vapour shipper manual - phri · 2015-02-13 · • shipping documents for shipment to phri/canada...

Dry Shipper Manual

Shipment of Diagnostic Specimens Using a Dry Shipper Model XC20/3V

Population Health Research Institute Affiliated with McMaster University and Hamilton Health Sciences Corporation Update: February 2008

TABLE OF CONTENTS SECTION 1 - BACKGROUND INFORMATION ON DRY SHIPPERS .................................. 1

SECTION 2 - RECEIPT OF DRY SHIPPER ............................................................................... 1 2.1 INSPECTING THE DRY SHIPPER ............................................................................................. 1 2.2 INSIDE THE DRY SHIPPER ..................................................................................................... 1 2.4 DRY SHIPPER ACCESSORIES ................................................................................................. 1

SECTION 3 - SAFETY WHILE WORKING WITH LIQUID NITROGEN ............................ 2

SECTION 4 – SEND DRY SHIPPER TO PHRI CENTRAL LAB ............................................ 2 4.1 WELL IN ADVANCE OF EXPECTED SHIPPING DATE: ............................................................. 2 4.2 WHEN TO SHIP ..................................................................................................................... 3 4.3 24 HOURS BEFORE SHIPMENT .............................................................................................. 3 4.4 ON DAY OF SHIPMENT ......................................................................................................... 4 4.5 INSERTING SPECIMENS INTO THE DRY SHIPPER .................................................................... 4 4.6 DRIED BLOOD SPOTS/FILTER PAPERS .................................................................................. 4

SECTION 5 – SHIPMENT DOCUMENTATION AND ADDRESS LABELS ......................... 5

SECTION 6 - REPORTING THAWED SPECIMENS TO PHRI ............................................. 6

SECTION 7 - USING THE CABOSIL INSERT TO INCREASE DRY SHIPPER HOLDING TIME ......................................................................................................................... 6

SECTION 8 - USING THE DRY SHIPPER FOR SPECIMEN STORAGE ............................. 7

SECTION 9 - PHRI CONTACT INFORMATION ..................................................................... 7

APPENDICES I Dry Shipper Characteristics .............................................................................................. 8 II Documentation Confirming Dry Shipper Non-Dangerous Status for Shipping ............... 9 III Material Safety Data Sheet – Liquid Nitrogen ............................................................... 10 IV Sample Commercial Invoice ........................................................................................... 13 V Preprinted Air Waybill (AWB) ....................................................................................... 14 VI Notice of Shipment – may be copied .............................................................................. 15

Section 1 - Background Information on Dry Shippers

Dry shippers are prepared for shipment by filling with liquid nitrogen, which is absorbed into the lining. Liquid nitrogen not absorbed after 24 hours is poured off before shipping. The shipper is called a “dry” shipper because it no longer contains a liquid. Approximately 20 litres of liquid nitrogen are required to fill the dry shipper. A properly prepared Dry Shipper is not considered to be a Dangerous Good, and is not restricted. It does not contain liquid nitrogen. It does contain vaporous nitrogen. The Dry Shipper will keep specimens frozen at –150oC for at least 10 days ensuring sufficient time for delivery to PHRI Central Lab in Canada. If liquid nitrogen is visible in the bottom of the Dry Shipper at the time of shipment it is not eligible for shipment by air. The Hamilton Regional Lab Medicine Program (HRLMP), Research Lab receives the Dry Shippers, inspect, store and analyze the specimens, and is the Central Lab. It is acceptable to ship specimens for multiple PHRI studies together in one Dry Shipper. Section 2 - Receipt of Dry Shipper 2.1 Inspecting the Dry Shipper

Upon arrival, remove the Dry Shipper from the protective plastic shipping case. Inspect the case, and the Dry Shipper for damage. Please contact PHRI immediately if you identify damage.

