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Viral infection of the skin
Dr J Purcell
MBBS1
Friday 12th August 2011
Learning objectives
• To have an overview of the virological diversity of skin infections
• To be able to distinguish between localised viral skin infections and those with skin manifestations as a result of a systemic infection
• To know the aetiology, presentation, diagnosis, complications & treatment of common viral infections affecting the skin
Basic skin terminology
Flat
lesions
Raised
lesions
Fluid
filled
lesions
Smallest Macule Papule Vesicle
patch Nodule Blister
Largest plaque Bulla
viral rashes are frequently described as ‘maculopapular’.......................
Localised viral skin conditions
• Not a systemic illness
– signs confined to site of infection
• exceptionally may have associated Sx, eg primary
genital herpes infection
• Herpes simplex
– cold sores and genital herpes
• Herpes zoster
• Molluscum contagiosum
• Viral warts
• Orf
Herpes simplex (cold sores and
genital herpes)• HSV1 & HSV2
– ds DNA viruses
• Spread via saliva and genital secretions – usually infects mucous membranes but can infect minor skin
abrasions
• Basic lesion is intraepithelial vesicle
• Primary infection: herpetic gingivitis or genital herpes
• Latency in sensory ganglion
• Recurrences usually milder, closer grouping of smaller vesicles
• ComplicationsEye (dendritic ulcer), throat, eczema herpeticum, encephalitis,
meningitis (HSV2)
• Treatment: aciclovir, valaciclovir
Herpes simplex
Molluscum contagiosum
• Pox virus
• Common condition often seen in children
• Transmitted by contact
• Umbilicated flesh coloured papules – Koebnerisation seen
• May persist for months or years
• May be seen in association with immunosuppression– HIV
• Treatment: may not be necessary, minor surgery, cryotherapy, wart paints
Molluscum contagiosum
Viral warts
• Human papillomavirus (>120 types) dsDNA
• Spread by direct contact or autoinoculation into minor abrasions
• Various different types– Common, plantar, mosaic, plane, periungal, filiform,
oral, genital
• Genital warts usually types 6 and 11
• HPV 16,18, 31, 33, 35 associated with cervical cancer
from www.ncbi.nlm.nih.gov/books
Viral warts
treatment of warts
• In children, even without treatment, 50% of warts disappear within 6 months; 90% are gone in 2 years.
• More persistent in adults and imunosuppressed
• Treatment-chemical, cryotherapy
• Vaccination available against 16,18 and 6,11,16,18
• Many traditional remedies
Orf• Parapox virus
• ‘Contagious pustular
dermatitis’ in sheep
• Zoonosis
– sheep and goats
• Human lesions from
direct inoculation
– occurs in sheep farmers,
vets
• Incubation 5-6 days then
firm red, reddish- blue
lump which forms blister
or pustule
• Usually solitary, self
limiting
Common childhood viral infections
causing exanthems
• Measles
• Rubella
• Chicken pox
• Fifth disease
– ‘slapped cheek’, parvovirus B19
• Roseola
– ‘Exanthem subitum’, HHV 6/7
• Infectious mononucleosis/glandular fever
• Echovirus and adenovirus infections
Viral exanthems
•A rash with systemic symptoms, due to systemic
spread of virus
•The rash may or may not represent a site of virus
repication
•The rash may be immune mediated
Measles
• Paramxyovirus (enveloped ssRNA)
• Highly infectious, 90-100% susceptible contacts will show symptomatic disease
• Devastating disease in malnourished populations– estimated 1 million deaths per year worldwide in this setting
• Seasonality seen- dry season sees most cases
• Relies on cell mediated immunity for control
• Produces temporary defects in immunity for up to 1 month after illness
Measles timeline
day 0
invasion of local lymphatics
spread to lymphoid tissue throughout the body
enters blood next, then arrives at epithelial sites
eg respiratory tract, gastrointestinal,
skin
day 7-14 onset of symptoms
1. Prodrome
acute respiratory syndrome
conjunctivitis, fever
2. Kopliks spots 1 day prior
to rash, last for <48 hours
3. Skin rash, 3-4 days later
starts from face/head and
spreads to rest of body
Contagious
1 day prior to symptoms, until
approx day 4 of rash
Measles
Measles
• Complications– Diarrhoea exacerbating underlying
malnutrition
– Otitis media
– Pneumonia (either primary viral or secondary bacterial). The most common cause of death.
