replication factor C. Biochimica et Biophysica Acta 1395:293-300.

PMID: 9512663

6. Ayala G, Liu C, Nicosia R (2000) Microvasculature and VEGF

expression in cartilaginous tumors. Human Pathology. 31:341-346.

PMID: 10746677

7. Guo JT, Zhou H, Liu C, Aldrich C, Saputelli J, Whitaker T,

Barrasa I, Mason WS, Seeger C. (2000) Viral clearance and

hepatocyte turnover during hepatitis B infection in woodchucks.

Journal of Virology. 74:1495-1505. PMID: 10627561

8. Reddy P, Teshima T, Lowler K, Kukuruga M, Liu C, Cooke K,

Ferrara J (2001) Interleukin-18 regulates acute graft versus host

disease by enhancing Fas mediated donor T cell apoptosis. Journal

of Experimental Medicine. 194:1433-1440. PMID: 11714750

9. Teshima T, Liu C, Lowler KP, Dranoff G, Ferrara J. (2002) Donor

leukocyte infusion from immunized donors increases tumor

vaccine efficiency after allogenic bone marrow transplantation.

Cancer Research. 62:796-800. PMID: 11830535

10. Teshima T, Reddy P, Lowler K, Kukuruga M, Liu C, Cooke K,

Ferrara JM (2002) Flt3 ligand modulates immune responses

through expansion of CD8 + dentritic cells. Blood. 99:1825-

1832. PMID: 11861301

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11. Ordemann R, Hutchinson R, Friedman J, Burakoff SJ, Reddy P,

Duffner U, Braun TM, Liu C, Teshima T, Ferrara J. (2002)

Enhanced allostimulatory activity of host antigen-presenting cells

in old mice intensifies acute graft-versus-host disease Journal of

Clinical Investigation. 109:1249-56. PMID: 11994414

12. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Reed A, Hemming A,

Howard R, Van Der Werf W, Lauwers G, Liu C, Crawford JM,

Davis GL, Nelson DR. Combination of interferon alfa-2b and

ribavirin in liver transplant recipients with histological recurrent

hepatitis C. Liver Transplantation 2002 Nov;8(11):1000-1006.

PMID: 12424712

13. Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke KR &

Ferrara JM (2002) Acute graft-versus-host disease does not require

alloantigen expression on host epitheLium. Nature Medicine

8:575-581. (Cover article). PMID: 12042807

14. Hildebrandt, G.C., Duffner, U.A., Olkiewicz, K.M., Willmarth,

N.E., Corrion, L.A., Clouthier, S., Williams, D.L., Reddy, P.R.,

Moore, B.B., Liu, C., and K.R. Cooke. (2003). A Critical Role for

CCR2 in the development of idiopathic pneumonia syndrome after

allogeneic bone marrow transplantation. Blood, 2004 103:2417-

2426. PMID: 14615370

15. Duffner, U., Lu, B., Teshima, T., Williams, D.L., Hildebrandt, G.,

Reddy, P., Ordemann, R., Lowler, K., Liu, C., Cooke, K.R., and

Ferrara J.L.M. (2003) Role of CXCR3-induced donor T-cell

migration in acute GVHD. Experimental Hematolology. (10):897-

902. PMID: 14550805

16. Nelson DR, Tu Z, Soldevila-Pico C, Abdelmalek M, Zhu H, Xu

YL, Liu, C, Davis GL (2003) Long-term interleukin 10 therapy in

chronic hepatitis C patients has a proviral and anti-inflammatory

effect. Hepatology, 38(4):859-68. PMID: 14512873

17. Clouthier S, Cooke KR, Teshima T, Lowler KP, Liu C, Connolly

K, Ferrara JL (2003) Repifermin (Keratinocyte Growth Factor-2),

delays onset of graft-versus-host disease while preserving a graft-

versus-leukemia effect. Biology of Bone marrow, Blood and

Transplantation. (9):592-603. PMID: 14506661

18. Reddy P, Teshima T, Hildebrandt G, Williams DL, Liu C, Cooke

KR, Ferrara JL. (2003) Pretreatment of donors with interleukin-18

attenuates acute graft-versus-host disease via STAT6 and preserves

graft-versus-leukemia effects. Blood 101(7):2877-85. PMID:

12433681

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19. Teshima T, Reddy P, Liu C, Williams D, Cooke KR, Ferrara JL.

(2003) Impaired thymic negative selection causes autoimmune

graft-versus-host disease. Blood 102(2):429-35. PMID: 12663438

20. Ichiba T, Teshima T, Kuick R, Misek DE, Liu C, Takada Y,

Maeda Y, Reddy P, Williams DL, Hanash S, Ferrara JL. (2003)

Early changes in gene expression profiles of hepatic GVHD

uncovered by oligonucleotid microarrays. Blood 102(2):763-71.

