VIETNAM: NATIONAL ACTION PLAN ON AMR AND

PROGRESS REPORT AT NIVR

DANG THI THANH SON-NIVR

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PRESENTATION OUTLINE

I. National Action Plan on AMU and AMR

II. Progress of the livestock component of the NAP at NIVR

III. Future activities

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1.

New Veterinary Law has

been effective since 01

July 2016.

4.

Decision No. 2625/QĐ-BNN-TY,

signed by MARD, 21/6/2017 on

National Action Plan for the Control

of Antimicrobial Use and

Antimicrobial Resistance in

livestock production and

aquaculture (2017-2020)

2.

5.

New Degree 39/2017/ND-

CP dated 4/4/2017 on

animal feeds with addition

of antibiotics which will be

totally eliminated in 2020.

MARD issued 11 Circulars

on disease control, AMU and

AMR; more than 20 official

letters to direct and enforce

controlling AMU, AMR

3.

6.

FAO supported Vietnam

to develop the NAP

since 2016

Developed and implemented the

national programme for strictly

control of the use of antibiotic

raw materials in veterinary

medicine production

I. NAP FOR THE CONTROL OF AMU AND AMR IN LIVESTOCK PRODUCTION AND AQUACULTURE (2017- 2020)

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Mitigate the risk of antibiotic resistance in public health through controlling the antibiotic

usage in livestock production and aquaculture in Vietnam.

3. Implement good treatment and husbandry practices in livestock production and

aquaculture

1. Review and enforce policy and governance related to AMR and AMU in livestock

production and aquaculture

4. Monitor AMR, AMU and antimicrobial residues in food and agriculture

2. Increase awareness of AMU and AMR among livestock and aquaculture

professionals, producers and consumers

5. Facilitate inter-sectoral collaboration in management of

the risk of AMR.

OBJECTIVES OF NAP

Overall objective:

Specific objective:

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MAJOR ACTIVITIES OF NAP

3. Enforce the regulations and technical guidelines in place;

1. Strengthen/consolidate the state management of AMU and AMR;

4. Increase awareness of AMU and the risks of AMR;

2. Improve the legal basis for AMU and AMR management;

5. Implement good treatment and husbandry practices in livestock

feed manufacturing and livestock production and aquaculture;

6. Monitor AMU, AMR and antibiotic residues;

7. Strengthen inter-sectoral collaboration in AMR management.

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Organizations involve NAP

1. DAH

2. DLP

3. DF

4. NAFIQUAQ

6. RIA1

7. SUB-DAHs

5. NIVR

9. LIVESTOCK/AQUACULTUL FARMS

8. VET.DRUG COMPANIES/INDUSTRIES/SHOPS

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Progress of the livestock component at NIVR(1)

Sponsors: FAO, DANIDA, VN GOVERMENT

3. Organized a number of workshops/meetings between government

agencies, companies, and other stakeholder-markers associations on

AMU and AMR to identify current problems, gaps and difficulties in the

control of AMU and AMR (Funded by FAO, DANIDA, CIRAD)

1. Member of Established National Committee for Controlling AMU and

AMR (lead by Deputy Prime Minister)

2. Review all regulations of AMU in livestock

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Progress of the livestock component at NIVR (2)

3. Overview Vet. drug system in different provinces

1. Baseline study on AMU and potential AMR in 7 provinces

(FAO and VIDAPIG)

2. Group discussion (VIDAPIG) and directly interview

Vet.drug company representatives

4. Database on AMR following international standard

(Denmark, Japan)

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Progress of the livestock component at NIVR(3)

1. During 2018-2019, conducted surveillance for AMR in pig,

pig-farmers, and chicken, in 7 provinces in Vietnam,

sponsored by FAO, DANIDA – Focusing AMR in enteric

bacteria (E. coli and Salmonella spp)

2. Studying on AMR (phenotype and improtant

resistance gens

detection- AmpC, mcr1-5, CTX,TEM, and SHV from farm-worker

and livestocks and antimicrobial residues

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Note: Ampicillin 10 µg (AMP); Gentamycin 10 µg (GEN); Trimethoprime 5 µg (TMP); Tetracyclin 30