2.2 Inside the Dry Shipper Each Dry Shipper contains the following when shipped. Please inspect the inside of the Dry Shipper to confirm you have received:

• Shipping documents for shipment to PHRI/Canada with frozen specimens FedEx Air Waybill, preprinted with address for PHRI Central Lab, account #, and plastic AWB pouch (please discard if you use alternate courier)

• Documentation stating that Dry Shippers are not dangerous goods (Appendix) • Shipping labels with instruction for use

o PHRI address labels o other labels as may be required by shipping regulations.

• Notice of Shipment form (to be faxed/emailed to PHRI at time of shipment)

2.3 Dry Shipper Accessories You will receive the following in a separate box with the first Dry Shipper sent to you. Please return all except the manuals and safety goggles to PHRI with your final specimen shipment.

• 1 Dry Shipper Manual (this manual) • 1 pair cryogloves

• 2 pairs of safety goggles • 1 plastic measuring stick

Section 3 - Safety While Working with Liquid Nitrogen

Liquid nitrogen freezes human tissue on contact and can cause severe burns. • Position the empty Dry Shipper in a location out of the traffic flow where it will not be

disturbed • Ensure that your body is protected when working with liquid nitrogen:

o feet are protected by closed shoes o legs and arms are protected by adequate clothing o body protected by wearing a laboratory coat or cryoapron o protect eyes by wearing goggles, or face shield o protect hands and lower arms with cryogloves

• Fill the Dry Shipper with a funnel or transfer line when possible. 15 to 20 litres of liquid

nitrogen are required, depending upon the evaporation rate during filling. • Fill with liquid nitrogen slowly and allow the nitrogen to gradually lower the temperature

of the Dry Shipper. This will require 15 to 20 minutes, depending upon the capacity of the transfer line.

• Avoid spilling liquid nitrogen over the vacuum cap near the neck as this can shrink the seal and allow air to leak into the vacuum space. The vacuum cap is protected by a black rubber cap.

• Immediately remove any clothing or safety attire on which liquid nitrogen has spilled. • Get immediate medical attention for any frostbite injuries due to liquid nitrogen • Always keep the Dry Shipper in an upright position • Read the Material Safety Data Sheets in Appendix before using liquid nitrogen

Pouring liquid nitrogen into a warm or room-temperature Dry Shipper too quickly will cause the nitrogen to “boil over” or splash out the top of the Dry Shipper, possibly splashing the user. USE CAUTION AT ALL TIMES. WARNING: The venting of nitrogen vapours can deplete oxygen in the air, possibly leading to asphyxiation or even death. Do not store or use liquid nitrogen or Dry Shippers filled with liquid nitrogen in areas that have poor ventilation. Section 4 – Send Dry Shipper to PHRI Central Lab

4.1 Well in Advance of Expected Shipping Date: a) Remove old air waybill, or stickers with air waybill #s from the protective plastic

case.

b) Contact local Customs/Export Officials to determine the local permits/documents required to accompany the specimens for export i.e. Ministry of Health permits, letter from investigator declaring non-infectious status, etc.

c) Prepare customs documents/Commercial Invoice for export. Refer to the Appendix

for a blank commercial invoice, with completion instructions. An electronic template is available on the PHRI website http://www.phri.ca/diagnosticspecimen.htm.

d) In most cases PHRI specimens can be classified as EXEMPT HUMAN SPECIMENS, because they are not known or expected to be infectious, or to contain pathogens, and are not likely to be dangerous to those handling the shipment, or to the general public during transportation. This manual is in compliance with IATA 48th Edition 2007, Dangerous Goods Regulations. The XC 20/3V Dry Shipper can transport this classification of specimen.

If in the investigator’s opinion, the specimens are collected from a high-risk population and are known or likely to be infectious, the specimens are classified as UN3373 Biological Substance Category B, and cannot be shipped using the instructions in this manual. Please contact PHRI for additional assistance and an alternate shipping plan. Specimens from patients known or expected to be HIV+ are an example of the type of specimen to be shipped as UN3373.

