valley of death panel slides at the partnering for cures conference, december 2, 2009
DESCRIPTION
A panel at the inaugural Partnering for Cure conference spotlights the translational funding and management gap in biomedical research and development. Moderator: Sharon Begley, Science Editor, NewsweekPanelists:Robi Blumenstein, President, CHDI Management/CHDI FoundationRandall Carpenter, Co-Founder, President and Chief Executive Officer, Seaside TherapeuticsDennis Purcell, Managing Partner, Aisling CapitalAmy Comstock Rick, Chief Executive Officer, Parkinson's Action NetworkChristian Loucq, PATH Malaria Vaccine InitiativeTRANSCRIPT
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Crossing the Valley of Death: The Translational Funding Crossing the Valley of Death: The Translational Funding and Management Gapand Management Gap
Moderator: Sharon Begley, Science Editor, Newsweek
Panelists:• Robi Blumenstein, President, CHDI Management/CHDI Foundation• Randall Carpenter, Co-Founder, President and Chief Executive Officer,
Seaside Therapeutics• Dennis Purcell, Managing Partner, Aisling Capital• Amy Comstock Rick, Chief Executive Officer, Parkinson's Action Network• Christian Loucq, PATH Malaria Vaccine Initiative
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Brain Developmental
Disorders
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Translating the mGluR Theory into Novel Therapeutics
Scientific Discovery
Druggable Targets
Efficacy in Model System
Candidate Drug
IND-enabling Research
Human Trials
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Seaside Therapeutics Model
• Venture Philanthropy Seed Funding
• Core Competency in Translational Medicine
• Collaborative Business Model– Foundations – FRAXA, Autism Speaks, NFXF
– Merck & Co, Inc. – R&D Collaboration
– NIH UO1 Translational Research Cooperative Agreement• NIMH, NICHD, BPCA, NINDS, FRAXA & Autism Speaks
– Baylor Medical Center – Behavioral Research
– Vanderbilt University – Drug Discovery
– Correlagen Diagnostics – Companion Diagnostic
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Basic Research
Prototype Design or Discovery
Preclinical Development
Clinical DevelopmentFDA Filing/ Approval &
Launch Preparation
The Development Pipeline and Valley of Death
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Basic Research
[Mostly NIH Funded]
Prototype Design or Discovery
Preclinical Development
Clinical Development[Mostly Large Pharma]
FDA Filing/ Approval &
Launch Preparation
The Development Pipeline and Valley of Death
[Inconsistent Funding]
[Inconsistent Funding]
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The Development Pipeline and Valley of DeathVarious Solutions
Prototype Design or Discovery
Preclinical Development
Clinical Development[Mostly Large Pharma]
FDA Filing/ Approval &
Launch Preparation
Private Foundation Research
NIH - SBIR
Venture Philanthropy
[Inconsistent Funding]
[Inconsistent Funding]
NIH – CTSA’s
TATRC
Basic Research
[Mostly NIH Funded]
TRND