university of connecticut biomedical engineering … program overview.pdfuniversity of connecticut...

University of Connecticut Biomedical Engineering Program

DIRECTORS Rajeev Bansal, BME Program Director

Donald Peterson, UG Program Director Quing Zhu, GRAD Program Director

STAFF Jennifer Desrosiers, Program Assistant II

Lisa Ephraim, Academic Advisor I

1 http://www.bme.uconn.edu

University of Connecticut Biomedical Engineering Educational Program


MISSION STATEMENT The Biomedical Engineering Program seeks to provide students with the fundamental knowledge and skills needed to excel in the integration of science, engineering, and medicine to improve the quality of life and to become leaders in biomedical engineering.


Undergraduate Program Overview

2011-2012

• Incoming Freshmen Fall 2011 (10 Day census) = 68 • Total Number of Students (10 Day census) = 319 • 67% Male, 33% Female • Number of Honors Students = 83 (26%) • Graduates = 73 • 22% Pre-Medical • Number of Study Abroad Students = 6 • 14 Office of Undergraduate Research Awards for 2011-2012


Undergraduate Program • Four Tracks

• Biomechanics/Bioinformatics/Biosystems, Imaging, & Instrumentation/Biomaterials

• State of the Art Laboratories • Pre-Medical/Pre-Dental Curriculum • Study Abroad Opportunities in 13 Locations • Dual Degree in BME & Foreign Language

• French, German, Italian, & Spanish

• Five-year BS/MS Academic Plan • ABET Accredited from 2005 to Present • Active Student Organizations

• BMES, AEMB Honor Society, Global Medical Brigades

• Deligeorges Family Scholarship in Biomedical Engineering (awarded annually) • Exciting Undergraduate Research opportunities

5

Undergraduate Research 2012 Frontiers in Undergraduate Research Poster Exhibition: Presenters & Advisors

Temporal Nonlinearities for Amplitude Modulation Coding in the Unanesthetized Rabbit Inferior Colliculus, Peter Boutros Advisor: Monty Escabí, Associate Professor, Biomedical Engineering Mechanical Properties of Chordae Tendineae in Human & Animal Models, Kaitlyn Clarke et al Advisor: Wei Sun, Assistant Professor, Mechanical Engineering Biomechanical Analysis of Healthy & Abnormal Aortic Tissue, Stephany Santos Advisor: Wei Sun, Professor, Biomedical Engineering Determination of Radial Force & Coefficient of Friction with a Self-Expanding Transcatheter Aortic Valve Stent, Andrew Reynolds et al Advisor: Wei Sun, Professor, Mechanical Engineering A Methodology of Measuring Coronary Flow in a Porcine Aortic Root Using a Pulsatile Flow Loop, Joseph Calderan et al Advisor: Wei Sun, Assistant Professor, Mechanical Engineering

(http://www.our.uconn.edu; http://www.bme.uconn.edu/research-opportunities.php)

http://www.our.uconn.edu/

http://www.bme.uconn.edu/research-opportunities.php




Undergraduate Research (Cont.) 2012 Summer Undergraduate Research Fund (SURF) awards: Awardees & Advisors

Bacterial SmtA as an Antioxidant that Influences Bacterial Survival in a Mammalian Infection Neyati Patel Research Advisor: Michael Lynes, Molecular and Cell Biology Signal Detecting Theory for Detecting Sound Periodicity Cheng Yang Research Advisor: Heather Read, Psychology Enhancing Autistic Children's Communicative Skills Darryl Cummings Research Advisor: Anjana Bhat, Neag







Undergraduate Research (Cont.) 2012 OUR Travel to Present awards: Presenters & Advisors

Enhancing Autistic Children's Communicative Skills Andrew Reynolds Research Advisor: Wei Sun, Biomedical Engineering A Methodology of Measuring Coronary Flow in a Porcine Aortic Root Using aPulsatile Flow Loop Joseph Calderan Research Advisor: Wei Sun, Biomedical Engineering The Preparation of Silver-Based Nanomaterials Through Electrochemistry and Wet-Chemistry Honorio Valdes Espinosa de los Monteros Research Advisor Yu Lei, Chemical Engineering







Undergraduate Research (Cont.) 2012 OUR Travel to Conduct Research awards: Awardees & Advisors

