vol. 33 the journal of biological chemistry · biological chemistry ... mobile loop of porcine...
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Vol. 268, No. 33 The Journal of November 25, 1993
Biological Chemistry Copyright 0 1993 by the American Society for Biochemistry and Molecular Biology, Inc.
428 East Preston St., Baltimore, MD 21202 U.S.A.
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CONTENTS*
COMMUNICATIONS
Optimization of an anti-HIV hairpin ribozyme by in vitro selection. Simpson Joseph and John M. Burke
Specific interaction with rhodopsin is dependent on the y subunit type in a G protein. Oleg Kisselev and Narasim- han Gautam
Identification of bovine glutamate dehydrogenase as an RNA-binding protein. Thomas Preiss, Andrew G. Hall, and Robert N . Lightowlers
A small C-terminal region of the Escherichia coli MalT protein contains the DNA-binding domain. Dominique Vidal-Ingigliardi, Euelyne Richet, Oliuier Danot, and Olivier Raibaud
binding of ADP-ribosylation factor ARFl to phospho- Myristoylation is not required for GTP-dependent
lipids. Michel Franco, Pierre Chardin, Marc Chabre, and Sonia Paris
ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. Naokazu Kumagai, Narito Morii, Kazuko Fujisawa, Yasuo Nemoto, and Shuh Narumiya
Expression cloning of type 2 angiotensin I1 receptor reveals a unique class of seven-transmembrane recep-
Horiuchi, Hiroyuki Sasamura, Richard E. Pratt, and Victor J. tors. Masashi Mukoyama, Masatoshi Nakajima, Masatsugu
Dzau
Molecular cloning of a novel angiotensin I1 receptor isoform involved in phosphotyrosine phosphatase in- hibition. Yoshikazu Kambayashi, Smriti Bardhan, Kyoko
and Tadashi Inagami Takahashi, Satoshi Tsuzuki, Hiroshi Inui, Takao Hamakubo,
In vivo control of redox potential during protein folding catalyzed by bacterial protein disulfide-isomerase (DsbA). Martina Wunderlich and Rudi Glockhuber
GK* and brain G8, activate muscarinic K+ channel
Jahangir, Yukio Hosoya, A t s w h i Inanobe, Toshiaki Katada, through the same mechanism. Mitsuhiko Yamada, Arshad
and Yoshihisa Kurachi
of chloramphenicol acetyltransferase. J o h n Robben, J a n Carboxyl terminus is essential for intracellular folding
Van der Schueren. and Guido Volckaert
ARTICLES
Phospholipase C activation during elicitation of the oxidative burst in cultured plant cells. Laurent Legendre, Yir G. Yueh, Richard Crain, Nathan Haddock, Peter F. Hein- stein, and Philip S. Low
Sequence of the sodium ion pump methylmalonyl-CoA
and Peter Dimroth decarboxylase from Veillonella parvula. Jon B. Huder
Effect of mutations at active site residues on the activ-
active site-directed irreversible inhibitors. Catherine S. ity of ornithine decarboxylase and its inhibition by
Coleman, Bruce A. Stanley, and Anthony E. Pegg
Cloning of a gene (PSDl) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by com-
J . Clancey, Shao-Chun Chang, and William Dowhan plementation of an Escherichia coli mutant. Constance
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24655
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24669
24677
24683
24692
Eicar (5-ethynyl-1-~-~-ribofuranosylimidazole-4-car- boxamide). A novel potent inhibitor of inosinate dehy- drogenase activity and guanylate biosynthesis. Jan Bal- zarini, Anna Karlsson, Liya Wang, Christina Bohman, Kvetos-
Aerschot, Piet Herdewijn, and Erik De Clercq lava Horska, Ivan Votruba, Arnold Fridland, Arthur Van
Site-directed mutagenesis of rabbit muscle phospho- fructokinase cDNA. Mutations a t glutamine 200 affect
Zhu, Malcolm Byres , Je f f r ey W. Nelson, and Simon H. Chang the allosteric properties of the enzyme. Jauyi Li, Xiaomao
Kinetic mechanism of the DNA-dependent DNA polym- erase activity of human immunodeficiency virus re- verse transcriptase. Jen-Chih Hsieh, Shawn Zinnen, and Paul Modrich
Purification and sequence of rat extracellular super- oxide dismutase B secreted by CS glioma. Jean Willems, A n Zwijsen, Herman Slegers, Stefan Nicolac, Jayaram Betta- dapura, Jos Raymackers, and Thierry Scarcez
Probing the reactivity of the GTP- and GDP-bound conformations of elongation factor Tu in complex with the antibiotic GE2270 A. Pieter H. Anborgh and Andrea Parmeggiani
Biochemical comparisons of the Saccharomyces cere-
Cdc42 GTPase-activating protein domain. Y i Zheng, uisiae Bern2 and Bema proteins. Delineation of a limit
Matthew J . Hart, Katsuhiro Shinjo, Tony Evans, Alan Bender, and Richard A . Cerione
Ca2+-induced folding and aggregation of skeletal mus- cle sarcoplasmic reticulum calsequestrin. The involve-
Keith Dunker, Carla R. Wesson, and William R. Trumble ment of the trifluoperazine-binding site. Zhaoping He, A.
Electron transfer process in milk xanthine dehydro- genase as studied by pulse radiolysis. Kazuo Kobayashi, Miyako Miki, Ken Okamoto, and Takeshi Nishino
Phosphorylation and active ATP hydrolysis are not required for SV40 T antigen hexamer formation. Inga Reynisdottir, Heather E. Lorimer, Paula N . Friedman, Edith H. Wang, and Carol Priues
VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the ex-
Alejandro Aruffo tracellular matrix ligand fibronectin. Po-Ying Chan and
Fluid membranes with acidic domains activate DnaA, the initiator protein of replication in Escherichia coli. Celina E. Castuma, Elliott Crooke, and Arthur Kornberg
CAMP regulates G-protein ai.2 subunit gene transcrip- tion in polarized LLC-PKI cells by induction of a CCAAT box nuclear binding factor. T. Bernard Kinane, Cheng Shang, Jonathan D. Finder, and Louis Ercolani
Directional regulatory activity of cis-acting elements in the bidirectional al(IV) and a2(1V) collagen gene promoter. Pirkko Heikkila, Raija Soininen, and Karl Trygguason
Characterization of mutations in the b subunit of FIFO ATP synthase in Escherichia coli. Kimberly A. Mc-
and Brian D. Cain Cormick, Gabriele Deckers-Hebestreit, Karlheinz Altendorf,
Inhibition of SDC25 C-domain-induced guanine-nu- cleotide exchange by guanine ring binding domain mu-
Poullet, and Andrea Parmeggiani tants of v-H-ras. Yu- Wen Hwang, Jie-Ming Zhong, Patrick
* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1993) J. Bid. Chem. 268, 14543-14551, and reprints may be obtained from the editorial office.