PMID: 12663442

21. Petrovic, A; Alpdogan, O; Willis, LM; Eng, JM; Greenberg, AS;

Kappel, BJ; Liu, C; Murphy, G; Heller, G and van den Brink, MR

(2004) LPAM ( / integrin) is an important homing integrin on

alloreactive T cells in the development of intestinal Graft-Versus-

Host Disease. Blood.103: 1542-1547. PMID: 14563643

22. Zhu, HZ; Liu, C. (2003) Interleukin 1 inhibits hepatitis C viral

RNA replication by activation of extracellular regulated kinase

pathway. Journal of Virology. 77:5493-5498. PMID: PMC153991

23. Zhu, H.Z; Zhao, HS; Collins, CD; Eckenrode, SE; Run, Q;

McIndoe, RA; Crawford, JM; Nelson, DR; She, JX; Liu, C. Gene

expression associated with IFN alpha antiviral activity in an HCV

replicon cell line. (2003) Hepatology, 37:1180-1188.

EDITORIAL: on page 975. PMID: 12717400

24. Hassanein A, Glanz S, Kessler H, Eskin T, Liu C (2003) Beta

catenin is aberrantly expressed in tumors expression shadow cells:

pilomatricoma, craniopharyngioma, and calcifying odontogenic

tumor. American J Journal of Clinical Pathology. 120(5):732-6.

PMID: 14608900

25. Liu, C; Zhu, HZ; Xu, YL; Nelson, DR. (2003) CD8+ T cell

interaction with HCV replicon cells: evidence for both cytokine-

and cell-mediated antiviral activity. Hepatology, 37:1335-1342.

PMID: 12774012

26. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Cabrera R, Shuster JJ,

Theriaque D, Reed AI, Hemming AW, Liu C, Crawford JM, and

Nelson DR.(2004) One-year Protocol Liver Biopsy Can Stratify

Fibrosis Progression In Liver Transplant Recipients With

Recurrent Hepatitis C Infection. Liver Transplantation. 40:1062-

71. PMID: 15376304

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27. Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D,

Boyd A, Kupper TS, Burakoff SJ. (2004) Increasing T-cell age

reduces effector activity but preserves proliferative capacity in a

murine allogeneic major histocompatibility complex-mismatched

bone marrow transplant model. Biology of Blood Marrow

Transplantation.10:448-60. PMID: 15205666

28. Hildebrandt, GC; Olkiewicz, KM; Chang, Y; Liu, C; Cooke, KR

(2004) Donor-dreived TNF regulates pulmonary chemokine

expression and the development of idiopathic pneumonia

syndrome after allogenic bone marraow transplantation. Blood,

104:586-93. PMID: 15069018

29. Persad, R; Liu, C; Wu, TT; Houlihan, PS; Hamilton, SR; Diehl,

AM, Rashid, A (2004) Overexpression of caspase 3 in

hepatocellular carcinoma. Modern Pathology, 17(8) 1026. PMID:

15098015

30. Abdelmalek MF, Firpi RJ, Soldevila-Pico C, Reed AI, Hemming

AW, Liu C, Crawford JM, Davis GL, Nelson DR (2004) Sustained

viral response to interferon and ribavirin in liver transplant

recipients with recurrent hepatitis C. Liver Transplantation.

10(2):199-207. PMID: 14762857

31. Hildebrandt GC, Corrion, LA, Olkiewicz, KM, Lowler, K, Moore,

BB, Kuziel, WA, Liu, C and Cooke, KR. (2004) Blockade of

CXCR3 receptor:ligand interactions reduces leukocyte recruitment

to the lung and the severity of experimental idiopathic pneumonia

syndrome Journal of Immunology, 173:2050-9. PMID: 15265940

32. Duffner, UA; Maeda, Y; Cooke, KR; Reddy, P; Ordemann, R; Liu,

C; Ferrara, JL. (2004) Host dendritic cells alone are sufficient to

initiate acute graft-versus-host-disease. Journal of Immunology.

172:7393-7398 PMID: 15178116

33. Min CK, Maeda Y, Lowler K, Liu, C, Clouthier S, Lofthus D,

Weisiger E, Ferrara JL, Reddy P. (2004) Paradoxical effects of

interleukin-18 on the severity of acute graft-versus-host disease

mediated by CD4+ and CD8+ T cell subsets after experimental

allogeneic bone marrow transplantation. Blood, 104:3393-3399.

PMID: 15280194

34. Camp ER, Hochwald SN, Liu C. (2004) FAP with concurrent

duodenal adenomatous polyposis and carcinoid tumor. Journal of

Surgical Oncology. 87(4):187-90. PMID: 15334634

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35. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, Nelson DR.