Bone and Cartilage Regeneration via Bioactive Nanofibers Craig Hanna Research Advisor: Dr. Lakshmi Nair, Department of Orthopedic Surgery Temporal Nonlinearities for Amplitude Modulation Coding in the Unanesthesetized Rabbit Inferior Colliculus Peter Boutros Research Advisor: Monty Escabi, Electrical and Computer Engineering

2012 OUR Research Supply award: Awardee & Advisor

Opening New Avenues for Flow-Chemistry Using Wilkinson's Catalyst Christopher Lee Research Advisor, Nicholas Leadbeater, Chemistry







Graduate Program Overview

• Six Major Research & Education Areas • 61 Masters Students & 29 PhD Students • Nationally & Internationally Recognized Faculty Members • Collaborative Research Facilities in Storrs & UCHC


Graduate Program

Six Major Research & Education Areas: • Biomechanics • Bioinformatics • Biomaterials & Tissue Engineering • Physiological & Biomedical Modeling • Bio-Imaging & Instrumentation • Clinical Engineering


Clinical Engineering Internship Overview

• Frank Painter & John Enderle: Directors • 2-Year Masters Degree • Hospital Internships located in Connecticut, Massachusetts, & Rhode Island • Competitive admission: applicants from around the world! • Approximately 18 interns per year

http://www.bme.uconn.edu 12 12 http://www.bme.uconn.edu

Clinical Engineering Internship Program

Clinical engineering is the application of engineering methods and technology to the delivery of health care. The clinical engineer is a member of the health care team responsible for the management of medical technology in the hospital environment. The tasks that a clinical engineer provides include supervising a clinical engineering department, designing or modifying sophisticated medical instruments, evaluating new medical equipment for purchase, repairing equipment, testing the safety of equipment, asset management, vendor service management, projects (i.e., R&D, re-engineering, new system implementations), regulatory support (i.e., JCAHO [Joint Commission for the Accreditation of Healthcare Organizations], CAP [College of American Pathologists]), and instructing clinicians (nurses) in the proper use of medical equipment. Clinical engineering, therefore, involves the application of engineering techniques to health care delivery.


Faculty Overview 23 Core Faculty who may be engaged in:

Teaching BME courses (undergraduate/graduate) Advising students (undergraduate/graduate) Conducting collaborative research in BME Participating in BME service & outreach activities (open houses, curriculum development, graduate admission reviews, etc. )

29 Affiliated Faculty who may be engaged in: Teaching BME graduate courses Advising graduate students Conducting collaborative research in BME


Core Faculty Athanasios Bamis

(CSE) Krystyna Gielo-

Perczak (BME)

Liisa Kuhn (UCHC)

George Lykotrafitis (ME)

Donald Peterson (BME/UCHC)

Mei Wei (CMBE)

Jinbo Bi (CSE)

Bahram Javidi (ECE)

Sangamesh Kumbar (UCHC)

Ion Mandoiu (CSE)

Ranjan Srivastava (CMBE)

Chen Xu (ECE)

John Enderle (ECE)

Mohammad (Maifi) Khan

(CSE)

Cato Laurencin (UCHC)

Lakshmi Nair (UCHC)

Wei Sun (ME)

Quing Zhu (ECE)

Monty Escabi (ECE)

Yusuf Khan (UCHC)

Yu Lei (CMBE)

Syam Nukavarapu (UCHC)

Yong Wang (CMBE)


Affiliated Faculty Douglas Adams

(UCHC) A. Jon Goldberg

(UCHC)

Ulrike Klueh (UCHC)

Jay McIsaac (Pre-Med)

Frank Painter (Clin Engr)

Richard Simon (UCHC)

Leslie Bernstein (UCHC)

Greg Huber (UCHC)

Donald Kreutzer (UCHC)

William Mohler (UCHC)

Carol Pilbeam (UCHC)

David Waitzman (UCHC)

Anthony Brammer (UCHC)

Faquir Jain (ECE)

Jay Lieberman (UCHC)

Andrew Moiseff (PNB)

Heather Read (PSYC)

Nicholas Warren (UCHC)

Martin Cherniak (UCHC)

Kazem Kazerounian (SoE Dean)

Lanbo Liu (CEE)

Nejat Olgac (ME)

Mansoor Sarfarazi (UCHC)

Ji Yu (UCHC)

Pouran Faghri (Allied Health)