iii
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How do "Znl Cyss" proteins distinguish between similar
binding specificity of the Gal4 protein in vitro and in upstream activation sites? Comparison of the DNA-
vivo. Sanjay Vashee, HLlagiang Xu, Stephen A. Johnston, and Thomas Kodadek
rotoxin ShI. Gauin R. Wilcox, Rasmus H. Fogh, and Raymond Refined structure in solution of the sea anemone neu-
S. Norton
Isolation and expression of a cDNA encoding a male- specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene. Kiyoshi Nagata, Shogo Ozawa, Masaaki Miyata, Miki Shimada, Da- Wei Gong, Yasushi Yamazoe, and Ryuichi Kat0
Purification of an acyl-CoA hydrolase from rat intes- tinal microsomes. A candidate acyl-enzyme intermedi- ate in glycerolipid acylation. Richard Lehner and Arnis Kuksis
Interaction of bacterial luciferase with aldehyde sub- strates and inhibitors. Wilson A. Francisco, Husam M. Abu-Soud, Thomas 0. Baldwin, and Frank M. Rawhel
Behavior of Cys-707 (SH1) in myosin associated with ATP hydrolysis revealed with a fluorescent probe linked directly to the sulfur atom. Toshiaki Hiratsuka
Dissociation of platelet-activating factor production and arachidonate release by the endomembrane CaZ+- ATPase inhibitor thapsigargin. Evidence for the in- volvement of a Ca2+-dependent route of priming in the production of lipid mediators by human polymorpho- nuclear leukocytes. Carmen Garcia Rodriguez, Mayte Mon- tero, Jauier Aluarez, Jauier Garcia-Sancho, and Mariano San- chez Crespo
Functional roles of valine 37 and glycine 38 in the mobile loop of porcine cytosolic aspartate aminotrans- ferase. Qian- Wen Pan, Sumio Tanase, Yuhji Fukumoto, Fuji0 Nagashima, Sangkee Rhee, Paul H. Rogers, Arthur Arnone, and Yoshimasa Morino
Multiubiquitin chains linked through lysine 4 8 are abundant in vivo and are competent intermediates in the ubiquitin proteolytic pathway. Steven uan Nocker and Richard D. Vierstra
The anti Z-DNA reactivity of Z-DNA forming se- quences is affected by platinum antitumor drugs. Jose Manuel Perez-Martin, Jose Maria Requena, Dan Craciunescu, Manuel Carlos Ldpez, and Carlos Alonso
ATP and A1 adenosine receptor agonists mobilize intra- cellular calcium and activate K+ and C1- currents in normal and cystic fibrosis airway epithelial cells. Mich- ela Rugolo, Teresa Mastrocola, Cloudia Whdrle, Andrea Rasola, Dieter C. Gruenert, Grouanni Romeo, and Luis J. V. Galietta
Purification and characterization of an enzyme in- volved in oxidative carbon-carbon bond cleavage re- actions in the methionine salvage pathway of Klebsiella pneumoniae. Robert W. Myers, Jonathan W. Wray, Susan Fish, and Robert H. Abeles
enzyme E-1 from the methionine salvage pathway of Appendix. Cloning and sequence of the gene encoding
Klebsiella oxytoca. Ramaswamy Balokrishnan, Michael Frohlich, Peter T. Rahaim, Keith Backman, and R. Rogers Yocum
Reversible association of a 97-kDa protein complex found at the tips of ciliary microtubules with in vitro assembled microtubules. Wen Wang, Kathy Suprenant, and William L. Dentler
binding domain of the orphan nuclear receptor NGFI- The phosphorylation and DNA binding of the DNA-
Milbrandt, and Gordon Guroff B. Yoko Hirata, Kazutoshi Kiuchi, Hao-Chia Chen, Jeffrey
The Schitosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein. Dennis Dooijes, Marc van de Wetering, &on Knippels, and Hans Cleuers
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Analysis of lipopolysaccharide binding by CD14. The0
Lee, R. J. Uleuitch, and Peter S. Tobias N. Kirkland, Fred Finley, Didier Leturcq, Ann Moriarty, J.-D.
Alterations in the electron transfer chain in mutant strains of Escherichia coli lacking phosphatidyletha- nolamine. Eugenia I. Mileykovskaya and William Dowhan
Lipophilic 1,l-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol low- ering agents in vivo. Carl P. Ciosek, Jr., David R. Magnin, Thomas W. Harrity, Janette V. H. Logan, John K. Dickson,, Jr., Eric M. Gordon, Kelly A. Hamilton, Kern G. Jolibois, &art K. Kunselman, R. Michael Lawrence, Kasim A. Mookhttar, Lois C. Rich, Dorothy A . Slusarchyk, Richard B. Sulsky, and Scott A . Btller
Alteration of vitronectin. Characterization of changes induced by treatment with urea. Steven V. Bittorf, Eliot C. Williams, and Deane F. Masher
Cytotoxicity of folate-Pseudomonas exotoxin conju-
domain. Christopher P. Leamon, Ira Pastan, and Philip S. gates toward tumor cells. Contribution of translocation
Low
Processivity of mitochondrial DNA polymerase from Drosophila embryos. Effects of reaction conditions and enzyme purity. Andrea J . Wi l l iam, Catherine M. Wernette, and Laurie S. Kaguni
Characterization of wheat germ protein synthesis ini- tiation factor eIF-4C and comparison of eIF-4C. from wheat germ and rabbit reticulocytes. Richard T. T m m e r , Sandra R. Lax, Diane L. Hughes, William C. Merrick, Joanne M. Ravel, and Karen S. Browning
Evidence for kinetically distinct forms of pp60""" with
J. A. Budde different Km values for their protein substrate. Raymond
The interaction of N-ethyl retinamide with plasma ret- inol-binding protein (RBP) and the crystal structure of
Zanotti, Giorgio Malpeli, and Rodolfo Berni the retinoid-RBP complex at 1.9-A resolution. Giuseppe
A novel receptor tyrosine phosphatase-o that is highly expressed in the nervous system. Hai Yan, Albert Gross- man, Hong Wang, Peter D'Eustachio, Keuin Mossie, Jose M . Musacchio, Olli Siluennoinen, and Joseph Schlessinger
by a furin-directed al-antitrypsin variant. Eric D. A n - Inhibition of HIV-1 gpl6O-dependent membrane fusion
derson, Laurel Thomas, Joel S. Hayflick, and Gary Thomas
Three clustered S p l sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat. Yues R. Boisclair, Alexandra L. Brown, Stefan0 Casoln, and Matthew M. Rechler
Characterization of the cell adhesion molecule gp24 in Dictyostelium discoideum. Mediation of cell-cell adhe- sion via a Caz+-dependent mechanism. Simuran Kaur Brar and Chi-Hung Siu
Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells. Fu-Sheng Shen, Nabil G. Seidah, and Iris Lindberg
Diversity of intermediate filament structure. Evidence that the alignment of coiled-coil molecules in vimentin is different from that in keratin intermediate filaments. Peter M. Steinert, Lyuben N. Marekou, and David A . D. Parry
Essentiality of the three carboxyl-terminal amino acids of the plasmid RK2 replication initiation protein TrfA for DNA binding and replication activity in Gram- negative bacteria. Joan Lin Cereghino and Donald R. Helinski
Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme Class. YOO- WU Zheng, Monica Bey, Hong Liu, and Michael R. Felder
428 East Preston Street, Baltimore, MD 21202, U.S.A. Volume 269 for 1994: Institutions: United States, $790; Foreign, $980. Students/PostdoctoraI The Journal of Biological Chemistry (ISSN 0021-9258) is published weekly by the American Society for Biochemistry and Molecular Biology, Inc.,
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Effects of integration and replication on transcription of the HIV-1 long terminal repeat. Kuan-Teh Jeang, Ben Berkhout, and Bora Dropulic
y-subunit. Tissue specificity produced by alternative Gene structure of human mitochondrial ATP synthase
