uva-dare (digital academic repository) innovating image ...surgery: fine tuning hybrid surgical...

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Innovating image-guided surgery: Introducing multimodal approaches for sentinel nodedetection

Brouwer, O.R.

Link to publication

Citation for published version (APA):Brouwer, O. R. (2013). Innovating image-guided surgery: Introducing multimodal approaches for sentinel nodedetection.

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PhD Portfolio

PhD student: Oscar Roberto Brouwer PhD period 06/2010 – 12/2012

PhD supervisors:

prof. dr. A.J.M. Balm, prof. dr. S. Horenblas dr. R.A. Valdés Olmos, dr. F.W.B. van Leeuwen, dr. O.E. Nieweg

254 | PhD Portfolio254 | Innovating image-guided surgery: Introducing multimodal approaches for sentinel node detection

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Publications

1. SPECT/CT and a portable gamma camera for image guided laparoscopic sentinel node biopsy in testicular cancer. Brouwer OR, Valdés Olmos RA, Vermeeren L, Hoefnagel CA, Nieweg OE, Horenblas S. J Nucl Med. 2011;52:551-4.

2. Evaluation of the sentinel lymph node combining SPECT/CT with the planar image and its importance for the surgical act. Vidal -Sicart S, Brouwer OR, Valdés Olmos RA. Rev Esp Med Nucl Imagen Mol. 2011;30:331–7.

3. Laparoscopic sentinel lymph node biopsy for prostate cancer: the relevance of lo-cations outside the extended dissection area. Meinhardt W, van der Poel HG, Valdés Olmos RA, Bex A, Brouwer OR, Horenblas S. Prostate Cancer. 2011;2012:1–4.

4. Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients; clinical proof of concept of an integrated functional imag-ing approach using a multimodal tracer. van der Poel HG, Buckle T, Brouwer OR, Valdés Olmos RA, van Leeuwen FWB. Eur Urol. 2011;60:826–33.

5. Local recurrence after skin sparing mastectomy. Brouwer OR, Donker M, Woerde-man LAE, Vrancken Peeters MTFD. Ned Tijdschr Geneeskunde. 2012;156:A4692.

6. Reply to K. Polom’s Letter to the Editor re: “Intraoperative Laparoscopic Fluorescence Guidance to the Sentinel Lymph Node in Prostate Cancer Patients: Clinical Proof of Concept of an Integrated Functional Imaging Approach Using a Multimodal Tracer. Eur Urol 2011;60:826–33.” van der Poel HG, Brouwer OR, van den Berg NS, Buck-le T, van Leeuwen FWB. Eur Urol. 2012;61:e19–e20.

7. Lymphatic drainage in prostate carcinoma assessed by lymphoscintigraphy and SPECT/CT: Its importance for the sentinel node procedure. de Bonilla-Damiá A, Brouwer OR, Meinhardt W, Valdés Olmos RA. Rev Esp Med Nucl Imagen Mol. 2012;31:66–70.

8. Image navigation as a means to expand the boundaries of fluorescence guided surgery: fine tuning hybrid surgical guidance. Brouwer OR, Buckle T, Bunschoten A, Kuil J, Vahrmeijer AL, Wendler T, Valdés Olmos RA, van der Poel HG, van Leeuwen FWB. Phys Med Biol. 2012;57:3123–36.

9. Decisive role of SPECT/CT to localize unusual periscapular sentinel nodes in patients with posterior trunk melanoma: Three illustrative cases and a review of literature. Avarez Paez M, Brouwer OR, Veenstra HJ, van der Hage JA, Wouters M, Nieweg OE, Valdés Olmos RA. Melanoma Res. 2012;22:278–83.

10. Feasibility of sentinel node biopsy in head and neck melanoma using a hybrid radi-oactive and fluorescent tracer. Brouwer OR, Klop WMC, Buckle T, Vermeeren L, van den Brekel MWM, Balm AJM, Nieweg OE, Valdés Olmos RA, van Leeuwen FWB. Ann Surg Oncol. 2012;19:1988–94.

11. De schildwachtklierprocedure bij prostaatkanker: huidige ervaring en ontwikkelingen. Brouwer OR, van Leeuwen FWB, van der Poel HG, Valdés Olmos RA, Meinhardt W. Nederlands Tijdschr Urologie. 2012;28:1–8.

