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Richard L. Hughes, MD - of 21

CURRICULUM VITAE

RICHARD L. HUGHES, M.D.

Professor of Neurology

12401 East Seventeenth Avenue, Mail Stop L950

Aurora, CO 80045

720.848.8522

720.848.0194 (Fax)

303.399.1261 (Home)

303.880.0908 (Cell)

[email protected]

BIOGRAPHY:

Birth Date: June 5, 1955

Birthplace: Rumford, Maine

EDUCATION AND EXPERIENCE:

1972-1973 New Mexico Highlands University, Las Vegas, New Mexico

1973-1976 B.A. Chemistry University of New Mexico, Albuquerque, New Mexico

1978-1982 M.D. University of New Mexico School of Medicine, Albuquerque, New Mexico

1982-1983 Intern, Medicine and Psychiatry, University of New Mexico, Albuquerque, New Mexico

1983-1986 Resident in Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania

1986-1987 Clinical Fellow in Cerebrovascular Disease, University of Colorado, Denver, Colorado

ACADEMIC APPOINTMENTS:

1987-1991 Ochsner Clinic, Tulane University Medical School Rehabilitation Unit

New Orleans, Louisiana, Staff Neurologist-General Partner Department of Neurology,

Clinical Assistant Professor of Neurology

1991-2016 Denver Health Medical Center, University of Colorado School of Medicine

Denver, Colorado, Division of Neurology (Chief 1995), Professor of Neurology (2008)

2016-present University of Colorado, Anschutz Medical Campus, Professor of Neurology

HONORS, SPECIAL RECOGNITIONS AND AWARDS:

1995 Outstanding Teacher of the Year, University of Colorado, Department of Neurology

Resident Class of 1995

1997-1998 Excellence in Teaching Award, University of Colorado, Department of Neurology

1998-1999 Excellence in Teaching Award, University of Colorado, Department of Neurology


1999-2000 Excellence in Teaching Award, University of Colorado, Department of Psychiatry

2000 American Heart Association, Robert Ginsberg Medical Volunteer of the Year

2001 7th Annual Outstanding Clinician Award, Denver Health Medical Center

2003 Outstanding Teacher of the Year, University of Colorado, Medical School Class of 2003

2003 “Mr. Smooth Award,” University of Colorado, 2003 Residency Class

2003 American Heart Association, Advocate of the year – Colorado

2003-2006 Best Doctors in America®

2007 Nominee, University of Colorado Teaching Excellence

2008 Nominee, University of Colorado Teaching Excellence

2009-2016 Best Doctors in America®

2017 Resident Teaching Award, University of Colorado

PROFESSIONAL ORGANIZATIONS:

American Academy of Neurology Fellow

American Heart Association

American Medical Association Fellow

Colorado Acute Stroke Network (Co-Founder)

Colorado Society of Clinical Neurologists

North American Neuro-Ophthalmology Society

Stroke Council

MAJOR COMMITTEE AND SERVICE RESPONSIBILITIES:

1993-1995 President, Colorado Society of Clinical Neurologists

1995-1996 Secretary - Treasurer, Denver General Hospital

1996-2002 Rocky Mountain Stroke Association (Board)

1997-present American Heart Association, Denver Board

1998-2002 Chairman, AHA Desert Mountain Affiliate Stroke Advisory Committee

1999-2002 Co-Chair, Denver Operation Stroke, American Stoke Association


2000-2003 University of Colorado School of Medicine Faculty Senate

2000-2003 American Heart Association Desert-Mountain Affiliate Board

2001-2004 American Stroke Association Advisory Board

2002-present Colorado Department of Public Health and Environment Stroke Advisory Committee

2002-2006 American Heart Association Pacific Mountain Affiliate Stroke Committee

2002-2011 ASA/JCAHO Primary Stroke Center Certification Committee

2005-2011 ASA/JCAHO Comprehensive Stroke Center Certification Committee

2006-2008 AHA PMA Strategic Planning Committee

2009-2012 University of Colorado School of Medicine Promotions Committee, Co-Chair 2012

2012-2015 AHA Hospital Certification Science Committee

LICENSURE AND BOARD CERTIFICATIONS:

Pennsylvania (Inactive) MD-030075-E

Bureau of Professional and Occupational Affairs

P.O. Box 2649, Harrisburg, PA 17105-2649

Louisiana (Inactive) 07604R

Louisiana State Board of Medical Examiners

P.O. Box 30250, New Orleans, LA 70190-0250

Colorado (Active) 0027568

Colorado Medical Board

1560 Broadway, Denver, CO 80202-5140

Wyoming (Active) 11208A

Wyoming Board of Medicine

130 Hobbs Avenue, Suite A\Cheyenne, WY 82002

LOBBYING:

Washington DC: 1995, 2000, 2002 with the American Academy of Neurology, the American Heart

Association and the Colorado Society of Clinical Neurologists

COLORADO STROKE BILL:

Jack Pommer, then aide to Boulder House Representative Todd Saliman, and the AHA Desert Mountain

Affiliate Stroke Committee (Chair, Richard L. Hughes, MD.) wrote this legislation. The bill passed in March

2002 by both the Colorado House and Senate after testimony by Richard L. Hughes, MD among others.

Governor Bill Owens signed the bill into law in May 2002. This legislation has set up a statewide advisory

board on stroke policy through the Colorado Department of Public Health and Environment, now the

Colorado Stroke Alliance. There is now a Stroke Registry in Colorado, including the University of Colorado

Hospital and Denver Health Medical Center.


PRIMARY STROKE CENTER CERTIFICATIONS:

The JCAHO Disease specific certification process has collaborated with the ASA, via the ASA Advisory

Committee (Richard L. Hughes, MD, member) and the ASA Primary Stroke Center Certification Sub-

Committee (Richard L. Hughes, MD, member).

COMPREHENSIVE STROKE CENTER CERTIFICATION:

In the summer of 2005, the Comprehensive Stroke Center (CSC) guidelines were published and the ASA

committee for CSC was formed (Richard L. Hughes, MD, member). Drs. Richard L. Hughes and Anthony

Furlan have presented their analysis of what key factors constitute a CSC and distinguish the CSC from a

PSC. These recommendations will be carried forward with other specialty organizations.

BOARD EXAMINER:

National Board of Medical Examiners, Parts I, II, III Neurology Board Certified 1988

Neurology Board Examiner (1990, 95, 99, 00, 00, 01, 01, 03)

Diplomat, Vascular Neurology 2005, & 2015

REVIEWER:

Circulation

International Journal of Stroke

Journal of Neuro-Ophthalmology

Journal of Stroke and Cerebrovascular Disease

National Stroke Association

Stroke

The Neurologist

INTERNATIONAL INVITED SPEAKING:

DATE: LOCATION: TITLE:

December 2016 Nassau, Bahamas Neurology Selected Topics

December 2015 Brussels, Belgium First European Fibromuscular Dysplasia

Conference

January 2015 St. Maarten Neurology for the Primary Care Provider

October 2006 Stroke Society of Australasia,

Adelaide, Australia

Comp Stroke Certification

May 2006 University of Heidelberg, Germany Visiting Professor

September 2002 Stroke Society of Australasia,

Queensland, Australia

Stroke Panelist / North America

December 2001 Train to End Stroke, Jamaica Speaker / Chair


October 1998 Boehringer-Ingelheim, Crete, Greece Advisory Panel

September 1994 Janssen, Toronto, Canada Stroke Resuscitation

July 1994 HCI, Glasgow, Scotland Visiting Professor

NATIONAL AND REGIONAL INVITED SPEAKING:

DATE: LOCATION: TOPIC: COURSE:

