use and care of vertebrate animals: what researchers need to know brian greene iacuc chair and...
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Use and Care of Vertebrate Animals: What Researchers Need to Know
Brian GreeneIACUC Chair and Associate Professor of BiologyMissouri State University
Legislation and GuidanceAnimal Welfare Act
(1966) and Health Research Extension Act (1985) stipulate animal welfare regulations◦ Humane care◦ Minimization of pain and
distressEmphasizes minimal
use of animals and appropriate justification◦ The 3 r’s
IACUC Structure and Function
Mandated membershipReview all research proposals
and monitor their activities Semi-annual facilities inspections
and program reviewAnnual report to OLAWSuspension of research activities
if violations occur
Importance of IACUC oversight for researchers
Institutional compliance – significant penalties for violations
Training – improves study designResearch quality – healthy
animals yield better dataProfessional obligation – IACUC
approval is often a prerequisite for publication and funding
What do I need to do? Complete online animal care
training◦OSRP web page access IACUC link
Occupational Health and Safety Screening◦Risk assessment form – filled out by
supervisor◦Health history form – evaluated at
Taylor HealthAnimal Care Protocol for each
new study◦Submitted to IACUC email address
Animal Care and Use Training
Animal and Care Use Compliance Training
Animal Care and Use
This course utilizes materials from standard laboratory animal textbooks, the Animal Welfare Act regulations, the Public Health Service (PHS) Policy, the Guide for the Care and Use of Laboratory Animals, Occupational Health and Safety in the Care and Use of Research Animals, the Use of Experimental Animals at Missouri State University and the Office of Laboratory Animal Welfare, McGill University, National Institutes of Health. The modules provide information that all individuals who use animals in research, testing, and teaching should know.
Questions regarding the course or requirements for certification should be directed to: Ms. Tracey Poston, Associate Director & Compliance Officer, Office of Sponsored Research and ProgramsPhone: (417) 836-5972Email:[email protected]
Resource Page
Page 3 of 8
Sponsored Research and Programs, Missouri State University | © 2006 | Disclaimer | EO/AA | Accessibility | Maintained by: Office of Sponsored Research and Programs | Last Modified: October 28, 2008| Phone: (417) 836-5972 | Fax: (417)
836-8818 | URL: http://apps.missouristate.edu/srp/AnimalTraining/index.asp
Missouri State University
Progress:
The research protocol: basic components• Species and approximate numbers used• Rationale for animal use, appropriateness
of species, and benefits of research• Complete description of animal use and
care• Descriptions of how injury and discomfort
will be minimized to that which is unavoidable to conduct research and managed by anesthetics or analgesics
• Description of any euthanasia methods used
MSU Protocol Cover Page
Project TitleContact Information
◦ Principal investigatorProject
Characterization◦ Status (new, renewal,
amendment to existing protocol)
◦ Type◦ Research category
Protocol : Section 1
Personnel Information◦ Identify everyone
involved with project◦ Describe all relevant
training List online modules Lab–specific training Previous experience
◦ Project description Goals & objectives Design summary Justification Literature search
Protocol Section 2: Project Description
Non-technical summary – explain goals, objectives, benefits of study, design and methods
Justification◦Species used and numbers required◦Use as many relevant arguments as
possible
Protocol Section 2.3Required Keyword Search
Evaluate literature for appropriate and/or alternative methods
Important criteria◦ Duplication of effort◦ Use of animal model
Must be current (< 2 months old)Required information:
◦ Date of search◦ Keywords used◦ Search resources◦ Years covered by search results
Written summary of results
Section 3: Animal Use
Animal Sources, species, and numbers used◦ Approved sources◦ Wild animals collected with
permission Animal facilities:
◦ Locations for all activities Animal husbandry
summary◦ Housing, food, environmental
or lab conditions, etc. Animal procedures
◦ Check appropriate boxes◦ Some require additional forms
(surgery, field studies, etc.)
Animal Use – Pain and Distress
Pain and distress categories◦ Indicate number of each animal used in
each pain category◦ Category 5 pain must be carefully justified
Pain alleviation◦ Drug type and administration
Investigator AssurancesSigned list of
statements that confirms adherence to rules
Declaration that everything is correct and that you will follow the protocol as approved
Signature for PI and Co-PI (graduate student)
Submit to: [email protected]
Additional ResourcesIACUC web page
◦MSU Animal Care Policies and SOP◦External web resources◦Downloadable forms◦Links to online training
Outside resources◦IACUC guidelines of professional
societies◦ILAR journal