4.2 When to Ship

The Dry Shipper will accommodate: 600 2mL vials if 5 canisters are used 480 2mL vials if 4 canisters are used • Specimens stored at –70oC or colder are to be shipped within 12 months of

collection/storage of first specimen. • Specimens stored between –20oC and –69oC, are to be shipped every 3 months. • Ship when 1 or more Dry Shippers can be filled with specimens • A maximum of 6 Dry Shippers can be shipped together. • Do not ship between December 15th and December 31st.

4.3 24 Hours before Shipment a) Review Section 3 - Safety While Working with Liquid Nitrogen b) Remove the Dry Shipper from the protective plastic shipping case. c) Open protective plastic case and lift the black cap from the Dry Shipper. (Do not

twist). d) Remove the centre canister and 4 side canisters from the Dry Shipper, and place in a

safe location until needed the next day. e) Slowly fill the unit to the bottom of the neck-tube with liquid nitrogen (approximately

14 inches from the bottom of the unit). Do not overfill, as this can cause damage to

the Dry Shipper. A plastic measuring stick is provided to assist with determining the level of the liquid nitrogen.

f) Remove filling hose. g) Replace the black cap and allow the liquid nitrogen to be absorbed by the unit lining

for a full 24 hours.

4.4 On Day of Shipment

a) Inspect Dry Shipper to ensure there is no frost or condensation on the outside of the unit. Some frost near the top just after filling is normal.

b) Remove the black cap. c) Pour out all liquid nitrogen not absorbed by the Dry Shipper. It is important that no

liquid nitrogen remains in the Dry Shipper. Liquid nitrogen is a dangerous good, and cannot be shipped in a Dry Shipper.

d) Replace the black cap. e) Weigh the Dry Shipper. f) If weight is > 35 lbs (16 kg), liquid nitrogen may be present. Check Dry Shipper to

ensure all liquid nitrogen has been removed. g) If weight <30 lbs (14 kg), or if there is visible damage, frost or heavy condensation on

the outside of the unit, it is likely the unit will not keep specimens frozen. Contact PHRI for further instruction.

h) If weight is between 30 lbs and 35 lbs (14 to 16 kg), continue with shipment procedure.

i) Place the Dry Shipper into the shipping case.

4.5 Inserting Specimens into the Dry Shipper

• Each aluminum cane will hold five 2 mL cryogenic storage vials • Each aluminum canister will hold 24 aluminum canes of specimens;

accommodating 120 specimens.

Take care that the storage vials remain frozen while being placed into the canes, and while the canes are placed into the canisters.

a) Remove 20 to 30 specimen storage vials from the freezer at a time. b) Place 5 storage vials into each aluminum cane, and 24 aluminum canes into each

canister. Handle canes and canisters slowly and carefully to ensure that the barcoded Specimen ID labels do not become damaged, and the storage vials do not become loose and drop to the bottom of the Dry Shipper.

c) Loose specimens may thaw before being located d) Place filled canister into Dry Shipper, put the black cap onto the Dry Shipper, and

proceed to fill next canister. e) When all canisters have been filled, replace the black cap, and close the protective

plastic case. f) Specimens are now ready for shipment.

4.6 Dried Blood Spots/Filter Papers

The processing of blood for study analysis often includes the preparation of a “dried blood spot” in addition to the aliquots in cryogenic storage vials. This type of specimen is often also referred to as a “filter paper”. These cannot be shipped in the dry shipper. Dried blood spots are shipped without refrigerant or cooling, in a sturdy cardboard box. Special packaging is not required. Please ensure an ‘EXEMPT HUMAN SPECIMEN” label is affixed to the box. Each dried blood spot on filter paper is to be enclosed in the individual sealed plastic pouch provided, to prevent damage, or contamination. Please ship dried blood spots at the same time as the corresponding aliquots in the Dry Shipper. This will result in a shipment of 2 or more pieces; 1 dry shipper and 1 box.

Section 5 – Shipment Documentation and Address Labels a) Confirm all old courier Air Waybills (AWB) and stickers with air waybill numbers

from previous shipments have been removed from the shipping case. b) Locate the envelope of shipping instructions, documents and labels shipped with the

empty dry shipper, inside the plastic shipping case. c) Place the address label for shipment to PHRI (Figure A) to cover the label showing

your address on top of plastic shipping case.