November 2017 Maui, HI Speaker Neurology for the PCP

June 2017 Los Angeles, CA Speaker Neurology for the PCP

April 2017 Las Vegas, NV Speaker Neurology for the PCP

February 2017 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies

March 2016 Kona, HI Headache Vertigo;

Neuropathic Pain

Neurology Updates for Internists

Stroke:


February 2016 Beaver Creek, CO NIH IRIS Trial


February 2015 Beaver Creek, CO Updates in Stroke 2015


October 2013 Princeville, HI Neurology for the PCP Series of four talks


October 2012 Albuquerque, NM Comprehensive Stroke Western States Stroke

Consortium

June 2012 Estes Park, CO Neurology Update Family Medicine Review

February 2012 Beaver Creek, CO Stroke Call-Fleming Syndrome


July 2011 Estes Park, CO Neurology Update Internal Medicine Review


September 2010 Denver, CO Stroke Internal Medicine

September 2010 Albuquerque, NM Comprehensive Stroke Western States Stroke

Consortium


July 2009 Estes Park, CO Stroke Update Internal Medicine Review

June 2009 Estes Park, CO Seizures Family Medicine Review

November 2008 Denver, CO Stroke Update Family Medicine Review

October 2008 Boulder, CO Atherosclerosis AHA Prevention Series

June 2008 Estes Park, CO Stroke Update Family Medicine Review


November 2007 Denver, CO Stroke Update Family Medicine Review

June 2007 Estes Park, CO Stroke Update Internal Medicine

March 2007 Denver Health Intracerebral Hemorrhage CME Course

February 2007 Vail, CO Statins in Cerebrovascular

Disease

Neurosurgery in the Rockies

February 2007 Vail, CO *Co-Director Neurosurgery in the Rockies

October 2006 Barrow Neurological

Institute, Phoenix, AZ

Cavernous Hemangiomas Speaker

April 2006 Denver, CO Stroke in Women Go Red for Women

February 2006 Vail, CO *Co-Director Neurosurgery in the Rockies

February 2006 Breckenridge, CO CSC in USA Vista Investigators

February 2006 Denver, CO Stroke in Women CV Summit for Women


February 2006 Vail, CO Neurological injuries Neurology Retreat

April 2004 Denver, CO AJA/JCAHO Stroke Update

January 2004 Portland, OR ASA/JCAHO Stroke Center

January 2004 Montrose, CO Stroke Update UCHSC Outreach

October 2003 Denver, CO Hypothermia DHMC ICU

September 2003 Denver, CO Stroke UCHSC UCHSC Rehabilitation

April 2003 Denver, CO Stroke UCHSC Cardiology

December 2002 Denver, CO Stroke Neurology Journal Club

December 2002 Denver, CO Stroke UCHSC OB/GYN

September 2002 Los Angeles , CA Stroke Legislation Western States Stroke

Consortium

September 2002 Estes Park, CO Stroke Workshop AHA/ACLS

September 2002 Estes Park, CO ACLS-Stroke AHA

April 2002 Denver, CO Update ASA Seminar

February 2002 San Antonio, TX ASA/ISM Annual ASA Update

June 2001 Denver, CO Stroke Imaging ACVIM

June 2001 Kona, HI Stoke Volunteer TTES

May 2001 Littleton, CO Stroke Update RMSA

November 2000 Boulder, CO Stroke Prevention Panel

October 2000 Estes Park, CO Operation Stroke AHA

September 2000 Aspen, CO Operation Stroke WSSC

September 2000 Denver, CO Stroke Update RMSA

August 2000 Denver, CO Stroke Family Medicine

August 2000 Denver, CO Brain Localization Neuropsychiatry

August 2000 Denver, CO Stroke Update Lutheran

August 2000 Meeker, CO Stroke Resuscitation CASN/AHA

July 2000 Estes Park, CO Stroke Update Internal Medicine

June 2000 Bryn Mawr, PA Stroke Outcome Rehabilitation

May 2000 Phoenix, AZ Stroke Resuscitation AHA

March 2000 Aspen, CO Stroke Resuscitation CASN/AHA

November 1999 Denver, CO Operation Stroke AHA Board

October 1999 DHNC Stroke Resuscitation Medicine Research

September 1999 Snowmass, CO Atrial Fibrillation NSA Seminar

July 1999 Aspen, CO Thrombolytic UC-CME

March 1999 Snowmass, CO *Session Co-Chair NANOS

January 1999 DHMC Migraine Emergency Medicine

October 1998 Denver, CO Stroke Success RMSA

September 1998 Los Angeles, CA CASN RMSA

May 1998 Denver, CO *Anti-Thrombotic

Therapy

Course Director

April 1998 Ft. Lauderdale, FL Stroke Resuscitation NSA Seminar

February 1998 Jackson, WY Stroke St. John’s Hospital

February 1998 Denver, CO Stroke UC-CME

November 1997 Denver, CO Carotid Disease Vascular Grand Rounds

October 1997 Denver, CO Stroke Resuscitation AAN Seminar

October 1997 Boise, ID Stroke Resuscitation NSA Seminar

October 1997 Colorado Springs Headache Military Physicians

August 1997 Albuquerque, NM Stroke Resuscitation Neurology Grand Rounds


August 1997 Denver, CO Carotid Disease Medicine Grand Rounds

July 1997 Denver, CO Reperfusion Injury Grand Rounds

June 1997 Evanston, WY Thrombolytics CASN/AHA Series

May 1997 Riverton, WY Thrombolytics CASN/AHA Series

May 1997 Lander, WY Thrombolytics CASN/AHA Series

May 1997 Denver, CO CASN CASN Teleconference

March 1997 Denver, CO Stroke Resuscitation St. Joseph’s Grand Rounds

February 1997 Cody, WY Thrombolytics CASN/AHA Series

February 1997 Jackson, WY Thrombolytics CASN/AHA Series

January 1997 Vail, CO Thrombolytics Emergency Medicine

December 1996 Cheyenne, WY Thrombolytics CASN/AHA Series

November 1996 Farmington, NM Thrombolytics in Stroke CASA/AHA Series

October 1996 Casper, WY Thrombolytics in Stroke CASN/AHA Series

October 1996 Denver, CO Stroke Medicine CPC

July 1996 Estes Park, CO Stroke Resuscitation IM Review Course

June 1996 Colorado Springs, CO *Session Co-Chair NSA-North American

March 1996 Denver, CO Stroke Geriatric Course

January 1996 Denver, CO Headache and Epilepsy Seminar

June 1995 Denver, CO *Session Co-Chair NSA Seminar

September 1994 Denver, CO Stroke Colorado Nursing

July 1994 Marshfield, WI FMD Clinical Grand Rounds

April 1994 Palm Springs, CA Stroke NSA Seminar

March 1994 Breckenridge, CO Stroke Geriatric Review Course

January 1994 Denver, CO Stroke Fitzsimmons

July 1993 Estes Park, CO Stroke IM Review Course

April 1993 New Orleans, LA Carotid Disease Ochsner Course

January 1993 Loveland, CO Stroke McKee Medical Center

July 1992 Denver, CO Keynote Address Rehabilitation Seminar

May 1992 Denver, CO Thrombolytic Therapy CSCN

March 1992 Winter Park, CO Stroke Geriatric

November 1990 New Orleans, LA Stroke Geriatric

September 1990 New Orleans, LA Resuscitation Tulane Neurology

April 1990 New Orleans, LA FMD Tulane Neurology

February 1990 New Orleans, LA Atypical TIA Vascular Surgery

RECENT UNIVERSITY OF COLORADO GRAND ROUNDS:

“Cerebrovascular Disease Gone Viral”

“The Emerging use of Statins in Cerebrovascular Disease”

“Carotid Endarterectomy: An Emerging Consensus Fibromuscular Dysplasia”

“Polycystic Kidney Disease and Intracranial Aneurysms”

“CNS Vasculitis Thrombolytic Therapy in Acute Stroke New Directions in Stroke Resuscitation”

“Are You Ready for Combination Therapy?”