(2004) An immunomodulatory role for CD4(+)CD25(+) regulatory

T lymphocytes in hepatitis C virus infection. Hepatology, 40:

1062-71. PMID: 15486925

36. Reddy P; Maeda, Y; Hotary, K; Liu C; Reznikove, LL; Dinarello,

CA, Ferrara, JM (2004) Histone deacetylase inhibitor

suberoylanilide hydroxamic acid reduces acute graft-versus-host

disease and preserves graft-versus leukemia effect. Proceeding of

National Academy of Science. U.S.A, 101:3921-3926. PMCID:

PMC374345

37. Li, M; Liu, C. (2004) Cytokeratin 20 confirms Merkel cell

metastasis to stomach. Applied Immunohistochemistry and

Molecular Morphology. 12:346-349. PMID: 15536335

38. Gerbitz A, Nickoloff BJ, Olkiewicz K, Willmarth NE, Hildebrandt

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199. Das DK, Naidoo MK, Ilboudo A, DuBois P, Durojaiye V, Liu C,

Ogunwobi OO. (2015) Isolation and Propagation of Circulating

Tumor Cells from a Mouse Cancer Model. J Vis Exp. 2015 Oct

9;(104). PMID: 26484891

of 53

200. Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH,

Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM,

Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML,

O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo

T, Dow LE, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R,

van den Brink MR, Hanash AM. (2015) Interleukin-22 promotes

intestinal-stem-cell-mediated epithelial regeneration. Nature. Dec

24;528(7583):560-4. Epub 2015 Dec 9. PMID: 26649819

201. Nguyen HD, Chatterjee S, Haarberg KM, Wu Y, Bastian D,

Heinrichs J, Fu J, Daenthanasanmak A, Schutt S, Shrestha S, Liu

C, Wang H, Chi H, Mehrotra S, Yu XZ. (2016) Metabolic

reprogramming of alloantigen-activated T cells after hematopoietic

cell transplantation. J Clin Invest. 2016 Apr 1;126(4):1337-52

202. Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu C, Jin J,

Anasetti C, Yu XZ. (2016) T-bet Promotes Acute Graft-versus-

Host Disease by Regulating Recipient Hematopoietic Cells in

Mice. J Immunol. 2016 Apr 1;196(7):3168-79. Epub 2016 Feb 22

203. Zhou K, Xia M, Tang B, Yang D, Liu N, Tang D, Xie H, Wang X,

Zhu H, Liu C, Zuo C. (2016) Isolation and comparison of

mesenchymal stem cell‑like cells derived from human gastric

cancer tissues and corresponding ovarian metastases. (2015) Mol

Med Rep. Feb;13(2):1788-94. Epub 2015 Dec 30. PMID:

26718033

204. Pham K, Delitto D, Knowlton A, Hartlage ER, Madhavan R,

Gonzalo DH, Thomas R, Behrns KE, George T, Hughes S, Wallet

S, Trevino J, Liu C (2016) Isolation of Pancreatic Cancer Cells

from a Patient-Derived Xenograft Model, Allows for Practical

Expansion and Preserved Heterogeneity in Culture. Am. J.

Pathology. Jun;186(6):1537-46. Epub 2016 Apr 18. PMID:

27102771

205. Li W, Liu L, Gomez A, Zhang J, Ramadan A, Zhang Q, Choi SW,

Zhang P, Greenson JK, Liu C, Jiang D, Virts E, Kelich SL, Chu

HW, Flynn R, Blazar BR, Hanenberg H, Hanash S, Paczesny S.

(2016) Proteomics analysis reveals a Th17-prone cell population in

presymptomatic graft-versus-host disease. JCI Insight. 2016 May

5;1(6). pii: e86660.

https://www.ncbi.nlm.nih.gov/pubmed/27195312

https://www.ncbi.nlm.nih.gov/pubmed/27195312

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206. Delitto D, Black BS, Cunningham HB, Sliesoraitis S, Lu X, Liu C,

Sarosi GA, Thomas RM, Trevino JG, Hughes SJ, George TJ Jr,

Behrns KE. Standardization of surgical care in a high-volume

center improves survival in resected pancreatic head cancer. Am J

Surg. 2016 Aug;212(2):195-201.e1. Epub 2016 May 10. PMID:

27260793; PMCID: PMC4969126.

207. Heinrichs J, Li J, Nguyen H, Wu Y, Bastian D, Daethanasanmak

A, Sofi MH, Schutt S, Liu C, Jin J, Betts B, Anasetti C, Yu XZ.

(2016) CD8(+) Tregs promote GVHD prevention and overcome

the impaired GVL effect mediated by CD4(+) Tregs in mice.

Oncoimmunology. 2016 Mar 28;5(6):e1146842.

208. Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai

JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR,

Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M,

Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA,

Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss

EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink

MR, Jenq RR. Increased GVHD-related mortality with broad-

spectrum antibiotic use after allogeneic hematopoietic stem cell

transplantation in human patients and mice. Sci. Transl Med. 2016

May 18;8(339)

209. Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey

VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Lazrak A,

Marinis JM, Beal A, Harris PA, Bertin J, Liu C, Ding Y, van den

Brink MRM, Cadwell K. (2017) Autophagy protein ATG16L1

prevents necroptosis in the intestinal epithelium. J Exp Med. 2017

Dec 4;214(12):3687-3705. PMID: 29089374

210. Nieves EC, Toubai T, Peltier DC, Oravecz-Wilson K, Liu C,

Tamaki H, Sun Y, Reddy P. STAT3 Expression in Host Myeloid

Cells Controls Graft-versus-Host Disease Severity. Biol Blood

Marrow Transplant. 2017 Jul 8. pii: S1083-8791(17)30549-9.

[Epub ahead of print] PubMed PMID: 28694183.

211. Fischer JC, Bscheider M, Eisenkolb G, Lin CC, Wintges A, Otten

V, Lindemans CA, Heidegger S, Rudelius M, Monette S,

Porosnicu Rodriguez KA, Calafiore M, Liebermann S, Liu C,

Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y,

Docampo M, Velardi E, Jenq RR, Hanash AM, Dudakov JA, Haas

T, van den Brink MRM, Poeck H. RIG-I/MAVS and STING

signaling promote gut integrity during irradiation- and immune-

mediated tissue injury. Sci Transl Med. 2017 Apr 19;9(386). pii:

eaag2513. PubMed PMID: 28424327.

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212. Hlady RA, Zhou D, Puszyk W, Roberts LR, Liu C, Robertson

KD. (2017) Initiation of aberrant DNA methylation patterns and

heterogeneity in precancerous lesions of human hepatocellular

cancer. Epigenetics. 2017 Mar 4;12(3):215-225. PMID: 28059585;

PMCID: 5406211.

213. Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER,

Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM,

George TJ Jr, Brusko TM, Mathews CE, Liu C, Trevino JG,

Hughes SJ, Wallet SM.(2017) Human Pancreatic Cancer Cells

Induce a MyD88-Dependent Stromal Response to Promote a

Tumor-Tolerant Immune Microenvironment. Cancer Res. 2017

Feb 1;77(3):672-683.. Epub 2016 Nov 18. PMID: 27864347;

PMCID: PMC5290036.

214. Ramadan A, Griesenauer B, Adom D, Kapur R, Hanenberg H, Liu

C, Kaplan MH, Paczesny S. Specifically differentiated T cell

subset promotes tumor immunity over fatal immunity. (2017) J

Exp Med. 2017 Dec 4;214(12):3577-3596. doi:

10.1084/jem.20170041. Epub 2017 Oct 16.PMID: 29038366

215. Wu Q, Pi L, Le Trinh T, Zuo C, Xia M, Jiao Y, Hou Z, Jo S,

Puszyk W, Pham K, Nelson DR, Robertson K, Ostrov D,

Rameshwar P, Xia CQ, Liu C (2017). A Novel Vaccine Targeting

Glypican-3 as a Treatment for Hepatocellular Carcinoma. Mol

Ther. 2017 Oct 4;25(10):2299-2308. Epub 2017 Aug 10. PMID:

28865999

216. Toubai T, Rossi C, Oravecz-Wilson K, Zajac C, Liu C, Braun T,

Fujiwara H, Wu J, Sun Y, Brabbs S, Tamaki H, Magenau J, Zheng

P, Liu Y, Reddy P. Siglec-G represses DAMP-mediated effects on

T cells. JCI Insight. 2017 Jul 20;2(14). pii: 92293. [Epub ahead of

print] PMID: 28724800

217. Ghosh A, Smith M, James SE, Davila ML, Velardi E,

Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER,

Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young

LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC,

Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR.

Donor CD19 CAR T cells exert potent graft-versus-lymphoma

activity with diminished graft-versus-host activity. Nat Med. 2017

Feb;23(2):242-249. Epub 2017 Jan 9. PMID: 28067900

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218. Zhou D, Hlady RA, Schafer MJ, White TA, Liu C, Choi JH,

Miller JD, Roberts LR, LeBrasseur NK, Robertson KD. High fat

diet and exercise lead to a disrupted and pathogenic DNA

methylome in mouse liver. Epigenetics. 2017 Jan 2;12(1):55-69.

Epub 2016 Nov 18. PMID: 27858497

219. Wu Q, Jorgensen M, Song J, Zhou J, Liu C, Pi L. Members of the

Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic

Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma.

Gastroenterol Res Pract. 2016;2016:2313850. Epub 2016 Oct 18.

PMID: 27829832

220. Khodayari N, Wang RL, Marek G, Krotova K, Kirst M, Liu C,

Rouhani F, Brantly M. SVIP regulates Z variant alpha-1

antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78.

PLoS One. 2017 Mar 16;12(3):e0172983. eCollection 2017.

