using routine immunization to eliminate measles & rubella ......what is routine immunization? 5...
TRANSCRIPT
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Using Routine Immunization
to Eliminate Measles & Rubella:
Time for a change?
September 10, 2014
Samir Sodha, MD, MPHGlobal Immunization Division
Centers for Disease Control and Prevention
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What is Routine
Immunization?
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What is Routine Immunization?
3
Wiki Answers website• No standard definition
— Hard to define— Means different things to different people
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What is Routine Immunization?
4
• Coverage Improvement?— Global targets
• 90% national MCV1 coverage in all countries• 80% MCV1 coverage in every district
— Coverage improvement = RI system strengthening?
Coverage Improvement
RI System Strengthening
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What is Routine Immunization?
5
Wiki Answers website• No standard definition
— Hard to define— Means different things to different people
• Sum of human and logistical activities/events to ensure theregular delivery & uptake of vaccines & the monitoring of their positive & adverse impact— Implies the "regular" delivery, i.e., known schedule, of
EPI vaccines• Fixed posts &/or outreach
— Part of a larger plan— Not time limited— Goal to provide needed vaccines to all eligible persons
and to successive birth cohorts
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© 2012 Bill & Melinda Gates Foundation | 6
GLOBAL NATIONAL LOCAL
POLITICAL COMMITMENT FINANCING & PRICING
Health worker
Sufficient
supplies at
health posts
Community
engagement &
demand creation
MotivationTraining &
mentorship
National
motivation
Inventory
managementSupply
planning
Storage and
distribution
Procurement
& distribution
Manufacturing
Global indicators
Data to guide
national decision
making
National training /
professional programs
and supervision
Supervisors
& FLWs
National &
sub-national
program
managers
Global guidelines
Collection &
use of data
POINT OF VACCINATION
ENABLING PARTNER
ENVIRONMENT
Governance, stability, and national infrastructure essential to vaccination systems but out of scope here.
GLOBAL NATIONAL LOCAL
POLITICAL COMMITMENT FINANCING & PRICING
Health worker
Sufficient
supplies at
health posts
Community
engagement &
demand creation
MotivationTraining &
mentorship
National
motivation
Inventory
managementSupply
planning
Storage and
distribution
Procurement
& distribution
Manufacturing
Global indicators
Data to guide
national decision
making
National training /
professional programs
and supervision
Supervisors
& FLWs
National &
sub-national
program
managers
Global guidelines
Collection &
use of data
POINT OF VACCINATION
ENABLING PARTNER
ENVIRONMENT
GLOBAL NATIONAL LOCAL
POLITICAL COMMITMENT FINANCING & PRICING
Health worker
Sufficient
supplies at
health posts
Community
engagement &
demand creation
MotivationTraining &
mentorship
National
motivation
Inventory
managementSupply
planning
Storage and
distribution
Procurement
& distribution
Manufacturing
Global indicators
Data to guide
national decision
making
National training /
professional programs
and supervision
Supervisors
& FLWs
National &
sub-national
program
managers
Global guidelines
Collection &
use of data
POINT OF VACCINATION
ENABLING PARTNER
ENVIRONMENT
GLOBAL NATIONAL LOCAL
POLITICAL COMMITMENT FINANCING & PRICING
Health worker
Sufficient
supplies at
health posts
Community
engagement &
demand creation
MotivationTraining &
mentorship
National
motivation
Inventory
managementSupply
planning
Storage and
distribution
Procurement
& distribution
Manufacturing
Global indicators
Data to guide
national decision
making
National training /
professional programs
and supervision
Supervisors
& FLWs
National &
sub-national
program
managers
Global guidelines
Collection &
use of data
POINT OF VACCINATION
ENABLING PARTNER
ENVIRONMENT
GLOBAL NATIONAL LOCAL
POLITICAL COMMITMENT FINANCING & PRICING
Health worker
Sufficient
supplies at
health posts
Community
engagement &
demand creation
MotivationTraining &
mentorship
National
motivation
Inventory
managementSupply
planning
Storage and
distribution
Procurement
& distribution
Manufacturing
Global indicators
Data to guide
national decision
making
National training /
professional programs
and supervision
Supervisors
& FLWs
National &
sub-national
program
managers
Global guidelines
Collection &
use of data
POINT OF VACCINATION
ENABLING PARTNER
ENVIRONMENT
GLOBAL NATIONAL LOCAL
POLITICAL COMMITMENT FINANCING & PRICING
Health worker
Sufficient
supplies at
health posts
Community
engagement &
demand creation
MotivationTraining &
mentorship
National
motivation
Inventory
managementSupply
planning
Storage and
distribution
Procurement
& distribution
Manufacturing
Global indicators
Data to guide
national decision
making
National training /
professional programs
and supervision
Supervisors
& FLWs
National &
sub-national
program
managers
Global guidelines
Collection &
use of data
POINT OF VACCINATION
ENABLING PARTNER
ENVIRONMENT
System components
POLITICAL COMMITMENTPolitical commitment FINANCING & PRICINGFinancing and pricing
Community
engagement
Human resources for health
ENABLING PARTNER
ENVIRONMENT
Enabling partner
environment
Supply chain
& logistics
Monitoring & use of
dataPerformance
management,
training,
leadership
GLOBAL NATIONAL LOCAL
POLITICAL COMMITMENT FINANCING & PRICING
Health worker
Sufficient
supplies at
health posts
Community
engagement &
demand creation
MotivationTraining &
mentorship
National
motivation
Inventory
managementSupply
planning
Storage and
distribution
Procurement
& distribution
Manufacturing
Global indicators
Data to guide
national decision
making
National training /
professional programs
and supervision
Supervisors
& FLWs
National &
sub-national
program
managers
Global guidelines
Collection &
use of data
POINT OF VACCINATION
ENABLING PARTNER
ENVIRONMENT
Courtesy of BMGF
What is the Routine Immunization System?