“Unruptured Intracranial Aneurysms”


“Iatrogenic Complications of Stroke Therapy”

“Advocacy, Lobbying, and the 2002 Colorado Stroke Bill “

“The Spectrum of Moya-Moya Disease in the Adult”

“Are You Ready For Stroke Center Certification?”

“Stroke Retrospective 1986-2006”

“Susac’s Syndrome”

“Call-Fleming Syndrome”

“Reducing Cardiac Embolization to the Brain: Are We Getting Near the Finish Line?”

“Insulin Resistance in Stroke Prevention: The NIH IRIS Trial Results”

REGULAR CONFERENCE TALKS:

Acute Neurology Series, UCHSOM

MS2 Neuropathology Course, UCSOM

MS4 Pharmacology, UCSOM (winter)

Residency Core Topics, UCSOM (on-going)

Resident Noon Reports

Stroke Fellow Weekly Core Lecture Series

Stroke Update for Internal Medicine, UCH & DHMC

MEDIA:

DATE: MEDIUM: TOPIC:

2010 Channel 31 Fox – Kim Posey Meningitis

2009 Fitness Magazine Fibromuscular Dysplasia

2007 Stroke Connection Fibromuscular Dysplasia

2004 Channel 31 Fox – Kim Posey “Brain Matters”

2004 Rocky Moun6tain News Migraines

2001 Bottom Line “Stroke Self-Defense”

2001 Channel 2 “Hyperbaric Oxygen in Stroke”

2001 KUSA TV “Train to End Stroke”

2000 KUSA TV “Operation Stroke”

2000 NSA Audio Tape and CD Stroke Guidelines

1999 KUSA Radio Atrial Fibrillation

1999 Fox Television News Hypothermia

1999 Bottom Line Magazine Atrial Fibrillation

1999 Tomorrow Magazine Atrial Fibrillation


1999 Bottom Line Magazine Facial Tics

1999 Stroke-CD NSA

1999 USA Today Stroke Prevention

1999 NSA Video Stroke

1998 Prevention Magazine Atrial Fibrillation

1998 NSA-SCN-Audio Teleconference Moderator

1997 KUSA TV “Taco Neck”

1997 KUSA TV “Pokeman” Induced Seizures

1997 Internal Medicine News Minimum Requirements for TPA Use

1997 Boulder Daily Camera Stroke

1996 Denver Post Aneurysm

1996 AARP Video Stroke

1993 National Stroke Association, 1994

20 minute video

Stroke: The Story of Treatment and

Recovery. A 20-minute video, discussing

aspects of treatment and prognosis after a

stroke. Featuring Dr. Richard Hughes

and stroke-survivor Jackie Meyer-

Townsend, Miss America 1963

STUDY CONSULTING:

Amgen: Data Management and Safety Committee. Stem Cell treatment after Stroke 2010-2012

Nestle Life Sciences: Advisory Committee. Dysphagia 2015-present

STUDY PARTICIPATION:

Grants and Funding

Funding Source (estimate) Multi-Center Studies

NIH / Yale 2005-2013 Insulin Resistance Intervention After Stroke (IRIS)

Richard L. Hughes MD (PI Denver)

NIH ($275,000) Warfarin Versus Aspirin in Reduced Ejection Fraction (WARCEF)

2003-2012 Richard L. Hughes MD (PI Denver)

Lilly USA, LLC Duloxetine in Patients with Central Neuropathic Pain in Multiple Sclerosis -


Merck Thrombin Receptor Antagonist in Secondary Prevention of

Atherothrombotic Ischemic Events (TRASP)


Boehringer-Ingelheim Prevention Regimen for Effectively Avoiding Second Strokes

2003-2008 ($120,000) (PROFESS) - Richard L. Hughes MD (PI Denver)

Parke-Davis ($40,000) Stroke Prevention by Aggressive Reduction in Cholesterol levels

1999-2004 (SPARCL) - Richard L. Hughes MD (PI Denver)

Novo Nordisc ($10,000) Factor VII in Treatment of Cerebral Hemorrhage (FAST)


NIH ($138,576) Vitamin Intervention in Stroke Prevention (VISP)



Genentech ($60,000) Thrombolytic Therapy in Acute Ischemic Stroke

1992-2000 ATLANTIS - Richard L. Hughes MD (PI Denver)

NIH ($20,000) International Study of Unruptured Intracranial Aneurysms (ISUIA)


HCFA $0 Appropriateness of Carotid Endarterectomy

Richard L. Hughes MD - Panelist

Jannsen terminated PACT (Prosynap Alteplase Combined Therapy)


ICOS terminated HU23F26 Anti-adhesion to Limit Cytotoxic Injury in Stroke (HALT)


Lorex ($17,000) Eliprodil in Ischemic Stroke (1995-1997)


Santofi ($150,000) Clopidigrel vs. Aspirin in Prevention of Recurrent Ischemic Events

1992-1997 (CAPRIE) - Richard L. Hughes MD (PI Denver)

NIH ($12,000) Asymptomatic Carotid Atherosclerosis Study (ACAS)

1989-1991 Ochsner Richard L. Hughes MD (PI New Orleans)

Miles ($55,000) Nimodipine Stroke Study

1988-1990 Richard L. Hughes MD (PI New Orleans)

AUTHORIZED AND CONSORTIUM PUBLICATIONS:

1. Hughes RL: Medical overview of brain death. Health Care Review; 3(1):6-9, 1986

2. Hughes RL, Katirji B: The Eaton-Lambert (Myasthenic) Syndrome in Association with Systemic Lupus

Erythematosus. Arch Neurol 43:1186-87, 1986

3. Rosenberg NL, Hughes RL: Meningovascular Syphilis in a Young Homosexual Man. Arch Neurol

1989; 46:10-11

4. Hughes RL, Yonas H, Gur D, Latchaw R: Cerebral blood flow determination within the first 8 hours of

cerebral infarction using stable Xenon-enhanced computed tomography. Stroke 1989; 20:754-760

5. The Hemodilution in Stroke Study Group: Hypervolemic hemodilution treatment of acute stroke.

Results of a randomized multicenter trial using pentastarch. Stroke 1989 Mar; 20(3):317-23. (Hughes

RL, Denver)

6. Hass WK, Easton JD, Adams HP, Pryse-Phillips W, Molony BA, Anderson S, Kamm B: For the

Ticlopidine Aspirin Stroke Study Group. A randomized trial comparing ticlopidine hydrochloride with

aspirin for the prevention of stroke in high-risk patients. NEJM 1989; 321:501-507. (Hughes RL,

Pittsburgh and Denver)


7. Hughes RL: Identification and treatment of unruptured cerebral aneurysm after sentinel headache:

Report of two cases. Neurology 1992; 42:1118-1119

8. Chapman AB, Rubinstein DR, Hughes RL, Stears JC, Earnest MP, Johnson AM, Gabow PA and

Kaehny WD: Intracranial aneurysms in autosomal dominant polycystic kidney disease: A prospective

study. NEJM 1992; 327:916-920

9. The American Nimodipine Study Group: Clinical Trial of Nimodipine in Acute Ischemic Stroke.

Stroke 1992; 23:3-8 (Hughes RL, Primary Investigator, Ochsner Clinic)

10. McCrory DC, Goldstein LB, Sands GP, Oddone ET, Landsman PB, Moore WS, Matchar DB: Predicting

complications of carotid endarterectomy. Stroke 1993; 24:1285-1291. (Hughes RL, Alton Ochsner

Medical Foundation)

