Used for 5,000 years by both Chinese and Indian systems of medicine, Curcumin and Piperin are now formulated to tremendously amplify their

healing abilities.

Curcumin has been used in the Chinese and Indian systems of medicine as an anti-inflammatory agent to treat a wide variety of conditions, including flatulence, jaundice, menstrual difficulties, bloody urine, hemorrhage, toothache, bruises, chest pain, colic, and many other illnesses.

HISTORICAL BENEFIT

PiCur® is a result of extensive research and development by father and son scientists Richard and Rigel Gomez.

PiCur® is included in the Philippine Inventors Catalog and Directory, an academic reference book published by the Filipino Inventors’ Society and has been featured on several publications and shows.

DEVELOPMENT OF PiCur®

DEVELOPMENT OF PiCur®

Richard and Rigel are members of Mensa, a worldwide organization of people with very high IQ. They have strong inclination to math and sciences and have excelled in those fields. Richard Gomez is a member of the Filipino Inventors’ Society while Rigel has won several National Level competitions.

Richard and Rigel received the prestigious Dangal ng Bayan Award for Outstanding Contribution in the Field of Science. Rigel has received commendations from the Department of Education and from the Local Government of Pasig City.

DEVELOPMENT OF PiCur®

Richard and Rigel are members of Mensa, a worldwide organization of people with very high IQ. They have strong inclination to math and sciences and have excelled in those fields. Richard Gomez is a member of the Filipino Inventors’ Society while Rigel has won several National Level competitions.

Richard and Rigel received the prestigious Dangal ng Bayan Award for Outstanding Contribution in the Field of Science. Rigel has received commendations from the Department of Education and from the Local Government of Pasig City.

THE PiCur® TECHNOLOGY

Extraction of the rhizome Curcumin and alkaloid Piperine is done in a laboratory outside the Philippines.

Blending of PiCur® is done in the Philippines

Finished capsules are tested in another laboratory outside the Philippines.

1,000 Grams of fresh Turmeric

100 Grams of dried / powdered Turmeric= 10% Utilization

5 Grams of the rhizome Curcumin= 5% Utilization=0.5% Over-all Utilization

THE PiCur® TECHNOLOGY

1,000 Grams of fresh Piper longum

100 Grams of dried / powdered Piper longum= 10 Utilized

1 Gram of the alkaloid Piperine= 1% Utilized= 0.1% Over-all Utilization

THE PiCur® TECHNOLOGY

The result is life changing supplement now known as

PiCur®

THE PiCur® TECHNOLOGY

PiCur™ is a patented blend. The GlobaLeader Inc. has exclusive access to the incredible powers of PiCur™ and all of its derivatives and variants.

Impossible to copy

Patent, Trademark, and Copyright in 126 territories and

jurisdictions are in process.

Over 3,000 actual clinical and laboratory studies conducted by thousands of doctors and scientists throughout the world

Researches supported by the US National Library of Medicine and the National institutes of Health

SUPPORTING SCIENTIFIC RESEARCHES

•Nagabhushan M, Bhide SV. Curcumin as an inhibitor of cancer. J Am Coll Nutr. 1992 Apr;11(2):192-8. 1992. PMID:1578097.

Cancer Prevention

Curcumin's extremely high antioxidant action enables it to protect the colon cells from free radicals that can damage cellular DNA—a significant benefit particularly in the colon. It include inhibiting the synthesis of a protein thought to be instrumental in tumor formation and preventing the development of additional blood supply necessary for cancer cell growth.

Inhibits Cancer Cell Growth and Metastases

Epidemiological studies have linked the frequent use of curcumin to lower rates of breast, prostate, lung and colon cancer; laboratory experiments have shown curcumin can prevent tumors from forming; and research conducted at the University of Texas suggests that even when breast cancer is already present, curcumin can help slow the spread of breast cancer cells to the lungs in mice.

In addition, curcumin was found to suppress cancer cell proliferation and to induce cell cycle arrest and apoptosis (cell suicide) in the lung cancer cells. Early phase I clinical trials at the University of Texas are now also looking into curcumin's chemopreventive and therapeutic properties against multiple myeloma and pancreatic cancer, and other research groups are investigating curcumin's ability to prevent oral cancer.

•Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, Jacobson K. Curcumin attenuates DNB-induced murine colitis. Am J Physiol Gastrointest Liver Physiol. Jul;285(1):G235-43. Epub 2003 Mar 13 2003. PMID:12637253.• Johnson JJ, Mukhtar H. University of Wisconsin, School of Pharmacy, 777 Highland Avenue, Madison, WI 53705-2222, USA. jjjohnson6@wisc.edu

Curcumin and Onions May Help Prevent Colon Cancer

Curcumin, a phytonutrient, and quercitin, an antioxidant in onions, reduce both the size and number of precancerous lesions in the human intestinal tract, as shown on a research published in the August 2006 issue of Clinical Gasteroenterology and Hepatology.

•Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, Jacobson K. Curcumin attenuates DNB-induced murine colitis. Am J Physiol Gastrointest Liver Physiol. Jul;285(1):G235-43. Epub 2003 Mar 13 2003. PMID:12637253.• Johnson JJ, Mukhtar H. University of Wisconsin, School of Pharmacy, 777 Highland Avenue, Madison, WI 53705-2222, USA. jjjohnson6@wisc.edu

Curcumin Teams Up with Cauliflower to Halt Prostate Cancer Prostate cancer—the second leading cause of cancer death in American men with 500,000 new cases appearing each year—is a rare occurrence among men in India, whose low risk is attributed to a diet rich in brassica family vegetables and curcumin.

•Nakamura K, Yasunaga Y, Segawa T et al. Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int J Oncol 2002 Oct;21(4):825-30 2002•Dorai T, Cao YC, Dorai B, et al. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 2001 Jun 1;47(4):293-303 2001. PMID:16280.• Khor TO, Keum YS, Lin W, Kim JH, Hu1 R, Shen G, Xu1 C, Gopalakrishnan A, Reddy B, Zheng X, Conney AH, Kong AN. Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice. Cancer Research. 2006 Jan; 66(2): 613-621. 2006. PMID:16423986.

•Nakamura K, Yasunaga Y, Segawa T et al. Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int J Oncol 2002 Oct;21(4):825-30 2002•Dorai T, Cao YC, Dorai B, et al. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 2001 Jun 1;47(4):293-303 2001. PMID:16280.• Khor TO, Keum YS, Lin W, Kim JH, Hu1 R, Shen G, Xu1 C, Gopalakrishnan A, Reddy B, Zheng X, Conney AH, Kong AN. Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice. Cancer Research. 2006 Jan; 66(2): 613-621. 2006. PMID:16423986.

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Curcumin helps fight breast cancer

In a study published in Biochemical Pharmacology (September 2005), human breast cancer cells were injected into mice, and the resulting tumors removed to simulate a mastectomy.

•Aggarwal B. Paper presented at the U.S. Defense Department's 'Era of Hope' Breast Cancer Research Program meeting in Philadelphia, PA, October 5, 2005,. reported in NUTRAingredients.com/Europe "Turmeric slows breast cancer spread in mice.".

After five weeks:Control group = 5% curedTaxol only group = 25% curedCurcumin only group = 50% curedCurcumin + Taxol group = 78% cured

The mice were then divided into four groups. One group received no further treatment and served as a control. A second group was given the cancer drug paclitaxel (Taxol); the third got curcumin, and the fourth was given both Taxol and curcumin.

•Nagabhushan M. Research presented at the Children with Leukaemia Conference, www.leukaemia.org, September 2004 2004.

Reduces Risk of Childhood Leukemia

Research presented at a recent conference on childhood leukemia, held in London, provides evidence that curcumin intake reduce the risk of developing childhood leukemia.

•Nagabhushan M. Research presented at the Children with Leukaemia Conference, www.leukaemia.org, September 2004 2004.

Reduces Risk of Childhood Leukemia

Research presented at a recent conference on childhood leukemia, held in London, provides evidence that curcumin intake reduce the risk of developing childhood leukemia.

Some medical conditions where PiCur® may help:

Very Potent Yet Safe Anti-Inflammatory Effective Treatment for Inflammatory Bowel Disease Relief for Rheumatoid Arthritis Help for Cystic Fibrosis Sufferers Cancer Prevention Inhibits Cancer Cell Growth and Metastases Teams up with Onions May Help Prevent Colon Cancer Curcumin helps fight breast cancer Teams Up with Cauliflower to Halt Prostate Cancer Reduce Risk of Childhood Leukemia Improved Liver Function Cardiovascular Protection Protection against Alzheimer's Disease Protection against diseases Natural Weight Loss Formula