PubMed PMID: 28301499; PMCID: PMC5354272.

221. Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH,

Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR,

Hu CC, Yu XZ. (2018) Inhibition of the IRE-1α/XBP-1 pathway

prevents chronic GVHD and preserves the GVL effect in mice.

Blood Adv. 2018 Feb 27;2(4):414-427. PMID: 29483082

222. Betts BC, Bastian D, Iamsawat S, Nguyen H, Heinrichs JL, Wu Y,

Daenthanasanmak A, Veerapathran A, O'Mahony A, Walton K,

Reff J, Horna P, Sagatys EM, Lee MC, Singer J, Chang YJ, Liu C,

Pidala J, Anasetti C, Yu XZ.(2018) Targeting JAK2 reduces

GVHD and xenograft rejection through regulation of T cell

differentiation. Proc Natl Acad Sci U S A. 2018 Feb

13;115(7):1582-1587. PMID:29382747.

223. Iamsawat S, Daenthanasanmak A, Voss JH, Nguyen H, Bastian D,

Liu C, Yu XZ. Stabilization of Foxp3 by Targeting JAK2

Enhances Efficacy of CD8 Induced Regulatory T Cells in the

Prevention of Graft-versus-Host Disease. J Immunol. 2018 Sep 21.

[Epub ahead of print] PMID: 30242073

224. Fujiwara H, Docampo MD, Riwes M, Peltier D, Toubai T, Henig I,

Wu SJ, Kim S, Taylor A, Brabbs S, Liu C, Zajac C, Oravecz-

Wilson K, Sun Y, Núñez G, Levine JE, van den Brink MRM,

Ferrara JLM, Reddy P. Microbial metabolite sensor GPR43

controls severity of experimental GVHD. Nat Commun. 2018 Sep

10;9(1):3674.

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225. Clark VC, Marek G, Liu C, Collinsworth A, Shuster J, Kurtz T,

Nolte J, Brantly M. Clinical and histologic features of adults with

alpha-1 antitrypsin deficiency in a non-cirrhotic cohort.

Hepatology. 2018 Aug 21. [Epub ahead of print] PMID: 30138687

226. Hlady RA, Sathyanarayan A, Thompson JJ, Zhou D, Wu Q, Pham

K, Lee JH, Liu C, Robertson KD. Integrating the Epigenome to

Identify Novel Drivers of Hepatocellular Carcinoma. Hepatology.

2018 Aug 22. [Epub ahead of print] PMID: 30136421

227. Paratala BS, Chung JH, Williams CB, Yilmazel B, Petrosky W,

Williams K, Schrock AB, Gay LM, Lee E, Dolfi SC, Pham K, Lin

S, Yao M, Kulkarni A, DiClemente F, Liu C, Rodriguez-

Rodriguez L, Ganesan S, Ross JS, Ali SM, Leyland-Jones B,

Hirshfield KM. RET rearrangements are actionable alterations in

breast cancer. Nat Commun. 2018 Nov 16;9(1):4821. PMID:

30446652

228. Toubai T, Tamaki H, Peltier DC, Rossi C, Oravecz-Wilson K, Liu

C, Zajac C, Wu J, Sun Y, Fujiwara H, Henig I, Kim S, Lombard

DB, Reddy P. Mitochondrial Deacetylase SIRT3 Plays an

Important Role in Donor T Cell Responses after Experimental

Allogeneic Hematopoietic Transplantation. J Immunol. 2018 Dec

1;201(11):3443-3455. Epub 2018 Nov 2. PMID: 30389773

229. Tsai JJ, Velardi E, Shono Y, Argyropoulos KV, Holland AM,

Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young

LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF,

Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM.

Nrf2 regulates CD4+ T cell-induced acute graft-versus-host

disease in mice.Blood. 2018 Dec 27;132(26):2763-2774.. Epub

2018 Oct 31. PMID: 30381375

230. Iamsawat S, Daenthanasanmak A, Voss JH, Nguyen H, Bastian D,

Liu C, Yu XZ. Stabilization of Foxp3 by Targeting JAK2

Enhances Efficacy of CD8 Induced Regulatory T Cells in the

Prevention of Graft-versus-Host Disease. J Immunol. 2018 Nov

1;201(9):2812-2823. Epub 2018 Sep 21. PMID: 30242073

231. Daenthanasanmak A, Iamsawat S, Chakraborty P, Nguyen HD,

Bastian D, Liu C, Mehrotra S, Yu XZ. Targeting Sirt-1 controls

GVHD by inhibiting T-cell allo-response and promoting Treg

stability in mice. Blood. 2019 Jan 17;133(3):266-279. PMID:

30514750

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232. Zhang X, Pham K, Li D, Schutte RJ, Brantly M, Liu C, Ostrov

DA. Targeting the site encoded by SERPINA1*E342K for treating

alpha-1 antitrypsin deficiency-associated liver diseases. FEBS Lett.

