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Lung-protective ventilation in intensive care unit and operation roomTidal volume size, level of positive end-expiratory pressure and driving pressureSerpa Neto, A.

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Citation for published version (APA):Serpa Neto, A. (2017). Lung-protective ventilation in intensive care unit and operation room:Tidal volume size, level of positive end-expiratory pressure and driving pressure.

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Download date:02 Aug 2021

LUNG-PROTECTIVE VENTILATION IN INTENSIVE CARE UNIT AND OPERATION ROOM – TIDAL VOLUME

SIZE, LEVEL OF POSITIVE END-EXPIRATORY PRESSURE AND DRIVING PRESSURE

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor

aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie,

in het openbaar te verdedigen in de Agnietenkapel

op vrijdag 15 september 2017, te 14.00 uur

door Ary Serpa Neto

geboren te São Paolo, Brazilië

Promotiecommissie:

Promotores: prof. dr. M.J. Schultz AMC - Universiteit van Amsterdam

prof. dr. P. Pelosi Università degli studi di Genova

Copromotores: prof. dr. M. Gama de Abreu Technische Universität Dresden

dr. S.N.T. Hemmes AMC - Universiteit van Amsterdam

Overige leden: prof. dr. N.P. Juffermans AMC - Universiteit van Amsterdam

prof. dr. A.M. Pesenti University of Milan

prof. dr. B. Preckel AMC - Universiteit van Amsterdam

prof. dr. P.R.M. Rocco University of Rio de Janeiro

prof. dr. A.S. Slutsky University of Toronto

prof. dr. J.B.M. van Woensel AMC - Universiteit van Amsterdam

Faculteit der Geneeskunde

Contents

GENERAL INTRODUCTION Chapter 1

General introduction and outline of the thesis

05

Chapter 2 Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: A meta-analysis JAMA 2012;308(16):1651-9

19

Chapter 3 Dissipated energy is a key mediator of VILI: Rationale for using low driving pressures Annual Update in Intensive Care and Emergency Medicine 2016;1:311-22

63

VENTILATION DURING GENERAL ANESTHESIA FOR SURGERY Chapter 4

Incidence of mortality and morbidity related to postoperative lung injury in patients who have undergone abdominal or thoracic surgery: A systematic review and meta-analysis Lancet Respir Med 2014;2(12):1007-15

81

Chapter 5 Optimizing the settings on the ventilator settings: High PEEP for all? JAMA 2017;317(14):1413-4

123

Chapter 6 Association between driving pressure and development of postoperative pulmonary complications in patients undergoing mechanical ventilation for general anaesthesia: A meta-analysis of individual patient data Lancet Respir Med 2016;4(4):272-80

131

Chapter 7 Kinetics of plasma biomarkers of inflammation and lung injury in surgical patients with or without postoperative pulmonary complications Eur J Anaesthesiol 2017;34(4):229-38

177

VENTILATION IN CRITICALLY ILL PATIENTS WITHOUT ARDS Chapter 8

Ventilation with lower tidal volumes for critically ill patients without the acute respiratory distress syndrome: A systematic translational review and meta-analysis Curr Opin Crit Care 2014;20(1):25-32

219

Chapter 9 Lung-protective ventilation with low tidal volumes and the occurrence of pulmonary complications in patients without acute respiratory distress syndrome: a systematic review and individual patient data analysis Crit Care Med 2015;43(10):2155-63

241

Chapter 10 Association between tidal volume size, duration of ventilation, and sedation needs in patients without acute respiratory distress syndrome: an individual patient data meta-analysis Intensive Care Med 2014;40(7):950-7

277

Chapter 11 Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study Lancet Respiratory Medicine 2016;4:882-93

305

Chapter 12 Potentially modifiable factors contributing to outcome in patients without ARDS under invasive mechanical ventilatory support – a secondary analysis of PRoVENT

359

Submitted for publication GAS-EXCHANGE SUPPORT IN CRITICALLY ILL PATIENTS WITH ARDS

Chapter 13

Extracorporeal life support – a ‘breath-taking’ technology Ann Am Thorac Soc 2014;11(5):799-801

399

Chapter 14 Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: A pooled individual patient data analysis Intensive Care Medicine 2016;42:1672-84

407

Chapter 15 Impact of ventilator settings in patients with ARDS undergoing extracorporeal carbon dioxide removal: A pooled individual patient data analysis Submitted for publication

457

GENERAL DISCUSSION Chapter 16

Summary & general discussion

491

Chapter 17

Nederlandse samenvatting

505

APPENDICES Appendices

Contributing authors and affiliations Publications PhD Portfolio Parameters of esteem Curriculum Vitae Acknowledgments

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