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Transcriptional control of cytotoxic lymphocytes An unexpected journey with HobitVieira Braga, F.A.

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Citation for published version (APA):Vieira Braga, F. A. (2017). Transcriptional control of cytotoxic lymphocytes: An unexpectedjourney with Hobit.

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Download date:03 Sep 2021

Transcriptionalcontrol of cytotoxic lymphocytes

An unexpected journey with Hobit

Transcriptional control of cytotoxic lymphocytes

An unexpected journey with H

obit

felipe a. vieira braga .

Transcriptional control of cytotoxic lymphocytes: an unexpected journey with Hobit

Felipe Augusto Vieira Braga

Printing was supported by: Sanquin Blood Supply Foundation, Amsterdam NL

©Felipe A Vieira Braga, 2017

ISBN: 978-94-92683-53-3Cover: Optima Grafische Communicatie Cover figure: creative commons licenseLay-out: Felipe A Vieira Braga. Printed by: Optima Grafische Communicatie

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor

aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie,

in het openbaar te verdedigen in de Agnietenkapel

op donderdag 08 Juni 2017, te 12:00 uur

door

Felipe Augusto Vieira Braga

geboren te Teresina, Brazilië

Transcriptional control of cytotoxic lymphocytes: an unexpected journey with Hobit

Promotiecommissie:

Promotor: Prof. dr. R.A.W. van Lier AMC-UvA

Copromotor: Dr. K.P.J.M van Gisbergen AMC-UvA

Overige leden: Dr. D. Amsen Sanquin Research Prof. dr. J. Borst AMC-UvA Prof. dr. E.F. Eldering AMC-UvA Prof. dr. A. Oxenius ETH Zurich Prof. dr. H.R. Waterham AMC-UvA Dr. F.M. Wensveen University of Rijeka, Croatia

Faculteit der Geneeskunde

“The world is changed. I feel it in the water. I feel it in the earth. I smell it in the air. Much that once was is lost; for none now live who remember it.”

J.R.R Tolkien

Table of content

Chapter 1 Introduction 9 Eur. J. Immunol. 2015; 45:2433–2445.

Chapter 2 Blimp-1homologHobitidentifieseffector-typelymphocytesin 31 humans. Eur. J. Immunol. 2015; 45:2433–2445 Chapter 3 ThetranscriptionfactorHobitidentifieshumancytotoxic 57 CD4Tcells FrontiersinImmunology.inpress

Chapter 4 Hobitregulatesmetabolismandmaintenanceofhumancytotoxic77 lymphocytes Chapter 5 Hobitbutnotblimp-1maintainscytotoxicityinmemory 99 CD8Tcells

Chapter 6 Hobitregulateshumannaturalkillercelldevelopmentand 123 effectorfunction

Chapter 7 TheAdhesionGProtein-CoupledReceptorGPR56/ADGRG1Isan 139 InhibitoryReceptoronHumanNKCells CellRep.2016;15:1757–1770.

Chapter 8 GeneralDiscussion 173

Appendix EnglishSummary 184 NederlandseSamenvatting 187 Listofco-authorsandtheircontributiontothemanuscript 190 PhDportfolio 192 Listofpublications 194 Curriculum Vitae 195 Acknowledgments 196