2019 May 22. [Epub ahead of print] PMID: 31116417

233. Sivaram N, McLaughlin PA, Han HV, Petrenko O, Jiang YP,

Ballou LM, Pham K, Liu C, van der Velden AW, Lin RZ. umor-

intrinsic PIK3CA represses tumor immunogenecity in a model of

pancreatic cancer. J Clin Invest. 2019 May 21;130. pii: 123540.

PMID: 31112530

234. Sofi MH, Wu Y, Schutt SD, Dai M, Daenthanasanmak A,

Heinrichs Voss J, Nguyen H, Bastian D, Iamsawat S, Selvam SP,

Liu C, Maulik N, Ogretmen B, Jin J, Mehrotra S, Yu XZ.

Thioredoxin-1 confines T cell alloresponse and pathogenicity in

graft-versus-host disease. J Clin Invest. 2019 May 2;130:2760-

2774.

235. Toubai T, Fujiwara H, Rossi C, Riwes M, Tamaki H, Zajac C, Liu

C, Mathew AV, Byun J, Oravecz-Wilson K, Matsuda I, Sun Y,

Peltier D, Wu J, Chen J, Seregin S, Henig I, Kim S, Brabbs S,

Pennathur S, Chen G, Reddy P. Host NLRP6 exacerbates graft-

versus-host disease independent of gut microbial composition. Nat

Microbiol. 2019 May;4(5):800-81. Epub 2019 Mar 11. PMID:

30858572

236. Wang L, Marek GW 3rd, Hlady RA, Wagner RT, Zhao X, Clark

VC, Fan AX, Liu C, Brantly M, Robertson KD. Alpha-1

Antitrypsin Deficiency Liver Disease, Mutational Homogeneity

Modulated by Epigenetic Heterogeneity With Links to Obesity.

Hepatology. 2019 Jul;70(1):51-66. Epub 2019 Mar 20.

B. Books, Monographs and Chapters

1. Wu TT, Condreay LD, Liu C, Mason WS and Jibert JR (1991)

Hepadnavirus DNA synthesis. In: 1990 international symposium on

viral hepatitis and liver disease ed. Hollinger, B; Margolis H; William

and Wilkins. 114-121.

2. Mason WS, Summers J, Liu C, Condreay LD, Wu TT (1991) Chronic

hepadnavirus infection. In: international symposium on hepatitis delta

virus, ed. Gerin, J; Purcell; Rizetto, M Wiley-Liss, Inc. 235-242.

3. Liu C; Crawford JM. (2003) Liver anatomy. In: Madara ed.

“Encyclopedia of Gastroenterology.” pp 510-515.

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4. Liu C; Crawford JM. (2003) Liver biopsy. In: Madara ed.

“Encyclopedia of Gastroenterology.” pp. 516-522.

5. Liu C; Crawford JM. (2004) Chapter 17, Pathology of gastrointestinal

tract. In “Robbins Pathologic Basis of Disease”. 7 th edn. pp. 410-

474.

6. Liu C; Crawford JM. (2004) Graft-versus-Host Disease of the Liver.

In: Ferrara ed. “Graft-vs-Host Disease.” 3 rd edn. Marcel Dekker, New

Yrok. pp: 257-278.

7. Liu C; Crawford JM (2005) Chapter 17 and 18, in “Robbins and

Cotran Pathologic Basis of Disease.” Pocket book. pp. 516-522.

8. Liu C (2006) Hepatitis C Virology and Experimental Models. “Clinics

in Liver Disease”. 10:773-791.

9. Liu C (2009) Primary Hepatocyte Culture in HCV Research.

"Hepatitis C Protocols". Methods Mol Biol. 2009;510:373-82.

10. Liu C, Crawford JM (2009) Chapter 18, Liver Pathology, in Robbins

and Cotran Pathologic Basis of Disease, 8 th ed.

11. Liu C, Crawford JM. (2009) Pathological staging of biliary tract

cancers. In Biliary Tract and Gallbladder Cancers. Pp. 77-84 Ed.

Thomas and Fuller, Demos Medical, New York.

12. Kim Y, Liu C, Tan WH, (2009) Aptamers generated by cell-based

SELEX for biomarker discovery. Biomark Med. 2009 Apr;3(2):193-

202.

13. Ogunwobi O, Liu C. (2011) Therapeutic markers for liver cancer

metastasis. Critical Reviews in Oncology/Hematology. 2012

Sep;83(3):319-28, 2011 Dec 16. [Epub ahead of print].

14. Tan W, Wang H, Chen Y, Zhang X, Zhu H, Yang C, Yang R, Liu C.

(2011) Molecular aptamers for drug delivery. Trends Biotechnology.

