Company presentation for investors

International Medical tourism for medical treatment with

Botulinum Toxin type A (Botox®)

Try to imagine• You need to urge to toilet up to 30 times a day• You can‘t get your sleep as you need to get up to toilet 5 times

during the night

Try to imagine• You need to urge to toilet up to 30 times a day• You can‘t get your sleep as you need to get up to toilet 5 times

during the night• When you go in the city, you know all toilets near by as you are

afraid you can‘t make it to a toilet in time• You avoid to travel due to this fact• You go to toilet but you cannot empty your bladder fully so that you

have the feeling you need to go again after a short period of time

Try to imagine• You need to urge to toilet up to 30 times a day• You can‘t get your sleep as you need to get up to toilet 5 times

during the night• When you go in the city, you know all toilets near by as you are

afraid you can‘t make it to a toilet in time• You avoid to travel due to this fact• You go to toilet but you cannot empty your bladder fully so that you

have the feeling you need to go again after a short period of time• You stand in the toilet by you have problems to pee or the stream is

very week• Your life is controlled by only one topic, your urinary incontinence• You lose your self esteem as well as your quality of living – you do

take part in life

Wouldn‘t you try every human possible to get you life quality back?

A life with out the constant urge to toilet and the fear to loose urine uncontrolled.

Relief of a disease that no one speaks about.

Caused by

• An overactive bladder (oab) in women and men

• An enlarged prostate (benign prostatic hyperplasia - bph) in men

In the European Union

• Approx. 17% of citizens suffer by an overactive bladder, from that 2/3 are incontinent = this makes in total approx. 56.000.000 people

In the European Union

• Approx. 17% of citizens suffer by an overactive bladder, from that 2/3 are incontinent = this makes in total approx. 56.000.000 people

• Suffer approx. 13.000.000 men from symptoms of a enlarged prostate (50% of all men from 50 years – this share is growing with the age)

Because of the ageing population=> the tendency is rapidly growing

Treatment Options

• Medication often have many side effects

Treatment Options

• Medication often have many side effects• Studies showing that within one year, a half of patients

stop with their medication therapies due to lack of effect (inefficacious)

Treatment Options

• Medication often have many side effects• Studies showing that within one year, a half of patients

stop with their medication therapies due to lack of effect (inefficacious)

• Prostate surgeries are not easy, painful and have risks that most men deters. Risks are impotence and incontinence

The advanced treatment employing Botulinum Toxin (Botox®)

• In 30 minutes in an ambulant set up is Botox® injected into prostate or bladder ultrasound guided

• The patient can after the treatment leave the clinic

The advanced treatment employing Botulinum Toxin (Botox®)

• In 30 minutes in an ambulant set up is Botox® injected into prostate or bladder ultrasound guided

• The patient can after the treatment leave the clinic• After 10-14 days the patient feel a significant improvement of

symptoms

The advanced treatment employing Botulinum Toxin (Botox®)

• In 30 minutes in an ambulant set up is Botox® injected into prostate or bladder ultrasound guided

• The patient can after the treatment leave the clinic• After 10-14 days the patient feel a significant improvement of

symptoms• The quality of living is back for 9-12 month before the symptoms

come back• The treatment can be repeated and lead to freedom of symptoms at

all when repeated• Although mild and effective, this method is not actively promoted by

clinics• Only a few clinics in Germany, Swiss and UK are specialized and

perform this treatment (in many other countries it is unavailable)

Medical Tourismus in Germany• 2012 have been more than 200.000 patients for treatment to

Germany and paid in total more than 1.000.000.000 EUR • 7,5% increase over previous year (the year before 9,5%)

Medical Tourismus in Germany• 2012 have been more than 200.000 patients for treatment to

Germany and paid in total more than 1.000.000.000 EUR • 7,5% increase over previous year (the year before 9,5%)• About 100.000 patients are from Russia (CIS), other from neighbor

countries of Germany; it rapidly gaining popularity by patients from the Gulf States who accompanied by their entire family

Medical Tourismus in Germany• 2012 have been more than 200.000 patients for treatment to

Germany and paid in total more than 1.000.000.000 EUR • 7,5% increase over previous year (the year before 9,5%)• About 100.000 patients are from Russia (CIS), other from neighbor

countries of Germany; it rapidly gaining popularity by patients from the Gulf States who accompanied by their entire family

• Reasons are:– Weak medical infrastructures of other countries– A high technology and medical quality in Germany– No or difficult access to special treatments

Boto Medical

• Pave the path to renowned specialists

Boto Medical

• Pave the path to renowned specialists• Works jointly with leading urologists in Germany in this

area• Creates awareness of the treatment method with

Botox® in Europe and furthermore in targeted countries as Russia and Gulf States

Boto Medical

• Pave the path to renowned specialists• Works jointly with leading urologists in Germany in this area• Creates awareness of the treatment method with Botox® in

Europe and furthermore in targeted countries as Russia and Gulf States

• Offers any imaginable services around the treatment and stay of domestic and foreign patients in their native language

• From first contact request, organization of VISA or entire conveyance as well accommodation or fringe events for accompanying persons and many many more…

The treatment in detail

• As following Prof. Doz. Dr. Seif (3,5 min) explains the enlarged prostate treatment

• Further details and videos on our web pages at www.boto-medical.com

Use of capital

• We‘ll use your invested capital

Use of capital

• We‘ll use your invested capital• For expansion, penetration and extension of portfolio

into the targeted countries• Claiming a trade mark for better marketing

Use of capital

• We‘ll use your invested capital• For expansion, penetration and extension of portfolio

into the targeted countries• Claiming a trade mark for better marketing• Strategically expansion of cooperation and affiliation

network locally and in foreign countries• Online and print advertising• Expansion and development of website to a

information platform with further languages and services such as e.g. telemedicine

Imprint• BOTO MEDICAL GMBH

Mittelweg 14420148 Hamburg

• ContactTel.: 04154 - 595 3074E-Mail: info@boto-medical.com WWW: www.boto-medical.com

• Business registration HRB 119959 HamburgVAT No.: 42/708/01124CEO: Michael Stoye

All rights reserved - Boto Medical GmbH - 2014

• Sources:– National Institute of Diabetes & Digestive & Kidney Diseases of the National Institutes of Health. Verfügbar unter:

http://www.niddk.nih.gov. – Prävalenz des BPH-Syndroms in Deutschland: Studie des AK-BPH der Deutschen Gesellschaft für Urologie– Eurostat http://epp.eurostat.ec.europa.eu– Milsom I et al. How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence

study. BJU International, 2001; 87; 760-766Irwin DE. et al. Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study. European Urology, 2006;50: 1306–1315

– Pelletier EM et al. Pharmacotherapy adherence and costs versus nonpharmacologic management in overactive bladder. Am J Manag Care 2009; 15: S108–14D’Souza A et al. Persistence, adherence and switch rates among extended-release and immediate-release overactive bladder medications in a regional managed care plan. JMCP, 2008; 14: 291-301