wael el-rifai, m.d., ph.d. curriculum vitae 1(24) · 1986 – 87 medical intern, ain shams...

Wael El-Rifai, M.D., Ph.D. Curriculum Vitae 1(24)

CURRICULUM VITAE

Name: Wael El-Rifai, MD, Ph.D. Address: 1255 MRB IV Light Hall 2215 Garland Ave Phone: 615-322-7934 Born: September 23, 1963 Citizenship: United States of America EDUCATION 1980 – 86 School of Medicine, Ain Shams University, MD “with honor”, Cairo, Egypt 1988 – 92 School of Medicine, Ain Shams University, MSc. in Human Genetics “with honor”, Cairo,

Egypt 1991 – 93 School of Medicine, Ain Shams University, DM. in Pediatrics, Cairo, Egypt 1993 – 96 School of Medicine, University of Helsinki, Ph.D. in Cancer Genetics, Helsinki, Finland PROFESSIONAL EXPERIENCE 1986 – 87 Medical Intern, Ain Shams University Hospitals, Cairo, Egypt 1988 – 90 Medical Research Resident “Assistant Researcher”, Department of Human Genetics,

National Research Center, Cairo, Egypt 1990 – 92 Research Associate, Department of Human Genetics, National Research Center, Cairo,

Egypt 1993 – 94 Researcher (Center for International Mobility, Finland), at the Department of Medical

Genetics, University of Helsinki, Finland 1994 – 97 Research Scientist, Department of Medical Genetics, University of Helsinki, Finland 1998 – 00 Associate Professor of Molecular Cancer Genetics, Department of Medical Genetics,

Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Finland 2000 – 02 Assistant Professor of Medicine “Tenure Track”, University of Virginia 2003 – 05 Associate Professor of Medicine “Tenure Track”, University of Virginia 2003 – 05 Associate Professor of Biochemistry and Molecular Genetics “Tenure Track”, University of

Virginia 2003 – 05 Director of Gastrointestinal Oncology Research, University of Virginia 2005 – Professor of Surgery and Cancer Biology, Vanderbilt University Medical Center 2005 – Director, Surgical Oncology Research, Vanderbilt University Medical Center and

Vanderbilt-Ingram Cancer Center 2011 – William Scott Jr. Chair of Surgery, Vanderbilt University Medical Center AD-HOC REVIEWER FOR INTERNATIONAL SCIENTIFIC JOURNALS Cancer Research, Molecular Cancer Research, Clinical Cancer Research, Molecular Cancer Therapeutics, Gut, Genomics, Oncogene, Clinical Cancer Research, Gastroenterology, Cancer Genetics and Cytogenetics, Genes Chromosomes & Cancer, American Journal of Pathology, Modern Pathology, Ann Surgery, Surgical Oncology, British Journal of Cancer, International Journal of Cancer, Laboratory Investigations, Science STKE.


HONORS/AWARDS/PRIZES 1986 M.D. with honor, Faculty of Medicine, Cairo, Egypt 1992 FEBS scholarship 1993 CIMO: Centre for International Mobility, Finland, research fellow 1994 CIMO: Centre for International Mobility, Finland, research fellow 1995 University of Helsinki Graduate School, scholarship 1996 University of Helsinki Graduate School, scholarship 1997 University of Helsinki Research award 1999 ESHG European Society of Human Genetics, scholarship 2000 ESHG European Society of Human Genetics, scholarship 2008 – Council member of the Gastrointestinal Oncology Section, American Gastroenterology

Association 2009 – Member in Esophago-gastric Task Force, NCI 2011 – Member of the Steering Committee of the Gastroenterology Research Group, American

Gastroenterology Association SOCIETIES 1993 – Active Member of the European Society of Human Genetics 2000 – Active Member of the American Society of Human Genetics 2000 – Active Member of the American Association of Cancer Research 2001 – Active Member of the American Association of Gastroenterology 2001 – Active Member of the American Association for the Advances of Science MILITARY SERVICE 1988 – 89 Lieutenant, Military Hospital for Pulmonary Diseases, Cairo, Egypt TRAINING AND MENTORSHIP ACTIVITIES Dr. El-Rifai has been a mentor for several graduate and post graduate students. Dr. El-Rifai has also trained several post doctoral fellows, residents, fellows, and junior faculty. All trainees of Dr. El-Rifai have published the results of their assigned projects in peer reviewed journals. Supervisor and/or mentorship of Ph.D. Students: - Asta Varis (defended on 4/2004), Faculty of Medicine, University of Helsinki, Finland

- Maija Wolf, (defended on 4/2000), Faculty of Medicine, University of Helsinki, Finland

- Eeva Kettunen, (defended on 4/2004), Faculty of Medicine, University of Helsinki, Finland

- Tarja Huhta, Ph.D. student, Faculty of Medicine, University of Helsinki, Finland

- Toni Naji, Ph.D. student, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Training of graduate students:

- Adam Johnson (2002-2004): 3rd-4th year student, College of Arts and Sciences, University of Virginia


- Shoaib Afridi (2004): 2nd year student, School of Medicine, St. George's University

- Jennifer Ascano (2000-2001): 3rd-4th year student, College of Arts and Sciences, University of Virginia

- Andy Beckler (2002-2003): 1st year student, school of Medicine, University of Virginia

- Chen Zheng (2011- present): Ph.D. Student, Vanderbilt University Mentorship and training of post doctoral fellows:

- Yan Aalto: Department of Medical Genetics, University of Helsinki

- Narren Sankpal (2003-2005): Division of Gastroenterology University of Virginia

- Alaa Awad (2003-2005): Division of Nephrology, University of Virginia

- Abbes Belkhiri (2003-2005): Division of Gastroenterology University of Virginia

- Patricia McChesney (2004-2005): Division of Gastroenterology University of Virginia

- Nataliya Pidkovka (2004): Division of Gastroenterology University of Virginia

- Mohamed Dahman (2003-2005): Division of Gastroenterology University of Virginia

- Altaf Dar, Ph.D. (2005-present): Surgical Oncology, Vanderbilt University

- Mohamed Razvi, M.D. (2005-present): Surgical Oncology, Vanderbilt University

- DunFa Peng, M.D., Ph.D. (2005-present): Surgical Oncology, Vanderbilt University

- Anna Vilgelm, Ph.D. (2005-present): Surgical Oncology, Vanderbilt University

- Jinxiong Wei, Ph.D. (2005-present): Surgical Oncology, Vanderbilt University

- Mohammed Soutto, Ph.D. (2008-present): Surgical Oncology, Vanderbilt University Training of residents and fellows:

- Sonja Kiuru-Kuhlefelt (1996-1999): Department of Medical Genetics, University of Helsinki

- Johana Tapper (1997-2000): Department of Obstetrics and Gynecology, University of Helsinki

- Charles Fox (2004), fellow of Gastroenterology, University of Virginia

- Brian Rundall (2005): Resident of Surgery, University of Virginia

- Ok-Jae Lee (2004-2005): Visiting Gastroenterologist, University of Seoul, Korea

- Ketsia Pierre (2006-2007): Resident, Department of Surgery

- Kaushik Mukherjee (2008-2010): Resident, Department of Surgery Mentorship of faculty (Name, Years, Current position):

- Alexander Zaika, Ph.D. (2003-2004), Assistant Professor, Vanderbilt University

- Martha Shrubsole, Ph.D. (2005-present): Assistant Professor of Epidemiology. Vanderbilt University

- Alexander Parikh, M.D. (2005-2008): Assistant Professor of Surgery, Vanderbilt University

- Wooin Lee, Ph.D. (2006- 2008): Assistant professor of Pharmacology, University of Kentucky

- Craig Lockhart, M.D. (2007-2009): Associate professor of Oncology, Washington University

- John Phay M.D. (2007-2009): Assistant professor of Surgery, University of Ohio

- Abbes Belkhiri (2004-present): Assistant professor of Surgery, Vanderbilt University

- Nipun Merchant (2005-2008): Associate Professor Surgery, Vanderbilt University

- Patrcicia McChesney (2004-2005): Assistant Professor, Yale University

- Claudia Andl, Ph.D. (2008 – 2011): Assistant Professor Surgery, Vanderbilt University Ph.D. Thesis Committee


4/1999 (examiner): Tero Järvinen, M.D., Faculty of Medicine, University of Tampere, Finland 2006 – 09 Toni Nagy, Vanderbilt University EDITORIAL BOARD MEMBERSHIP 2009 – Associate Editor, Digestive Disease and Sciences 2009 – Editorial Board, Gastroenterology 2009 – Editorial Board, World Journal of Gastroenterology 2006 – Editorial Board, Biomarker Insights 2007 – Editorial Board, Bioinformatics and Biology Insights 2010 – Academic Editor, PLosONE REVIEW FOR GRANT PROPOSALS 2009 – Regular member (2011 - ) and Ad-Hoc (2009 – 2010), Basic Mechanisms of

Chemotherapeutics (BMCT) study section, NCI, NIH 2003 – 2009 Regular member (2004 – 2009) and Ad-Hoc (2003 – 2004), Tumor Progression and

Metastases (TPM) study section, NCI, NIH 2010 – Ad-Hoc, Basic Mechanisms of Chemotherapeutics (BMCT) study section, NIH 2006 – Ad-hoc member, ZRG1 F10-H 21L, fellowship study section, NIH 2007 – Ad-Hoc, AED-ZRG1ONC-S (02) study section, NCI 2005 Ad-Hoc, ZRG1 ONC-J study section, NCI 2005, 2007, 2009: Ad-Hoc member, ZCA1 SRC: CCSG (Cancer Center Support Grant) study section, NCI 2005 ZRG1 DIG-C (02) study section, NIH 2005 ZRG1 ONC-J, study section, NIH 2005 ZRG1 NRSA postdoctoral fellowship, NIH 2005 Clinical Integrated Gastrointestinal Pathobiology (CIGP) study section, NIH 2004 Clinical Integrated Gastrointestinal Pathobiology (CIGP) study section, NIH 2003 – 04 German Cancer Institute 2002 Association for International Cancer Research 2000 Finnish Cancer Institute FUNDED RESEARCH AWARDS (Past Five Years) Agency: NIH/NCI, 2R01-CA93999-01, 2002-2013 Principal Investigator: Wael El-Rifai Title: Targets of Gene amplification and overexpression at 17q in gastric cancer. Role: Principal Investigator Agency: NIH/NCI, R01-CA106176-01, 2003-2015 Principal Investigator: Wael El-Rifai Title: Molecular Pathobiology of Barrett’s Tumorigenesis