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Bring quality vaccine and
supplies to vaccination site
Bring trained vaccinators
to vaccination site
Informed caregiver brings
child to vaccination site
What is the Routine Immunization System?
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Bring quality vaccine and
supplies to vaccination site
What is the Routine Immunization System?
1. National procurement
2. Inventory management
3. Cold chain
4. Logistics / Distribution
5. Vaccine Forecasting
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Bring trained vaccinators
to vaccination site
What is the Routine Immunization System?
1. Human resources
2. Training / Mentorship / Capacity building
3. Supervision
4. Motivation
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Informed caregiver brings
child to vaccination site
What is the Routine Immunization System?
1. Community engagement
2. Social mobilization
3. Communications
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1. Political commitment 2. Enabling partner environment
3. Monitoring and use of data 4. Planning and Management
The Wheels of Routine Immunization
$
What is the Routine Immunization System?
RI
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The RI Road
(Coverage)
50% 80% 90%
What is the Routine Immunization System?
RI
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The RI Road
(Coverage)
50% 80% 90%
What is the Routine Immunization System?
RI
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The RI Road
(Coverage)
50% 80% 90%
RI coverage shouldn’t be a
destination or endpoint
What is the Routine Immunization System?
RI
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Routine Immunization Coverage
Speedometer
What is the Routine Immunization System?
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Routine Immunization Coverage
Speedometer
What is the Routine Immunization System?
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Routine Immunization Coverage
Speedometer
Goal is to ATTAIN and
SUSTAIN RI coverage
What is the Routine Immunization System?
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Synergy between Routine Immunization and Measles & Rubella Elimination
18
Measles/Rubella Elimination
SIAs
Outbreak response
Routine Immunization Strengthening
MRCV1
MRCV2
MRCV = measles- and rubella-containing vaccine
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Challenges to Increase MRCV Coverage
19
• Missed opportunities • Fear of wastage• Fear of stockout• False contraindications
• Weak platform for vaccination in 2nd year of life
Reluctance to open vial
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Missed Opportunities
20
Policies/Practices Consequences
Measles vaccine on specific days to increase session size (weekly or monthly)
Missed opportunities (turn away children on other days?)
Require minimum number of children to open vial
Missed opportunities (turn awaychildren of smaller sessions)
Limit vaccinations to <12 month olds
Missed opportunities (turn away older children)
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Missed Opportunities
21
Policies/Practices Consequences
Measles vaccine on specific days to increase session size (weekly or monthly)
Missed opportunities (turn away children on other days?)
Require minimum number of children to open vial
Missed opportunities (turn awaychildren of smaller sessions)
Limit vaccinations to <12 month olds
Missed opportunities (turn away older children)
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Opening Vial: Impact on Coverage
22Source: Stokes-Prindle C et al. Coverage, cost and safety implications of primary container choice. IVAC, 2013
Session size range
Coverage by session size if health worker opens 10 dose vials only for sessions where ≥50% of doses will be used (≥ 5 eligible children present)
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Practices Related to Wastage
Cambodia(95% MCV1 coverage)
Nigeria(57% MCV1 coverage)
Average measles vaccine wastage rate in health centers
58% 19%
Average number of children before opening measles vaccine vial
2.2 6.2
Proportion of parents saying they were turned away for vaccination
4% 30%
Source: unpublished data, 2011 Nigeria CDC/WHO/NPHCDA study, 2013 Cambodia WHO/CDC/MOH study in nationally representative samples of health facilities
How to reduce the threshold to open a vaccine vial?