Figure A

d) Prepare Commercial Invoice. A sample with instructions, and a blank form suitable

for copying are provided in the Appendix, and a template in MS Word format is available at http://www.phri.ca/diagnosticspecimen.

e) Complete the FedEx Air Waybill as detailed in the example in the Appendix. Our usual courier is FedEx. Please contact PHRI if you cannot use FedEx and must use an alternate courier. Enter the study name and “DS” in the reference section of the Air Waybill. When shipping specimens for more than one study, use the name of the study with the greater number of specimens shipped.

f) Place all documents for courier and customs into the plastic AWB pouch • Completed Air Waybill (AWB)

SHIP TO: Population Health Research Institute Research Lab/HRLMP RAMP Location 237 Barton Street East Hamilton, Ontario CANADA L8L 2X2 DELIVER TO RAMP LOCATION

In case of accident or damage call 1-905-527-4322 ext. 44408/44326

FROZEN DIAGNOSTIC SPECIMENS

Please do not delay shipment

http://www.phri.ca/diagnosticspecimen

• Customs documents and permits meeting your country’s requirements • Original and 3 copies of Commercial Invoice • Dry Shipper documents provided by PHRI. A copy is found in the Appendix

for your reference g) Stick the plastic AWB pouch containing the documents onto the side of the protective

plastic case h) Affix other shipment labels as directed. i) Complete and fax the “Notice of Shipment in A Dry Shipper” form to the PHRI fax

number given on the form (See Appendix for example), or provide the same information by completing the Notice of Shipment section of the PHRI website http://www.phri.ca/diagnosticspecimen. This will allow PHRI to track the shipment and ensure it arrives within the window of safety to maintain the integrity of the specimens.

j) Place 1 copy of the Notice of Shipment Form inside the “first” dry shipper. k) Keep 1 copy of all documents on file at your site. Dry Shipper and specimens are now ready for pick-up by courier.

PHRI will contact you in the event of a problem with the shipment. PHRI will not contact you to confirm receipt of the shipment. Please contact PHRI any time you have concerns.

Section 6 - Reporting Thawed Specimens to PHRI

If specimens thaw at any time before shipment to PHRI:

• Place the specimens in a freezer • Contact the PHRI Research Coordinator for your study or email details to

[email protected]. • Be prepared to send a list of the barcode label numbers for the thawed specimens.

PHRI will respond with advice on how to proceed. Do not ship specimens that have thawed without advising PHRI. Section 7 - Using the Cabosil Insert to Increase Dry Shipper Holding Time PHRI tests Dry Shippers periodically to determine “holding time”, and uses units that will keep specimens frozen for a minimum of 10 days. If additional holding time is required, PHRI will include a Cabosil insert for the centre canister, for an increase in holding time up to 33%. The following steps are in addition to the procedure outlined in Sections 5.3 to 5.5 • Place the Cabosil insert inside the centre aluminum canister, and place inside the Dry Shipper. • Leave inside the Dry Shipper while filling with liquid nitrogen, and for 24 hours after filling

to absorb the liquid nitrogen.

http://www.phri.ca/diagnosticspecimen

mailto:[email protected]

• Remove canister and insert from the Dry Shipper temporarily while you pour-off non-absorbed liquid nitrogen, and while you fill the 4 outer canisters with specimens. Place in a freezer if possible.

• Replace canister in the centre of the Dry Shipper after all four outer canisters have been filled and placed inside the Dry Shipper.

Section 8 - Using the Dry Shipper for Specimen Storage • The Dry Shipper was primarily designed as a shipping container, however they can also be

used for storage of specimens. • Please contact PHRI if you wish to use the Dry Shipper for storage.