Role: Principal Investigator Agency: NIH/NCI, R01-CA133738, 2009-2012 Principal Investigator: Wael El-Rifai Title: The Role of t-Darpp in Esophageal Adenocarcinomas Role: Principal Investigator Agency: NIH/NCI, R01-CA131225, 2009-2014 Principal Investigator: Wael El-Rifai Title: The role of Aurora Kinase A in Upper Gastrointestinal Adenocarcinomas Role: Principal Investigator Agency: NIH/NCI, T32CA106183, 2010-2015 Principal Investigator: Wael El-Rifai Title: Surgical Oncology Training Grant Role: Principal Investigator Agency: USDA: 58-3148-8-166, 2009-2011 Principal Investigator: Wael El-Rifai Title: Towards Pathobiology of Inflammatory Breast Cancer Role: Principal Investigator Agency: NIH/NCI, R01 CA108956, 2006-2011 Principal Investigator: Alexander Zaika Title: The role of p73 in gastric tumorigenesis Role: Co-investigator Agency: NIH/NCI, R01 CA138833, 2010-2015 Principal Investigator: Alexander Zaika Title: p53 in gastric cancer development Role: Co-investigator Agency: NIH/FDA, R01FD003522 , 2010-2014 Principal Investigator: Jeffrey Sosman Title: Inhibition of Aurora Kinase A as Treatment for Melanoma Role: Co-investigator Agency: NIH/NCI, R21- CA111541, 2006-2008 Principal Investigator: Wael El-Rifai Title: Early Biomarkers of Gastric Tumorigenesis Role: Principal Investigator Agency: NIH/NCI, R21 CA129655, 2007-2009 Principal Investigator: Alexander Zaika Title: Integral Activity of the p53 Family and its Role in Progression of Colon Tumors


Role: Co-investigator Agency: NIH 1S10 RR019911-01 2005-2006 Principal Investigator: Stuart S. Berr Title: 9.4 Tesla MR Scanner for Murine Imaging Role: Co-investigator Agency: NIH/NIDDK P30 DK067629 2004-2005 Principal Investigator: Fabio Cominelli Title: UVA Digestive Health Research Center Role: Co-Director of Molecular and Gene Expression Core Agency: NIH/NCI, R01 CA67900-06, 2000-2005 Principal Investigator: Steven Powell Title: Genetic alteration in gastric cancer Role: Co-investigator Agency: Cancer Center, University of Virginia, 2002-2004 Principal Investigator: Wael El-Rifai Title: TFF1 in gastric cancer INVITED LECTURES 1. University of Colorado, Department of Surgery Grand Rounds, February 28, 2011, Integrative

Cancer Genomics: From Mouse to Man. 2. BGICC 2011, Breast -Gynecological International Cancer Conference. January 14, 2011. Can we

Blame Gene Amplification at the ERBB-2 Amplicon for Trastuzumab Resistance. 3. ACOSOG 2010 Semi-Annual Meeting, Thoracic Committee. November 12, 2010. Molecular

concepts in esophageal adenocarcinoma. 4. University of Colorado Cancer Center Symposium, Invited Professor, November 2, 2010. The

Genome Complexity in Cancer Therapeutics. 5. P. Universidad Catolica de Chile, Santiago, Chile, Invited Professor, September 20, 2010.

Genomics and Therapeutics. 6. Washinton University School of Medicine, St. Louis, Invited Professor, May 13, 2010. The Road to

Targeted Therapy. 7. Erlangen University School of Medicine, Nurenberg, Germany, Invited Professor, March 8, 2010.

The Genomic Complexity in Cancer Therapeutics. 8. 33rd Ain Shams University Annual Conference, Cairo, Egypt, March 4, 2010. The Genomics in

Cancer Therapy. 9. Meharry Medical College, Nashville, USA, January 27, 2010. The Genome Complexity in Cancer

Therapeutics. 10. University of Pennsylvania, Philadelphia, USA, November 4, 2009. From Genomics to

Therapeutics. 11. University of Hawaii Cancer Center, Hawaii, USA, September 26, 2009. The molecular road to

therapeutics.


12. 13th World Congress on Advances in Oncology, Crete, Greece. October 14-18, 2009. From Genomics to Therapeutics.

13. Eastern Cooperative Oncology Group, Ft. Lauderdale, FL, November 14-16, 2008, From Genomics to Therapeutics.

14. National Cancer Institute, Cairo, Egypt, July 13, 2008, Integrated Omic Approaches for Cancer Studies.

15. Digestive Disease Week 2006, Los Angeles, CA, May 21-24, 2006. COBRA1: A novel regulator of TFF1 transcription in upper gastrointestinal adenocarcinomas.

16. Institute of Pathology, Otto-von-Guericke University, Magdeburg, Germany. April 27, 2006. Functional Genomic in Upper Gastrointestinal Carcinomas.

17. Functional Genomics Course at Biomedicum Helsinki, Finland, April 24-25, 2006. Integrative Functional Genomics in Upper Gastrointestinal Carcinomas.

18. Integrated Genomics, Vanderbilt University Medical Center. March 28, 2006. A voyage in the genome of Upper Gastrointestinal Carcinomas.

19. Gastrointestinal Cancer Symposium, San Francisco, January 26-28, 2006. Loss of expression and DNA methylation of GPx3 in Barrett’s Tumorigenesis.

20. Gastrointestinal Cancer Symposium, Miami, Florida, January 26-28, 2005. Clustering of over-expressed genes in gastroesophageal carcinomas.

21. University of Vanderbilt, Ingram Cancer Center, November 11, 2004. Unraveling the genome in gastroesophageal carcinomas.

22. 9th World Congress on Advances in Oncology. Crete, Greece, October 14-16, 2004. DARPP-32 from neurotransmission to cancer.

23. 8th World Congress on Advances in Oncology, Crete, Greece. Molecular Targets in upper gastrointestinal carcinomas, October 16-18, 2003

24. XXXV Nordic Meeting of Gastroenterology, Helsinki, Finland. Unraveling the genome in upper gastrointestinal carcinomas, June 11-14, 2003

25. University of Cincinnati Cancer Center, Genes and the Genome in gastrointestinal malignancies, May 16, 2003

26. Southern Illinois Cancer Center, Springfield IL, Uncovering the genome in upper GI malignancies. November 18, 2002

27. King Faisal Specialty Hospital and Research Center, Riyadh, Saudi Arabia, Uncovering the Genome in GI malignancies. October 18, 2002

28. University of Massachusetts Medical School, Worcester MA, USA, Cancer Center. Novel technologies in gastric tumorigenesis, March 2002

29. University of Texas, South Western Medical School, Dallas TX, Novel technologies in Cancer Research. November, 15, 2001

30. The National Research Center, Cairo, Egypt. Gene amplification and expression in cancer. July 15, 2001

31. The National Institute of Health (NIH) workshop in gastrointestinal stromal tumors, Bethesda, USA. Recent molecular advances in GIST diagnosis and prognosis. April 2-3, 2001


32. The European Human Genetics Conference 2000, Amsterdam, Netherlands, Expression profiling in proximal stomach and gastro-esophageal junction adenocarcinomas using cDNA arrays technology. 27-30 May, 2000

33. University of Virginia, Health Science Center, U.S.A., “Novel cDNA array technology in gastric adenocarcinomas". February 5, 2000

34. Instructor at the Mouse Pathology Course, Viiki BioCenter, University of Helsinki, Helsinki, Finland “cDNA arrays in research” August 19-21, 1999

35. Instructor at the Chromosome and Gene Alterations in Cancer and their Clinical Significance, University of Helsinki, Finland, November 30-December 4, 1999

36. 13th International Chromosome Conference, September, Ancona, Italy. DNA Copy Number Changes in Development and Progression in Leiomyosarcomas of Soft Tissues. 9-12, 1998

37. Institute of Medical Technology, Tampere, Finland “Recent technologies in cancer diagnosis and research” October 11, 1998

38. First International symposium on GIST, Helsinki, Finland “DNA copy number changes in GIST” September 25-26, 1998

39. XIII International Chromosome Conference, Ancona, Italy “DNA copy number changes in development and progression in leiomyosarcomas of soft tissues”. September 9-12, 1998

40. XV Meeting of the European Association for Cancer Research, Stockholm, Sweden. “DNA copy number changes in development and progression in leiomyosarcomas of soft tissues”. August 15-19, 1998

41. Department of Hematology, Perugia University Hospital, Italy, Minimal residual disease using metaphase-FISH: advantages and limitations. 15-30, April, 1998

42. Department of Hematology, Perugia University Hospital, Italy, CGH in refractory leukaemia. 15-30, April, 1998

43. XIVth Meeting of the International Society of Haematology, European & African Division, Stockholm International Fair, Stockholm, Sweden. “Changes in DNA copy number and chromosomal breakpoints in refractory acute myeloid leukemia”. Aug 30 - Sept 4, 1997

44. Instructor at the Strategies and Methods of Physical Mapping and Positional Cloning Course, Department of Medical Genetics, University of Helsinki, Finland. November 19-23, 1996

PUBLICATIONS 1. El-Rifai W, Aboul-Ezz EHA, El-Sinbawy AH, El-Sawi M, El-Khayat HA, Temtamy SA: Is deafness a

feature of Coffin-Siris Syndrome J Med Res Inst 14:263-276, 1993

2. El-Rifai W, Pettersson T, Larramendy ML, Knuutila S: Lineage involvement and karyotype in a patient with myelodysplasia and blood basophilia. European Journal of Haematology 53:288-292, 1994

