usf – bioinformatics master project outline buck institute the mooney lab project description 1
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USF – Bioinformatics Master Project
Outline
• Buck Institute
• The Mooney Lab
• Project Description
Buck Institute for Research on Aging
History1975
19861987
1989
1996
• 1987 – the Marin Superior Court selected the Institute to receive 15% of the net income from Beryl Buck’s estate• 1989 – the Buck purchased a 488-acre parcel of undeveloped land on Mt. Burdell in Novato
• 1996 – construction began
• 1986 – The “Buck Institute on Aging” was incorporated.
• The San Francisco Foundation established.
(at the time estimated at $11 - $12 million)
1999
2010
• 2010 – the value of the Buck Trust had grown to over $700 million, generating an annual income for the Institute of approximately $6 million per year.
• 1999 – The buck opened
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Buck Institute for Research on Aging
The Future for the Buck
New construction for stem-cell lab building - $41 million project
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Buck Institute for Research on Aging
The Buck Today
• Mission – To increase the healthy years of life by investigating how
normal aging contributes to the development of diseases.
• Employees – 200
• Faculty – 18 labs
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Buck Institute for Research on Aging
o Parkinson disease
o Alzheimer
o cancer
o stroke
o nutrition
o stress
o genetics
o stem cells
o bioinformatics
Main research focus:
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The Mooney Lab
Responsibilities
• Core – support other labs in the institute to:
o handle, store, and retrieve data
o analyze biological data
o use tools to generate biological hypotheses
• Independent research –
o identify and classify diseases causing mutations
o analyze protein structure to estimate structure similarities,
predict catalytic and protein-protein interaction sites.
o using ontologies to classify gene function
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Lab’s Web Tools
Plugin - a container for a group of related resources (software components), embedded in a larger software application to extend its functionality.
ChimeraPymol
LSWPlugin
LSWPlugin
Life Science Web Services Plug-ins
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Integration
p53
Canc
er M
utati
ons
Lab’s Web Tools:• S-Blest
• CRP
• MutDB
• PPI
Chimera, Pymol:• Analyze molecular structure
• Provide: images, animations,
interactive Visualization
setuptoolsSOAP
API
Easy InstallEgg files
Packages
LSW Services:
MD5
distutils
Life Science Web Services Plug-ins
services
WSDL