– Haemorrhagic rash
– Corneal disease leading to blindness esp if Vit A deficient- xerophthmia
– SSPE-v. rare
• Usually a clinical diagnosis
• IgM serology from blood or saliva for lab confirmation
• Prevention: – Vaccination. Live attenuated vaccine,
either single/MMR
Rubella (German measles)
• Togavirus, often asymptomatic
• Mild illness short lived illness
• Significance in pregnant women
• Incubation period 14-21 days, spread via nose/throat secretions
• Contagious 5 days pre symptoms to 3 days into symptoms
• Slight fever, sore throat, coryza, malaise
• Rash starts face, spreads to neck, trunk, extremities, may/may not be itchy
• Usually tender swollen occipital lymph nodes
• Sometimes arthralgia and arthritis
Rubella
post auricular lymphadenopathy
• Complications: Congenital Rubella Syndrome in 50% affected 1st trimester
• Prevention:– vaccination, live
attenuated vaccine (MMR)
Chicken pox- varicella zoster
virus• Largely childhood disease, more severe in adults
• Incubation period 10-21 days. Infectious 2 days pre illness - rash scabs
• Airborne spread or direct contact with vesicles
• May be prodrome, then itchy cropping rash of red papules starts on stomach, back and face then spreads, becomes vesicular, pustular then scabs
• Complications– Secondary bacterial infection, Viral pneumonia, disseminated
infection, CNS involvement, haemorrhagic lesions, scarring
– Congenital infection
• Diagnosis is clinical
• Consider aciclovir in >12y and immunocompromised. Passive immunisation with ZIG may modify disease
Chicken pox
Herpes zoster
• VZV remains latent in dorsal root ganglion
• Recurrence gives shingles in dermatome
– can be seen in children congenitally infected
in 2nd or 3rd trimester
• Usually pain, fever, headache precedes
blistering rash
• Complications
– post herpetic neuralgia
– ophthalmic shingles causing keratitis
• Diagnosis: clinical, IF, PCR of vesicle fluid
• Treatment: aciclovir as soon as possible
Herpes zoster
Other childhood exanthems
• Erythema infectiousum (fifth
disease/slapped cheek disease)
– Parvovirus B19
• Roseola (exanthem subitum)
– HHV6, HHV7
• Infectious mononucleosis (Glandular
fever)
– EBV
Other viral syndromes affecting
skin
• Hand, foot and mouth disease
– Coxsackie virus
• Smallpox, Cowpox, Monkey pox
• Arboviruses
– Chikungunya fever, Dengue and Dengue
haemorrhagic fever
• HIV
• Viral Haemorrhagic Fevers
HIV related viral disease
• Acute morbilliform rash due to HIV
• Viral infections– HSV, VZV, Molluscum,
HPV, oral hairy leukoplakia
• Malignancies – Eg Kaposi’s sarcoma
(coinfection with HHV8)
Suggested reading / viewing• Mims Medical Microbiology Goering, Dockrell et al
• 4th edn
– p368-385
• Medical Microbiology Greenwood et al
• 17th edn
– P662(general, v short!); P415-439 (herpesviruses); P440-445 (poxviruses); P446-453 (papillomaviruses); P501-502 (measles); P524-526 (rubella)
Review pictures in:
• An Atlas of African Dermatology by B Leppard
• Dermatology of Black Skin by A Basset, B Liautaud, B
Ndiaye
• http://web.squ.edu.om/med-
Lib/MED_CD/E_CDs/health%20development/html/client
s/skin/html/skin_06.htm#7