11. Goldstein LB, McCrory DC, Landsman PB, Samsa GP, Ancukiewicz M, Oddone EZ, Matchar DB:

Multicenter review of preoperative risk factors for carotid endarterectomy in patients with ipsilateral

symptoms. Stroke 1994; 25:1116-1121. (Hughes RL, Alton Ochsner Medical Foundation)

12. Brott T, Tomick T, Feinberg W, Johnson C, Biller J, Broderick J, Kelly M, Frey J, Schwartz S, Blum C,

Nelson JJ, Chambless L, Toole J, for the Asymptomatic Carotid Atherosclerosis Study Investigators:

Baseline Silent Cerebral Infarction in the Asymptomatic Carotid Atherosclerosis. Stroke 1994; 25:1116-

1121. (Hughes RL, Primary Investigator, Oschner Clinic, New Orleans, LA)

13. The Asymptomatic Carotid Atherosclerosis (ACAS) Study Group. Endarterectomy for Asymptomatic

Carotid Artery Stenosis. JAMA 273:1421-1428 1995; (Hughes, RL, Primary Investigator, Oschner

Clinic, New Orleans, LA)

14. Howard G, Baker WH, Chambless LE, Howard V, Jones AM, Toole JF, for the Asymptomatic Carotid

Atherosclerosis Study Investigators: An Approach for the Use of Doppler Ultrasound as a Screening

Tool for Hemodynamically Significant Stenosis (Despite Heterogeneity of Doppler Performance). Stroke

1996; 27:1951-1957. (Hughes RL, Primary Investigator, Oschner Clinic, New Orleans, LA)

15. Young B, Moore WS, Robertson JT, Toole JF, Ernst CB, Cohen SN, Broderick JP, Dempsey RJ,

Hosking JD; for the ACAS Investigators: An Analysis of Perioperative Surgical Mortality and

Morbidity in the Asymptomatic Carotid Atherosclerosis Study. Stroke 1996; 27:2216-2224. (Hughes

RL, Primary Investigator, Oschner Clinic, New Orleans, LA)

16. CAPRIE steering Committee: A randomized, blinded, trial of clopidogrel versus aspirin in patients at

risk of ischemic events (CAPRIE). Lancet 1996; 348:1329-1338. (Hughes RL, Primary Investigator,

Denver)

17. Ringel SR, Hughes RL: Evidence-based medicine, critical pathways, practice guidelines, and managed

care, reflections on the prevention and care of stroke. Arch Neurol 1996; 53:867-871

18. Karanjia PN, Nelson JJ, Lefkowitz DS, Dick AR, Toole JF, Chamblers LE, Hayes R, Howard VJ:

Validation of the ACAS TA/Stroke Algorithm. Neurology 1997; 48:346-351 (Hughes RL, University of

Colorado)

19. Moore WS, Kempczinski RF, Nelson JJ, Toole JF, for the ACAS Investigators: Recurrent Carotid

Stenosis Results of the Asymptomatic Carotid Atherosclerosis Study: Stroke 1998; 29:2018-2025.

(Hughes RL, Primary Investigator, Ochsner Clinic, New Orleans, LA)


20. Alberts MJ, Chaturvedi S, Graham G, Hughes RL, Jamieson DG, Krakowski F, Raps E, Scott P, for the

National Acute Stroke Team Group. Acute Stroke Teams: Results of a national survey. Stroke 1998;

29:2318-20

21. International Study of Unruptured Intercranial Aneurysms (ISUIA) Investigators: Unruptured

intracranial aneurysms. Risk of rupture and surgery. NEJM 1998; 339:1725-33. (Hughes RL, Primary

Investigator, Denver)

22. Munschauer FE, Hens MM, Priore RL, Stolarski E, Buffamonte S, Carlin A, Wechsler L, Massaro L,

Barch C, Hughes RL, Anderson A, Sung G, Baker S, Limon S: Screening for atrial fibrillation in the

community: A multicenter validation trial. J Stroke and Cerebrovascular Dis 1999; 8:99-103

23. Kramer AM, Kowalsky L, Cahill J, Lin M, Grigsby J, Hughes RL, and Steiner JF: Outcome and

utilization differences for older persons with stroke in HMO and fee-for-service systems. J Am Geriatr

Soc 2000; 48:726-734

24. Clark WM, Albers GW, Madden KP, Hamilton S: The rtPA 0-to 6-hour acute stroke trial, part A

(A0276g) results of a double-blind, placebo-controlled, multicenter study. Stroke 2000; 31:811-816.)

(Hughes RL, Primary Investigator, Denver)

25. Spence JD, Howard VJ, Chambless LE, Malinow MR, Pettigrew LC, Stampfer M, Toole JF for the VISP

Investigators: Vitamin Intervention for Stroke Prevention (VISP) Trial: Rationale and Design.

Neuroepidemiology 2001; 20:16-25

26. Belz MM, Hughes RL, Kaehny WD, Johnson AM, Fick-Brosnahan GM, Earnest MP, Gabow PA:

Familial Custering of Ruptured Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney

Disease. American Journal of Kidney Diseases 2001; 38:770-776

27. Hughes RL: Multidisciplinary Consensus Recommendations from the Advisory Working Group on

Stroke Center Identification Options of the American Stroke Association. Recommendations for

Improving the Quality of Care through Stroke Centers and Systems: An Examination of Stroke Center

Identification Options. Stroke 2002; 33:e1-e7

28. Belz MM, Godela M, Fick-Brosnahan GM, Hughes RL, Rubinstein D, Chapman AB, Johnson AM,

McFann KK, M.Div., Kaehy WD, Gabow PA: Recurrence of Intracranial Aneurysms in Autosomal

Dominant Polycystic Kidney Disease. Kidney International 2003; 63:1824-30

29. D.A. Hall, MD, C.A. Anderson, MD, C.M. Filley, MD, J Newcombe, MA, C.C.C.S.L.P, Hughes RL: A

French Accent after an Infarct in the Corpus Callosum. Neurology 2003; 60:1551-2

30. Hughes RL, Halm EA, Chassin MR, Tuhrim S, Hollier LH, Popp AJ, Ascher E, Dardik H, Faust G,

Riles TS: Revisiting the Appropriateness of Carotid Endarterectomy. Stroke 2003; 34:1464-1472

31. Englander J, Bushnik T, Duong TT, Cifu D, Zafonte R, Wright J, Hughes RL, Bergman W: Analyzing

risk factors for late posttraumatic seizures: a prospective multicenter study. Arch Phys Med Rehabil

2003; 84:365-73

32. Amarenco P, Bobousslavsky J, Callahan AS, Goldstein L, Hennerici M, Sillsen H, Welch MA, Zivin J,

SPARCL Investigators: Design and baseline characteristics of stroke prevention by aggressive

reduction in cholesterol levels (SPARCL). Cerebrovasc Dis 2003; 16:389-95


33. Weibers D, and the International Study of Unruptured Intracranial Aneurysm Investigators:

Unruptured intracranial aneurysms: natural history, clinical outcome, and risk of surgical and

endovascular treatment. Lancet 2003; 362:103-110

34. Toole JF, Malinow MR, Chambless LE, Spence JD, Spence LC, Pettigrew LC, Howard VJ, Sides EG,

Wang CH, Stampfer M: Lowering homocysteine in patients with ischemic stroke to prevent recurrent

stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP)

randomized controlled trial. JAMA 2004; 291:565-75. (Hughes RL, Denver)

35. Shrier RW, Belz MM, Johnson AM, Kaehny WD, Hughes RL, Rubinstein D, Gabow PA: Repeat

Imaging for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease

with Initially Negative Studies: A Prospective Ten-Year Follow-up. J Am Soc Nephrol 2004, Volume

15, 1023-8

36. The Stroke Prevention by Aggressive Reduction in Cholesterol SPARCL Investigators: High-Dose

Atorvastatin after Stroke or Transient Ischemic Attack. NEJM 2006; 355:549-559

37. Pullicino P, Thompson JL, Barton B, Levin B, Graham S, Freudenberger RS, WARCEF Investigators:

Warfarin versus aspirin in patients with reduced cardiac ejection fraction (WARCEF): rationale,

objectives, and design. J Card Fail 2006 Feb; 12(1):39-46

38. Amarenco P, Goldstein LB, Szarek M, Sillesen H, Rudolph AE, Callahan A III, Hennerici M, Simunovic

L, Zivin JA, Welch MA on behalf of the SPARCL Investigators: Effects of Intense Low-Density

Lipoprotein Cholesterol Reduction in Patients with Stroke or Transient Ischemic Attack: The Stroke

Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial Stroke 2007; 38:3198-3204

39. Kluger BM, Hughes RL, Anderson CA, Hassell KL: Non-traumatic carotid dissection and stroke

associated with anti- phospholipid antibody syndrome: Report of a case and review of the literature.