Section 9 - PHRI Contact Information For information on the use of Dry Shippers, or detail about your shipment, please contact:

Population Health Research Institute 237 Barton Street East Hamilton, Ontario Canada L8L 2X2 Tel: 1-905-527-4322 ext. 44408 or ext. 44326 Fax: 1-905-527-9642 Email: [email protected] Website: www.phri.ca//diagnosticspecimen.htm


Appendix I

Dry Shipper Characteristics

Each MVE XC20/3V Dry Shipper has the following characteristics: Weight, empty 23 lbs / 10 kg Weight, charged 35 lbs / 16 kg Weight, protective plastic shipping case 10 lbs / 4.5 kg Shipping weight (charged, with specimens and protective plastic case) 55 lbs / 25 kg Volume of liquid nitrogen required to fill; depends upon filling/vaporization rates

15 to 20 litres

Liquid nitrogen absorbed 6.8 litres Liquid nitrogen evaporation rate 0.39 litres per day Static Holding Time (if unopened) Maximum without Cabosil insert Maximum with Cabosil insert * PHRI tests Dry Shippers periodically; and uses units with a hold time of 10 days or more without the Cabosil insert

17 days 25 days

Height 24“ Diameter 18“ Capacity – 2 mL vials in aluminum canes 600 cryovials

Appendix II Population Health Research Institute

McMaster University,/Hamilton Health Sciences 237 Barton Street East

Hamilton, Ontario Canada L8L 2X2

www.phri.ca

Letter Concerning Dry Shipper and Specimen Non-Dangerous Status The Population Health Research Institute provides medical research colleagues world-wide with Dry Shippers for shipment of blood and urine specimens for analysis to the Central Laboratory located at the Hamilton Regional Lab Medicine Program, Canada. These specimens are collected from patients who are not known or expected to be infectious, and therefore are classified as “EXEMPT HUMAN SPECIMEN”, for air transportation purposes. This classification is in accordance with IATA Dangerous Goods Regulations; 48th Edition, January 2007, Section 3.6.2.2.3 and 3.6.2.2.6, and Note, page 106. It is important to note that these specimens are not classified as UN3373, and are not dangerous goods. Dry shippers are used to ensure specimens remain frozen throughout shipment. A “Dry Shipper” package consists of an outer container that is lined with a porous material. The container is filled with nitrogen that is absorbed into the lining and held the gas/vapour state. Liquid nitrogen not absorbed into the lining is poured out before shipment. The charged, completed package serves as refrigerated container for the shipment of specimens, and will keep specimens frozen for 10 or more days. It does not contain liquid nitrogen and therefore is exempt from IATA Hazardous Materials Regulations. Status is detailed as Special Provision/Exception A152, page 318 to Packing Instruction 202, for Div. 2.2. refrigerated liquefied, non-flammable gases, IATA Dangerous Goods Regulations, 48th Edition. The specimens in the Dry Shippers are collected internationally from patients for research on cardio-vascular disease and related issues. These specimens are without monetary value, and are irreplaceable. Thawed specimens cannot be used in our research and the loss of these specimens (by thawing) results negatively on our efforts to explore innovative and best treatments for patients. It is important that these specimens remain frozen. PHRI has had experience with the shipment of 600+ Dry Shippers since 1999. Please do not hesitate to contact us right away if you have questions or concerns about the Dry Shippers and the specimens. Your assistance and care of the specimens are very much appreciated. Rose Mayhew, CCRC, Research Co-ordinator Tel: 1-905-527-4322 ext. 44408 [email protected]

Director: Salim Yusuf D.Phil, FRCPC Associate Directors: Koon Teo MB,PhD,FRCPC, Sonia Anand MD,MSc,FRCPC