and Yasuo Kagawa RNA splicing. Chie Matsuda, Hitoshi Endo, Shigeo Ohta,
of nitric oxide synthase in cultured vascular smooth Cyclic AMP-elevating agents induce an inducible type
muscle cells. Synergism with the induction elicited by inflammatory cytokines. Masanobu Koide, Yasuhiro Ka- wahara, Ichiro Nakayama, Terutaka Tsuda, and Mitsuhiro Yokoyama
Post-translational processing of proopiomelanocortin
duced by a POMC-Simian virus 40 large T antigen (POMC) in mouse pituitary melanotroph tumors in-
transgene. Malcolm J. Low, Bin Liu, Gary D. Hammer, Marcel0 Rubinstein, and Richard G. Allen
Dynamic aspects of DNA/protein interactions in the transcriptional initiation complex and the hormone- responsive domains of the phosphoenolpyruvate car- boxykinase promoter in vivo. Steven Faber, Richard M. O’Brien, Enyu Imai, Daryl K. Granner, and Roger Chalkley
transferase active site lysine. Edward G. Niles and Linda Identification of the vaccinia virus mRNA guanyl-
Christen
Impaired biosynthesis of phosphatidylcholine causes a
particles in the Golgi but not in the endoplasmic retic- decrease in the number of very low density lipoprotein
ulum of rat liver. Henkjan J. Verkade, Darren G. Fast, Antonio E. Rusiriol, Douglas G. Scraba, and Dennis E. Vance
An activation-associated ganglioside in rat thymocytes. Keiko Nohara, Tomoharu Sano, and Fuji0 Shiraishi
Palmitoylation is required for signaling functions and
gaertner, David H. Chu, Paul Wilson, Mark J. Levis, and membrane attachment of G and G a . Philip B. Wede-
Henry R. Bourne
Endotoxin induces rapid protein tyrosine phosphoryl- ation in 70Z/3 cells expressing CD14. Jiahuai Hun, Jiing-Dwan Lee, Peter S. Tobias, and Richard J . Uleuitch
Binding of collagen XIV with the dermatan sulfate side chain of decorin. Bernard Font, Elisabeth Aubert-Foucher, Denise Goldschmidt, Denise Eichenberger, and Michel van der Rest
Role of glucokinase and glucose-6-phosphatase in the
by insulin. Nir Barzilai and Lucian0 Rossetti acute and chronic regulation of hepatic glucose fluxes
Enhanced activation of the human histone H2B pro- moter by an Oct-1 variant generated by alternative splicing. Gokul Das and Winship Herr
RNA polymerases IIA and I10 have distinct roles dur- ing transcription from the TATA-less murine dihydro- folate reductase promoter. Mona E. Kang and Michael E. Dahmus
Cloning of a membrane-associated protein which mod-
transporter. Maike Veyhl, Jorg Spangenberg, Bernd Piischel, ifies activity and properties of the Na+-D-glucose co-
Robert Poppe, Carmela Dekel, Giinter Fritzsch, Winfried Haase, and Hermann Koepsell
Identification of the major phosphorylation domain of murine rndrlb P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites. George A. Orr, Edward K.-H. Hun, Paul C. Browne, Edward Nieues, Brigid M. O’Connor, Chia-Ping Huang Yang, and Susan Band Horwitz
Isolation of a protein activator of the clathrin-coated vesicle proton pump. X&-Song Xie, Bill P. Crider, and Dennis K. Stone
Expression of the complement classical pathway by
expression by nerve cells. Philippe Casque, Alexander human glioma in culture. A model for complement
Ischenko, Jocelyne Legoedec, Claire Mauger, Marie-Thirese Schouft, and Marc Fontaine
Purification and characterization of a mitogen-acti-
pus eggs. Boris Sarceuic, Eleanor Erikson, and James L. vated protein kinase tyrosine phosphatase from Xeno-
Muller
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25124
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Characterization of the nucleational core complex re- sponsible for mineral induction by growth plate carti- lage matrix vesicles. Licia N. Y. Wu, Takayuki Yoshimori,
Ishikawa, and Roy E. Wuthier Brian R. Genge, Glenn R. Sauer, Thorsten Kirsch, Yoshinori
Angiotensin I1 stimulates the synthesis of angiotensin- ogen in hepatocytes by inhibiting adenylylcyclase ac-
Klett, Ruiner Nobiling, Peter Gierschik, and Eberhard tivity and stabilizing angiotensinogen mRNA. Christoph
Hackenthal
The agrin receptor. Localization in the postsynaptic
the acetylcholine receptor. Jianyi Ma, Mary A. Nastuk, membrane, interaction with agrin, and relationship to
Beth A. McKechnie, and Justin R. Fallon
Chloroplast-encoded protein as a subunit of acetyl-coA carboxylase in pea plant. Yukiko Sasaki, Kazuhiko Haka- mada, Yukiko Suama, Yukio Nagana, Iwao Furusawa, and Ryuichi Matsuno
Identification of a secondary FcyRI binding site within
anne Chappel, David E. Isenman, R. Oomen, Yuan Yuan Xu, a genetically engineered human IgG antibody. M. Suz-
and Michel H. Klein
Raf perinuclear translocation via a protein kinase C- 1,25-Dihydroxyvitamin Ds activates Raf kinase and
dependent pathway. Trevor W. Lissoos, David W. A. Beno, and Bernard H. Davis
Independent regulation of two cytoplasmic processing stages of the intermediate filament-associated protein
A. Resing, Nadia Al-Alawi, Cheryl Blomquist, Phil Fleckman, filaggrin and role of Caz+ in the second stage. Katheryn
and Beverly A. Dale
Phosphorylation of synthetic peptides containing Tyr- Met-X-Met motifs by nonreceptor tyrosine kinases in
Duane A . Hinds, Allan R. Coldberg, and W . Todd Miller vitro. Pilar Garcia, Steven E. Shoelson, Shaji T. George,
Molecular cloning of two abundant protein tyrosine kinases in Torpedo electric organ that associate with the acetylcholine receptor. Sheridan L. Swope and Richard L. Huganir
substitutions for glycine in the a 2 (I) collagen chain. A Two additional cases of osteogenesis imperfecta with
type. Qin Wang, Bonnie M. Orrison, and Joan C. Marini regional model relating mutation location with pheno-
Movement of apolipoprotein B into the lumen of micro- somes from hepatocytes is disrupted in membranes en- riched in phosphatidylmonomethylethanolamine. Anto- nio E. Rusiriol, Edmond Y. W. Chan, and Jean E. Vance
Characterization of the lectin from the bulbs of Eran-
synthesis. M. Arun Kumar, David E. Timm, Kenneth E. this hyernalis (winter aconite) as an inhibitor of protein
Neet, Whyte G. Owen, Willy J . Peumans, and A. Gururaj Rao
Purification of a 110-kDa phosphoinositide phospholi- pase C that is activated by G-protein By-subunits. Jon- athan L. Blank, Karen Shaw, Annette H. Ross, and John H. Exton
Function of the GrpE heat shock protein in bidirec- tional unwinding and replication from the origin of phage X. Claire Wyman, Christos Vasilikiotis, Debbie Ang, Costa Georgopoulos, and Harrison Echols
Osteogenic protein-1 regulates L1 and neural cell adhe- sion molecule gene expression in neural cells. George Perides, Guang Hu, David C. Rueger, and Michael E. Charness
Loading dependence of inositol 1,4,5-trisphosphate-in- duced Ca2+ release in the clonal cell line A7r5. Impli- cations for the mechanism of quantal Ca2+ release. J a n B. Parys, Ludwig Missiaen, Humbert De Smedt, and Rik Casteels
Calmodulin-cardiac troponin C chimera. Effects of do- main exchange on calcium binding and enzyme activa- tion. Samuel E. George, Zenghua Su, Daju Fan, and Anthony R. Means
The role of nucleotides conserved in eukaryotic initia-
Harold J . Drabkin, Bernhard Helk, and Uttam L. RajBhandary tor methionine tRNAs in initiation of protein synthesis.