Duck Kim (UCHC)

Les Loew (UCHC)

Douglas Oliver (UCHC)

Dong-Guk Shin (CSE)

http://www.bme.uconn.edu 16

Collaborative BME Research in partnership with colleagues across the Storrs

and UCHC campuses

Bioinformatics Biomedical informatics Bio-imaging Biomaterials Biosensors Biomechanics

Metabolic Engineering Therapeutic Imaging Bio Systems Analysis MEMS Bio/nanodevices

A. Bioinformatics and Biomedical Informatics (9 faculty)

B. Genetic Bioengineering, Characterization & Nanosystems Analysis (16 faculty)

C. Therapeutic Imaging, Genetic MEMS and Nano-Bio Devices (3 faculty)

D. Other BME Faculty Research (12 faculty)

Significant applied research in:


A. Bioinformatics and Biomedical Informatics

• Reda A. Ammar, Professor and Department Head (CSE) with research foci of software performance engineering, parallel and distributed computing, and real-time systems.

• Athanasios Bamis, Assistant Professor, with research foci of sensor-based activity recognition, mining of spatio-temporal event patterns, and human-centric systems for proactive wellness applications.

• Jinbo Bi, Associate Professor (CSE), with research foci of machine learning and statistical data mining to solve real-world challenges on various biomedical informatics problems.

• Steven A. Demurjian, Professor (CSE) and Co-Director, Research Informatics, BMI Division, with research foci of collaborative security, ontologies, architectures, and systems.

• Maifi Hasan Khan, Assistant Professor (CSE), with research foci on reliability of large scale distributed systems, and preventative health care leveraging mining of historical data.

• Ion Mandoiu, Associate Professor (CSE and BME), with research focus in bioinformatics algorithms, computational genomics, and computational molecular epidemiology.

• Sanguthevar Rajasekaran, UTC Chair Professor (CSE), and Director of the Booth Engineering Center for Advanced Technologies (BECAT) with research foci algorithms for computational biology, and fundamental data structures needed in bioinformatics (including suffix arrays) all of which have relevance to personalized medicine.

• Dong-Guk Shin, Professor (CSE and BME), with research foci of analysis of ChIP-seq, RNA-seq, microRNA and microarray data, interoperability among public and private annotation databases, seamless research collaboration through HPC workflows, and image processing methods for bone histomorphometry.

• Yufeng Wu, Assistant Professor (CSE), with research foci of algorithms for computational biology problems in genetics, evolution and high-throughput sequencing.

http://www.bme.uconn.edu 18 http://www.bme.uconn.edu 18

Athanasios (Nasos) Bamis

Human Sensing Behavior Analysis

47.2 in. x 31.5 in.

Glass Room

Dinning Room

Sitting Room

70.9 in. x 31.5 in.

Bedroom

Kitchen

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Eldercare & Wellness Technologies


• Laboratory Personnel – 3 PhD students

• Research Interests – Real-time Health Monitoring and Preventative

Healthcare – Cloud Based Storage Service for Streaming Data – Reliability and Troubleshooting Edge Clients – Software Architecture for Self-powered Devices


Mohammad “Maifi” Hasan Khan


Ion Mandoiu - 1 of 2 Research Areas: • Bioinformatics Algorithms

• Computational Genomics and Systems Biology

• Computational Methods for Next-Generation Sequencing

• Immunoinformatics

Sources of Funding: • NSF, USDA, Life Technologies Inc.

Lab website: • http://dna.engr.uconn.edu

http://dna.engr.uconn.edu/


• Contagious avian bronchial virus that costs U.S. poultry farmers millions of dollars each year in lost revenue

• Partners: – Dr. Mazhar I. Khan of Pathobiology

& Veterinary Medicine

– Dr. Rachel O’Neill of Molecular & Cell Biology

– Dr. Alex Zelikovsky of Georgia State University

• Funded by USDA’s National Institute of Food & Agriculture

Ion Mandoiu - 2 of 2 Associate Professor (CSE, BME)


Dong-Guk Shin-I of 2 Professor (CSE, BME)

• Interoperability among public and private annotation databases

• Image processing methods for bone histomorphometry

• Partners: – David Rowe, M.D (UCHC)

– Cato Laurencin, M.D (UCHC)

– Alexander Lichtler (UConn-Storrs)

– David Goldhamer (UConn-Storrs)

• Project: Bone regrowth in mice as a crucial step toward stimulating human bone regeneration. Funded ($2.7M) by DOD.