Khursh Ahmed MSc,PhD, Heather M. Arthur RN,PhD, Jackie Bosch MSc, BSc.OT, Sue Chrolavicius RN,BA(Econ), Stuart Connolly MD, FRCPC, Beena Cracknell, Susan Crook, Catherine Demers MD, MSc,FRCPC, PJ Devereaux MD, Ernest Fallen MD,FRCPC, Hertzel Gerstein MD,MS,MSc,FRCPC, Amram Ghafni PhD, Gordon Guyatt MD,FRCPC, Andre Lamy MD,MHSc, Eva Lonn MD,MSc,FRCPC,FACC, Robert McKelvie MD,PhD,FRCPC, Matthew McQueen MB,ChB,PhD,FRCPC, Shamir Mehta MD,FRCPC, Anthony Miele HBSc, Patty Montague MSc, Carlos A. Morillo MD,FRCPC, Katherine Morrison MD, FRCPC, Madhu Natarajan MD,FRCPC,FACC, Stephanie Ôunpuu PhD,RD, Janice Pogue MSc, Parminder Raina PhD, Barbara Ramos PhD, Arya Sharma MD, Steven Vacaroaia, Homer Yang MD,CCFP,FRCPC

http://www.phri.ca/

Appendix III

MATERIAL SAFETY DATA SHEET

PRODUCT INFORMATION PRODUCT: Liquid Nitrogen TRADE NAME: Liquid Nitrogen CHEMICAL NAME: Liquefied Nitrogen SYNONYMS: LIN; Nitrogen, Refrigerated Liquid FORMULA: Liquefied N2 CHEMICAL FAMILY: Cryogenic Liquid Inert MOLECULAR WEIGHT: 28.01 PRODUCT USE: Various PRODUCT IDENTIFICATION NUMBER: UN 1977 HAZARDOUS INGREDIENTS CHEMICAL ID CONCENTRATION CAS # LD(50) LC(50) Nitrogen 100% 7727-37-9 None None PHYSICAL DATA PHYSICAL STATE: Cryogenic liquid and gas APPEARANCE: Colorless (clear) liquid and gas ODOR: Odorless ODOR THRESHOLD: Not applicable SPECIFIC GRAVITY (H2O = 1): @ Boiling Point = 0.809 VAPOUR PRESSURE: Not applicable (gas) VAPOUR DENSITY (air = 1): 0.967 EVAPOURATION RATE: Varies with container insulation BOILING POINT: -195.8°C FREEZING POINT: -210.0°C pH: Not applicable GAS DENSITY: @ 15°C, 101.3 kPa = 1.185 kg/m³ COEFFICIENT OF WATER/OIL DISTRIBUTION: Not applicable FIRE OR EXPLOSION HAZARD CONDITIONS OF FLAMMABILITY: Nonflammable gas MEANS OF EXTINCTION: Nonflammable gas FLASHPOINT AND METHOD OF DETERMINATION:

Nonflammable gas

UPPER EXPLOSION LIMIT (% BY VOL):

Nonflammable gas

LOWER EXPLOSION LIMIT (% BY VOL):

Nonflammable gas

AUTO-IGNITION TEMPERATURE: Nonflammable gas FLAMMABILITY CLASSIFICATION: Nonflammable gas HAZARDOUS COMBUSTION PRODUCTS:

Nonflammable gas

EXPLOSION DATA: Nonflammable gas SENSITIVITY TO STATIC DISCHARGE:

None

REACTIVITY DATA CHEMICAL STABILITY: Stable

INCOMPATIBLE MATERIALS: None CONDITIONS OF REACTIVITY: Non-reactive at low and ambient temperature HAZARDOUS DECOMPOSITION PRODUCTS: None TOXICOLOGICAL PROPERTIES ROUTES OF ENTRY: SKIN CONTACT: Contact with the cryogenic liquid or cold piping containing the liquid can cause tissue freezing or frostbite on dermal contact or if splashed into the eyes. SKIN ABSORPTION: None EYE: See Skin Contact, above INHALATION: Effects of exposure to high concentrations so as to displace the oxygen in the air necessary for life are headaches, dizziness, labored breathing, eventual unconsciousness and death. INGESTION: None ACUTE OVER EXPOSURE EFFECTS: Liquid nitrogen is nontoxic but the liberation of a large amount in a confined area could displace the amount of oxygen in air necessary to support life. Frostbite effects are a change in color of the skin to gray or white possibly followed by blistering. CHRONIC OVER EXPOSURE EFFECTS: None EXPOSURE LIMITS: Nitrogen is defined as a simple asphyxiant. Oxygen levels should be maintained at greater than 18 molar percent at normal atmospheric pressure which is equivalent to a partial pressure of 135 mm Hg. (ACGIH, 1995-1996). IRRITANCY OF PRODUCT: See Skin Contact, above. SENSITIZATION TO MATERIAL: None CARCINOGENICITY, REPRODUCTIVE EFFECTS: None TERATOGENICITY, MUTAGENICITY: None TOXICOLOGICALLY SYNERGISTIC PRODUCTS: None