µg (TET); Nalidixic acid 30 µg (NAL); Sulfonamides 300 µg (S3); Ciprofloxacin 5 µg (CIP);

Ceftriaxone 30 µg (CRO); Cefoxitin 30 µg (FOX); Amoxicillin-clavulanic 30 µg (AMC)

Progress of the livestock component at NIVR(1)

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ESBL producing E. coli detection

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Colistin resistant E. coli detection by MIC test

Type strains Sample Total

strains

(N)

MIC value (µg/ml) Breakpoint

(µg/ml)

Colistin resistant

E.coli n/N (%) 0.06 0.125 0.25 0.5 1 2 4 8 16

Isolated strains

from

cefotaxime

(2mg/l)

Pig manure 87 20 8 9 2 1 7 24 14 4

>2

42/87 (48,3%)

Farm-worker

excreta 58 15 7 17 2 5 2 8 2 10/58 (17,2%)

Isolated strains

from colistin

agar(4mg/l)

Pig manure 99 1 72 21 3 96/99 (97%)

Farm-worker

excreta 37 1 2 1 22 10 32/37 (86,5%)

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Colistin resistant gen detection in E.coli

Type strains Sample type

Total colistin

resistant E.coli

isolates

PCR done

No. of positive E.coli strains/ Total (%)

mcr1 mcr2 mcr3 mcr4 mcr5

Isolated strains

from colistin

agar(4mg/l)

Pig manure 96 78 73/78 (93,6%) 0 0 0 0

Farm-worker

excreta 32 26 23/26 (88,5%) 0 0 0 0

Isolated strains

from cefotaxime

(2mg/l)

Pig manure 42

Farm-worker

excreta 10

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AMR of Salmonella isolated from pork

Antibiotic

Hanoi Bacninh

n S (%) I (%) R (%) n S (%) I (%) R (%)

Ampicillin 30 10 (33,33) 0 20 (66,67) 23 9 (39,13) 0 14 (60,87)

Cefotaxime 30 29 (96,67) 1 (3,33) 0 23 23 (100) 0 0

Ceftazidime 30 29 (96,67) 1 (3,33) 0 23 23 (100) 0 0

Ciproflorxacin 30 13 (43,33) 13 (43,33) 4 (13,33) 23 6 (26,09) 16 (69,57) 1 (4,35)

Colistin sulfate 30 30 (100) 0 0 23 23 (100) 0 0

Chloramphenicol 30 11 (36,67) 0 19 (63,33) 23 9 (39,13) 0 14 (60,87)

Gentamicin 30 28 (93,33) 1 (3,33) 1 (3,33) 23 22 (95,65) 0 1 (4,35)

Nalidixic acid 30 27 (90) 2 (6,67) 1 (3,33) 23 22 (95,65) 1 (4,35) 0

Sulfornamide 30 7 (23,33) 0 23 (76,67) 23 6 (26,09) 0 17 (73,91)

Tetracycline 30 4 (13,33) 2 (6,67) 24 (80) 23 9 (39,13) 0 14 (60,87)

Trimethoprim 30 8 (26,67) 1 (3,33) 21 (70) 23 12 (52,17) 0 11 (47,83)

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Progress of the livestock component at NIVR(4)

3. Participated in national, regional and international

workshops/meetings on AMU and AMR to share and improve

1. Strengthening inter-sectoral collaboration in AMR management

2. Join sharing workshop “which multi-sectoral surveillance

system for ABR in VN?”, leading by CIRAD

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PLAN AND FUTURE ACTIVITIES SUPPORTING NAP FROM NIVR

3. Design intervention proposal on smart-use of antibiotic in collaboration

with international/national projects

1. Setting up database for AMR monitor program- VIETMAP

(VIDAPIG, FLEMMING FUND, ONECHICK, CIRAD)

2. Training/ high education on AMR

4. Communication/media on AMR

Thank you for your attention!