2 of 2 - Dong-Guk Shin & Seung-Hyun Hong

a b a b

Mouse 3 female

Mouse 4 male

Assess different strategies of progenitor cells, scaffolds and host preparation to heal critical defects:

Identify whether scaffold X with progenitor cell Y best heals the skeletal damage.

Can the assessment be done objectively without biases?

Use of image processing technique with a centralized database can.

Ultimately, provide the most consistent preclinical data for approval for clinical trials.


B. Genetic Bioengineering, Characterization & Nanosystems Analysis

• W.K. Anson Ma, Assistant Professor (CMBE), with research focus on understanding the fate of drug nanocarriers in macro- and microcirculation, through rheo-optical experiments and modeling.

• C. Barry Carter, Professor and Department Head (CMBE), and President of the International Federation of Societies for Microscopy with research focused on the applications of microscopy to materials, including soft materials, biomaterials and the interface between biomaterials and materials inserted into the body, all of which are critical for improving implants and other medical devices for personalized medicine.

• Tai-Hsi Fan, Associate Professor (ME), with research focus on basic properties of complex fluids and biological soft matters, and small scale transport phenomena of chemical processes

• Pu-Xian Gao, Assistant Professor (CMBE), with research foci on hierarchical nanomaterials for biomedical applications, which have relevance to personalized nanomedicine.

• Bryan D. Huey, Associate Professor (CMBE), relevant research in nanoscale sensors, cellular mechanics, and high resolution imaging, including: (i) the influence of genetic manipulation on cell morphology, stiffness, response to various substrates, etc.; and (ii) high resolution imaging of chromosomes.

• Horea Ilies, Associate Professor (ME), with research foci in protein folding and docking, including haptic interfaces for interactive protein manipulation; geometric computing and algorithms; and virtual reality and visualization.



• Kazem Kazerounian, Professor (ME and BME) and Associate Dean of Research & Strategic Initiatives, with expertise spanning computational methods in engineering and mechanical design, protein folding, bio-mechanics and nano-bio-machines.

• Yu Lei, Associate Professor (CMBE and BME), with research concentrating on the development of various (bio)(nano)sensors, which can be used for biomedical applications, ranging from the diagnosis of disease to new drug discovery. New tools such as fast and cost-effectively decoding human genome diagnostics and biomedical devices for high throughput screening of drug effects are among the key factors that will enable the success of personalized medicine in our healthcare system.

• George Lykotrafitis, Assistant Professor (ME and BME), with research interests in hereditary blood diseases including sickle cell disease.

• Mu-Ping Nieh, Associate Professor (CMBE), with research interests in formulation of lipid-based targeting therapeutic/diagnostic nanocarriers by self-assembling mechanism, which can be applied to large-scale production, and fundamental understanding of interaction between proteins and lipids.

• Nejat Olgac, Professor (ME and BME), with expertise in dynamic systems and control specialty, micro-device development and control; and biological cell manipulations, especially ICSI (intra-cytoplasmic sperm injection) technology development.



• Rampi Ramprasad, Associate Professor (CMBE), with foci in (i) materials informatics to design and discover new materials, systems and processes with a desired set of properties, through systematic exploration of the periodic table; (ii) materials research using accurate and predictive quantum mechanical computations; and (iii) systems being studied include organic and inorganic materials, interfaces between dissimilar materials, and materials at various levels of dimensionality (quantum dots, quantum rods, superlattices, amorphous, and bulk crystalline systems).

• Wei Sun, Assistant Professor (ME and BME) with research foci on cardiovascular biomechanics, computational mechanics, and personalized medical treatment.

• Brian Willis & Ranjan Srivastava, Associate Professors (CMBE), whose research collaborations include explorations of novel DNA sequencing methods for personalized medicine

• Yong Wang, Associate Professor (CMBE and BME), with expertise involving the development of biomolecular engineering tools to elucidate genetic mechanisms and pathways relevant to diseases, and to create artificial molecular loops to intervene natural pathways for the treatment of human diseases.