3. Knuutila S, Slunga-Tallberg A, Ylinen K, El-Rifai W, Keinänen M: Äidin veren sikiöperäiset tumalliset punasolut kromosomipoikkeavuuksien prenataalidiagnostiikassa. Solubiologi (in Finnish), 13:33-37, 1994

4. Knuutila S, Larramendy ML, Elfving P, El-Rifai W, Miettinen A, Mitelman F (1995): Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney. Human Genetics, 95:149-156, 1995


5. El-Rifai W, Leisti J, Kähkönen M, Pietarinen A, Altherr MR, Knuutila S: A patient with Wolf-Hirschhorn syndrome originating from translocation t(4;8)(p16.3;q24.3)pat. Journal of Medical Genetics, 32:65-67, 1995

6. Slunga-Tallberg A, El-Rifai W, Keinänen M, Ylinen K, Kurki T, Klinger K, Ylikorkala O, Knuutila S: Maternal origin of nucleated erythrocytes in peripheral venous blood of pregnant women. Human Genetics, 96: 53-57, 1995

7. Larramendy M, El-Rifai W, Saarinen U, Alitalo R, Luomahaara S, Knuutila S: Myeloid lineage involvement in acute lymphoblastic leukemia - a morphology antibody chromosome study. Experimental Hematology, 23:1563-1567, 1995

8. El-Rifai W, Larramendy ML, Ruutu T, Knuutila S: Lymphoid involvement in a patient with acute myeloid leukemia: a direct phenotypic and genotypic study of single cells. Genes Chromosomes & Cancer, 15:34-37, 1996

9. El-Rifai W, Ruutu T, Vettenranta K, Temtamy S, Knuutila S: Minimal residual disease after allogeneic bone marrow transplantation for chronic myeloid leukaemia: a metaphase-FISH study. British Journal of Haematology, 92:365-369, 1996

10. Slunga-Tallberg A, El-Rifai W, Keinänen M, Ylinen K, Kurki T, Klinger K, Ylikorkala O, Larramendy ML, Knuutila S: Maternal origin of transferrin receptor positive cells in venous blood of pregnant women. Clinical Genetics, 49:196-199, 1996

11. El-Rifai W, Knuutila S: Fluorescent in situ hybridization on archival G-banded slides. Cell Genetics and Cytogenetics 73:322-324, 1996

12. Mertens F, Pålsson E, Lindstrand A, Toksvig-Larsen S, Knuutila S, Larramendy ML, El-Rifai W, Limon J, Mitelman F, Mandahl N: Evidence of somatic mutations in osteoarthritis. Human Genetics, 98:651-656, 1996

13. El-Rifai W, Sarlomo-Rikala M, Miettinen M, Knuutila S, Andersson LC (1996): DNA copy number losses in chromosome 14: an early change in gastrointestinal stromal tumors. Cancer Research, 56:3230-3233, 1996

14. Sulisalo T, Mäkitie O, Sistonen P, Ridanpää M, El-Rifai W, Ruuskanen O, de la Chapelle A, Kaitila I: Uniparental disomy in Cartilage-Hair Hypoplasia. European Journal of Human Genetics, 5: 35-42 , 1997

15. El-Rifai W, Ruutu T, Elonen E, Volin L, Knuutila S: Prognostic value of metaphase-fluorescence in situ hybridization in follow-up of patients with acute myeloid leukemia in remission. Blood, 89: 3330-3334, 1997

16. Billström R, Johansson B, Strömbeck B, El-Rifai W, Larramendy M, Olofsson T, Mitelman F, Knuutila S: Clonal CD5-positive B lymphocytes in myelodyplastic syndrome with systemic vasculitis and trisomy 8. Annals of Hematology, 74:37-40, 1997

17. El-Rifai W, Ruutu T, Vettenranta K, Elonen E, Saarinen UM, Volin L, Knuutila S: Follow-up of residual disease using metaphase-FISH in patients with acute lymphoblastic leukemia in remission. Leukemia, 11: 633-638, 1997

18. El-Rifai W, Elonen E, Larramendy M, Ruutu T, Knuutila S: Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia. Leukemia, 11: 958-963, 1997


19. Miettinen M, El-Rifai W, Sarlomo-Rikala M, Lahtinen T, Andersson LC, Knuutila S: Tumor size-related DNA copy number changes occur in solitaris fibrous tumors but not in hemangiopericytoma. Modern Pathology, 10:1194-1200, 1997

20. El-Rifai W, Larramendy M, Björqvist A-M, Hemmer S, Knuutila S: Optimization of comparative genomic hybridization using fluorochrome conjugated to dCTP and dUTP nucleotides. Laboratory Investigations, 77:699-700, 1997

21. Knuutila S, Armengol G, Björkqvist A-M, El-Rifai W, Larramendy ML, Monni O, Knuutila S: Comparative genomic hybridization study on pooled DNAs from tumors of one clinical-pathological entity. Cancer Genetics and Cytogenetics, 100: 25-30, 1998

22. El-Rifai W, Harper JC, Cummings OW, Hyytinen ER, Frierson HF Jr, Knuutila S, Powell SM: Consistent genetic alterations in xenografts of proximal stomach and gastro-esophageal junction adenocarcinomas. Cancer Research, 58: 34-37, 1998

23. Monni O, El-Rifai W, Larramendy ML, Knuutila S: Deletions and amplifications detected by comparative genomic hybridization in hematologic malignancies. Reviews in Clinical and Experimental Hematology 4: 56-69, 1998

24. Larramendy L, El-Rifai W, Knuutila S: Comparison of fluorescein isothiocyanate- and Texas red-conjugated nucleotides for direct labeling in comparative genomic hybridization. Cytometry, 31: 174-179, 1998

25. Kiuru-Kuhlefelt S, El-Rifai W, Sarlomo-Rikala M, Knuutila S Miettinen M: DNA gains and losses in alveolar soft part sarcoma: a comparative genomic hybridization study. Modern Pathology, 11: 227-231, 1998

26. Sarlomo-Rikala M, El-Rifai W, Lahtinen T, Andersson LC, Miettinen M, Knuutila S: Different patterns of DNA copy number changes in gastrointestinal stromal tumors, leiomyomas and schwannomas. Human Pathology, 29: 476-481, 1998

27. Knuutila S, Björkqvist A-M, Autio K, Tarkkanen M, Wolf M, Monni O, Szymanska J, Larramendy ML, Tapper J, Pere H, El-Rifai W, Hemmer S, Wasenius V-M, Vidgren V, Zhu Y (1998): DNA copy number amplifications in human neoplasms – a review of comparative genomic hybridization. American Journal of Pathology, 152:1107-1123, 1998

28. El-Rifai W, Sarlomo-Rikala M, Knuutila S, Miettinen M (1998): DNA copy number changes in development and progression in leiomyosarcomas of soft tissues. American Journal of Pathology, 153:985-990, 1998

29. Larramendy ML, El-Rifai W, Kokkola A, Puolakkainen P, Monni O, Salovaara R, Aarnio M, Knuutila S (1998): Comparative genomic hybridization reveals differences in DNA copy number changes between sporadic gastric carcinomas and gastric carcinomas from patients with hereditary nonpolyposis colorectal cancer. Cancer Genetics and Cytogenetics, 106: 62-65, 1998

30. Larramendy ML, Huhta T, Vettenranta K, El-Rifai W, Lundin J, Pakkala S, Saarinen-Pihkala UM, Knuutila S: Comparative genomic hybridization in childhood acute lymphoblastic leukemia. Leukemia, 12:1638-1644, 1998

31. El-Rifai W, Sarlomo-Rikala M, Andersson L, Miettinen M, Knuutila S: DNA copy number changes in gastrointestinal stromal tumors - A distinct genetic entity. Review. Ann Chir Gyn 87:287-290, 1998


32. Plass C, Yu F, Yu L, El-Rifai W, Strout MP, Knuutila S, Held WA, Bloomfield CD, Caligiuri MA: Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene. Oncogene, 18:3159-3165, 1999

33. Zhu Y, Monni O, El-Rifai W, Siitonen SM, Vilpo L, Vilpo J, Knuutila S: Discontinuous deletions at chromosome 11q23 in B-cell chronic lymphocytic leukemia. Leukemia, 13:708-712, 1999

34. El-Rifai W, Tarmo L, Hemmer S, Försti A, Pedersen N, Lichtenstein P, Ahlbom A, Söderberg M, Knuutila S, Hemminki K: DNA copy number losses at 1p32-pter in monozygotic twins concordant for breast cancer. Cancer Genetics and Cytogenetics, 112:169-172, 1999

35. Knuutila S, Autio K, Björkqvist A-M, Aalto Y, El-Rifai W, Hemmer S, Huhta T, Kiuru-Kuhlefelt S, Larramendy ML, Lushnikova T, Monni O, Pere H, Tapper J, Tarkkanen M, Varis A, Wasenius V-M, Wolf M, Zhu Y: DNA copy number losses in human neoplasms. American Journal of Pathology, 155:683-694 , 1999

36. El-Rifai W, Kamel D, Larramendy M.L., Shoman S, Gad Y, Baithun S, El-Awady M, Eissa S, Khaled H, Soloneski S, Sheaff M, and Knuutila S: DNA copy number changes in schistosoma-associated and non-schistosoma-associated bladder cancer. American Journal of Pathology, 156: 871-878, 2000

37. El-Rifai W, Sarlomo-Rikala, Andersson L, Miettinen M, and Knuutila S: High-resolution deletion mapping of chromosome 14 in stromal tumors of the gastrointestinal tract suggests two distinct tumor suppressor loci. Genes Chromosomes & Cancer, 27:387-391, 2000

38. Kettunen E, El-Rifai W, Björkqvist A-M, Wolff H, Karjalainen A, Anttila S, Mattson K, Husgafvel-Pursiainen K, Knuutila S: A broad amplification pattern at 3q in squamous cell lung cancer- a fluorescent in situ hybridization study. Cancer Genetics and Cytogenetics 117:66-70, 2000

39. El-Rifai W, Sarlomo-Rikala M, Andersson LC, Knuutila S, Miettinen M: DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance. Cancer Research 60:3899-3903, 2000