PhD Portfolio | 255Chapter 14: PhD Portfolio | 255

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12. Relation between intraprostatic tracer deposits and sentinel lymph node mapping in prostate cancer patients. Buckle T, Brouwer OR, Valdés Olmos RA, van der Poel HG, van Leeuwen FWB. J Nucl Med. 2012 Jul;53:1026–33.

13. Comparing the hybrid fluorescent-radioactive tracer indocyanine green-99mTc-nano-colloid with 99mTc-nanocolloid for sentinel node identification: a validation study using lymphoscintigraphy and SPECT/CT. Brouwer OR, Buckle T, Vermeeren L, Klop WMC, Balm AJM, van der Poel HG, van Rhijn BW, Horenblas S, Nieweg OE, van Leeuwen FWB. J Nucl Med. 2012;53:1034–40.

14. Lymphoscintigraphy and SPECT/CT in multicentric and multifocal breast cancer: does each tumour have a separate drainage pattern? Results of a Dutch Multicenter Study (MULTISENT). Brouwer OR, Vermeeren L, van der Ploeg IMC, Valdés Olmos RA, Loo CE, Pereira-Bouda LM, Smit F, Neijenhuis P, Vrouenraets BC, Sivro-Prn-delj F, Jap A Joe SM, Rutgers EJth, Oldenburg HSA. Eur J Nucl Med Mol Imaging. 2012;39:1137–43.

15. A hybrid tracer for concomitant radio- and fluorescence guided sentinel lymph node biopsy in oral cavity cancer. van den Berg NS, Brouwer OR, Klop WMC, Balm AJM, van den Brekel MWM, Valdés Olmos RA, van Leeuwen FWB. Eur J Nucl Med Mol Imaging. 2012;39:1128–36.

16. Five-year follow-up of 16 melanoma patients with a Starz I-involved sentinel node in whom completion lymph node dissection was omitted. Veenstra HJ, Brouwer OR, van der Ploeg IMC, Kroon BBR, Nieweg OE. Melanoma Res. 2012;22:436–9.

17. De schildwachtklierprocedure en SPECT-CT. Valdés Olmos RA, Brouwer OR, Feen-stra C. Gamma Professional. 2012;4:13-8.

18. Sentinel node identification with a portable gamma camera in a case without visual-ization on conventional lymphoscintigraphy and SPECT/CT. Vidal-Sicart S, Brouwer OR, Mathéron HM, Bing Tan I, Valdés Olmos RA. Rev Esp Med Nucl Imagen Mol. 2013;32:203–4.

19. Added value of the hybrid tracer indocyanine green-(99m)Tc-nanocolloid for sentinel node biopsy in a series of patients with different lymphatic drainage patterns. Fron-tado ML, Brouwer OR, van den Berg NS, Mathéron HM, Vidal-Sicart S, van Leeuwen FWB, Valdés Olmos RA. Rev Esp Med Nucl Imagen Mol. 2013; In press.

20. Lymphatic drainage from renal cell carcinoma along the thoracic duct visualized with SPECT/CT. Brouwer OR, Noe A, Valdés Olmos RA, Bex A. Lymphatic Res Biol. 2013; Submitted.

21. A hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye. Brouwer OR, van den Berg NS, Mathéron HM, van der Poel HG, van Rhijn BW, van Tinteren H, Valdés Olmos RA, van Leeuwen FWB, Horenblas S. Eur Urol. 2013; Submitted.

22. Image-guided sentinel node biopsy in 104 melanoma patients: a hybrid approach. Brouwer OR, van den Berg NS, Schaafsma BE, Mathéron HM, Klop WMC, Balm AJM, van Tinteren H, Nieweg OE, van Leeuwen FWB, Valdés Olmos RA. Ann Surg. 2013; Submitted.


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23. Sentinel node biopsy guided by 3D SPECT/CT-based navigation: transferring molec-ular imaging to the operating room. Brouwer OR, van den Berg NS, Mathéron HM, Wendler T, van der Poel HG, Horenblas S, Valdés Olmos RA, van Leeuwen FWB. J Nucl Med. 2013: Submitted.

book chaPters:

Gostt in testicular cancer. Brouwer OR, Horenblas S, Nieweg OE, Valdés Olmos RA. In: Guided Intraoperative Scintigraphic Tumour Targeting (GOSTT), International Atomic Energy Agency (IAEA), 2011.