• Mei Wei, Associate Professor (CMBE and BME), with research focus on fabrication of biomaterials (surface treatment, biomimetic coatings, novel tissue engineering scaffold fabrication, ceramic/polymer composite processing), in vitro and in vivo cell-biomaterial interactions, drug delivery, and establishment of 4D imaging platforms for in situ visualization of cell-cell, cell-scaffold interactions in a living animal.

http://www.bme.uconn.edu 27 27

Yu Lei – I of 2 Research Areas:

• Bionanotechnology in chemical sensing and biosensing of biologically meaningful small molecules

• Microfluidic sensing technology for pathogen detection

• Non-enzymatic glucose sensing for in vitro and in vivo application

• Non-invasive technology for lung cancer pre-screening

Sources of funding: NSF, DOD, DHS, USGS


Yu Lei – 2 of 2 Associate Professor (CMBE, BME)

• Development of various (bio)(nano)sensors for biomedical applications, ranging from the diagnosis of disease to new drug discovery.

• Sample Project: Develop a superior device for the detection of pathogenic bacteria in food. (Funded by NSF.)

• Partners: – Dr. Kumar Venkitanarayanan (UConn

Department of Animal Science)

– Dr. Hongwei Sun (UMass-Lowell)


George Lykotrafitis - I of 3 Research Areas: • Atomic force microscopy and modeling in Sickle Cell Disease

• Cytoadhesion

• Force nanoscopy in living neurons

• Large scale molecular dynamics simulation of cellular membranes and filaments

• Agent-based modeling

Sources of funding: NSF, Am. Heart Assoc.


Molecular Experiments and Modeling in Sickle Cell Disease

Atomic force microscopy on

erythrocytes from patients

with sickle cell disease

Hemoglobin S fiber model

Increased adhesion

receptor expression

Collaborator: B. Andemariam, M.D., UCHC

Funding: NSF, Am. Heart Assoc.

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Normal

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SCD

De-oxygenated SCD

Stiffness (kPa)

Red Blood Cell

Membrane model

George Lykotrafitis - 2 of 3


George Lykotrafitis - 3 of 3 Assistant Professor (ME, BME)

• Research in hereditary blood diseases including sickle cell disease.

• Project: Computational models and experiments at the cellular level to study sickle cell disease, a hereditary blood disorder caused by a one point mutation in the gene that encodes adult hemoglobin.

http://biophysicalsociety.files.wordpress.com/2011/12/206276-102-1-cover-art.jpg


Nejat Olgac Professor (ME, BME)

• Dynamic systems and control, micro-device development, MEMS

• Sample project: ICSI (intra-cytoplasmic sperm injection) technology (NSF, NIH)

• ICSI experiments are conducted at University of California - Davis, Harvard Medical School and University of Connecticut.


Ranjan Srivastava - Systems Biology, Metabolic Engineering, & Machine Learning

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Research Thrusts

• Mathematical Modeling of Infectious Diseases (HIV, anthrax)

• Therapeutic Treatment Optimization

• Genome-scale Metabolic Modeling

• Microbiome Computational Biology & Bioinformatics


Wei Sun: Cardiovascular Biomechanics

Research focus: Experimental study and constitutive modeling of cardiovascular tissues Computational study of heart valve biomechanics Transcatheter medical device design

2 Postdoc fellows, 7 PhD students, 1 Masters students Major awards received for this research • NIH R01 and R21 grants • American Heart Association SDG grant • CT DPH Biomedical Research Grant

Tissue Mechanics Laboratory

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Yong Wang - I of 2: Biomolecular & Biomimetic Engineering


Yong Wang - 2 of 2 Associate Professor (CMBE, BME)

• Biomolecular engineering tools to elucidate genetic mechanisms for treatment of human diseases.

• 3 NSF grants on biomolecular recognition, which enables and regulates diverse functions within and among cells.

• Novel synthetic substances that can recognize a broad range of targets, including small molecules, large biomolecules, and even whole organisms.

http://news.engr.uconn.edu/engineeringnewfaculty.php/yongwang2a


Mei Wei 1 of 2 – Biomaterials Laboratory Research Projects:

• Fabrication of novel tissue engineering scaffolds for bone and osteochondral repair

• Biomimetic apatite and apatite/collagen coatings for bone repair and drug delivery

• Establishment of in vivo time-lapsed imaging platform for in situ visualization of cell-scaffold interplay during new bone formation and remodeling

• Dense apatite-polymer fiber absorbable composites for medium- and high-load bearing skeletal repair applications

Funding: NIH, NSF, Department of Education


Mei Wei - 2 of 2 Associate Professor (CMBE, BME)

• Biomaterial, tissue engineering scaffold fabrication, in vitro and in vivo cell-biomaterial interactions, drug delivery, and establishment of 4D imaging platforms for in situ visualization of cell-cell, cell-scaffold interactions in a living animal.