40. Wolf M, El-Rifai W, Tarkkanen M, Kononen J, Serra M, Eriksen EF, Elomaa I, Kallioniemi A, Kallioniemi O-P, and Knuutila S: Molecular profiling of human osteosarcoma cell lines by cDNA microarrays. Cancer Genet Cytogenet 123:128-132, 2000

41. Kettunen E, Nissen A-M, Ollikainen T, Taavitsainen M, Tapper J, Mattson K, Linnainmaa K, Knnutila S, El-Rifai W: Gene expression profiling of malignant mesothelioma cell lines-cDNA array study. International Journal of Cancer, 91:492-496, 2001

42. El-Rifai W, Frierson HF Jr, Harper JC, Powell SM, Knuutila S: Expression profiling of gastric adenocarcinoma using cDNA array. International Journal of Cancer, 92, 832-838, 2001

43. Tapper J, Kettunen E, El-Rifai W, Seppälä M, Andersson LC & Knuutila S: Changes in gene expression during progression of ovarian carcinoma. Cancer Genet and Cytogenet, 128:1-6, 2001

44. Kiuru-Kuhlefelt S, El-Rifai W, Fanfurg-Smith J, Kere J, Miettinen M & Knuutila S: Concomitant DNA copy number amplification at 17q and 22q is pathognomonic of dermatofibrosarcoma protuberans. Cytogenet and Cell Genet, 92:192-195, 2001

45. El-Rifai W, Frierson HF, Moskaluk CA, Frierson HF, Harper, JC, Petroni G, Bissonette E, Jones D, Knuutila S, and Powell SM (2001): Genetic Differences between adenocarcinomas arising in Barrett’s esophagus and gastric mucosa. Gastroenterology, 121:592-598, 2001


46. Aalto Y, El-Rifai W, Vilpo L, Ollila J, Nagy B, Vihinen M, Vilpo J & Knuutila S: Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion. Leukemia, 15:1721-1728, 2001

47. El-Rifai W, Rutherford S, Knuutila S, Frierson Jr HF, Moskaluk CA: Novel DNA copy number losses in chromosome 12q12-q13 in adenoid cystic carcinoma. Neoplasia, 3:173-178, 2001

48. Ascaño JJ, Frierson HF Jr., Moskaluk CA, Harper J, Roviello F, Vindigni C, El-Rifai W, Tosi P, Powell SM: Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer. Modern Pathology, 14:942-949, 2001

49. Shuber AP, Ascaño J, Boynton KA, Mitchell A, Frierson HF Jr., El-Rifai W, Powell SM: Accurate non-invasive detection of H. pylori DNA before and after treatment. J Clin Microbiol 40:262-264, 2002

50. El-Rifai W, Powell SM: Molecular Biology of Gastric Cancer, Review. Semin Radiat Oncol, 12:128-140, 2002

51. Miettinen M, El-Rifai W, Sobin LH, O’Leary T, Lasota J: Evaluation of malignancy and prognosis of gastrointestinal stromal tumors- A review. Human Pathology 33:478-483, 2002

52. DeMatteo RP, Heinrich M, El-Rifai W, Demetri G: Clinical management of gastrointestinal stromal tumors: Before and after STI-571. Human Pathology 33:466-477, 2002

53. El-Rifai W and Powell SM: Molecular and biologic basis of upper GI malignancy gastric carcinoma- A review. Surgical Oncology Clinics of North America 12:128-140, 2002

54. Varis A, Wolf M, Monni O, Vakkari M-L, Kokkola A, Moskaluk M, Frierson H Jr., Powell SM, Knuutila S, Kallioniemi A, El-Rifai W: Targets of gene amplification and overexpression at 17q in gastric cancer. Cancer Research 62:2625-2629, 2002

55. El-Rifai W, Smith M, Lee G, Beckler A, Carl G, Moskaluk C, Frierson H, Powell SM: Gastric Cancers Overexpress DARPP-32 and a novel isoform (t-DARPP). Cancer Research, 62:4061-4064, 2002

56. El-Rifai W, Moskaluk C, Abdrabbo MK, Harper J, Yoshida C, Riggins GJ, Frierson HFJr, Powell S: Gastric cancers overexpress S100A calcium binding proteins. Cancer Research 62:6823-6826, 2002

57. Deng D, El-Rifai W, Ji J, Zhu B, Trampont P, Li J, Smith MF, Powell S: Hypermethylation of metallothionein-3 CpG island in gastric carcinoma. Carcinogenesis, 24:25-29, 2003

58. Beckler A, Moskaluk CA, Zaika A, Hampton G, Powell S, Frierson HFJr, El-Rifai W: Overexpression of DARPP-32 in common adenocarcinomas. Cancer, 98:1547-1551, 2003

59. Berr SS, Roche JK, El-Rifai W, Smith MFJr, Powell SM: Magnetic Resonance Imaging of gastric cancer in TFF1 knockout mice. Magnetic Resonance in Medicine. 49:1033-1066, 2003

60. Beckler A, Roche JK, Harper JC, Petroni G, Frierson HFF, Moskaluk, CA, El-Rifai W, Powell SM: Dysregulation of TFF1 gene expression is common in human gastric cancer. Cancer, 98:2184-91, 2003

61. Koon N, Schneider-Stock R, Sarlomo-Rikala M, Lasota J, Smoklin M, Petroni G, Zaika A, Boltze C, Meyer F, Andersson L, Knuutila S, Miettinen M, El-Rifai W: Molecular targets for tumor progression of gastrointestinal stromal tumors. Gut. 53: 235-240, 2004


62. Varis A, Zaika A, Puolakkainen P, Nagy B, Kokkola A, Väyrynen A, Kärkkäinen K, Moskaluk M, Knuutila S, El-Rifai W: Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. Int J Cancer. 109:548-553, 2004

63. Koon N, Zaika A, Moskaluk C, Frierson HF Jr, Knuutila S, Powell S, El-Rifai W: Clustering of molecular alterations in GEJ carcinomas. Neoplasia 6:143-149, 2004

64. Gutiérrez MI, Siraj AK, Khaled H, El-Rifai W, Bhatia K: CpG island methylation in Schistosoma Associated and Non-Schistosoma Associated Bladder Cancer. Modern Pathology. 17:1268-1274, 2004

65. Wagner KW, Sapinoso LM, El-Rifai W, Frierson HFF, Hoffmann F, Hampton G, Deveraux QL: Downregulation of the ubiquitin conjugating enzyme UbcH10 by RNA interference sensitizes cancer cells to TRAIL/DR5-induced apoptosis. Oncogene. 23:6621-6629, 2004

66. Tomkova K, Belkhiri A, El-Rifai W, Zaika A: p73 isoforms can induce TCF-dependent transcription in gastrointestinal cells. Cancer Research. 64:6390-6393, 2004

67. Johnson AH, Frierson HFJr, Zaika A, Powell SM, Roche J, Crowe SE, Moskaluk CA, El-Rifai W: Expression of tight junction protein Claudin 7 is an early event in gastric tumorigenesis. Am J Pathology, 167:577-584, 2005

68. Belkhiri A, Zaika A, Pidkovka N, Moskaluk CA, El-Rifai W: DARPP-32: A novel anti-apoptotic cancer gene in upper gastrointestinal tumors. Cancer Research, 65:6583-6592, 2005

69. Lee OJ, Schneider-Stock R, McChesney P, El-Rifai W: Loss of expression and hypermethylation of GPx3 in Barrett’s tumorigenesis. Neoplasia, 7:854-861, 2005

70. McChesney P, Aiyer S, Lee OJ, Zaika A, Moskaluk C, Li R, El-Rifai W: COBRA1: A novel transcription factor regulator in upper gastrointestinal carcinomas. Cancer Research, 66:1346-1353, 2006

71. Wu Z, Siadaty MS, Riddick G, Frierson HF Jr, Lee JK, Knuutila S, Hampton G, El-Rifai W and D. Theodorescu: A novel method for gene expression mapping of metastatic competence in human bladder cancer. Neoplasia, 8:181-189, 2006

72. Tomkova K, El-Rifai W, Vilgelm A, Kelly MC, Wang TC, Zaika AI: The gastrin gene promoter is regulated by p73 isoforms in tumor cells. Oncogene, 25(44):6032-6036, 2006

73. Zaika AI, El-Rifai W: The role of p53 protein family in gastrointestinal malignancies. Cell Death Differ, 13: 935-940, 2006

74. Maqani N, Belkhiri A, Moskaluk CA, Knuutila S, Dar AA, El-Rifai W: Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas. Mol Cancer Res, 4: 449-455, 2006

75. Lee OJ, Hong SM, Razvi MH, Peng D, Powell SM, Smoklin M, Moskaluk CA, El-Rifai W: Expression of calcium-binding proteins S100A2 and S100A4 in Barrett's adenocarcinomas. Neoplasia, 8:843-50, 2006

76. Kuester D, Dar AA, Moskaluk CC, Krueger S, Meyer F, Hartig R, Stolte M, Malfertheiner P, Lippert H, Roessner A, El-Rifai W, Schneider-Stock R: Early involvement of death-associated protein kinase promoter hypermethylation in the carcinogenesis of Barrett's esophageal adenocarcinoma and its association with clinical progression. Neoplasia, 9:236-45, 2007

77. Razvi M, Peng D, Powell S, Moskaluk C, Washington K, El-Rifai W: Serial analysis of gene expression identifies novel oncogenomic transcriptional hot spots in Barrett’s adenocarcinomas. Genes Chromosomes and Cancer, 46:914-928, 2007

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17401463&query_hl=20&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17401463&query_hl=20&itool=pubmed_docsum


78. Belkhiri A, Zaika A, Kelley M, El-Rifai W: t-Darpp promotes cancer cell survival by upregulation of Bcl2 through Akt-dependent mechanism. Cancer Res. 68(2):395-403, 2008

79. Peng D, Sheta EA, Powell S, Moskaluk CA, Washington K, Goldknopf IL, El-Rifai W: Alterations in Barrett’s Related Adenocarcinomas: A Proteomic Approach. Int J Cancer. 15;122(6):1303-10, 2008