Gostt in Prostate cancer. Valdés Olmos RA, Meinhardt W, Vermeeren L, Brouwer OR. In: Guided Intraoperative Scintigraphic Tumour Targeting (GOSTT), International Atomic Energy Agency (IAEA), 2011.

Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in kidney and bladder cancers. Bex A, Brouwer OR, Valdés Olmos RA. In: Atlas of Lymphoscintigraphy and Sentinel Lymph Node Mapping, Springer, 2012.

Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in head and neck cancers. Valdés Olmos RA, Klop WMC, Brouwer OR. In: Atlas of Lymphoscintigraphy and Sentinel Lymph Node Mapping, Springer, 2012.

Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the male reproductive system. Brouwer OR, Meinhardt W, Valdés Olmos RA, Horenblas S. In: Atlas of Lymphoscintigraphy and Sentinel Lymph Node Mapping, Springer, 2012.

Presentations

sPect/ct to localize sentinel nodes in prostate cancer with uncommon lymphatic drainage. Brouwer OR, Vermeeren L, Meinhardt W, Bex A, van der Poel HG, Valdés Olmos RA. 7th International Sentinel Node Society Meeting, Nov. 2010, Yokohama, Japan. Oral presentation.

initial experience with 3D intraoperative freehand sPect probe imaging for radioguided tumor excision and sentinel node biopsy in breast cancer. Brouwer OR, van der Hage J, Wendler T, Valdés Olmos RA. T7th International Sentinel Node Society Meeting, Nov. 2010, Yokohama, Japan. Oral presentation.


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Gecombineerde preoperatieve schildwachtklierlocalisatie met beeldgeleide schildwachtklierbiopsie in patiënten met een hoofdhalsmelanoom. Brouwer OR, Klop WMC, Buckle T, Vermeeren L, van den Brekel MWM, et al. Dutch Society of Otolaryngology (KNO) Scientific Meeting, Apr. 2011, Nieuwegein, NL. Oral presentation.

initial clinical validation of a multimodal radioactive / fluorescence imaging agent for simultaneous radioguided and optical sentinel node detection. Brouwer OR, Buckle T, Vermeeren L, Klop WMC, Balm AJM, et al. Dutch Nuclear Medicine Society (NVNG) Scientific Meeting, Apr. 2011, Utrecht, NL. Oral presentation.

sPect/ct and a portable gamma camera for image guided sentinel node biopsy in testicular cancer and renal cell carcinoma. Brouwer OR, Bex A, Horenblas S, Meinhardt W, van der Poel HG, Hoefnagel CA, Nieweg OE, Vermeeren L, Valdés Olmos RA. Innovating Radioguided Surgery Forum, May 2011, Amsterdam, NL. Oral presenta-tion.

Multimodal icG-99mtc-nanocolloid for synchronous fluorescence/radioguided sentinel node detection. Brouwer OR, van Leeuwen FWB. Innovating Radioguided Surgery Forum, May 2011, Amsterdam, NL. Oral presenta-tion.

Gecombineerde preoperatieve schildwachtklierlokalisatie en fluorescentiegeleide robotgeassisteerde schildwachtklier biopsie in prostaat kanker patiënten. Brouwer OR, van der Poel HG, Buckle T, Valdés Olmos RA, van Leeuwen FWB. Dutch Urology Society (NVU) Scientific Meeting, May 2011, Nieuwegein, NL. Plenary presentation.

clinical introduction of a multimodal radioactive / fluorescence imaging agent for simultaneous radiogu-ided and optical sentinel node detection. Brouwer OR, Buckle T, Klop WMC, Balm AJM, van der Poel HG, et al. European Society of Molecular Imaging Congress, Jun. 2011, Leiden, NL. Oral presentation.

3D intraoperative freehand sPect probe imaging for radioguided tumor excision and sentinel node biopsy in breast cancer. Brouwer OR, van der Hage J, Wendler T, Valdés Olmos RA. European Society of Molecular Imaging Congress, Jun. 2011, Leiden, NL. Poster presentation.

combined preoperative lymphatic mapping with real time intraoperative fluorescence guidance to the sentinel lymph node in head and neck melanoma patients. Brouwer OR, Klop WMC, Buckle T, Vermeeren L, van den Brekel MWM, et al. European Society of Molecular Imaging Congress, Jun. 2011, Leiden, NL. Poster presentation.