ity detection of protein-DNA interactions. Application Stable fluorescent dye-DNA complexes in high sensitiv-
to heat shock transcription factor. Hays S. Rye, Becky L. Drees, Hillary C. M. Nelson, and Alexander N . Glazer
vii
25239 Spatial resolution of fodrin proteolysis in postischemic brain. Takaomi C. Saido, Masayuki Yokota, Shunsuke Nagao, Ikuya Yarnaura, Eiichi Tani, Takahide Tsuchiya, Koichi Su- zuki, and Seiichi Kawashirna
25244 I n vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myo- sin light chain-2 gene is independent of heart tube formation. Wanda C. Miller-Hance, Monique LaCorbiere, Stephen J. Fuller, Sylvia M. Evans, Gary Lyons, Christel Schmidt, Jeffrey Robbins, and Kenneth R. Chien
25253 Characterization and chromosomal mapping of the hu-
Masakazu Hirata, Akrra Kakizuka, Toshihrko Eki, Kazuo man thromboxane A. receptor gene. Rolf M. Niising,
Ozawa, and Shuh Narumiya
25260 Molecular requirements for the cell-surface expression of multisubunit ion-transporting ATPases. Identifica- tion of protein domains that participate in Na,K-ATP- ase and H,K-ATPase subunit assembly. Vol. 268 (1993) 14342-14347. Cara J. Gottardr and Mrchael J. Caplan
xiii Cumulative author index. Numbers 1 through 33.
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Vol. 268, No. 33 The Journal of Biological Chemistry November 25, 1993
CONTENTS Arranged by
CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS
24832 Lipophilic 1,l-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol low- ering agents in vivo. Carl P. Ciosek, Jr., David R. Magnin,
Jr., Eric M. Gordon, Kelly A . Hamilton, Kern G. Jolibois, Lori Thomas W. Harrity, Janette V. H. Logan, John K. Dickson,
K. Kunselman, R. Michael Lawrence, Kasim A. Mookhtiar, Lois C. Rich, Dorothy A . Slusarchyk, Richard B. Sulsky, and Scott A. Biller
24997 An activation-associated ganglioside in rat thymocytes. Keiko Nohara, Tomoharu Sano, and Fuji0 Shiraishi
25118 Chloroplast-encoded protein as a subunit of acetyl-coA carboxylase in pea plant. Yukiko Sasaki, Kazuhiko Haka- mada, Yukiko Suama, Yukio Nagano, Iwao Furusawa, and Ryuichi Matsuno
CELL BIOLOGY AND METABOLISM 024519 Specific interaction with rhodopsin is dependent on the
y subunit type in a G protein. Oleg Kisseleu and Narasim- han Gautam
024523 Identification of bovine glutamate dehydrogenase as an RNA-binding protein. Thomas Preiss, Andrew G. Hall, and Robert N . Lightowlers
-24531 Myristoylation is not required for GTP-dependent binding of ADP-ribosylation factor ARFl to phospho-
Sonia Paris lipids. Michel Franco, Pierre Chardin, Marc Chabre, and
024535 ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. Naokazu Kumagai, Narito Morii, Kazuko Fujisawa, Yasuo Nemoto, and Shuh Narumiya
-24543 Molecular cloning of a novel angiotensin I1 receptor
hibition. Yoshikazu Kambayashi, Smriti Bardhan, Kyoko isoform involved in phosphotyrosine phosphatase in-
Takahashi, Satoshi Tsuzuki, Hiroshi Inui, Takao Hamakubo, and Tadashi Inagami
-24551 GK* and brain Got activate muscarinic K+ channel
Jahangir, Yukio Hosoya, Atsushi Inanobe, Toshiaki Katada, through the same mechanism. Mitsuhiko Yamada, Arshad
and Yoshihlsa Kurachi
24559 Phospholipase C activation during elicitation of the oxidative burst in cultured plant cells. Laurent Legendye, Yir G. Yueh, Richard Crain, Nathan Haddock, Peter F. Hern- stein, and Philip S. Low
24591 Eicar (5-ethynyl-l-~-~-ribofuranosylimidazole-4-car- boxamide). A novel potent inhibitor of inosinate dehy- drogenase activity and guanylate biosynthesis. J a n Bal- zarini, Anna Karlsson, Liya Wang, Christina Bohman, Kuetos-
Aerschot, Piet Herdewijn, and Erik De Clercq lava Horska, Ivan Votruba, Arnold Fridland, Arthur Van
24655 VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the ex- tracellular matrix ligand fibronectin. Po- Yrng Chon and Alejandro Aruffo
24692 Inhibition of SDC25 C-domain-induced guanine-nu- cleotide exchange by guanine ring binding domain mu- tants of v-H-ras. Yu- Wen Hwang, Jie-Ming Zhong, Patrick Poullet, and Andrea Parmeggiani
24751 Dissociation of platelet-activating factor production and arachidonate release by the endomembrane CaZ+- ATPase inhibitor thapsigargin. Evidence for the in- volvement of a Ca2+-dependent route of priming in the production of lipid mediators by human polymorpho- nuclear leukocytes. Carmen Garcia Rodriguez, Mayte Mon- tero, Javier Aluarez, Jauier Garcia-Sancho, and Mariano San- chez Crespo
Subject Categories
24766 Multiubiquitin chains linked through lysine 48 are abundant in vivo and are competent intermediates in
Richard D. Vierstra the ubiquitin proteolytic pathway. Steven van Nocker and
24796 Reversible association of a 97-kDa protein complex found at the tips of ciliary microtubules with in vitro assembled microtubules. Wen Wang, Kathy Suprenant, and William L. Dentler
24808 The phosphorylation and DNA binding of the DNA- binding domain of the orphan nuclear receptor NGFI- B. Yoko Hirata, Kazutoshi Kiuchi, Hao-Chia Chen, Jeffrey Milbrandt, and Gordon Guroff
24818 Analysis of lipopolysaccharide binding by CD14. The0 N . Kirkland, Fred Finley, Didier Leturcq, A n n Moriarty, J.-D. Lee, R. J . Uleuitch, and Peter S. Tobias
24847 Cytotoxicity of folate-Pseudomonas exotoxin conju- gates toward tumor cells. Contribution of translocation domain. Christopher P. Leamon, Ira Pastan, and Philip S. Low
24880 A novel receptor tyrosine phosphatase-o that is highly expressed in the nervous system. Hai Yan, Albert Gross- man, Hong Wang, Peter D’Eustachio, Kevin Mossie, Jose M. Musacchio, Olli Siluennoinen, and Joseph Schlessinger
24887 Inhibition of HIV-1 gpl6O-dependent membrane fusion by a furin-directed q-antitrypsin variant. Eric D. A n - derson, Laurel Thomas, Joel S. Hayflick, and Gary Thomas
24910 Biosynthesis of the prohormone convertase PC2 in
Fu-Sheng Shen, Nabil G. Seidah, and Iris Lindberg Chinese hamster ovary cells and in rat insulinoma cells.