80. Vilgelm A, Wei J, Piazeuleo MB, Washington MK, Prassolov V, El-Rifai W, Zaika A: DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function. Oncogene. 27(15):2170-6, 2008

81. Dar AA, Zaika A, Piazuelo MB, Correa P, Koyama T, Belkhiri A, Washington K, Castells A, Pera M, El-Rifai W: Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer, 112:1688-1698, 2008

82. Wei J, O’Brien D. Vilgelm A, Piazuelo MB, Correa P, El-Rifai W, Peek R, and Zaika A: Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology. 134(5):1412-23, 2008

83. Belkhiri A, Dar A, Peng D, Razvi M, Arteaga C, El-Rifai W: Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells. Clin Cancer Res. 14(14):4564-71, 2008

84. Senapati S, Chaturvedi P, Sharma P, Venkatraman G, Meza JL, El-Rifai W, Roy HK and Batra SK: Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer. Br J Cancer, 99: 949-956, 2008

85. Lee W, Belkhiri A, Lockhart CA, Merchant N, Glaeser H, Harris EI, Washington K, Brunt EM, Zaika A, Kim RB, El-Rifai W: Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Cancer Res. 68(24):10315-23, 2008

86. Vilgelm A, El-Rifai W, and Zaika A: Therapeutic prospects for p73 and p63: Rising from the shadow of p53. Drug Resist Update. 11(4-5):152-63, 2008

87. Dar AA, Belkhiri A, Jeffrey Ecsedy, Zaika A, El-Rifai W: Aurora Kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells. Cancer Res. 68(21):8998-9004, 2008

88. Dar AA, Belkhiri A, Zaika, El-Rifai W: Aurora Kinase A regulates GSK-3b in gastric cancer cells. Oncogene, 28(6):866-75. 2009

89. Kuester D, El-Rifai W, Peng D, Ruemmele P, Kroeckel I, Peters B, Moskaluk CC, Stolte M, Mönkemüller K, Meyer F, Schulz HU, Hartmann A, Roessner A, Schneider-Stock R: Silencing of MGMT expression by promoter hypermethylation in the metaplasia-dysplasia-carcinoma sequence of Barrett’s esophagus. Cancer Lett. 275(1):117-26. 2009

90. Smith SC, Nicholson B, McRoberts K, Nitz M, Frierson HJr, Smolkin M, Hampton G, El-Rifai W, Theodorescu D: Profiling bladder cancer organ site specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination. Am J Pathol, 174(2):371-9, 2009

91. Peng D, Razvi M, Chen H, Washington M, Roessner A, Schneider-Stock R, El-Rifai W: DNA hypermethylation regulates the expression of members of the Mu-class Glutathione-S-Transferases and Glutathione Peroxidases in Barrett’s adenocarcinoma. Gut. 58(1):5-15, 2009

92. Dar AA, Goff W. L, Majid S, Berlin J, El-Rifai W: Aurora Kinases' Inhibitors - The Rising Stars in Cancer Therapeutics? Mol Cancer Therap, 9:268-278, 2010

93. Mukherjee K, Chakravarthy AB, Goff LW, El-Rifai W: Esophageal Adenocarcinoma: Treatment Modlaities in the ERA of Targeted Therapy. Digestive Diseases and Sciences, 55(12):3304-14, 2010


94. Mukherjee K, Peng D, Brifkani Z, Lee O-J, Castells A, Pera M, Koyama T, Koehler EAS, , Frank L. Revetta FL, Washington MK, Belkhiri A, El-Rifai W: DARPP-32 is Over-expressed in Early Stages of Gastric Tumorigenesis. Surgery, 148:354-63, 2010

95. Vilgelm AE, Hong SM, Washington MK, Wei J, Chen H, El-Rifai W, Zaika A: Characterization of DeltaNp73 expression and regulation in gastric and esophageal tumors. Oncogene, 28;29(43):5861-8, 2010

96. Wei J, Nagy TA, Vilgelm A, Zaika E, Ogden SR, Romero-Gallo J, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A: Regulation of p53 Tumor Suppressor by Helicobacter pylori in Gastric Epithelial Cells. Gastroenterology, 139(4):1333-43, 2010

97. Mukherjee K, Peng D, Brifkani Z, Belkhiri A, Pera M, Koyama T, Koehler EA, Revetta FL, Washington MK, El-Rifai W: Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis. Surgery, 48:354-63, 2010

98. Soutto M, Peng D, Razvi M, Ruemmele P, Hartmann A, Roessner A, Schneider-Stock R, El-Rifai W. Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas. Cancer 1;116(17):4033-42, 2010

99. Vangamudi B, Peng DF, Cai Q, El-Rifai W, Zheng W, Belkhiri A: t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer. Mol Cancer, 13;9:240, 2010

100. Schneider BG, Peng DF, Camargo MC, Piazuelo MB, Sicinschi LA, Mera R, Romero-Gallo J, Delgado AG, Bravo LE, Wilson KT, Peek RM Jr, Correa P, El-Rifai W: Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer. 127(11):2588-97, 2010

101. Soutto SM, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe SE, Zaika A, Correa P, Peek RM Jr, El-Rifai W. Loss of TFF1 is associated with activation of

NF-B–mediated inflammation and gastric neoplasia in mice and humans. Journal Clinical Investigation, 121:1753-67, 2011

102. Vangamudi B, Zhu S, Soutto M, Belkhiri A, El-Rifai W. Regulation of b-catenin by t-DARPP in upper gastrointestinal cancer cells. Molecular Cancer, Mar 29;10:32, 2011

103. Ueda Y, Hajri T, Peng D, Marks-Shulman PA, Tamboli RA, Shukrallah B, Saliba J, Jabbour K, El-Rifai W, Abumrad NA, Abumrad NN. Reduction of 8-iso-Prostaglandin F2α in the First Week After Roux-en-Y Gastric Bypass Surgery. Obesity (Silver Spring), 19(8):1663-8, 2011

104. Peng D, Lu T-L, Jiang A, Washington MK, Moskaluk CA, Schneider-Stock R, El-Rifai W. Location-specific Epigenetic Regulation of the Metallothionein 3 Gene in Esophageal Adenocarcinomas. PlosOne, 6(7):e22009, 2011

105. Zaika E, Wei J, Yin D, Andl C, Moll U, El-Rifai W, Zaika A. p73 protein regulates DNA damage repair. FASEB, in press, 2011

106. Rau-TT, Rogler-A, Frischauf-M, Jung-A, Konturek-PC, Dimmler-A, Faller-G, El-Rifai-W, Hartmann-A, Schneider-Stock-R*, Voll-RE. Methylation dependent activation of CDX1 through NF-kB - a link from inflammation to intestinal metaplasia in the human stomach. J Pathol, in press, 2011

107. Williams CS, Zhang B, Smith JJ, Jayagopal A, Barrett CW, Pino C, Russ P, Presley SH, Peng D, Rosenblatt DO, Haselton FR, Yang JL, Washington MK, Chen X, Eschrich S, Yeatman TJ, El-Rifai W,

http://preview.ncbi.nlm.nih.gov/pubmed/20676143




http://www.ncbi.nlm.nih.gov/pubmed/20580047

http://www.ncbi.nlm.nih.gov/pubmed/20580047




Beauchamp RD, and Chang MS. BVES regulates epithelial-mesenchymal phenotype and is silenced via promoter methylation in human epithelial malignancy. Journal Clinical Investigation, 121(10):4056-69, 2011

108. Zhu S, Belkhiri A, El-Rifai W. DARPP-32-mediated EGFR protein stability leads to gefitinib resistance in gastric cancer. Gastroenterology, 141(5):1738-1748, 2011

109. Peng D, Belkhiri A, HU TL, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W. Glutathione Peroxidase 7 Protects Against Oxidative DNA Damage in Oesophageal Cells. GUT, in press, 2011

110. Lim J, Jang G, Kang S, Lee G, Nga DT, Phuong DT, Kim H, El-Rifai W, Ruley HE, Jo D. Cell permeable NM23 blocks the maintenance and progression of established pulmonary metastasis. Cancer Research, in press, 2011

BOOK CHAPTERS AND BOOKS EDITED 1. El-Rifai W, Knuutila S: Microarray Technology. In Colorectal Cancer Methods and Protocols.

Methods in Molecular Medicine Series. Edited by Powell S. Humana Press Inc., Totowa, NJ, USA, 2001

2. El-Rifai W, Knuutila S: Comparative Genomic Hybridization Technique. In Colorectal Cancer Methods and Protocols. Methods in Molecular Medicine Series. Edited by Powell S. Humana Press Inc., Totowa, NJ, USA, 2001

ABSTRACTS 1. Slunga-Tallberg A, El-Rifai W, Keinänen M, Ylinen K, Kurki T, Klinger K, Ylikorkala O, Knuutila S:

Maternal origin of nucleated erythrocytes in peripheral venous blood of pregnant women. European Community Concerted Action - Automation Molecular Cytogenetic Analyses, Second Plenary Workshop, November 9-13 1994; Galway, Ireland

2. El-Rifai W, Sarlomo-Rikama M, Miettinen M, Andersson L, Knuutila S: DNA gains and losses in gastrointestinal stromal tumours: A comparative genomic hybridization study. European Conference on Comparative Genomic Hybridization, Feb 29 - Mar 2, 1996; Semmering, Austria

3. Knuutila S, Armengol G, Björkqvist A-M, El-Rifai W, Larramendy ML, Monni O, Szymanska J: Comparative genomic hybridization study on pooled DNAs from tumors of one clinical-pathological entity. IV. Plenary Workshop of the European Concerted Action "Automation of Molecular Cytogenetic Analyses"; November 7-9, 1996; Noordwijk, The Netherlands

4. El-Rifai W, Sarlomo-Rikala M, Lahtinen T, Miettinen M, Andersson LC, Knuutila S: DNA gains and losses in gastrointestinal tract stromal tumors, leiomyomas, and leiomyosarcomas using comparative genomic hybridization. Seventh International Workshop on Chromosomes and Solid Tumors; January 20-22, 1997, Tucson, AZ, USA