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Wastage and Vial Size
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Missed Opportunities
25
Policies/Practices Consequences
Measles vaccine on specific days to increase session size (weekly or monthly)
Missed opportunities (turn away children on other days?)
Require minimum number of children to open vial
Missed opportunities (turn awaychildren of smaller sessions)
Limit vaccinations to <12 month olds
Missed opportunities (turn away older children)
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Challenges to Increase MRCV Coverage
26
• Missed opportunities • Fear of wastage• Fear of stockout• False contraindications
• Weak platform for vaccination in 2nd year of life
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Benefits to Stronger Platform in 2nd Year of Life1) Higher coverage of second dose of measles-containing
vaccine (MCV2) / DTP booster doses
2) Catch-up (higher coverage) of antigens offered in first year of life (e.g. DTP, MCV1)
3) Strong platform for newer vaccines (e.g. malaria)
4) Opportunities to integrate with other health interventions
Vaccination in 2nd Year of Life
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Age of administration
RegionNumber of countries No MCV2 ≤2 years 3-7 years >7 years
AFR 46 34 (74%) 9 (20%) 3 (7%) -
AMR 35 4 (11%) 8 (23%) 23 (66%) -
EMR 22 2 (9%) 17 (77%) 3 (14%) -
EUR 53 0 (0) 6 (11%) 37 (70%) 10 (19%)
SEAR 11 2 (18%) 6 (55%) 3 (27%) -
WPR 27 3 (11%) 13 (48%) 11 (41%) -
Total 194 45 (23%) 59 (30%) 80 (41%) 10 (5%)
MCV2 Schedules in 2012
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29
Benefits to Stronger Platform in 2nd Year of Life1) Higher coverage of booster doses /second dose of measles-
containing vaccine (MCV2)
2) Catch-up (higher coverage) of antigens offered in first year of life (e.g. DTP, MCV1)
3) Strong platform for newer vaccines (e.g. malaria)
4) Opportunities to integrate with other health interventions
Vaccination in 2nd Year of Life
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0
10
20
30
40
50
60
70
80
90
100
0 13 26 39 52 65 78 91
Northern
Central
Southern
Western
104
Perc
en
t V
accin
ate
d b
y e
nd
of
ag
e i
nte
rval
Age in weeks
80.1%
Presented at the Caribbean EPI Managers Meeting 2009
MMR1 Coverage by Age and Region, Belize, 2005 - 2008
91.0%
95.4%94.4%
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31
Benefits to Stronger Platform in 2nd Year of Life1) Higher coverage of booster doses /second dose of measles-
containing vaccine (MCV2)
2) Catch-up (higher coverage) of antigens offered in first year of life (e.g. DTP, MCV1)
3) Strong platform for newer vaccines (e.g. malaria)
4) Opportunities to integrate with other health interventions
Vaccination in 2nd Year of Life
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32
Benefits to Stronger Platform in 2nd Year of Life1) Higher coverage of booster doses /second dose of measles-
containing vaccine (MCV2)
2) Higher coverage of antigens offered in first year of life (e.g. DTP, MCV1)
3) Strong platform for newer vaccines (e.g. malaria)
4) Opportunities to integrate with other health interventions
Vaccination in 2nd Year of Life
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33
Challenges to Establishing Stronger Platform 1) Monitoring and accountability
• Should coverage for all vaccines be measured in 24-35 month olds in addition to 12-23 month olds?
2) Restrictive government policies
3) Poor recording/reporting for vaccinating in 2nd year of life
4) Need to improve vaccine forecasting (minimize stockouts)
5) Need to retrain and educate health workers
6) Need to increase awareness with communities
Vaccination in 2nd Year of Life
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Summary
34
• Strengthening routine immunization system is not equal to improving coverage
• Routine immunization system has multiple components working together to attain and sustain coverage
• To achieve measles and rubella elimination consider specific routine immunization issues affecting MRCV coverage• Reluctance to open vaccine vial• Platform for vaccination in 2nd year of life
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Thank you!
35
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Wastage and 2 Dose Schedule
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2012 Top 15 Unimmunized MCV121.2 million unimmunized globally
Rank Country Unimmunized
1 India 6,371,156
2 Nigeria 3,760,114
3 Ethiopia 995,893
4 Indonesia 922,723
5 Pakistan 731,167
6 DR Congo 682,752
7 Philippines 349,873
8 USA 335,952
9 Afghanistan 314,077
10 Iraq 312,193
11 Uganda 269,810
12 Mali 263,527
13 Madagascar 232,913
14 Somalia 224,540
15 South Africa 222,200
64%
Coverage
74
42
66
80
83
73
85
92
68
69
82
59
69
46
79
Based on WHO/UNICEF estimates