PREVENTIVE MEASURES PERSONAL PROTECTIVE EQUIPMENT: Loose fitting, insulated gloves. Safety goggles or glasses and face shield. safety shoes. SPECIFIC ENGINEERING CONTROLS: Liquid nitrogen cannot be handled in carbon or low steels. Eighteen-eight and 18-10 stainless steels are acceptable as are copper and its alloys, nickel and its alloys, brass, bronze, silicon alloys, Monel®, Inconel®, and beryllium. Also see CGA Safety Bulletin SB-2 and CGA pamphlets P-9, P-12, P-14. LEAK AND SPILL PROCEDURES: See Handling Procedures and Equipment, below. WASTE DISPOSAL: See Handling Procedures and Equipment, below. HANDLING PROCEDURES AND EQUIPMENT: Liquid nitrogen is delivered to a customer in stationary vacuum-jacketed vessels at the customer's location or in portable vacuum-jacketed "liquid cylinders". Stationary customer-site vessels should be operated in accordance with the manufacturer's and Air

Liquide Canada's instructions. Do not attempt to repair, adjust, or in any other way modify the operation of these vessels. If there is a malfunction or other type of operational problem with the vessel, contact the closest Air Liquide Canada location immediately. Liquid nitrogen cylinder should be used only in well-ventilated areas and in accordance with the manufacturer's and Air Liquide Canada's instructions. These cylinders must always be kept in an upright position. Specialized hand trucks are needed for their movement. A "fist in - first out" inventory system should be used with these cylinders. STORAGE REQUIREMENTS: See Handling Procedures and Equipment, above. TDG CLASSIFICATION: 2.2 WHMIS CLASSIFICATION: A SPECIAL SHIPPING INFORMATION: Always ship and handle liquid nitrogen cylinders in an upright position. FIRST AID MEASURES SPECIFIC FIRST AID PROCEDURES: PROMPT MEDICAL ATTENTION IS MANDATORY IN ALL CASES OF OVEREXPOSURE TO NITROGEN. RESCUE PERSONNEL SHOULD BE EQUIPPED WITH SELF-CONTAINED BREATHING APPARATUS. INHALATION: Conscious persons should be assisted to an uncontaminated area and inhale fresh air. Quick removal from the contaminated area is most important. Unconscious persons should be moved to an uncontaminated area, given mouth-to-mouth resuscitation and supplemental oxygen. Further treatment should be symptomatic and supportive. EYE CONTACT: See Skin Contact SKIN CONTACT: For dermal Contact or Frostbite: flush affected areas with lukewarm water. DO NOT USE HOT WATER. A physician should see the patient promptly if the cryogenic "burn" has resulted in blistering of the dermal surface of or deep tissue freezing. LAST REVISION DATE: 04/25/2002 THE INFORMATION, RECOMMENDATIONS AND DATA CONTAINED IN THIS DOCUMENT ARE INTENDED TO BE USED BY PROPERLY TRAINED AND QUALIFIED PERSONNEL ONLY AND AT THEIR SOLE RISKS AND DISCRETION. THE INFORMATION, RECOMMENDATIONS AND DATA HEREIN CONTAINED ARE DERIVED FROM SOURCES WHICH WE BELIEVE TO BE RELIABLE. HOWEVER, AIR LIQUIDE CANADA INC. MAKES NO REPRESENTATION AND GIVES NO WARRANTY OF ANY KIND WHATSOEVER WITH RESPECT TO THEIR ACCURACY OR COMPLETENESS AND ASSUMES NO LIABILITY FOR DAMAGES OR LOSS ARISING DIRECTLY OR INDIRECTLY FROM THEIR USE, WHETHER PROPER OR IMPROPER.