5. Nennesmo I, El-Rifai W, Malm G, Marcus C, Knuutila S: Neuropathology and localization of donor cells in the brain of a bone marrow transplanted boy with adrenoleukodystrophy. Nobel




Symposium, Correction of Genetic Diseases by Transplantation, Nobel Forum, Karolinska Institute; June 2-3, 1997; Stockholm, Sweden

6. El-Rifai W, Ruutu T, Elonen E, Volin L, Knuutila S: Evidence of prognostic value of metaphase-fluorescence in situ hybridization in follow-up of patients with acute myeloid leukemia in remission. 28th Nordic Spring Meeting of Hematology; May 22-24, 1997; Helsinki, Finland

7. El-Rifai W, Elonen E, Larramendy M, Ruutu T, Knuutila S: Comparative genomic hybridization and karyotype analysis in the study of refractory acute myeloid leukemia. 28th Nordic Spring Meeting of Hematology; May 22-24, 1997; Helsinki, Finland

8. El-Rifai W, Ruutu T, Saarinen U, Elonen E, Vettenranta K, Volin L, Knuutila S: Clinical relevance of metaphase-fluorescence in situ hybridization in follow-up for minimal residual disease in patients with leukemia in remission. XIVth Meeting of the International Society of Haematology, European & African Division; Aug 30 - Sept 4, 1997; Stockholm International Fairs; Stockholm, Sweden

9. Larramendy M, El-Rifai W, Elonen E, Ruutu T, Knuutila S: Changes in DNA copy number and chromosomal breakpoints in refractory acute myeloid leukemia. XIVth Meeting of the International Society of Haematology, European & African Division; Aug 30 - Sept 4, 1997; Stockholm International Fairs; Stockholm, Sweden

10. Plass C, Yu F, Yu L, Smiraglia D, El-Rifai W, Knuutila S, Strout M, Held W, Caligiuri M: Genome scanning for aberrant methylation in acute myeloid leukemia. 89th Annual Meeting of the American Association for Cancer Research; Mar 28 - Apr 1, 1998; New Orleans, LA, USA

11. Amal M, El-Rifai W, Kamel A, Abdel-Meguid N: Comparison of G-banding and FISH for laboratory evaluation of sex chromosomes mosaicism. 30th Annual meeting of the European Society of Human Genetics; May 10-13, 1998; Lisbon, Portugal

12. Kiuru-Kuhlefelt S, El-Rifai W, Sarlomo-Rikala M, Knuutila S, Miettinen M: DNA gains and losses in alveolar soft part sarcoma: comparative genomic hybridization study. 30th Annual meeting of the European Society of Human Genetics; May 10-13, 1998; Lisbon, Portugal

13. El-Rifai W, Sarlomo-Rikala M, Miettinen M, and Knuutila S: DNA Copy Number Changes in Development and Progression in Leiomyosarcomas of Soft Tissues. XV Meeting of the European Association for Cancer Research; August 15-19, 1998; Stockholm, Sweden

14. Larramendy ML, Huhta T, Vettenranta K, El-Rifai W, Rantala-Saarinen U, Knuutila S: A comparative genomic hybridization study on 72 consecutive patients with childhood acute lymphoblastic leukemia. 18th International Congress of Genetics; August 16-18, 1998; Beijing, China

15. Zhu Y, Monni O, El-Rifai W, Siitonen SM, Vilpo L, Vilpo J, Knuutila S: Discontinuous Deletions at Chromosome 11q23 in B-Cell Chronic Lymphocytic Leukemia. Cold Spring Harbor Meeting “Cancer Genetics & Tumor Suppressor Genes”; August 19-23, 1998; New York, USA

16. El-Rifai W, Sarlomo-Rikala M, Miettinen M, and Knuutila S: DNA Copy Number Changes in Development and Progression in Leiomyosarcomas of Soft Tissues. 13th International Chromosome Conference; September 9-12, 1998; Ancona, Italy

17. El-Rifai W, Sarlomo-Rikala M, Miettinen M, Knuutila S, Andersson L: DNA copy number changes in GIST. First International symposium on GIST; September 25-26, 1998; Helsinki, Finland


18. Wolf M, El-Rifai W, Tarkkanen M, Kononen J, Eriksen EF, Serra M, Elomaa I, Kallioniemi O-P, and Knuutila S: cDNA microarray analysis defines a gene expression profile in osteosarcomas. 90th Annual meeting of the American Association for Cancer Research; April 10-14, 1999; Philadelphia, PA, USA

19. El-Rifai W, Shoman S, Larramendy M, Kamel D, Gad Y, Baithun S, El-Awady M, Eissa S, Khaled H, Hamza R, Sheaff M, and Knuutila S: DNA copy number changes in non-schistosomiasis and schistosomiasis associated bladder cancer. 31st Annual Meeting of the European Society of Human Genetics; May 29 - June 2, 1999; Geneva, Switzerland

20. Meguid N, Mohamed A, El-Rifai W, Kamel AK, and El-Ruby MO: Complex chromosomal rearrangement in a child with multiple congenital abnormalities: identification by chromosome panting. 31st Annual Meeting of the European Society of Human Genetics; May 29 - June 2, 1999; Geneva, Switzerland

21. Kettunen E, El-Rifai W, Björkqvist A-M, Wolff H, Karjalainen A, Anttila S, Mattson K, Husgafvel-Pursiainen K, Knuutila S: An interphase-FISH study on squamous cell lung cancer reveals a wide amplification pattern of DNA sequence at 3q25-q27. Second European Cytogenetics Conference; July 3-6, 1999; Vienna, Austria

22. El-Rifai W, Sarlomo-Rikala M, Miettinen M, Knuutila S: Prognostic DNA sequence copy number changes in stromal tumors of the gastrointestinal tract. The Eight International Workshop on Solid Tumors; Jan 30 - Feb 1, 2000; Tucson, AZ, USA

23. Kettunen E, El-Rifai W, Nissen A-M, Ollikainen T, Taavitsainen M, Tapper J, Mattson K, Linnainmaa K, Knnutila S: Gene expression profiling of malignant mesothelioma cell lines-cDNA array study. The Eight International Workshop on Solid Tumors; Jan 30 - Feb 1, 2000; Tucson, AZ, USA

24. Wolf M, El-Rifai W, Tarkkanen M, Kononen J, Eriksen E, Serra M, Elomaa I, Kallioniemi A, Kallioniemi O-P, Knuutila S: cDNA microarray analysis on human osteosarcoma cell lines. The Eight International Workshop on Solid Tumors; Jan 30 - Feb 1, 2000; Tucson, AZ, USA

25. Allto Y, El-Rifai W, Vilpo L, Vilpo J, and Knuutila S: Gene expression profiling in chronic lymphocytic leukemia. The First Euro Conference in Quantitative Molecular Cytogenetics; April 13-15, 2000; Bari, Italy

26. Niini T, El-Rifai W, Larramendy ML, Elonen E, and Knuutila S: Gene expression profiling in acute myeloid leukemia using cDNA array technology. The First Euro Conference in Quantitative Molecular Cytogenetics; April 13-15; Bari, Italy

27. El-Rifai W, Frierson HF, Harper JC, Powell SM, and Knuutila S: Expression profiling in proximal stomach and gastro-esophageal junction adenocarcinomas using cDNA arrays technology. The First Euro Conference in Quantitative Molecular Cytogenetics; April 13-15, 2000; Bari, Italy

28. El-Rifai W, Frierson HF, Harper JC, Powell SM, and Knuutila S: Expression profiling in proximal stomach and gastro-esophageal junction adenocarcinomas using cDNA arrays technology. The European Human Genetics Conference 2000; May 27-30, 2000; Amsterdam, Netherlands

29. Rutherford S, Frierson HF, El-Rifai W, Knuutila S, Moskaluk CA: Identification of Chromosome 12q as a Region of Deletion in Salivary Adenoid Cystic Carcinoma. American Association for Cancer Research, 92nd Annual Meeting; March 24-28, 2001; New Orleans, LA, USA

http://aacr01.agora.com/planner/displayabstract.asp?presentationid=13157

http://aacr01.agora.com/planner/displayabstract.asp?presentationid=13157


30. El-Rifai W: Molecular Changes in GISTs. National Cancer Institute, Gastrointestinal Stromal Tumors Workshop; April 2-3, 2001; Bethesda, MD, USA

31. Varis A, Monni O, Wolf M, Kallioniemi A, Knuutila S, and El-Rifai W: Gene Amplification and overexpression at 17q in Gastric Cancer. 8th European Workshop on Cytogenetics and Molecular Genetics of Human Solid Tumors; September 12-15, 2002; Barcelona, Spain

32. Koon N, Moskaluk C, Knuutila S, Kallioniemi A, Powell S, Frierson H, and El-Rifai W: Target genes at 17q in gastric cancer. Digestive Disease Week; May 17-22, 2003; Orlando, FL, USA

33. Koon N, Moskaluk C, Powell SM, Knuutila S, Kallioniemi A, El-Rifai W: Unraveling the genome in upper gastrointestinal carcinomas. XXXV Nordic Meeting of Gastroenterology; June 11-14, 2003; Helsinki, Finland

34. El-Rifai W: The 17q amplicon in gastric cancer. AACR 94th Annual Meeting, The New Washington Convention Center; July 11-14, 2003; Washington, DC, USA

35. Berr SS, Roche JK, El-Rifai W, Smith MF: MRI of Gastric Cancers in TFF1 knockout mice. International Society of Magnetic Resonance in Medicine 11th annual meeting; May 2003; Toronto, Canada

36. El-Rifai W: Molecular Targets in upper gastrointestinal carcinomas. 8th World Congress on Advances in Oncology; 16-18, 2003; Crete, Greece

37. Zaika AI, Pokvoka N, Crowe S, Roche J, Berr S, Smith MF, Moskaluk C, Powell S, El-Rifai W: The TFF1 knockout mice: An opportunity to study genetic alterations of early gastric tumorigenesis. Digestive Disease Week 2004; May 15-20, 2004; New Orleans, LA, USA