24959 Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines. Masanobu Koide, Yasuhiro Ka- wahara, Ichiro Nakayama, Terutaka Tsuda, and Mitsuhiro Yokoyama
24990 Impaired biosynthesis of phosphatidylcholine causes a decrease in the number of very low density lipoprotein particles in the Golgi but not in the endoplasmic retic-
Antonio E. Rusijlol, Douglas G. Scraba, and Dennis E. Vance ulum of rat liver. Henkjan J . Verkade, Darren G. Fast,
25001 Palmitoylation is required for signaling functions and
gaertner, David H. Chu, Paul Wilson, Mark J . Levls, and membrane attachment of G and G&. Philip B. Wede-
Henry R. Bourne
25009 Endotoxin induces rapid protein tyrosine phosphoryl-
Jiing-Dwan Lee, Peter s. Tobias, and Richard J . Uleuitch ation in 70Z/3 cells expressing CD14. Jiahuai Hun,
25019 Role of glucokinase and glucose-6-phosphatase in the
by insulin. Nir Barzilai and Lucian0 Rossetti acute and chronic regulation of hepatic glucose fluxes
25041 Cloning of a membrane-associated protein which mod- ifies activity and properties of the Na+-D-glucose CO- transporter. Maike Veyhl, JOrg Spangenberg, Bernd PuSchel, Robert Poppe, Carmela Dekel, Gunter Fritzsch, Winfried H m e , and Hermann Koepsell
25108 The agrin receptor. Localization in the postsynaptic membrane, interaction with agrin, and relationship to the acetylcholine receptor. Jianyi Ma, Mary A. Nastuk, Beth A. McKechnie, and Justin R. Fallon
25132 1,25-Dihydroxyvitamin D1 activates Raf kinase and Raf perinuclear translocation via a protein kinase C-
and Bernard H. Davis dependent pathway. Trevor W . Lissoos, David W. A . Beno,
25139 Independent regulation of two cytoplasmic processing stages of the intermediate filament-associated protein filaggrin and role of CaZ+ in the second stage. K a t h r y n A. Resing, Nadra Al-Alawr, Cheryl Blomquist, Phrl Fleckman, and Beverly A. Dale
Indicates a Communication
viii
ix
25168
25184
25206
25239
25260
24572
24599
24607
24614
24642
24720
24726
24734
24785
24792
24868
25075
Movement of apolipoprotein B into the lumen of micro- somes from hepatocytes is disrupted in membranes en- riched in phosphatidylmonomethylethanolamine. Anto- nio E. Rusiriol, Edmond Y. W. Chan, and Jean E. Vance
Purification of a 110-kDa phosphoinositide phospholi- pase C that is activated by G-protein By-subunits. Jon- athan L. Blank, Karen Shaw, Annette H. Ross, and John H. Exton
Loading dependence of inositol 1,4,5-trisphosphate-in- duced CaZ+ release in the clonal cell line A7r5. Impli- cations for the mechanism of quantal CaZ+ release. Jan B. Parys, Ludwig Missiaen, Humbert De Smedt, and Rik Casteels
brain. Takaomi C. Saido, Masayuki Yokota, Shunsuke Nagao, Spatial resolution of fodrin proteolysis in postischemic
Ikuya Yamnura, Eiichi Tani, Takahide Tsuchiya, Koichi Su- zuki, and Seiichi Kawashima
of multisubunit ion-transporting ATPases. Identifica- Molecular requirements for the cell-surface expression
tion of protein domains that participate in Na,K-ATP- ase andH,K-ATPase subunit assembly. Vol. 268 (1993) 14342-14347. Cara J . Gottardi and Michael J . Caplan
ENZYMOLOGY Effect of mutations at active site residues on the activ- ity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors. Catherine S. Coleman, B r u e A . Stanley, and Anthony E. Pegg
Site-directed mutagenesis of rabbit muscle phospho- fructokinase cDNA. Mutations a t glutamine 200 affect the allosteric properties of the enzyme. Jauyi Li, Xiaomao Zhu, Malcolm Byrnes, Jeffrey W. Nelson, and Simon H. Chang
Kinetic mechanism of the DNA-dependent DNA polym- erase activity of human immunodeficiency virus re- verse transcriptase. Jen-Chih Hsieh, Shawn Zinnen, and Paul Modrich
Purification and sequence of rat extracellular super- oxide dismutase B secreted by CS glioma. Jean Willems, A n Zwijsen, Herman Slegers, Stefan Nicolac, Jayaram Betta- dapura, Jos Raymockers, and Thierry Scarcez
Electron transfer process in milk xanthine dehydro- genase as studied by pulse radiolysis. Kazw Kobayashi, Miyako Miki, Ken Okamoto, and Takeshi Nishino
specific rat sulfotransferase that catalyzes activation Isolation and expression of a cDNA encoding a male-
of N-hydroxy-2-acetylaminofluorene. Kiyoshi Nagata, Shogo Ozawa, Masaaki Miyata, Miki Shimada, Da- Wei Gong, Yasushi Yamazoe, and Ryuichi Kat0
Purification of an acyl-CoA hydrolase from rat intes- tinal microsomes. A candidate acyl-enzyme intermedi- ate in glycerolipid acylation. Richard Lehner and Arnis Kuksis
Interaction of bacterial luciferase with aldehyde sub- strates and inhibitors. Wilson A. Francisco, Husam M. Abu-Soud, Thomas 0. Baldwin, and Frank M. Raushel
Purification and characterization of an enzyme in- volved in oxidative carbon-carbon bond cleavage re- actions in the methionine salvage pathway of Klebsiella pneumoniae. Robert W. Myers, Jonathan W. Wray, Susan Fish, and Robert H. Abeles
Appendix. Cloning and sequence of the gene encoding
Klebsiella oxytoca. Ramaswamy Balakrishnan, Michael enzyme E-1 from the methionine salvage pathway of
Frohlich, Peter T. Rahaim, Keith Backmnn, and R. Rogers Yocum
Evidence for kinetically distinct forms of pp60""" with
J. A. Budde different K , values for their protein substrate. Raymond
Purification and characterization of a mitogen-acti- vated protein kinase tyrosine phosphatase from Xeno- pus eggs. Boris Sarceuic, Eleanor Erikson, and James L. Maller
25146 Phosphorylation of synthetic peptides containing Tyr- Met-X-Met motifs by nonreceptor tyrosine kinases in
Dunne A. Hinds, Allan R. Goldberg, and W. Todd Miller vitro. Pilar Garcia, Steven E. Shoelson, Shaji T. George,
25152 Molecular cloning of two abundant protein tyrosine kinases in Torpedo electric organ that associate with the acetylcholine receptor. Sheridan L. Swope and Richard L. Huganir
24564
24580
24683
24779
24824
24902
24950
25063
MEMBRANES AND BIOENERGETICS
decarboxylase from Veillonella parvula. Jon B. Huder Sequence of the sodium ion pump methylmalonyl-CoA
and Peter Dimroth
Cloning of a gene ( P S D l ) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by com- plementation of an Escherichia coli mutant. Constance J . Clancey, Shm-Chun Chang, and William Dowhan
Characterization of mutations in the b subunit of FIFo ATP synthase in Escherichia coli. Kimberly A. Mc-
and Brian D. Cain Cormick, Gabriele Deckers-Hebestreit, Karlheinz Altendorf,
ATP and A, adenosine receptor a onists mobilize intra- cellular calcium and activate K f and C1- currents in
ela Rugolo, Teresa Mastrocola, Claudia W h d e , Andrea Rasola, normal and cystic fibrosis airway epithelial cells. Mich-
Dieter C. Gruenert, Gwuanni Romeo, and Luis J. V. Galietta
Alterations in the electron transfer chain in mutant strains of Escherichia coli lacking phosphatidyletha- nolamine. Eugenia I. Mileykouskaya and William Dowhan
Dictyostelium discoideum. Mediation of cell-cell adhe- Characterization of the cell adhesion molecule gp24 in
sion via a Ca2+-dependent mechanism. Simuran Kaur Brar and Chi-Hung Siu
y-subunit. Tissue specificity produced by alternative Gene structure of human mitochondrial ATP synthase
and Yasuo Kagawa RNA splicing. Chie Matsuda, Hitoshi Endo, Shigeo Ohta,
Isolation of a protein activator of the clathrin-coated vesicle proton pump. Xiao-Song Xie, Bill P. Crider, and Dennis K. Stone
