verrucous carcinoma
DESCRIPTION
Verrucous carcinoma most often develops at the site of placement of tobacco quid. Verrucous carcinomas are slow-growing lesions. Although they invade adjacent structure, they do not trend to metastasize.VC is a slow growing progressive neoplasm with a clinical phase that last several years.VC most often occurs in the buccal mucosa, alveolar ridge and gingivae, tongue, floor of the mouth, and palate of elderly patient.The average age : male over the age 55 and 71 years for women.TRANSCRIPT
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Etiologymost VC appear to be related to the used of spit tobacco, either snuff or chewing tobacco.HPV found in 28% but unclear if relevant
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VC most often occurs in the buccal mucosa, alveolar ridge and gingivae, tongue, floor of the mouth, and palate of elderly patient.
The average age : male over the age 55 and 71 years for women.
Early lession appear as white patches , whereas more fully developed lession display a cauliflower-like papillary apperarance that spreads over a large area of the mucosa.
exophytic, warty or plaque-like; granular, red-white, hyperkeratotic; 1-10 cm; may invade adjacent soft tissue and bone
The margin are usually well defined and characteristically show a rim of slightly elevated mucosa where the tumor has pushed under the edge of the normal tissue and has undermined it slightly.
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Verrucous carcinoma most often develops at the site of placement of tobacco quid.
Verrucous carcinomas are slow-growing lesions. Although they invade adjacent structure, they do not trend to metastasize.
VC is a slow growing progressive neoplasm with a clinical phase that last several years.
Methatasis occurs rarely if ever. However, VC can transform into SCC and adopt a more aggressive behaviour.
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Extremely deceptive, many cases have been diagnosed originally as a simple papilloma or benign epitelial hyperplasia, because of the orderly n harmless appearance of the specimen.
Characteristically, cleftlike spaces lined by a thick layer of parakeratin extend from the surface deeply into the lesion.
The invasive downgrowth of the epitellium, and the cronic inflammatory cell just below invading epitellium.
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Verrucous carcinoma
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Condyloma Acuminatum Oral Squamous Papilloma Verruca Vulgaris Leukoplakia
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Surgical removal is the treatment of choice. Cryotherapy (freezing) also has a high cure rate for well-circumscribed lesions.
For large oral lession of VC may benefit from a combination of surgery and radiation therapy. Chemotherapy with bleomycin has also been used with some success to shrink the tumor before excision.
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Most patients have a good prognosis, as metastasis is rare. However, if SCC is identified within the verrucous carcinoma, the prognosis becomes much less favorable
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