Appendix IV DATE OF EXPORT

DATE

EXPORT REFERENCES DRY SHIPPER

SHIPPER/EXPORTER Your Organization, Study Name and Site, Contact Person, Telephone #

CONSIGNEE: Population Health Research Inst. - STUDY NAME Deliver to Research Lab/Ramp Location 237 Barton Street East Hamilton, Ontario CANADA L8L 2X2 Tel. 1-905-527-4322 x 44326 or 44408

COUNTRY OF ORIGIN AND EXPORT YOUR COUNTRY

COUNTRY OF ULTIMATE DESTINATION CANADA

COURIER & INTERNATIONAL AIR WAYBILL NO.

# of Pkgs.

Type of packaging Full description of goods

QTY Unit of measure

Weight Total Value

_________

________

Dry Shipper in plastic shipping case 18x18x24”tall Not Dangerous, Not Restricted –Special Provision A152 see detail below. Sturdy cardboard box

Human blood and urine specimens

Not infectious, not restricted, for analysis only. Blood Spots on filter paper

EXEMPT HUMAN

SPECIMEN

____

____

2 ml

plastic vials

each

25 kg or 55 lb

each dry shipper & contents

0.5 kg or 1 lb each box of blood

spots

No commercial or customs value

2

Total Weight 25.5 kg or 56 lb

Total Invoice Value

$25 CDN

DRY SHIPPERS are refrigerated containers that DO NOT CONTAIN FREE LIQUID NITROGEN at time of shipment, DO NOT POSE A HAZARD IN TRANSPORTATION AND ARE NOT SUBJECT TO HAZARDOUS MATERIALS REGULATION. Status is detailed as Special Provision/Exception A152 to Packing Instruction 202, for Div. 2.2. refrigerated liquefied, non-flammable gases, IATA Dangerous Goods Regulations, 48th Edition January 2007. I DECLARE ALL THE INFORMATION CONTAINED IN THIS INVOICE TO BE TRUE AND CORRECT. Signature_____________________________________ _______________________________________________ Type/Print Name and Title here Date

Appendix V

Print Study Name & “DS”

Enter “FedEx Canada” here

PHRI will be billed directly for all customs and courier fees

Print: “EXEMPT HUMAN SPECIMEN, non infectious, not restricted. “

Enter your contact information here. Include study name, site, country and zip/postal code.

Complete with # of packages, weight and value shown on Commercial Invoice

sign and date

The 12-digit # AWB # used for tracking is located here. Please enter the # from your AWB on the Notice of Shipment Form.

Appendix VI Population Health Research Institute

237 Barton Street East, Hamilton, Ontario CANADA L8L 2X2 tel: +1-905 527-4322 x 44408/44326, fax: +1-905-527-9642

email: [email protected]

NOTICE OF SHIPMENT TO PHRI USING A DRY SHIPPER

DATE of Shipment: ________________________ Country: ________________ Shipper Contact Name:________________________________________________

(please print clearly) Tel:_____________________ Fax: ___________________

Email: _______________________________________________

Courier:___________ Air Waybill # /Tracking#____________________________ # of Dry Shippers: ______ Study Name(s) ______________________________________________________ Do you have any special concerns or information regarding the specimens in this shipment? Please specify:

Fax to +1-905-527-9642, scan and email to [email protected], or complete the webform at www.phri.ca/diagnosticspecimen.htm

Place 1 copy inside the “first” Dry Shipper Please do not ship between December 15 and December 31


http://www.phri.ca/diagnosticspecimen.htm

vapour shipper manual - phri · 2015-02-13 · • shipping documents for shipment to phri/canada...

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