25084 Characterization of the nucleational core complex re-
lage matrix vesicles. Licia N. Y. Wu, Takayuki Yoshimori, sponsible for mineral induction by growth plate carti-
Ishikawa, and Roy E. Wuthier Brian R. Genge, Glenn R. Sauer, Thorsten Kirsch, Yoshinori
NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS
-24515 Optimization of an anti-HIV hairpin ribozyme by in vitro selection. Simpson Joseph and John M. Burke
024527 A small C-terminal region of the Escherichia coli MalT protein contains the DNA-binding domain. Dominique
Raibaud Vidal-Ingigliardi, Euelyne Richet, Oliuier Danot, and Oliuier
024539 Expression cloning of type 2 angiotensin I1 receptor reveals a unique class of seven-transmembrane recep- tors. Masashi Mukoyama, Masatoshi Nakajima, Masatsugu Horiuchi, Hiroyuki Sasamura, Richard E. Pratt, and Victor J . Dzau
24622 Probing the reactivity of the GTP- and GDP-bound conformations of elongation factor Tu in complex with
Parmeggiani the antibiotic GE2270 A. Pieter H. Anhrgh and Andrea
24647 Phosphorylation and active ATP hydrolysis are not
Reynisdottir, Heather E. Lorimer, Paula N. Friedman, Edith required for SV40 T antigen hexamer formation. Inga
H. Wang, and Carol Priues
24665 Fluid membranes with acidic domains activate DnaA, the initiator protein of replication in Escherichia coli. Celina E. Castuma, Elliott Crooke, and Arthur Kornberg
24669 CAMP regulates G-protein ai.2 subunit gene transcrip- tion in polarized LLC-PK1 cells by induction of a CCAAT box nuclear binding factor. T. Bernard Kinane, Cheng Shang, Jonathan D. Finder, and Louis Ercolani
Indicates a Communication
X
24677
24699
24774
24813
24855
24863
24892
24926
24933
24940
24967
24976
24986
25026
25033
25068
25095
Directional regulatory activity of cis-acting elements
promoter. Pirkko Heikkila, Raija Soininen, and Karl in the bidirectional al(1V) and a2(IV) collagen gene
Tryggvason
How do "Znl Cy%" proteins distinguish between similar upstream activation sites? Comparison of the DNA- binding specificity of the Gal4 protein in vitro and in uiuo. Sanjay Vashee, Huagiang Xu, Stephen A. Johnston, and Thomas Kodadek
quences is affected by platinum antitumor drugs. Jose The anti Z-DNA reactivity of Z-DNA forming se-
Manuel Carlos Lopez, and Carlos Alonso Manuel Perez-Martin, Jose Maria Requena, Dan Craciunescu,
The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein. Dennis Dooijes, Marc van de Wetering, Lion Knippels, and Hans Clevers
Drosophila embryos. Effects of reaction conditions and Processivity of mitochondrial DNA polymerase from
enzyme purity. Andrea J . Williams, Catherine M. Wernette, and Laurie S. Kaguni
Characterization of wheat germ protein synthesis ini- tiation factor eIF-4C and comparison of eIF-4C from wheat germ and rabbit reticulocytes. Richard T. Timmer, Sandra R. Lax, Diane L. Hughes, William C. Merrick, Joanne M. Ravel, and Karen S. Browning
Three clustered S p l sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat. Yues R. Boisclair, Alexandra L. Brown, Stefan0 Casola, and Matthew M. Rechler
of the plasmid RK2 replication initiation protein TrfA Essentiality of the three carboxyl-terminal amino acids
for DNA binding and replication activity in Gram- negative bacteria. Joan L i n Cereghino and Donald R. Helinski
Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme
Felder class. Yao- W u Zheng, Monica Bey, Hang Liu, and Michael R.
Effects of integration and replication on transcription of the HIV-1 long terminal repeat. K w n - T e h Jeang, Ben Berkhout, and Bora Dropulic
Post-translational processing of proopiomelanocortin
duced by a POMC-Simian virus 40 large T antigen (POMC) in mouse pituitary melanotroph tumors in-
transgene. Malcolm J. Low, Bin Liu, Gary D. Hammer, Marcel0 Rubinstein, and Richard G. Allen
transcriptional initiation complex and the hormone- Dynamic aspects of DNA/protein interactions in the
boxykinase promoter in uiuo. Steven Faber, Richard M. responsive domains of the phosphoenolpyruvate car-
O'Brien, Enyu Imai, Daryl K. Granner, and Roger Chalkley
Identification of the vaccinia virus mRNA guanyl- transferase active site lysine. Edward G. Niles and Linda Christen
Enhanced activation of the human histone H2B pro- moter by an Oct-1 variant generated by alternative splicing. Gokul Das and Winship Herr
RNA polymerases IIA and I10 have distinct roles dur- ing transcription from the TATA-less murine dihydro- folate reductase promoter. Mona E. Kang and Michael E. Dahmus
Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells. Philippe Gasque, Alexander Ischenko, Jocelyne Legoedec, Claire Mauger, Marie-Thirese Schouft, and Marc Fontarne
Angiotensin I1 stimulates the synthesis of angiotensin- ogen in hepatocytes by inhibiting adenylylcyclase ac- tivity and stabilizing angiotensinogen.mRNA. Christoph Klett, Ruiner Nobrlrng, Peter Grerschlk, and Eberhard Hackenthal
25162
25192
25197
25221
25229
25244
25253
'24547
'24555
24629
24635
24707
24742
24758
24838
24873
24916
25015
Two additional cases of osteogenesis imperfecta with substitutions for glycine in the a 2 (I) collagen chain. A regional model relating mutation location with pheno- type. Qin Wang, Bonnie M. Orrison, and Joan C. Marini
Function of the GrpE heat shock protein in bidirec- tional unwinding and replication from the origin of phage X. Claire Wyman, Christos Vasilikiotis, Debbie Ang, Costa Georgopoulos, and Harrison Echols
Osteogenic protein-1 regulates L1 and neural cell adhe-
Perides, Guang Hu, David C. Rueger, and Michael E. Charness sion molecule gene expression in neural cells. George
The role of nucleotides conserved in eukaryotic initia-
Harold J. Drabkin, Bernhard Helk, and Uttam L. RajBhandary tor methionine tRNAs in initiation of protein synthesis.
Stable fluorescent dye-DNA complexes in high sensitiv-
to heat shock transcription factor. Hays S. Rye, Becky L. ity detection of protein-DNA interactions. Application
Drees, Hillary C. M. Nelson, and Alexander N. Glazer
In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myo- sin light chain-2 gene is independent of heart tube
Stephen J. Fuller, Sylvia M. Evans, Gary Lyons, Christel formation. Wanda C. Miller-Hance, Monique LaCorbiere,
Schmidt, Jeffrey Robbins, and Kenneth R. Chien
Characterization and chromosomal mapping of the hu- man thromboxane Az receptor gene. Rolf M. Ntising, Masakazu Hirata, Akira Kakrzuka, Toshihiko Eki, Kazuo Ozawa, and Shuh Narumiya
PROTEIN CHEMISTRY AND STRUCTURE In uiuo control of redox potential during protein folding catalyzed by bacterial protein disulfide-isomerase (DsbA). Martina Wunderlich and Rudi Glockshuber
Carboxyl terminus is essential for intracellular folding of chloramphenicol acetyltransferase. J o h n Robben, Jan Van der Schueren, and Guido Volckaert
Biochemical comparisons of the Saccharomyces cere- uisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain. Yi Zheng, Matthew J. Hart, Katsuhiro Shinjo, Tony Evans, Alan Bender, and Richard A. Cerione
Ca2+-induced folding and aggregation of skeletal mus- cle sarcoplasmic reticulum calsequestrin. The involve-
Keith Dunker, Carla R. Wesson, and William R. Trumble ment of the trifluoperazine-binding site. Zhaoping He, A.