Neurol India 2008; 56:77-8

40. Ralph L. Sacco, MD, Hans Christoph Diener, MD, PhD, Salim Yusuf, MB, BS, D. Phil, Daniel Cotton,

MS, Stephanie Ôunpuu, PhD, William A. Lawton, BA, Yuko Palesch, PhD, Reneé H. Martin, PhD,

Gregory W. Albers, MD, Philip Bath, FRCP, Natan Bornstein, MD, Bernard P.L. Chan, MD, Sien-Tsong

Chen, MD, Luis Cunha, MD, PhD, Björn Dahlöf, MD, PhD, Jacques De Keyser, MD, PhD, Geoffrey A.

Donnan, MD, Conrado Estol, MD, PhD, Philip Gorelick, MD, Vivian Gu, MD, Karin Hermansson,

DMSc, Lutz Hilbrich, MD, Markku Kaste, MD, PhD, Chuanzhen Lu, MD, Thomas Machnig, MD, Prem

Pais, MD, Robin Roberts, M.Tech, Veronika Skvortsova, MD, Philip Teal, MD, Danilo Toni, MD, Cam

VanderMaelen, PhD, Thor Voigt, MD, Michael Weber, MD, Byung-Woo Yoon, MD, PhD, for the

PROFESS Study Group*: Aspirin and Extended-Release Dipyridamole versus Clopidogrel for

Recurrent Stroke. N Engl J Med 2008; 359:1238-1251

41. Salim Yusuf, MB, BS, D. Phil, Hans-Christoph Diener, MD, PhD, Ralph L. Sacco, MD, Daniel Cotton,

MS, Stephanie Ôunpuu, PhD, William A. Lawton, BA, Yuko Palesch, PhD, Reneé H. Martin, PhD,

Gregory W. Albers, MD, Philip Bath, FRCP, Natan Bornstein, MD, Bernard P.L. Chan, MD, Sien-Tsong

Chen, MD, Luis Cunha, MD, PhD, Björn Dahlöf, MD, PhD, Jacques De Keyser, MD, PhD, Geoffrey A.

Donnan, MD, Conrado Estol, MD, PhD, Philip Gorelick, MD, Vivian Gu, MD, Karin Hermansson,

DMSc, Lutz Hilbrich, MD, Markku Kaste, MD, PhD, Chuanzhen Lu, MD, Thomas Machnig, MD, Prem

Pais, MD, Robin Roberts, M.Tech., Veronika Skvortsova, MD, Philip Teal, MD, Danilo Toni, MD, Cam

VanderMaelen, PhD, Thor Voigt, MD, Michael Weber, MD, Byung-Woo Yoon, MD, PhD, for the

PROFESS Study Group: Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events N Eng J

Med 2008; 359:1225-1237


42. Larry B. Goldstein, MD; Pierre Amarenco, MD; Marian LaMonte, MD; Steven Gilbert, PhD; Michael

Messig, PhD; Alfred Callahan, MD; Michael Hennerici, MD, PhD; Henrik Sillesen, MD, MSc; K.

Michael A. Welch, MB, ChB on behalf of the SPARCL Investigators: Relative Effects of Statin

Therapy on Stroke and Cardiovascular Events in Men and Women: Secondary Analysis of the Stroke

Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study. Stroke 2008: 39:2444-

2448

43. Henrik Sillesen, Pierre Amarenco, Michael G. Hennerici, Alfred Callahan, Larry B. Goldstein, Justin

Zivin, Michael Messig, Michael Welch on Behalf of the SPARCL Investigators: Atorvastatin Reduces

the Risk of Cardiovascular Events in Patients with Carotid Atherosclerosis: A Secondary Analysis of the

Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial. Stroke 2008;

39:3297-3302

44. L. B. Goldstein, MD, P. Amarenco, MD, M. Szarek, MS, A. Callahan, III, MD, M. Hennerici, MD, PhD,

H. Sillesen, MD, DMSc, J. A. Zivin, MD, PhD, K.M.A. Welch, MD, PhD on behalf of the SPARCL

Investigators: Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol

Levels study. Neurology 2008; 70:2364-2370

45. Chaturvedi S, Zivin J, Beazna Amarenco P, Callahan A, Goldstein LB, Hennerici M, Sillesen H,

Rudolph A, Welch MA on behalf of the SPARCL Investigators: Effect of atorvastatin in elderly

patients with a recent stroke or transient ischemic attack. Neurology 2009; 72:688-694

46. Pierre Amarenco, Oscar Benavente, Larry B. Goldstein, Alfred Callahan, III, Henrik Sillesen, Michael

G. Hennerici, Steve Gilbert, Amy E. Rudolph, Lisa Simunovic, Justin A. Zivin, K. Michael A. Welch on

behalf of the SPARCL Investigators: Results of the Stroke Prevention by Aggressive Reduction in

Cholesterol Levels (SPARCL) Trial by Stroke Subtypes. Stroke 2009; 40:1405-1409

47. Larry B. Goldstein, Pierre Amarenco, Justin Zivin, Michael Messig, Irfan Altafullah, Alfred Callahan,

Michael Hennerici, Mary J. MacLeod, Henrik Sillesen, Richard Zweifler, K. Michael, A. Welch on

behalf of the SPARCL Investigators: Statin Treatment and Stroke Outcome in the Stroke Prevention by

Aggressive Reduction in Cholesterol Levels (SPARCL) Trial. Stroke 2009; 40:3526-3531

48. Philip M. W. Bath, Reneé H. Martin, Yuko Palesch, Daniel Cotton, Salim Yusuf, Ralph Sacco, Hans-

Christoph Diener, Danilo Toni, Conrado Estol, Robin Roberts for the PROFESS Study Group: Effect

of Telmisartan on Functional Outcome, Recurrence, and Blood Pressure in Patients With Acute Mild

Ischemic Stroke: A PROFESS Subgroup Analysis. Stroke 2009; 40:3541-3546

49. Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR,

Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W; ECASS, ATLANTIS, NINDS and

EPITHET rt-PA Study Group, Allen K, Mau J, Meier D, del Zoppo G, De Silva DA, Butcher KS,

Parsons MW, Barber PA, Levi C, Bladin C, Byrnes G. for the ECASS, ATLANTIS, NINDS and

EPITHET rt-PA Study Group Investigators: Time to treatment with intravenous alteplase and

outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.

Lancet 375:1695-1703, 15 May 2010; Collaborators (752)

50. Bath PM, Cotton D, Martin RH, Palesch Y, Yusuf S, Sacco R, Diener HC, Estol C, Roberts R;

PROFESS Study Group: Effect of combined aspirin and extended-release dipyridamole versus

clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PROFESS subgroup

analysis. Stroke 2010 Apr; 41(4):732-8


51. Ovbiagele B, Diener HC, Yusuf S, Martin RH, Cotton D, Vinisko R, Donnan GA, Bath PM; PROFESS

Investigators: Level of systolic blood pressure within the normal range and risk of recurrent stroke.