2011 Dec;29(12):634-40.

15. Liu C (2012) Guardian and selective killer: the versatile functions of

TLR3 in hepatocellular carcinoma. J National Cancer Institute. 2012

Dec 5;104(23):1780-2

16. Fyfe B, Zaldana F, Liu C. The Pathology of Acute Liver Failure. Clin

Liver Dis. 2018 May;22(2):257-268. doi: 10.1016/j.cld.2018.01.003.

PMID: 29605065

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17. Liu C (2018) Precision Pathology of Liver Cancer, Editor

C. Patents Held

1. Human Liver Cancer Cell Line, US patent 8017391, issued September

2011

2. Compounds for alpha-1 antitrypsin deficiency treatment, US patent

6403646, issued May 2013

3. New polypeptide for alpha-1 antitrypsin deficiency, US patent

application, US12/522,958

4. Epigenetic markers for liver cancer, US patent application, filed in

January, 2011

5. Nanozyme as a new therapeutic agent for infection and cancer, US

patent application, filed in March 2011

D. Other Articles (Reviews, Editorials, etc.) In Journals; Chapters; Books; other

Professional Communications

See Section B

Abstracts (Representative)

1. Jose Varillas, Weian Sheng, Kangfu Chen, Thomas George, Liu C,

Hugh Fan. Capture of Circulating Tumor Cells (CTCs) in

Microfluidic Devices for Patient Treatment Monitoring. BMES

2015 Annual Meeting, scheduled for October 7-10, 2015

2. Thu Le Trinh, Guizhi Zhu, Xilin Xiao, Xiaokui Zhang, Kwame

Sefah, Weihong Tan, and Liu C. AS1411-Doxorubicin adduct for

targeted liver cancer therapy. 2013 AACR-NCI-EORTC Molecular

Targets and Cancer Therapeutics Conference, October 19-23,

Boston MA.

3. Olorunseun O. Ogunwobi, Thu L. Trinh, and Liu C. Human

glypican-3 promotes hepatocellular carcinoma progression via

induction of epithelial-mesenchymal transition. AACR 103rd

Annual Meeting 2012-- Mar 31-Apr 4, 2012; Chicago, IL

4. Thu Le Trinh, K. Safah, W. Tan, Liu C. AS1411 as a Potential

Anti-Cancer Reagent for Treatment of Hepatocellular Carcinoma.

24th EORTC-NCI-AACR symposium on ‘Molecular targets and

cancer therapeutics’– 6-9 November 2012, Dublin, Ireland.

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5. Thu Le Trinh and Liu C. Glypican-3 as a potential therapeutic

target for hepatocellular carcinoma immunotherapy. Experimental

biology 2012– April 21-25, 2012; San Diego, CA

6. Jeung J, Patel R, Wakefield D, Liu C Characterization of HER2

Expression in Primary Gastroesophageal adenocarcinoma. USCAP

100th Annual Meeting, Feb. 2011, Modern Pathology, 24:153A.

7. Liu J, Zhu HZ, Liu HY, Nelson, DR, Liu C (2010) TRAIL agonist

resistance is associated with death receptor mutations. Digestive

Disease Week, May, 2010. (Oral Presentation)

8. Ogunwobi OO, Liu C. Hepatocyte growth factor upregulation and

signaling is associated with carcinogenesis and mesenchymal

characteristics in hepatocellular carcinoma. American Association

for Cancer Research Annual Meeting, Orlando, Florida, USA,

April 2011.

9. Ogunwobi OO, Zhang L, Liu C. Multiple growth factors induce

epithelial-mesenchymal transition in novel liver cancer cell lines.

American Association for Cancer Research Special Conference on

EMT and Cancer Progression and Treatment, Arlington, Virginia,

USA, February 2010.

10. Gilliland K, Dong, HJ, Hochwald, S, Liu C The role of k-ras

mutations in pancreatic neuroendocrine tumors. USCAP Annual

Meeting, March, 2010. Modern Pathology, 23:355A.

11. Liu C, Cardona D, Dong J K-ras mutations in hepatocellular

carcinoma. USCAP Annual Meeting, March, 2010, Modern

Pathology, 23:363A.

12. Zhao XX, Zhu HZ, Zhang XK, Liu J, Nelson DR, and Liu C

Cycloheximide sensitizes TRAIL-agonist-induced apoptosis in

liver cancer cells AACR Cell death mechanisms and cancer

therapy Feb, San Diego, CA, 2010 Culture and immortalization of

hepatitis C viral positive human hepatocytes. Poster, AASLD,

2003. Hepatology, 34: 462A

Reports

N/A

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PRESENTIONS:

A. Scientific (Basic Science):

2001 University of Michigan, Liver pathology in graft-versus-host

disease.

2003 Institute for Medicinal Biotechnology, Chinese Academy of

Medical Sciences. Interferon signaling in hepatitis C viral

infection.