Refined structure in solution of the sea anemone neu- rotoxin ShI. Gavin R. Wilcox, Rasmus H. Fogh, and Raymond S. Norton
Behavior of Cys-707 (SH1) in myosin associated with
linked directly to the sulfur atom. Toshiaki Hiratsuka ATP hydrolysis revealed with a fluorescent probe
Functional roles of valine 37 and glycine 38 in the mobile loop of porcine cytosolic aspartate aminotrans- ferase. Qian- Wen Pan, Sumio Tanase, Yuhji Fukumoto, Fuji0 Nagashima, Sangkee Rhee, Paul H. Rogers, Arthur Arnone, and Yoshimasa Morino
Alteration of vitronectin. Characterization of changes induced by treatment with urea. Steven V. Bittorf, Eliot C. Williams, and Deane F. Masher
The interaction of N-ethyl retinamide with plasma ret- inol-binding protein (RBP) and the crystal structure of
Zanotti, Giorgio Malpeli, and Rodolfo Berni the retinoid-RBP complex at 1.9-A resolution. Giuseppe
Diversity of intermediate filament structure. Evidence that the alignment of coiled-coil molecules in vimentin
Peter M. Steinert, Lyuben N. Marekov, and David A. D. Parry is different from that in keratin intermediate filaments.
Binding of collagen XIV with the dermatan sulfate side chain of decorin. Bernard Font, Elisabeth Aubert-Foucher, Denise Goldschmidt, Denise Elchenberger, and Michel van der Rest
Indicates a Communication
xi
25054 Identification of the major phosphorylation domain of murine mdr l b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites. George A. Orr, Edward R-H. Nan, Paul C. Browne, Edward Nieves, Bri id M. O’Connor, Chin-Ping Huang Yang, and Susan BancfHorwitz
25124 Identification of a secondary FcyRI binding site within a genetically engineered human I G antibody. M. Suz- anne c,hap el, ~ u u d E Isenman, R. Jomen , Yuan Yuan xu , and McchefH. Klein ‘
25176 Characterization of the lectin from the bulbs of Eran- this hyernalis (winter aconite) as an inhibitor of protein synthesis. M. Arun Kumar, David E. Timm, Kenneth E. Neet, Whyte G. Owen, Willy J. Peumans, and A. Gururaj Rao
25213 Calmodulin-cardiac troponin C chimera. Effects of do- main exchange on calcium binding and enzyme activa- tion. Samuel E. George, Zenghua Su, Duju Fan, and Anthony R. Means
Abeles, Robert H., 24785 Abu-Soud, Husam M., 24734 AI-Alawi, Nadia, 25139 Allen, Richard G., 24967 Alonso, Carlos, 24774 Altendorf, Karlheinz, 24683 Alvarez, Javier, 24751 Anborgh, Pieter H., 24622 Anderson, Eric D., 24887 Ang, Debbie, 25192 Arnone, Arthur, 24758
Aubert-Foucher, Elisabeth, Aruffo, Alejandro, 24655
Backman, Keith, 24792 Balakrishnan, Ramaswamy,
Balzarini, Jan, 24591 Baldwin, Thomas O., 24734
Bardhan, Smriti, 24543 Barzilai, Nir, 25019 Bender, Alan, 24629 Beno, David W. A,, 25132 Berkhout, Ben, 24940 Berni, Rodolfo, 24873 Bettadapura, Jayaram, 24614 Bey, Monica, 24933
Bittorf, Steven V., 24838 Biller, Scott A,, 24832
Blank, Jonathan L., 25184 Blomquist, Cheryl, 25139 Bohman, Christina, 24591 Boisclair, Yves R., 24892
Brar, Simuran Kaur, 24902 Bourne, Henry R., 25001
Brown, Alexandra L., 24892 Browne, Paul C., 25054 Browning, Karen S., 24863 Budde, Raymond J. A,, 24868
Byrnes, Malcolm, 24599 Burke, John M., 24515
Cain, Brian D., 24683 Caplan, Michael J., 25260 Casola, Stefano, 24892 Casteels, Rik, 25206
Cereghino, Joan Lin, 24926 Castuma, Celina E., 24665
Cerione, Richard A,, 24629 Chabre, Marc, 24531 Chalkley, Roger, 24976 Chan, Edmond Y. W., 25168 Chan, Po-Ying, 24655 Chang, Shao-Chun, 24580 Chang, Simon H., 24599 Chappel, M. Suzanne, 25124 Chardin, Pierre, 24531 Charness, Michael E., 25197
Chien, Kenneth R., 25244 Chen, Hao-Chia, 24808
Christen, Linda, 24986 Chu, David H., 25001 Ciosek, Carl P., Jr., 24832 Clancey, Constance J., 24580 Clevers, Hans, 24813 Coleman, Catherine S., 24572 Craciunescu, Dan, 24774 Crain, Richard, 24559 Crider, Bill P., 25063
25015
24792
Crooke, Elliott, 24665
Dahmus, Michael E., 25033 Dale, Beverly A,, 25139 Danot, Olivier, 24527 Das, Gokul, 25026 Davis, Bernard H., 25132 Deckers-Hebestreit, Gabriele,
De Clercq, Erik, 24591 Dekel, Carmela, 25041 Dentler, William L., 24796 De Smedt, Humbert, 25206 D’Eustachio, Peter, 24880 Dickson, John K., Jr., 24832 Dimroth, Peter, 24564 Dooijes, Dennis, 24813 Dowhan, William, 24580,
Drabkin, Harold J., 25221 Drees, Becky L., 25229 Dropulic, Boro, 24940 Dunker, A. Keith, 24635 Dzau, Victor J., 24539
Eichenberger, Denise, 25015 Echols, Harrison, 25192
Eki, Toshihiko, 25253 Endo, Hitoshi, 24950 Ercolani, Louis, 24669 Erikson, Eleanor, 25075 Evans, Sylvia M., 25244 Evans, Tony, 24629 Exton, John H., 25184
Faber, Steven, 24976 Fallon, Justin R., 25108 Fan, Daju, 25213 Fast, Darren G., 24990 Felder, Michael R., 24933 Finder, Jonathan D., 24669
Fish, Susan, 24785 Finley, Fred, 24818
Fleckman, Phil, 25139 Fogh, Rasmus H., 24707 Font, Bernard, 25015 Fontaine, Marc, 25068 Francisco, Wilson A,, 24734 Franco, Michel, 24531 Fridland, Arnold, 24591
Fritzsch, Gunter, 25041 Friedman, Paula N., 24647
Frohlich, Michael, 24792 Fujisawa, Kazuko, 24535 Fukumoto, Yuhji, 24758 Fuller, Stephen J., 25244 Furusawa, Iwao, 25118