JAMA 2011 Nov 16; 306(19):2137-44

52. Weber R, Weimar C, Wanke I, Möller-Hartmann C, Gizewski ER, Blatchford J, Hermansson K,

Demchuk AM, Forsting M, Sacco RL, Saver JL, Warach S, Diener HC, Diehl A; PROFESS Imaging

Substudy Group: Risk of recurrent stroke in patients with silent brain infarction in the Prevention

Regimen for Effectively Avoiding Second Strokes (PROFESS) imaging substudy. Stroke 2012 Feb;

43(2):350-5. Epub 2012 Jan 19

53. Braun CN, Hughes RL, Bosque PJ: Reversible Cerebral Vasoconstriction Syndrome 3 Months after

Blood Transfusion. J Stroke Cerebrovasc Dis. 2012 Feb 15. [Epub ahead of print]

54. David A. Morrow, M.D., M.P.H., Eugene Braunwald, M.D., Marc P. Bonaca, M.D., Sebastian F.

Ameriso, M.D., Anthony J. Dalby, M.B., Ch.B., Mary Polly Fish, B.A., Keith A.A. Fox, M.B., Ch.B.,

Leslie J. Lipka, M.D., Ph.D., Xuan Liu, Ph.D., José Carlos Nicolau, M.D., Ph.D., A.J. Oude Ophuis,

M.D., Ph.D., Ernesto Paolasso, M.D., Benjamin M. Scirica, M.D., M.P.H., Jindrich Spinar, M.D., Ph.D.,

Pierre Theroux, C.M., M.D., Stephen D. Wiviott, M.D., John Strony, M.D., and Sabina A. Murphy,

M.P.H. for the TRA 2P–TIMI 50 Steering Committee and Investigators: Vorapaxar in the Secondary

Prevention of Atherothrombotic Events. N Engl J Med 2012; 366:1404-1413 April 12, 2012

55. Shunichi Homma, M.D., John L.P. Thompson, Ph.D., Patrick M. Pullicino, M.D., Bruce Levin, Ph.D.,

Ronald S. Freudenberger, M.D., John R. Teerlink, M.D., Susan E. Ammon, N.P., Susan Graham, M.D.,

Ralph L. Sacco, M.D., Douglas L. Mann, M.D., J.P. Mohr, M.D., Barry M. Massie, M.D., Arthur J.

Labovitz, M.D., Stefan D. Anker, M.D., Ph.D., Dirk J. Lok, M.D., Piotr Ponikowski, M.D., Ph.D.,

Conrado J. Estol, M.D., Ph.D., Gregory Y.H. Lip, M.D., Marco R. Di Tullio, M.D., Alexandra R.

Sanford, M.S., Vilma Mejia, B.S., Andre P. Gabriel, M.D., Mirna L. del Valle, B.S., and Richard

Buchsbaum for the WARCEF Investigators: Warfarin and Aspirin in Patients with Heart Failure and

Sinus Rhythm. N Engl J Med 2012; 366:1859-1869 May 17, 2012

56. David A. Morrow, Mark J. Alberts, Jay P. Mohr, Sebastian F. Ameriso, Marc P. Bonaca, Shinya Goto,

Graeme J. Hankey, Sabina A. Murphy, Benjamin M. Scirica, and Eugene Braunwald, for the Thrombin

Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering

Committee and Investigators: Efficacy and Safety of Vorapaxar in Patients with Prior Ischemic Stroke.

Stroke 2013; 44:691-698, published online before print February 8 2013,

doi:10.1161/STROKEAHA.111.000433

57. Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, Gorman M, Guarino PD, Inzucchi SE,

Lovejoy AM, Parsons MW, Peduzzi PN, Ringleb P, Schwartz GG, Spence JD, Tanne D, Young LH,

Kernan WN on behalf of the IRIS Trial Investigators: Pioglitazone for secondary prevention after

ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance

Intervention after Stroke (IRIS). Am Heart J 2014:168:823-829

58. Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, Gorman M, Guarino PD, Inzucchi SE,

Lovejoy AM, Parsons MW, Peduzzi PN, Ringleb PA, Schwartz GG, Spence JD, Tanne D, Young LH,

Kernan WN, IRIS Trial investigators: Pioglitazone for secondary prevention after ischemic stroke and

transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial.

Am Heart J. (2014)

59. Case D, Seinfeld J, Folzenlogen Z, Simpson J, Hughes RL: Acute posterior Multifocal Placoid Pigment

Epitheliopathy associated with Stroke: A Case Report and review. Journal of Stroke and Cerebrovascular

Diseases 2015 24:e295-302

https://www.ncbi.nlm.nih.gov/pubmed/25458644



60. Borah S, McConnell B, Hughes RL, Antoniello D, and Kluger B: Potential Relationship of Self-

Injurious Behavior to Right Temporo-Parietal Lesions. Under Review

61. Keenan WN et al.: Insulin Resistance Intervention in Stroke Trial. N Engl J Med 2016. doi:10:1056/NEJ

Moa1 56930

62. Xu J, Viscoli CM, Ford GA, Gorman M, Kernan WN, IRIS Trial Investigators: A Diagnostic Score for

Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack. J Stroke

Cerebrovasc Dis. 2016 Jul;25(7):1705-1712. doi: 10.1016/j.jstrokecerebrovasdis.2016.03.043. Epub

2016 Apr 11

63. Inzucchi SE, Viscoli CM, Young LH, Furie KL, Gorman M, Lovejoy AM, Dagogo-Jack S, Ismail-Beigi

F, Korytkowski MT, Pratley RE, Schwartz GG, Kernan WN, IRIS Trial Investigators: Pioglitazone

Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care. 2016

Oct;39(10):1684-92. doi: 10.2337/dc16-0798. Epub 2016 Jul 27

64. Viscoli CM, Inzucchi SE, Young LH, Insogna KL, Conwit R, Furie KL, Gorman M, Kelly MA, Lovejoy

AM, Kernan WN, IRIS Trial Investigators: Pioglitazone and Risk for Bone Fracture: Safety Data From

a Randomized Clinical Trial. J Clin Endocrinol Metab. 2017 Mar 1;102(3):914-922. doi:

10.1210/jc.2016-3237. PMID: 27935736; PubMed Central PMCID: PMC5460686

65. Young LH, Viscoli CM, Curtis JP, Inzucchi SE, Schwartz GG, Lovejoy AM, Furie KL, Gorman MJ,

Conwit R, Abbott JD, Jacoby DL, Kolansky DM, Pfau SE, Ling FS, Kernan WN, IRIS Investigators:

Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in

Patients With Insulin Resistance Without Diabetes Mellitus. Circulation. 2017 May 16;135(20):1882-

1893. doi: 10.1161/CIRCULATIONAHA.116.024863

66. Saver JL, Carroll JD, Thaler DE, Smalling RW, MacDonald LA, Marks DS, Tirschwell DL; RESPECT

Investigators: Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.

N Engl J Med. 2017 Sep 14;377(11):1022-1032. doi: 10.1056/NEJMoa1610057

67. Furie KL, Viscoli CM, Gorman M, Ford GA, Young LH, Inzucchi SE, Guarino PD, Lovejoy AM,

Conwit R, Tanne D, Kernan WN; IRIS Trial Investigators: Effects of pioglitazone on cognitive

function in patients with a recent ischaemic stroke or TIA: a report from the IRIS trial. J Neurol

Neurosurg Psychiatry. 2017 Sep 22. pii: jnnp-2017-316361. doi: 10.1136/jnnp-2017-316361

68. Yaghi S, Furie KL, Viscoli CM, Kamel H, Gorman M, Dearborn J, Young LH, Inzucchi SE, Lovejoy

AM, Kasner SE, Conwit R, Kernan WN, IRIS Trial Investigators: Pioglitazone Prevents Stroke in

Patients with a Recent TIA or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial.

