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University of Groningen
A tubulo-centric view on cardiorenal diseaseSinkeler, Steef Jasper
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Publication date:2016
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Citation for published version (APA):Sinkeler, S. J. (2016). A tubulo-centric view on cardiorenal disease.
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A tubulo-centric view on cardiorenal disease
Publication of this thesis was made possible by donations from the Graduate School
of Medical Sciences, the Groningen University Institution on Drug Exploration, the
Rijksuniversiteit Groningen and the University Medical Center Groningen.
ISBN: 978-94-6233-307-9
Cover design: Matthijs Kuiper
Layout: Gildeprint, Enschede
© 2016 S.J. Sinkeler.
All rights reserved. No parts of this publication may be reported or transmitted, in any
form or by any means, without prior permission by the author.
A tubulo-centric view on cardiorenal disease
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
29 juni 2016 om 16.15 uur
door
Steef Jasper Sinkeler geboren op 16 september 1985
te Nijmegen
Promotores: Prof. dr. G.J. Navis
Prof. dr. S.J.L. Bakker
Beoordelingscommissie: Mw. Prof. dr. M.C. Verhaar
Prof. dr. B. Meijers
Prof. dr. D.J. van Veldhuisen
Paranimfen
Mw. Dr. E. van den Berg
Mw. Drs. F.S. Sinkeler
Table of contents
1. Introduction and outline 9
2. Validation of prediction equations for 24-hour urine creatinine excretion rate
in the general population and development of a new equation: the LifeLines study 23
3. Creatinine excretion rate and mortality in type II diabetes and nephropathy 45
Diabetes Care. 2013 Jun;36(6):1489-94
4. Higher body mass index is associated with higher fractional creatinine
excretion in healthy subjects 61
Nephrol Dial Transplant. 2011 Oct;26(10):3181-8
5. Higher fractional excretion of creatinine is associated with lower risk of
cardiovascular events and all-cause mortality in renal transplant recipients 83
6. Association of extracellular volume with long-term risk for cardiovascular
events in renal transplant recipients 101
7. A re-appraisal of volume status and renal function impairment in chronic
heart failure: combined effects of pre-renal failure and venous congestion
on renal function 119
Heart Fail Rev. 2012 Mar;17(2):263-70
8. Endogenous plasma erythropoietin, cardiovascular mortality and all-cause
mortality in renal transplant recipients 137
Am J Transplant. 2012 Feb;12(2):485-91
9. Erythropoietin is reduced by combination of diuretic therapy and RAAS
blockade in proteinuric renal patients with preserved renal function 153
Nephrol Dial Transplant. 2010 Oct;25(10):3256-60
10. High levels of endogenous erythropoietin and expanded extracellular
volume are independently associated with cardiovascular events in renal
transplant recipients 165
11. Discussion and future perspectives 185
Nederlandse samenvatting 206
Dankwoord 212
A tu
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S.J. Sinkelerr
on cardiorenal disea e