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assessment of lymphatic drainage patterns of a hybrid radioactive and fluorescent sentinel node tracer: a validation study using lymphoscintigraphy and sPect/ct. Brouwer OR, Buckle T, Klop WMC, Balm AJM, van der Poel HG, et al. European Nuclear Medicine Association Congress, Nov. 2011, Birmingham, UK. Oral presentation.

synchronous radio- and fluorescence guided sentinel node biopsy in head and neck melanoma. Brouwer OR, Klop WMC, Buckle T, van den Brekel MWM, Balm AJM, et al. European Nuclear Medicine Association Congress, Nov. 2011, Birmingham, UK. Oral presentation.

lymphoscintigraphy and sPect/ct in multicentric and multifocal breast cancer: does each tumour have a separate lymphatic drainage pattern? Brouwer OR, Vermeeren L, van der Ploeg IMC, Valdés Olmos RA, Loo CE, et al. European Nuclear Medicine Association Congress, Nov. 2011, Birmingham, UK. Oral presentation.

is de lokatie van intraprostatische tracer toediening van invloed op het lymfedrainage patroon? - ana-lyse met behulp van een hybride tracer. Brouwer OR, Buckle T, Valdés Olmos RA, van Leeuwen FWB, van der Poel HG. Dutch Urology Society (NVU) Meeting, Nov. 2011, Hengelo, NL. Oral presentation.

Gecombineerde radio- en fluorescentiegeleide schildwachtklierbiopsie in patiënten met een peniscarci-noom ter vervanging van patent blauw? Brouwer OR, van Leeuwen FWB, van der Poel HG, van den Berg NS, van Rhijn BW, et al. Dutch Urology Society (NVU) Meeting , Nov. 2011, Hengelo, NL. Oral presentation.

een hybride radioactieve en fluorescente tracer voor gecombineerde preoperatieve sentinelnodelokalisa-tie met beeldgeleide sentinelnodebiopsie. Brouwer OR, Buckle T, Vermeeren L, Klop WMC, Balm AJM, et al. Dutch Surgery Society (NvvH) Meeting, Nov. 2011, Ede, NL. Oral presentation.

a hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye? Brouwer OR, van der Poel HG, van den Berg NS, van Rhijn BW, Bex A, et al. European Association of Urology Annual Congress, Feb. 2012, Paris, France. Oral presentation.

can hybrid imaging agents also help determine if the location of intraprostatic tracer deposits affect sentinel node mapping in prostate cancer patients? Brouwer OR, Buckle T, Valdés Olmos RA, van der Poel HG, van Leeuwen FWB. European Association of Urology Annual Congress, Feb. 2012, Paris, France. Oral presentation.

tumour-related lymphatic mapping in multifocal/multicentric breast cancer: each tumour shows an individual drainage pattern. Brouwer OR, Vermeeren L, van der Ploeg IMC, Valdés Olmos RA, Loo CE, et al. 8th European Breast Cancer Conference, Mar. 2012, Vienna, Austria. Poster pres-entation.


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a hybrid radioactive and fluorescent tracer for sentinel node biopsy in head and neck melanoma. Brouwer OR, Klop WMC, Buckle T, Vermeeren L, Nieweg OE, et al. Society of Surgical Oncology Congress, Mar. 2012, Orlando, USA. Poster presenta-tion.

beeldgeleide navigatie tijdens uro-oncologische interventies: eerste resultaten van een pilot studie. Brouwer OR, Wendler T, Valdés Olmos RA, van Leeuwen FWB, van der Poel HG. Dutch Urology Society (NVU) Meeting, May 2012, Den Bosch, NL. Plenary presenta-tion.

clinical evaluation of a hybrid radioactive and fluorescent tracer for sentinel node biopsy in head and neck malignancies. Brouwer OR, Klop WMC, van den Berg NS, van den Brekel MWM, Balm AJM, et al. 5th International Symposium on SN Biopsy in Head/Neck Cancer, May 2012, Am-sterdam, NL. Oral presentation.

sPect/ct navigation as a means to improve the accuracy of radio- and fluorescence guided surgery. Brouwer OR, Buckle T, Bunschoten A, Kuil J, Vahrmeijer AL, et al. Society of Nuclear Medicine Congress, Jun. 2012, Miami, USA. Poster presentation.

lymphatic drainage patterns of a hybrid radioactive and fluorescent tracer for sentinel node procedures: a validation study using lymphoscintigraphy and sPect/ct. Brouwer OR, Buckle, T, Vermeeren L, Klop WMC, Balm AJM, et al. Society of Nuclear Medicine Congress, Jun. 2012, Miami, USA. Oral presentation.