Circulation. 2017 Oct 30. pii: CIRCULATIONAHA.117.030458. doi:

10.1161/CIRCULATIONAHA.117.030458

69. Epstein KA, Viscoli CM, Spence JD, Young LH, Inzucchi SE, Gorman M, Gerstenhaber B, Guarino PD,

Dixit A, Furie KL, Kernan WN; IRIS Trial Investigators: Smoking Cessation and Outcome After

Ischemic Stroke or TIA. Neurology 2017 Oct 17;89(16):1723-1729. doi:

10.1212/WNL.0000000000004524. Epub 2017 Sep 8. PubMed PMID: 28887378; PubMed Central

PMCID: PMC5644463

70. Kernan WN, Viscoli CM, Dearborn JL, Kent DM, Conwit R, Fayad P, Furie KL, Gorman M, Guarino

PD, Inzucchi SE, Stuart A, Young LH, IRIS Trial Investigators: Insulin Resistance Intervention After

Stroke: Targeting Pioglitazone Hydrochloride Therapy After Stroke or Transient Ischemic Attack





According to Pretreatment Risk for Stroke or Myocardial Infarction. JAMA Neurol. 2017 Nov

1;74(11):1319-1327. doi: 10.1001/jamaneurol.2017.2136

71. Kernan WN, Viscoli CM, Dearborn JL, Kent DM, Conwit R, Fayad P, Furie KL, Gorman M, Guarino

PD, Inzucchi SE, Stuart A, Young LH, IRIS Trial Investigators: Insulin Resistance Intervention After

Stroke. JAMA Neurol. 2017 Nov 1;74(11):1319-1327. doi: 10.1001/jamaneurol.2017.213

BOOK CHAPTERS:

1. Hughes RL: “CBF Determination Within the First Eight Hours of Cerebral Infarction.” In Yonas HW,

ed. Cerebral Blood Flow Measurement with Stable Xenon-enhanced Computed Tomography. New York:

Raven Press, 1992:121-125

2. Hughes RL: “Neurology.” In Frolich E, ed. Rypian Medical Board Review. Clinical Sciences. 16th

edition. J.P. Lippencott, Philadelphia, 1992

3. Hughes RL, Earnest MP: “Transient Ischemic Attack and Cerebrovascular Accident.” In Markovchick

VJ, Pons PT, and Wolfe RE, eds. Emergency Medicine Secrets. Hanley and Belfur Inc, Philadelphia,

1993

4. Anderson CA, Hughes RL: “Tremor, Common Disorders of the Nervous System.” Primary Care

Secrets. Mosby, 1994, pp 311-313

5. Foley PA, Hughes, RL: “Muscle Weakness, Common Disorders of the Nervous System.” Primary Care

Secrets. Mosby, 1994, pp 313-316

6. Redosh D, Hughes RL: “Numbness and Tingling, Common Disorders of the Nervous System.” Primary

Care Secrets. Mosby, 1994, pp 316-318

7. Villalobos R, Hughes RL: “Cerebrovascular Disorders, Common Disorders of the Nervous System.”

Primary Care Secrets. Mosby, 1994, pp 319-320

8. Hughes RL, Ravilochan K: “Dizziness and Syncope, Common Disorders of the Nervous System.”

Primary Care Secrets. Mosby, 1994, pp 323-326

9. Kumpe D, Hughes RL: “Thrombolytic Therapy for Acute Stroke.” In Whittemore AD ed, Advances in

Vascular Surgery. Mosby, 1996

10. Hughes RL: “Cerebrovascular Disease.” In Jahnigen D, Schrier R eds, Geriatrics. Blackwell, 1996

11. Anderson CA, Hughes RL: “Tremor.” In Mladenovic J ed. Primary Care Secrets. 2nd edition. Hanley

and Belfus, Philadelphia, 1998 Chapter 77

12. Ferguson MA, Hughes RL: “Muscle Weakness.” In Mladenovic J ed. Primary Care Secrets. 2nd edition.

Hanley and Belfus, Philadelphia, 1998 Chapter 78

13. Ferguson MA, Hughes RL: “Numbness and Tingling.” In Mladenovic J ed. Primary Care Secrets. 2nd

edition. Hanley and Belfus, Philadelphia, 1998 Chapter 79

14. Anderson CA, Hughes RL: “Cerebrovascular Disorders.” In Mladenovic J ed. Primary Care Secrets. 2nd



15. Distad DJ, Hughes RL: “Dizziness and Syncope.” In Mladenovic J ed. Primary Care Secrets. 2nd


16. Shrestha A, Hughes RL: “Seizure Disorders.” In Mladenovic J ed: Primary Care Secrets. 2nd edition.

Hanley and Belfus, Philadelphia, 1998 Chapter 83

17. Liang B, Hughes RL. “Clinical Science.” Hospital Practice Board Review Manual. 1998; 1:35-42

18. Anderson CA, Hughes RL: “Cerebrovascular Disease.” In Markovchick V ed. Emergency Medicine

Secrets. Hanley and Belfus, Philadelphia. 1998 Chapter 21

19. Hughes RL, Anderson CA, Sung GA: “Diagnostic Evaluation and Medical Management of Patients

with Ischemic Cerebrovascular Disease.” In Rutherford RB, ed. Vascular Surgery. 5th edition. Sanders,

Philadelphia, 1999 Chapter 128

20. Hughes RL, Earnest MP, “Transient Ischemic Attacks and Cerebrovascular Accident.” In Markovchick

VJ, Pons PT Emergency Medicine Secrets. 2002

21. FMD, Wilson J, Hughes RL: “Fibromuscular dysplasia.” eMedicine Journal, October 10, 2003

22. Hughes RL, C. Alan Anderson, “Tremor. Common Disorders of the Nervous System.” Primary Care

Secret. 3rd edition. Jeanette Mladnovic, MD 2004

23. Hughes RL, Michele A. Ferguson, “Muscle Weakness. Common Disorders of the Nervous System.”

Primary Care Secrets. 3rd edition. Jeanette Mladenovic, MD 2004

24. Hughes RL, Ferguson, MA, “Numbness and Tingling. Common Disorders of the Nervous System.”


25. Hughes RL, C. Alan Anderson, “Cerebrovascular Disorders. Common Disorders of the Nervous

System.” Primary Care Secrets. 3rd edition. Jeanette Mladenovic, MD 2004

26. Hughes RL, Jane Distad, “Dizziness and Syncope. Common Disorders of the Nervous System.”


27. Hughes RL, Achana Ahrestha, “Seizure Disorders. Common Disorders of the Nervous System.”

Primary Care Secrets. 3rd edition. Jeanette Mladneovic, MD 2004

28. Maa EA, Hughes RL. “Seizures in the ICU.” In: Albet RK, Ranieri M, Slutsky A, Takkala T, Torres T.

Clinical Critical Care Medicine. Mosby, Philadelphia. 2006 415-430

29. Hughes RL, Earnest MP, “Transient Ischemic Attacks and Cerebrovascular Accident.” In Markovchick

VJ, Pons PT Emergency Medicine Secrets. 2006

30. Wilson J, Hughes RL: “Fibromuscular dysplasia.” eMedicine Journal. Updated 2010

LETTERS, ABSTRACTS, AND OTHER PUBLICATIONS:

1. “The Magic Ninth,” A short story in The Alpha Centuri Communicator, 1977

2. Hughes RL: Letter to the Editor. NEJM 315:522, 1986


3. Hughes RL, Yonas H, Gur D, Latchaw R: Stable Xenon Enhanced CT in the First Eight Hours of

Cerebral Infarction. Stroke 1987; 18:283. (Abstract)

4. Yonas H, Hughes, RL, Hirsch WL, Latchaw RE, Gur D: Stable Xenon Enhanced CT Within the First

Eight Hours of Cerebral Infarction. Rad 1987; 165(P) Suppl: 40. (Abstract)

5. Hughes RL, Kaehny W, Earnest MP, Gabow PA: Intracranial Aneurysms in Autosomal Dominant

Polycystic Kidney Disease Show Familiar Clustering. Neurol 1988; 38 (Supp 1):131-2. (Abstract)

6. Hughes RL: Bluth EI: Relationship between carotid plaque hematoma and ischemic cerebrovascular

symptoms. Stroke 1988; 19:534. (Letter)

7. Bluth EI, Hughes RL: Importance of carotid artery plaque distribution and hemorrhage. Arch Neurol

1988; 45:602. (Letter)

8. Hughes RL: Ochsner JL: Preventing and Treating Stroke. Executive Health, fall 1989

9. Hughes RL: Cyclosporine related central nervous system toxicity in cardiac transplantation. NEJM

1990; 323:420-421

10. Hughes RL: Successful treatment of chronic misery perfusion with acetazolamide: report of six cases.

Neurology 1991; 41 (Suppl. 1):402. (Abstract)

11. Hughes, RL: NEJM 325:664, 1991. (Letter)

12. Hughes RL: Technetium 99 HMPAO Spect During an Episode of Transient Global Amnesia-A Case

Report. Stroke 1992; 23:463. (Abstract)

13. Ahmed L, Kramer A, Eckhoff D, Hughes RL, Eilertson T, Wallace H: Placement factors for elderly

stroke and hip fracture patients in acute rehabilitation or skilled nursing facility. J Am Geriatr Soc.

(Abstract)

14. Hughes, RL, Chapman A, Rubinstein D, et al: Recurrent Intracranial Aneurysms (ICA) in Autosomal

Dominant Polycystic Kidney Disease (ADPKD). Stroke 1996; 27:178. (Abstract)

15. Hughes RL, Corbey J, Liang B, Tyler B, and Ringel S: Residency restructuring for future resident

education: making difficult choices at the University of Colorado. Neurology 1997 48:A71

16. Hughes RL, Anderson CA, Kumpe D, Coldwell D: Selection of patients for intra-arterial CNS

procedures in the era of intravenous TPA. J of Stroke and Cerebrovascular Disease 1997, 6:472

17. Hughes RL, Smith D, Smith R, Lowther M: Creation of a regional organization to support stroke

resuscitation: The Colorado Acute Stroke Network (CASN). J of Stroke and Cerebrovascular Disease

1997, 6:471

18. Hughes RL, Grigsby J, Ahmed LA, Eilertson TB, Kramer AM: ADL Outcome of cortical stroke at one

year based on acute images. Stroke 1998; 29:317

19. Anderson A, Smith DB, Hughes RL: The Colorado Acute Stroke Network experience with intravenous

r-TPA in acute ischemic stroke. Neurology 1998; 50:A157


20. Torner JC, Wiebers DO, Brown RD, Whisnant JP: Factors Related to Location of Unruptured Cerebral

Aneurysms: Report of the International Study of Unruptured Intracranial Aneurysms (ISUIA)

Investigators. Stroke 1999; 30: 270. (Hughes RL, Denver, CO)

21. Clark WM, Albers GW, for the Atlantis Stroke Study Investigators: The Atlantis rt-PA (Alterplase)

Acute Stroke Trial: Final Results. Stroke 1999; 30: 234. (Hughes RL, Denver, CO)

22. Baker WH, Howard VJ, Howard G, Toole JF, for the ACAS Investigators: The Effect of Contralateral

Occlusion on Peri-operative and Late Stroke Rates in the Asymptomatic Carotid Atherosclerosis Study

(ACAS). Stroke 1999; 30: 242. (Hughes RL, Denver, CO)

23. Malinow MR, Chambless LE, Howard VJ, Toole JF, for the VISP Investigators: Screening of Plasma

Homocyst(e)ine Levels in Stroke Patients for the Vitamin Intervention for Stroke Prevention (VISP)

Clinical Trial. Stroke 1999; 30: 258. (Hughes RL, Denver, CO)

24. ISUIA Investigators, Mayo Clinic, Rochester, MN: Determinants of Intervention for Unruptured

Aneurysms Less than 10 MM in Diameter. Stroke 2000; 31:289

25. Grotta JC, Combination Therapy Stroke Trial: rt-PA +/-Lubeluzole Univ of Texas Medical School,

Houston, TX. Stroke 2000; 31:278 (Hughes RL, Denver, CO)

26. Sweeney C, Pelak V, Bennett J, Hughes RL: Delayed Onset of Optic Nerve Injury Following Cisplatin.

J of Neuro-Ophth 2000

27. Hughes RL, Frey LC: Magnesium Induced Hemorrhage after Successful Resuscitation of Stroke with IV

rTPA. World Stroke Congress. Melbourne, Australia. November 2000

28. Mueller DA, Anderson CA, Hughes RL, Newcombe J: Foreign Accent Syndrome Following a Stroke in

the Corpus Callosum. ANPA, San Diego. J Neuropsychiatry Clin Neurosci 14:1, 2002

29. Hughes RL: Aneurysms in Polycystic Kidney Disease. Neurosurgery in the Rockies, Vail CO, March

2002

30. Hughes RL: Successful Passage of Stroke Legislation in Colorado, USA. Stroke Society of Australia. Queensland, Australia. Sept 2-5, 2002

31. Hughes RL: Successful Passage of Stroke Legislation in Colorado. Western States Stroke Consortium.

Los Angeles, September 2002

32. Torner JC, Weiber DO, Piepgras D, Brown RD, and the ISUIA Investigators: Perioperative Cerebral

Infarction and Hemorrhage in Surgical Treatment of Unruptured Intracranial Aneurysms. Stroke 2003

34:246

33. Hughes RL: Rescreening of ADPKD Patients with initial negative screening. Neurosurgery in the Rockies, Vail, CO. March 2004

34. Hughes RL, The ASA/JCAHO Stroke Center certification initiative. Neurosurgery in the Rockies, Vail, CO March 2004

35. Hughes RL: Hypothermia in Ischemic Stroke. Neurosurgery in the Rockies, Vail, CO. February 2005

36. Hughes RL: Comprehensive Stroke Center Certification. Neurosurgery in the Rockies, Vail, CO


2006

37. Hughes RL: Stroke Center certification in the USA. Australasia Stroke Society, Adelaide, Australia 2006

38. Hughes RL: Neurosurgery in the Rockies; Emerging use of statins in cerebrovascular disease. Vail, CO 2007

39. Hughes RL: Comprehensive Stroke Update. Neurosurgery in the Rockies. Beaver Creek, CO 2010

40. Hughes RL: Comprehensive Stroke Certification. Western States Stroke, Albuquerque, NM September 2010

41. Smith, DB, Hughes RL: Inter-hospital Transfers in the Colorado Stroke System. ISC Feb 2012

42. Hughes RL: The Call Fleming Syndrome. Neurosurgery in the Rockies, Beaver Creek, CO Feb 2012

43. Hughes RL: Carotid Artery Disease, Family Medicine Board review, July 2012

44. Hughes RL: Comprehensive Stroke. Western States Stroke Consortium, Scottsdale, AZ September 2012

45. Hughes RL: Nagal M: Herpes Simplex Virus Infection in the Acute Presentation of Fibromuscular

Dysplasia. WSOC, Hyderabad, India. October 2016

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