• Sample Project: Develop a scaffold that can mimic human tissue and encourage cartilage regeneration around joints (NSF, NIH).

• Partner: David Rowe, M.D.


C. Therapeutic Imaging, Genetic MEMS

and Nano-Bio Devices

• Monty A. Escabí, Associate Professor (ECE and BME), with research interests in the study of brain mechanisms in the auditory midbrain and cortex for hearing perception. With Dr. H.L. Read, his long term focus is on developing clinical strategies and brain implants for treating deafness and hearing deficits such as for developmental language impairments.

• Ali Gokirmak, Assistant Professor (ECE), whose research includes semiconductor devices and nano-science/nano-technology. Experimental and computational work on nano and micro-scale electronic devices and systems integrates nano and micro-fluidics with electronics. This team has attempted to fabricate a nano-scale transistor based DNA / protein sequencer using CMOS fabrication techniques and also has expertise in electrical characterization and instrumentation.

• Quing Zhu, Professor (ECE and BME), whose expertise spans novel sensing and imaging techniques to enhance cancer diagnosis, monitoring and characterization. She has collaborated for years on imaging research with colleagues at the UCHC, Hartford Hospital and other medical facilities to test the efficacy of her imaging devices.


PI: Monty A. Escabi

Funding: National Institutes of Deafness and

Communication Disorders (NIH)

Collaborators: Psychology Dept., UConn Health Center

Univ. Pennsylvania Medical School

Sound processing in the brain

- How do single neurons and networks of

neurons encode biologically relevant sounds (e.g.,

speech, animal communications sounds, music)?

- Strategies and Experiments: Record brain activity from

mammals to understand how single brain cells and

groups of neurons encode sounds.

- Nonlinear input-output models of the signal

processing performed by single neurons.

- Physiologically plausible network models of central

auditory structures in the brain

Monty A. Escabi - I of 2


Monty A. Escabi - 2 of 2 Associate Professor (ECE, BME)

• Brain mechanisms in the auditory midbrain and cortex for hearing perception.

– Single neuron and cellular network level

• Partner: – Dr. Heather Read

• Sample project: Clinical strategies and brain implants for treating deafness and hearing deficits (funded by NIH/NIDOD/NSF).


Near Infrared Light and Ultrasound Imaging and Devices for Early Breast Cancer Diagnosis and for Predicting Neoadjuvant Chemotherapy Response Photoacoustic Imaging for Ovary Cancer Diagnosis Funding from NIH, DOD, Donaghue Foundation, and Connecticut Public Health

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Quing Zhu - I of 2


Quing Zhu - 2 of 2 Professor (ECE, BME)

• Novel sensing and imaging techniques to enhance cancer diagnosis, monitoring and characterization.

• Partners:

– Molly Brewer, DVM, MD

– Colleagues at the UCHC, Hartford Hospital and other medical facilities for clinical studies.

• Sample Project: ultrasound-guided near infrared technique to assess the chemotherapy response of individual breast cancer and ovarian cancer patients, and to predict treatment outcomes before the initiation and at early cycles of chemotherapy. (Funded by NIH, Donaghue Foundation 5-year Investigator Award (totaling $3M).)


D. Other BME Faculty Research

• John D. Enderle, Professor (ECE and BME), with research interests in the continued development of an integrated head and eye movement model driven by visual, auditory and vestibular stimuli with applications to the detection and location of traumatic brain injury.

• Krystyna Gielo-Perczak, Assistant Professor in Residence (BME), with research interests in musculoskeletal biomechanics & joint injuries, anticipatory medical devices, human balance control, human-centered design & engineering, and prosthetics & orthotics.

• A. Jon Goldberg, Professor (UCHC), with research interests in novel materials for dental applications, and biomaterials design to influence cell behavior (with Drs. Kuhn, Rowe, Mina, Ksai).

• Faquir Jain, Professor (ECE), with a research focus on the development of an implantable wireless glucose sensor(with IMS and Pharmacy).

