VITEK® MSMicrobiology Powered

by Mass Spectrometry

VITEK® MS

DELIVER RAPID, ACTIONABLE RESULTS TO CLINICIANS TO SUPPORT INFORMED TREATMENT DECISIONS.

TRULY INTEGRATED ID & AST SETUP Simple, step-by-step guided slide preparation for ID and connection with AST using the on-screen VITEK MS Prep Station.

SIMPLE SPOTTINGEasy sample preparation step of spotting organism onto slide and applying sample matrix for bacteria or matrix plus formic acid for yeasts.

LOAD SAMPLESVITEK MS carrier can be loaded with up to four prepared slides and introduced into the instrument. With 48 sample spots per target slide, 192 isolates can be tested per run.

LASERIonizes the sample.

RING ELECTRODEProtein “cloud” is released and accelerated by an electric charge.

TIME-OF-FLIGHTProteins travel up the flight tube before hitting the Detector. A long flight tube helps deliver high resolution spectra for increased accuracy.

DETECTORStructural proteins are detected to create a spectrum that represents the protein makeup of each sample.

SPECTRUMSpectrum from sample is carefully digitized using Advanced Spectra Classifier and Weighted Bin Matrix.

ROBUST DATABASEWith more than 15,000 strains and an average of 14 strains per species, the VITEK MS provides highly accurate results.

SAFE EXTRACTION PROCEDURE• No extractions required for routine bacteria and yeast identifications• Simple and reliable inactivation for Mycobacteria, Nocardia and molds4,5

• Studies show no viable organisms after performing inactivation steps6

• Post-inactivation processing steps may be performed in BSL2 lab

HIGH PERFORMANCE• 93.9% Total Combined Correct Identification Results• Mycobacteria – 99% accurate IDs with challenge strains7; 96.5% correct

single choice IDs from patient cultures• Molds – 94.0% accurate single choice IDs with challenge strains7

Rapid identification provides clinicians with valuable diagnostic information that helps them tailor antibiotic therapy. Rapid identifications by MALDI-TOF have been shown to reduce time to appropriate therapy in 28 to 44% of cases.1 They have also been shown to reduce both mortality2 and hospital length of stay.3

Mycobacteria Nocardia Molds Bacteria Yeast

FDA 510(k) cleared for 271 organisms — 1,046 total species in databaseOnly FDA cleared database for Mycobacteria, Nocardia and molds

242 new bacteria species and 55 new fungi species, including:

• 49 Mycobacterium species• 12 new Burkholderia• 5 new Legionella• 14 Nocardia species

• 11 new Corynebacterium• 5 new Yersinia• 79 molds• 14 new Staphylococcus

NEW! NEW! NEW!

• Rapid, safe and effective inactivation and extraction protocols offer excellent performance for identification of pathogenic microorganisms

• Easy workflow with convenient, prepackaged reagent kits

• In-lab solution to save time and costs compared to sending out tests or using other methods

VITEK MS provides identifications in minutes using an innovative mass spectrometry technology — Matrix Assisted Laser Desorption Ionization Time-of-Flight, or MALDI-TOF.

1. Tamma PD, Tan K, Nussenblatt VR, Turnbull AE, Carroll KC, Cosgrove SE. Can matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) enhance antimicrobial stewardship efforts in the acute care setting? Infect Control Hosp Epidemiol. 2013;34(9): 990 –995. 2. Patel TS, Kaakeh R, Nagel JL, Newton DW, Stevenson JG. Cost analysis of implementing matrix-assisted laser desorption ionization–time of flight mass spectrometry plus real-time antimicrobial stewardship intervention for bloodstream infections. J Clin Microbiol. 2016;55:60 –67. 3. Perez KK, Olsen RJ, Musick WL, et al. Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs. Arch Pathol Lab Med. 2013;137(9):1247–1254. 4. Dunne Jr. WM, Doing K, Miller E, et al. Rapid Inactivation of Mycobacterium and Nocardia Species before Identification Using Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry. J Clin Microbiol. 2014;52 (10) 3654-3659.

5. Totty H, Miller E, Moreno E, Dunne WM, Deol P. Comparison of Mechanical Disruption Techniques for Rapid Inactivation of Mycobacterium and Nocardia Species before Identification Using Matrix-Assisted Laser Desorption Ionization–Time of Flight (MALDI-TOF) Mass Spectrometry. J Clin Microbiol. 2016;54 (10) 2626-2627.6. Dunne WMJ, Doing K, Miller E, et al. Rapid Inactivation of Mycobacterium and Nocardia species before identification using Matrix-Assisted Laser Desorption Ionization-Time of Flight mass spectrometry. J Clin Microbiol.. 2014;52:3654-3659. 7. U.S. Food & Drug Administration. 510(k) substantial equivalence determination decision summary. https://www.accessdata.fda.gov/cdrh_docs/reviews/K162950.pdf. Accessed September 20, 2018.8. Altun O, Almuhayawi M, Lüthje P, Taha R, Ullberg M, Özenci V. Controlled evaluation of the new BACT/ALERT VIRTUO blood culture system for detection and time to detection of bacteria and yeasts. J Clin Microbiol. 2016;54(4):1148-1151.

References

ANTIMICROBIAL STEWARDSHIP

EMPOWERED BY RAPID DIAGNOSTICSTM

VITEK® MSIdentification from pure culture within minutes

PCT-Guided Antibiotic TherapyBACT/ALERT® VIRTUO®

Up to 4 hours faster time to detection for bloodstream infections8

VITEK® 2Antimicrobial susceptibilities in 8 to 10 hours

C / T

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1.51.0.75.50.38.25.19

.125.094.064.047.032.023.016

ETEST®

MIC Breakpoints – Reliable and valuable manual AST solution to guide therapy and manage treatment

Identify infection from a positive blood culture in about an hour

BIOFIRE® FILMARRAY®

VIDAS® B•R•A•H•M•S PCT™

VITEK® MS

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bioMérieux, Inc. • 100 Rodolphe Street • Durham, NC 27712 • USA • Tel: (800) 682 2666 • Fax: (800) 968 9494 www.biomerieux-usa.com

To place an order, visit

www.biomerieuxDIRECT.com

Rapid Automated Pathogen Identification in Minutes, Supporting & Advancing Antimicrobial Stewardship Programs