Galietta, Luis J. V., 24779 Garcia, Pilar, 25146 Garcia-Sancho, Javier, 24751 Gasque, Philippe, 25068 Gautam, Narasimhan, 24519 Genge, Brian R., 25084
George, Shaji T., 25146 George, Samuel E., 25213
Georgopoulos, Costa, 25192
Glazer, Alexander N., 25229 Gierschik, Peter, 25095
Glockshuber, Rudi, 24547 Goldberg, Allan R., 25146
24683
24824
AUTHOR INDEX
Goldschmidt, Denise, 25015 Gong, Da-Wei, 24720 Gordon, Eric M., 24832 Gottardi, Cara J., 25260 Granner, Daryl K., 24976
Gruenert, Dieter C., 24779 Grossman, Albert, 24880
Guroff, Gordon, 24808
Haase, Winfried, 25041 Hackenthal, Eberhard, 25095 Haddock, Nathan, 24559 Hakamada, Kazuhiko, 25118 Hall, Andrew G., 24523 Hamakubo, Takao, 24543 Hamilton, Kelly A,, 24832 Hammer, Gary D., 24967 Han, Edward K.-H., 25054 Han, Jiahuai, 25009 Harrity, Thomas W., 24832 Hart, Matthew J., 24629 Hayflick, Joel S., 24887 He, Zhaoping, 24635 Heikkila, Pirkko, 24677 Heinstein, Peter F., 24559 Helinski, Donald R., 24926 Helk, Bernhard, 25221 Herdewijn, Piet, 24591 Herr, Winship, 25026 Hinds, Duane A,, 25146 Hirata, Masakazu, 25253
Hiratsuka, Toshiaki, 24742 Hirata, Yoko, 24808
Horiuchi, Masatsugu, 24539
Horwitz, Susan Band, 25054 Horska, Kvetoslava, 24591
Hosoya, Yukio, 24551 Hsieh, Jen-Chih, 24607 Hu, Guang, 25197 Huder, Jon B., 24564 Huganir, Richard L., 25152 Hughes, Diane L., 24863 Hwang, Yu-Wen, 24692
Imai, Enyu, 24976 Inagami, Tadashi, 24543 Inanobe, Atsushi, 24551 Inui, Hiroshi, 24543 Ischenko, Alexander, 25068 Isenman, David E., 25124 Ishikawa, Yoshinori. 25084
Jahangir, Arshad, 24551 Jeang, Kuan-Teh, 24940 Johnston, Stephen A,, 24699 Jolibois, Kern G., 24832 Joseph, Simpson, 24515
Kagawa, Yasuo, 24950 Kaguni, Laurie S., 24855 Kakizuka, Akira, 25253 Kambayashi, Yoshikazu,
Kang, Mona E., 25033
Katada, Toshiaki, 24551 Karlsson, Anna, 24591
Kato, Ryuichi, 24720
Kawashima, Seiichi, 25239 Kawahara, Yasuhiro, 24959
Kinane, T. Bernard, 24669 Kirkland, The0 N., 24818
24543
Kirsch, Thorsten, 25084 Kisselev, Oleg, 24519 Kiuchi, Kazutoshi, 24808 Klein, Michel H., 25124 Klett, Christoph, 25095 Knippels, Lion, 24813 Kobayashi, Kazuo, 24642 Kodadek, Thomas, 24699 Koepsell, Hermann, 25041 Koide, Masanobu, 24959 Kornberg, Arthur, 24665 Kuksis, Arnis, 24726 Kumagai, Naokazu, 24535 Kumar, M. Arun, 25176 Kunselman, Lori K., 24832 Kurachi, Yoshihisa, 24551 LaCorbiere, Monique, 25244 Lawrence, R. Michael, 24832 Lax, Sandra R., 24863 Leamon, Christopher P.,
Lee, J.-D., 24818 Lee, JiingDwan, 25009 Legendre, Laurent, 24559 Legoedec, Jocelyne, 25068 Lehner, Richard, 24726 Leturcq, Didier, 24818
Li, Jauyi, 24599 Levis, Mark J., 25001
Lightowlers, Robert N.,
Lindberg, Iris, 24910 Lissoos, Trevor W., 25132 Liu, Bin, 24967 Liu, Hong, 24933 Logan, Janette V. H., 24832 Lopez, Manuel Carlos, 24774 Lorimer, Heather E., 24647 Low, Malcolm J., 24967 LOW, Philip S., 24559, 24847 Lyons, Gary, 25244 Ma, Jianyi, 25108 Magnin, David R., 24832 Maller, James L., 25075 Malpeli, Giorgio, 24873
Marini, Joan C., 25162 Marekov. Lyuben N., 24916
Mastrocola, Teresa, 24779 Matsuda, Chie, 24950 Matsuno, Ryuichi, 25118 Mauger, Claire, 25068 McCormick, Kimberly A,,
McKechnie, Beth A,, 25108
Merrick, William C., 24863 Means, Anthony R., 25213
Miki, Miyako, 24642
Mileykovskaya, Eugenia I.. Milbrandt, Jeffrey, 24808
Miller, W. Todd, 25146 Miller-Hance, Wanda C.,
Missiaen, Ludwig, 25206 Miyata, Masaaki, 24720 Modrich, Paul, 24607 Montero, Mayte, 24751 Mookhtiar, Kasim A,, 24832
24847
24523
24683
24824
25244
Moriarty, Ann, 24818 Morii, Narito, 24535 Morino, Yoshimasa, 24758 Mosher, Deane F., 24838 Mossie, Kevin, 24880 Mukoyama, Masashi, 24539 Musacchio, Jose M., 24880 Myers, Robert W., 24785
Nagano, Yukio, 25118 Nagao, Shunsuke, 25239 Nagashima, Fujio, 24758 Nagata, Kiyoshi, 24720 Nakajima, Masatoshi, 24539 Nakayama, Ichiro, 24959 Narumiya, Shuh, 24535,
Nastuk, Mary A,, 25108 Neet, Kenneth E., 25176 Nelson, Hillary C. M., 25229 Nelson, Jeffrey W., 24599 Nemoto, Yasuo, 24535 Nicolai, Stefan, 24614 Nieves, Edward, 25054 Niles, Edward G., 24986 Nishino, Takeshi, 24642 Nobiling, Rainer, 25095 Nohara, Keiko, 24997
Nusing, Rolf M., 25253 Norton, Raymond S., 24707
O’Connor, Brigid M., 25054 O’Brien, Richard M., 24976
Ohta, Shigeo, 24950 Okamoto, Ken, 24642 Oomen, R., 25124 Orr, George A., 25054
Owen, Whyte G., 25176 Orrison, Bonnie M., 25162
Ozawa, Shogo, 24720 Ozawa, Kazuo, 25253
Pan, Qian-Wen, 24758 Paris, Sonia, 24531 Parmeggiani, Andrea, 24622,
Parry, David A. D., 24916
Pastan, Ira, 24847 Parys, Jan B., 25206
Pegg, Anthony E., 24572 Perez-Martin, Jose Manuel,
Perides, George, 25197 Peumans, Willy J., 25176
Poullet, Patrick, 24692 Poppe, Robert, 25041
Pratt, Richard E., 24539 Preiss, Thomas, 24523 hives , Carol, 24647 Puschel, Bernd, 25041
Rahaim, Peter T., 24792 Raibaud, Olivier, 24527 RajBhandary, Uttam L.,
Rao, A. Gururaj, 25176 Rasola, Andrea, 24779
Ravel, Joanne M., 24863 Raushel, Frank M., 24734
Raymackers, Jos, 24614 Rechler, Matthew M., 24892
25253
24692
24774
25221