• Bahram Javidi, Board of Trustees Distinguished Professor (ECE), with research interests in real time non invasive 3D imaging and visualization of cells.

• Yusuf Khan, Assistant Professor (UCHC), with a research focus on using clinically prescribed low intensity pulsed ultrasound to apply transdermal physical forces to implanted cell-scaffold constructs as a mechanical stimulus for accelerated bone defect repair.


D. Other BME Faculty Research (Cont.)

• Sangamesh Kumbar, Assistant Professor (UCHC), with research interests in the developement and characterization of novel biomaterials and scaffolds for drug delivery and regenerative engineering applications.

• Cato Laurencin, Chief Executive Officer of the Connecticut Institute for Clinical and Translational Science, Director of the Institute for Regenerative Engineering and the Van Dusen Endowed Chair in Orthopaedic Surgery. Clinical Research: Regeneration of knee tissue; Musculoskeletal regeneration. Basic Science Research: Tissue engineering.

• Lakshmi Nair, Assistant Professor (UCHC), with research interests in cell instructive microenvironment to promote tissue regeneration.

• Syam Nukavarapu, Assistant Professor (UCHC), with research interests in tissue engineering and bone regeneration for orthopedic applications.

• Donald Peterson, BME UG Program Director, with research interests in investigating the dynamics of human performance and exposure and response through comprehensive field and laboratory studies.

• Rajeev Bansal, Professor and Head (ECE)/BME Interim Program Director, with research interests in the biological effects and medical applications of Microwaves and RF.


John Enderle The long term objective of this research is the continued development of an integrated head and eye movement model driven by visual, auditory and vestibular stimuli. Based on our research, a low-cost, portable device to detect and locate traumatic brain injury is being developed.

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The specific objectives of this research are to investigate and to ultimately produce a model that will predict the head and eye movement responses to any combination of visual, auditory, and vestibular inputs in a changing environment. Since the models developed are driven by subsystems, modeled mathematically and parameterized by experimental data, one can observe phenomenon down to the cell level, as well as the system level, to observe performance. The linear muscle fiber model developed by Enderle and coworkers is the first model to have the static and dynamic characteristics of muscle.

http://www.bme.uconn.edu

Krystyna Gielo-Perczak Biomedical Engineering: *methodologies/experiments

for validation and analysis of human joint strength

Musculoskeletal Biomechanics & Joint Injuries

• Personalized Approach to Shoulder/ Glenohumeral Joint

• Human Body Modeling and Simulation

Prosthetics & Orthotics

Anticipatory Medical Devices; Human Balance Control

Multidisciplinary Medical Devices Design requiring the broad *communications among disciplines (MRI technique, biomechanics, rehabilitation, analytical modeling, human centered engineering design)

Human Centered Design & Engineering

Technology

47


A. Jon Goldberg Novel Materials for Dental Applications

Beta-Titanium alloys (funded, patented, commercialized) Fiber-reinforced composites (funded, patented, commercialized) Biocatalyzed Mineralization (funded, patents pending) Polyphenylene polymers (funded, patented, licensed)

Biomaterials Design to Influence Cell Behavior (with Drs. Kuhn, Rowe, Mina, Ksai)

Lineage-specific fluorescent proteins to quantify biomaterial effects Scaffolds to influence dentin (tooth) regeneration


Faquir Jain: Implantable Biosensors Project @ UCONN

Development of the

sensor with

enhanced linearity

and longer life times

(IMS)

Development of

wireless sensor,

Electronic Processor,

Power & Comm.

(ECE)

Design of novel

coatings to minimize

negative tissue

responses, improve

bio-compatibility

(Pharmacy)

Miniaturized 18 guage needle implantation

Longer lifetimes and no inflammation,

Glucose, pH, Oxygen & Lactate Detection

Self calibration &User-independent operation.


Real time non invasive 3D imaging and visualization of cells Cell identification and classification using 3D optical imaging

3D optical imaging with micro fluidic devices provides: Real-time cell morphology. Source – low power Laser. Detector – CCD/CMOS

Example: RBC imaged with 3D holographic microscopy.

Directly provides cell thickness, volume, 3D profile.