38. Zaika AI, Petrenko O, Moll U, Powell S, Frierson HF, El-Rifai W: DeltaNp73 is a potent oncogene overexpressed in upper gastrointestinal adenocarcinomas. Digestive Disease Week 2004; May 15-20, 2004; New Orleans, LA, USA

39. Sankpal N, Zaika AI, Frierson HF, Powell S, El-Rifai W: Dysregulation of calcium signaling molecules in gastric cancer. Digestive Disease Week 2004; May 15-20, 2004; New Orleans, LA, USA

40. Zaika AI, Varis A, Knuutila S, Moskaluk C, El-Rifai W: Gastric cancer: differential expression of genes inside the ERBB2 amplicon. Digestive Disease Week 2004; May 15-20, 2004; New Orleans, LA, USA

41. Koon N, Zaika AI, Moskaluk C, Powell S, Frierson HF, El-Rifai W: Clustering of overexpressed genes in chromosomal domains in GEJ carcinomas. Digestive Disease Week 2004; May 15-20, 2004; New Orleans, LA, USA

42. Sharma S, Sheta E, Goldknopf I, Moskaluk C, Powell S, Zaika AI, El-Rifai W: Differences between proximal and distal upper gastrointestinal adenocarcinomas: Proteomic approach. Digestive Disease Week 2004; May 15-20, 2004; New Orleans, LA, USA

43. Hassan A, Zaika AI, Schneider-Stock R, Petroni G, Miettinen M, El-Rifai W: Prognostic Molecular Biomarkers in GISTs. Digestive Disease Week 2004; May 15-20, 2004; New Orleans, LA, USA

44. El-Rifai W: DARPP-32 from neurosignaling to cancer. 9th World Congress on Advances in Oncology; 14-16, 2004; Crete, Greece

45. El-Rifai W: The TFF1 mouse model: an opportunity to study early events in gastric tumorigenesis. Gastrointestinal Cancer Symposium; January 26-28, 2005; Miami, FL, USA


46. Belkhiri A, Pidkovka N, Zaika AI, El-Rifai W: Anti-apoptotic role of DARPP-32 in gastric cancer. AACR 96th Annual Meeting, Anaheim Convention Center; April 16-20, 2005; Anaheim, CA, USA

47. Zaika AI, Tomakova K, El-Rifai W: The role of p73 in gastric tumorigenesis. AACR 96th Annual Meeting, Anaheim Convention Center; April 16-20, 2005; Anaheim, CA, USA

48. McChesney P, Lee O-J, Aiyer S, Li R, El-Rifai W: Downregulation of TFF1 in gastric adenocarcinomas by COBRA1. AACR 96th Annual Meeting. Anaheim Convention Center; April 16-20, 2005; Anaheim, CA, USA

49. Maqani N, Moskaluk C, El-Rifai W: Expression of tight junction protein claudin-7 is an early event in gastric tumorigenesis. AACR 96th Annual Meeting, Anaheim Convention Center; April 16-20, 2005; Anaheim, CA, USA

50. Belkhiri A and El-Rifai W: DARPP-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas. 2006 Gastrointestinal Cancer Symposium; January 26-28, 2006; San Francisco, CA, USA

51. Lee OJ, McChesney P, Moskaluk C, El-Rifai W: Loss of expression and DNA methylation of GPx3 in Barrett’s Tumorigenesis. 2006 Gastrointestinal Cancer Symposium; January 26-28, 2006; San Francisco, CA, USA

52. Belkhiri A, Dar A, Zaika AI, El-Rifai W: t-DARPP suppresses apoptosis through upregulation of BCL2 in upper gastrointestinal carcinomas. AACR 97th Annual Meeting., Washington Convention Center; April 1-5, 2006; Washington, DC, USA

53. Wei J, Tomkova K, El-Rifai W, Zaika AI: The gastrin promoter is regulated by p73 isoforms in tumor cells. AACR 97th Annual Meeting, Washington Convention Center; April 1-5, 2006; Washington, DC, USA

54. McChesney P, Razvi M, Li R, Moskaluk C, Zaika AI, El-Rifai W: Cobra1: A novel regulator of TFF1 transcription in upper gastrointestinal adenocarcinomas. Digestive Disease Week 2006; May 21-24, 2006; Los Angeles, CA, USA

55. Lee O-J, Hong SM, Belkhiri A, Moskaluk C, El-Rifai W: Overexpresssion of calcium binding proteins S10A4 in Barrett’s tumorigenesis. Digestive Disease Week 2006; May 21-24, 2006; Los Angeles, CA, USA

56. Tomkova K, El-Rifai W, Zaika AI: Involvement of p73 protein in gastrointestinal tumorigenesis. Digestive Disease Week 2006; May 21-24, 2006; Los Angeles, CA, USA

57. Belkhiri A, Dar A, El-Rifai W: t-Darpp suppresses apoptosis through up-regulation of Bcl2 in gastrointestinal adenocarcinomas. Digestive Disease Week 2006; May 21-24, 2006; Los Angeles, CA, USA

58. Schneider-Stock R, Kuester D, Dar A, Veith M, Peitz U, Peters B, Moskaluk C, Meyer F, Stolte M, Malfertheiner P, Lippert H, Roessner A, El-Rifai W: MGMT promoter hypermethylation in Barrett’s tumorigenesis. Digestive Disease Week 2006; May 21-24, 2006; Los Angeles, CA, USA

59. Kuester D, El-Rifai W, Guenther T, Hartmann A, Tannapfel A, Myer F, Bohr U, Pross M, Guenther M, Bataille F, Ruemmele P, Silver A, Malfertheiner P, Lippert H, Roessner A, Schneider-Stock R: Aberrant promoter methylation pattern in ulcerative colitis associated adenocarcinomas. Digestive Disease Week 2006; May 21-24, 2006; Los Angeles, CA, USA


60. Kuester D, Koenig B, Lippert H, Peters B, Guenther T, El-Rifai W, Ruemmele P, Roessner A, Schneider-Stock R: Aberrant hypermethylation profiles in colorectal cancer [abstract]. In: American Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18 2007; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 1126A

61. Razvi MH, Dar A, Washington MK, El-Rifai W: Oncogenomic transcriptional hotspots in Barrett’s adenocarcinomas. In: American Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18 2007; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 2981

62. Vilgelm A, El-Rifai W, Wei J, Zaika AI: Overexpression of DeltaNp73alpha induces drug resistance in human gastric carcinoma cells through upregulation of the MDR1 gene. In: American Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18 2007; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 454

63. Lee W, Belkhiri A, Lockhart AC, Merchant N, Yeatman TJ, Coffey RJ, Washington MK, El-Rifai W: Overexpression of organic anion transporting polypeptide 1B3 (OATP1B3) may be an early event in colon tumorigenesis, associated with apoptosis resistance in colon cancer. In: American Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18 2007; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 5141

64. Peng D, Sheta E, Moskaluk C, Washington K, Goldknopf I, El-Rifai W: Proteomic profiling reveals novel alterations in Barrett’s-related adenocarcinomas. In: American Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18 2007; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 2241

65. Belkhiri A and El-Rifai W: t-Darpp antagonizes ceramide-induced apoptosis: up-regulation of Bcl2 through active CREB/ATF-1. In: American Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18 2007; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 423

66. Dar AA, Belkhiri A, Piazuleo B, Peng D, Correa P, Koyama T, Castellas A, Washington K, Zaika A, El-Rifai W: The molecular and biological significance of Aurora Kinase A overexpression in upper gastrointestinal adenocarcinomas. In: American Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18, 2007; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr LB-334

67. Wei J, O’Brien D, Vilgelm A, Piazuelo MB, Washington MK, El-Rifai W: Interactions of P73 and p63 proteins play important role in H. pylori infection. In: Program and abstracts of Digestive Disease Week and the 108th Annual Meeting of the AGA Institute; May 19-24, 2007; Washington, DC. Abstract 1019

68. Vilgelm A, El-Rifai W, Wei J, Zaika AI: Isoform of P73 protein, Deltanp73, induces drug resistance in human gastric cancer cells. In: Program and abstracts of Digestive Disease Week and the 108th Annual Meeting of the AGA Institute; May 19-24, 2007; Washington, DC. Abstract T2189

69. Lee W, Lockhart AC, Belkhiri A, Merchant N, Yeatman TJ, Coffey RJ, Washington MK, El-Rifai W: Organic anion transporting polypeptide 1B3 (OATP1B3) overexpression may be associated with apoptosis resistance and predictive of clinical outcomes in colon cancer. In: Program and abstracts of Digestive Disease Week and the 108th Annual Meeting of the AGA Institute; May 19-24, 2007; Washington, DC. Abstract 67

70. Razvi M, Dar A, Washington K, El-Rifai W: Transcriptional hotspots in Barrett’s related adenocarcinomas. In: Program and abstracts of Digestive Disease Week and the 108th Annual Meeting of the AGA Institute; May 19-24, 2007; Washington, DC. Abstract 907


71. Peng D, Sheta E, Powell SM, Washington K, Moskaluk CA, Goldknopf I, El-Rifai W: Novel alterations in Barrett’s-related adenocarcinomas. In: Program and abstracts of Digestive Disease Week and the 108th Annual Meeting of the AGA Institute; May 19-24, 2007; Washington, DC. Abstract S1982

72. Dar A, Zaika AI, Piazuelo M, Belkhiri A, Washington K, El-Rifai W: Overexpression of Aurora kinase A in Barrett’s adenocarcinomas is associated with potent anti-apoptotic properties. In: Program and abstracts of Digestive Disease Week and the 108th Annual Meeting of the AGA Institute; May 19-24, 2007; Washington, DC. Abstract M1942

73. Belkhiri A, El-Rifai W: t-Darpp suppresses ceramide-induced apoptosis: Upregulation of Bcl2 and preservation of the mitochondrial membrane potential. In: Program and abstracts of Digestive Disease Week and the 108th Annual Meeting of the AGA Institute; May 19-24, 2007; Washington, DC. Abstract T2134