hybrid radio- and fluorescence guided sentinel node biopsy in melanoma. Brouwer OR, van den Berg NS, Shaafsma BE, Klop WMC, Balm AJM, et al. World Molecular Imaging Congress, Sep. 2012, Dublin, Ireland, Oral presentation.

evaluation of a hybrid tracer for image-guided sentinel node biopsy in penile carcinoma. Brouwer OR, van den Berg NS, van der Poel HG, Horenblas S, Valdés Olmos RA, et al. World Molecular Imaging Congress, Sep. 2012, Dublin, Ireland, Poster presentation.

Feasibility of 3D intraoperative freehand sPect imaging for radioguided tumour excision and sentinel node biopsy in breast cancer. Brouwer OR, van den Hage J, Nieweg OE, Wendler T, van Leeuwen FWB, et al. European Society of Surgical Oncology Congress, Sep. 2012, Valencia, Spain. Oral presentation.

hybrid radio- and fluorescence guided sentinel node biopsy in melanoma. Brouwer OR, van den Berg NS, Schaafsma BE, Klop WMC, Balm AJM, et al. European Society of Surgical Oncology Congress, Sep. 2012, Valencia, Spain. Oral presentation.

3D Freehand sPect for radioguided tumor excision and sentinel node biopsy in breast cancer. Brouwer OR, van der Hage J, van Leeuwen FWB, Wendler T, Valdés Olmos RA. European Nuclear Medicine Association Congress, Oct. 2012, Milan, Italy. Oral presentation.


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intraoperative hybrid navigation based on sPect/ct: transferring molecular imaging to the operating room. Brouwer OR, van den Berg NS, Mathéron HM, van Leeuwen FWB, Valdés Olmos RA. European Nuclear Medicine Association Congress, Oct. 2012, Milan, Italy. Oral presentation.

image-guided sentinel node biopsy in penile carcinoma patients: a hybrid approach. Brouwer OR, van den Berg NS, van der Poel HG, Horenblas S, van Leeuwen FWB, et al. European Nuclear Medicine Association Congress, Oct. 2012, Milan, Italy. Oral presentation.

evaluation of a hybrid radioactive and fluorescent tracer for sentinel node biopsy in melanoma. Brouwer OR, van den Berg NS, Schaafsma BE, Mathéron HM, Klop WMC, et al. European Nuclear Medicine Association Congress, Oct. 2012, Milan, Italy. Oral presentation.

total ECTS: 16

teachinG

lectures:

Detectie en lokalisatie van de sentinel node: basale principes en innovaties.

17e Paramedisch Symposium, May 2011, Amsterdam, Netherlands. (ECTS 0.1)

Biopsia del ganglio centinela de carcinoma de pene y la experiencia en el uso de la

camera gamma portatil Sentinella.

Servicio de urologia y medicina nuclear, Hospital Almenara, August 2011, Lima,

Peru. (ECTS 0.1)

De schildwachtklierprocedure bij prostaatkanker.

Radiotherapy Department, NKI-AVL, Oct. 2011, Amsterdam, NL. (ECTS 0.1)

student mentoring:

Hanna Mathéron (6 months scientific internship); NKI-AVL, Amsterdam, NL. (ECTS 2)

Lisette Zeegers (3 months scientific internship); NKI-AVL, Amsterdam, NL. (ECTS 1)

courses

2010 Weekly sentinel node meeting, 2010-2012, NKI-AVL, Amsterdam, NL.

(ECTS 2)

2010 Biostatistics, NKI-AVL, Amsterdam, NL. (ECTS 2)

2012 How to write a manuscript and get it published. EAU Congress, Paris,

France. (ECTS 0.1)


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awarDs anD noMinations

2008 MSc. dissertation award, Nijbakker Morra stichting

2011 Nomination Young Investigator Award, European Society of Molecular Imaging Nomination Marie Curie Award, European Society of Nuclear Medicine Vlietstraprijs (Best presentation at Annual Meeting), Nederlandse Vereniging voor Urologie

2012 Best Abstract prize (Oncology), European Association of Urology SNM Travel Award, Society of Nuclear Medicine Nominatation Vlietstraprijs, Nederlandse Vereniging voor Urologie

uva-dare (digital academic repository) innovating image ...surgery: fine tuning hybrid surgical...

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