Bahram Javidi Board of Trustees Distinguished Professor Electrical and Computer Engineering [email protected]

Major Awards: Guggenheim Fellowship


• Appointments/Affiliations – Dept. of Orthopaedic Surgery

– Institute for Regenerative Engineering

– Biomedical Engineering Program

– Chem. Mater. Biomolec Eng.

• Research Areas – Large scale bone defect repair strategies

• Ultrasound

• Functionalized allografts

– Bone Tissue Engineering

– Polymer/ceramic composites

• Personnel – 2 graduate students

• Biomedical Engineering Program

• CMBE

• Teaching – Director, BME Biomaterials course http://www.bme.uconn.edu

51

Yusuf Khan

Functionalizing devitalized allografts by incorporating a thin polymeric coating (left) that functions as a delivery vehicle for potent

osteoinductive growth factors to enhance large defect bone repair (right)

pre - LIPUS In situ LIPUS (ultrasound pulsing) Recovery (post LIPUS)

10

µm

Using clinically prescribed low intensity pulsed ultrasound to apply transdermal physical forces to implanted cell-scaffold constructs as a

mechanical stimulus for accelerated bone defect repair


Sangamesh Kumbar

Research Area Development and characterization of novel biomaterials and

scaffolds for drug delivery and Regenerative Engineering applications


Institute for

Regenerative Engineering

• Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences

• Director, Dr. Cato T. Laurencin • Other Core Team Faculty:

Dr. Yusuf M. Khan Dr. Lakshmi S. Nair Dr. Sangamesh G. Kumbar Dr. Syam P. Nukavarapu Dr. Kevin Lo Dr. A. Jon Goldberg

• Total graduate students,

fellows, and residents: 40


Lakshmi S. Nair : Cell Instructive Microenvironment To Promote Tissue Regeneration

Laboratory Personnel

1 Post Doctoral Fellow, 2 PhD (1 defended), 1 MS, and 5 UG students, 1 Medical student, 2 High School students

Areas of Research Interest

Injectable biomaterials for minimally invasive procedures

Biomaterial ligands for receptor mediated cell signaling

Nanostructured materials for tissue regeneration

Major Sources of Funding

Federal Agencies : Department of Defense (Army), National Institutes for Health, National Science Foundation

State Agencies: Connecticut Stem Cell Institute, CSTC

Courses Taught

Co-developed & Co-teach “Biomaterials” undergrad course

Co-teach MD 5418, MD6445

Cells encapsulated in injectable gels


Syam Nukavarapu Orthopedic Surgery

Chemical, Materials & Biomolecular Eng.

Biomedical Engineering

Oxygen Tension Controlled Matrices for Large-Area Bone Regeneration

Blood Derived Endothelial Progenitor Cells for Vascularization

Research Areas: Bone and Osteochondral Tissue

Engineering

Optimal Matrices and Effective

Progenitors

Clinically Relevant Tissue

Engineering Methods

Personnel:

2 PhD, 1 MS, and 1 UG students

1 Dental, and 1 Medical Student


BIODYNAMICS

Investigating the dynamics of human performance and exposure and response through comprehensive field and laboratory studies

DONALD R. PETERSON Director

([email protected])

Computational Biodynamics


Rajeev Bansal: Applied Electromagnetics

Interaction of EM waves with Dielectric targets with applications to:

• Antennas near sea-water (submarines) 4 doctoral dissertations

• Electromagnetic diagnostics of power cables 2 patents: technology licensed to IMCORP

• Biological effects /medical applications COMAR: IEEE Committee on Man and Radiation

Columnist for:

IEEE Microwave Magazine

IEEE Antennas and Propagation Magazine


Contact Information

Rajeev Bansal BME Program Director ITE Building, Room 463 860-486-3410 or 2878 [email protected]

Jennifer Desrosiers BME Program Assistant II Bronwell, Room 217 860-486-0116 [email protected]

Donald Peterson BME Undergraduate Program Director Bronwell, Room 217 860-486-0372 [email protected]

Lisa Ephraim BME Academic Advisor I Bronwell, Room 217 860-486-0163 [email protected]

Quing Zhu BME Graduate Program Director ITE Building, Room 337 860-486-5523 [email protected]

Address Biomedical Engineering Program 260 Glenbrook Rd, Unit 3247 Storrs, Connecticut 06269-3247 Ph: 860-486-5838, Fax: 860-486-2500

university of connecticut biomedical engineering … program overview.pdfuniversity of connecticut...

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