2003 Institute for Infectious Diseases, Beijing, China. Functional

genomics in hepatitis C viral infection.

2004 Keynote speaker, Shandong University, China, Hepatitis C

diagnosis and therapy.

2005 Harvard Medical School, Innate and adaptive immunity in HCV

infection.

2005 Invited speaker, Alpha-1 Foundation International Scientific

Conference, Small molecules for AAT deficient therapy.

2007 Invited speaker, Chinese Academy of Medical Sciences, Innate

immunity in HCV.

2008 Invited speaker, China Medical University, Novel therapy for liver

cancer.

2008 Falk Symposium, Mainz, Germany, Trail agonists for liver cancer

therapy

2008 Invited speaker, Inner Mongolia Medical College. Liver disease

updated therapies.

2008 College of Veterinary Medicine, University of Florida. Innate

Immunity

2008 Harvard Medical School and Brigham and Women's Hospital,

TRAIL pathway in hepatitis C viral infection and liver cancer.

2008 Invited speaker, Moffitt Cancer Center. Immunotherapy for HCV

and liver cancer.

2008 Keynote speaker, Florida State University, Innate immunity in

hepatitis C infection

2008 Duke University Medical Center, "Apoptosis in HCV and Liver

cancer".

of 53

2009 Invitrogen Inc. " Liver cell line and mouse model in liver disease

research.

2009 Keynote speaker and scientific session chair, 2nd World cancer

congress

2009 Invited speaker, Beijing University, "Hepatitis C animal models".

2009 Invited speaker, Hunan University "Liver cancer therapy, current

progress".

2009 Invited speaker, Chinese Academy of Sciences, "Aptamer in

translational medicine".

2010 Invited speaker, Penn State School of Medicine, "TRAIL-agonists

in liver cancer therapy".

2010 Invited speaker, Drexel University, Institute of Biotechnology.

Apoptosis and liver cancer therapy.

2011 Invited speaker, Medical College of Georgia. "Developing novel

therapeutic strategies for liver cancer."

2012 Invited speaker, University of Kentucky. "Immunotherapy for

Liver Cancer".

2012 Invited speaker, 5th International Symposium on Bioanalysis,

Biomedical Engineering and Nanotechnology. "Nanotechnology

application in cancer therapy".

2013 Invited speaker, 14th SCBA International symposium

“Epigenetic and genetic factors in hepatitis C infection and

treatment response”

2014 Invited speaker, Duke University Medical Center

“Liver Cancer in the Era of Personalized Medicine”

2014 Invited Speaker, Rutgers University New Jersey Medical School

“Immunotherapy for Liver Cancer”

2014 Invited Speaker, Dartmouth Medical School

“Therapeutic Strategies for Liver Cancer Therapy”

2016 Invited Speaker, New York Medical College

“Opportunities and Challenges in Cancer Immunotherapy”

of 53

2017 Alpha Omega Alpha Keynote Speaker

“The Discovery of Hepatitis Viruses and the Current Challenges”

2018 Grand Rounds Speaker, McGill University, Canada

“Cancer Immunotherapy”

2019 Grand Rounds speaker, Geisinger Health

“Epigenetics in liver cancer”

B. Professional (Clinical): 2003 University of Florida, Cancer Center, Grand Round.

Pathogenesis of Liver Cancer.

2004 University of Florida, Division of Critical Care & Pulmonary

Medicine. Hepatic injury in alpha-1 antitrypsin deficiency.

2005 Grand rounds, University of Florida Cancer Center.

Liver Cancer Diagnosis and Therapy.

2007 Invited speaker, US-Canadian Academy of Pathology Annual

Meeting Hepatocellular Lesions: Diagnosis and differential

diagnosis.

2009 Invited speaker, Hunan University "Liver cancer therapy, current

progress".

2010 Invited speaker, Chinese pathology association annual conference,

Chongqing, China, Pathology of Liver Lesions

2011 Invited speaker, University of Louisville.

"Hepatocellular carcinoma in the era of personalized medicine."

2014 Grand Rounds, Department of Pathology, Tulane University

“Immunotherapy for Liver Cancer”.

2014 Grand Rounds, University of Florida Cancer Center

“Mechanisms of Cancer Metastasis”.

2014 Grand Rounds, Case Western Reserve University

“Liver Cancer, A Translational Approach”

2014 Grand Rounds, The Methodist Hospital, Houston, Texas

“Personalized Medicine for Liver Cancer Therapy”.

of 53

2014 Invited Speaker, North America Neuroendocrine Tumor Society

meeting, Orlando

“Pathology of GI and Liver neuroendocrine tumor”.

2014 Grand Rounds, Tulane University

“Liver cancer immunotherapy”

2018 Grand Rounds Speaker, McGill University, Canada

“Cancer Immunotherapy”

2019 Grand Rounds speaker, Geisinger Health

“Epigenetics in liver cancer”

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