us food and drug administration: 2007-4285t1-index

8/14/2019 US Food and Drug Administration: 2007-4285t1-index

http://slidepdf.com/reader/full/us-food-and-drug-administration-2007-4285t1-index 1/35

00.1 [1] 154:6

0.5 [1] 206:6

0.55 [1] 136:2

0.75 [5] 88:14,19 89:3 92:4,7

11 [21] 89:11 91:11,20,21 92:3

114:8 121:22 127:9 135:22

151:22 165:14 191:4 206:6

217:1 222:16 234:12 236:14269:2 322:18 333:8 340:8

1,000 [1] 105:2

1-day-old [3] 119:16 120:21

122:17

1-point [1] 359:13

1-year [1] 247:21

1.0 [1] 154:7

1.3 [6] 257:13,14,21 259:4,8,

10

1.5 [2] 89:7 92:3

1.8 [1] 91:11

1/2 [2] 95:5,6

1/2-year-old [1] 192:19

1:00 [1] 217:3

10 [37] 3:8 32:20 59:13,22 61:

12 63:18,22 84:11 86:22 112:

18 113:7 119:17 127:19 142:

9 150:14 151:3 154:8 155:12

156:4 157:8 159:7,9 160:9

170:9,12 203:6 246:2,9 262:

5 264:12 285:19,20 315:2

328:4 358:17 359:15 361:18

10-fold [1] 206:12

10-minute [1] 147:8

10:55 [1] 147:9

100 [5] 88:5 198:3 232:9 235:

18 307:16

102 [1] 314:22

107 [2] 28:6 144:13108 [1] 3:19

10X [1] 206:10

12 [7] 142:17 159:22 170:9,12

232:14 276:22 277:10

12-hour [1] 149:22

12:00 [1] 217:2

122 [7] 66:2 93:22 164:13 166:

9 175:17 178:10 215:11

122-day [1] 170:4

123 [1] 164:13

124 [1] 141:7

13 [2] 220:11 276:22

13.2 [1] 235:9

130[1]

127:1314 [5] 119:18 121:22 162:18

192:13 277:1

14-day-old [5] 130:3,20 131:

4 132:1,5

147 [1] 3:23

15 [7] 144:11 151:4 159:9 264:

5 277:10 291:1 359:15

15,000 [1] 247:9

15-minute [1] 333:3

150 [2] 38:22 83:16

153 [1] 38:16

16 [2] 3:11 38:17

160 [2] 54:16 94:1

1750 [1] 1:10

18 [10] 62:22 69:18 133:1 144:

18 152:11 257:15 258:3 259:

7 276:19 317:6

18-gram [1] 133:2

180 [1] 295:19

183 [1] 3:26

18th [1] 220:17

19 [2] 63:3 276:19

1934 [1] 28:5

1937[1]

28:51938 [2] 28:10 29:20

1945 [2] 141:6,6

1962 [4] 28:17 29:11,21 30:11

1966 [1] 29:17

1968 [1] 29:22

1971 [1] 30:5

1973 [1] 30:10

1986 [1] 143:19

1989 [1] 30:19

1994 [1] 31:8

1995 [2] 31:11 227:18

1997 [1] 31:12

1998 [2] 31:17 32:1

1999 [5] 11:4 42:3 53:8 75:16

306:4

22 [51] 17:4 60:6 62:9 73:1,10

87:8 89:7,12 91:21 92:2,4,21

94:6 95:6,6 104:14 120:5,21

127:6 129:21 130:12 131:8

133:16 141:22 142:18 152:5

153:4 159:19 163:5,7 165:14

182:19 192:19 200:2 201:2

204:15 205:22 223:3 236:6,

15 247:1 257:15 258:3 259:6

260:5 276:10 295:21 333:9

334:9 340:8 345:21

2-hour [2] 151:14 159:3

2.26 [1] 88:17

2.3 [1] 88:17

2.7 [1] 60:13

20 [29] 22:22 41:12 42:18 44:3

59:14,15 60:9,15 63:18 64:2

87:1 107:15 108:9,14,19 144:

11 149:21 150:17 151:14

154:10 155:12 157:8 166:18,

20 170:16 191:5 277:9 308:

16 340:5

200 [1] 88:4

2000 [1] 44:13

2002 [4] 32:5 46:4 47:11 53:5

2003 [5] 32:13 54:4 133:22

228:5 268:192004 [4] 46:11 59:6 62:15 72:

22

2005 [1] 64:15

2005P-0076 [1] 222:16

2006 [2] 91:5 220:11

2007 [1] 1:6

2009 [1] 201:6

2014 [1] 303:3

2015 [1] 201:8

2050 [1] 235:9

20s [1] 277:4

21 [1] 272:18

22 [2] 28:15 170:16

220 [1] 4:4

224 [1] 4:6

229 [1] 4:8

239 [1] 4:10

24 [24] 53:9 59:11 65:2 154:21,

22 159:13,22 165:1 166:14

169:5,6 171:12,15 172:5,17

173:14,17 174:21 176:3 178:

18 179:6 216:5,8 353:15

24-hour [5] 66:3 173:3 174:

17 175:18 337:22243 [1] 4:12

249 [1] 4:15

25 [4] 39:9 88:5,7 108:18

256 [1] 4:17

260 [1] 4:19

267 [1] 4:20

27 [1] 189:7

28 [2] 268:13 269:8

28-day-old [1] 273:16

29 [1] 1:6

2A [1] 148:20

2B [1] 148:21

3

3 [41] 17:7 21:20 23:19 66:591:9 104:15 120:21 133:3,16

143:13,16 144:20 157:1 163:

7 165:1 166:14 170:7 173:14

176:4 178:17 179:6 183:8

191:21 203:15 204:3 206:12

212:8 215:19 223:7 247:1,10

257:18 258:7 262:6 264:6

276:10 286:14 334:10,10,11

352:4

3-day-old [1] 119:16

3-hour [5] 173:1 174:16,22

204:1 337:22

3-year-old [2] 286:11,19

3:30 [1] 333:4

30 [15] 63:18 64:5 86:3 87:3

91:9 127:13 189:7 211:12

212:2 219:12 225:10 247:5

277:9 296:17 342:12

300 [1] 110:17

309 [1] 4:21

30s [1] 277:4

32 [1] 200:3

33 [1] 268:13

35 [10] 66:2 113:8 134:22 164:

16 166:11 172:7 175:22 178:

12 179:16 214:11

35-day [1] 214:20

3M [1] 251:2

44 [29] 39:8 89:2 91:9,22 92:5

102:6 120:6 123:2 129:22

130:12,17 131:8 132:10 135:

20 136:12 138:15 139:4 151:

22 152:5 153:4 188:18 197:

22 200:2 204:15 223:10 287:

15 341:3 342:22 352:4

4,000 [1] 29:19

4-fold [1] 130:18

4-hour [2] 90:7 92:7

4.5 [1] 235:7

4:05 [1] 365:21

40 [10] 63:18,19 64:5 87:1,4

113:2,8 134:22 212:7 351:17

41 [1] 3:14

48 [1] 65:2

55 [30] 3:3 64:21 66:2,5 69:20

95:5 127:18 133:3 136:9,11

140:4 151:17 164:15 166:10

169:7 175:19 176:2 178:11

188:19 201:2 206:10,11 223:

13 234:13 257:16 258:4 305:

11 321:16 340:7 345:22

5-fold [1] 206:9

5-hour [1] 204:4

5.5 [3] 95:3 203:17 204:2

50 [11] 61:12 69:20 86:2 108:4

130:1 140:13 166:20 198:9

269:19 346:10 351:17

57 [1] 143:14

58 [3] 39:1,8 142:1

66 [49] 55:10 88:22 94:5 117:10

119:4 120:6 121:18 122:7

123:2 125:17,18 131:1,9 132:

2,3,9,11 133:7 151:14 152:8

153:2,5,7 154:20,21 159:6,12,

14,20 160:17,20 171:10,13

189:8 204:15 212:4 236:7

246:9 257:12,15,21 259:5,8,

11 283:19 284:19 305:11

340:4 361:17

6-hour [2] 66:4 166:15

6-hours [1] 54:10

60 [1] 269:6

600 [1] 345:6

612 [1] 142:17

62 [1] 82:9

64 [1] 264:8

68 [1] 112:20

77 [28] 42:18 44:4 53:7 59:10,

13,22 60:16 65:3,7 112:17

113:7 118:22 119:17 123:5

125:18 149:22 150:2,4 162:

19 189:6 191:18 192:8 193:4

272:18 285:19 305:11 314:1

362:10

7,000 [1] 249:20

7-day [2] 122:20 295:18

7-day-old [13] 42:8 43:5 46:8

118:18 119:9 122:17,20 123:

15 131:6,21 132:3,22 256:20

7-fold [1] 60:20

70 [3] 28:1 84:11 112:20

72 [1] 65:1

74 [1] 3:16

75 [5] 136:1 164:12 166:9 175:

18 179:10

79 [2] 30:15 316:17

88 [9] 80:10 143:16 197:22 200:

2 225:13 275:5,9 317:6 361:

18

8-year-old [1] 143:16

8:00 [1] 1:7

0.1 - 8:00



80 [3] 86:5,17,20

99 [8] 3:5 63:19,20 149:22 165:

2 179:3 188:21 358:19

9-hour [1] 42:20

90 [3] 42:19 44:4 59:13

92 [2] 30:15 316:13

93 [1] 31:1

94 [2] 169:2,7

95 [1] 169:8

97 [1] 90:8

99 [3] 53:14 90:8 272:15

AA's [1] 141:10

A-beta [25] 236:4,10,11,19

237:1,1,5,11,13,15,19 238:1,

3,4,8,11,18,18,21 239:1,3,7,9

263:2,4

A-beta-5-CQ [1] 238:2

a-la-carte [1] 254:1

A.D [2] 235:7 239:8

a.m [1] 1:7

abdominal [1] 73:7aberrant [2] 75:4,12abilities [1] 194:6

ability [20] 34:6,8 35:3 37:22

161:17 165:16 184:3 233:3,

14 258:9,14,20 259:12 260:4,

11 309:17 311:13 325:5 346:

15 357:6

able [29] 38:16,22 46:14 61:8

65:3 72:12 85:6 105:3,8 116:

6 126:21 149:12 151:2 152:3

153:19 155:9 179:22 196:17

226:12 276:5 277:8 308:6

344:6 349:8 357:1 359:9,22

360:11,20

abnormal [3] 317:9 359:8

360:3abnormalities [3] 19:21 25:7

26:19

abnormally [3] 98:4 100:20,

21

above [4] 64:22 87:1 88:6

330:8

absence [9] 68:19,21 82:4 90:

2 91:14 103:15 250:13 267:

11 317:18

absent [1] 99:10

absolutely [9] 122:2 130:6,

20 132:15 135:6 206:18 214:

19 292:1 342:20

abstract[3]

186:15282:

6

309:11

abstracters [1] 281:21

abuse [12] 83:12,18 220:3

221:12,22 222:7,8,11,18 223:

11 225:1,8

abused [5] 83:16 222:12 226:

5,13 228:15

academia [2] 66:16 99:2

academic [1] 325:21

Academy [2] 29:18 30:2

accelerate [2] 51:8,12

accelerated [5] 31:13 77:17

87:4 92:19 186:21

acceleration [1] 245:17

acceptable [2] 26:1,12

accepted [5] 12:12 65:18

167:22 168:2 175:9

access [2] 221:9 222:11

accidentally [1] 220:18

accompanied [1] 248:6

accompanying [1] 92:11

accomplished [2] 21:16 212:

12

accordingly[2]

190:17 216:17

account [1] 152:13accounted [1] 140:16

accumulate [1] 248:12

accumulating [3] 52:12 53:1

67:13

accumulation [3] 162:6 235:

12 236:19

accurate [1] 38:7

accurately [2] 104:7,17

achieve [2] 153:20 295:22

achieved [2] 101:1 207:12

acid [2] 17:18 194:22

acidosis [1] 185:5

acknowledge [1] 70:11across [11] 82:7 90:7 122:11

166:1 169:8 271:3 315:1,2,4

357:7,8

Act [8] 28:11 31:13 32:6,1462:3 116:5 328:3,3

acted [1] 39:10

ACTH [1] 317:11

Acting [2] 2:2 9:19

action [6] 30:12 70:3,6 209:

22 294:16 313:7

actions [7] 17:20 222:3 223:

20 240:16 283:4,7 322:11

activate [11] 76:14 129:12,16,

17 131:19,19 299:3 300:2,6,8,9

activated [7] 80:6,19 107:8

128:22 138:2 139:16 299:16

activates [2] 79:20 129:10

activating [1] 299:8

activation [29] 79:19 80:3,12

90:21 95:11 107:12 129:5

131:6,8,15,16 132:2,5,8 139:

6 235:15 236:8,13,16 237:9,

12,17,19 238:14,20 299:7,17

300:3,15

active [3] 241:16 272:11 280:

4

activities [1] 255:7

activity [8] 62:10 149:3 229:21,21 238:16 241:22 360:14,

14

actual [5] 114:15 152:16 153:8 191:17 204:22

actually [138] 43:2,17 44:7 45:

19,21 49:5 51:4,17,20 52:18

54:21 64:5 65:1 67:16 99:8

106:14 107:10 108:16 109:

20 113:18,20,22 114:10,17,

21 115:3,11 116:16,18 117:

20 118:5 119:12 120:1 122:

12 123:11,13 124:8,8,14 125:

16 126:6,14,19 127:3,4,22

128:3,5,9,10 129:4,6 132:19

134:4,9 136:6,17 137:21 138:

2,18,19 139:9 140:10,16 141:

2,21 142:4,10,14 143:1,6,11,

21,22 144:1,3,7,14,16 147:6

153:19 166:21 188:6 198:22

204:14,16 205:19 206:10

208:11,18 209:8 213:3 228:

21 229:10 267:15,22 268:10,

12 269:12 270:7 273:1 276:5284:16,21 286:4 294:21 295:

17 299:6,13,19 300:2 305:10

307:21 309:12 310:15 311:6,

16 318:16 321:6,19 322:9

326:10 327:3 333:4,14 336:5

339:1 340:13,19 342:5 343:7

345:5 350:8 351:14 353:3

354:12 358:8 364:10

acute [5] 34:10 239:5 274:7,

18 275:20

acutely [1] 274:10

add [11] 107:4 132:16 154:14

156:6 249:3 287:17 313:21

329:11 333:21 335:13 364:1

added [3] 11:10 61:10 329:5addict [2] 221:5 279:6

addicted [3] 226:15,18 279:7

addiction [5] 223:11,14 225:

13 226:17 228:15

addictive [2] 226:5,6

adding [3] 61:17 137:20 329:

13

addition [10] 11:19 13:11 38:

6 45:6 46:5 244:20 245:3

246:17 248:8 330:21

Additional [17] 11:9,18 36:465:9 69:12 87:12 162:2 223:

7 241:12 244:7 303:22 313:6

319:6 333:18,19 334:2 365:19

additive [2] 70:18 87:20

address [15] 10:11 14:14 24:

4 89:16 120:18 191:13 209:

17 219:6 222:6,19 224:6 272:

4 280:10 294:13 365:8

addressed [4] 73:21 244:14

288:16 333:14

addresses [1] 9:5

addressing [2] 277:21 320:

17

adds [1] 111:8

adenomatoid [1] 21:11

adequate [7] 24:19 25:20 26:

4 29:8 246:8 310:22 354:15ADHD [1] 316:20

adjourned [1] 365:20

adjunctive [3] 97:16 99:3

250:18

adjust [1] 190:16

adjusted [1] 216:16

administered [12] 25:7 34:

11,20 42:19 57:14 59:22 63:

18 64:17 223:17 247:12 281:

22 351:9

ADMINISTRATION [16] 1:2

23:6 37:12,14 39:17 43:7 44:

3 59:18 66:3 77:11 177:14

218:7 244:22 245:18 255:9

280:2

adult [18] 24:11 33:3 34:1 50:

8 51:1 63:6 86:18,21 109:8

244:9 248:5 250:1 258:16

259:3,10 324:9,15,20

adulthood [1] 212:4

adults [9] 73:3,5 109:15,16

187:18 255:3 259:1 277:3

301:2advances [1] 108:5

advantageous [1] 341:18

advantages [1] 289:12

adverse [17] 25:19 26:9 33:

22 34:6 36:19,21 37:10 38:4,

20 39:4,13,14 204:1 244:5,9

248:12 323:8

adverse-reaction [1] 26:20

adversely [1] 17:11

advice [1] 334:17

advise [2] 218:16 219:3

ADVISORY [6] 1:5 2:4,12 5:5

9:9 218:11

AERS [5] 36:21 37:19 38:5,13

39:18aesthetically [1] 251:4

affect [13] 17:11,19 47:8 119:

12 156:17 210:16 236:9 239:

6 258:19 259:12 280:21 296:

16 339:20

affected [9] 119:6 124:14

138:22 159:5 240:18 278:11

298:15 302:3 339:1

affecting [4] 165:15 257:10

349:10,11

affectionately [1] 118:17

affects [3] 19:18 235:7 299:

12

afford[1]

114:6afternoon [3] 14:13 147:3

260:18

afternoon's [1] 40:16

afterward [1] 208:12

afterwards [3] 160:20 192:12

355:2

age [58] 17:8 21:21 23:19,22

24:6,7 32:4 37:20 38:18 62:

10 69:5 101:20 102:21 108:

19 118:22 119:4,13 122:11

123:5 125:18 127:13,14 140:

4 142:1,17 143:14 144:20

150:4 162:18 163:5,7 193:1,

15 200:2,2,3,3 211:12 212:2,

4,7 220:13 258:16,17 259:3264:6,7,16 268:13 275:6,9

285:20 307:21 316:18 321:

16 345:21 359:16 364:21

age-matched [1] 122:14

aged [3] 179:15 257:2 265:1

agencies [1] 12:7

agency [15] 27:17 36:18 37:

22 41:20 44:13,17 46:13 47:

22 59:1 66:1,17 72:21 220:8

326:10 332:21

agenda [2] 9:11 10:6

agent [24] 76:22 88:11 89:2

80 - agent



4,5,22,22 136:22 140:2,3 151:

11,13 152:4 160:3 163:22

165:10,13 166:17 167:2 168:

5,16,17,19,22 169:4,7,10,12

170:7,11,13 171:9,18,20 172:

4,9,18 173:17 174:1 176:6,7

179:15,16 180:8 211:2 214:

21 215:19,21 216:7 232:2,11,

15 262:9,15 268:10,13 283:

14 284:4,7,18 285:2,21 291:7,

11 295:21 312:20 318:8 321:10 343:10

animals' [1] 165:15anisotrophy [1] 274:14

Ann [1] 345:20

announcement [1] 9:4annual [1] 199:5anomalies [1] 195:18

another [22] 83:7 103:3 109:

22 128:12 146:15 156:13

158:10 169:19 172:21 173:7

194:1 210:22 215:17 230:8

302:16 309:22 320:22 335:6

336:9 348:16 351:12 357:16

answer [17] 15:9 86:1,13 101:

3 133:19 200:5 213:18 214:18 231:1 243:9 277:8,10 285:

22 334:20 341:22 361:3 364:

12

answered [2] 314:12 365:5

answers [1] 348:15

antagonism [1] 210:12

antagonist [13] 42:12 43:9

48:12 51:19 71:9 76:18,20

84:2 117:6,9,13 210:6,20

antagonistic [1] 19:4

antagonists [7] 50:22 66:21

82:17 181:22 209:18 297:16

318:22

anterior[3]

123:1 131:10 132:3

anterodorsal [1] 81:15anti-emetic [1] 251:16

anti-epileptic [4] 194:21 279:

4,11 281:2

anti-epileptics [2] 278:14,17

anti-opioid [1] 225:18

anti-P [1] 300:2

antibodies [1] 80:6

anticipated [2] 235:5,6

anticonvulsant [1] 82:19Anticonvulsants [1] 83:20

antidote [1] 339:19

antisense [10] 154:15 155:16

156:6,11 157:11,15 158:14160:11 178:4 338:7

anxiolysis [2] 35:2,10

anybody [5] 274:22 333:15

334:8 363:22 365:3

anyway [2] 273:10 308:1

Apaf-1 [1] 79:19

apart [1] 42:19apologies [1] 345:13

apoptogenic [6] 83:12 84:14,

15 85:12,14 92:17

apoptosis [78] 18:8,14,15 19:

8,15 20:12 43:11 50:9 51:3

65:3 79:14 90:22 91:1 92:22

98:12 104:1 107:1 114:1,16

115:8 122:7 128:21 150:16

152:16 155:8 156:1 158:7

160:22 173:10 174:4,12 177:

9 186:21 235:16 236:4,15,18,

21,22 237:5,7,9,15,17 238:7,

10,10,14,20,21 239:1,7,9 241:

16 242:1,3,4 256:16,19 257:5,

18,21 258:2 259:6 267:2 269:

3,7 270:11,17 274:8 294:20296:1 298:22 299:8 300:11

338:21 360:3 361:5

apoptotic [24] 11:6 12:14 43:

13,17 48:13 49:19 50:3,18

55:11 63:17 78:10 81:20 115:

11 128:18 150:9 174:8 177:

18,21 274:12 282:5 297:11

300:13 329:6 351:3

APP [5] 236:9 237:10,13,19

238:17

appear [5] 17:9 19:14 25:11

53:18 309:9

appearance [2] 9:7,16

appeared [1] 65:2

appearing [1] 87:4appears [6] 12:15 48:17 49:3

106:7 160:21 352:2

appendectomies [1] 141:10

appendectomy [1] 141:8

Applause [1] 365:17

applicability [2] 14:20 310:

11

applicable [2] 24:7 271:16

application [4] 29:12 32:3

227:18 279:5

applications [2] 32:16 320:

12

applied [4] 39:1 290:19 295:

17 327:13applies [1] 118:7

apply [5] 35:3 118:9 291:10

312:19 315:5

applying [1] 180:8

appreciable [1] 95:10

appreciate [6] 23:7 37:7 224:

20 243:14 266:17 329:22

appreciative [1] 365:11

approach [25] 45:16 47:13

154:3 156:1 181:9 242:13

251:18,20 290:12,13,18 314:

19,22 334:18 336:21 337:12

339:13 341:5,6,13,13 359:12

360:8,9 362:1

approached [1] 280:11approaches [10] 156:20 165:

19 175:14 180:3,16 181:10

289:14 290:7,21 339:16

appropriate [11] 20:13 33:13

56:11 202:18 208:13,14 308:

6 325:22 354:17 359:21 361:

21

appropriately [3] 63:2 113:

21 228:9

approval [13] 13:17,17 27:1828:1 31:13 34:4,7,13 36:17,

18,20 38:15 39:5

approve [1] 29:12

approved [13] 22:17 23:3,4,6,

18 29:20 30:3,16 31:11 33:3

42:11 47:20 356:5

approximate [2] 49:4 87:20

approximately [11] 49:6 60:

7,12,20 73:10 76:5 82:9 88:4

94:5 188:19 247:1

APSF [2] 248:8 249:8

ARDS [1] 347:18

area[22]

57:18 100:7 106:11148:1 149:10 169:19 171:22

172:1 191:10 203:19 206:6

245:6 289:3 294:12 300:21

319:11 323:18 325:11 327:9

340:9 358:4 359:20

areas [16] 43:12 50:7,20 57:6

130:16 150:8 155:13 181:14

188:17 244:6 245:7 267:8

269:19 275:16 276:12 323:

18

aren't [5] 82:2 84:10 187:17196:13 309:4

arena [1] 58:8

argument [5] 89:20 90:1,16

91:3 92:14arguments [2] 89:16,19

Arlington [2] 4:3 220:9

Arm [2] 126:4 128:12

armamentarium [3] 231:9

320:2 322:4

armed [1] 306:3

Armstrong [13] 2:17 8:5,5 71:

16,17 273:21 275:12 311:22

313:12 319:8 327:12 336:12

358:11

aroma [1] 250:11

around [27] 5:6 76:7 83:15

86:9 101:6 115:17 126:13

163:4 164:13 169:2,7 170:9,15 178:17 192:8 206:6 215:

20 224:2 258:17 283:22 306:

18 325:11 326:5 328:8 345:

13 363:18 365:2

around-the-table [1] 332:17

array [4] 107:12 293:1 301:7

360:8

arrest [3] 291:17 331:11 346:5

arrived [2] 44:7 80:3

Art [3] 4:5 224:18,19arterial [11] 90:6 100:13,15119:22 120:4,14 134:16 137:

8 190:3 257:10,11

arteries [1] 197:13arteriosus [3] 185:1 196:16

343:16

artery [1] 91:10

Arthur [4] 2:33 3:11 5:22 13:

20

article [6] 11:6 168:1 185:16

186:13 306:4 309:11

articles [1] 250:14

artificial [2] 187:10 193:10Aspect [3] 4:11 53:16 243:22aspects [4] 16:16 128:17 148:

10 201:18

assay [6] 152:7 154:4 157:5

158:10,22 296:5

assess [9] 20:13 31:20 38:4

180:10 242:7 268:1 291:8

343:3,8

assessing [2] 23:21 361:5

assessment [16] 14:16 31:2

38:8 160:9 171:4 180:4,7

205:10,15 208:5 290:10 356:

21 357:12 358:13,13 363:1

assessments[3]

47:16 197:19 201:2

assigned [1] 26:17

Assignment [1] 25:17assist [1] 15:22

assistance [1] 12:6

Associate [3] 8:6,7 274:20

associated [14] 11:13 16:14

18:14 19:19 22:4 77:7 214:

15 236:22 244:21 256:2 274:

4 278:16 327:20 364:4

association [5] 131:14 245:

21 246:11 247:19 293:4

associations [1] 247:4

associative [2] 244:8 248:11

assume [4] 69:22 209:1 214:4 353:19

assuming [1] 157:14

assumption [3] 136:20 214:

5 270:5

assumptions [2] 297:21 298:

2

assure [1] 190:6

asymmetric [1] 353:18

Athena [2] 2:25 7:18

atmospheres [1] 295:21

ATP [1] 240:15

atresia [1] 196:15

attempt [5] 146:15 176:9 178:

13 343:22 352:11attempting [2] 14:19 180:17

attempts [1] 176:11

attend [1] 219:20

attendance [1] 219:1

attending [1] 6:22

attention [7] 76:19 105:22

182:14 248:3,5 266:12 285:

16

attenuate [3] 237:18 238:3,6

attracted [1] 348:18

audience [2] 200:6 243:20

August [2] 220:11,17Australia [2] 200:15 213:9

Australian [1] 344:1

authority [2] 27:22 32:13authorized [1] 223:12

authors [1] 145:5

Automated [1] 348:20

automatically [1] 253:16

Autonomic [1] 240:9

autopsies [1] 361:20

available [19] 13:13 14:16 20:

15,16 23:2 24:11 27:3,11 40:

10 52:19,20 73:6 146:10 169:

16 180:14 186:10 201:7 227:

10 331:17

average [1] 351:17

animals - average



aversion [2] 62:18 63:1

Avinza [1] 226:19

avoid [1] 255:20

avoided [1] 40:9

awake [2] 254:12 318:14

aware [9] 10:7 107:9 213:9

251:9 252:2 288:15,17 308:5

340:11

awareness [6] 198:20 199:4

221:14 250:4 253:1,12

away[10]

133:7 221:3 226:12283:17,18 284:9,19 297:7

307:9 321:12

axis [1] 317:9

Aynsley [1] 316:10

Bbabies [13] 28:19 109:2 140:4

187:19 213:4 272:12,20 285:

9 308:19 317:2,4,6 331:22

baby [5] 20:22,22 203:2 283:

17 301:22

BACE [2] 237:21 238:16

back [29] 34:15 80:1 100:19

133:7 141:6 144:6 147:9 163:

14 169:22 184:1 194:14 206:16 227:15 238:9,19 284:18

286:5 287:15 296:7 303:13

316:7 322:22 330:2 332:9

339:22 357:7,19 358:1,10

Background [4] 3:7 10:22

227:4 230:13

bad [8] 36:5 138:20 183:18

201:15 232:19 285:1 304:14

355:18

Bailey [1] 345:21

Bakersfield [1] 4:10

balance [2] 117:15 324:18

balancing [1] 116:5

ballot [1] 315:14

balls [2] 78:21 115:5

banana-flavored [1] 291:4

band [1] 172:19

barbiturates [4] 83:17 194:5

319:14 328:22

barely [1] 133:3

bars [1] 170:8

base [8] 13:11 15:3 57:18

297:22 302:21 353:6,6 364:8

Based [36] 9:11 24:17 25:17

26:8,20 42:10 44:12 46:12

48:15 66:13 68:2 69:5,10 73:

9 101:22 115:20 126:6 129:6

146:9 160:22 161:11 162:21

163:1,7 172:11 204:17 205:17 207:9 230:20 268:17 302:

11 305:12 308:21 310:13

347:10 359:6

baseline [1] 122:1

basic [5] 126:7 206:16 266:9

298:7 330:7

basically [15] 84:2 108:22

110:10,20 111:9 113:14 120:

8 126:21 183:16 184:15,22

202:5 230:11 250:10 258:6

basis [12] 29:20 164:20 167:

17 195:16 207:11 212:21

240:6 270:2 305:22 325:17

327:4 345:2

bath [1] 203:2

batteries [2] 352:12 354:21

battery [6] 290:13,18 348:20

354:14 358:17,19

bax [5] 79:16 98:6,10 155:6,

14

bax-dependent [1] 79:15Bcl [1] 129:9Bcl-2 [1] 155:6

Bcl-X[3]

129:15 130:6,11Bcl-XL [2] 129:7,22

BDNF [4] 299:10,12,15,19

BDNF-dependent [1] 300:9beautiful [1] 100:19became [2] 226:14 251:9

become [9] 35:13 71:13 79:4

225:17 226:18 250:8 293:4

320:7 326:12

becomes [6] 79:7 121:3 253:

6 278:22 287:5 359:11

becoming [2] 66:19 213:21

beer [2] 226:11 229:2

beg [1] 224:5

began [4] 28:2 149:11 164:10,

17begin [7] 13:15 74:19 147:10

182:19 204:19 296:8 359:16

beginning [8] 65:12 66:18 78:

12 94:22 112:17 218:15 219:

3,7

begun [2] 166:19 181:13

behalf [1] 9:19

behavior [5] 17:13 209:7 210:

16 290:17 356:14

behavioral [32] 11:20 19:2147:16 54:16 63:5,9 67:11

106:13 107:16 125:16 142:2

144:18 145:17 165:13,16

208:8,11 209:12 210:22 268:17 275:21 282:4 283:14 285:

7,15 290:8,10,21 291:3 323:7

346:11 359:4

behavioral-affected [1] 343:

10

behaviorally [1] 125:21

behind [1] 215:2

belief [1] 351:20

believe [32] 15:10 36:6 49:6

70:18 86:17 89:22 92:10 93:

13 102:18 110:4 111:6 112:

10,16,22 157:22 202:1 214:

17 218:8 240:1 242:7 245:3

248:13 249:7 259:19 265:14

272:15 280:18 286:2 305:1313:5 329:21 334:13

believed [2] 112:15 241:2

believes [1] 218:12

beneficial [3] 72:17 97:17305:10

benefit [4] 21:5,12 27:2 33:19

benefits [7] 21:14 25:22 26:

11 251:17,20 254:18 255:19

benign [1] 242:19

benzodiazepine [1] 208:11

benzodiazepines [4] 83:17

84:9 194:5,22

besides [1] 323:2

best [14] 24:1 32:5 45:16 47:2

121:5 132:16 133:13 134:2

286:6 304:17 306:15 328:3

334:18 358:21

beta [5] 230:22 231:20 232:4

235:11,12

better [7] 59:3 100:7 127:8

133:10 179:7 215:20 284:1

between [46] 17:4 29:20 30:

15 38:14 48:19 56:20 58:1064:5 65:2 87:3 94:2 98:6 101:

9 115:10 116:5 117:16 144:9

149:20 154:21 158:3,16 160:

6 162:13,16,17 163:16 166:

20 169:3 179:7 181:21 207:9

208:20 228:9 237:4 247:6,19

262:4 274:18 282:19 283:5

286:3 293:13 324:18 341:16

346:12 347:2

beyond [1] 142:6

bicarbonate [1] 137:7

BID [1] 227:20

big [5] 121:4 263:20 308:17

320:1 326:4

biggest [2] 104:5 146:1bilateral [1] 124:12bilaterally [1] 80:14

Bill [6] 99:15 203:12,12,14,21340:3

binges [1] 105:17

bioinformatics [2] 314:19,

22

biological [4] 30:7 31:19 32:16 138:11

biologist [1] 220:7

biomarker [4] 180:17 229:22

271:1,3

biomarkers [8] 106:10,12

165:20 289:2,14,18 292:21299:3

biopental [1] 319:14Biostatistics [1] 8:1

biphasic [1] 337:11

bipivacaine [1] 282:2

birth [19] 17:5 28:19 48:18 76:

4,6,7 110:12,16 162:17 164:

15,16 185:18 192:10,17 193:

5 241:17 256:12 314:17 332:

8

births [1] 109:1

BIS [3] 252:19 253:14 255:22

bit [29] 22:12 39:2 48:4 106:5

111:6 120:11 131:8 132:10,

11 139:3 143:20 152:20 170:13 171:1,17 176:1 177:19

184:1 212:22 216:14 230:14

232:8 252:10 267:12 274:1

299:13 341:5 343:12 345:15

black [1] 94:10

blank [1] 76:12

blebbing [1] 18:11

blind [2] 285:18,19

block [19] 67:22 71:8 75:18

107:7 154:17 155:1,17,19

156:6,11 157:12 161:6 178:4,

5 181:5 186:18 246:21 279:

21 281:6

blockade [5] 18:2,19 158:14

161:17 162:1

blockading [1] 160:11

blocked [2] 35:22 155:16

blocker [1] 281:4

blockers [14] 82:21,22 83:21

279:16,18 280:1,15,18,20

281:4,9,13 327:8,10

blocking [6] 11:8,14 51:21

155:1 181:1 210:7blood [28] 57:9 58:2 85:21 90:

4 91:20 92:6,9 94:4 99:13,20

103:22 105:17 120:5,14 121:

2,3,8,19 122:1 137:8,11 149:

16 168:3,5 190:3 253:22 257:

11,11

blood-gas [1] 119:22

blotting [1] 79:11

blue [1] 170:4

blueprint [1] 241:1blunting [1] 201:19

Bob [6] 2:30 3:8 5:9 300:12

311:2 365:7

bodies [1] 115:11

body [4] 15:5 17:15 57:18245:3

Bohnen's [1] 246:2

bolster [1] 317:13

bolus [2] 135:20 340:22

booth [2] 315:9,13

born [4] 19:22 28:19 111:7

112:20

borrowed [2] 42:22 48:8

Boston [6] 7:15 185:11 197:

11 200:16 250:8 303:10

both [46] 19:18 22:12 26:22

31:3 33:22 36:2 40:14 44:20

61:3 62:7 66:14 69:21 76:19

83:20 93:7 99:1,10 117:3148:11 166:1 169:8 172:1

177:15,18 185:19 197:22

198:14 218:7 232:16 238:16

241:15 242:6 246:10 263:12

265:14 266:9 267:5 278:10

290:19 291:6 292:2 295:1

325:22 330:7 356:21 358:9

bottom [4] 19:18 34:3 74:15

262:21

bought [1] 250:4box [4] 171:8 284:10 297:7,7

boxing [1] 321:12

boy [1] 220:10

BPCA [1] 328:2

bracket [1] 204:19Brad [1] 275:3

bradycardia [1] 185:7

brain [116] 11:13 12:20 16:21

17:21 41:17 42:14 43:5,15,

18,22 46:3 50:5,8,20 51:2,5

55:12 69:7 76:1 77:4,6,11,19

78:3 80:10,15,20,22 81:13,17

82:12 90:18 94:8,17,19 95:8

97:4 101:12,15,18,22 102:2,

15 107:10 110:15,17,17 111:

1,2,3,9 112:18,21 115:22 118:

19 119:10,14,18 134:7 136:8,

aversion - brain



12 140:5,16 145:20 150:7

153:1,3 163:8 173:9 183:13

188:18 192:21 194:8,15 195:

22 196:2 235:12 244:1 256:

20 257:5,17,17 259:6 261:8,

11 263:8,12,15 264:3 265:14,

15 269:3,5 272:11 275:22

279:22 282:17,21,22 294:21

299:11 305:16 314:15 321:

17 323:21 324:1,3,9,10,13,15,

20 338:2 340:2 359:8 361:7brain-growth [1] 17:1

brain-tissue [1] 152:21

brains [6] 35:17 76:21 94:18

104:20 167:1 171:14

Branch [3] 8:12 45:2 325:9

break [11] 14:11 147:6,8,11

179:4 203:6 216:21 326:6

333:2,3,6

breast [1] 247:1

breath [1] 190:2

breathing [1] 254:20

bridge [1] 249:19

brief [2] 13:16 350:17

briefly [3] 126:2 128:20 224:

22Brigham [1] 4:19

bright [1] 228:20bring [8] 15:10 144:6 161:17

284:17 323:17 330:15,17

357:16

bringing [3] 89:1 208:2 227:3

brings [3] 266:18 333:2 364:2

British [1] 316:12

broad [3] 101:19 193:3 248:

15

broaden [1] 261:6

broader [1] 339:17

bronchoscopy [1] 72:4

bronchospasm[1]

109:19brought [11] 168:4 208:18225:16 269:13 284:17 289:1

308:4 324:6 328:2 330:22

335:3

bulk [1] 141:9

bupinorphine [1] 225:22

burn [1] 303:13

burns [1] 303:9

business [2] 5:6 211:22

busy [1] 16:1

button [1] 311:16

bypass [1] 331:11

C

C57BL/6 [1] 86:1CA1 [1] 258:1

cage [1] 91:19

cake [4] 98:17,22 99:4 107:5

calcium [7] 149:2 161:15,18

162:2,6 176:20 177:4

calibrate [2] 205:21 318:7

calibration [1] 328:10

California [6] 4:10,15 228:20

239:21 248:8 249:17

Call [7] 3:2 5:2,3 111:5 118:16 222:5 239:16

called [10] 31:2 42:10 113:17

127:2 128:2 167:6 237:21,21

282:15 348:19

calling [3] 113:19 135:11 229:

11

calls [1] 305:8

Cambridge [1] 348:19

came [12] 76:12 122:21 132:

14 157:3 163:19 186:13 225:

14 266:15 286:4 314:4 358:1,

10

cancel [1] 100:22

cancer[9]

220:16 223:6 225:19 227:16 228:1 245:7 246:

10 247:1 274:5

candy [1] 134:12

cannabinoid [1] 107:17

cannot [23] 20:21 25:13 26:15 36:13 40:9 95:22 98:16

104:16 114:6 122:16,16 140:

16 210:15 211:18 212:12

268:5 270:1 284:15 286:1

287:7 297:20 298:1 356:1

cannulation [1] 91:10

CANTAB [2] 348:19 363:2

capable [1] 19:15

capacity [1] 360:20

Capillary [1] 240:5captured [1] 37:9

card [2] 237:2 263:8

Cardiac [5] 185:22 186:6 247:

14 291:17 346:5

cardiologist [1] 346:1

cardiovascular [2] 282:15

301:4

Care [32] 7:17 102:10 189:22

197:4 201:18 213:3 249:10

256:13 283:9 284:22 291:15

298:20 301:13,15,22 302:3,8

303:10,17 304:17 305:19,21

306:3,14 307:7 310:15 322:4

330:22 331:4 354:17 364:1365:3

cared [1] 224:1

careful [2] 10:18 359:1carefully [9] 121:19 151:9

223:8 292:8 317:15 324:5

341:19 354:22 359:13

cares [1] 125:3

carotid [1] 91:10

carried [1] 31:15

carry [1] 314:10

cartoon [1] 98:2

cascade [3] 98:12 240:8 300:

2

case [29] 42:17 60:3,6 73:1

93:21 105:14 123:15 130:15135:21 139:20 153:18 166:

15 188:2 194:8 207:1 231:11

232:11 262:11 283:18 284:5

289:19 298:4 302:2 305:9

344:4 349:22 355:22 365:5,

20

case-control [1] 246:7cases [13] 24:3 140:13 141:9,

10 190:19 249:20 251:13

252:17 292:6 294:9 307:12,

14 347:14

caspase [18] 95:11 96:6,9,11,

13 233:16,16,19 235:15 236:

13 237:9,12,17,18 238:20

257:18 258:7 300:14

caspase-3 [29] 79:20 80:3,6,

12,19 90:20 129:11,17 131:

16,19 132:8 137:22 138:3,6,

13 139:5,15 167:4 171:5 172:

3,12 175:12,20 236:8,16 238:

14 258:5 299:17 321:18

caspase-3-positive [1] 94:

11caspase-8 [4] 131:15,19 132:

5 299:7

caspase-9 [6] 79:20 129:10,

16 131:6,7 299:17

caspase-positive [2] 95:21

96:17

caspase-stained [1] 139:9

cast [1] 315:14

categories [3] 20:19 24:17

166:1

Category [13] 24:19 25:3,17

26:2,5,7,17 27:5,9,10 286:14

296:9,10

Cathy [3] 2:3 3:5 6:17

caudal [1] 278:8caudate [4] 87:13 88:8 94:9

96:15

causal [1] 347:3causative [1] 344:7

cause [15] 75:6 85:21 86:8 87:

20 90:13 91:6,7 123:7 213:

19 239:1 242:2,4 302:14 305:

15 355:9

caused [7] 28:18 76:18 79:16

89:4 145:18 193:18 283:6

causes [6] 79:18,19 88:7 232:

18 257:1 297:10

causing [3] 56:15 82:12 194:

7caution [3] 101:8 102:3,9

cautioned [1] 204:21

CBER [1] 182:9

CDER [8] 12:6 47:1 149:14,20

182:8,11 198:16 325:20

CDER's [1] 45:1

CDER/NCTR [2] 3:20 147:17

cell [75] 18:5,7,8,13 50:9 73:14 77:15 78:20 79:2,6,21,22

80:3,4,7,7 87:11,14 90:22

107:2 114:1,2,22 123:22 130:

9 139:16 149:2 153:17 154:9

155:10,14 156:5,10 157:5,8

158:1 160:16 161:15,18,22

162:6 167:3 171:8 172:8,11,16 173:7 174:8 175:14 176:

21 177:17,22 180:18 205:8,

11 231:17,21 236:8,11,13

237:10 240:14 241:11,15,22

263:11 269:3,22,22 270:2

277:3 299:1 338:5,10 339:10

cell-based [1] 240:11

cell-culture [3] 156:21 262:

22 287:20

cell-death [4] 152:7 154:4

157:5 161:1

cells [39] 18:10,12,17 80:22

81:1 82:1 124:3 139:9 150:9

153:20 154:5,18,19 155:22

156:3,8,18,18,22 157:22 158:

6,15,21 159:6 160:18 161:16

171:7,17 172:19,20 173:9

204:11 236:7 238:8 240:13

246:13 262:20 263:5 265:1

cellular [1] 240:15

cellularity [1] 269:9

CENTER [18] 1:3,9 5:15 7:10

9:14 12:1,2 30:5 44:20,22 48:2 65:16 147:16 200:17 249:

16,17 251:9,12

Center,Walnut [1] 4:14centers [1] 351:15

central [3] 110:10,11 240:8ceramide [1] 300:3

cerebellum [1] 95:15

cerebral [7] 121:8,16,19 122:1 260:5,5,8

certain [13] 17:17 21:6 38:19

94:5 101:20 117:21 125:22

160:15 278:20 289:12,17

292:3 299:7

certainly [75] 46:18 56:19 64:

7 70:11,12 71:21 72:10 109:7,11 112:8 120:16 121:2 133:

5 134:1 140:21 148:7 149:9

156:9 159:14 160:21 162:18

167:13 169:11 173:4 175:16

178:3 179:6,15 181:1,6 183:

21 186:14 187:13 189:6,10

190:8,16 192:6,14,22 193:11,

19 194:17 196:3 198:12 199:

9 201:16,20 226:6 229:20

271:21 279:12 286:18 291:

22 292:15,17 293:6,15 294:6,

11 295:20 298:6,10,19 302:

13 320:7 329:8 332:17 343:

12 346:18 356:16 361:9,15362:14 364:6

cervical [1] 278:9cesarean [5] 21:17 94:6 95:7

350:18 352:16

cetera [3] 205:2,2 215:5

Chahal [1] 269:5chain [1] 98:9

Chair [8] 2:2 6:8 8:6,16,18

168:20 218:5 253:10

chaired [1] 281:19

chairs [1] 168:20

challenge [5] 67:22 99:1 208:

6 277:5 308:8

challenges [5] 55:17 56:22

58:7,19 72:15challenging [2] 51:17 57:6

chamber [1] 284:12

chance [1] 147:21

change [12] 137:21 196:5

204:14 223:4 260:10 263:19

268:2,3,5,6 273:22 313:11

changed [4] 183:22 304:22

305:20 306:1

changes [37] 11:19,20 27:21

35:16 42:14 67:11 78:12,13

115:2 119:1 121:15 122:2

124:20 129:6 142:13 143:11,

brain - changes



15 144:18 168:5 188:20 189:

1 192:6 194:10 235:6 237:10

244:18 266:7 268:15 274:14,

19,21 293:7 299:6,14 303:14

343:8 360:21

changing [2] 108:16 304:10

channel [16] 82:21,22 83:21210:13 279:16,18 280:1,15,

18,20 281:3,4,9,13 327:8,10

channels [1] 281:7

chapter[1]

358:15characterize [5] 41:16,20 45:

4 47:13 341:8

characterized [2] 18:10 331:

15

Charles [4] 2:14 4:5,6 9:17

Charley [1] 8:20

Charlottesville [1] 6:15

chart [3] 27:21 191:17 359:14check [2] 253:17 263:20

chemical [3] 184:16 250:22251:3

chemicals [1] 30:7

Chemistry [2] 230:16 250:21

chemotherapy [1] 274:4

Cheng [2] 157:2 182:5Chicago [1] 220:8

Chief [2] 7:6 8:7

child [16] 71:22 72:3,3 109:8

141:13 192:20 211:15,20

276:1,2 286:22 302:8,19 307:

22 318:14 360:1

child's [1] 192:21

child-bearing [1] 31:4

childhood [2] 106:6 348:13

children [55] 15:16 19:22 20:

5 28:7 31:16,21 32:6,7,12 35:

16 36:5 44:15 72:1 109:4,15

110:3 141:7 144:19 145:9

146:20 208:8 220:10 222:21253:5 255:3 264:13 267:3

271:11,17 275:5 276:3,19,20

290:20 291:3,6 301:13,16

302:7 308:10,13,17 316:8,17

322:4 327:14,19 330:18,21

346:19,22 347:5 348:6 362:

19 364:20

Children's [7] 7:14,20 8:8

185:11 197:11 306:2 328:3

chloral [1] 23:5choice [3] 260:20 352:2 355:

19

choose [3] 219:6 302:11 304:

10

choosing [1] 298:16CHOP [1] 351:16

chose [1] 287:1

Chou [1] 228:4

chromatin [3] 78:22 115:4,5

chronic [3] 223:5 225:21 279:

4

chronically [3] 189:12 279:

11 286:15

Chrysanthy [1] 11:4

cingulate [2] 124:6,11

circ [1] 331:11

circuitries [1] 111:17

circuitry [3] 17:22 185:15,19

circulation [5] 62:17,22 196:

5,6 350:10

circulatory [1] 346:5

circumcision [1] 22:2

circumstances [8] 55:20 56:

4,10 75:4,13 221:8 279:17

304:3

cited [1] 358:16

Citizen [1] 222:16

clarification[1]

341:5clarified [1] 208:16

clarify [2] 71:19 208:4

Clark [1] 300:12

class [5] 320:22 322:11 331:

21 357:9,10

classes [4] 30:12 76:17 82:

15 83:4

classic [2] 164:19 167:3

classical [2] 79:7 172:15classification [1] 297:17

classifications [1] 38:20

classified [1] 301:5

classifying [1] 24:16

clean [1] 210:11

cleaning [1] 251:2clear [18] 32:13 44:16 45:22

48:16 58:1,14 66:19 68:3,8

71:8,11,17 228:11 242:4 278:

14 300:20 302:15 312:15

clearance [2] 214:16 215:3

cleared [1] 81:22

clearing [1] 110:3

clearly [16] 13:1 25:16 27:1

150:3 221:5 228:14,18 232:

18 280:3 313:8,22 314:17

316:5 324:1,14 331:22

Clinic [7] 4:5 142:6 180:20

246:2 317:12 358:2,10

Clinical[75]

3:24 7:19 8:3,1111:11 13:13 14:21 15:1,3,7

30:22 31:5 32:15 33:14 37:7

40:14 41:21 44:14 55:5 57:4,

8,15 68:3 117:22 120:17 140:

20 145:3 167:15 180:14 183:

1,3,10 188:7 206:1,2,4 213:8,

13,18 234:4 236:5 244:3,8,20

245:21 246:11,19 248:20

249:9 261:15 266:10 271:4,6

272:14 286:8 297:22 298:20

313:11 320:12 322:6 325:2,5,

6 330:2,3,7 333:12 335:4

342:14 343:2 351:4 358:1

359:1 361:8 362:4

clinically [11] 42:11 60:5 118:7,9 125:11 188:2 212:17 215:

15 279:18 307:4 321:5

clinicians [3] 23:2 37:3 202:

16

close [7] 37:6 133:9 152:17,

22 210:19 266:19 364:10

closed [1] 255:8

closely [7] 57:4 146:4 195:5

236:22 241:4 248:17 285:8

closer [3] 142:22 152:20 198:

10

closing [1] 223:22

clumped [1] 78:21

clumping [2] 115:3 213:10

CNS [3] 12:21 327:16 350:13

co-authored [1] 53:5

CO-oximeter [1] 168:10

CO2 [2] 137:10 253:18

Coagulation [1] 240:8

coal [2] 225:11,14cocaine-exposed [1] 276:

21

cocktail[10]

55:11 84:21 88:12,22 118:17 123:7 129:14,

20 142:21 209:13

cocktails [2] 84:18 212:16

cocky [1] 108:12

Code [2] 24:15 260:10

Coexisting [1] 196:22

cognition [3] 128:13 230:6

237:1

cognitive [46] 17:12 19:21

119:5 125:22 140:22 141:2

144:10,17 146:12 165:12

180:6 211:4,6,8,17 212:14

213:19 214:1 232:5,18,22

233:3,14 237:3 261:17 262:4,

11 263:22 264:19 265:22266:4,7 267:7 275:8,19,21

290:14 291:8 301:1 330:4

352:12 354:21 355:10,13

358:13 359:4

cognitive-function [1] 289:

9

cognizant [5] 109:22 287:12

306:6 308:3,17

Cohen [1] 248:7

cohort [5] 199:11 343:13,18,20 363:11

coincides [2] 75:22 123:5

Coleman [4] 4:10 239:19,20

243:12collaboration [1] 42:5

collaborations [2] 200:17

272:3

collaborative [2] 12:3 200:

12

colleague [3] 157:2 184:19

302:1

colleagues [9] 11:5 101:22

149:14 182:6 228:4 254:2

306:2 322:19 351:22

collected [4] 19:8 120:4 157:

1 268:12

collecting [1] 36:19

collection [1] 201:6

college [2] 220:14 228:20Colorado [1] 6:9

combination [36] 61:13 62:6,

12 63:16,19 67:14 69:21 85:

15 87:19,20 103:2,4 118:20

119:12 121:18 123:16 124:2

137:17 138:5,21 140:2 220:

21 221:2 231:20 246:16,20

263:4 268:10 296:12 299:12

334:19,21 335:22 336:3,4

341:17

combinations [11] 70:15

103:6,8,12 240:14 334:11

337:1,3 341:6,19 342:7

combine [1] 212:21

combined [4] 61:12 81:10

118:14 303:21

combining [3] 70:1 209:10

335:3

come [27] 97:9 106:4 116:13

121:5 133:7 135:10 141:4

170:5 194:14 226:20,21 231:

10 237:14,14 238:8,19 303:

13 315:2 321:1,9 327:18 331:2 332:9 349:14 352:16,20

353:1

comedications [1] 37:21

comes [12] 104:13 109:17

155:8,14 170:8 237:7 273:16

275:20 282:18 306:10 347:9,

16

comfort [5] 35:4 234:7 255:16 304:7 330:16

comfortable [4] 57:20 245:

20 304:2,2

coming [14] 9:8 11:3 65:16

66:16 74:5 134:2 168:1 170:

11 235:6 286:12 289:2 300:

12 314:20 362:18commen [1] 353:17

comment [26] 10:13 38:1

100:1 201:5 207:22 208:1,7

229:8 269:10 270:1 281:19

282:9,10 292:20 295:1 326:

16 331:13 333:20 334:9 335:

14 336:18 337:14 344:20

348:4 350:3 356:10

comments [5] 222:2 327:5

333:18 341:1 365:19

commercial [3] 83:2,5 84:4commit [2] 74:20 75:3

commitment [2] 33:6 79:22

committed[3]

80:4,7 139:16COMMITTEE [31] 1:5 2:5,13

4:20 5:5 8:18,22 9:9,12,21

11:2 16:11 45:11 182:18 218:

11,17 219:4,22 224:21 225:5

243:6,19 248:14 261:4 267:4

316:3 326:13 332:18,22 334:

17 335:1

common [6] 106:18 109:11

221:11 234:22 327:15 353:6

commonly [11] 19:6 67:15

109:15 117:12,19 125:10

135:14 187:4 213:12 236:2

238:13

communication [1] 361:10

communities [1] 15:13community [7] 15:15 198:13

199:8 200:10 202:9 248:4

325:21

comorbidities [2] 37:21 245:

12

comorbidity [2] 248:1,18

companies [1] 250:6

company [4] 10:1 234:20

243:22 256:10

comparability [1] 162:15

comparable [6] 95:22 99:15

101:20 227:15,22 228:2

changes - comparable



comparative [1] 275:4

compare [14] 82:8 122:16

132:10 138:4,18 165:22 198:

6 214:1 215:6 289:19 296:21

297:13 327:10 328:18

compared [24] 53:11 59:10,

12 92:6 121:22 122:12,20

127:11 132:1 135:21 139:9

140:13 150:12 158:21 171:6

172:5,17 233:20 247:12 272:

16 282:2 318:12 323:7 343:15

compares [2] 71:10 296:6

comparing [5] 60:4,10 66:5

69:19 160:6

comparison [5] 101:9 133:

16 207:9,11 273:2

comparisons [3] 57:19 106:

5 112:3

compassionate [1] 223:22

compelling [4] 254:18 265:

15 306:12,13

compensatory [3] 130:8 162:

4 212:3

competitive [1] 325:17

competitors [1] 218:19complete [2] 241:13 318:4

completed [2] 48:1 200:4

completely [8] 69:9 112:19

128:4 145:10 187:11 286:2

317:8 342:18

completes [1] 241:5

complex [7] 126:19,22 128:2

165:16 180:6 212:5 354:21

compliant [1] 124:21

complicated [1] 339:3

complicating [1] 292:4

complication [1] 252:12

complications [5] 109:11,14

199:1 245:8 277:2component [2] 155:18 275:14

components [1] 148:17

composed [2] 45:12 184:13

compound [4] 215:3 228:11

279:12 341:14

compounding [1] 344:13

compounds [17] 17:20 47:8

49:21 50:8 52:2 54:12 55:1,7

61:19 62:2 64:9 67:1,4 238:3

341:16,21 342:4

comprehend [1] 127:11

comprehensive [2] 208:5

222:9

compressed [1] 92:19compromised [1] 273:10

concentrated [2] 81:5,5

concentration [19] 88:13,16,

20 89:3,6,8,11 99:11 100:4

103:22 159:8 207:10 236:6

257:12 319:12 335:19 352:3

355:4,20

concentrations [28] 58:13

100:12,14 118:14 125:13

152:21 157:9 169:20 203:20

205:21 206:8 214:12,14 279:

22 280:4 295:18 296:1 318:8,

10,10,12 328:11 340:6 342:

20 350:9,14 351:1 353:3

concept [4] 64:7 142:15 174:2 288:17

concepts [1] 248:2

conceptual [2] 74:18 75:11conceptualization [1] 145:8

concern [10] 16:19 20:8 146:

16 246:7 272:8 273:15 302:7,

10 323:18 363:14

concerned[11]

212:1,8 213:8 216:14 222:15 253:2 301:

17 304:5,6 327:7 339:18

concerning [4] 12:1,17 100:

2 145:6

concerns [14] 11:10 14:20

33:18 44:14 71:20 183:16

244:5,7 249:9 266:16 276:15

302:3 303:22 313:4

conclude [1] 224:12

concluded [3] 220:20 227:19

228:7

conclusion [4] 123:9 239:5,

13 264:15

conclusions [5] 93:10 96:21

145:13,14 255:12concomitant [3] 321:3 329:

15,17

concomitantly [1] 335:9

concurrent [3] 57:7 282:13329:18

condensation [1] 174:6

condensed [1] 79:7

condition [4] 85:9 92:8 102:8

196:8

conditioned [3] 62:18 63:1

168:20

conditions [17] 17:11 18:8

20:21 21:6 25:18 54:1 85:2,8

90:11,12,13 92:2 187:14 205:1 291:20 292:17 293:8

conduct [6] 31:20 32:15 196:4,19 202:18 255:17

conducted [16] 19:9 23:22

24:21 32:11 33:2 41:13 42:

16 48:15 61:6,11 64:15 66:3,

17 70:10 220:20 247:18

conducting [2] 59:2 68:11

conduction [1] 47:20

confident [4] 290:20 345:17,18 357:3

confirm [4] 59:7 119:20 139:

19 145:16

confirmation [1] 12:4

confirmed [2] 46:8 53:19confirming [1] 60:17

Conflict [8] 3:4 9:1,3,5,15,16

239:21 243:21

conflicts [1] 230:2

confounded [1] 354:9

confounding [5] 196:20 199:

11 287:3 288:1 344:3

congenital [4] 21:10 195:18331:8 332:6

conglomeration [1] 191:18

Congress [2] 28:10 325:18

Congressman [1] 219:19

conjunction [1] 149:13

connect [1] 116:7connected [1] 142:13

connection [1] 218:22

connections [1] 111:16

consciousness [1] 254:16

consecutively [1] 251:14

consensus [2] 332:18 365:1

consent [1] 29:15consequence [1] 204:2

consequences[7]

186:22187:6 229:2 244:9,13 245:1,

8

conserved [1] 17:3

consider [25] 14:1 22:16 24:

14 109:7 113:19 182:2 193:2

196:3,19 201:17 222:4 231:6

233:10 245:11 251:7 264:3

279:20 297:18 306:20 316:4

317:15 318:19 336:13 339:5

352:9

considerable [1] 46:12

consideration [8] 56:18 70:

14 72:12 205:14 222:14 243:

6 245:10 329:10

considerations [1] 364:14considered [10] 108:15 113:

15 205:1,9,22 259:14 271:16

292:10 319:2 361:16

considering [7] 125:9 229:

20 242:6 249:4 256:5 261:4

283:7

consist [1] 29:8

consisted [3] 42:18 44:19 54:

14

consistent [9] 157:9,18 160:

8 174:10 176:17 177:1,2 343:

9,10

consistently [1] 216:16

console[1]

220:15constantly [2] 283:21 284:3

constructive [1] 97:10

consultant [1] 7:1consumed [3] 20:1 220:18

222:22

consumer [1] 265:6

consumption [1] 20:3

contact [1] 37:6

contain [3] 23:12,18 24:10

containing [2] 28:5 221:20

contains [2] 19:2 22:18

content [1] 102:1context [4] 218:13 281:3 294:

3 358:5

continue [10] 14:11 202:22221:17 244:17,20 248:12

287:11 316:1 341:15 364:14

Continued [2] 4:1 332:13

continues [1] 32:8

Continuing [1] 318:1

continuous [7] 134:16 167:

17 188:22 340:15,18,20 347:

20

Contra [1] 249:18

contracted [1] 29:17

Contrary [1] 257:20

contrast [6] 43:19 50:2 52:1

81:4 242:3 289:20

contribute [3] 52:21 58:4

197:6

contributed [3] 13:10,12 45:

15

contributing [2] 339:7 342:5

control [63] 30:12 57:9 80:2291:21 92:1,6 94:13,14 95:10

96:1,12,16 122:18,21 124:7,8,

9 127:3,17,20 128:9 130:1,19

140:14 142:7 149:1 152:5154:6 156:2 157:13 158:21

159:4,18 168:15,17,21 169:4,

5,8 171:6,9,18 172:5,9,17

173:8,16 174:5,22 176:7 182:

1 198:2 199:15 232:15 233:9

240:10 242:14 262:13 284:4

292:4,7 294:11 304:7

controlled [8] 114:12 137:12

139:5 199:10 227:22 343:21

350:7 362:18

controlling [1] 301:18

controls [21] 94:15 122:14

125:20 127:11,16 132:10

135:6,8,10,11,12 138:5 139:

10,22 150:13 160:8 211:3,14223:7 232:16 286:3

conundrum [1] 249:4

conversation [1] 345:13

conversations [1] 363:14

convince [1] 261:9

convinced [1] 325:3

convincing [1] 288:5

cooling [2] 292:12,12

Coordinating [1] 45:11

cord [9] 278:4,5,8,9,11 280:2,

19,21 329:7

core [1] 196:16

coroner [1] 220:20

correct[11]

68:22 69:1 157:14,15 202:13 219:20 295:13

334:7 339:4 353:22 363:18

corrected [1] 322:14

correctly [3] 70:17 206:1 280:

16

correlate [2] 49:3 104:17

correlated [3] 106:12 275:8

349:3

correlation [4] 103:10 105:9

136:10 247:6

corresponding [1] 17:6

cortex [25] 88:8 95:9 96:3

121:13 122:22 124:6,12 130:

10,16,22 132:3,6 139:7 153:

18 156:14,22 171:22 172:1193:17,17 258:1 267:19 276:

8 278:8 299:15

cortical [7] 101:15 121:7,16124:13 138:3 267:10 269:7

cortices [1] 123:2

cortisol [1] 317:11Cosmetic [1] 28:11

cost [1] 101:5Costa [1] 249:18

coughing [1] 252:10

couldn't [6] 125:19 133:18209:17,18 210:8 215:1

comparative - couldn't



coumadin [1] 241:19

Council [1] 29:18count [1] 311:11counted [2] 311:8 317:3

counting [1] 282:5

country [1] 326:5

county [3] 221:12 249:18,18

couple [11] 96:12 106:4 112:

11 161:10 189:22 251:13

262:12 281:21 324:22 353:2

359:18course [40] 54:6 81:10 96:21

109:5 121:20 132:9 135:20

138:15 146:17 149:1,7 151:8

155:21 157:13,16 158:19

161:3,17 168:11,17 169:20,

20 171:10 177:4 178:22 180:

4,21 190:16 196:4 204:10

215:19 252:12 254:10 279:8

285:5 294:5 318:6 334:20

340:20 358:1

courses [1] 329:2

Court [2] 30:10 31:21cover [2] 36:7 327:1

coworkers [2] 74:12 149:9

craniofacial [1] 105:7create [1] 283:1

created [1] 113:16

creating [1] 118:16

Creek [2] 4:14 249:17

Crile's [1] 242:11

crisis [1] 225:8

criteria [2] 258:15 353:7

criterion [1] 232:12

Critical [18] 7:17 37:11 49:1163:7 149:3 159:16 161:5 167:

9 169:21 205:7 237:2 255:4

256:13 292:2 324:9 330:22

331:4 360:6

critically[1]

286:15criticism [1] 146:1

Crosby [6] 4:18 260:17,18,19

266:13 298:11

Cross's [1] 257:2

cross-sectional [1] 359:13crosses [1] 128:7

croup [1] 273:17

crucial [2] 116:6 208:3crucially [1] 117:16

crucified [1] 132:15

crude [3] 104:11,13 297:17

cruel [1] 147:7cry [1] 143:4

CSF [1] 350:14

culprit [3] 89:21 91:5 92:15culture [12] 73:14 153:17 154:

3,5 156:3 158:15,21 160:18

204:11 231:17 236:11 263:

12

cultured [1] 236:7

cultures [3] 155:11 157:7

256:18

cumulative [4] 72:2,6 123:1,

22

curare [2] 24:3 184:14

current [7] 10:12 13:12 15:3240:6 267:1 319:18 364:8

currently [11] 11:16 48:1 82:

16 93:4 116:15 135:5 235:7

291:11 319:21 339:15 348:

17

Curtis [1] 227:16

curve [9] 100:8 167:19 191:

11 203:19 246:6 319:11 335:

20 340:9 353:11

curves [3] 328:17 342:7,11

cut [3] 82:6 219:13 345:12

cutting[1]

81:13cycle [4] 236:18 238:10,21

239:9

cyclopropane [1] 143:7

cystic [1] 21:10

cytochrome [9] 79:18 129:9,

16 130:9,14,15,17,21 131:1

cytokine [1] 299:2

cytoplasm [4] 78:11,13 79:6

115:10

cytotoxicity [1] 232:1

DD-aspartate [1] 18:3

daily [4] 117:20 285:9 305:22

327:4damage [22] 107:8 122:13

123:8 124:19 125:3,7 146:3,

8 193:18 267:17,20 268:20

272:20 273:7 275:18 278:15

279:12 297:11 302:4,14 305:

15 362:13

damaged [2] 76:21 140:9

dampened [1] 170:22

Dan [5] 3:14 5:18 7:22 41:4

72:20

danger [1] 221:10

dangerous [3] 221:9 278:22

318:16

Daniel [4] 2:17,24,32 14:4

Danny [1] 8:5

dark [5] 43:11,12 81:19 170:3

172:20

Data [147] 3:12 12:1 13:6,8,14

14:17 15:1,5,7 19:7 20:11 26:

9 30:8 32:3 33:21 35:20 36:

16 37:2,3,5,9,18 38:1,5 40:

14 41:5,7 42:9 57:17 63:7 67:

13 69:5 72:5,8,10,13,20 73:2

91:17 93:6,8,11,13 99:12,15,

18 106:6 107:9,9 145:6 151:

12 157:10,19 158:4,4 161:12

162:8 163:1 166:5 167:18

168:2,8 169:11,15 171:2 173:

19 175:12,13,13 176:17 177:7,16,16 178:8 179:20 193:12

198:7 201:6,7,22 202:21 203:

15,16 204:11,17 205:4,16

206:13 214:18 232:7,10 233:

16 234:4,6 248:15 261:9 263:

18 264:17 265:16 267:9 270:

13 280:10,14,17 282:7,15

288:18 293:17 294:16,17

298:13 301:3,6,7 306:12,13

308:6 309:20 310:10,17,22

312:17,19,22 313:2,5,11,22

314:2 315:6 318:3 319:6,11,

15 328:8,10 329:8 331:14,16

334:15 337:21 338:1 342:8

343:12 356:12,16,17

Database [13] 36:21 37:1,19

38:5,14 39:18 40:3 199:2

247:9 267:1 309:6,8 318:4

databases [1] 291:2

date [7] 12:21 14:6 19:7 71:

14 309:17 311:12 341:6

daughter [1] 220:12

daughter's [2] 221:20 224:5

Dave[4]

125:14 209:5 254:9335:2

David [2] 2:11 7:8

Davidson [1] 200:15

Davis [2] 228:22 249:1

day [42] 53:7 59:10 61:12 62:

21 63:3 65:7 66:2,2,5 93:22

110:10 127:9 150:2 157:1

162:19 166:9,10,11 169:7

172:7 175:17,19,22 176:2

178:10,10,12 179:16 215:11

216:6 220:14 258:4 285:8,10,

19,19 301:21 314:5,17 333:5

362:10,10

day-35 [3] 169:9 170:13 172:

9day-5 [2] 170:10 171:18

days [46] 17:4 54:16 65:4 81:

21 94:1 105:18 112:18,20

113:3,7,8 118:22 121:22 123:

5 125:18 127:6,8,13,14,18,19

134:22 140:4 153:21 162:18

164:14,15,16 184:11 189:5,5,

6 192:8,13 193:4 206:4 211:

12 214:11 220:13 268:13

271:12 273:19 285:20 321:

16 347:17 353:2

de [2] 2:10 3:26

deactivation [1] 338:21

dead[3]

123:21 124:4 358:19deal [4] 55:22 144:1 196:9225:7

dealing [3] 302:6 303:8 307:

17

dealt [2] 132:21 133:2

death [46] 18:5,7,9,10,13 50:

10 75:7 77:15 80:1,4,7 87:11,

14 90:22 107:2 114:2,2,22

123:22 154:9 155:14 156:5,

10 157:5,8 160:16 167:3 171:

9 172:11,16 173:8 174:8 175:

15 176:21 177:17,22 180:18

205:9,11 228:18 269:4,22,22

270:2 273:7 299:1

deaths [1] 224:14debatable [1] 112:9

debate [2] 262:1 323:14

debilitating [1] 196:22

debris [1] 82:1

decade [1] 235:6

decerebrate [1] 252:5

decide [3] 305:3 354:12,13

decided [6] 47:1 88:22 89:5

119:13 135:13 251:13

deciding [1] 355:1

decision [1] 355:21

decision-making [1] 218:9

decline [3] 232:18,22 233:14

declines [1] 242:2

decrease [11] 70:7 82:6,10

129:15 130:6,12 238:4 274:

13 300:3 321:3,15

decreased [4] 104:15 140:12

299:19 331:20

decreases [1] 274:15

decreasing [1] 180:22

decrement [1] 346:10

dedicated[1]

225:6deep [10] 95:12 96:6,8,8 186:

2 190:9,11 247:20 252:10

346:5

deeper [1] 339:14

defect [1] 347:16

defective [2] 17:21 18:17

defects [2] 28:19 256:12

defer [1] 73:17

deficit [2] 105:22 211:4

deficits [18] 55:12 62:9 63:5

104:8,11,14 105:6,11,22 196:

18 198:9 213:19 263:15 266:

5 290:21 296:19 301:2 355:

13

define [3] 100:3,6 351:10defined [3] 86:5 290:11 337:9

defining [5] 178:13 181:16

293:20 359:5 360:11

definitely [4] 96:17 347:12,19

348:3

definition [2] 73:13 100:9

definitive [5] 15:9 97:7 273:1,

8 347:10

degenerating [1] 81:2

degeneration [8] 51:1,14 77:

20 78:1,5 81:10 102:17 278:

7

degenerative [2] 81:22 95:

13degree [7] 15:6 62:8 64:12

122:6,9 250:21 299:8

degrees [3] 20:5 105:21 317:

8

delay [6] 22:10 152:12 153:6

283:1 364:4,19

delayed [3] 22:5 36:13 352:

18

delaying [2] 36:9 364:16

delays [1] 195:2

delete [1] 277:17

deletion [1] 82:11

deliberate [1] 242:19

delineate [2] 341:20 344:6

delirium [1] 244:21deliver [3] 140:3 258:9 307:6

delivered [4] 20:22 214:16

349:19 352:22

delivery [5] 20:21 21:14 280:

12 353:4 355:5

delta [1] 345:1

dementia [2] 237:3 276:18

demographic [1] 32:2

demonstrable [1] 227:7

demonstrate [3] 24:21 155:

22 287:11

demonstrated [9] 12:14 26:

coumadin - demonstrated



18 35:15 149:20 244:2 245:2

256:16 261:20 264:18

demonstrating [1] 19:7

denominator [1] 38:8

dense [2] 77:19 81:6

density [4] 140:12 257:18

258:5 321:16

dentistry [1] 116:16

DEPARTMENT [4] 1:1 6:5

256:13 361:12

dependency[1]

158:13dependent [2] 129:1 236:14dependently [1] 256:17

depending [1] 50:16

depends [3] 49:13 97:3 259:

19

depressant [1] 197:5depressed [1] 198:9

deprivation [4] 282:21,22

283:5 287:19

derive [1] 232:10

derived [2] 19:2 334:15

dermatologists [1] 143:22

describe [4] 48:5,10 51:7

176:9

described [8] 42:13 48:14 51:3 75:21 76:1 165:5 205:5

293:9

describes [1] 240:7

describing [5] 11:6 13:5 52:

15 55:21 243:3

deserved [1] 151:1

deserves [1] 326:4

Desflurane [1] 30:18

Deshpande [13] 2:18 7:5,5

207:22 282:9 307:11 312:6

313:18 322:1,15 330:12 333:

19 334:7

design [6] 56:22 126:22 163:

19 166:3 202:18 290:6designate [2] 309:17 311:13

Designated [1] 6:18

designed [13] 33:15 47:6 59:

6 118:11 125:6,15 188:4,5

213:9 215:8 222:10 354:22

359:13

designing [3] 153:11 267:21

364:15

designs [2] 343:3 348:5

desirable [1] 229:16

desired [2] 117:22 121:13

desires [1] 134:14

Despite [3] 25:10 26:1,12

destination [2] 111:15 113:

13detail [5] 36:7 52:15 231:18232:9 279:3

detailed [1] 40:13

details [4] 221:20 242:21 345:

4,8

detect [7] 34:6 36:16 43:11

65:3 105:3 175:14 359:9

detectable [1] 237:10

detected [3] 105:5,5,6

detecting [1] 104:14

determination [1] 38:8

determine [13] 12:8 30:20 52:

8 146:14 200:6 239:12 248:

21 257:9 266:2 310:10 325:

21 360:1 364:17

determined [11] 9:13 46:13

79:22 91:13 105:10 199:17

257:17 258:3,5,14 358:17

determining [3] 102:17 104:

7 205:7

detrimental [3] 12:21 282:4317:20

devastated[1]

124:3develop [17] 57:3 97:16 99:2

101:18 136:12 180:11,17,22

222:9 232:5 270:18 285:4

289:22 332:2 356:20 359:8

360:15

developed [16] 12:3 110:12

112:21 140:5,17 142:2 162:

14 167:6 180:6 185:5 234:11

275:22 290:18 291:2 321:17

356:18

developing [33] 11:13 12:20

41:17 42:14 46:3 47:15 50:5

55:12 74:19 77:4 81:17 104:

19 116:11,12 117:17 118:1

147:14 149:5 165:18 180:5183:13 200:14 234:14 248:

16 256:19 257:5 265:14 282:

21,22 285:11 299:11 344:12

361:12

development [61] 16:21 18:643:22 47:19 49:13 51:6 52:3

55:22 56:6 63:8 69:7 77:16

81:2 101:12,15 102:2,20 104:

9 106:6 110:14 111:3 112:18

116:2 118:19 119:5,10,15,19

134:7 136:8 144:10 145:20

148:13 160:15 162:22 163:8

164:7 178:9 179:8 198:18

212:14 234:8 236:1 240:12241:2,3,5,8,14,15,21 244:13

245:22 270:16 272:12 277:

19 285:17 305:16 314:14

315:7 351:21

Developmental [23] 3:15 56:19 74:4,7,21 75:17 101:16,17

102:16,20 148:9 173:11 195:

2 199:20 275:14 282:16 283:

1 315:1,4 317:22 336:14 344:

9 348:7

developmentally [1] 276:3

deviation [1] 346:8

devote [1] 182:20

dexmetatomidine [2] 320:

10 335:8di [1] 293:2diagnosis [2] 347:14 361:22

diagram [2] 43:4 163:15

dial [1] 255:22diameter [1] 82:7

diazepam [8] 61:13,14,20,22

62:7,13 69:20 347:21

die [9] 18:12 113:22 115:17

139:16,17 140:15 221:17

361:17,18

died [4] 220:21 221:4 229:2

331:1

diethylene [1] 28:6

differ [2] 109:16 112:5

differed [1] 122:10

difference [17] 123:17 159:

19 169:3 204:5,13 211:5 258:

18 262:4 276:5 286:3 293:13

296:13 305:17 343:14 344:9,

9 363:10

differences [16] 56:3,13,20

62:5 91:22 92:5 187:13 191:

3,6,7 204:7 273:8 323:21324:3 341:16 359:10

different [88] 33:16 42:18 48:

20 49:12 52:2 56:13 58:10,

12 62:1,3 70:2,9 76:3,4 78:4,

6 79:13 82:15 84:1 96:4,4,7,

7 101:12 102:15,18,20,22

103:12 106:7,20 107:1 110:4

112:5 119:13 125:20 141:14

150:7 156:4,7,17 158:1,3

159:4,13 163:9 164:12 166:1

171:4 175:14 177:19 178:3

180:3 181:3 190:8 191:9,19,

21 198:1 199:8 204:17 207:

13,20 223:15 232:9 256:17

277:18,18 286:14 295:17301:4,7 314:22 315:2 319:1

328:21 329:2 336:14,22 343:

1 349:1 352:11,17 353:13,14

355:15,16 362:21

differentiate [2] 111:16 283:

5

differentiated [2] 75:1 288:

13

differentiating [1] 282:19

differentiation [1] 17:21

differently [1] 73:15

differs [2] 18:9 296:3

difficult [16] 38:4 57:13 58:20

101:21 115:12 207:7 210:14212:10 287:5 296:22 298:16

325:3,7 344:14 351:10 358:

14

diffusion [1] 360:18

diffusion-tensor [1] 349:3

Dilantin [1] 281:4

dilemma [2] 97:2 104:21

diligently [1] 326:19

dilution [1] 269:18

dimension [1] 82:7

dimensions [1] 249:3

Dimes [1] 256:11

direct [7] 40:21 133:17 136:

10 218:19 243:14 266:21

309:21direction [2] 164:11 360:18

directions [1] 271:2

Director [6] 5:10,13,15 6:4

147:15 249:22

dirty [1] 210:2

disabilities [1] 145:9

disability [3] 256:21 257:2,7

disaggregates [1] 78:22

disagree [3] 309:13 310:4

311:17

discard [1] 314:15

disclosures [1] 224:20

disconnect [1] 227:2discontinued [1] 171:11

discontinuous [1] 79:5

discordant [1] 316:14discover [1] 354:16

discriminate [1] 360:13

discrimination [1] 290:16

discuss [9] 14:22 58:6 84:20,

20 85:2 147:2 310:9 312:16

315:11

discussed[9]

22:12 288:19290:3 323:19,20 324:12 329:

5 330:19 333:8

discussing [2] 280:6 312:17

DISCUSSION [22] 4:20 10:4

14:14 40:13,13,17 55:16 147:

3 182:19 266:19 267:4 276:7

280:9 282:11 310:8 312:14

313:22 315:18 318:2 322:8

334:10 358:20

discussions [4] 45:6,9 46:12

358:12

disease [22] 26:14 187:13

230:12,22 231:16 232:5,6

233:2 234:10,11,14 235:1,3,

13,17 236:1 245:7,18 263:3271:13 273:12 332:6

diseases [1] 223:6

dish [1] 119:3

disorder [2] 106:1 232:6

disorders [3] 186:17 230:12,

19

disperse [1] 79:1

disposition [2] 215:4 294:2

disrupt [1] 241:21dissector [1] 138:1

dissolution [1] 78:17

dissolve [2] 84:8 124:10

dissolved [1] 84:14

distant[1]

37:13distinct [4] 45:22 51:2 52:1

233:13

distinguish [1] 91:1

Distinguished [2] 219:22

273:14

distributed [1] 309:11

distribution [1] 87:14

district [1] 31:21

disturbances [5] 75:9 76:10

77:7 103:11 106:19

divergent [1] 365:3divide [2] 111:7 191:20

divided [1] 347:2

Division [7] 5:10,20 6:1,4 13:

21 14:15 147:15divisions [1] 45:14

DMSO [4] 83:6 124:9,9 284:6

DNA [3] 129:11 240:22 241:3

Dobbing [2] 101:21 191:16

Doctor [1] 229:6

doctors [1] 223:11

documented [5] 11:18 222:8

223:5,18 234:9

doing [22] 126:21 147:22 151:

10 152:18 161:16 200:19

201:2 211:8 231:12 251:7

253:19 267:16,22 271:6 287:

demonstrated - doing



12 293:1,16 297:4 304:10

306:15 338:8 355:11

domain [1] 66:15

domains [1] 328:15

dominoes [2] 98:7,15

Don [1] 8:14

Donald [1] 2:21

done [72] 36:12 68:18 90:18

108:13 109:3 114:18 115:21

117:7,10 118:4 122:19 126:

20 129:4 133:8 134:1 136:4141:14,17 142:10 143:15,20,

21 144:7 146:18 166:14,21

168:10,16 170:1 178:21 182:

12 190:19 193:1 195:15 196:

1 197:10 202:22 209:4,12

210:17,18 213:15 229:4 255:

5 256:3 272:14 281:15 287:

22 291:19 296:5,17 298:1

300:16 301:3 305:15 306:6

307:13,13 310:16 316:8 326:

3 328:15 348:3 350:13 351:

14,21 352:8,10 360:7,8 362:4,

22

dorsal [1] 278:10

dosage [1] 70:1dosages [1] 223:15

dose [68] 25:5 50:16 53:12,13

59:14 60:9 61:3 69:19,21 70:

5 86:9,14,16 87:1,5 88:2,6,

13 95:4 99:19 136:1 138:14

149:21 150:14,17,19 151:17,

18,20 153:2 155:10 158:13

164:20 165:2,7 166:17 171:

11 185:3 188:9,9,15,21 190:

20 191:11 203:19,22 206:1,2

214:15 215:13 225:19 236:

14 244:19 249:11 256:1,17

257:9 259:19,21 260:2,9 278:

19 335:21,21 336:7 342:12,13,19

dose-dependent [1] 64:10dose-related [1] 177:15

dose-relatedness [1] 150:

22

dose-response [13] 88:6

118:13 149:15 164:18,19

191:3 246:6 328:17 338:17

342:6,10,17 353:11

dosed [2] 151:14 228:9

doses [35] 25:4 53:17,20 57:

14 59:12 64:4,17 70:7 85:4

86:8,22 88:4 125:12 150:13

153:2 156:3 188:19 190:15,

15,17,18 203:17 206:5 207:3273:19 321:4 332:2 333:10

335:16,16 336:4,5 341:9,10

353:20

dosing [5] 23:13 33:15,17

206:4 227:20

dotted [1] 136:17

double [1] 204:3

double-blind [1] 347:1

Doubletree/Hilton [1] 1:8

doubt [4] 124:20 148:8 287:10 346:9

down [16] 24:7 39:1 89:1 129:

9 141:13 152:1 153:5 158:10

198:5,9 216:14 263:17 298:

15 318:13 327:2 336:8

downregulated [1] 314:7

downregulating [1] 360:10

downregulation [4] 299:15,

16,21 314:7

Downstate [1] 7:10

dragging [1] 115:17

dramatic [13] 37:16 39:15 85:

6 105:19 113:20 141:16 143:11 158:5 160:10 162:18 173:

15 175:17 324:2

dramatically [6] 108:16 122:

11 159:5 173:13 231:2 236:

10

dramatized [1] 28:8

draw [2] 93:9 346:11

drawn [1] 319:4

dream [1] 254:6

dressing [1] 303:14

drew [1] 76:12

drink [1] 226:11

drop [1] 151:18

dropout [3] 104:9,18,20

dropouts [1] 103:12dropped [2] 216:14 273:1

drops [1] 151:22

drove [1] 297:8

Drs [8] 11:9 13:9 14:9 42:3 60:

14 61:6 63:14 202:10

DRUG [94] 1:2,3 5:13 9:14 11:

16 12:1 13:17,18 20:16 24:

14 25:12,15,22 26:11 27:1,16

28:3,8,10,11,22 29:2,2,4,4,5,

13,22 30:11,20 31:9,12,19 32:

10,21 33:3,12,19 34:11 37:12

39:6,10 42:10,11 44:21 50:

17 56:6 62:8 64:13 67:17 70:

5 84:13 85:12,14,15 89:22188:22 191:7,8,9,11 192:13

198:17 210:11 218:7 220:3,

21 221:5,9,12 222:18 223:12,

19 227:18 228:21 231:4,8

240:19 251:1 255:14 262:7

280:4 294:1,2,15 320:22 322:

5 329:18 332:11 334:11 336:

2,11 337:3 340:17

drug-induced [2] 75:16 242:

9

drug-review [1] 45:14

drug-safety [1] 221:14

DRUGS [98] 1:4 2:4,12 5:5 9:

9 12:19 22:9,16,21 23:8,11

24:9 26:15 27:2,4,10,14 28:12 29:15,19 32:9,16 35:1 40:

2 41:17 44:10 55:21 66:19,

21 67:14 69:21 70:1,2,8 75:

18 76:17 82:19 83:4,12,18

97:18 99:3 110:4 186:10,18

187:4 188:1 190:17 194:3,21

195:8 197:5,6 210:2 226:19

227:3 229:11,16 230:17 231:

9 233:11 242:8 249:5 250:16,

17 251:7 254:1 275:10 279:

11 281:2,6 319:16,17,21 320:

14,19 325:4,13 327:21 328:4,

5,5 331:18,21 332:3 333:13

334:16,21 335:4,7,9,14,19,22

336:3,20 337:13 346:19

dry [1] 251:2

ductus [3] 185:1 196:16 343:

16

due [6] 109:19 110:5 156:1

196:7 220:16 264:20

dumped [1] 325:12

duplicate [2] 46:6 188:6

duplicating[1]

188:21duplication [1] 46:14

durable [2] 230:5 231:3

duration [25] 50:16 61:4 89:1,

6,7 133:18 145:22 164:21

165:7 176:11 178:16 179:2

188:1,18 189:5 191:11 203:

18 204:18 259:20,20 260:3,

10 271:15 272:9 284:9

durations [4] 49:12 204:8

333:10 341:8

during [57] 12:10 17:9 18:5

19:15 20:1,3,12 21:14 24:15

25:7,12,15 27:12 28:15 35:

18 43:22 47:19 55:22 77:16

81:2 85:12 93:19 101:1 104:9 110:18 111:20,21 112:11

114:5 120:15 121:16 122:3

147:3 164:7 184:11,13 186:6,

10 190:14,15 193:14,19 196:

3 201:20 202:6 220:11 241:

17 270:3 272:11 276:21 277:

19 279:8 305:10 316:9 317:

21 332:12 340:5

dust [1] 83:14dwindle [1] 23:15

dying [6] 123:21 124:4 150:9

155:22 156:1 172:20

dynamic [2] 184:9 186:9

dysfunction[4]

237:1,3 267:7 330:5

EE-VAD [1] 237:16

each [32] 13:10 70:5,8 78:4

80:15 85:14 100:22 102:18,

19,21 103:9 106:22 116:7

148:17 166:15 177:7 200:17

209:17,20 219:17 221:19

232:12 235:19 240:14 297:

18 300:19 301:7 303:16 336:

2,19 339:8 355:12

earlier [18] 39:4 87:3 101:17

113:17 135:1 175:4 178:9

179:12 208:15 262:17 263:21 266:3 329:5 330:14 331:1

333:20 362:9 363:13

early [15] 10:20 12:13 21:1 78:

10 84:4 103:3 110:18 115:6

184:1 212:14 240:3 316:7,19

331:15 332:4

earmark [2] 325:19,20

ears [1] 142:19

ease [1] 255:17

easier [2] 255:7,10

easily [1] 168:12

easy [3] 121:9 162:13 253:10

eat [3] 98:22 99:4 107:5

eating [1] 98:17

Eckenhoff [11] 4:7 142:10229:7,8 234:15 235:20 239:2

245:14 246:1 298:8 330:4

Eckenhoff's [2] 213:15 234:

21

editor [1] 198:21

Editor-in-Chief [2] 6:12 7:3

editorial [1] 248:7edits [1] 199:6

educated[1]

228:20educational [1] 198:20EEG [1] 244:18

effect [64] 25:20 58:12 71:7

73:16 77:13 87:21 95:13 105:

3,4 120:2 144:1 149:17 151:

4 152:6,9 153:7 154:22 156:

6 157:12,14,17 159:13,15,21

160:10,11 161:6 166:21 174:

18 176:9 179:2 181:6 184:20

185:12 191:6 192:13 200:13

203:16 204:20 206:12 208:

22 210:8 221:3 237:18 255:2

263:1,7 288:14 295:3 296:13

298:2 317:16 323:9 327:16

335:11 337:9,9 338:4 339:5,5,8 340:17 344:7 351:3

effective [3] 85:9 210:7 223:

19

effectiveness [6] 29:6,19 30:

11 32:4 223:14 331:20

effects [87] 12:18,21 16:20

19:5,12 20:2 21:2 30:7 41:16

47:14 48:11 50:4,21 58:5,9

65:6 70:18 78:14 114:19 140:

22 141:2 145:5,7 146:12 147:

13 150:21 151:15 152:14

157:21 160:2,21 166:2 168:

13 173:4,22 175:6 176:13

177:4 178:11,18 179:19,21181:1,8 185:13 194:2 202:3

203:17 209:6,9 210:12,13,13,

22 214:2 229:16,18,19 230:5

240:19 241:21 242:5,8 244:

15 246:22 248:12 260:22

261:10,16,18 265:16 267:11

275:11,19 282:4 283:2 288:

13 295:3,11 297:5 299:10

301:4 317:20 319:8 324:19

327:14 359:7

efficacious [2] 24:11 33:17

efficacy [11] 23:21 29:4,22 31:

9,21 32:6 227:8,11,15 228:1,

2

effort [1] 12:4efforts [5] 32:19 33:21 45:21

57:12 325:20

eighteen [1] 220:13

eighth [1] 355:5

Eisenach [24] 2:7 6:10,10

103:13,14 195:3 279:15 280:

14,22 281:5,16 312:10 315:

19 324:21,22 326:15 330:2

335:2 337:3,6 349:16 350:2

352:14 353:12

Eisenach's [2] 199:6 281:19

either [29] 36:11 62:8 64:13

doing - either



84:2 97:6 116:17,20 118:12,

14 124:4 156:2 162:8 166:14

178:10 183:18 185:2 188:9

200:22 201:14 228:7 233:1

237:2 257:22 258:16 263:5

301:16 337:22 347:20 351:6

elderly [4] 248:17 264:11 289:

10 330:5

elders [2] 264:16 265:5

elective [4] 305:7,9 307:15

364:22electroencephalographic[3] 328:14,16,18

electron [4] 78:8 81:13 90:21

300:14

electron-microscopic [1]

81:11

electrophysiological [1] 54:17

element [4] 115:13 211:9 283:

15 305:2

elements [3] 114:14 116:2

221:11

elevated [3] 85:21 86:2 105:

17

elevations [1] 242:4eliminate [3] 253:7 286:1

308:22

eliminating [1] 18:17

ELISA [2] 154:4 161:1

elixir [1] 28:5

Ellen [2] 200:15 228:16

eloquently [1] 249:2

elucidated [2] 35:1,9

EM [4] 173:20,22,22 174:2

embryological [5] 241:1,2,5,7,10

embryonic [3] 62:15,21 63:3

emerge [1] 276:4

emergence[1]

244:21emergency [1] 192:16

emergency-room [3] 188:12

322:16 323:13

emergent [3] 195:15 307:18

349:22

emerging [2] 240:1 317:1

Emily [8] 220:12,17,21 221:4,

5 223:22 224:10 228:17

Emily's [1] 221:8

emotional [1] 275:9emphasize [7] 93:12 239:10

264:1 265:12 266:2 270:21

300:18

empiric [1] 336:19

empirical [1] 243:8employ [1] 97:13

employed [2] 10:2 11:16

employee [1] 243:21

enact [1] 28:9

enantomers [1] 288:14

encompassing [1] 342:19

encourage [1] 57:2

encourages [2] 218:14 219:

2

end [6] 38:15 119:18 179:10

216:12 305:16 332:2

end-organ [1] 190:6

end-tidal [4] 137:10,10 252:22 253:12

ended [1] 22:11

endorsed [1] 30:11

endpoint [4] 68:3 117:21 141:12 345:16

endpoints [7] 54:15 163:9

165:13 199:21 207:18 290:9

318:8

ends [1] 337:19

energize[1]

240:15engage [1] 249:7

engender [1] 15:11

England [2] 185:17 316:11

enhance [1] 237:20

enhanced [7] 221:2 231:22,

22 233:19,20,22 234:2

enjoys [1] 110:17

enormous [3] 110:18 111:8

363:8

enough [10] 61:22 69:16 93:9

138:8 195:5 298:17 301:19

310:17 345:7 346:16

ensure [2] 29:3 218:10

ENT [1] 347:14

entail [1] 90:20enter [1] 188:11

enterocolitis [1] 344:13

entire [3] 30:12 74:16 79:6

entirely [1] 58:14

entrance [1] 353:7

entry [1] 360:12

environment [4] 30:7 76:2283:11 211:16

environmental [5] 17:10 47:8 51:7 106:20 220:7

enzymatic [1] 240:16

enzymes [3] 237:21,22 238:

15

Epidemiology[1]

38:13epileptiform [1] 244:18

equal [3] 38:17 364:18,20equally [1] 233:12

equate [1] 189:9

equation [1] 315:3

equipment [1] 167:16

equipotent [1] 118:13Equity [1] 32:14

equivalence [2] 344:18,22

equivalent [3] 60:8 103:21

314:16

era [1] 292:21

ergic [1] 229:12

error [3] 170:8 215:20 324:11

esophageal [1] 196:15especially [10] 27:13 34:10

35:14 145:18 149:2 178:1

212:14 233:10 252:8 327:10

essential [3] 15:14 154:16231:6

essentially [4] 153:5 251:14

255:13 347:8

establish [5] 28:8 29:14 209:

14 344:21 345:1

established [4] 30:6 45:3 66:

1 86:18

establishment [2] 44:18 57:

20

estimate [2] 69:8,9

estimated [1] 235:8

et [19] 19:1 42:3 46:4,10 53:4

59:6,8 60:15 61:6 62:15 64:

15 65:16 72:21 88:14 90:10

91:5 205:2,2 215:5

ethanol [22] 71:8 76:19 77:2,11,18 80:11,21 81:4,18,21 82:

12,18 83:18 84:12 85:19 93:

7,18 94:4 194:17 231:12 279:6,6

ether [3] 141:11 143:7 251:4

ethically [1] 325:2

Etomadate [2] 323:12 328:

22

Europe [3] 28:18,20 117:12

euthanize [1] 94:7

Evaluate [10] 3:21 29:19 47:7

56:9,18 97:11 147:18 156:8,

14 240:2

evaluated [6] 31:10 65:8,22

67:2,3 171:13

evaluating [2] 106:16 257:18

EVALUATION [9] 1:3 5:13 9:

15 12:2 33:11 44:21 54:17289:17 328:9

evaluations [2] 70:14 277:8

even [45] 9:6 20:4,8 31:8 57:5

73:14 102:4 104:11 124:18

132:22 133:9 135:12 138:12

146:4 162:2 179:12 180:14

185:18 190:12 202:2 207:1

211:22 212:20 216:14 222:

21 250:13,21 255:8 263:14

268:4 277:10 293:10 298:8

307:14 308:2 323:13 324:3,

20 332:12 337:12 339:2 340:

10 346:21 355:11 360:18

event[5]

10:4 36:21 37:10274:18 275:20

events [16] 33:22 34:7,8 36:

19 37:15 38:4,14,20 39:4,13,

14 101:15,16 245:1 247:14

315:1

eventual [1] 50:15eventually [6] 111:18 163:17

165:21 211:12,20 212:1

every-day [1] 286:5

everybody [3] 233:15 260:18

311:6

everything [8] 37:20 118:6

134:18 136:4 139:4 298:15

303:18 359:6

everywhere [1] 139:6evidence [40] 11:12 12:20 17:

15 21:4,13 25:1 26:8,20 29:8

36:5 53:18,20 60:1,10,16 65:

3 67:5 86:19 106:15 179:18

205:3 235:14 242:6 244:9

245:4,16 246:11 248:12 259:

17 261:16 262:9 263:6,11,13,

14,21 265:1,14,21 335:15

evolution [1] 27:17

evolving [2] 11:22 13:11

exactly [19] 53:7 58:1,14 68:7

71:10,11 78:1 83:3 116:10

137:12 139:22 250:16 269:

21 272:19 285:20 296:4,22

297:1,19

examination [1] 329:4

examine [3] 30:6 38:13 187:

10

examined [5] 62:17 70:17

154:21 167:1 334:16

example [24] 26:13 27:2 51:

16 56:12 78:15 84:9 104:14

114:22 132:21 137:19 148:21 210:4 218:20 270:19 285:

17 295:15 300:21 303:7 318:

11 338:14 339:9 350:16 351:

17 354:16

exceeded [1] 85:16

excellent [4] 126:7 267:15

284:16 365:14

except [7] 92:7 122:2 125:21

130:11 131:1 231:18,19

exception [1] 262:21

excess [1] 240:22

excessive [1] 18:18

exchange [2] 32:11 302:2

excitation [1] 116:22

excited [2] 100:21 224:4excitory [1] 193:20

excitotoxic [4] 49:16 50:13

51:14 90:22

excitotoxicity [4] 49:22 50:5,

22 51:21

exclude [2] 10:8 297:5

excluded [1] 31:4

exclusion [1] 10:9

exclusively [1] 141:15

exclusivity [3] 31:15 32:8,10

executioner [1] 79:21

Executive [4] 1:9 2:3 8:18

349:11

exhaustive[1]

109:14exist [3] 15:6 103:17 355:17

existing [3] 15:18 69:10 364:

13

Exogenous [1] 18:1

exogenously [1] 231:22

expand [1] 103:20

expansions [1] 278:9

expect [10] 15:8 129:13 136:

10 173:9 198:8 201:5 294:5,

7 346:10 358:15

expectancy [1] 48:21

expectation [1] 129:14

expectations [1] 131:17

expected [2] 48:21 114:5

expedition [1] 347:9expenses [1] 218:22

experience [6] 26:10,22 152:

10 226:6,7 227:5

experiment [6] 93:17 118:12,

13 285:3 292:4 353:11

experimental [18] 30:8 102:8121:11 122:17,20 125:20

127:8,15,21 135:21 137:16

139:21 163:19 187:21 189:8

284:7,18 285:21

experimentals [2] 139:22

286:4

either - experimentals



experiments [5] 95:1 122:19

163:21 164:3 268:9

Expert [3] 44:19 109:12 302:

6

explain [3] 258:11 306:5,10

explained [2] 233:22 258:13

explains [3] 240:4,17 242:11

explanation [2] 77:5 91:15

explicitly [1] 222:6

exploration [1] 289:2

explore[4]

248:9 249:9 319:17 342:7

explored [2] 270:12 294:3

expose [7] 93:19 116:11 153:

21 159:5,12 160:3 232:21

exposed [33] 11:7,21 12:22

20:5 47:18 55:10 88:21 105:

16 118:18 139:3 144:13 145:

19 154:19 165:14 176:6 226:

13 268:9 279:7,10,22 280:3

285:8 298:14 346:19 352:21,

22 353:13 354:2 355:3,14

359:15 360:1 361:19

exposing [4] 123:14 125:17

139:21 343:4

exposure [80] 12:18 13:3 20:12,14,19 34:10 38:9 54:1 60:

12 61:1,2 63:4 71:22 72:2,7,

22 73:9 85:4,11 86:11 100:3,

6,9 103:16 105:3 136:7 139:

20 146:19 159:14 160:9,17

171:12 172:17 173:1,2,3 175:

18 176:3,4,12 178:17,19 186:

18 188:1 189:9 195:7 204:8,

18,22 205:2 231:4 242:18

244:2,6,12,15 245:5,11,22

247:3,19 248:2,13,21 276:11

279:13 286:17 296:16,20

301:1 305:2 313:3 319:9 331:

16 332:4,13 333:11 341:8346:21 350:18

exposure-response [2] 278:

21 342:16

exposures [13] 59:19 60:7

72:7 104:3 157:20 159:2 192:

14 203:15 204:19 246:4 329:

2,3 363:9

expound [1] 333:16

express [2] 34:9 326:12

expressing [1] 330:1

expression [6] 107:7 241:3

299:2 318:6 328:10 338:3

extant [1] 31:19

extend [3] 16:10 46:7 59:7

extended [2] 32:10 127:19extending [1] 55:1

extends [2] 49:9 69:3

extensive [5] 125:2 137:16

197:17 268:6 319:4

extensively [1] 295:16

extent [6] 18:17 216:17 253:

14 294:22 321:2 333:10

external [2] 78:17 299:8extra [3] 10:19 31:14 253:20

extracted [1] 94:13

extraordinary [1] 280:3

extrapolate [6] 30:8 55:19

57:14 310:22 313:8 314:14

extrapolated [2] 15:7 313:4

extrapolates [1] 189:6

extrapolating [1] 293:12

extrapolation [3] 69:6 102:

13 104:22

extrapolations [1] 310:18

extreme [1] 330:14

extremely [3] 321:5 325:9

336:18

extremes[1]

324:8extremis [2] 184:7 197:2

extrinsic [4] 129:1 131:12

299:3 300:8

eye-opening [1] 163:9

eyes [1] 152:15

FFAB [1] 299:6

face [7] 55:17 58:19 68:1 143:

4 187:14 208:6,9

faced [1] 196:4

facets [1] 13:10

facilitate [6] 235:22 238:15,

17 239:8 243:7 251:12

facilities [1] 167:15facility [1] 167:14

fact [25] 48:15 115:15 125:9

176:5 185:18 186:8 212:11

229:22 231:13 250:9 262:3,

10,20 263:1 264:10 294:19

302:1 329:18 335:18,20 338:

6 340:1 346:20 349:20,21

factor [5] 89:10 248:1 302:18

316:14 360:12

factors [9] 235:21 296:12

299:10 346:22 347:2 350:1

357:17,21 358:6

fade [1] 23:14

fail [2] 253:2,3

failed [2] 24:21 350:15

failure [2] 75:6 247:15

faint [1] 96:13

Fair [6] 69:16 106:5 289:7

297:14 363:22 365:1

fairly [19] 109:11 118:5 134:

10 138:14 151:21 170:8 185:

3 219:15 252:10 272:17 278:

13 288:4 297:17 304:2 305:

21 321:19 333:4 338:2,2

fairness [1] 10:11

fall [2] 27:5 281:20familiar [2] 144:15 149:7

families [1] 224:6

family [2] 37:4 220:15far [23] 41:15 67:13 94:16 99:

19 112:5 120:16 125:12 131:

12 132:17 152:22 173:10

193:9 195:3 198:3 216:13

263:20 270:1 281:14 282:4

288:15 318:5 324:19 364:7

Fas [2] 131:18 132:2

fascicularis [2] 94:1 95:2

fascinating [3] 68:5 255:1

332:15

fashion [10] 24:5 34:21 146:

18 158:2 168:16 190:20 197:

15 231:3 299:14 359:9

fatal [2] 222:22 252:12fatalities [1] 39:9

fate [1] 139:14

father [1] 220:16

FDA [49] 2:28 3:20 10:6 15:14

19:2 23:3,17 27:16 28:21 29:

6,11,17,22 30:11,19 31:1,17

32:1,13 44:7,19 45:19 147:

15,17 149:14 182:8 183:7

202:11 218:11,14 219:2 221:

21 222:3,5 223:2 225:3 226:21 227:3,17 229:4 243:10,19

248:5,14 318:2 319:6 325:19

326:8 334:18

FDA's [5] 12:1,11 27:21 222:

14,16

FDA-approved [1] 23:12

FDA-related [1] 16:16

FDA-wide [1] 44:19

FDAMA [2] 31:13 32:9

feasible [1] 343:2

feature [4] 149:3 154:11 169:

21 360:6

features [1] 79:8

February [1] 33:10

Federal [5] 6:18 24:15 28:1031:21 325:10

feed [2] 135:8 284:2

feel [13] 156:7 174:18 176:16177:13 185:20 215:22 221:

21 270:22 290:9,20 325:8

326:11 357:2

feels [1] 326:14

fellow [3] 117:8 184:19 267:

16

felt [1] 158:15

female [2] 73:15 168:14

females [1] 169:4

fentanyl [18] 30:3 135:13,14,

19 138:8,14 182:1 185:3 197:16 321:7,11,18,19 323:1,3,6,

8 347:22

fentanyl-based [1] 197:15

ferret [1] 338:16fetal [25] 19:20 25:11 26:8,19,20 71:2,13 76:21 77:7 93:17

99:9 103:19 104:4 105:1,20

192:15 194:19 195:1 196:1,6

208:20 259:6 269:14 279:9

350:10

fetus [18] 21:5,15 24:22 25:20

35:15 63:4 94:7,7 95:7 105:4,

16 185:13 192:15 257:5,17

279:6 351:2,20

fetuses [8] 62:16,21 108:18113:1 171:10 185:14 186:10

352:7

few [16] 82:1 95:15,16 99:7

109:10 128:19 173:11 206:4

268:20 275:21 316:20 323:5

347:17 351:16 355:10 358:

15

fibrosis [1] 82:2

field [3] 94:12 116:12 146:6

fields [1] 225:14

fifth [1] 295:4

fifties [1] 184:2

figure [4] 42:22 43:1 127:10

337:20

figured [1] 161:3

figuring [1] 125:8

fill [1] 179:6filling [1] 52:17

final [4] 106:18 111:15 113:13333:5

finally [11] 83:18 90:15 96:15

98:10 133:21 191:13 224:9

238:2 244:10 247:3 261:11financial [12] 9:12 10:6,12218:17,20 219:4,7 220:4 224:

20 234:19 250:5 256:10

find [18] 78:13 88:1,5 95:22

125:19 126:13,17 138:5 181:

5 209:9 258:17 262:3 270:22

289:4,17 338:22 343:6 359:

21

finding [8] 36:19 73:16 130:

22 138:18 210:5 249:10 314:

9 327:21

Findings [44] 3:25 11:11 12:

17 14:2,19,21 15:11 24:18

25:4,10 40:5 41:21 46:7,9,10,

14 47:18 52:15 55:9 56:1957:21 59:4,7,21 60:17 61:16

62:20 63:10,22 64:3,16 65:

10 66:10 96:22 183:2,4 186:

16 268:18 297:13 301:10

310:11,22 312:20 343:9

finds [1] 332:22

fine [4] 117:15 211:8 333:16

352:12

finesse [1] 349:13

finish [2] 174:15 181:12

firm [1] 10:13

firms [2] 9:14 10:5

first [58] 5:5 10:15 22:16 24:

22 25:8,18 29:5 33:2 42:1 44:6 48:18 53:3 54:20 55:4 59:5

72:18 76:5,9 78:18 83:5 98:8

99:8 100:1 110:18 111:21

112:12 142:11 144:7 157:4

176:9,11 178:13 187:21 208:

1 219:18 220:14 229:8 230:

15 237:7,7,14,15 238:13 256:

9 257:8 261:14 270:8 283:15

309:9 310:9 311:10 316:15

325:1 328:4 342:5 343:22

347:8,11

fishing [1] 347:8

fits [2] 234:1 326:17

fitting [1] 155:5

five [5] 10:19 24:16 162:14273:19 365:6

fixed [2] 337:8,9

flashing [1] 84:18

flip [1] 316:2

floor [1] 233:2

Florida [1] 247:18

flow [6] 121:8,13,16 122:1

166:21 216:17

flows [1] 121:20

fluid [1] 251:2

Fluoro-Jade [4] 167:6 173:6

175:13,21

experiments - Fluoro-Jade



focus [18] 13:5 16:16 46:20

49:18 50:4 52:5 53:3 110:8

229:9 230:4,6,7 242:9 260:9

261:7 289:15 319:20 320:15

focused [2] 51:15 283:3

focusing [12] 41:14 48:12 50:

4,8,19 51:2 52:10,16 85:7

110:9 111:4 146:19

fold [6] 122:13,21 131:2 138:6

264:8 268:20

folks[1]

264:11follow [13] 10:18 17:16 30:1

120:7 165:14 205:20 212:7

234:21 275:12 285:5 316:8

353:16 355:6

follow-up [3] 317:12 348:2,8

followed [7] 91:11 99:19 119:

3 125:16 132:8 166:15 285:7

following [16] 9:4 14:9 23:9

34:10 39:5 77:11 80:10,20

81:4,21 87:15 90:6 218:5

222:13 247:2 280:19

Fontan [1] 332:10

FOOD [5] 1:2 28:9,11 31:12

218:7

forces [1] 240:19forefront [2] 331:2,6Forest [1] 6:11forgive [1] 42:4

form [8] 111:16 113:14 116:8

169:16 223:21 238:10,20

243:1

formal [3] 310:19,20 332:17formation [6] 111:4,10 112:

14 115:4,10 234:1

formed [2] 111:18 200:11

forms [2] 27:3 245:8

formula [1] 250:22

formulated [1] 240:6

fortunate[5]

13:7 42:6 52:13185:10 290:22

forum [1] 219:9

forward [5] 14:16 100:6 308:

21 312:19 325:7

found [57] 28:18 35:17 75:22

76:15 77:2 82:16,21 83:2 86:

7 87:19 89:8,13 107:13 118:

18,20 119:1,5 121:22 122:8

127:2 128:8 130:17,22 138:

17 140:7,10 141:18,21 144:

16 164:2 185:4,13 188:16

189:1 235:10 236:5,12,17

237:7,16,20 238:2,8,12,22

247:6,19 267:17,18 268:15

272:17 273:7 275:6 282:3299:11,19 316:18

Foundation [1] 256:12

founder [1] 228:22

four [8] 20:18 22:6 148:16

162:14 225:22 295:17 338:

22 339:6

four-fold [1] 332:11

fourth [1] 124:13

fraction [1] 191:9

fractures [2] 188:13 322:18

fragment [1] 18:12fragmentated [1] 174:7

fragmentation [1] 129:11

fragmented [1] 79:4

frame [7] 17:6 49:4,13 92:19,

19 93:2,15

Framingham [1] 282:14

Frances [1] 28:21

Francisco [1] 248:8

frank [3] 105:12,14 306:1

Franks [2] 117:10 294:18

Fredriksson [2] 61:6 69:18

free[1]

253:11frequently [8] 39:5 144:13

184:8 188:11 195:17 197:2

323:12 334:12

friendly [1] 224:1

friends [2] 37:4 182:8

front [2] 70:19 179:10frontal [7] 95:9 153:18 156:14,22 171:22 276:8 278:7

frontotemporal [1] 349:2full [4] 99:18 221:19 224:8335:19

full-term [1] 275:5

fully [16] 35:1,9 37:7 73:21 86:

16 88:2 110:12 112:21 140:5,

17 202:19 206:17 214:18288:16 289:22 321:17

function [16] 17:13 55:13

154:16 157:16 158:11,22

159:5 165:12 177:5 180:6

240:9,21 276:13 290:14 291:

8 349:11

functional [10] 62:9 125:4148:12,18 180:4 186:22 187:

6 198:7 268:3,6

functioning [1] 161:13

functions [3] 110:6 149:4

241:1

Fund [1] 256:14

fundamental[1]

271:5funded [3] 47:21 201:9 325:

16

funding [3] 199:7 202:17 329:

20

funds [1] 47:3

further [30] 11:12 12:4 14:17

22:5 36:1,4 40:13 41:20 45:4

46:18 47:7 51:4 59:2 70:14

89:6,11 106:10 107:8 151:1

153:14 163:15 185:22 202:4

206:22 232:22 236:12,17

267:22 333:16 334:9

Furthermore [4] 184:6 189:4

193:16 194:20

future [13] 180:13 228:21 260:9 266:2 270:10 292:21 293:4

319:22 320:9,13 337:16 352:

9 356:19

futuristic [1] 74:14

GGABA [15] 17:19 19:12 39:10

71:10 76:13 116:1,5,17,21

117:4,16 181:21 210:8 297:

16 321:12

GABA-A [3] 76:13,14,18

GABA-ergic [11] 18:1,18 66:

21 106:8 209:19 210:12 229:

11,21 233:11,12 295:2

GABA-ergic-agonist [1]

296:10

GABA-mimetic [4] 19:4 76:

20 82:20 84:3

GABA-mimetics [1] 83:21

GABAA [1] 82:17

gaining [1] 248:3

Galveston [1] 8:13

games [1] 291:7

gamma[1]

238:16gamma-aminobutyric [1]

17:18

gamma-secretase [1] 237:

22

gas [12] 83:15 90:4 117:9 120:

5 137:8 257:11 284:20 287:1

320:17 343:22 344:17 362:

18

gases [1] 57:9

Gate [2] 240:5 249:19

gathering [1] 218:9

gauge [1] 331:3

gave [11] 29:1 31:14 73:1 150:

13,14,17,21 171:11,12 188:

21 190:2gazillion [1] 336:22

gender [8] 31:1 32:4 37:20

73:13,16 323:18,21 329:4

genders [1] 31:3

gene [4] 107:12,12 318:6 328:

10

General [37] 4:9 9:22 11:1512:19 21:18 22:6 83:22 108:

6 110:1 116:14,15 145:9,18

163:8 201:1 225:8,10 230:18

245:15 246:4,22 247:7,12

260:22 261:16 262:3 263:15

266:19 288:8 295:2 309:8

325:8 327:11 336:18 349:19350:17 356:1

generally [10] 20:18,19 21:16

24:17 32:22 33:14 35:2,10

241:22 270:22

generate [1] 162:8

generated [1] 241:13

generation [13] 226:11 233:

19 237:11,14,19 238:1,11,18,

19,21 239:8,9 241:8

generic [1] 24:5

generous [1] 114:8

genes [4] 107:7 260:7 314:6

360:9

genetic [3] 195:19 197:1 293:

22genetics [1] 294:1

genome [2] 240:20 293:10

genomic [4] 166:2 293:1 301:

7 328:9

gestation [9] 17:4 49:9 93:20,

21,22 164:14 215:11 269:8

353:14

gestational [7] 63:8 66:2 166:9 170:4 175:17 178:10 352:

18

gets [6] 87:5 253:15 297:6

322:22 339:3 351:14

getting [13] 155:13 162:11

172:3 174:12 192:20 204:1

207:18 221:6 253:21 286:4

320:11 350:15 361:14

GI [1] 72:4girl [1] 220:10give [21] 54:8 68:12 74:18 89:

18 109:16 112:4 123:10 133:

12 138:9 160:4,14 176:4 178:

14 183:13 202:10 206:11

211:20 307:9,9 342:13 353:18

given [15] 32:13 88:3 149:22

153:3 166:17 171:15 188:8,

15 317:17 340:5 341:15 349:

20 353:19 356:4 364:3

gives [6] 107:14 123:21 159:8

160:1 175:10 234:7

giving [9] 10:19 99:18 151:15

158:16 189:8 190:17 325:4,4

342:12

Glasgow [1] 200:17

glass [1] 103:21

glial [3] 82:3 111:5,10glucose [7] 91:20 92:6,9 137:

8 168:3,5 257:11glutamate [8] 17:18 75:18 82:

17 115:22 116:6,19,21 117:

16

glutamatergic [2] 229:11,21

glutaminergic [1] 18:2

glycol [4] 28:6 83:8 84:7,11goal [2] 216:15 222:8gold [1] 78:9

Golden [1] 249:19

Goldilocks [1] 249:4

gosh [2] 250:7 251:22

got [14] 135:6 137:15 150:15152:8 155:11 206:10 211:22

212:18 253:16 266:1 302:20304:18 325:12 356:22

gotten [1] 365:9

govern [2] 240:10 241:10

government [2] 12:7 325:10governs [1] 241:3

gradients [1] 106:1

graft [1] 247:14Grail [1] 298:7grams [4] 110:17 120:22 133:

1,4

grandson [1] 228:21

grant [2] 95:1 256:12granted [3] 26:2,6 33:17

grants [1] 201:10

graph [1] 340:10graphs [1] 340:2

grapple [1] 207:8

grasp [1] 211:17

grateful [1] 15:21gratitude [1] 202:10

gray [2] 274:17 275:7

great [6] 126:9 137:1 167:9197:13 256:4 357:6

greater [11] 25:5 29:4 53:2

62:7 64:12 162:5 176:7 234:

14 242:18 316:19 317:7

greatest [3] 164:7 235:3 349:

focus - greatest



5

green [2] 219:11 316:10

Greg [1] 260:19

Gregory [1] 4:18

gross [1] 65:6

ground [1] 148:3

groundbreaking [1] 149:8

group [59] 23:22 44:19 46:8

49:3 59:4 63:11 143:22 147:

7 183:7 184:21 185:4,11,22

186:14 187:2,19 188:5 191:22,22 192:2 193:1,13 194:18,

20 196:1 198:19 199:15 200:

12 202:11 207:1 230:8 231:6

233:10 234:9 246:2 247:6,17

253:8 254:5 257:2 261:19

262:14 264:5,16 271:21 274:

2 294:18 314:20 320:9 326:

11 343:17 344:2,2,14 346:1

350:5 359:15 363:11 364:12

Groupe [5] 2:3 3:5 6:17,17 9:

4

groups [11] 78:6 80:16 81:6

103:2,4 191:21 199:7 258:8

264:10 299:2 347:2

grow [2] 153:21 277:19growing [10] 17:15 27:15 40:

4 66:14 67:20 221:11 225:1

245:3 277:20 285:11

grown [1] 34:5

growth [8] 17:3 76:1 110:15,

18,20 111:1,2,8

Grunau [1] 317:2

guess [6] 270:9,10 280:8 307:

7 308:12 326:9

GUEST [1] 2:26

guests [1] 11:3

Guidance [4] 33:10 310:7

318:2 334:22

guide[2]

161:15 350:22guideline [2] 31:2,4

guidelines [3] 24:5 30:19 33:

15

guides [1] 240:2

guiding [1] 293:18

guinea [19] 67:8 101:11 112:

7,18 113:1,7 134:4,6,21 136:

1,3,8,18,19 140:5 214:2 315:

5 321:16,20

guy [1] 253:8

guys [1] 256:4

Guzman [2] 2:10 3:26

H

H4 [1] 237:10Haberny [1] 46:4

half [5] 134:11 136:3 150:14

167:12 269:2

hallmarks [2] 111:3 114:16

halogenated [1] 251:3

halothane [11] 28:15 144:15

231:11 233:8,8,12,19,21 234:

1 296:18 320:2

Hamlet [1] 183:17

hand [5] 39:20 214:18 292:11

306:19 311:7

handed [1] 44:7

handle [3] 151:9 179:7 363:

21

handouts [1] 6:22

hands [6] 202:2 210:9 309:13

310:1,3 338:22

hanging [1] 338:8

haphazard [1] 351:8

haplotypes [1] 293:3

happen [7] 98:13 111:20 112:

15 114:17 115:2 135:9 286:

21

happened[5]

130:14 133:8150:7 179:15 274:6

happening [6] 104:21 108:9

111:20 250:16 266:10 285:

12

happens [18] 36:18 37:13 92:

18 93:1 110:21 112:11 113:

11 116:3,8 118:21 123:20

139:7 140:5 207:19 236:21

314:8 356:8 358:3

happily [1] 211:22

happy [7] 127:15,17 135:3

224:8 243:9 275:2 341:22

harbinger [1] 230:22

hard [4] 120:7 141:4 182:7

225:14harder [2] 215:15 253:20

hardly [1] 234:7

harm [5] 25:11,14 245:4 302:

9 306:16

harmful [3] 194:15 244:15317:16

harming [1] 202:19

Hartman [1] 125:15

Harvard [4] 4:9,18 7:15 257:3

hate [1] 126:8

Hayashi [3] 53:4 60:15 188:5HBA [1] 317:9

head [3] 254:5 292:12 301:14

head-to-head[1]

273:2headed [1] 200:14

heads [1] 365:2

HEALTH [9] 1:1 8:17,19 22:1

30:9 47:9 97:1 265:7,10

healthy [8] 145:10 253:14

273:16 286:11 287:2 344:4

347:18 362:19

hear [2] 63:13 280:15

heard [23] 110:12 111:19 113:

15 114:2,15 117:5 167:4 181:

19 213:2 228:16 261:6 262:

18 263:18 265:21 307:2 308:

22 310:14 324:12 356:11

359:18 362:17 363:17 364:

12HEARING [14] 4:2 14:12,16

50:11 89:17 218:2,4,6,10,15

250:14 266:15,17,18

heart [4] 109:20 134:14 137:11 332:6

heart-defect [1] 331:9

heavily [1] 39:3

heck [1] 255:2

Heights [2] 4:4 220:9

hell [1] 254:2Hello [1] 6:17

help [22] 46:18 72:14 125:14

142:4 155:22 163:15 180:12

200:6 204:6 243:7 268:7 277:

8 289:21 315:3 318:4 319:6

328:9,14 349:8 354:12 361:2

362:4

helped [2] 28:9 58:4

helpful [7] 39:20 289:18 290:4 293:4,18 310:7 321:5

helping [2] 161:14 199:17

hemodynamic [2] 57:10 307:

22hemoglobin [2] 100:11 168:

9

hemorrhage [1] 273:6

hemorrhages [1] 185:8

hemostasis [1] 133:11

Henthorn [10] 2:8 6:7,7 70:

21,22 288:20 312:11 315:20

329:11 336:17

Henthorn's [1] 287:22

hepatic [1] 110:5

hernia [3] 286:12 344:5 362:

20

hernias [1] 200:20

herniorrhaphies [1] 287:3

herself [1] 224:2hesitate [1] 229:18

Hickey [1] 185:12

hidden [1] 245:4

high [32] 85:4,20 86:2 109:20

185:3 190:17 206:2 221:22

222:8 226:4 227:6 244:17

260:2 272:17,19 273:19 295:

19 318:12 326:7 329:21 330:

11 332:2 335:16 336:5 352:3

353:20 354:2 355:4,19 360:

13,14 364:19

higher [20] 60:20 61:2 64:2

81:7 87:15 94:11 130:18 171:

7,17 206:9,20 207:20 214:14,15,21 228:14,17 233:22 264:

8 330:6

highest [5] 190:18 195:13

214:12 257:9 344:15

highlight [1] 54:8

highlights [2] 52:11,17

highly [4] 81:5 93:8 226:5,13

hint [1] 65:15

hippocampal [4] 54:18 55:13 267:22 268:12

hippocampus [5] 95:20 257:

22 267:8,18 268:20

histological [4] 124:19 167:2171:2 268:18

Histologically [1] 209:8histology [1] 354:17

histomorphological [1] 114:16

histopathological [2] 11:19361:22

histopathologically [1] 50:

14

histopathology [3] 53:9 54:

15 59:11

historical [2] 41:19 345:2History [9] 3:12 13:16 41:5,7

234:11 273:11 302:20,20

322:6

hit [3] 165:3,5 278:20

hit-and-miss [1] 37:9

hitting [1] 352:3

HIV [1] 276:18

hockey [1] 278:20

hold [2] 182:18 205:6

holding [1] 74:15

Holtz [1] 8:8

Holy [1] 298:7

home[2]

142:22 297:8homeostasis [1] 146:5

Honorable [1] 219:19

hope [3] 146:13 261:9 356:19

hopefully [2] 200:5 254:15

Hopkins [1] 6:5

hormones [1] 186:6

horrendous [1] 358:1

horribly [1] 326:21

Hospital [9] 4:9,19 7:15,20 8:8 185:11 197:12 306:2 348:7

hospitals [1] 200:18

Hotel [1] 1:8hour [13] 78:20 89:11 91:11,

21,21 92:3 126:1 144:12 151:

22 153:4 166:20 203:17 340:8

hours [119] 53:9 55:10 59:12

65:1,2 66:5 80:10 81:18 88:

22 89:2,7 91:19,21,22 92:4,5,

17 94:5,6 95:3,6,6 105:18

120:5,6 121:19 122:8 125:18

129:21,22 130:12,18 131:1,8,

8,9 132:2,3,9,11,11 133:7

135:20 136:12 138:15 139:4

152:1,5,5,8,11 153:4,4,5,7

154:20,21,22 159:6,12,14,19,

21 160:17,20 165:1,1,2 166:

14,14 169:5,6 171:10,12,13,

16 172:5,17 173:14,15,17174:21 176:3,4 178:17,18

179:3 188:19,21 189:9 203:

15 204:2,15,15 206:12 216:5

236:7 257:12,15,15,15,21

258:3,3 259:5,6,7,8,11 272:

10 283:19 284:19 286:14

340:8 350:8 352:5 354:3 361:

18 364:11

hours-plus [1] 216:9

however [31] 10:18 25:6 34:

22 35:7 47:22 51:6 57:12 66:

12 77:13 78:13 102:14 112:8

115:7 122:6 127:21 173:13

175:22 187:2 188:20 190:14

192:9 202:3 209:20 216:6233:4 239:15 246:5 258:21

268:18 282:6 299:18

Huafeng [1] 4:16

Huda [1] 314:2

huge [3] 191:11 225:1 356:6

HUMAN [53] 1:1 12:20 20:11

25:5 26:8 30:9 47:8 48:20 49:

4 73:2 76:6,22 83:11 92:20,

22,22 97:3,6 101:14 102:5,6,

8 104:3,7 110:19 111:7 162:

21 163:5,17 169:22 184:9

186:9,17 187:19 189:5,7 192:

greatest - HUMAN



9 206:21 207:5,21 215:7 240:

20 241:15 269:5 276:2 282:

14 294:6 310:18 314:15,17

315:6 316:5 318:12

humane [1] 201:16

humans [37] 17:6 25:13,21

26:5,10,18 55:19 56:14 57:

17 58:14 69:3 101:10,20 110:

11 112:7,11 133:16 146:16

191:4 193:5 199:21 202:3

211:7,10 212:11 214:2,4 269:17 292:14 310:12 311:1 312:

20 313:4,9 318:10 328:12,19

humbly [1] 69:14

hump [1] 254:17

hundreds [1] 226:8

hurdle [2] 254:14 364:19

hurt [3] 308:17,19,19husband [1] 220:16

hybridization [1] 174:18

hydrate [1] 23:5

hydromorphone [1] 228:2

hyperactivity [1] 105:22

hypercarbia [2] 302:13 304:

1

hypercarbic [1] 120:10hypercardia [1] 242:20

hyperglycemia [1] 185:5

hyperperfusion [1] 121:14

hypertensive [1] 253:15

hypertrophy [1] 82:3

hyperventilation [1] 184:15

hypervolemia [1] 121:15

hypnotic [4] 19:13 22:7 242:

16 247:20

hypnotic-agent [1] 242:18hypnotics [1] 34:16

hypocapnia [2] 235:22 239:6

hypocarbia [1] 120:3

hypocarbic[2]

119:21 120:10

hypoglycemia [5] 91:4,7,14,

15 92:11

hypoglycemic [1] 91:8

hypotension [1] 185:8

hypothermia [3] 291:16 329:

16,18

hypothermic [2] 291:20,20

hypotheses [1] 349:9

hypothesis [7] 92:16 162:7

234:2 242:12 257:8,20 273:4

hypothesize [1] 241:7

hypothesized [1] 257:3

hypothesizing [1] 230:10

hypoventilated [1] 119:22hypoxia [5] 120:3 235:22 239:

6 302:12 304:1

hypoxia/ischemia [5] 89:21

90:3,14,16 91:7

hypoxic [3] 119:21 120:9 301:

19

IICU [15] 22:20 189:11 271:11,

22 286:16 308:8,9 317:5 323:

13 334:1 346:18 347:4,13

348:7 362:21

idea [23] 107:6 109:16 112:4

137:19 143:3 150:21 153:1

158:20 160:1 162:12,15 163:

12 164:20 167:11 176:17

177:3 179:14 181:22 288:16

293:18 294:4 300:5 342:4

ideal [1] 304:4identified [8] 33:18,20 40:2

49:2,2 79:12,15 107:13

identify [12] 33:22 34:8 38:16

56:5 80:6 98:15 270:19 306:

19 325:10 346:14 362:7,13identifying [3] 78:10 290:4

347:11

ignore [3] 211:19 212:11 324:

9

II [2] 5:13 166:4III [3] 2:10 3:26 165:21Ikonomidou [5] 11:4 42:3 59:

8 60:15 209:5

Ikonomidou's [1] 53:4

ill [3] 286:15 303:13 352:7Illinois [2] 4:4 220:9

illustrate [2] 52:22 97:22

illustrates [2] 43:4 55:17

illustrating [1] 98:7

IM [2] 135:22 166:18imaged [1] 275:5

imaging [12] 165:19 274:2,19

290:4 349:3 359:22,22 360:7,

17,21 361:6,6

immature [2] 97:3 193:17

immaturity [1] 110:5

immediate [7] 227:9,12,14,

21 228:8,10 337:16

immediate-release [1] 228:

13

immediately [3] 91:18 159:

17 160:3

immunocytochemistry [1]

80:20immunohistochemical [1]

80:5

immunohistochemistry [1]

80:13

immunosuppression [1]

323:15

impact [15] 14:1 15:3 17:12

44:9 56:20 225:3 229:4 235:

5 244:5 248:21 269:10 316:4,

22 349:4,5

impairment [6] 144:9 262:5,

11 264:19 265:4,22

impairments [4] 19:22 55:14

144:17 145:17

Implement [1] 223:13Implementation [1] 30:1

implicated [6] 55:2 66:20,21,

22 67:4 231:16

implication [1] 183:8

Implications [10] 3:24 16:14

47:17 57:21 83:10 97:1 140:

21 183:2,3 193:3

importance [8] 42:15 74:13

154:12 174:16 221:16 326:1

328:2 350:4

important [78] 13:10,22 15:10 23:7 30:15 48:22 53:16,

22 54:4,9 59:16 61:16 68:5

74:9,21 75:7 80:1 96:22 102:

4 115:13 116:1,4 117:16 131:

13 148:10 153:10 154:11

155:6,7 189:17 199:19 200:

11 201:18,20 204:9 205:4

208:3 209:19 211:7,10 212:

13 213:18 218:12 221:14

233:9 235:13,16 245:10 247:

22 248:1,14 249:7 252:8,20

261:5 267:13 275:13 283:15285:13 287:14 290:9 297:9

302:18 305:1,6 308:3 309:14

318:6 319:17 322:7 325:10

327:9 331:21 332:22 334:1

348:5,8 354:13

importantly [3] 118:8 187:5

190:5

impress [1] 141:1

impressed [2] 251:17 337:21

impression [1] 145:3

impressively [1] 140:9

improve [1] 208:11

improved [4] 32:6 227:7 258:

21 259:9

improvement [2] 107:15 259:2

improvements [1] 243:1

improving [1] 249:10

impulses [1] 193:17

impulsivity [1] 316:20

in-situ [1] 174:17

in-utero [5] 112:12,19 113:3,

9 134:8

in-vitro [1] 160:14

inactivate [1] 97:18

inadvertent [1] 228:17incidence [9] 38:3 64:6 244:

17 247:7 262:4 264:11 272:

17,20 316:20incision [1] 190:12

include [8] 22:8 30:22 47:15

83:13 137:17 218:21 248:19

290:15

included [7] 54:15 88:12 119:

16 139:21 198:18 221:1 328:

4

includes [2] 28:1 290:13

including [12] 11:5 19:21 29:

15 45:9 185:6 186:17 193:12

215:7 240:19 254:20 271:4

338:17

inclusive [1] 22:20

incompatible [1] 205:17

inconceivable [1] 108:9incorporate [2] 307:4 364:7

increase [52] 64:2,5,10,12 85:

22 86:12,15 87:2 89:4,6,9,13

92:9 103:22 122:13,21 129:

15 130:8 131:3 138:6,7,13

150:9,16,18 154:7,9 155:10,

11 157:7 171:19 172:11 173:

2,15 175:1,17 176:2,5 177:15

188:17 235:5,8 236:12,16

237:5 238:15,15,18 247:21

268:20 321:18 357:18

increased [16] 18:19 50:17

77:18 79:18 89:11 109:1,1

171:16 173:14 174:20 188:

18 199:4 241:18 246:4 247:

13 259:17

increases [4] 25:6 207:4 236:

11 332:11

increasing [6] 22:4 221:17

235:15 246:6 248:3 263:2

incredibly [4] 125:1 135:15

211:2,7

incremental[1]

290:7incremented [1] 216:11

indeed [25] 46:9 51:19 75:13

129:21 139:20 149:21 174:2

185:14 186:8 187:3 189:18

195:12 196:21 199:22 202:

16,19 213:18 214:20 216:1

231:2,15 265:3 282:3 343:13

344:8

independent [2] 143:12 237:13

independently [1] 84:15

indicate [4] 93:13 169:12 240:

22 285:15

indicated [3] 50:11 186:5

187:22indicates [2] 19:3 80:2

indicating [1] 237:11

indication [5] 22:3 33:17 34:

4 173:7 350:7

indications [6] 13:18 23:13

32:21 210:21 247:16 351:10

indicative [3] 43:21 158:5

299:15

indicator [5] 167:3 172:12,15

173:7 356:15

indicators [1] 290:2

indirect [1] 197:8

individual [12] 14:7 18:10 22:

1 67:16 77:14 88:11 89:2215:21 223:8 322:22 335:18

341:20

individual's [1] 218:13

individually [4] 63:16 87:19

297:18 300:20

individuals [5] 45:13 125:1

362:8,13,14

induce [19] 86:10 90:17 104:

1 106:17 160:16 207:16 236:

8,15,18,20 237:9 238:13 239:

8 253:5 255:15 257:4,21 260:

3,6

induced [5] 14:2 186:21 187:

4 237:5,12

induces [1] 90:2inducing [1] 19:15

induction [7] 141:15 143:8

174:19 175:1 188:9 250:3

326:20

Industry [7] 2:14 8:22 9:19,

20,22 33:11 99:2

ineffective [1] 26:16

infancy [1] 316:9

infant [17] 21:2 77:10 80:10

86:13,19 88:3,15 90:17 91:6,

17 92:12 153:20 194:8 273:

16 279:10 331:10 347:16

HUMAN - infant



infants [15] 35:21 47:18 186:

1 187:17 197:12 198:5 200:

21 279:19 283:17 287:2 307:

18 344:4 361:17,18,21

infarctive [2] 277:2,2

infected [1] 276:19

inference [1] 347:3

inflammation [1] 18:13

inflammatory [1] 115:16

influence [5] 17:17 245:12

248:10 291:21 294:1influx [2] 161:17 176:20

inform [1] 248:14

information [41] 13:21 15:18

19:2 20:16 23:12,18 24:10

27:11 36:1 39:19 49:20 52:

12 53:1 65:13 66:8,14 67:8,9,

18,20 68:2,8,13 69:10 72:17

153:10,15 158:17 218:9,20

252:22 261:12 262:19 266:5

274:11 308:2,21 309:16 311:

12 341:18 365:10

informed [1] 29:15

informing [1] 24:1

infused [3] 95:3 166:12 216:

10infusion [14] 94:3,4 99:10,14

135:13,19 138:14 166:18

188:22 212:22 321:19 340:

19,20 347:21

infusions [8] 197:16 271:11,

12,14 272:17,21 332:1 340:

16

ingredient [1] 88:13

inguinal [3] 200:20 286:12287:2

inhalation [2] 236:3,17

inhalational [6] 117:3,11 213:10 250:9,18 253:1

inhaled[17]

19:14 22:7 34:17194:4 213:13 229:10 230:10,

17 257:4 318:18,19,20,20

320:7 324:14 328:21 355:20

inherent [1] 260:4inhibit [1] 116:21

inhibited [3] 98:4 100:20 258:

2

inhibition [1] 116:21

inhibitor [1] 107:14

inhibitors [1] 237:17

inhibits [2] 242:1 259:5

initial [11] 39:5 57:22 127:4148:5 163:20 178:14 181:8

247:2 268:18,19 272:14

initially [5] 57:16 85:3 146:1166:17 233:11

initiated [3] 12:7 29:22 248:9

initiating [1] 348:17

Initiative [1] 183:8

initiatives [2] 198:12,18

inject [1] 284:5

injecting [1] 284:7

injection [3] 53:10,11 340:4

injections [8] 42:19 44:4 53:

8 59:11 340:5,6,15,22

injury [7] 68:20 107:11 193:

20 195:22 197:6 324:2 359:9

input [4] 33:13 45:15 341:12365:11

inquest [1] 220:20

inside [3] 126:12 171:8 338:5

insights [1] 69:12

insistent [1] 219:15

insofar [1] 222:14

instability [1] 196:7

instance [1] 43:22

instances [1] 20:22

institute[1]

291:15institution [4] 186:1 197:11

200:16 352:1

institutions [3] 201:11 272:3

360:20

instructive [1] 356:18

insults [3] 51:7 239:6 357:2

intact [1] 115:6

integrated [1] 301:10

integration [2] 276:14 349:

10

Intelligence [2] 345:22 348:

12

intensive [4] 16:21 197:4

213:3 291:15

intensive-care [2] 135:17212:20

intensivist [2] 7:19 271:10

intensivists [1] 287:8

intentionally [1] 90:17

interact [3] 106:15 233:1 336:

15

interacted [1] 98:3

interaction [3] 227:1 246:15

337:13

interactions [3] 181:21 242:

16 336:11

interagency [1] 47:6

intercellular [1] 98:20

intercept[1]

97:18Interest [13] 3:4 9:2,3,5,16 10:

7,11 84:7 147:1 182:17 239:

21 292:12 294:11

interested [11] 102:16 156:

16 165:18 260:21 265:13

277:6 307:3 314:9 318:2 359:

5 361:12

interesting [36] 19:17 32:18

42:7 51:17 61:9 62:21 69:19

73:19 134:6 141:19 145:1

150:11 151:16 152:14 170:

12 172:8,10,21 174:1,21 179:

22 206:15 214:11 215:10

251:21 252:14 269:13 288:

17 289:6 292:19 294:14 350:20 351:4 353:9 355:6 358:14

interestingly [4] 61:22 64:4

138:8 246:19

interests [4] 9:12,14,22 220:

4

interfere [4] 75:6 97:17 98:20

241:20

interim [1] 277:7

intermittent [1] 347:21

intermixing [2] 79:5 115:9

internal [3] 78:18 190:12 253:17

international [2] 200:10 322:3

internist [1] 225:10

interpret [8] 58:3 59:3 68:172:15,16 206:13 301:12 342:

8

interpretation [2] 56:21 163:

16

interpretations [1] 68:12

interpreted [3] 24:6 46:22 58:

17interpreting [1] 153:12

interrogate [1] 301:9

interval [1] 204:1intervals [3] 151:14 241:9

277:20

intervening [1] 332:12

intervention [3] 68:22 144:6

364:4

interventions [4] 21:21 144:

3 273:13 287:8

intoxication [1] 86:4

intracellular [2] 97:19 98:5

intraoperative [1] 271:20

intraperitoneal [1] 53:8

intraperitoneally [1] 88:3intravenous [9] 36:1 117:3

134:17 190:17 250:17 251:8

253:6 255:16 256:2

intravenously [2] 95:3 166:

12

intraventricular [2] 185:8

273:6

intrigued [1] 288:22

intrinsic [4] 79:15 128:22

129:1 298:22

introduce [2] 5:6 84:19

introduced [1] 28:16

introducing [1] 167:10

introduction[1]

219:19Introductions [2] 3:2 5:2

Introductory [2] 3:7 10:22

intubate [1] 134:14

intubated [5] 252:16,18 271:

15 273:19 347:17

intubating [1] 190:10

intubation [1] 273:17

invest [1] 357:14investigated [2] 202:4 325:

14

investigation [1] 326:4

investigational [3] 26:9,2129:14

investigations [2] 45:19 293:

2investigator [2] 260:20 345:

4

investigators [11] 13:7 14:8

52:14,20 68:10 73:18 193:19

208:2 291:14 325:15 358:18

investment [2] 333:1 357:4

invited [2] 9:18 11:2

inviting [2] 74:8 183:7

involve [3] 50:10 177:22 246:

9

involved [17] 39:9 45:2,13 54:

6 80:16 149:16,16 158:12

160:22 193:21 195:7 199:16

216:8 221:6 225:9,12 240:16

involvement [2] 10:8,12involves [4] 10:4 148:11 241:

15 363:8

involving [3] 9:10 78:6 247:9

IP [1] 342:12

IQ [2] 104:15 348:10

irrefutable [1] 201:22

irrelevant [1] 213:22

ischemia[7]

51:16,22 259:16260:5,6 324:2,16

isn't [3] 103:17 204:4 320:1

isobole [1] 337:8

isobolographic [1] 337:4

isoflurane [76] 19:10 30:17

54:14,21 88:10,12,15,17 89:3

90:11 91:6,9,11,13 92:2,3,4,

4,8 118:12 136:2 137:17,19

138:7,19 213:4,16 214:2,3

231:12 233:5,5,12 235:1 236:

3,6,15,18,20 237:6,8,12,18,

20 238:12,22 239:2,16 251:1

257:1,4,10,16,20 258:1,4,19,

21 259:4,8,11,14,18 260:11,

14 263:1 284:19 294:21 296:14,15 297:12 298:3 318:18

320:2,16 335:15

isoflurane's [1] 233:13

isoflurane-induced [5] 236:

13 238:6,9 256:16,19

isolated [7] 202:12 230:15

316:13 341:13 342:3,6 347:

15

isolation [1] 334:16

Israel [1] 64:16issue [51] 9:5 39:20 72:4 84:

19 106:9 107:5 121:4 180:13

183:12 189:4 191:13 193:8,

20 194:1 199:19 200:1 202:12 204:10 219:6 224:6 244:

12 261:20 268:1,2,3 269:13

272:4 275:13,19 279:3,6 294:

18 320:18 323:3 324:13 325:

8 326:4 328:2 330:9 331:19,

21 332:4 334:18 335:3 336:

15 338:6 344:15 356:13 357:

17 362:12 365:7

issued [4] 30:19 31:1 33:12

223:9

Issues [20] 3:9 16:4,7,17 149:

10 156:20 181:2 225:8,13

244:13 256:2,5 265:8 285:7

289:9 302:13 304:7 327:8

338:16 359:17item [1] 9:1

items [1] 287:17

itself [11] 50:14 59:1 69:8 141:

17 148:16 160:19 190:7 197:

3 231:4 336:3 363:7

IV [3] 33:6 165:21 253:3

JJackson [5] 4:3 219:18,21,22

220:6

James [1] 2:7

Jane [1] 345:22

January [1] 38:15

infants - January



Japan [1] 117:12

jar [1] 133:6

Jayant [2] 2:18 7:5

JCAH [1] 331:3

Jeff [1] 8:15

Jeffrey [1] 2:20

Jevtovic-Todorovic [27] 2:

19 3:19 6:13 108:4 209:3

214:7 267:14 269:12 283:11,

13 295:6,10,14 297:19 299:5

300:16 301:14 302:5 312:8313:20 321:9 326:18 338:19

351:12 353:22 354:6,11

Jevtovik-Todorovic [1] 74:

15

Jim [2] 6:10 337:2

job [1] 167:9

John [17] 2:27 3:16 4:13 11:5

42:5 74:3 101:21 149:8 165:

4 172:2 181:2 203:12 205:12,

17 247:5 249:16 304:13

Johns [1] 6:5

join [1] 185:10

joined [1] 16:11

joining [2] 6:20 48:3

Journal [5] 185:17 198:21199:6 306:11 314:3

journals [1] 282:7

Jr [2] 2:31 3:23

judge [1] 203:18

Julia [1] 2:22

Julie [1] 8:2

jump [4] 87:3 102:7 152:9

154:9

jumps [1] 170:15

juvenile [10] 11:7 12:8,15 14:

3 19:8 33:7 211:11 258:16

259:10 261:7

juveniles [2] 11:21 258:22

KKanwaljeet [2] 2:6 6:20

keen [1] 346:16

keep [10] 141:16 152:18 153:

11 213:3 273:9 322:1,7,13

345:12 353:21

keeping [2] 28:22 219:15

Kefauver-Harris [1] 29:2

Kelley [5] 4:11 243:17,18 249:

12 298:11

Kelsey [1] 28:21

kept [3] 284:10,12 319:4

ketamine [138] 11:14 19:10

30:4 38:14 42:17 44:3,15 47:

2,14,19 50:7 53:12,18,20 54:12 58:6 59:13,15,18,22 60:4,

9 61:1,2,12,13,20,22 62:7,12,

12,22 63:4,15,17,19,22 64:11,

17,20 66:3 69:20 73:8 83:13

86:7,9,12,14,16 87:11,15,18

90:1,6 93:7 94:21,22 95:3,16,

21 96:17 99:9,11,14,20 117:5,

10 144:15 147:13 149:21

151:3 152:17 153:9,22 154:6,

20 155:10 156:3,10 157:9

159:6,8 160:10,16 161:16,19,

22 165:14 166:13,18 167:20

168:14 170:2,5,14,21 171:15,

21 172:18 173:13,14 174:20,

22 175:19 176:4 177:14 178:

6,16 181:17 187:3 188:8,14

189:8 191:4 207:10 213:1

214:22 216:18 271:11,12

272:7 288:10 298:14 303:20

304:6 318:11 319:2 320:1

322:2,4,15 337:19,21 338:8

340:1,4 341:7 349:9

ketamine-exposed [1] 172:

18ketamine-induced [4] 12:9

65:20 177:17,22

ketamine-treated [5] 95:12,

18 99:17 169:3 173:17

key [6] 28:2 116:1 308:12 314:

13 338:6 342:21

kid [2] 143:3 306:16

kids [31] 110:2 133:6 141:22,

22 142:5 143:11,13,16 144:1,

6,11,14 145:10 224:11 252:8,

13 301:16 303:8,11,13,20

304:5 305:19,21 310:15 327:

15,17 332:6 346:8 354:4 355:

3

killed [4] 28:6 171:10 220:17224:11

killer [1] 220:18

killing [1] 222:20

kills [1] 90:19

kilo [1] 134:11

kilogram [1] 167:12

kind [41] 80:17 106:10,18 107:

5 115:12 120:1,7 127:9 129:

8 136:20 149:17 157:13 158:

13,13,17 172:7,10,15,21 178:

18 205:14 206:2 207:14 250:

10 251:5 252:5 254:13 260:

13 264:17 265:17 274:18

276:21 278:3,20 284:13 302:5 318:3 326:9 337:22 339:16

359:3

kinds [18] 148:12 150:20 157:

19,20 165:12 169:11 171:4

175:14 181:2,6 205:10 289:

13 290:2 291:5 356:21 359:

10 361:2 362:3

Kirk [1] 219:20

Kirsch [12] 2:20 8:15,16 73:

11,12 281:19 311:18,19 312:

21 313:1 323:16,17

knocking [1] 141:12

knowing [2] 128:11 302:22

knowledge [6] 13:11 15:3,19

221:10 304:18 364:8known [13] 18:15 73:14 74:22

83:13,14 118:7 140:21 141:2

207:6 218:19 240:21 278:15

327:20

KO8 [1] 256:12

Llab [11] 114:18 117:8 118:5

124:16 213:15 256:15 267:

17 281:22 287:22 295:17

314:3

label [4] 24:1 27:12 31:8 223:3

labeled [3] 39:14 80:12 138:2

labeling [2] 24:4 138:6

labels [2] 23:12,18

labor [1] 21:14

laboratory [10] 45:2 149:13

201:22 202:15 229:9 230:16

245:15 260:20 262:8 306:6

lack [9] 73:12 82:4 189:16

221:10 263:20 283:19,20

309:16 311:12

lacking[1]

263:17landmark [2] 11:6 184:18

laparotomy [1] 196:15

large [11] 15:5 44:12 50:6 72:

1 93:9 104:2 134:10 187:19

247:10 320:5 353:5

largely [3] 110:5 262:20 265:

20

larger [3] 91:12 99:16 139:12

largest [1] 265:6

laryngeal [1] 252:17laryngospasm [2] 109:18

252:11

laryngospastic [1] 252:7

laser [1] 121:6

last [39] 17:4 22:22 33:10 53:9 72:18 73:11 85:7 97:21

106:2 108:4,14 110:16 111:

20 112:11 148:1 151:17,17

153:2 182:7,20 201:5 206:4

214:8,9 225:13,22 246:12

259:2 260:17 281:20 286:13

290:22 314:4 324:12 340:4,7

351:18 364:2,3

lasting [2] 262:11 266:4

Lastly [2] 26:17 38:2

lasts [1] 159:20

late [5] 103:7 220:19 245:6

248:21 275:19

lately[1]

320:11later [37] 5:14,16 22:12 25:2

30:4,17 31:22 36:7 39:3,6 48:

4,4 49:9 78:2,20,20 101:15

109:13 115:7 117:11 119:7

120:18 133:7 135:1 142:10

154:22 159:19 178:12 193:

15 196:14 213:19 301:2 305:

15 323:7 332:10 336:11 338:

3

laughing [2] 83:15 117:9

law [1] 28:10

laws [1] 30:11

lawyers [1] 37:5

layer [5] 87:8,8 95:12 96:10

124:13layers [2] 81:6 96:6

LCDR [4] 2:3 3:5 6:17 9:4

LDH [2] 158:5 161:1

lead [5] 106:6,15,16 308:18

339:15

leaders [1] 15:12

leading [5] 17:20 43:14 53:1

129:11 332:5

leads [2] 193:14 299:17

leak [2] 79:19 130:17

leakage [2] 130:9 131:2

leaks [1] 129:9

leaky [1] 129:9

learn [4] 165:16 211:12 262:

15 357:8

learned [6] 63:1 128:1 212:2

298:18 307:12 349:18

learners [2] 128:15 262:16

learning [21] 55:14 62:10,18

105:22 126:5,19 128:13 145:

8 256:21 257:1,6 258:9,14,15,

19 259:12 263:14 265:4 290:

16 296:16,18learns [1] 262:14

least [33] 39:9,18 56:8 75:5

77:5 104:20 105:2 128:22

133:12 146:15 159:12,20

160:20 206:9 208:16 214:13

229:14 231:13 233:14 241:

17 261:10 262:12 281:13

284:6 300:9 323:2,4 338:22

339:14 340:14 350:12 354:4

363:12

leave [2] 66:12 278:1

leaves [3] 338:1,2 340:1

led [1] 44:18

left [6] 82:2 120:15 123:18

124:7 270:6 348:6legal [1] 86:4lend [1] 363:7

length [1] 164:1

lengthy [1] 45:6

lesions [1] 196:2

less [15] 21:20 35:13 38:17

108:18 123:10 131:9 192:13

250:15 251:5 264:5 286:13

320:2 339:18 340:15 350:19

lesser [1] 335:6

lessons [1] 307:11

letting [2] 140:2,3

leukemia [1] 72:3

level[39]

24:10 60:22 64:8 70:2 78:4 86:3,5 94:5 129:9,15,

16 151:21 165:5 174:10 190:

9,11 204:22 211:18 215:6

216:2,12,15 221:22 227:3

229:4 254:16 263:12 278:18

293:10,16 300:4 327:13 337:

8,9 338:10 339:14 340:17

344:21 349:13

levels [43] 58:2,15 59:17 60:2,

5,11,19 61:2 73:7 78:4 85:21

91:20 92:1,6 94:4 99:13,20

105:18 129:22 149:16 151:3,

10,19 152:1,16 153:1,3,9,22

155:12 167:20 173:8 178:3

206:19 207:19 214:21 215:7233:18 236:4,11 354:2 360:

13,14

Levy [1] 141:6

Lewis [2] 4:10 239:19

licked [1] 283:21

LIFE [24] 1:4 2:4,12 5:4 9:9

17:5 21:22 37:3 48:21 110:

19 111:22 112:12,13,17 113:

3,9 196:14 224:4 240:3 254:

8 316:16,19 324:4,8

life-long [2] 331:18 332:5

life-threatening [3] 20:20 26:

Japan - life-threatening



14 36:11

lifesaving [1] 195:16

ligand [3] 270:16,18,19

ligation [1] 185:1

light [11] 81:11 95:4 146:13

165:4 166:13 172:19 186:2

205:10 219:11,12,13

lights [2] 170:22 219:10

likely [10] 21:19 30:20 37:12

38:5 93:14 107:3 206:5 221:

4 279:7 324:17Likewise [1] 219:2

limbic [2] 101:16 267:8

limit [3] 222:10 223:4 287:3limitations [4] 15:18 36:22

121:1 132:18

limited [9] 20:20 27:13 33:4

34:7 38:10 65:9 146:9 222:2

326:8

limiting [1] 335:11

line [9] 19:18 34:3 134:16,17

169:16 170:4 253:6 255:16

318:1

lines [3] 136:17 323:10 341:

15

link [1] 289:9linked [2] 144:17 274:12

links [1] 274:18

list [16] 82:15 106:16 109:14,

21 309:10 319:4 322:2,7,13

326:19,21 327:2,3 328:7 329:

12 333:20

listed [8] 19:18,20 74:12 109:

10 117:2 137:18 322:10 328:

4

listen [1] 148:2

lists [1] 289:22

literature [11] 41:14 45:22 52:

7 58:1 65:14 66:15 67:6 146:

11 228:6 240:7 317:1litigation [1] 30:14

little [33] 39:2 48:4 63:14 94:

10 113:19 120:11,22 126:22

127:3 128:2 141:1 146:14

152:20 171:17 176:1 177:19

179:14 212:22 213:8 230:14

231:13 233:21 249:6 263:8

265:21 267:12 274:1 279:5

297:6 339:3 341:4 344:3 345:

14

live [2] 224:8 270:6

liver [1] 246:14

Liverpool [2] 184:12 185:2lives [2] 224:3,8

loaded [1] 180:9loading [2] 165:10 291:11

local [14] 21:16 22:8 34:19 35:3 67:2 279:22 281:1,8,10,21

321:21 327:11 329:1,8

locate [1] 145:6

locations [1] 241:9

lodging [1] 218:22

Loepke [3] 88:14 90:10 91:5

logical [1] 242:7long [29] 85:4,20 86:2 104:12

108:17 112:20 116:13 119:4

127:10 141:4 143:20 169:13

181:13 185:6 207:6 211:13,

16 212:12 231:3 259:16 260:

2,2 265:9 271:17 309:4 315:

14 326:21,22 346:19

long-acting [2] 227:6 281:21

long-bone [2] 188:13 322:17

long-lasting [9] 179:19 260:

22 261:10,16,17 263:7 264:

19 265:16,22

long-term [31] 47:17 63:5,9

67:11 97:15 119:1 144:9 145:5,7,17 146:11 179:21 199:20

202:3 223:13 244:22 245:13

248:10 251:20 255:2 256:2

274:13,19 276:10 277:1 282:

13 283:1 286:16 329:3 331:

18 348:1

longer [8] 49:4 93:5 136:9,11

139:3 144:12 162:1 300:22

longer-term [1] 359:11

longitudinal [1] 290:5look [101] 13:2 14:15 32:20

34:15 55:18 56:6 58:11 78:

14 79:4 94:8 101:14 113:4

120:6 122:22 123:18 124:1

129:4 130:9,19 136:6,16 150:6 152:4 154:1 157:5 158:8,

19 159:1,2 160:2 164:5,18,22

165:2,9,12 169:19 174:17

176:11 179:22 183:22 192:4,

7,14 196:11 199:17 200:20

202:17 205:11 207:2,8,11

209:8,20 215:21 231:7,8 232:

20 234:8,10 246:8 248:17

262:1 264:3 268:19 274:3

276:17 282:16 285:12 289:

14,22 297:9 298:10 302:18,

19 305:6 314:2 318:17 321:2

325:22 327:9 328:16 329:1

337:8,13,17,21 338:11 347:7348:9 354:9 355:11 357:7,11

358:9 359:16 360:9,15,21

362:20 363:21

looked [59] 37:17 38:19 51:

20 52:7 59:17 60:2 72:6 107:

11 121:21 123:2 130:3,15

131:21 137:9,10 138:17 141:

7 144:13 159:17,18 164:12,

14,16 168:6 172:2,14 184:20

185:12 194:12,17 196:13

197:17,21 232:11 272:2 274:

9 275:19 280:19 288:12,18

292:16 295:11 299:2,6,9,21

300:11,20 301:20 316:12

317:2 324:5 326:14 327:22329:7 353:19 354:1 359:6

363:16

looking [73] 54:11 66:1 67:21

71:21 73:6 81:15 100:11 107:

10 113:7,8 120:2 128:4 142:

16 150:6 151:13 152:8 157:4,

6 158:11,21 160:2 164:11

168:8,13 170:2 173:6 174:16

176:8 179:3 191:19 195:5

196:1 197:8,12 200:13 206:3

211:15 215:18 230:16 231:7

234:5 246:22 264:2 265:7

269:14 275:15 278:3 281:1

282:13 290:17 296:11 298:

11,13 304:22 314:22 320:8

328:20 336:10 341:7 343:7

344:2 345:16,17,19,20 346:3

348:10,13 349:18 356:14

358:2 359:14 363:6

looks [9] 77:10 80:22 87:7 94:

12,14 167:14 173:16 215:11

363:15

loop[1]

255:8Lortabs [2] 226:9,10

lose [1] 114:6

loss [1] 257:1

lost [2] 128:9 220:16

lot [48] 39:19 49:19 51:19 54:

7 55:16 57:7 111:13,14 114:

7 117:5 119:17 121:1 124:19

127:22 132:17 133:22 135:9

144:2,2 149:9 167:5,13,14

173:16 174:12 178:21 192:

22 193:12 208:17 210:2,2,17

267:9 275:16 276:6 298:18

303:11 306:9 310:16 320:11

325:18 328:15 340:18 343:

20 346:2 351:11 356:3 365:10

lots [1] 101:6

lottery [1] 305:3

loud [1] 352:15

Louis [1] 84:22

love [2] 255:4,6

loving [1] 224:1

low [8] 138:14 153:9 156:3

259:20 279:22 321:19 335:

15 336:4

low-level [1] 301:1LTP [3] 268:6,14,15

lumbosacral [1] 278:9

lump[2]

122:16 296:8lunch [4] 14:10 203:6 214:9

216:20

luxury [2] 126:2 258:11

lymphoma [1] 246:13

MM.D [34] 2:2,6,7,8,9,10,11,14,

17,18,19,20,21,22,23,25,27,

29,30,33 3:3,8,11,16,19,26 4:

5,7,9,10,11,13,16,18

MAC [3] 88:15 295:4,20

machines [1] 251:11

made [14] 9:6 33:22 136:20

157:22 186:14 221:7 270:5

273:21 283:14 300:19 317:14 336:16 350:3 355:21

magnesium [15] 329:11,14

350:4,6,11,14,15,20 351:1,8

352:15 353:1,2,3 363:6

magnetoencephalography [1] 360:19

magnification [4] 77:12 81:

20 94:11 139:12

magnified [1] 78:16

magnitude [2] 77:18 339:5

main [8] 115:22 126:3 144:14

177:8 229:9 249:21 279:3

302:7

mainly [5] 111:10,21 115:2

141:7 142:18

mainstay [1] 322:17

maintain [12] 95:5 146:5 164:

1 165:6 166:13 169:12 170:

14 214:22 216:2,11,15 292:8

maintained [1] 151:21

maintaining [1] 94:4

maintenance [4] 143:8 240:

17 250:3 326:20

major[11]

60:5,21 73:7 92:14148:9 170:20 265:9 314:5

316:6 320:7 363:17

majority [6] 11:15 110:20

116:14 141:9 307:16 351:20

male [1] 73:15

malformation [2] 21:11 195:

1

malformations [2] 105:7

197:1

malformed [1] 21:8

mammalian [3] 113:5 315:1,

2

man [2] 192:1 228:19

manage [1] 187:12

manageable [1] 326:22managed [1] 127:20

management [5] 183:22 197:

4 271:20 309:1 331:2

managing [1] 253:22

mandated [1] 32:9

mandatory [1] 223:10

manifest [1] 160:19

manifestations [1] 275:21

manifesting [1] 50:14

manipulate [4] 116:17,18

117:20 131:18

manipulated [1] 242:17

manipulation [1] 190:12

manipulations[1]

196:8manner [4] 97:7 223:17 244:

19 361:21

manufacturers [4] 29:5 30:

20 31:15,18

manufactures [1] 244:1

manuscript [1] 169:17many [59] 12:17 19:5 21:21

22:18 28:7 39:14 40:2 45:20

55:20 56:2,4 75:6,7 78:11 79:

13 80:11 81:19 82:5,19 83:

10,18 84:1 95:18,18 96:18

115:21 128:6 131:2 135:17

138:6,6 139:10 144:5,5,5

145:3 148:9 167:15 178:21

181:3 194:2 195:21 196:12198:13 224:3 226:8 236:19

237:2 242:21 246:9 276:17

279:7 296:19 303:2 307:6

310:1 331:22 350:8 351:15

March [3] 1:6 256:11 294:17

margin [3] 60:12 73:9 97:14

margins [1] 72:22

Marin [1] 249:18

Mark [1] 219:19

marked [3] 16:21 43:19 275:7

markedly [3] 18:19 105:17

155:15

life-threatening - markedly



markers [3] 180:12 290:5

361:22

market [8] 28:17 29:1 32:10

222:17 223:2 226:20,22 227:

4

marketed [4] 27:18 28:4,17

29:13

marketing [11] 26:10,21 27:

22 28:2,9,13 29:7,12 31:15

32:2 33:4

marking[1]

80:5Mary [2] 200:15 345:20

Maryland [1] 1:11

mask [3] 141:15 143:4 252:17

Mason [1] 8:3

mass [3] 77:6 82:10 245:15

Massachusetts [1] 4:9

massive [8] 111:10 112:14

115:15 150:18 194:9,10 269:

18 296:18

master [1] 127:21

match [2] 315:3 351:7

matched [1] 148:20

material [1] 208:19materials [1] 243:11

Maternal [6] 20:19 62:16,2291:19 258:6 350:13

maternal-positive [1] 257:

19

mathematically [1] 138:11

matrix [1] 78:18

matter [11] 9:8,10 123:10 272:

20 273:6,22 274:14,17 275:7

287:6 305:13

matters [4] 125:9 212:17 263:

22 266:3

Mattison [8] 2:21 8:14,14

199:16 203:10,11 311:20

313:2

mature[2]

111:15 240:21maximal [2] 82:7 130:17maximally [1] 203:22

Maxwell [1] 199:15Mayes [3] 294:18 296:4 320:9

Mayo [1] 246:2

Maze [9] 126:4,4,6 128:12

198:8 232:7 258:10,12 357:

15

McCann [1] 200:15

mcg/ml [9] 60:7 73:2,10 151:4 170:9,12,16 205:22 206:7

McGowan [3] 306:1 345:8,10

McLeskey [5] 2:14 8:20,20 9:

18 10:2

McLeskey's [1] 9:21MDA [1] 294:15

mean [11] 118:1 140:19 176:5

198:10 204:3 212:6 215:19

257:11 287:10 352:15 362:8

meaningful [3] 111:16,17113:14

means [9] 36:19 51:21 80:4

108:22 138:10 219:11,12

242:7 258:18

meant [2] 22:20 109:13

meantime [1] 202:21

measure [5] 121:7,13 274:9

360:2 363:19

measured [6] 99:20 100:13

137:6,8 247:20 285:9

measurement [1] 354:15

measurements [5] 90:5 104:

6,16 167:16 340:3

measures [4] 195:6 197:8

274:7 328:12

measuring [5] 104:10 190:1

200:7 342:20 346:15

mechanical[2]

273:13,18mechanically [1] 134:15

mechanism [32] 18:16 79:10

106:7 107:1,2,3 116:12 181:

4 209:1,22 212:3 214:16 215:

2 240:4,17 241:4,13 242:11,

21 243:4,8 282:13 288:3 289:

5 294:16 313:7 337:15,17,20

338:15,21 339:14

mechanism-related [1] 361:

2

mechanisms [16] 70:9 72:14

150:10 229:17 245:17 266:9

281:7 282:20 283:3 288:12

293:21 294:3 325:14,22 336:

19 338:22mechanistic [2] 46:21 336:

20

mechanistically [1] 296:14

meddling [1] 116:8

mediated [1] 300:11

mediating [1] 72:14

Medical [18] 4:9,12,14,18 6:17:10,15 8:12 22:3 28:22 227:

17 228:22 243:2,22 249:16,

21 302:19 343:15

medication [2] 31:2 221:1

medications [9] 21:3 32:7

57:7 208:14 241:18 326:19

327:3,15 335:10Medicine [6] 6:4 110:1 116:

16 185:17 292:22 330:7

meet [2] 75:2,6

MEETING [21] 1:5,9 2:1 5:4 6:

19 9:7 13:5 14:12 74:6,9,21

218:11 219:1 222:6,9 225:7

230:3 240:1 281:20 365:20,

21

meetings [1] 199:5

MEG [1] 360:18

Melbourne [1] 200:15

Mellon [19] 2:32 3:14 5:18,18

14:4 19:1 41:4,9 69:1,6,16

70:10 71:4 72:9 73:4,17 74:1

205:22 341:4member [4] 7:1 202:9 311:9

316:14

MEMBERS [15] 2:5,13,16 11:

2 16:10 37:4 182:18 198:15

200:6 203:9 220:1 243:19,19

311:5 316:3

membrane [7] 78:17 79:3,17

98:11 115:6,9 129:7

membranes [1] 18:11

memory [17] 55:14 62:18 119:

3 145:7 256:20 257:1,6 258:

9,22 259:2,9 267:7,13 276:13

290:15 296:17,19

mental [2] 105:12,15mention [5] 61:7 71:6 83:7

84:6 128:19

mentioned [19] 59:1 65:12

66:7 69:3 87:3 166:9 216:2

235:20 239:2 253:16 266:20

270:9 279:15 293:10 298:8

303:3 306:8 320:16 329:19

meperidine [1] 28:16

Merle[1]

291:1message [2] 233:10 297:8

messages [1] 226:2

messy [1] 297:6

metabolic [3] 35:21 56:12

185:5

metabolism [5] 191:8 215:5

239:7 294:2,8

metabolite [2] 56:14,15

metabolites [1] 170:21

metabolized [1] 191:8

metabonomics [1] 289:13

metastases [1] 246:14

methadone [4] 322:9,12 323:

1 329:1

method [5] 43:10 80:9 81:1,11 348:18

methodologies [1] 336:11

methodology [3] 336:9 348:

14 349:7

methods [2] 70:2 79:11

methohexital [1] 28:16metric [1] 100:3

metrics [2] 232:10 331:3

Meyer [2] 2:29 5:12

mg [1] 136:3

mg/dl [2] 86:2,5mg/kg [32] 42:18 44:3 59:14,

14,15,22 60:9,16 61:12 63:18

64:1,2,21 69:20,20 86:17,2087:1 88:4,7 135:22 149:21

150:14 151:14 164:20 166:

18,20 191:4,5 322:18 340:5

342:12

mg/ml [1] 170:3Miami [2] 8:8,9mice [9] 67:7 79:10 91:6,18

101:4,10 133:19 153:20 362:

10

Mickley [1] 62:15

microarray [3] 298:11,13

314:2

microcephaly [1] 195:2

micromolar [5] 154:8 156:4

157:8 159:7 160:9micromoles [1] 159:9

microPET [3] 180:16 270:10

289:1

microphone [2] 219:14 345:

10

microscopic [1] 81:13

microscopically [1] 300:14

microscopy [2] 78:9 90:21

mid-gestation [4] 76:7 103:5

163:4,6

mid-synaptogenesis [1]

103:5

mid-term [1] 179:12

midazolam [28] 19:10 30:17

54:15,22 63:15,18,19 64:10,

11 87:18 118:15,16 124:10

135:22 137:18 138:19 208:

10 271:13 272:6,16,21 273:1

284:8 303:21 304:12 332:1

347:6,21

midazolam/fentanyl [1] 212:22

midway[2]

113:2 140:10might [33] 14:18 15:1,3 70:6

103:11 106:15,22 149:12

198:4 243:7 255:10 261:21

279:20 289:5,8 294:5,7 310:

7 323:20 328:12 329:11 335:

16,18,20 346:20 349:21 351:

4 356:7 361:2,22 362:7 363:

16 364:18

migrate [2] 111:14 113:13

mild [6] 20:4 105:21 106:1

150:16 242:19 291:19

milestones [3] 74:22 75:2,7

milieu [1] 111:11

military [2] 107:9 301:3

millennia [1] 76:21milliliter [1] 159:10

million [5] 235:7,9,18 264:6

287:15

mimic [3] 55:5 57:3 136:5

mimicked [1] 57:11

mimicking [1] 133:9

mind [11] 97:10,22 106:5 141:

16 152:18 153:11 204:4 265:

17 273:9 282:19 357:20

minds [1] 287:15

minimal [2] 85:8 88:16minimize [3] 222:18 242:17

286:3

minimized[1]

20:10minimizing [2] 201:21 242:

13

mining [1] 225:11

minor [1] 277:2

minute [1] 340:8

minutes [14] 10:20 41:12 42:

19 44:4 59:13 68:16 86:3 91:

10 99:7 144:12 151:17 203:6

219:17 260:5

mispronouncing [1] 42:4

miss [1] 115:12

missing [1] 37:19

mistake [1] 221:7

MIT [1] 306:10

mitochondria [4] 78:14 129:7,8,10

mitochondria-dependent[1] 300:7

mitochondrial [9] 79:16,1798:11 129:1,5 158:11,22 159:

4 177:5

mitochondrion [1] 78:15

mixture [1] 288:16

mixtures [2] 181:19 288:13

MK-801 [5] 42:10 43:8 54:13

210:18,19

MK-801's [1] 50:21

markers - MK-801's



mock [1] 55:10

mode [1] 280:12

Model [45] 3:17 12:10 42:8,1546:16,17 48:17 53:6,21 54:6

55:1 57:12 59:10 62:15 64:

16 65:1,21 67:9 92:12 107:

11,21 108:1 150:2 161:8,9

177:2 187:10,21 193:10 202:

12 205:2 233:3,15 246:13

269:11 274:16 276:2 277:16

278:7 288:2 294:20 298:12,19 328:12 340:21

models [23] 12:5 52:8 55:18

65:14,22 72:6 189:18 193:9

276:17 277:6,21 288:4,5,9,19

292:14 294:5 310:12 327:6

342:11 346:12 356:13 357:8

moderation [1] 308:12

Modernization [1] 31:12

modes [1] 180:3

modest [1] 233:18

modification [1] 265:19

modulate [1] 246:21

modulation [1] 246:17

molecule [2] 107:14,16

molecules [1] 263:3mom [3] 283:18 284:14 285:7

mom's [1] 283:20

moment [6] 24:14 58:6 83:8

89:17 301:9 330:9

moms [4] 284:9,18,21 285:1

money [4] 201:10 264:2,14

325:19

monitor [5] 108:18 168:11

252:19 253:21 255:22

monitored [3] 119:5 190:3

223:9

monitoring [10] 108:21 167:8,

13 186:9 189:17,19 244:1

250:4 252:21 253:14monitors [1] 254:16

Monk's [2] 247:17 248:6

monkey [30] 48:19 49:8 65:

21,22 67:10 93:17,19 94:1

99:9 102:7,15 104:19 156:22

162:21 163:3,16 164:14 166:

8,8 174:3,5,11 177:18 178:9

179:16 206:21 207:5,20 318:

14,16

monkeys [12] 12:8,15 95:2

99:17 156:15 163:12 207:13

214:3,11 290:19 291:4 318:

11

month [6] 112:12 189:9 271:

22 314:21 355:5,5monthly [1] 102:14

months [18] 32:11 49:10 62:

10 117:11 119:4 125:17 142:

18 144:19 163:5 189:7 212:4

232:15 246:12 262:6 296:19

305:11 317:6,7

morbidities [2] 185:6 201:21

morbidity [4] 195:13 242:14

245:9 247:4

morning [18] 5:9,14,17 6:13

7:13,18 8:15 11:1 16:9 40:15

41:9 48:5 114:15 133:15 181:

14 244:11 258:13 287:13

morning's [1] 13:15

morphine [14] 143:2 213:1

227:21 272:6,16 273:3,4,5

323:1,4,6,9 347:6,22

morphological [5] 35:16145:17 268:2,5 270:2

morphologically [3] 209:9,

16 300:13

morphology [1] 124:20

Morris[5]

126:3,6 232:7 258:10,12

mortality [5] 195:13 242:15

245:9 247:5,21

Morton [1] 200:16

most [42] 23:20 27:4 28:11 30:

16 32:18 36:10 40:8 56:5,10,

11 69:14 75:1 93:13 109:13

115:13 130:16 131:22 140:9

141:21 143:13 144:20 145:

21 150:4 190:14,19 209:15

223:19 231:11 242:7 248:1

276:9 278:10 286:19 294:16

302:18 305:1,6 325:21 334:

15 339:7 344:10 357:22

mostly [2] 271:8 331:17mother [12] 21:1,15 105:16

134:9 135:8,9 192:20,21 257:

12 279:6 283:22 351:3

mothers [4] 19:22 269:14

284:1 356:7

motivate [1] 291:6

motivated [3] 250:15 277:12

356:7

motivation [5] 211:9,18 212:

13 251:5 290:17

motivator [1] 126:9

motor [4] 62:10 276:14 285:

16 349:9

mounted[1]

186:4mouse [22] 61:11,21 63:17

64:16 77:11 80:10,20 81:17

86:1,13,17,18,19,21 88:3,15

92:12,15,16,18 93:5 246:13

move [9] 116:7 125:5,8 154:6

157:8 180:10 204:15 207:5

325:7

moved [5] 136:1 232:2,13

255:19 268:17

moving [4] 100:6 270:17 309:

3 333:4

MPH [3] 2:3,18 3:5

MRI [1] 196:1MRIs [1] 275:6

MTT [1] 158:22mu-receptor [1] 19:5

much [94] 36:10 41:3 52:15

54:6 57:20 68:14 73:22 81:6,

7 85:15 101:5 105:8 107:19

109:6 119:14,18 123:7 124:

13 125:10,11 128:5,10,14

130:10 131:9 133:1 134:11

137:3 138:20 140:13,20,21

146:2 147:4 148:4 152:1 153:

5 159:13,19 174:7 179:5 182:

16 184:4 191:21 198:1 203:5

208:12,19 213:12 226:5 230:

4 232:6 233:5,7 234:16 243:

14 244:11 249:4,5,5,6 251:19

253:7,13 255:22 256:6 260:

15,16 266:12 272:21 284:3

285:11 290:6 294:6 302:2

305:15 307:8,10 316:19 318:

14 329:8 332:20 336:15 339:

14 343:18 346:7 352:19,21,

22 354:18 355:13 356:5 358:

20 362:11

Muir[2]

4:13 249:16multi-center [1] 200:12

multi-national [1] 200:12multiple [13] 50:6 55:6,7 66:

19 67:6 150:13,19 246:3 291:

9 318:18 328:20 330:17 346:

22

murmurs [1] 109:20

muscle [4] 184:14 252:16

253:10,21

musculoskeletal [1] 38:21must [7] 24:20 25:1 31:7 48:9

85:21 237:14 239:10

mutant [1] 79:10myocardial [1] 247:8

myself [1] 205:20

NN-methyl [1] 18:3naive [1] 237:10

name [3] 5:18 220:6 224:5

narcotic [2] 135:15 186:3

narcotics [1] 22:9

narrow [2] 39:1 261:8

nation [1] 135:18

National [16] 5:15 12:2 29:17,18 30:2,5 44:21 47:2,5,12 48:

2 65:16 147:16 225:1,17 322:

3

natural [6] 43:21 77:15 117:22 273:11 353:10 358:6

naturally [2] 81:2 363:7

nature [7] 37:15 39:16 113:15

163:10 177:19,21 274:5

nausea [1] 251:22

NCTR [10] 12:6 47:1 147:16

149:20 157:3 167:6 182:6,11

290:13 291:1

Neal [1] 248:7near [3] 216:12 251:9 326:9

nearly [3] 179:17 247:5 305:

15

necessarily [6] 37:6 52:19

136:19 230:5,8 351:5

necessary [7] 21:22 58:1560:5 175:5 204:20 216:4,10

necessity [1] 20:14

necrosis [9] 18:9 50:10,15

158:7 161:2 174:3,10,12 177:

11

necrotic [2] 18:13 177:18

necrotizing [1] 344:12

need [53] 10:7 28:8 40:7 46:

15 73:20 111:12,13 117:17

120:8 146:17 159:14 190:5,9,

10 195:11 202:4 208:3 223:

17 231:8 239:11 244:14 247:

15 249:3 250:21 253:4,13

266:4,8 270:22 277:12,15

287:6 289:16 307:13 308:11,

11,19 315:6,15 316:4 317:15

318:17 321:2 325:1,13,14

327:22 329:1 330:15 342:5

344:5 348:6 359:2

needed [12] 25:16 26:13 36:

12 121:10 144:2 163:12,20

213:1 313:7 327:13 343:21

345:6

needing[1]

318:7needless [1] 132:14

needs [12] 70:13 221:21 273:

14 300:19 314:12 324:5 326:

14 331:6 349:14 358:4,12

363:4

Neil [1] 200:16neither [4] 123:8 232:16 233:

8 313:9

neocortex [1] 87:8

neonatal [21] 24:7 53:6 54:555:9 59:9 61:11 193:14 196:

6 198:17 199:15 244:12 273:

7 281:22 282:16 305:11 307:

14 308:9 317:5 324:4 331:10

357:15neonate [10] 21:5 183:22 185:

13 189:12 192:16 194:8 200:

14 271:22 344:12 347:16

neonate's [1] 194:15

Neonates [22] 112:13 184:3,

6,22 185:14 195:10,12,17,21

196:12,14 200:20 248:16

271:14 272:5 273:10 287:6

323:6 343:17 344:4 346:4

349:18

nerve [1] 279:21

nervous [12] 38:21 110:10,11

147:14 148:10 149:5 162:22

167:4 172:16 173:8 240:8,9Neuberger [1] 345:22

neuraxial [1] 34:20neuro-opioid [1] 321:11

neuro-opioid-agonist [1]

135:15

neuroanatomical [1] 62:1neuroapoptogenic [1] 97:

12

Neuroapoptosis [46] 3:13

39:21 41:6,8 54:22 60:1,10,

17 61:18 62:17 64:2,6,11,12

69:3 75:14,17 77:3 79:8 85:

13,17,22 86:8,13,15 87:2 88:

7 89:5,9,14 90:2,7,12 91:13

92:11 94:17 97:4,20 98:21106:17,18 107:3 118:21 277:

16 282:1 362:6

neuroapoptotic [3] 64:21,22

91:16

neurobehavioral [8] 65:6,877:6 103:10 274:20 275:14

346:2 358:17

neurocognitive [5] 104:8,10

105:6,11 197:22

neurodegeneration [25] 11:

7 12:15 47:14 48:14 49:17,

19 50:3,13,18 53:19,21 54:2

mock - neurodegeneration



55:12 61:21 62:2,8 63:17 65:

20 78:10 122:7 188:17 245:

16 265:3 278:16 324:19

neurodegenerative [4] 16:

19 189:1 230:11,19

neurodevelopment [1] 343:18

neurodevelopmental [11]

75:9 106:19 186:17 192:6

193:15 196:17 197:9,18 201:

2 204:2 346:4neurogenesis [7] 269:15,16

270:3,4 324:13,15,20

neurohistological [2] 104:19 179:18

neuroimaging [3] 349:4 361:

11 363:3

neuroischemia [1] 260:8

neurologic [1] 301:6

neurological [5] 13:2 16:13334:18 343:3 344:8

neuron [11] 92:22 93:14,15

94:11 98:4 100:20,22 103:4,

12 117:17 118:2

neuron-induced [1] 259:21

neuronal [25] 19:7,15 78:680:16 81:6 82:10 87:10 103:

2 104:18,20 111:4 114:1,9

116:2 140:11 146:3,7 177:17

185:15,19 256:17 260:13

294:3 302:3 321:16

neurons [55] 17:9,21 43:13,

14,17 50:15 51:10,10,13 64:

22 73:14 74:19 75:1,6,7 77:

14 80:11 82:5,11 87:12 90:

19 92:16,20 95:13,21 96:5,8,

11 98:19 102:19 103:6,8 104:

9 111:6,12,17 113:11 114:7

115:1,17 116:6,11 123:21

138:1 139:15 140:11,12,15242:5 257:19 269:2,7,19 277:

18 282:5

neuropathogenesis [3] 235:

2,14,17

neuroprotectant [2] 194:3,6neuroprotection [3] 260:7

291:16 335:8

neuroprotective [10] 194:2,

12 259:15,18,22 260:1,6,11

294:19 335:21

neuropsych [1] 264:18

Neuropsychological [1]

348:20

Neuroscience [2] 306:12

314:4neuroscientists [1] 187:18

Neurosurgical [1] 7:17neurotoxic [7] 48:11 78:19

259:17,18 260:4 297:13 335:

21

neurotoxic-protective [1]

259:15

neurotoxicities [2] 274:3

327:20

Neurotoxicity [23] 3:15,18,

22 11:12 12:9 14:2 46:2 63:

10 74:4,7 107:22 108:2 147:

19 177:15 183:12 194:7 214:

13 260:3,12,14 274:8 291:21

335:12

neurotoxicologists [1] 44:

20

Neurotoxicology [2] 147:15

314:21

neurotoxins [2] 321:4 325:4

neurotransmitters [4] 115:

22 116:4 117:21 297:3

neurotrophic[1]

299:10never [7] 23:3 127:22 134:18

212:18 215:12 303:22 345:

18

Nevertheless [2] 25:13 104:

18

nevi [1] 144:2New [18] 7:9 13:10 28:12,17

29:14 31:19 32:16,21 45:14

56:6 185:17 227:18 244:4

249:3,9 290:15 300:12 352:1

newborn [2] 242:9 257:17

next [24] 9:1 16:3 28:15 41:4,

12 52:5 74:2 107:20 147:6,

12 182:22 224:18 229:7 231:

12 234:17 236:21 239:19243:16 249:13 256:8 293:16

301:21 312:14 333:17

NICDH [1] 198:17

nice [8] 70:22 72:12 74:13

172:19 175:8 176:8 185:16

214:20

nicely [3] 148:3,4 162:12

NICHD [1] 182:11

NICHED [1] 8:14

nickel [1] 291:2nicotinic [2] 210:7,13

NICU [1] 272:13

nightmare [2] 254:4,9

NIGMS[1]

256:12NIH [4] 44:14 256:12 325:17,

19

NIH-funded [1] 346:3

Ninety-eight [1] 240:20ninth [1] 355:5

nitrous [27] 19:11 54:14,21

83:15 117:8,13 118:15,15

136:1 137:17 143:7,8,9 184:

14 210:5 251:14 295:7,12,16,

18,20 296:1 297:1,10 304:11

319:1 328:21

NMDA [53] 18:3,19 19:4,12

39:10 42:11 43:8 46:1 48:11

50:22 51:18 66:20 71:9 75:

18 76:17,20 82:17 84:2 106:8,15 116:18 117:6,9,13 148:8,

15,18 154:13,16 155:2,18

161:3,14,21 162:5 174:19

175:2 176:18 178:1 181:21

186:19 209:1,18 210:5,12,19

283:4 295:3 297:4,15 318:22

321:13 322:11

NMDA-antagonist [1] 296:9NMDA-receptor [2] 11:8,14

no-effect [1] 278:18

no-go [1] 36:10

nodding [1] 365:2

nominate [1] 47:2

nomination [1] 47:11

non-anesthetized [1] 185:4

non-cancer [1] 225:21

non-caspase [1] 300:10

non-caspase-dependent[1] 339:2

Non-Clinical [3] 3:24 183:2,4non-delayable [1] 307:19

non-human [7] 12:12 93:4

163:21 176:13 181:17 203:14,16

non-invasive [5] 165:19 180:

12,17 359:22 361:5

non-patient [1] 222:10non-rodent [1] 56:8non-selective [1] 280:1

Non-SGE [1] 2:26

non-synaptic [1] 17:19

Non-Voting [3] 2:13,26 9:19

Nonclinical [4] 33:11 57:16310:12 333:11

none [3] 120:8,9 323:19

Nonetheless [3] 38:12 48:1

65:9

nonhuman [4] 46:16 47:4,1548:6

nonrandomized [1] 246:20

nonsignificant [1] 64:1

Noon [1] 217:2

nor [1] 313:9

norketamine [1] 170:19

normal [11] 18:20 51:5 81:17114:5 162:3 173:10 198:2,10

320:8 346:8 358:2

normalize [1] 264:9

normally [9] 18:16 51:11,13

75:1,8,9 133:10 149:4 161:

13

north[1]

249:19Norwood [1] 332:10

notable [1] 30:16

notably [3] 28:11 79:3 99:10

note [9] 5:12 6:19 9:17 19:17

32:18 48:18,22 65:7 247:22

noted [20] 10:9 18:7 24:8 27:

4 33:22 39:14 42:16 44:2 46:

6 49:17 53:17 61:16,19,20

64:4 65:6 71:12,14 197:1

318:5

nothing [7] 119:2 135:7 183:

18 201:14 221:15 232:22

286:20

notice [6] 23:14 74:14 121:15

219:10 250:22 285:2noticed [2] 143:10 230:17

noting [2] 20:2 23:1

notion [2] 260:21 271:15

novel [2] 142:14,15nowadays [2] 143:9 210:11

NR1 [10] 148:19 154:15 155:2,

12,16 160:11 161:4 174:19

178:1,4

NSQIP [1] 247:9

NST [1] 281:20

NTP [2] 47:21 182:10

nuclear [6] 79:3 115:4,6,9

293:2 338:10

nuclei [4] 123:3,19 132:12174:7

nucleolus [1] 78:22

nucleoplasm [2] 79:6 115:

10

nucleus [5] 78:12 81:16 82:8

96:15 115:3

nullify [1] 288:1

number [27] 43:18 55:1 74:22

77:21 78:6 82:14 87:12 90:18 91:12 93:9 99:16 106:20

124:3 138:1 140:11 154:20

163:9 171:16 180:2 223:20

224:10 247:10 261:3 264:4

290:13 317:3 354:3

numbers [6] 23:15 81:7 120:

7 221:18 264:9 272:19

numerator [2] 38:3,6

numerous [2] 195:18 289:16

nursery [3] 308:14 330:15,16

nutritional [4] 57:10 111:11283:19 284:13

nutritionally [1] 285:10

Oo'clock [2] 182:20 217:1

O.R [1] 239:16

obliged [1] 75:3

observation [5] 141:19 143:

12 214:20 215:18 306:5

observations [2] 43:19 44:

13

observe [1] 130:18

observed [7] 18:4,18 20:3,4

58:18 75:16 130:11

observers [1] 198:14

observing [2] 121:2 203:22

Obstetric [2] 7:11 350:5

obstetricians [1] 108:11

obstruction [2] 21:8 273:18

obtain [5] 47:3 57:19 70:5 72:

13 170:16

obtained [11] 46:15 49:20 58:

2 60:2,11,19 73:3,4 95:1 120:

17 257:16

obtaining [1] 120:14

obvious [7] 71:14 105:8 115:

11 230:21 307:7 334:20 342:

10

obviously [12] 48:20 57:9

105:19 116:5 205:11 216:7

251:4,19 285:2 338:6 351:19

361:8

occasional [5] 87:9 123:19171:7 172:8 173:9

occasionally [1] 303:10

occasions [1] 149:22

occupational [1] 125:2occupationally [1] 301:1

occur [17] 18:15 49:12 50:6

75:10 77:16 98:6 101:15,16

114:5 176:20,21 179:5 201:6

202:14 279:13 293:8 306:7

occurred [4] 32:20 39:16 122:

3 362:14

occurring [20] 43:17 46:21

50:20 51:1 58:13 59:19 90:8

neurodegeneration - occurring



105:2 122:15 132:4 153:15

170:20 177:11 189:13 202:2

245:18 274:10 317:21 343:9

360:3

occurs [12] 17:4 49:9 76:3 80:

1 113:2 122:7 192:1,8 199:

22 202:17 241:8 278:7

odds [1] 234:13

off-patent [1] 32:7

offer [5] 229:3 243:1 335:1,8

365:3offered [2] 59:5 229:1

offering [1] 112:8

offers [1] 288:11

Office [5] 5:13 38:12 45:1 46:

5 58:3

Officer [4] 6:1 28:22 227:17

243:22

Official [1] 6:18often [9] 16:22 33:5 84:10

135:16 222:21 234:12 268:4

352:1 354:18

oftentimes [1] 352:18

Okay [8] 100:16 219:20 310:6

311:2,4 315:22 329:17 341:2

old [16] 101:21 261:11,18 262:9 263:7,9,12,13,15 264:3 276:

19 277:1 298:12 314:16 317:

7 320:15

older [10] 27:14 30:21,22 143:

16 176:1 179:15 265:15 307:

21 324:13 327:18

oldest [1] 251:1

oligomer [2] 231:14,15

Olney [50] 2:27 3:16 11:5,10

13:9 14:9 42:5 48:14,16 51:6

54:6 63:15 71:5 74:3,5,8 99:

6,13 100:15,18 101:3 102:12

103:14 104:5 106:14 107:18

124:15 128:17 129:6 133:14149:8 187:3 202:11 203:12,

16 209:4 256:18 277:11,14

278:1,6 279:2 280:8,17 281:

2,12 298:21 304:14 361:4,9

Olney's [14] 46:8,14 49:3 59:

4 63:11 114:18 117:7 118:4

186:14 194:18,20 267:17

269:1 295:17

omitted [1] 6:21

on-board [2] 253:13 356:1

once [11] 57:18 59:13 98:8

111:7 226:12 270:4 307:8

336:20 338:15 357:14 362:

13

ondansetron [1] 251:15one [129] 6:14 10:1 14:4 24:

16 25:17 39:9 44:6 45:20 54:

20 55:4,8,17 56:7,8,13 57:1

58:7 68:17 71:20 83:7 84:6

85:16 88:12 90:4 91:3 97:21

98:8,15 99:8 103:1 109:22

121:3 143:9 146:14 148:15,

17 151:7 153:14 155:21 158:

3 162:7 163:20 168:3 170:20

173:21 176:10 177:8 180:3

181:9 182:1,2 189:21 206:15

207:15 209:22 214:8 220:10,

10 226:2 229:1,1 232:16 234:

7 235:3 237:21,21 255:1 261:

3,5 262:21 263:2,5 266:1

268:16,22 271:1 274:5 276:

15 278:12 282:10 284:11

289:15,19 292:18 296:3 299:

5 302:16 304:20 306:1,11

307:20,20 309:17,21 310:9

311:13 313:22 314:15 316:9,

14,14 321:7 323:2,4,18 324:7,

12 327:1,12 331:3,13 335:5,13,18,22 338:1,7 339:7,8 342:

5 349:21 350:6 355:12 358:

16,18 359:3,12,20 364:7

one-third [1] 88:19

one-time [2] 85:11 86:11

ones [9] 168:15 172:20 226:

20 281:6 291:10 317:7 320:

15,20 344:15

ongoing [2] 165:17 317:18

only [54] 11:13 15:17 25:15

31:8 52:16 54:8 75:2 82:4 85:

16 94:16 97:9,14 106:9 108:

9 120:13 125:18 133:16,19,

21 135:7 137:16 143:9 150:

15 154:7 158:6 176:4 177:9179:10,20 180:12,18 187:3

211:3 212:4,15 213:13 220:

13 224:10 231:7 232:20 235:

5 236:7 239:10 261:19 264:

16 266:6 279:13 284:15 304:

21 305:17,22 311:4,8 316:14

onset [1] 276:18Opana [1] 226:19

OPEN [18] 4:2 14:11 168:15

203:7,9 217:1 218:2,3,6,10,

15 219:9 243:13 266:15,18

274:22 289:8 325:20

operant [1] 291:3

operate[1]

291:3operating [11] 133:12 136:5

137:13 187:11 188:11 189:

10 249:21 253:18 301:21

330:17 334:2

operation [2] 142:18 351:14

operations [1] 100:21

operative [1] 272:10

opiate [1] 322:10

opiates [2] 252:15 331:17

opinion [4] 96:21 97:5 229:

15 324:17

opioid [9] 220:3 225:1,8 226:

14,16,17,18 228:14 323:2

opioid-addicted [1] 226:1

opioids [22] 19:6 21:16 35:636:1 67:2 222:1,7,12 225:6,

18,20 226:4 227:7 228:8,9,10,

11,13 321:1,3 322:22 328:22

opportunity [6] 220:1 224:21

234:18 243:11 275:17 288:

11

opposed [4] 209:19 227:8

270:3 342:17

optical [1] 138:1optimal [1] 268:14optimizing [1] 242:14

option [1] 36:9

options [3] 15:20 223:15 249:

9

oral [1] 218:16orbitofrontal [1] 348:22ordeal [1] 37:10Order [16] 3:2 5:2,3,5 21:1 58:

15 74:12,13 85:5 119:20 175:

6 238:17 266:2 271:2 300:3

359:3

Oregon [3] 8:17,18 228:5

organ[4]

38:19 39:2 110:8194:18

organic [2] 250:10,21

organized [1] 146:18

organohippocampus [1]

287:21

organophosphate-induced [1] 107:10

organophosphates [1] 300:

22

organs [2] 190:13 241:5

orientation [2] 74:19 75:11

original [1] 59:7other [121] 10:5 11:14 12:7 19:

20 22:3 27:2 35:20 39:10 50:

7,21 54:12 57:6 58:7 67:1 68:21 69:2 76:10,10 78:2 79:11

83:4 101:1,14,17,18 103:6

106:12 116:7 125:20 138:21

141:9 148:20 153:22 165:12

181:9,18 187:22 200:18 202:

5 215:7,10 218:22 220:22

222:1,7,12 223:15 224:6,7,11

227:9,20 229:12 235:21 242:

5,8 245:5,15 255:9 262:1

267:11,12 268:22 270:12

271:7 272:3 274:4 275:9 276:

3,17 278:12 279:14 287:17

288:1 289:9,13 290:2 292:11

297:2,5 299:3,21 308:8,12309:5,6,19,20 311:14 313:3

314:13 316:20 324:1,7,8 327:

5,12,15,19 328:15 331:7,13

335:10,13 336:13 338:16

339:16,19 341:1 343:2 344:

16 349:4 350:1 357:9 358:19

361:7,16,18 362:3,11 365:7

others [14] 11:10 64:9 115:17,

21 149:19 256:15 262:22

284:1 291:1 317:14 331:3

342:1 353:1 357:14

otherwise [5] 145:11 146:11

336:21 342:8 347:18

ought [2] 322:12 354:10

ourselves [1] 361:10out [72] 25:14 31:16 49:6,9,1777:20 79:19 81:22 85:19 100:

5 107:17 125:8 126:9 127:5,

10 129:10 132:14 145:2 150:

3,12 151:21 152:8 153:4,7

157:3 159:13 161:3 162:16

164:2 168:1,3 171:3 190:2

191:1 193:7 195:4,10 197:22

198:4,16 200:6 203:2 208:8

224:9 252:9 253:15 261:14

264:15 265:5,8 269:1 270:13

271:10 272:9,18 273:11 282:

8 289:16,17 300:1 314:4,9,20

322:5 327:21 333:20 338:16

352:14 353:11 357:11 358:

18 363:5

outcome [21] 56:21 107:16

196:11,18 197:9 199:21 205:

8 245:13 246:14 247:3 248:3,

10 279:9 343:14,19 346:4,11

348:12 349:18 352:12 358:7

outcomes [11] 36:5 106:13

199:20 245:6 248:22 275:9276:10,20 282:17 357:2 359:

4

outlasting [1] 231:3

outline [1] 41:18

outlined [1] 81:16

outside [4] 137:3 161:14,22

357:9

outweigh [1] 33:19

outweighs [1] 27:1

over [49] 11:10 18:20 22:21

28:1 32:20 37:17 38:22 41:

11 42:19 43:2,2 44:3 49:20

52:12 57:9 68:11 76:21 81:

10 83:16 93:1 108:4 121:20

128:10 132:8 135:4,20 138:14 148:1 149:22 150:15,19

167:10 182:7 184:1 186:7

188:21 225:13 228:8,13 254:

17 262:14 264:7,7 270:4 285:

5 290:22 303:13,13 360:21

overall [3] 233:20 284:1 339:7

overcome [1] 254:14

overdose [3] 206:12 222:19

228:18

overlap [1] 205:13

overly [3] 109:7 210:1 296:8

overproduces [1] 232:4

oversedation[1]

109:19oversight [1] 225:5oversimplification [1] 229:

12

overstate [1] 225:15

overstimulation [1] 193:20

overturned [1] 31:22

Overview [7] 3:9,20 14:5 16:

3,7 147:17 175:10

overwhelming [1] 364:14

own [13] 59:2 149:13 196:22

202:2 206:3 221:1 239:22

250:4 273:12 298:13 301:11

307:3 361:11

Oxford [1] 184:20

oxidative [2] 181:7 293:19oxide [21] 19:11 54:14,21 83:

15 117:8,14 118:15,15 136:1

184:14 210:5 251:14 295:7,

12,16,20 296:2 297:1 304:12

319:1 328:21

OxyContin [21] 220:22 221:3,

4 222:1,7,11,15,17,20 223:4,

7,16 224:11 225:14,16 226:3,

21 227:5,18,20 229:1

OxyContin-related [1] 224:

14

OxyCotin [1] 227:13

occurring - OxyCotin



oxygen [8] 90:6 100:12 137:7,

7,10 167:18 168:9 252:15

Pp-1 [1] 133:3

P-119 [1] 259:1

P-120 [1] 258:17

p-3 [1] 133:3

P-36 [2] 258:16,22

P-5 [1] 314:10

P-6 [1] 314:10

P-7 [5] 314:1,5,8,10,16

P-75 [1] 300:2

P-8 [1] 314:10

P-9 [1] 314:10

p.1 [1] 123:8

p.14 [1] 123:8

p.m [2] 217:3 365:21

PACU [2] 250:11 251:13

Pain [28] 6:4 21:13 35:16 137:

2 184:3 185:12,15,20 193:13

199:15 201:17 220:18 223:5,

10 225:12,15,21 227:16,16

228:1 304:7 308:22 316:5

317:8,19,21 328:5 331:2

painful [3] 68:19 193:8 303:15

pair [1] 316:15

pairs [1] 316:13

Palladone [3] 223:1 226:19,

22

panel [15] 43:6,7,12,19 123:18 124:1,1 125:15 128:18

183:7 191:2 198:15 200:5

203:9 207:8

panelists [1] 187:22

panels [1] 199:5

paper [26] 19:1 42:1,2,7 43:1

44:2,16 45:7 53:3,4,7,17 54:

4 55:16 59:5 65:5,19 70:19

90:3 114:20 144:22 145:5

147:2 191:18 306:11 323:5

papers [9] 44:6 45:8 52:10

54:20 198:22 243:3 252:2

262:19 269:6

paradigm [6] 121:11 125:21

139:21 187:21 189:8 324:16

paradigms [3] 125:22 283:14

324:1

parallel [1] 168:16parallels [1] 346:11

paralysis [1] 184:16

paralyze [1] 134:17

parameters [3] 137:2 160:15

169:15paravertebral [1] 246:21parent [2] 4:3 306:3parenteral [1] 23:5parents [7] 15:16 142:4,7

305:8 306:5,14 308:5

parietal [2] 132:6 139:7part [19] 9:6 27:15 40:8 44:1250:6 51:5 54:9 59:16 135:16

162:11 188:13 235:13 297:

15 306:13 320:1 322:2 326:

12 333:22 362:8

partial [1] 97:10partially [2] 77:5 318:15

participant [1] 10:6

PARTICIPANTS [4] 2:28 9:

13 10:7,10

participate [2] 9:18 360:4

participation [1] 239:22

particular [63] 9:10 10:1 13:

19 19:10 42:7,13,15,22 43:4,

6,16 44:1,2,8,12,16 45:5,7,16

46:19 48:22 51:18 53:16,21

54:9 55:2 58:8,20 59:5,16 60:

3,11 61:9,17 64:8,20,22 65:15 66:18 67:12 68:11 70:15,

16 84:6 93:20 108:7 110:2

113:6 119:12 129:13 151:4

152:7 154:12 165:5 166:21

250:19 292:13 293:13 299:

11 322:9 324:2,14,16

particularly [17] 17:10 46:20

58:20 112:13 201:20 283:4

285:6 288:10 292:16 308:9

310:14 317:21 322:12 324:

10 337:10 348:14 363:6

parties [2] 9:10 226:10

parts [2] 101:17 195:19

party [1] 229:1

passed [2] 28:10 29:3passing [1] 279:15

past [4] 28:1 32:20 75:5 320:

21

patent [2] 185:1 196:15patented [1] 32:7

path [2] 127:7 339:20

pathogenic [1] 263:2

pathologic [1] 339:20

pathological [1] 51:16pathologist [1] 123:17

pathologists [1] 113:18

pathology [2] 80:17 114:21

pathway [18] 79:12,16 106:19

107:13 129:5,13 131:12 276:8 298:16,22 299:4 300:7,8

338:11 339:11 348:22 349:

10,12

pathways [11] 18:2 107:7

128:18,22 294:8 300:9,11,13

348:22 349:1,2

patience [1] 306:9

patient [20] 13:4 20:9 35:4 37:

7,20 40:6 188:10,10 190:2

197:2 212:18 245:12 247:22

249:10 252:10 253:17 255:

17 265:18 286:15 351:12

patient's [2] 190:10 196:7

Patients [87] 3:10 12:22 16:5,

8,15 21:20 23:19,22 24:9,1230:22 31:10 32:19 33:9 34:1,

2,22 35:8 37:4,4 38:17 40:8

142:17 184:13,21 187:12,15

189:21 195:14 197:14 201:4,

19 202:6,17,20 203:1 208:4,

12 223:17 225:20,21 226:1

228:1 230:9 234:9 235:18

242:15 244:7,10,16 245:5,20

246:9 247:9,10,11 248:5,17,

17 250:11 251:8 252:6,16,18

253:15 254:21 255:15 262:2

264:7,9 266:11 271:20 272:

18 303:11 309:1 310:18 330:

16 331:5 340:16 343:4 344:2,

10,11 345:6 353:19 357:22

360:4

Patrick [1] 228:19

pattern [8] 78:1,5 80:17 81:4

95:11 102:17 124:13 274:6

patterns [2] 62:1 96:5

paucity [1] 24:9

Paule [1] 291:1

payment[1]

218:21PCO2 [1] 137:6

PCP [1] 83:14

peak [22] 65:2 112:10,22 113:

4 118:19,22 119:10 123:4,5

131:22 145:20 150:3 162:18

191:14,19,19,22 192:5,7,17

203:19 269:8

peaked [1] 65:1

peaks [3] 193:4,5,5

Pediatric [70] 3:10 7:6,14,19

8:6 11:16 12:22 13:17,18 15:

4,15 16:5,8,15 21:20 23:13,

19 24:4,9 27:12 31:7,10,17

32:9,14,16,19,21 33:5,8,12,

14,16 34:2,4,22 35:8 38:1640:6 71:21 73:3 97:13 108:6,

7,10 135:16 183:11,14 189:

13 198:13,19 200:10,18 202:

9 244:7 248:16 249:1,22 255:

15 291:14 306:18,20 307:17

308:15 322:19 330:13 331:5

334:13 343:4 364:9

pediatrician [1] 8:11

Pediatrics [7] 8:7 15:13 73:5

110:2 213:14 326:17 328:6

peer [1] 250:14

peer-reviewed [1] 240:7

pellets [1] 291:4

pending[1]

28:9penetrates [1] 350:12

Pennsylvania [2] 4:8,17

pentobarbital [2] 143:1 319:14

pentothal [1] 28:4people [35] 30:21 37:2 40:20

111:1 113:17 126:20 147:9

182:5 212:7 216:8 221:17

224:2,3,7,15 226:8 236:20

250:17 252:4 254:14,16 255:

10 270:21 288:12 308:16,18

309:5,7,12 319:5 329:22 350:

13 359:15 361:11 363:17

peptides [1] 234:3

per [9] 141:3 159:10 166:20215:9 222:16 249:20 261:21

317:16 338:9

perceive [4] 184:3 185:15,19

319:22

percent [52] 82:9 84:11,12 88:14,17,17,19 89:3,7,12 90:9

91:9,11 92:3,3,4,7 107:15

114:8 130:1 136:2,2 140:13

142:1 143:14 164:13 166:10

169:2,8 175:18 179:10 198:3,

9 232:11 236:6,15,16 240:20

257:13,15,21 259:4,8,10 262:

5 269:2,7,20 295:19 307:16

346:10 352:4

percentage [2] 75:3 360:9

Percocet [2] 226:9,10

perfect [4] 102:13 121:11134:19 286:1

perform [1] 199:10

performance [3] 62:11 127:

17 263:22

performed [15] 14:6 21:22

22:2 33:5 36:11 84:21 93:18119:22 120:13 121:17 127:

16 141:13 199:20 200:20

285:20

perfusion [1] 190:6

perhaps [41] 51:8 55:2 60:22

61:4 62:2 64:8 67:14 107:7

150:21 158:6,7 162:15 180:

13,14,19 184:15 186:20 187:

9 189:11 191:8 193:4 194:6,

11 195:4 197:5 202:13 204:6,

18 212:17 216:12 255:8 261:

5 272:4 289:20 290:4 292:2

293:1 320:17 337:19 338:12

344:16

Perinatal [3] 65:21 191:22230:5

perinatally [1] 276:18

Perinatology [1] 7:12

period [56] 12:10 16:21 17:2,

9 18:5 22:11 31:14,14 42:20

49:1,8,11,16 66:4,4 75:22 76:

1,2,3 84:5 90:7 93:5,20,22

102:22 103:6,7 104:1 150:1,

15,20 162:17 171:12 172:22

192:5,7,17 193:14 201:5 202:

7 204:4 230:5 231:3 269:9

272:11 280:5 305:11 307:14

324:4 331:10 332:12 340:10,

17 341:9 359:7 360:22periodically [2] 83:16 232:13

periods [15] 52:3 63:8 85:5

93:21 157:20 169:13 179:8

192:11 308:10 313:6 346:19

353:2,13,14 357:18

perioperative [1] 202:7

perioperatively [2] 21:3 22:

19

peripheral [2] 223:5 279:21permanent [3] 82:11 257:1274:19

permeability [1] 79:18

permit [1] 243:13

persistent [2] 55:13 265:4

person [2] 224:1,3personal [4] 221:13,16 336:1342:2

personality [3] 142:12 143:

10,15

personalized [1] 292:22

personally [3] 265:13 336:1

348:15

persons [1] 28:7

Perspective [13] 3:24 13:13

41:19 56:1 57:16 61:4 68:4

71:8 86:4 89:18 183:11,14

342:2

oxygen - Perspective



perspectives [4] 46:21 68:

13 183:1,3

pertaining [4] 79:13,14 93:7,

18

perturbations [1] 242:10

PET [2] 270:13,19

Pete [1] 228:16

Peter [6] 4:3 219:18,21 220:6

225:4 249:1

Peterson [1] 275:3

Petition[2]

222:16 223:3pH [1] 137:6

Ph.D [13] 2:6,17,19,23,24,31,

32,33 3:11,14,19,23 4:16

phagocytic [1] 82:1

phagocytosis [1] 115:16

pharm-tox [1] 45:13

pharma [1] 8:21

Pharmaceutical [5] 10:3 45:1 46:5 58:4 99:2

Pharmaceuticals [1] 32:5

pharmacodynamic [1] 58:9

pharmacokinetic [2] 57:19

215:8

pharmacologic [1] 350:11

pharmacological [2] 71:7331:20

pharmacologically [1] 280:

4

pharmacologist [2] 7:20 8:

11

pharmacologists [1] 14:5

Pharmacology [1] 45:10

Pharmacology/Toxicology [1] 5:19

Phase [5] 33:6 165:20,21 166:

4,4

phenobarbital [1] 194:22phenomena [16] 43:14 44:1

45:5 46:19 50:18 56:9 58:1865:8 68:6 84:5 85:3 149:15

151:8 158:20 179:1 278:4

phenomenon [34] 44:9 51:5

52:9 53:2,13 55:3 66:20 67:7

69:10 75:20 76:11,15 77:16

78:8 79:14 82:17 83:1,5,7,22

85:5,10 112:19 114:4,12 115:

12,14 122:15 130:10 134:8

209:14 212:10 216:7 266:11

phenotype [23] 71:12 103:16

104:4 195:1,4,6 233:7 278:

14,16 287:11 302:16 303:5

304:19 306:8 343:6 345:15

346:15 347:7,11 348:2 359:5

363:20,21phenotypic [1] 356:14

phenytoin [1] 194:21

Philadelphia [1] 7:21

phobias [1] 316:21

phosphorylated [3] 299:16,

22 300:4

phrased [1] 311:3

phrasing [1] 332:16

physical [1] 125:2physician [1] 228:22

physicians [3] 97:2 188:12

322:16

physiological [19] 51:4 58:13 77:15 87:10,14 114:2,4,11,

22 136:17 137:3 165:6 167:8

169:15 189:16,19 207:17

269:3 270:5

physiologically [2] 122:15

164:2

physiology [1] 206:16

pick [2] 298:16 337:18

picked [2] 276:10 323:8

picture[8]

81:17 82:8 123:13,22 124:14 137:21 220:12

297:9

pictures [1] 224:13

pig [5] 67:8 136:1,19 140:5

315:5

pigs [14] 101:11 112:7,18 113:

1,8 134:4,6,21 136:3,8,18

214:3 321:16,20

Pike [1] 1:10

pill [1] 28:18pilot [2] 257:9 272:22

place [12] 43:21 45:7,21 127:

2 128:10 212:3 223:7 255:16

258:15 330:8 341:20 353:9

placebo [2] 272:16 273:2placed [1] 168:10

placement [1] 21:9

plain [1] 98:12

plan [7] 199:17 200:19,21 201:

1 206:20 293:15 320:13

plane [9] 82:7 95:4 165:4 166:

13 170:14 207:12,14,18 216:

16

planning [1] 158:9

plans [1] 274:2

plaque [1] 233:22

plasma [23] 18:11 59:17 60:2,

11 73:7 100:4 151:2,10,19

152:2,16 153:1 167:20 169:20 206:19 207:10,19 214:12,

14,21 215:6 216:19 340:2

plastic [1] 81:12

plasticity [1] 200:4

plateaued [1] 216:13

platform [13] 126:10,11,13,14,

15,16,18 127:1,7,14 128:4,6

232:12

play [3] 191:12 221:14 291:7

playing [1] 293:19

plays [1] 148:9

please [5] 10:17 224:6 254:6

310:9 315:10

pleasure [1] 148:2

plop [1] 143:3plus [4] 61:13 64:11 231:20

242:19

pneumonia [2] 247:14 347:

17

podium [1] 219:10

point [84] 49:17 51:9 66:1367:3 68:9 69:15 70:11,12,19

72:9 73:18,20 98:6 100:4,5

113:20 115:5 118:7 130:11,

19,19 140:4 142:6 148:15

149:11 150:12 155:15 163:1

165:11 166:5,19 168:3 171:3

177:7 192:10 194:1 195:10,

20 197:10 198:4,16 200:7

208:3 213:7,20 215:11 224:9

229:15 234:7 261:14 264:15

265:17,20 271:7,10 273:21

276:1,2 278:20 283:16 284:

16 293:22 300:19 302:17

304:18 308:4 312:14 314:1,

14 316:6 319:5 322:21 334:9,

9,10 336:6,15 338:1 339:1,12

340:1,12 341:14 360:10pointed [10] 150:3 162:16

191:1 193:7 195:3 208:8,15

265:5 269:1 322:5

points [12] 14:14 104:15 164:

6,8,12 190:8 191:19 257:22

310:8 317:14 319:3 338:18

poisoning [1] 192:21

poisonous [2] 28:6,14

poisons [1] 283:8

policy [2] 222:10 223:19

poll [1] 320:5Pollock [7] 2:22 8:2,2 286:7,

8 312:1 313:13

polymorphism [1] 294:10

polymorphisms [3] 293:3,11 360:15

poorly [2] 343:18 346:9

popping [1] 210:9

popular [2] 253:8 292:13

populated [1] 82:5

population [29] 13:4 20:9 24:

2 33:4,16 39:21 40:6 71:21

72:1 73:3 114:9 230:7 260:

12 261:15 265:19 331:7,9,12

332:6 349:17 350:5 351:13,

13 352:7 353:6,6 354:9 355:

18 356:6

populations [11] 24:5 27:5

33:3 38:9 248:15 277:18 343:7 347:4,13 362:22 363:16

portion [3] 14:12 284:6 333:5

portions [1] 278:11

pose [2] 97:1 346:17

posed [2] 223:18 364:11

position [5] 232:12 251:6

253:9 325:3 338:16

positive [5] 25:4 26:8,19 95:

17 279:16

positivity [4] 96:6,9,11,13

possess [1] 83:11

possibilities [1] 181:18

possibility [11] 13:2 25:11,14

142:12 181:16 290:3 292:15

323:20 361:16 363:3,5possible [18] 20:11,14 27:2

51:6 57:4 97:5 98:14 106:13

145:7 164:4 171:1 225:2 253:

6 255:21 296:11 303:3 304:

17 361:8

Possibly [3] 72:13 130:8 257:

6

post [3] 36:18,20 54:16post-anesthesia [3] 144:19

286:5 296:20

post-birth [1] 296:19

post-Day [1] 257:16

post-natal [30] 53:6 59:10 66:2,5 111:22 112:13,17 150:2

157:1 166:10 169:7,9 170:10,

13 171:18 172:7,9 175:22

176:2 178:10,12 179:16 214:

12 257:6 258:4,10,20 259:9,

13 292:14

post-natal-day [1] 314:1

post-natal-day-5 [1] 259:7

postconceptual [1] 108:19

postmarketing[1]

33:6postnatal [3] 186:18 192:2,9postnatally [1] 150:5

postoperative [4] 185:6 197:

18 247:14 330:4

postoperatively [1] 35:22

postpone [1] 307:20

postulated [5] 75:5 77:4 92:

21 162:20 163:2

posturing [1] 252:5

potency [4] 125:12 226:4 227:

6 231:5

potent [3] 42:11 226:14 231:12

Potential [36] 3:21 11:11 14:

1 26:1,11,13 31:5 41:20 46:147:13 49:21 51:21 52:2 57:

21 63:15 77:5 97:12 147:18

202:14 222:11,19 240:2 242:

8 244:12,14 246:17 261:10

275:17,18 283:8 288:11 293:

20 317:16 327:14 343:3 350:

1

potentially [6] 58:10 67:22

96:22 306:7 347:10 362:20

potentiate [4] 116:20 117:4

238:9,19

potentiates [1] 71:9

potentiation [1] 119:2

power[4]

219:13 246:8 345:5,7

powerful [1] 290:6practical [4] 83:10 242:13325:13 326:1

practice [25] 15:4 117:20 183:

9 184:11 186:15 188:7 213:

14 243:2 244:3 249:16,22

253:7 301:11 305:20 306:1,

14 307:3,17 308:1 313:11

320:1,8 334:15 335:5 364:8

practiced [1] 225:10

practices [2] 189:14 328:3

practicing [3] 310:15 316:3

320:6

practitioners [3] 201:16 202:16 309:21

pragmatic [1] 44:1

pre-birth [1] 196:2

pre-existing [1] 195:22

pre-human [1] 282:12

pre-op [2] 208:13,14

pre-term [5] 272:12 273:15

275:4 317:2,4

preach [1] 221:16

precedent [1] 300:21preceding [1] 340:10

precise [4] 189:16,18 211:8

perspectives - precise



241:9

precisely [1] 104:7

Preclinical [45] 3:12,15,1713:14 14:6,17,21 15:5 33:7

40:14 41:5,7 56:1 68:2,18 72:

5 74:4,7 107:21 108:1 244:8

245:16 246:11 248:11,20

288:9 291:14,19 298:1 304:

15 308:5 318:3 319:6,15 327:

6,13 328:9,11 331:14 334:4,

15 342:11 346:12 350:21353:8

preclude [2] 9:6 219:8

precludes [2] 309:17 311:12

precocial [1] 101:11precondition [1] 259:21

predecessors [1] 191:2

predict [2] 72:15 293:5

predicting [1] 69:13

predictive [1] 349:22

predominantly [3] 41:13 73:

5 281:9

preeclampsia [1] 352:17

preemies [2] 307:14 330:14

preemptive [1] 273:5

prefer [1] 207:14preferably [1] 146:19

preference [1] 336:1

pregnancy [27] 17:7 20:1,4

24:15 25:1,9,12,15 26:7,17

27:9,13 69:4 108:15 110:16

111:21 112:19 113:2 134:22

135:1,1 136:19 140:10 269:

18 276:21 279:8 351:19

pregnant [22] 24:20 25:5,2226:12 27:1 93:19 134:9,21

136:18,22 140:2 168:14 169:

4 257:4,12,14 259:5,8,11 269:

14 349:17 363:5

preliminary[8]

12:11 93:8,10,13 163:21 164:3 282:7 298:

13

premature [10] 35:21 109:1,2

184:22 239:15 271:21 286:

10 331:22 343:16 344:12

prematures [1] 330:14

prematurity [2] 196:21 275:

11

premise [1] 208:18

prenatal [1] 191:21preparation [2] 208:13 227:

13

preparations [2] 227:9,10

prepared [1] 243:3

Preschool [1] 345:22prescribe [2] 223:12 225:18

prescribed [2] 220:19 221:1

prescription [7] 220:2 221:9,

12 222:1,12 225:1,7

prescriptions [1] 223:8

presence [4] 12:14 244:18

283:20 334:6

present [16] 9:15 13:8,21 14:5 68:13 96:20 144:18 147:21

195:17 198:14 242:22 243:

11 261:13 350:10,18 351:2

presentation [12] 10:15 16:3,

12 22:13 40:22 71:1,18 74:2

218:13 243:15,16 271:9

PRESENTATIONS [11] 3:6

10:21 13:15 14:7,9 17:16

148:2 203:7 267:1 324:7 365:

14

presented [18] 41:15 42:9 67:

19 72:8,20,22 103:20 184:7

205:18,18,22 209:2 213:21

267:9 275:1 277:15 287:13

340:3presenter [4] 41:4 219:17,18

260:17

presenters [1] 10:17

Presenting [4] 2:26 48:4 71:

6 74:11

presents [1] 197:3

preserve [1] 21:22

President [1] 7:10

President-Elect [1] 7:16

press [1] 320:11

pressing [1] 304:7

pressure [8] 121:3,3 137:6,

11 190:3 254:1 257:11 295:

21

presumably [1] 221:2presumed [1] 263:2

pretraining [1] 127:4

pretreatment [1] 208:10pretty [29] 36:9 42:14 76:2 81:

22 119:14,18 124:12 128:10,

13 130:10 137:4 138:20 139:

16 152:1,17 153:5 191:21

198:1 213:12 253:7 254:17

265:15 285:1,11 290:20 300:

5 331:21 358:2 364:10

prevent [2] 146:7 311:7previous [8] 10:12 27:8,8 31:

3 193:18 226:11 281:10 302:

19previously [7] 8:21 79:12 82:

5 129:2 189:2 262:14 266:6

primarily [10] 24:3 49:18 50:4

51:15 93:12 177:20 294:15

320:4 341:7 353:20

primary [15] 42:9 45:20 52:6,

14,20 68:10 73:18 84:13 153:

17 156:21 191:9 251:16 327:

19 345:4 364:16

primate [27] 12:9,12 46:16 47:

4,15,18 48:6 93:14 102:5

134:1 156:18 158:4,16 160:7,

16 163:21 167:14 176:14

177:10 180:1,7 181:17 182:

10 203:15,16 282:12 301:3primates [3] 93:4,7 263:18

principle [1] 126:7

principles [1] 359:1

prior [5] 33:8 81:13 234:10

341:17,19

priorities [1] 341:21

prioritize [1] 289:21

priority [8] 326:7,11,14 329:

20,22 330:6,11 332:19

private [3] 201:10,10 249:15

privilege [1] 147:21

probable [2] 229:14,15

probably [24] 99:18 113:7

125:5 145:4 163:3 174:11

177:18 189:6 201:7 206:22

215:20 233:22 252:2 280:22

286:9 320:2,9 324:18 337:7

338:8,9 340:19 353:15 360:

17

probe [2] 121:7,12

probes [2] 128:3 171:4

problem [26] 36:16 45:16 97:

2 104:5 145:7 192:18 193:22200:11 220:2 221:11,15 222:

6 225:2,4,17 226:3,21 227:1

229:5 265:10 284:15 319:7

330:8 354:10,10 363:17

problematic [2] 64:9 67:16

problems [15] 109:19 127:22

187:20 193:15 196:22 198:5

208:8,12 235:4 276:13,22

285:16 303:22 355:10,16

procedure [9] 21:3,19 22:4

141:13 143:15 144:4 216:4

261:22 272:10

procedures [16] 15:16 20:20

22:2 34:21 35:7,13,19 36:10,

12 53:13 72:3 109:17 142:20264:4 317:4 330:18

proceed [2] 14:18 355:22

proceedings [2] 199:14 217:

2

proceeds [2] 52:16 347:18

process [27] 15:22 43:21 51:

8,12 77:17 78:11,19 80:2 81:

9 90:20 113:12,22 114:7 158:

12 186:20 187:5,14 218:8

240:11 241:3,14,21 273:12

274:12 288:2 339:9,10

processes [3] 274:10 277:3

339:6

processing[6]

236:9 237:11,13,19 238:17 276:12

produce [37] 44:5 49:22 53:

18,20 54:1,22 56:13 58:15

60:1,10,16 61:1,3 62:4 63:16

83:4,11,21 85:5,9 86:10 90:

12 95:4 98:18 100:21 150:1

156:10 178:17 194:19 204:

20 233:14 236:10 265:3,4

271:3 341:10,11

produced [24] 51:21 52:9 55:

11 56:14 61:21,22 62:7 64:1,

10,11,21 75:17 82:22 87:1

89:9,13 99:21 103:11 104:8

106:20 229:16 231:15,21

233:5producer [1] 83:6

produces [2] 195:1 331:17

producing [1] 177:9

product [5] 27:18 31:9 32:2139:15 218:18

production [6] 235:12 240:

10,18 241:20 242:10 263:3

Products [20] 5:11,21 6:2 10:

5,13 11:16 13:18 20:17 23:

17,20 24:16 27:16 28:3 29:7

30:12 31:20 32:17 33:12 70:

15 334:12

professional [1] 142:4professionals [1] 249:8

Professor [6] 6:8 7:2 8:1,16

306:10 316:10

profiles [6] 81:20 87:10 95:

17 96:13,16 319:1

profound [3] 125:7 184:8

267:18

Program [5] 47:3,5,6,12 219:

16

programmed[3]

18:8 74:20114:1

programs [1] 198:20

progress [4] 48:5 145:15 270:

20 361:14

progressed [1] 216:4

progression [1] 233:2

project [3] 248:9 256:11 348:16

proliferate [1] 111:6

proliferation [5] 111:5,11

241:11,16 242:1

prolonged [5] 11:20 272:5

283:6 308:10 330:22

prominent [1] 78:5

promising [1] 228:20promote [2] 230:11 358:7

promoters [1] 324:15

promotes [1] 241:22

promoting [1] 116:1

promptly [2] 147:10 216:22

promulgated [3] 31:6,17 32:

1

proper [1] 33:15

properly [3] 36:6 117:18 206:

13

properties [9] 76:20 83:12,

19 84:1,3,14,15 97:17 290:16

Propofol [13] 30:17 88:1,2

231:13 250:19 251:7 252:15,18 255:9 298:4 304:13,14

320:4

proponent [1] 165:8proposals [1] 243:4

propose [1] 349:8

proposed [2] 44:14 281:17

propylene [3] 83:8 84:7,11

prospective [2] 255:3 264:

17

prospectively [1] 359:18

protect [2] 130:8 154:17protection [5] 101:1 220:7

292:3 293:21 304:8

protective [5] 231:14 335:16

337:11 358:6,6protects [2] 129:8 294:21

protein [7] 155:12,14 230:16,

20 235:11 236:10 289:3

proteins [6] 131:14 155:7

230:15,18 289:5 293:9

proteomic [1] 166:2

proteomics [1] 289:13

protocol [14] 93:19 94:21 95:16 99:19 122:4,8,10 125:11

130:5 137:16 143:17 258:12

295:19 305:14

protocols [3] 97:13 118:10

precise - protocols



135:17

protracted [1] 93:1

proud [2] 146:6 210:4

prove [1] 29:6

proven [1] 243:1

provide [14] 15:1,2,8 21:11

33:12,15 40:3,7 69:12 111:

11 165:19 188:14 203:1 345:

7

provided [4] 12:4 14:15 28:

13 60:12provides [1] 77:4

providing [4] 11:12 21:13

260:7 292:2

provisions [1] 32:8

psychiatric [2] 38:21 142:6

psychological [3] 254:14316:22 317:10

psychologist [1] 8:6PTCC [1] 45:12

PUBLIC [19] 4:2 14:11 29:1

66:15 97:1 217:1 218:2,3,6,8,

10,15 219:9 222:6 223:18

265:7,9 266:15,18

public-health [1] 235:3

publication [7] 12:13 45:854:10 65:15,19 70:16 247:8

published [36] 11:5 19:1,3

41:14 42:2 45:20 46:3 52:7,

18 54:5,20 59:6 65:5,14 66:8,

9,15 67:5 86:19,20 90:19

135:4 141:6 145:6 149:18

157:2 161:9 198:22 231:19

232:3 246:12 272:15 275:4

299:9 314:3,20

pull [1] 114:20pulmonary [1] 21:9

pump [2] 252:18 253:2

puncture [1] 120:16

pup[2]

43:6 281:22pups [9] 43:5 61:11 73:15,15

187:20 188:22 191:5 256:20

298:14

purchase [1] 121:6

pure [2] 69:15 210:19

purely [1] 69:8

purpose [1] 261:2

purposes [1] 328:7

pursue [6] 46:18 70:14 101:7

271:2 292:19 293:15

pursued [1] 47:22

pursuit [1] 294:12push [2] 311:16 320:10

pushed [1] 283:21

pushing [1] 52:11put [16] 114:8 121:12 126:11134:15,16 161:8 185:16 191:

17 263:8 303:16 305:9 312:

18 318:13 355:1 357:11 358:

17

putamen [3] 87:13 94:9,13

putative [1] 321:4

puts [2] 246:7 330:18

putting [3] 173:20 199:1 213:

2

puzzling [1] 299:20

pyramid [1] 74:14

pyramidal [1] 95:13

Qquadrant [1] 128:6Quality [3] 8:18 197:6 331:4

quantify [1] 138:1

quantities [2] 241:9,12

question [76] 15:9 51:18 58:

21 66:18 69:2,17 71:1 73:11

85:20 86:11 97:7 100:2,10

106:2 117:22 124:18,20 133:

19 139:14 156:16 194:14

203:11 205:20 206:3,15 208:

1,17 214:8,9,19 221:13 230:

21 234:5 254:22 267:5,15

268:22 272:9 274:1 277:9,22

278:12 282:10,18 285:22

286:8 288:8,20 294:14 301:

20 303:7 304:4 305:19 309:9

311:3 312:18 314:11,13 315:

10 326:7 333:1,8,9,15,17 337:

2 341:2 342:22 346:18 349:

15 357:20 361:3,10 364:2,3,

11

QUESTIONS [28] 4:21 12:18

15:11 40:20,21 68:16,17 72:18 73:20 99:7 135:3 147:2

182:19,20 203:9 243:9,14

266:21 270:7,9 276:16 278:2

279:14 309:2,4,5,6 365:6

quick [2] 127:7 363:13

quickly [11] 92:17,18 148:4

151:22 167:11 170:6 333:4

338:2,2 340:2 361:3

quiet [1] 353:21

quite [40] 38:10 77:3 83:6 96:

8 108:12 109:20 111:5,13

127:15,17 131:8,9 132:10,11

138:22 139:3 141:14,16 143:

19 156:4 184:1 196:13 267:

20 268:20 284:3 285:4 294:6

296:3 299:13 308:5 316:6

323:12 338:12 342:22 343:

12 345:3 350:13 354:5 355:

10 363:19

quote [1] 183:17

Rrabbits [1] 192:3

Rabinowitz [1] 269:5

race [1] 32:4

racemic [2] 288:13,16

Radial [2] 126:4 128:12raise [6] 12:17 73:19 149:9

306:19311:

7313:

4

raised [8] 44:13 89:20 91:4

92:15 107:6 220:10 281:16

327:8

raises [1] 106:9

Raja [12] 2:9 6:3,3 72:19,20

267:5 288:7,8 312:12 315:21

327:7 337:2

ran [1] 251:12

randomization [2] 347:6

351:6

randomize [2] 347:5,20

randomized [11] 184:22 185:

2 199:10 247:10 262:2 264:

17 272:14 343:21 347:1 352:

10 362:17

randomizing [1] 200:21

range [19] 19:20 86:22 87:5

88:5 89:12 90:8 99:21 136:

18,21 137:3 151:3 159:3,9

163:6 169:2 170:11 193:3

206:10 350:12

ranging [1] 37:20

rank-order [1] 231:5

Rapid[2]

45:3 76:2rapidly [3] 90:20 226:15 289:

20

Rappaport [14] 2:30 3:8 5:8,9,10 10:16,19 11:1 16:2 183:

6 311:4 344:16,20 365:9

rare [1] 34:6

rat [35] 42:8 43:5 46:8,17 48:17,19 53:6,21 54:5 55:1 59:9

62:16,21 63:4,8 65:1 77:4

120:21 123:15 139:3 157:6

163:16 187:19 188:22 189:5,

6 191:5 192:9 256:20 257:14

258:8,20 269:3 298:14 314:1

rat-forebrain [1] 154:3

rate [10] 87:4,16 99:10,14 109:1 137:11 166:19,22 222:8

360:3

rate-limiting [1] 339:10

rates [3] 101:11,18 195:13

rather [9] 30:13 39:6,15 54:

11 72:7 198:10 250:8 320:15

336:6

ratio [1] 234:13

rational [1] 256:1rats [44] 11:7 55:10 67:7 101:

5,10 112:7,16 113:6 118:19

119:15,16,17,19 123:6,10

126:5,7 128:13 133:20,21

136:9 162:16 192:2 193:5211:1,11,21 212:4 214:2,6

257:2,4,13 258:10 259:5,8,10,

10,11,13 283:18 296:19 298:

12 362:9

re-discuss [1] 183:8

re-dress [1] 303:17

re-reading [1] 208:19

reach [4] 127:6 151:4 206:19

258:15

reached [2] 215:12 233:2

reaching [1] 232:12

react [1] 73:15

reaction [4] 26:9 80:15 98:9

115:16

reactive [1] 271:13read [4] 218:5 282:8 309:10

333:20

readily [2] 23:2 97:9

readings [1] 212:9

ready [2] 221:9 286:5

real [10] 97:2 102:1 135:6 172:11 179:8 224:15 254:8,19

265:8 266:11

realities [1] 222:20

realize [3] 148:11 152:5 178:

22

realized [2] 143:3 178:8

really [93] 15:6 50:9,14 51:1

55:5 104:6,11,13 110:20 113:

4 114:6 118:1 120:22 122:15

123:16 128:11 133:19 134:

12 135:11 139:17 143:9 145:

14 147:20 148:1,22 150:19

151:9 167:9,21 179:9 180:6

181:13 208:15 210:15 211:1,

4 213:14 214:3 215:1,12,17

251:7,22 252:6 254:13 255:

12,14 261:8 270:1 271:7 274:9,16 280:13 281:14 282:10,

15 285:3 287:10 288:18,22

290:1,9 297:22 302:15,17

305:13 308:13 315:6 317:15

319:20 320:1 321:15 326:16

329:8 335:19 338:11,16 341:

6 342:15 343:21 345:2 348:8

349:8 354:13 355:19 356:4

357:2,6,12 359:19 360:11

363:10,19

reason [9] 90:15 115:14 156:

15 212:16 218:14 223:1 229:

20 230:3 355:9

reasonable [4] 20:10 341:13

348:12 356:6reasons [6] 22:3 56:7 242:3

268:16 355:11 364:16

reassess [1] 20:14

reassure [1] 306:15

reassuring [2] 354:5 363:12

recall [8] 70:17 130:4 222:17287:20 295:5 321:14 323:5

344:17

receive [2] 185:2 200:22

received [5] 38:1 221:19 232:

17 272:21 365:11

receiving [5] 271:12,17 327:

19 350:6,8

recent[7]

14:2 34:5 208:9240:22 247:8 301:6 343:14

Recently [8] 12:11 19:1 65:

18 88:14 90:10 91:4 294:17

314:3

receptor [33] 18:19 42:12 43:

8 46:1 48:11 50:22 51:19 66:

20 71:9 106:8,16 116:19 148:

8,16 149:1 154:13,16 155:2,

18 161:14,21 162:1,5 174:19

175:5 176:19 177:3 178:1

186:19 240:13 283:4 297:2

338:9

receptors [12] 18:3 19:13,19

39:11 75:18 76:14 98:3 148:

18 175:2 210:3,7 297:4recessed [1] 217:3

recognize [4] 143:1 202:1

284:22 286:9

recognized [2] 103:18 178:2

recognizing [1] 317:17

recommend [2] 57:1 341:15

recommendation [1] 248:19

recommendations [3] 15:2

30:2 244:10

recommended [5] 25:14 46:

17 207:3 222:3,13

recommending [1] 334:5

protocols - recommending



reconsider [1] 303:5

reconstruction [1] 347:15

reconvene [2] 333:3,7

record [6] 9:6 10:9 326:13

328:8 330:1 332:21

recorded [1] 121:19

recording [1] 122:1

recover [1] 125:1

recovering [1] 250:12

recovery [2] 130:2 275:18

recreational[1]

226:17recreational-use [1] 226:9

recruiting [1] 201:4

recurrence [1] 247:1

red [3] 48:12 168:15 219:13

reduce [7] 89:5 188:12 236:8

238:6 242:14 244:2 273:6

reduced [5] 36:2 77:6 89:1,

10 276:12

reduction [1] 322:17

reductions [1] 275:7

redundant [1] 113:15reemphasize [1] 340:12

refer [2] 111:1 228:14

referenced [1] 246:1

references [1] 141:5referred [3] 16:22 36:20 115:

14

refining [1] 349:7

reflect [2] 187:11 204:17

reflected [1] 216:17

reflecting [1] 48:21

reflects [2] 27:15 223:18

reformulated [1] 222:18

Reformulation [1] 222:19

refuge [1] 126:17

refute [1] 162:9

regard [3] 39:20 67:21 165:3

Regarding [18] 3:9 12:18 14:

20 15:2 16:4,7 24:10 27:1244:14 49:21 130:21 213:6

220:2 224:14 244:5 248:16

341:5,12

regards [5] 45:20 56:2 227:1

297:2 319:15

regimen [8] 42:17 54:13 60:

14,20 67:15 71:11 309:18

311:14

regimens [2] 33:18 349:6

region [10] 81:21 82:6 94:14,

17 96:7,10 200:18 225:16

226:7 278:8

region-specific [1] 299:14

regional [7] 34:20 114:9 246:

18,21 262:2 279:19,21regional-anesthesia [1]

280:11

regions [4] 51:2 77:18 96:4

140:8

registry [2] 199:1 316:12

regressive [1] 144:17

regular [1] 212:21

regulated [2] 9:14,20

regulation [5] 27:16 29:2 30:

13 31:18 292:1

Regulations [2] 24:15 31:6

Regulatory [8] 3:9 13:16 16:

4,7 27:22 32:19 68:4 223:20

Reid [3] 4:13 249:13,15

reinfarction [1] 247:8

reinforcement [2] 291:2,6

relate [8] 83:3 105:3 133:17

163:14 169:22 281:10 289:5

318:9

related [15] 16:20 32:19 34:

12 37:11 38:14 102:1 241:4

244:19 250:2 261:21,22 262:

7 325:11 331:17 348:21relates [2] 269:22 288:10

relation [2] 71:2 133:17

relationship [7] 88:6 144:8

218:17 234:19 237:4 256:10

278:22

relationships [4] 219:5,7

342:16,17

relative [6] 19:4 76:4 205:4

223:14 246:5 266:22

relatively [19] 14:1 17:2 27:

13 65:9 85:4 121:9 136:21

142:14,19 144:4 152:22 164:

15 167:10 170:6 204:14 261:

2 263:10 305:7,9

relatives [1] 220:15relaxant [1] 184:14

relaxation [3] 252:16 253:10,

22

release [16] 17:18 130:21

161:1 226:4 227:9,10,12,12,

14,14,22,22 228:8,8,10,10

released [1] 226:14

relevance [6] 11:11 40:5,15

186:16 239:12 350:4

relevant [13] 56:16 102:5 118:8,9 125:12 188:2 236:5 250:

5 277:21 280:9 329:9 333:12

337:5

reliance[1]

242:18relief [1] 21:14

relooking [1] 202:12

rely [1] 30:13

remain [4] 23:13,19 242:22

270:9

remainder [1] 14:13

remained [1] 90:8

remains [3] 124:18 241:16

245:1

remarkably [1] 80:14

Remarks [2] 3:7 10:22

remember [4] 126:16 203:18

204:10 269:17

remembered [1] 63:2

remifentanyl [1] 323:11reminder [1] 224:13

reminds [1] 124:14

remote [1] 25:11

removal [1] 43:14remove [5] 94:6 95:7 128:3

161:19 199:10

removed [6] 51:10,11,13 91:

18 223:1 251:10

removing [1] 361:7

renal [1] 110:6render [1] 225:2

repair [5] 240:11,16 286:12

332:7 362:20

repairs [1] 196:15

repeat [2] 311:10 354:18repeated [12] 23:9 53:12,20

59:12 72:2,6 105:17 286:16

319:8 329:2 340:15,22

repeatedly [1] 142:5

repetitive [1] 144:5

replace [1] 255:13

replicate [1] 149:12

report[8]

42:13 55:9 61:1763:22 64:16 65:13 66:8 145:

2

reported [25] 9:12 37:13,16

39:5 44:5 46:7,10 53:14 57:

22 59:4 60:4,14 62:6,9 63:11

65:5 67:12 72:21 73:6 88:14,

18 90:10 91:5 100:11 189:2

Reporting [2] 36:21 37:1

reports [7] 11:9 26:21 38:17,

22 39:8,9 235:19

represent [5] 9:22 22:21 43:13 224:10,15

representation [1] 101:19

Representative [4] 2:15 8:

22 9:19 340:21representing [1] 44:20

reproduce [1] 82:16

reproduced [1] 64:3

reproducible [1] 46:9

reproduction [2] 25:3 26:4

Reproductive [1] 161:10

request [1] 248:20require [17] 15:17 27:17 32:

14 56:7 58:12 92:21 170:13

184:4 191:5 216:11 223:10,

20 270:15 332:10 340:16

348:1 351:6

required [14] 28:12 29:6,11

31:18 32:2 33:8 60:21 74:1385:15 95:4 144:5 156:17 184:

8 214:21

requirement [2] 29:10,15requirements [4] 27:22 34:3

185:7 190:7

requires [4] 24:16 273:17

279:4 337:8

requiring [1] 273:19

rescue [1] 126:17

RESEARCH [24] 1:3 5:16 9:

15 12:2,3 29:18 30:6 32:14,

15 35:14 44:21,22 45:2,9 48:

2 65:17 97:6 147:16 266:9

298:7 310:16 313:6 325:11

333:1researchers [1] 16:11

researching [1] 348:16

resection [1] 21:8

reside [1] 220:9

resident [2] 108:17 250:8

resilience [1] 357:21

resolve [1] 97:6

resounding [1] 226:2

resources [4] 134:3 265:7

326:9,22

respect [2] 10:10 140:22

respiratory [2] 120:11 196:7

respond [9] 93:14 102:10

158:1 240:13 275:2 277:12

283:10 342:1 343:11

responds [2] 323:21 324:3

response [33] 11:22 36:2 41:

1 45:3 50:9 51:16 61:2 64:21

72:14 91:16 92:12 130:20

131:4 154:1 158:5 186:5 194:

11 201:19 281:18 287:18

308:7 310:5 317:10,11 328:

11,16,18 335:20 336:2,5,10337:7 338:7

responses [9] 31:3 35:21 61:

3 62:4 67:22 248:10 337:11

341:10,11

responsibility [3] 221:13,16

225:5

responsible [3] 182:5 232:4

237:22

responsiveness [2] 154:13

172:4

rest [3] 98:9 167:21 177:6restraint [1] 261:12

restrictions [1] 265:18

result [5] 85:16 107:8 177:14

207:19 258:5resulted [2] 63:5 150:20

results [7] 12:11 44:5 62:20

128:14 157:18 177:14 353:

18

resumed [1] 217:3

retain [1] 18:11

retardation [2] 105:13,15

retested [2] 127:12,13

retrospective [1] 142:16

retrospectively [1] 359:14

retrosplenial [1] 258:1return [3] 216:22 247:15 315:

17

reversed[1]

295:3reversibility [2] 165:10,11

review [9] 13:16 45:22 46:3

100:19 185:16 227:17 243:5

250:14 359:14

reviewed [8] 47:12 49:20 135:

5 168:2 227:17 228:5,6 245:

14

revoked [1] 31:3

revolutionary [1] 29:9

Rhesus [8] 48:19 49:8 65:21,

22 102:7 156:15 164:14 166:

8

Rheumatology [3] 5:11,20 6:

2

Rich [1] 125:15rid [2] 113:16 161:19

rigorous [1] 34:5

rise [2] 29:1 170:6

rises [1] 186:5

risk [44] 20:10,11 22:4 24:22

25:1,7 26:1,8,13,20,22 55:19

72:1 104:3 228:15,17 241:18

246:4,6 247:13,21 248:1,15,

18 267:2 271:21 278:5 286:

14,19 287:9 293:5 313:5 329:

6,14 330:18 331:10 339:18

344:10 346:22 347:1 350:1

reconsider - risk



362:5,8,15

risks [9] 15:19 26:13 223:14

227:11 228:12 364:3,7,13,15

road [1] 181:13

Robert [1] 2:29robust [2] 83:6 361:1robustly [1] 77:3

Rockich [1] 115:21

Rockville [2] 1:10,11

Rod [1] 229:7

rodent[25]

11:13 12:5,16 35:17 61:18 76:5 90:18 93:15

107:15 150:2 156:18 157:10,

19,22 158:4,16 160:7 170:1

177:20 182:10 204:12 207:6

293:17 294:5 315:5

rodents [5] 11:21 17:3 151:

13 277:16 290:19

Roderic [1] 4:7

role [8] 9:21 27:15 28:21 46:2

148:9 191:12 221:14 293:19

room [15] 133:12 136:5 137:

13 148:8 178:22 187:12 188:

11 189:10 249:21 253:18

301:21 330:17 334:2 358:18

363:18ROSTER [2] 2:1 6:21

roughly [3] 94:2 99:14 264:

12

route [2] 23:6 304:11

routine [1] 188:13

routinely [2] 108:10,20

row [1] 95:20

RSV [2] 271:14 347:17

Rubsamen [5] 4:13 249:13,

14,15 256:7

Rudin [1] 64:15

rule [4] 25:14 31:18,22 32:2

rules [3] 29:14 243:13 314:16

run[1]

265:9running [1] 10:20

Ruth [1] 317:2

Ssacrificed [1] 114:10

safe [6] 24:10 28:12,13 186:8

242:12 278:19

safer [6] 26:15 27:2 40:11

307:21 309:18 311:14

safest [2] 302:12,22

safety [26] 20:9,15 23:21 28:8

29:4,20 31:9,20 32:3,6 33:11,

18,21 40:1 44:10 97:14 206:

11 223:18 227:8,11,15 228:1,

3 248:20 304:8 322:6salicylates [1] 241:19

saline [14] 43:7 53:11 59:12

80:21 94:13,14,15 95:10 96:

12,16 124:7,8,9 284:5

saline-treated [2] 77:12 87:9

same [69] 21:17 23:8 29:3 30:

3 69:21 70:1,5 78:1 80:16,19

93:14 94:13 95:16 99:21 122:

10 123:6,7 127:11 128:7,14

130:5,10 141:12 143:15 150:

15 156:9 157:19,20,21 158:

12,13,17 159:9 165:3 169:6,9

170:11,14,16,19 172:1 191:5

207:17 214:5,22 216:2,11

223:3 227:21 231:17 258:6

268:10 278:3 284:9,10,11

285:21 288:2,3 295:8 296:14

297:4,11 301:5 305:14,18

314:11 354:20 362:12

samples [2] 168:19,21

San [1] 248:8

Sands [1] 191:16

satisfactory [1] 97:15

saturation[6]

90:6 137:7,7167:19 168:9 190:3

saturations [2] 100:12,14

saw [9] 111:9 152:9 206:8

215:14 301:22 335:15 354:7

362:9 363:9

saying [6] 206:11 297:15 302:

16 310:17 342:10 356:22

scale [2] 48:19 92:15

Scallet [4] 46:10 59:6 72:21

149:19

scans [1] 270:13

scattered [1] 81:3

scenario [3] 60:6 73:1 244:

20

scenarios [1] 292:3scene [1] 123:14

scent [1] 285:17

schedule [6] 147:5 182:17

219:16 222:5 225:6 301:21

scheduled [1] 307:15

schedules [1] 16:1

scholarly [1] 250:14

Schoo [1] 4:9

School [4] 4:18 7:15 211:16228:22

Science [6] 11:6 42:3 53:7

102:1 306:4 330:7

Sciences [12] 8:17,19 12:13

29:18 30:3 45:1 46:6 58:4149:19 157:3 168:1 175:10

scientific [2] 93:9 309:6

scopolamine [1] 143:2

score [5] 197:22 263:8 345:

21,22 346:1

scores [1] 123:2

Scott [2] 4:11 243:16

screen [1] 220:13

se [5] 141:3 215:9 261:21 317:

16 338:9

search [2] 141:4 164:10

Seattle [1] 8:4

second [16] 17:5 25:8 61:10,

18 91:3 94:2 100:10 112:17

124:13 142:9 269:17 324:6325:8 332:9 356:20 365:15

Secondly [1] 133:14

seconds [1] 219:12

Secretary [2] 2:3 29:14

secretase [1] 238:16

section [7] 21:18 31:7 49:15

94:6,19 95:7 350:19

sectioned [2] 78:4 352:21

sections [5] 48:13 81:12,14

82:6 352:16

secured [1] 32:22

sedate [2] 188:9 202:22

sedated [1] 272:6

sedating [1] 143:6

sedation [12] 35:2,9 40:3 86:

10 135:17 143:2 197:16 273:

20 283:6 308:11 322:17 328:

5

sedative [7] 11:15 12:19 19:

13 34:16 135:22 273:13 349:

6

sedatives [1] 22:7

see[165]

43:12,12,16 49:1054:7 67:6,8,9,18,19 70:3 71:

5,18 77:13 78:3,19 80:11,17

81:3,18 94:10 96:16 109:2,

14,18 115:8 119:17 120:8

121:21 123:4,17 124:12,19

127:2,20 129:20 130:6 131:7

132:2,9,10 133:7 136:21 137:

4 138:3,7,12 139:8,10 145:2

149:14 150:8,17 151:18,21

152:13 153:7 154:4,9,14 156:

5 157:7 159:1,21 160:8,21

162:8 165:15 168:4 169:1

170:3,5,8,10,15,19 171:6,15,

16,19 172:8,11,16 173:2 174:

5,20 175:1,20 176:1,5,6 178:18 179:12 185:18 187:11

188:20 189:21,22 192:5,13

195:11 197:21 198:3 202:2,

16,19 205:8 206:5 207:4 209:

10 210:8 211:5 216:18 219:

11,13 220:12 223:16 229:19

236:14 237:8 238:5 244:17,

20 246:14,19 247:4 251:22

252:13 255:4,6 256:1 262:13

263:10 264:5,10 266:10 268:

5,5 288:2,4 289:11 295:9,22

296:13 297:11 299:14 301:9,

17 321:15,17 328:12 332:5

336:1 346:13 347:7,9 349:4352:11 354:4,19 355:7,12

356:7 357:1 365:2

seed [1] 201:10

seeing [16] 42:2 43:1 105:19

151:12 152:15 156:2 159:11

160:18 203:17 248:4 276:18

277:1 310:16 330:15 334:8

335:10

seem [7] 146:7 179:17 181:7

216:3 289:4 330:5 361:1

seemed [2] 216:9 362:10

seems [28] 17:2 69:22 72:8

113:19 150:4 177:1,19,20

179:11 203:21 205:6 246:21

256:1 263:4 269:8 278:13284:2 289:8 293:19 297:3

298:15 299:1 305:12 320:11

325:1 354:22 356:11 360:6

seen [23] 11:20 12:16 36:16

108:5,12 112:2 129:2 139:5

142:5 148:17 151:4,15 181:

14 191:16,17 211:10 224:14

226:7 248:15 275:17 276:7

319:15 329:8

segments [1] 33:16

seizures [1] 197:18

select [2] 225:20 351:18

selected [3] 31:19 262:19

360:19

selecting [1] 357:5

selective [1] 281:6

self-signaling [1] 107:6

Senior [2] 8:6 13:7

sensation [1] 35:15

sense [16] 70:4 134:7 157:12,

16 164:19 204:21 206:11

234:7 278:14 295:2 301:11

304:14,15 325:18 335:4 364:19

sensitive [26] 56:5,10 97:3

103:3,4,7,9 112:14 143:13

144:20 150:4 154:5 162:17

163:4 164:6,9 176:3,10 178:

11,14 179:9,11,17 278:10

285:6 363:1

sensitivity [8] 103:1 122:9

163:13 164:8 178:5 179:10,

13 204:17

sensory [6] 282:20,22 283:5

284:13 285:16 287:18

sentinel [1] 186:13separate [3] 210:11 258:8

269:6separately [1] 209:17

septic [1] 184:8

sequelae [2] 142:2,3

sequence [1] 173:11

serial [1] 94:18series [5] 98:5 204:19 230:19

246:7 251:1

serious [2] 26:14 302:13

seriously [2] 222:3 239:15

serum [2] 338:1 351:1

serve [2] 240:2 249:21

SERVICES [1] 1:1

session [6] 217:1 218:11 243:

13 281:20 289:7,8set [9] 16:12 28:13 120:1 148:

3 165:11 196:22 224:12 236:

2 353:7

sets [1] 288:18

setting [22] 14:6,21 15:8 22:

20 55:5 57:4,8,15 68:3 117:

22 120:17 136:5 137:13 149:

13 189:11 271:4,6 299:4 323:

13,13 334:12 342:14

settings [1] 313:3

setup [1] 286:1

seventies [1] 184:2

several [26] 30:15 34:9 42:2,16 67:12 76:7,12,13 85:7 93:

21 148:1 150:7 153:21 156:7164:3 178:2 182:7 185:6 200:

17 222:13 227:4 235:19 264:

8 272:10 358:11 361:11

severe [7] 105:12,19 106:1

121:14 142:3 223:5 303:9

severely [4] 105:16 119:21,

21 273:10

severity [1] 122:13

sevo [3] 255:14 355:4,14

Sevoflurane [19] 31:11 201:1

213:5,12,16,18 214:6 244:19

250:22 253:4 296:13 298:3

risk - Sevoflurane



318:19 320:6,18 337:18 338:

13 353:20 354:3

Shafer [108] 2:2 3:3 5:3 7:2,2

11:2 16:2 40:19 41:2 68:15

70:21 71:16 72:18 73:11,22

99:6,22 100:17 102:10 103:

13 106:2 107:18 146:22 147:

12 182:15 198:21 203:4 205:

19 214:6,8 216:20 218:3 224:

17 229:6 234:15 239:18 243:

12,18 249:12 256:7 260:16266:13 277:11 278:1,12 279:

14 283:9,12 286:7 288:7 294:

13 295:9,13 297:14 301:8,15

305:18 306:17 309:3 310:4,6

311:6 312:7,13 313:19 315:8,

12,17,22 318:1 319:10 321:6,

21 322:20 323:16 324:21

326:6 327:5 328:7 329:13,17

330:10 332:14 333:7 334:4,8

335:13 339:21 340:11 341:1,

22 342:18 345:11,14 346:17

349:15 353:10,16 354:1,7

356:9 357:15 358:8 361:4

362:2,16 365:15,18

Shakes [1] 301:14sham [5] 135:8,10,11 139:9

321:10

shams [1] 139:22

shaped [1] 96:7

share [2] 244:4 266:16

sharp [2] 64:5 150:3

shebang [1] 346:6

shed [1] 146:13

shock [1] 184:8

short [8] 133:15 142:19 144:4223:16 224:12 259:20 360:

16,22

short-acting [1] 282:1

short-term[4]

251:17 254:18255:19 290:15

shorter [3] 136:7 172:22 178:

16

shortly [3] 6:21 59:18 169:17

shot [1] 133:13shouldn't [1] 229:20show [36] 36:4 78:2,11,12,16

90:12 93:6,10 104:18 113:18

120:17 126:22 151:2 155:9

166:4 167:18,19 171:2 191:3

194:18 196:1,12,17 199:22

202:13 233:16 234:4 256:22

265:2 266:4 278:18 295:7

309:12 310:1,3 357:21

showed [31] 35:21 64:5 77:22 98:2 99:9 117:8,11 128:

13 140:1 152:6 155:5 175:4

186:1 187:3,5 189:17 193:13

198:7 204:11 211:1 213:15

231:17 236:20 256:18 266:6

281:21 296:15,18 343:17

346:7 353:8

showing [31] 23:13,20 78:21

80:21 90:5 94:16 95:9,13 96:

3,6,9,11,13 99:16 124:15 130:

8 154:12 155:12 158:12 160:

10 161:12 224:12 232:17

233:16 246:6 262:20,22 274:

14 276:22 296:4 343:12

shown [24] 25:4,6,19 28:12

40:11 50:7,19 67:7 90:1 94:9

115:3 116:17 117:4 171:8

187:6 192:12 193:18 194:20

208:10 211:11 237:2 269:6

278:6 304:14

shows [6] 27:7,21 36:2 174:6

231:14 286:20

shrink[1]

18:12shunt [1] 21:10shunting [1] 21:7

sick [1] 195:11

sicker [1] 287:5

sickest [1] 344:11

sickle [1] 277:3

side [6] 80:15 124:7,11 316:2

322:6 350:10

sign [1] 134:19

signal [15] 40:1 116:7 321:7,18 323:3,4 325:2,5,6 330:3,3

347:9 354:4,7 363:12

signaling [3] 18:2 338:11

339:11

signals [3] 97:19 98:5,20signature [1] 289:5

significance [2] 41:21 125:4

significant [28] 30:21 37:18,

22 42:14 85:22 86:12,15 87:

2 88:7 89:4,9,13 91:22 92:5,

9 108:5 130:7 131:2 132:20

138:9 168:4 234:6 247:13

258:18 268:15 272:8 321:15

331:10

significantly [6] 140:12 229:

4 258:2,19,21 259:12

signs [5] 78:18 121:2 131:7

137:9 295:22

silver[6]

77:21 123:20 167:2172:14 175:12,16

similar [25] 12:16 43:2 44:5

62:4 63:10 90:11 117:9,13

130:22 138:18 143:17 158:2

209:10 211:2 251:2 258:12

260:4,8 263:10 273:12 279:5

282:14 291:5 338:13 355:13

Similarly [2] 35:6 318:22

Simone [13] 2:33 3:11 5:22,

22 13:20 16:6,9 40:19,21 41:

2 50:10 71:6,12

simple [6] 118:5,11 221:7

230:20 242:12 285:15

simplistic [5] 109:7 112:4

210:1 286:10 296:8simply [14] 51:11 52:10 54:11

55:7 57:11 96:21 124:3 159:

1 162:21 210:10 275:11 304:

16 317:13 354:19

simulate [1] 284:6

since [11] 11:18 45:7 46:13

66:17 70:10 134:1 148:3 225:

13 226:21 250:7 281:16

single [24] 53:12,17 59:14 60:

9 71:22 72:7 85:11 86:9 100:

4,4 103:21 104:2 134:19 150:

17 188:8,15 190:1 212:18

231:8 268:11 279:13 293:2

336:6 338:21

sites [3] 267:10,11,12

sits [1] 192:1

situation [10] 26:14 37:8 40:8

159:18 162:3 163:17 169:22

180:1 294:7 331:5

six [3] 32:10 219:17 246:12

six-month [1] 31:14

sixth [1] 151:20

sixties[1]

184:2size [6] 110:19 111:9 246:8

339:5 351:19 356:6

skill [1] 276:4skills [1] 199:22

skin-breaking [1] 317:3

slap [1] 143:4

sleep [1] 143:5

sleeping [1] 28:18

slice [2] 43:5 361:7

slices [4] 54:18 268:1,12 287:

21

Slide [194] 16:18 17:14 18:21,

22 20:7 22:15,18 23:8,10,11,

16,17 24:13 27:6,7,20 33:1

34:14,18 35:5,11 36:14 38:11 39:7,12,22 41:10,22 42:21

43:16 44:11 45:18 47:10 48:

7,8 49:15 50:1 52:4 53:15 54:

3,19 55:15 58:22 59:20 61:5,

15 62:14,19 63:12,21 64:14,

19 65:11 66:11 69:18 74:10,

17 75:15,19 76:8,16 77:1,9

78:7 79:9 80:8,18 81:8 82:13

83:9 84:16,19 85:1,18 86:6

87:6,17,22 88:9 89:15 91:2

92:13 93:16 94:20 95:14,19

96:2,14,19 97:8,21 98:1 100:

19 108:3 109:9 110:7,22 112:

1 113:10 114:13 115:19 117:1 118:3 119:8 120:19 122:5

123:12 124:5,17 126:1 128:

16 129:3,19 130:13 131:5,11,

20 132:7,13 134:5 136:15

137:14 138:16 139:1,11,13

140:18 142:8 143:18 144:21

145:12 148:6,14 149:6 151:6

152:19 153:13 154:2,12 155:

3,20 156:12 158:18 160:5,12

161:7 162:10 163:18 166:6

168:7 169:18 172:6,13 173:5,

18 174:14 175:7,8 176:15,22

177:12 178:7,20 181:11 182:

3 183:15,20 184:10,17 185:9,

21 186:12 187:1,8,16 188:3189:3,15,20 190:21 191:15

193:6 194:13,16 195:9 196:

10 197:7,20 198:11 199:13

200:8 201:12 202:8 231:1

slides [5] 23:9 27:8 114:17,

17 148:5

slight [2] 64:1 122:2

slightly [4] 49:12 96:7 186:4

318:14

Slikker [33] 2:31 3:23 5:14 13:

9 14:10 48:3,8 65:16 66:10

69:11 99:15 147:13,14,20

182:15 203:8 204:9 206:14

214:17 215:17 266:22 267:6

270:8,15 288:15,21 289:11

291:22 293:6 294:4 340:3

356:9,10

Slikker's [1] 256:15

slow [5] 128:14 130:2 170:6

262:16 361:14

slowly [3] 53:1 92:20 93:1

small [15] 75:2 104:3,9,14,17

107:14 109:8 110:2 120:20121:6 187:18 195:11 225:11

246:7 356:12

small-size [1] 132:22

smaller [3] 70:5 133:3 141:9

smell [3] 284:19,20,20smile [1] 301:19

smoothed [1] 253:15

Snodgrass [16] 2:23 8:10,10

106:3,4 107:4 292:20 300:18

311:21 313:10 322:20,21

328:1 337:14 339:4 340:13

snort [1] 226:10Society [5] 7:11,16 198:19

199:3 281:20

sodium [16] 82:21,22 83:21210:13 279:16,17 280:1,15,

18,19 281:3,4,9,12 327:8,10

solely [2] 30:13 208:22

solubilized [1] 84:11

soluble [2] 84:9,10

solution [2] 97:10,15

solutions [1] 97:9

solvent [3] 28:6 83:5 84:14solvents [3] 83:2 84:4 250:10

solving [1] 145:8

somebody [2] 141:20 265:12

somehow [2] 131:18 270:6

someone [1] 335:3

someplace[1]

338:10sometime [1] 180:13

sometimes [7] 84:8 105:12

138:12 209:22 284:16 305:3

339:16

somewhat [4] 106:22 318:16

347:13 351:10

somewhere [3] 76:6 154:21

163:4

soon [2] 137:20 168:1

sophisticated [1] 186:9

Soriano [42] 2:10 3:26 7:13,

14 13:9,11 14:10 22:14 36:7

53:5 69:13 89:18 109:12 140:

19 146:12 182:22 183:5 203:

4,8 208:4 266:22 271:19 273:9 281:18 286:9,18 298:6 302:

6 303:3 305:2,18,21 312:4

313:16 317:13 319:20 322:

14 334:13 343:11 344:19

345:3,18

Soriano's [1] 271:8

sorry [1] 345:11

sort [40] 151:8 153:14 155:4157:13 160:13 161:1 164:19

169:21 170:14,19 173:20

175:10,15 180:21 181:12

203:22 204:18 206:10,15

Sevoflurane - sort



216:13 250:20 265:15 270:

21 273:22 274:9 293:18 301:

11 309:5 316:2 319:7 336:6

342:19 347:3 348:15 356:10,

14 359:19 361:4 363:7,11

sought [1] 142:4sounds [1] 282:16

sources [1] 182:9

southwest [1] 225:11

span [1] 119:14

spans[1]

17:6spare [1] 21:1

spared [1] 224:7

sparked [1] 55:16

sparse [3] 81:3 87:13 94:16

spatial [1] 126:5spatial-reference [2] 258:22

259:9

SPEAKER [10] 2:26 107:20

147:12 182:22 218:15 224:

18 229:7 234:17 249:13 256:

8

speakers [9] 182:21 219:9

266:14 282:10,18 283:9 301:

9 309:7 365:13

speaking [5] 20:18 175:11219:8 271:19 344:1

speaks [1] 340:14

Special [4] 83:13 222:5 235:11 327:22

specialized [2] 190:1 223:10

specialty [1] 308:15

species [38] 17:3 48:22 49:14

56:2,5,8,11,12,13,20 58:10

61:10,18 67:7 76:4 101:9,10,

11,13,20 102:8 112:5 113:5

136:11 162:13 166:10 190:

22 191:20 207:4,9 215:7 271:

4 290:11 291:9 315:1,2 357:

7,8specific [22] 9:10 23:12,18

24:6 81:5 225:7 244:6 270:

17 276:13 282:20 283:6 294:

20 297:7 303:4 334:22 348:

21,22 349:5,8 358:12 359:4,

17

Specifically [15] 23:4 29:12

34:12 38:19 48:12 49:18 211:

4 225:4 234:5 245:5 246:8

280:20 317:3 318:3 360:21

speck [1] 94:10

spectrum [1] 337:19

speculation [1] 69:15

speed [1] 276:12

spend [1] 125:22spending [1] 306:4

spent [2] 128:5 244:11spherical [1] 78:21spinal [11] 200:22 247:13 278:4,4,8 280:2,2,19,21 329:6

349:20

spoke [4] 162:11 179:19 181:

1 193:9

spoken [1] 292:7

sponsor [2] 33:7 218:18

sponsor's [1] 218:21

sponsored [1] 198:17

sponsoring [1] 239:22

sponsors [3] 27:18 32:15 57:

2

spontaneous [2] 258:2 259:

5

spontaneously [1] 254:20

spot [1] 128:7spots [1] 43:11

spread [1] 225:17

sprinkling [1] 77:14

spurt[4]

17:1,4 76:1 111:2spurts [1] 110:15

Srinivasa [2] 2:9 6:3

St [3] 4:5,6 84:22

stability [1] 57:10

stabilize [1] 98:15

stable [2] 164:2 206:19

Staff [1] 8:7

stage [14] 14:7 16:13 102:18,

19,20 103:9 115:6,7 120:1

148:3 164:6 170:16 214:22

332:9

stages [4] 102:16 164:17 178:

9,12

stain [5] 77:21 167:2 172:14

175:13,16staining [13] 43:10,20 77:22

80:9 81:1 87:12 95:22 96:5

123:20,20 137:22 138:13

354:17

stains [3] 77:21 78:2 123:21

stand [3] 40:1 263:9 322:14

standard [5] 78:9 159:7 170:

7 197:15 215:19

standpoint [3] 280:12 307:22 330:13

stands [1] 77:20

Stanford [1] 7:3

Stanford-Binet [1] 348:11

starred[1]

200:10start [21] 5:8 23:14 28:4 99:8

116:3,8 137:20 151:9,18 152:

15 156:5 159:21 164:11 176:

12 209:10 216:22 266:20

309:3 311:17 342:3,4

started [8] 85:19 129:18 143:

6 201:4 267:15,22 285:14,19

starting [4] 135:19 181:16

291:15 341:17

starts [4] 49:5 78:21 110:15

126:14

State [12] 7:9 58:16 98:4 130:

1 164:2 169:6,13 197:2 215:

12 233:5 307:7 342:9

state-of-the-art [1] 304:17stated [1] 31:8

Statement [13] 3:4 9:2,3 218:

16 219:3,8 221:20 222:2 309:

10,14,15,16 310:21

States [4] 27:19 235:4 325:16

351:15

stating [3] 31:6 206:1 332:20

statistically [2] 138:9 234:6

statistics [1] 224:13

status [1] 37:7

stay [2] 134:18 140:2

staying [4] 133:10 182:17

220:14 321:12

steady [1] 215:12

steady-state [1] 94:3

steep [1] 204:14

step [1] 339:9

stepped [2] 87:11,15

steps [3] 41:19 177:8 178:15

Steve [3] 7:2 183:5 351:13

Steve's [1] 337:6

Steven [2] 2:2 3:3

Stevenson[1]

316:10Steward [1] 228:19

stick [4] 238:4 239:3,3 278:21

stick-together [1] 238:5

stickier [2] 230:18 231:1

stickiness [1] 230:20

still [21] 40:7 65:3 73:20 89:7,12 98:20 103:6 116:12 127:9

143:19 176:17 188:20 202:3

244:14 253:4 273:14 282:7

287:11 314:12 346:14 363:4

stimulants [1] 327:18

stimulated [1] 273:22

stimulation [8] 18:1,18 68:19

193:9,21 194:10 283:20 317:

18stimuli [1] 240:18stimulus [6] 92:17 190:18

193:11 333:22 334:1,2

stop [1] 239:16

store [1] 134:12

story [2] 114:14 228:16

straddled [1] 198:2

straddles [1] 192:9

straggling [1] 82:1

straightforward [1] 261:3

strategies [2] 180:22 222:14

strategy [1] 359:11

stray [1] 198:3

street[2]

83:14,14stress [17] 35:21 36:2 181:7

186:4,5 194:10 201:19 240:4,

5 241:4,13 242:11,14,21 243:

4 260:10 293:19

stressful [2] 35:19 240:18stressor [1] 317:10

strictly [1] 37:1

striking [1] 247:6

stripping [1] 78:16

strive [1] 146:5

strong [1] 324:15

stronger [1] 29:1

strongly [2] 19:18 222:13

struck [3] 71:1 73:12 250:9

structural [1] 148:12structure [2] 74:16 251:3

structures [4] 79:1 81:19

138:4,21

struggled [1] 212:5

struggling [2] 103:15 127:9

stuck [1] 355:21

studied [39] 75:20 76:9,11,13

77:2 78:8 79:10 81:9 82:14,

19 83:6 85:3 86:7 88:1,10 91:

17,20 93:20 94:15,18 99:16

119:9 122:6 134:22 135:1

138:4 142:17 143:22 211:3

237:4 281:13 283:13 295:15

299:18 316:17 325:13 336:2,

4 358:5

Studies [173] 3:21 11:18 12:7,

12,14,16 13:2,6,8 14:6,18 15:

1 19:3,9 23:21 24:20 25:3,5,

13,21 26:4,5,10,18 29:9 31:

16,20 32:11 33:2,5,13 34:1

36:17 41:13,15 42:16 46:15

47:4,20,22 48:6 52:6,18 55:4

57:3,22 59:2 61:7 63:13 64:15 66:16,16 67:12,20 68:2,5,

11,18 72:21 73:2,13 79:13

90:19 97:11 101:21 102:4,5,

15 104:19 106:11 107:12,15

117:7 120:18 125:16 145:16

146:9,17 147:18 152:18 153:

12,16,17 158:9 160:14,14

163:12 166:8 171:3 175:11

180:9,15,19 182:2,10,11 184:

18 191:19 194:18 195:22

196:16,20 197:10 198:8 199:

8 202:18 208:9,15 210:6 211:

1,6 213:11,15 215:6,9 223:13

231:7 237:2 239:12,14 240:

22 248:20 256:3,22 262:1265:2 267:16,21 268:7,14,17

270:10 272:7 274:12 276:9

278:3 279:17 281:11 282:12,

13,14 289:21 291:12,19 292:

5,21 297:22 298:1 302:15

304:13 305:12 316:8 321:7

333:12 334:5,16 336:7 340:

18 341:17 343:13,20 346:2,3

349:14 350:21 353:8,18 354:

2 359:2 361:2 362:4,9 363:5

study [104] 25:19 29:16 30:1

33:8 36:4 44:15 47:7 56:21,

22 59:17 60:12 61:9 64:20

69:18 70:11 77:22 84:21 85:6 87:18 88:11,21 89:2 90:5

94:18 95:2,7 99:9 101:7 102:

15 103:20 115:1 117:10 118:

4,5 125:6 132:14 140:11 141:

6 142:9,11,16 143:20 151:1

159:10 160:16 165:17 166:3

188:4,6 197:17 199:11 201:9

204:12 206:9 209:12,14 211:

11 212:10 213:8,10 216:12

236:2 239:11,11 246:1,19,20

247:17,22 248:6 257:9 266:6

268:19 269:22 272:22 275:4

277:20 281:15 287:1,16 295:

7,8,11 296:17 299:9 316:6,9

320:17 322:13 327:4 333:22336:14 343:2,14,22 344:17

345:20 347:22 348:5 356:6

359:13 360:12 361:6,8

studyable [1] 101:4

studying [13] 84:5 85:19 88:4

119:2 275:10 277:17 334:21

335:9,22 336:10,22 337:3,5

stuff [3] 251:5 298:9,9

sub-anesthetic [2] 86:8,14

sub-MAC [2] 89:8,12

sub-optimal [1] 364:5sub-Q [2] 44:3 342:12

sort - sub-Q



subanesthetic [2] 190:15,19

subclasses [1] 327:22

Subcommittee [2] 45:10,14

subcutaneous [1] 59:11

subcutaneously [2] 42:18

64:18

subgroup [1] 195:14

subject [2] 17:16 98:19

subjected [3] 91:9 186:2 262:

9

subjects[1]

29:16subMAC [1] 190:15

submerged [3] 126:15 127:1,

14

submissions [1] 37:19

submit [6] 37:2,3,5 69:14 187:

9,18

submitted [2] 9:11 243:5

subplate [1] 102:6

subpopulation [1] 225:20

subpopulations [1] 347:19

subsequent [6] 45:8 105:10245:22 256:20 257:6 289:21

subsequently [1] 241:12

subsets [1] 293:13

substance [1] 107:17substances [2] 17:17 28:14

substantial [5] 20:1 204:4248:18 267:21 346:21

substantially [1] 222:10

subtle [10] 11:20 34:6 37:17

62:4 78:14 154:7 276:12,21

290:21 323:7

subtoxic [1] 70:7

subtype [1] 116:19

subunit [10] 148:19,20 154:15,15 155:2 161:4 174:19

178:2,4 338:7

successful [1] 137:4

successfully[1]

75:2succumb [3] 92:16,20,22

sudden [1] 242:2

suffering [4] 201:18 225:15

308:10,14

sufficient [10] 36:15 85:13

104:1 132:17 310:10 312:17,

19,22 313:5,11

suggest [7] 21:4 35:20 63:767:13 203:14 276:9 331:14

suggested [7] 54:21 144:8

206:4 235:20 279:19 298:21

330:4

suggesting [11] 20:11 62:2

179:20 233:1 255:1 259:1

261:7 277:15 294:19 325:9330:7

suggestion [2] 337:6 350:20

suggestions [4] 225:3 229:3

243:7 277:7

suggests [8] 17:17 53:22 60:

22 161:2 242:12 245:4 259:

17 274:16

suicide [6] 74:20 75:3 113:17,

19 114:1 115:15

suitable [3] 34:21 35:7 277:

16

suites [1] 108:10

Sul [5] 7:13 22:13 182:22 307:12 308:4

sulfonamide [1] 28:5

Sulpicio [2] 2:10 3:26

summarize [7] 41:12 175:15

176:16 177:13 183:16 199:

14 356:11

summarized [1] 318:5

summarizes [1] 59:21

summary [8] 175:8 238:12

248:11 259:4 322:10 363:13,22 365:1

Sunny [4] 184:19 308:17,18

356:21

superficial [2] 87:8 96:10superiority [3] 227:19 228:7,

11

supermaximal [1] 336:7supervisor [1] 5:19

supervisory [2] 14:4 45:12

SUPPORT [20] 1:4 2:4,12 5:4

9:9 29:1 46:15 47:3 57:10

162:9 174:2 182:9 184:9 270:

13 283:19 284:13 310:17,21

330:22 336:10

supported [2] 31:13 256:11supporting [1] 64:7

supports [2] 12:21 177:7

supposed [2] 287:22 345:12

Supreme [1] 30:10

surface [5] 57:18 98:3 336:6,

11 337:7

surfaces [1] 336:2

surgeons [1] 108:11

surgeries [5] 108:8 109:3

195:15,16 197:13

surgery [61] 20:19 21:5 22:10

36:9 60:5,21 73:7 101:2 184:

7,13 185:1 186:6,11 190:4,7,

8,14 192:15,16 193:10,19194:9 195:11,20 196:12 197:

3,3,9 201:20,21 207:16 234:

12 235:19,21 246:16 247:2,

15 251:9,12 254:5,10 261:17

262:6,10 264:11,20 286:21

287:6,7 307:18,19,21 316:9,

15,19 334:6 344:5 363:8 364:

16,19,21

surgical [28] 21:2,21 36:1068:19,22 95:4 100:21 144:2

165:4 166:13 190:12 193:11

196:8 206:20 247:16 261:22

265:6 302:19 317:18 330:18

332:7 333:22 343:15 355:9,

11,16 361:17 364:4surgically [1] 343:17

surprise [1] 321:8

surprising [1] 358:3

surprisingly [1] 39:2

surrogate [2] 270:11,14

Surveillance [1] 38:13

survival [1] 109:2survive [1] 195:17

survived [1] 75:8

susceptibility [4] 12:8 191:

14 192:18 193:4

susceptible [4] 63:9 130:5

141:22 338:17

suspect [2] 318:15 335:18

sustained [8] 226:4,14 227:

10,12,14 228:8,10 340:17

sustained-release [1] 228:

13

swallowed [1] 222:21

Sweden [1] 61:7

swelling [1] 174:9

swim [1] 126:13

swimmers[1]

126:7switched [1] 186:7

switchover [1] 314:5

symmetrical [1] 80:14synapses [5] 111:4,10 112:

14 113:14 116:8

synaptic [1] 55:13

synaptogenesis [32] 12:10

16:22 17:11 19:16 20:13 49:

1 76:3 85:12 92:18 93:1,5

103:3 110:15 111:2 112:6,10

113:1,5,12 114:6 122:14 123:

6 131:22 133:15 139:2 146:1

191:20 192:1,8 200:3 270:1,

3

synaptogenic [1] 18:5syndrome [10] 71:3,13 77:8

103:19 104:4 105:1,20,20

194:19 208:20

syndromes [2] 195:19 197:1

Synergistic [3] 242:16 327:

14 335:11

synonymous [1] 76:2

synthesis [1] 161:4

synthetic [1] 323:1

System [25] 36:21 38:3 76:13

110:10,11 116:17,18 124:22

147:14 148:8,10 149:5 153:

16 156:21 161:13 162:22

167:4 172:16 173:8 219:15220:22 240:8,9 267:9 270:5

Systems [10] 4:12 39:2 46:1,

2 76:10,12 138:11 243:22

262:22 297:2

Ttable [14] 5:6 18:22 22:17 23:

9 59:21 143:4 169:16 306:18

322:10 325:12 328:8 345:13

361:17 365:2

tables [1] 27:8

tag [1] 270:19

tail [2] 168:10 305:16tailor [1] 336:7

talked [11] 173:21 180:5 232:8 274:1 318:7,17 321:22 331:

8 359:17 362:19 364:6

tally [1] 263:9

tampering [1] 116:3

tank [1] 126:12

target [2] 152:21 153:8targets [1] 62:3

task [7] 126:20 127:11,21 162:

13 211:12,17 212:11

tasks [6] 126:3,5 165:16 212:

5 290:14 348:21

taste [2] 62:18 63:1

taught [1] 63:1

Team [1] 45:3

tease [1] 273:11

technical [3] 56:22 121:1132:18

technically [2] 66:9 121:8

technique [5] 167:5 184:12

185:3 309:22,22

techniques [5] 247:11 249:5

265:20 362:21 364:6

technologies [1] 255:9

technology[2]

244:1 361:13temperature [3] 137:12 292:

1,7

temporal [1] 96:3temporally [1] 37:11

temporarily [1] 222:17

TEMPORARY [1] 2:16

tend [4] 18:12 37:16,17 276:

11

tends [3] 37:11 137:21 262:5

tensor [1] 360:18

tentative [1] 96:20

teratogenic [1] 24:18

term [8] 93:22 164:13 166:10

175:18 179:11 300:22 342:

19 360:16termed [1] 18:8

terms [19] 37:22 38:9 50:21

51:14 58:17 68:6 114:3 174:

15 244:13 247:20 263:22

275:13 288:19 290:2 292:2

322:11 335:11 341:21 359:6

Terri [2] 247:17 248:6terrified [1] 301:17

test [9] 89:1 107:16 128:13

158:22 236:7 257:8 285:17

348:20 358:21

test-tube [1] 239:11

tested [6] 67:1 93:3,3 242:22

258:9 280:13testing [8] 54:16 127:18,18

243:5,8 282:5 285:14 348:14

tests [6] 211:8 264:18 285:15

291:3 352:13 354:14

tetracaine [2] 282:3,3

Texas [1] 8:12

textbook [1] 114:21

thalamic [4] 81:16 123:3,19

132:12

thalamus [12] 123:1 129:22

130:16 131:10 132:3 138:17

150:6 267:10,19 276:8 299:

18 300:1

thalidomide [2] 28:17 241:

19Thanks [3] 70:22 74:5 249:14

themselves [5] 10:8 34:9

143:5 336:7 349:21

theoretical [1] 20:8theories [1] 240:1

Theory [5] 240:5,5 242:6 255:

21 346:22

therapeutic [5] 97:1 223:15

227:8 339:16 353:3

therapies [5] 20:15 319:18

327:19 329:15,17

therapy [6] 27:3 40:11 125:2

subanesthetic - therapy



279:4 291:16 329:19

thereby [2] 17:12 24:1

therefore [13] 184:4 189:7

193:2 236:2 237:4 238:16

239:7 266:8 291:5 307:16

308:19 331:4,5

thinking [13] 121:13 183:18

186:7 201:15 276:6 281:5

293:7 297:7 307:2 321:11

327:17 351:13 359:20

thiopental[1]

23:4third [8] 17:7 25:8 49:5 60:17

69:4 90:15 92:14 94:2

Thomas [1] 2:8

thoracic [1] 273:18

thoraco-amniotic [1] 21:9

thorough [1] 281:15

thoroughly [1] 277:14

though [12] 104:11 124:18,19

199:9 216:3 263:17 265:11

304:21 323:14 332:12 338:

20 346:21

thought-provoking [1] 363:

4

thoughthe [1] 188:4

thoughts [5] 14:17 45:15 266:16 330:1 362:3

thousand [1] 251:13

thousands [3] 28:19 264:5

314:6

threat [2] 223:18 318:15

three [20] 49:7 68:15 69:4 76:

5 78:4 81:20 96:4 141:5 164:

11,17 171:3 175:14 182:20

244:6 245:7 323:18 332:11

337:12 338:22 339:6

three--and [1] 141:5

three-dimensional [1] 241:10

threshold[6]

60:22 64:8 85:2,8 179:1,1

thrombin [12] 240:10,13,15,

17 241:8,12,20,20,22 242:2,4,

10

throughout [8] 79:1 94:19135:18 165:6 190:4 292:8

325:16 352:4

throw [3] 133:6 203:1 250:20

thumb [1] 314:16

Thursday [1] 1:6

tickets [1] 250:4

tidal [1] 253:18tie [1] 175:3

ties [1] 250:5

tight [1] 57:9tightly [6] 114:11,12 137:9,11

139:4 170:8

time-concentration [1] 100:

8

time-consuming [1] 30:14

time-course [6] 157:19 159:

2 173:4 177:1 319:11 328:10

timeline [4] 10:18 112:8 192:

7 303:4

timelines [1] 112:2

timely [2] 97:7 361:20

Timing [5] 37:10 290:16 305:

2 341:8 364:17

Tinker's [1] 247:5

TIP [1] 343:14

tissue [9] 21:9 100:13,14 153:

8 223:6 240:11,16 241:10

303:17

tissues [2] 43:18 241:6

title [1] 65:19

titled [1] 33:11

titrated [2] 215:13,13

TIVA[7]

252:11 253:19 254:19 255:2,7,13,21

tocolysis [2] 350:15 353:20

today [59] 11:3 13:8 15:4,9 16:

12 41:11 42:2,6 43:3 50:19

52:13,20 53:6 61:8 67:6,8,9

74:6 110:9,13 111:4 112:3,7

113:6,16 117:6 126:2 135:2

140:20 146:13 209:2 213:21

220:2,8 222:2 224:21 230:1,

7 244:4 248:16 250:6,15 251:

21 255:1 261:2 263:19 274:9

275:1 276:7 282:11 283:3

288:19 308:22 321:1 323:19

324:12 330:20 359:19 365:

10Today's [4] 13:5 16:13 49:18

50:3

Todorovic [27] 6:14 11:9 13:

9 14:10 54:5 63:14 90:4 107:

20 146:22 187:7,17 189:17

192:4,12 198:7 202:11 203:8

208:1,7 256:18 258:13 266:

21 267:6 287:18 294:14 320:

16 322:5

Todorovic's [2] 187:2 353:

17

together [14] 122:16 149:20

161:8 173:20 182:11 185:17

199:1 203:13 213:11 238:4239:3,3 240:9 243:4

tolerance [4] 331:18,19 332:

2,5

tolerances [1] 28:13

tolerate [1] 287:7

tolerated [1] 203:22

Tom [2] 6:7 350:3

Tom's [1] 350:19

tonsil [1] 286:12tonsillectomies [1] 142:19

tonsillectomy [1] 141:8

took [14] 127:10 129:21 131:1

134:21 145:1 189:21 190:2

211:13 226:17 229:1 268:12

284:8 308:15,17tool [2] 180:7 205:15tools [11] 104:10 205:10 290:

10 291:6,9 356:21 357:5,6,12

363:1,2

top [3] 121:12 133:11 134:18

topic [7] 16:13 36:7 40:16 74:

11 261:4 264:2 343:1

topical [1] 34:20topics [1] 250:2

toppled [3] 98:8,9,16

total [7] 44:4 59:13 70:5 93:22 227:2 251:7 256:2

totally [2] 142:14 143:12

touch [1] 245:6

touched [1] 339:2

toward [1] 270:17

towards [2] 39:3 309:21

town [1] 225:11

Tox [1] 161:10

toxic [13] 193:18 209:15 213:

16 221:3 231:15 239:4 242:5,

18 263:5 265:16 295:8 320:

16 335:17toxicities [6] 34:22 35:8 56:

15 193:21 337:5 343:4

toxicity [17] 13:3 52:2 56:16

70:3,7,8 154:18 155:19 178:

6 195:7 231:22 240:3 242:13

263:11,13,18 334:19

Toxicological [16] 5:16 12:3,13 30:6 44:22 48:2 56:9,18

57:3 58:18 65:17 147:16 149:

18 157:3 167:22 175:9

Toxicology [5] 45:10 47:3,5,

12 56:5

traces [2] 82:2,4

trachea [1] 190:10

track [1] 358:22tract [1] 21:8

trade [1] 260:19

tragedy [4] 221:8,21 224:7

225:15

tragic [2] 221:7 228:16

training [2] 126:13 223:11

transcardiac [1] 120:15

transgene [1] 232:18

transgenic [4] 232:3,14 233:

7,20

transgenics [1] 232:20

transitional [1] 196:5translate [1] 315:3

translated[1]

180:19translational [1] 271:1translocate [1] 79:17

translocated [1] 98:10

translocation [1] 98:6

transmission [1] 193:16

transmitter [1] 76:10

transparency [1] 218:10

transparent [1] 218:8transposition [1] 197:13

trauma [1] 249:17

travel [1] 218:21traveling [1] 143:19

treat [3] 21:1 161:15 225:19

treated [11] 35:18 43:6,8 62:

11,16,21 63:3 169:9 171:19257:14 343:17

treating [1] 21:6

treatment [17] 15:20 21:7,10

54:17 65:4 80:11 81:21 154:

14 174:22 226:1 235:9 257:

16 258:4 259:7 271:13 308:

20 343:16

tremendous [1] 150:8

trial [19] 44:14 128:3 199:10258:15,16 272:15 273:1,8

343:21 344:18 345:1,6 347:1,

10,11 351:4 360:5 362:18,18

trials [7] 30:22 31:5 33:7,14

127:2 255:4 362:21

triangles [1] 168:15

tried [1] 286:2

trigger [10] 18:4 75:13 76:11,

15 85:13 86:12 97:19 98:21

299:1 359:19

triggered [1] 77:3

triggering [1] 107:1

triggers [2] 86:15 91:13

trimester[9]

17:7 24:22 49:569:4 94:2 110:16 111:20 269:

18 351:18

trimesters [2] 25:2,8

triple [12] 88:11,22 118:17

121:17 122:8 123:7,15 124:2

138:21 140:1 209:13 268:10

triples [1] 110:19

tripling [1] 111:9

trophic [1] 17:19

troubling [1] 250:11

true [9] 21:17 38:3 55:21,22

202:2 221:10 227:21 282:8

323:2

truly [4] 288:3 302:6 305:1

364:21try [40] 43:11 45:3,16 47:6,13,

16 48:9 50:2 55:5,18 56:8 57:

3,13 58:2 59:2,18 72:16 97:

21 149:12 165:5 176:11 179:

6 209:21 215:21 255:20 270:

22 271:2 283:11 284:2 287:3,

15 297:6 307:9 309:21 320:

10 328:17 337:20 339:13

343:8 347:7

trying [20] 44:8 58:8,17 67:21

68:6 102:14 104:12 112:4

162:8,12 165:3,22 179:4 216:

1 270:18 289:15 293:12 341:

7,19 354:15tsunami [1] 226:16tub [1] 303:16

tube [2] 236:7 252:9

tune [1] 104:12

TUNEL [6] 77:22 124:15 156:

1 160:9,9,22

turn [13] 76:19 79:20 246:10

252:1 254:10 265:8 266:19

317:9,11 333:9 334:9 341:2

342:22

turning [2] 254:3,11

turns [3] 107:16 272:9 300:1

Twelve [1] 81:18

twice [5] 127:10 138:13 211:

13,16 212:12Twin [2] 316:12,15

twins [2] 316:13,18

two [47] 23:1 25:18 30:4 49:

10 56:7 68:15,17 70:1,2,8 72:

18 76:17 96:16 100:22 106:9

111:2,21 115:22 116:4 117:

20 126:3 127:8 128:22 130:

15 155:7 157:22 204:6,7 220:

10 237:21,22 238:3 244:13

245:1 251:11 269:6 270:7

278:2 279:17 301:9 332:7

337:12,19 339:7,9 347:2 364:

therapy - two



11

type [24] 18:4,7 36:12,22 37:

10 38:1 68:21 80:17 107:17

120:2 152:7 174:8 233:4,18,

21 240:14 269:21 279:12

290:7 294:10 297:11 335:10

345:1,6

types [8] 14:22 59:19 78:2

148:20 158:1 196:20 241:11

330:19

typical[4]

114:22 123:14 124:12 189:13

Typically [5] 33:2 39:4 188:8,

14 206:5

UU.C [1] 228:22

U.S [4] 28:22 30:10 220:7 344:

1

UK [1] 344:1

ultimately [11] 44:18 47:1,11,

21 58:7,16 68:1,4 129:17

131:15 297:17

un-studyable [1] 363:15

unable [5] 47:21 145:6 276:2

317:9,11unavoidable [1] 28:14

uncle [1] 220:19

unclear [2] 51:9 242:22

uncomfortable [2] 303:15

325:9

uncontrolled [1] 193:13

uncover [1] 290:21

uncovered [1] 195:20

under [22] 18:7 23:19 32:9,14

81:19 90:11 94:7 100:7 142:

17 144:3 191:10 203:19 247:

7 291:19 292:3,17 293:8 294:

10 304:3 319:11 340:9 349:

19

underestimates [1] 38:6

undergo [3] 269:3,7 364:21

undergoing [11] 15:16 43:13

77:15 87:10 184:22 192:15,

16 194:9 196:12 208:9 346:4

undergone [5] 145:9 196:14

197:12 316:19 317:7

understand [42] 13:22 14:19

15:17 44:8 45:4,17 47:16 55:

18 56:3 58:8,17 59:3,19 68:6

69:7,9 103:8 149:12 151:8

165:22 176:13 179:4 181:4

191:10 204:7 205:17 206:17

207:1 211:1 218:12 288:12

293:7,9,12 294:11 308:18313:8 318:9 319:10 342:6

357:12 362:5

understanding [10] 13:12 44:

10 46:19 47:7 53:2 58:5 68:

20 72:13 267:2 329:6

understood [1] 364:15

underway [1] 57:12

underwent [2] 144:11 317:4

undesirable [2] 229:17,19

unfortunately [4] 61:8 97:5

209:16 307:5

Unified [1] 240:5

uniform [3] 100:9 347:14 362:

22

uniformly [1] 351:9

unique [3] 18:4 34:2 240:14

unit [3] 197:4 203:19 291:15

United [4] 27:19 235:4 325:

16 351:15

units [3] 135:17 212:21 213:3

University [17] 4:7,16 6:6,9,

11,15 7:3,7,9 8:8,12 228:5

247:18 248:7 257:3 275:3

303:12unknown [2] 40:6 202:4

unless [1] 336:19

unlike [2] 18:13 19:19

unlikely [4] 146:2 246:3 327:

1 338:20

unnoticed [1] 44:17

unrecognized [1] 109:20

unrelieved [3] 316:5 317:8,

21

unstimulated [1] 194:7

unsuccessful [1] 74:21until [11] 22:10 76:12 98:10152:16 201:5,8 212:7 222:17

275:22 287:10 299:20

untoward [1] 21:2unusual [1] 147:7unwanted [1] 140:22

up [88] 34:9 54:16 74:16 87:

11,15 114:8 118:7 119:4 121:

5,18 122:21 125:17 135:10

141:4 142:1 143:14 144:18

152:9 154:6,9,20 155:12,14

157:5 163:4,7,19 168:4 170:

5,8,11,15 172:19 174:15 181:

12 191:5 202:15 203:15 204:

15 205:6,20 208:3,18 211:20

215:13,13 225:2 231:10 236:

2 250:20 252:4,7 263:8,9

269:13 274:22 275:12,20276:10,16,22 277:19,20 284:

17 286:20 289:1 298:15 300:

12 308:4 315:2,3 316:8 319:

5 321:1,10 323:8,17 324:7

325:20 328:2 332:2 335:3

336:4 347:9 353:2,16 357:16

362:18

upheld [1] 30:10

upregated [1] 314:8

upregulated [2] 299:20 314:

6

upregulating [1] 360:10

upregulation [12] 154:17

155:1,18 161:4,5,21 162:4

175:2,5 176:18 178:1,5upregulator [1] 177:3

urge [1] 261:11

urgent [2] 36:11 307:18urinary [1] 21:7

usage [1] 265:18

useful [12] 14:18 15:1 289:15293:11,20 337:7,16 338:12

350:19 357:13,14 362:1

user [1] 228:21

users [1] 226:17

using [68] 19:9 34:16 61:11

70:7 75:17 77:20 79:10 80:5,

12 85:4 86:22 88:11 91:12

100:3 116:16 121:17 133:19

137:8 140:1 152:6 153:17

154:3,4 155:16 156:11,19,21

157:19,21 159:7 164:20 166:

1 167:2 173:1 180:4,16 186:

8 205:15 207:17 213:11 239:

16 250:17 251:15 252:18

254:19 255:1,20 264:17 281:

3 283:14 289:12 290:12 291:

2,5 295:18 296:17 304:17319:19,21,22 320:4,18,20

322:19 342:19 344:4 348:10

354:16

utero [5] 20:6 63:4 296:16

351:14 363:8

uterus [1] 353:21

utilize [1] 68:7

utilized [10] 35:2,10 42:8 53:

8,13 54:10,13 57:8 59:9 67:

15

utilizes [1] 240:15

utilizing [2] 42:17 43:10

V

vacuolization [1] 50:15valid [3] 90:1,16 91:15

validated [1] 290:11

validative [1] 291:9

valproic [1] 194:22

value [1] 73:8

values [8] 92:7 136:20 159:8

168:14 170:2,5,18 216:18

Van [4] 4:5 224:18,19,19

Vanderbilt [1] 7:6

vapor [11] 251:15 253:7,10

254:3,7,11,19 255:13,20 284:

20 352:3

vaporizers [3] 213:2 251:10

252:1

vapors [1] 252:6

variability [1] 351:11

variable [1] 292:9

variables [7] 196:21 199:11

287:4 288:1 292:18 344:3,13

variation [4] 114:10 190:22

294:6,7

variations [2] 105:21 122:3

varied [1] 166:20

varies [1] 190:7

variety [9] 182:9 205:12,12

262:19 281:6,7 290:11 351:7

357:1

various [16] 47:8 56:2 64:17

152:4 153:22 191:20 199:4,21 201:10 205:10 207:4 241:

11 254:1,15 341:16 349:1

vast [2] 229:12,13vehicle [1] 61:14

ventilate [1] 134:15

ventilated [1] 189:12

ventilation [3] 272:5 273:13,

18

ventilators [1] 190:1

ventilatory [1] 185:7

ventral [1] 278:10ventricle [1] 120:15

verify [1] 256:4

versa [1] 122:18

versus [24] 21:5 133:18 156:

18 171:19 174:16 186:2 200:

22 223:15 227:12,22 262:3

273:3,12 282:2,20 283:6 296:

13 309:22 321:12 323:6 341:

10 343:15 347:6 360:14

Vesna [23] 2:19 3:19 6:14 74:

14 84:20 88:20 90:3 150:2

155:5 162:11,16 167:9 172:2

173:21 179:19 180:4 181:1232:7 262:16 263:21 266:3

292:6 356:22

Vesna's [3] 88:11 181:20,22

vessicoamniotic [1] 21:7

veteran [1] 247:11

via [4] 18:2 240:13 241:8 242:

18

viability [1] 236:9

viable [3] 35:13 108:15,20

vice [1] 122:18

vicious [4] 236:18 238:10,20

239:9

view [7] 60:6 81:12 204:7 294:

1 316:6 333:14 365:4

Virginia [5] 4:6 6:15,16 8:3225:12

virtual [1] 226:16virtually [3] 19:13 152:6 334:

14

vis-a-vis [1] 112:7

visible [1] 126:14

visual [3] 276:8,13 349:9vital [4] 121:2 134:19 137:9224:3

vitality [1] 242:1

vitro [9] 19:3 153:16 156:19

175:4 177:16 205:4,5 239:10

288:5

vivo[15]

41:15 52:8 65:14158:8 159:10 166:7 175:3

176:13 177:16 204:12 205:6

239:12 262:21 263:13 288:4

volatile [4] 244:22 245:19

246:15,16

volume [1] 295:19

volumetric [2] 274:13 275:6

voluntary [2] 37:1 38:2

vomiting [1] 251:22

vote [5] 310:13,20 311:2,10

332:17

votes [1] 310:20

Voting [8] 2:5,16 6:22 7:1

311:4,8 315:9,13

vulnerability [14] 48:10,1749:2,16 75:21 122:9 123:4

192:18 313:7 314:11 341:9

344:15 357:18,19

vulnerable [11] 17:10 20:9

22:11 39:21 130:16 132:1

140:8 145:21 260:13 331:12

362:11

Wwait [4] 20:21 160:20 277:9305:11

waiting [1] 180:10

Wake [3] 6:11 252:4,7

two - Wake



wake-up [1] 251:12

walk [3] 133:6 226:12 297:7

walks [2] 37:2 358:18

Walnut [1] 249:16

wander [1] 137:3

Wang [2] 157:2 182:6

wanted [19] 74:18 118:6 119:

11 136:6 139:19 148:15 151:

7 156:13 158:8 164:5,18,22

165:9 188:6 209:13 270:21

271:7 337:13 357:16warm [1] 284:12

warrant [1] 265:17

Washington [2] 8:4 303:12

washout [5] 157:20 159:20

160:4 171:12,13

water [14] 84:9,10 102:1 126:

3,8,9,12 127:5 198:8 203:2

232:7 258:10,12 357:15

way [51] 38:7 85:6 98:17 102:

13 112:4 113:16 114:10 116:

13 120:13,14 128:12 133:10,

11 139:22 141:17 146:14

159:2 165:6 167:2 169:8,9

176:12 187:13 198:9 207:2

220:5 232:19,19 243:21 265:21 285:21 286:22 290:1 299:

8 302:16 304:22 321:10 325:

22 328:13 332:16 335:4 339:

17 341:7 344:6,17 347:22

358:16 359:21 360:2 361:5,6

Wayne [2] 2:23 8:10

ways [13] 67:21 153:14 155:

21 156:8 180:11 181:3,5 250:

18 287:15 299:21 327:2 339:

13 351:9

weakness [1] 263:20

Wechsler [2] 345:21 348:11

week [3] 17:5 112:17 220:11

weeks[16]

48:18 76:5 92:21108:18,20 112:12 133:16

189:22 262:12 269:8 271:14,

22 272:11 332:1,7 353:15

Wei [5] 4:16 256:8,9 269:13296:15

weighs [1] 167:12

weight [3] 101:22 110:17 359:

7

weighted [1] 39:3

weights [1] 285:9

weird [1] 252:4

Welcome [4] 11:1 16:10 41:9

243:6

well-controlled [4] 24:20 25:

21 26:5 29:9well-designed [2] 13:1 146:

18

well-known [1] 117:6

well-understood [1] 364:13

western [2] 28:20 79:11

whatever [4] 134:13 225:19

265:18 283:22

whatsoever [2] 57:17 297:21

whereas [7] 50:5 63:2 92:20

whether [40] 30:20 51:9 52:8

76:9 106:17 109:6 125:8 146:

15 163:13 164:22 199:22

200:1 205:7 209:14,18 215:3,

14 231:21,21 261:20 266:3,

11 273:11 277:7 291:20 292:

22 297:1 309:13 310:9 312:

16 314:9 315:11 321:14 327:

21 343:8 352:6,8,10 360:7,8

white [8] 19:1 23:14,20 272:

20 273:6,22 274:14,17white-matter [1] 274:13

whole [22] 39:19 110:10 119:

14 125:15,22 138:20 145:2

183:11 189:4 193:7,20 194:1

222:21 226:3,21 230:19 285:

8 296:6 297:9 331:21 339:1

346:5

whom [4] 28:7 261:15,19 264:

16

wide [2] 183:8 243:1

widely [2] 222:12 254:20

widespread [6] 43:18 50:20

55:11 85:13 118:21 299:1

widest [1] 97:14

wife [2] 220:8 221:21wild [3] 233:4,18,21

wild-type [2] 232:15 233:6

will [159] 5:13,16 6:20 10:9,15,17,19 13:5,15,21,22 14:5,11,

14,22 16:3,16 22:12 34:8 36:

6,7 40:12,16 41:5 42:1 43:1

48:3,4,5 50:11 51:3,7 52:14

54:7 58:6 61:8 63:13 67:6,8,

9,18,19 69:11 71:5,5 74:2,3,

11,14 78:1 82:16 83:7 84:6,

20 85:9,16 89:17 93:10 97:

21 99:15,17,18 103:1,2,4,7

107:21 109:7 112:6 113:5,18

119:6,17 120:17 135:3 140:20 146:13 147:1,8,9,12,13

156:8 165:21 166:4 167:18,

19 168:1,3 169:16 180:7,10

181:5 182:18,20 183:1 195:

17 196:12 197:9 201:6 206:

22 214:8,9 216:22 219:8,10,

17,20,21 221:17 222:2 223:

19 233:16 234:17 235:5,8

237:14 238:15,19 243:16

245:6 250:2 254:6,16 257:4

259:21,22 260:3,6,10 266:19

269:7 273:5 275:12 276:1

278:21 282:7 287:2 291:7,10

298:3,4 301:19 311:10,17

314:20 315:17 319:22 320:19 326:7 327:17 330:12 333:

3,16 334:9 338:15 339:15

344:6 345:11

William [4] 2:31 3:23 48:3

147:13

willing [1] 303:5

willingness [1] 15:21

wind [1] 276:16

window [9] 48:10 16 75:20

wine [1] 103:21

wish [3] 10:13 170:22 277:13

wishing [1] 334:8

wit [1] 29:2

withdrawal [6] 66:4 152:6,9153:8 159:16 166:16

withdrew [1] 159:17

withhold [1] 147:2

within [20] 23:22 43:18 46:12

48:17 66:14 89:12 92:17 136:

21 149:14 153:15 162:6 167:14,15 199:8 326:10,15,17

332:7 339:8,9

without [16] 115:17 125:8

161:5 169:14 193:8 221:13

237:10 251:14 252:15 253:5

254:6 257:10 277:9 287:7

325:6 345:2

Wlody [8] 2:11 7:8,8 69:17

312:5 313:17 320:22 335:2

woman [1] 27:1

women [12] 24:20 25:6,22 26:

12 31:4 278:17 350:5,14 352:

16,20 353:13 363:6

Women's [1] 4:19

wonder [5] 69:22 70:4,6 315:14 352:6

wondered [1] 103:19

wonderful [3] 101:6 224:15326:3

wondering [2] 214:14 291:18

words [1] 309:20

work [44] 35:12 48:15 115:20

119:14 120:21 134:1,9 145:

15 147:22 149:8,8,18 150:12

155:5 157:1,16 162:13 170:1

171:5 173:20 175:4 181:14,

20 182:5 185:22 193:12 202:

10 209:4 210:17,18 229:10,

13 231:19 232:2 253:20 270:20 271:6 281:7 287:13,20

293:16 298:10 314:18 326:3

worked [1] 363:4

Working [11] 44:19 84:22

104:12 149:19 161:9 162:7

182:7,11 288:9 309:8 361:15

workload-reducing [1] 255:

7

works [2] 298:9,9

world [6] 57:5 86:9 235:4 286:

6 326:15,17

worldwide [1] 235:18

wormlike [1] 79:1

worrisome [2] 244:9 313:3

worry [1] 253:13worse [2] 127:16 138:20

worst [3] 60:6 73:1 286:22

worth [3] 20:2 23:1 54:10

worthwhile [1] 293:1

worthy [1] 333:1

Wozniak [3] 125:14 209:5

210:17

WPSSI [1] 346:1Wright [1] 227:16

xenon [12] 117:11 294:14,15,

19,21 295:1,4 296:6 297:1

319:1 320:9 328:22

Xie [3] 4:9 234:17,18

YYale [2] 8:1 275:3

yank [1] 252:9

year [12] 29:3 30:3 33:10 38:

15 110:18 235:9,19 241:17

249:20 314:4 316:15 351:17

years [76] 17:7 21:20 22:22

23:19 28:1,2,15 30:4 32:20

34:5,9 38:18 39:3 49:7,21 52:

12 68:11 69:5 75:1 76:7 83:

16,17 85:7 105:2 108:5,9,15

111:21 142:1,9 143:14 144:

20 148:1 161:10 162:14 163:

7 165:15 167:7 182:8 184:1

197:22,22 200:2,2,2,3 201:3

212:7 220:13 225:11,13,22

227:4 234:5 246:2 247:2,5

264:6 275:5,9 276:11,17,19

277:1,10 291:1 296:17 301:2,

3 303:2 308:16 316:17 323:5

345:21 358:15 359:16yellow [1] 219:12

York [1] 7:10

young [17] 35:15 109:3 110:3

124:22 125:1 146:20 153:20

164:15 221:17 226:8 228:19

244:15 263:9,12,14,15 277:3

younger [4] 141:22 143:13

144:19 264:12

yourself [1] 306:20

yourselves [1] 5:7

ZZARS [2] 8:21 10:2

Zee [4] 4:5 224:18,19,19

Zelterman [6] 2:24 7:22,22312:2 313:14 362:7

zero [8] 91:19 120:5 127:4

130:2,19 152:1,17 153:5

zeroed [2] 140:8 211:4

Zhong [1] 4:9

zone [1] 102:6

Zorumski [1] 268:7Zuppa [26] 2:25 7:18,19 99:

22 100:1,16 214:10 215:10

268:8 270:7 271:5 273:15

288:22 291:13 293:22 307:5

312:3 313:15 319:13 323:10

329:15 331:7 335:7 342:9

346:18347:

12

wake-up - Zuppa

us food and drug administration: 2007-4285t1-index

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