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Novel aspects of innate immunity in human atherosclerosis and thrombosis

Pertiwi, K.R.

Publication date2020Document VersionOther versionLicenseOther

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Citation for published version (APA):Pertiwi, K. R. (2020). Novel aspects of innate immunity in human atherosclerosis andthrombosis.

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Download date:22 Jun 2021

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Novel A

spects of Inn

ate Imm

unity in

Hum

an A

therosclerosis and T

hrombosis

Kartika R

atna P

ertiwi

Kartika Ratna Pertiwi

Novel Aspects of Innate Immunity

in Human Atherosclerosis and

Thrombosis

Kartika Ratna Pertiwi

Novel Aspects of Innate Immunity

in Human Atherosclerosis and

Thrombosis

ColophonNovel Aspects of Innate Immunity in Human Atherosclerosis and Thrombosis

Academic Thesis, University of Amsterdam, the Netherlands

ISBN: 978-94-6380-827-9

Cover design: Kartika Ratna Pertiwi and Rara Wirastuti

Layout: Goodteadesign ‖ www.wirastuti.comPrinting: ProefschriftMaken ‖ www.proefschriftmaken.nl

This thesis was accomplished with financial support from the Indonesian Endowment

Fund for Education (Lembaga Pengelola Dana Pendidikan), Ministry of Finance, Republic

of Indonesia.

Financial support by the Dutch Heart Foundation for the publication of this thesis is

gratefully acknowledged. Additional financial support for the printing of this thesis

was kindly provided by the Department of Pathology, Amsterdam UMC, location AMC,

University of Amsterdam, the Netherlands.

Copyright © 2020 Kartika Ratna Pertiwi

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system,

or transmitted in any form or by any means without written permission of the author or,

when appropriate, of the publishers of the publication.

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor

aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie,

in het openbaar te verdedigen

op dinsdag 23 juni 2020, te 14.00 uur

door

Kartika Ratna Pertiwi

geboren te Yogyakarta

Novel Aspects of Innate Immunity

in Human Atherosclerosis and

Thrombosis

Promotiecommissie

Promotor: prof. dr. A.C. van der Wal AMC-UvA

Copromotor: dr. O.J. de Boer AMC-UvA

Overige leden: dr. M. Meuwissen Amphia Ziekenhuis

prof. dr. M.J.A.P. Daemen AMC-UvA

prof. dr. S. Florquin AMC-UvA

prof. mr. dr. B.A.J.M. de Mol AMC-UvA

prof. dr. J.W.M. Niessen Vrije Universiteit Amsterdam

prof. dr. A. Angelini Università degli Studi di Padova

prof. dr. M.P.J. de Winther AMC-UvA

Faculteit der Geneeskunde

“So, verily, with every difficulty, there is a relief”

(Quran 94:5)

This thesis is dedicated to my family, for their endless love, support and pray,

and for them I always remember why I start this PhD journey

Chapter 1 General Introduction 9Chapter 2 Neutrophil extracellular traps participate in all

different types of thrombotic and haemorrhagic complications of coronary atherosclerosis Thrombosis and Haemostasis, 2018;118(06):1078-1087

25

Chapter 3 Extracellular traps derived from macrophages, eosinophils, mast cells and neutrophils occur are generated in a time-dependent manner during atherothrombosis The Journal of Pathology, 2019;247(4):505-512

47

Chapter 4 Etosis, rather than apoptosis or cell proliferation, typifies thrombus progression – an immunohistochemical study of coronary aspiratesInternational Journal of Cardiology Heart and Vasculature, 2020:20;100439-100446

67

Chapter 5 Immunophenotypic analysis of the chronological events of tissue repair in aortic medial dissectionsCardiovascular Pathology, 2018;34:9–14

87

Chapter 6 Novel players in human atherosclerotic plaque inflammation: Innate lymphoid cells are present in all developmental stages of plaque formationSubmitted

103

Chapter 7 Histopathological thrombus study in large vessel occlusion related stroke and ST-segment elevation myocardial infarction: similarities, differences, and prognostic implicationsSubmitted

121

Chapter 8 Summary and DiscussionNederlandse Samenvatting en DiscussieRingkasan dan PembahasanList of All References

139146154164

Chapter 9 AppendixList of Contributing AuthorsPhD PortfolioList of PublicationsAcknowledgementCurriculum Vitae

177178180184187194

TABLE OF CONTENTS