74. Wei J, O’Brien D, Vilgelm A, Piazuelo M, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika AI: Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. In: Program and abstracts of American Association for Cancer Research Annual Meeting: Proceedings; Apr 12-16, 2008; San Diego, CA. Philadelphia (PA): AACR; 2008. Abstract nr LB-163

75. Walluscheck D, Neumann V, Fathke C, Agaimy A, Poehlmann A, Guenther T, Wuensch P, Schulz H-U, Vieth M, Stolte B, El-Rifai W, Roessner A, Schneider-Stock R: Oxidative stress-induced DNA-damage in the Barrett’s carcinogenesis. In: Program and abstracts of American Association for Cancer Research Annual Meeting: Proceedings; Apr 12-16, 2008; San Diego, CA. Philadelphia (PA): AACR; 2008. Abstract nr 3138

76. Peng D, Razvi M, Chen H, Roessner A, Schneider-Stock R, El-Rifai W: Frequent dysfunction of the members of the Mu-class glutathione-S-transferases and glutathione peroxidases by DNA hypermethylation in Barrett’s-related adenocarcinomas. In: Program and abstracts of American Association for Cancer Research Annual Meeting: Proceedings; Apr 12-16, 2008; San Diego, CA. Philadelphia (PA): AACR; 2008. Abstract nr 4307

77. Belkhiri A, Dar A, El-Rifai W: T-Darpp Induces Tumor Formation In Vivo and Promotes Cancer Cell Survival Through AKT-Dependent Mechanism. In: Program and abstracts of Digestive Disease Week; May 17-22, 2008; San Diego, CA. Abstract 75

78. Dar A, Belkhiri A, Piazuelo MB, Correa P, Zaika AI, Castells A, El-Rifai W: Aurora Kinase a Abrogates Drug-Induced Apoptosis Through Regulating p53 in AKT-Dependent Mechanism. In: Program and abstracts of Digestive Disease Week; May 17-22, 2008; San Diego, CA. Abstract M1610

79. Peng D, Razvi D, El-Rifai W: Members of the Glutathione Pathways Are Frequent Inactivated By Promoter Hypermethylation in Barrett’s Adenocarcinoma. In: Program and abstracts of Digestive Disease Week; May 17-22, 2008; San Diego, CA. Abstract M2014

80. Dar A, Belkhiri A, Piazuelo MB, Zaika AI, Castells A, Pera M, Washington K, El-Rifai W: Effect of aurora kinase A on drug-induced apoptosis and regulation of p53 in an Akt-dependent mechanism. In: Program and abstracts of Gastrointestinal Cancers Symposium 2009; January 15-17, 2009; San Francisco, CA. Abstract nr 33

81. Peng D, Washington K, Chen H, Schneider-Stock R, El-Rifai W: Silencing of the glutathione family members by promoter DNA hypermethylation in esophageal adenocarcinoma. In: Program and


abstracts of Gastrointestinal Cancers Symposium 2009; January 15-17, 2009; San Francisco, CA. Abstract nr 24

82. Belkhiri A, Arteaga CL, El-Rifai W: Expression of t-DARPP confers resistance to trastuzumab in breast cancer cells. In: Program and abstracts of American Association for Cancer Research 100th Annual Meeting: Proceedings; April 18-22, 2009; Denver, CO. Philadelphia (PA): AACR; 2009 Abstract nr 4371

83. Belkhiri A, Dar A, Soutto M, Piazuelo MB, Correa P, Washington K, El-Rifai W: The Aurora Kinase a Regulates GSK-3β/β-Catenin/Tcf Complex Signaling in Gastric Cancer Cells. In: Program and abstracts of Digestive Disease Week; May 30 - June 3, 2009; Chicago, IL. Abstract 1090

84. Soutto M, Peng D, Shahid M, Roessner A, Schneider-Stock R, El-Rifai W: Silencing of CHFR By Loss of DNA Copy Numbers and Promoter Hypermethylation in Esophageal Adenocarcinoma. In: Program and abstracts of Digestive Disease Week; May 30 - June 3, 2009; Chicago, IL. Abstract S1959

85. Peng D, Soutto M, Hu T-L, Washington K, El-Rifai W: Silencing of Glutathione Peroxidase 7 in Esophageal Adenocarcinomas. In: Program and abstracts of Digestive Disease Week; May 30 - June 3, 2009; Chicago, IL. Abstract S1960

86. Belkhiri A, Dar A, Zaika AI, Ecsedy J, El-Rifai W: Aurora Kinase a Regulates p73-Dependent Apoptosis in Gastrointestinal Cancers. In: Program and abstracts of Digestive Disease Week; May 30 - June 3, 2009; Chicago, IL. Abstract T2012

87. Vilgelm A, Wei J, Washington K, El-Rifai W, Zaika AI: Interactions Within the p53 Protein Family Play Critical Role in Cancer Chemotherapeutic Treatment: New Insights Into Chemotherapeutic Drug Response in Gastrointestinal Tumors. In: Program and abstracts of Digestive Disease Week; May 30 - June 3, 2009; Chicago, IL. Abstract W1921

88. Sehdev V, Zaika A, Washngton K, Ecsedy J, El-Rifai W: In: Program and abstracts of Gastroinestinal Cancer Sympsium; January 21-24, 2010; Orlando, FL.

89. Mohammed Soutto, Barbara G. Schneider, M. Blanca Piazuelo, Alexander Zaika, Mary Kay Washington, Sheila E. Crowe, Pelayo Correa, Richard M. Peek, Wael M. El-Rifai: Molecular Signature of NF-kB Signaling in the TFF1-Knockout Mouse Model of Gastric Neoplasia. In: Program and abstracts of Digestive Disease Week; May 1-5, 2010; New Orleans, LA. Abstract 847i

90. DunFa Peng, Tian-Ling Hu, Wael M. El-Rifai: Dynamic Epigenetic Changes of MT3 Promoter Regulate Its Expression in Esophageal Adenocarcinomas. In: Program and abstracts of Digestive Disease Week; May 1-5, 2010; New Orleans, LA. Abstract T1711

91. Anna Vilgelm, Seung-Mo Hong, Jinxiong Wei, Wael M. El-Rifai, et al.: Role of p73 and Mechanisms of Its Regulation in Gastrointestinal Tumors. In: Program and abstracts of Digestive Disease Week; May 1-5, 2010; New Orleans, LA. Abstract W1754

92. DunFa Peng, Tian-Ling Hu, Regine Schneider-Stock, Rupesh Chaturvedi, Keith T. Wilson, Wael M. El-Rifai: Glutathione Peroxidase-7: An Epigenetically Silenced Gene With Dual Functions in Esophageal Adenocarcinomas. In: Program and abstracts of Digestive Disease Week; May 1-5, 2010; New Orleans, LA. Abstract 183

93. Jinxiong Wei, Toni Nagy, Anna Vilgelm, Judith Romero-Gallo, Mary Kay Washington, Pelayo Correa, Wael M. El-Rifai, Richard M. Peek, Alexander Zaika. Helicobacter pylori Actively


Dysregulates p53 Tumor Suppressor. In: Program and abstracts of Digestive Disease Week; May 1-5, 2010; New Orleans, LA. Abstract 683

94. Vikas Sehdev, Jeffrey Ecsedy, M. Kay Washington, Wael El-Rifai. Aurora kinase A: A promising target in gastrointestinal adenocarcinomas. EORTC-NCI-ASCO Annual Meeting on Molecular Markers in Cancer. October 18-20, 2010, Hollywood, Florida

95. Bhavatarini Vangamudi, Kaushik Mukherjee, Abbes Belkhiri, Alexander Zaika, Wael M. El-Rifai: T-Darpp Regulates the GSK3β and β-Catenin/Tcf Signaling. In: Program and abstracts of Digestive Disease Week; May 1-5, 2010; New Orleans, LA. Abstract W1752

96. Shoumin Zhu, Abbes Belkhiri, Alexander Zaika, Wael El-Rifai: Darpp-32 Mediates Activation of PI3K Signaling and Resistance to Gefitinib in Gastric Cancer. In: Program and abstracts of Digestive Disease Week; May 5-10, 2011; Chicago, IL. Abstract Mo1937

97. Tilman T. Rau, Anja Rogler, Peter Konturek, Arno W. Dimmler, Gerhard Faller, Wael El-Rifai, Arndt Hartmann, Reinhard E. Voll, Regine Schneider-Stock: Promotor Methylation in Gastric Cancer - a Functional Trigger of Intestinal Differentiation Under Special Consideration of Cdx1 Expression and NfκB Signalling. In: Program and abstracts of Digestive Disease Week; May 5-10, 2011; Chicago, IL. Abstract Mo1899

98. Abbes Belkhiri, Suhayl M. Mehio, Shoum Zhu, Wael El-Rifai: Darpp-32 Promotes TRAIL Resistance Through Regulation of BCL-XL in Gastric Cancer Cells. In: Program and abstracts of Digestive Disease Week; May 5-10, 2011; Chicago, IL. Abstract Mo1952

99. DunFa Peng, Abbes Belkhiri, Wael El-Rifai: Regulation of oxidative DNA damage by Glutathione Peroxidase 7 in Barrett’s tumorigenesis. In: Program and abstracts of Digestive Disease Week; May 5-10, 2011; Chicago, IL. Abstract 571

100. Vikas Sehdev, Mohammed Soutto, Abbes Belkhiri, Jeffrey Ecsedy, Wael El-Rifai: MLN-8237 treatment alone and in combination with Cisplatin suppresses in vitro and in vivo progression of gastrointestinal cancer cells. In: Program and abstracts of Digestive Disease Week; May 5-10, 2011; Chicago, IL. Abstract 666

101. Mohammed Soutto, Abbes Belkhiri, M. Blanca Piazuelo, Kay Washington, Pelayo Correa, Richard M. Peek, Wael El-Rifai: TFF1 modulates NFκB signaling and the development of gastric neoplasms. In: Program and abstracts of Digestive Disease Week; May 5-10, 2011; Chicago, IL. Abstract 951

Wael El-Rifai, MD., Ph.D. Nashville, October 15, 2011

wael el-rifai, m.d., ph.d. curriculum vitae 1(24) · 1986 – 87 medical intern, ain shams...

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