Warm UpWrite down as much as you know

about the endocrine system.◦What is it made up of?◦Where is it located?◦What is its purpose?

Objective:◦SWBAT

Explain why steroid hormones act directly on target organs while amino acid hormones act through secondary messengers

Agenda:◦Notes: Intro to Endocrine◦Hormone Chart Relay◦Closing

Homework:◦Essay due Monday 3/17

Notes: Intro to EndocrineOverviewRelatively small and unconnected glands

◦ Produce:Slow acting chemical messengers called

hormones◦ Which act on:

Specific locations called target organs

Two Types of HormonesAmino-acid based—polar

◦ All but those produced by adrenal cortex and gonadsSteroid-based—nonpolar

◦ Those produced by adrenal cortex and gonads

Hormone Release◦ Hormonal—hormones from one gland stimulate the release of

hormones from another gland◦ Humoral—too low or too high of an amount of nutrients in the

blood signal release of hormones◦ Neural—stimulation of the nervous system stimulates release

of hormones

Mechanisms of Hormone Action Direct Gene Activation (nonpolar steroid hormones)

◦ Diffuse through target’s plasma membrane into nucleus where they begin DNA transcription and translation of new proteins

Second-Messenger System (polar amino acid hormones)◦ Cannot diffuse through target’s plasma membrane◦ Instead, must bind to receptor on surface of target, activating

a secondary messenger

Hormone Regulation Negative feedback—hormone levels rise until certain

point; then high levels “tell” body to stop producing more hormone

Hormone Chart Relay

You will be assigned to 1 of 7 groups of 4 students◦ You will be responsible for researching a total of 3

assigned hormones◦ But you will only be given 1 hormone at a time◦ You cannot move to the next hormone until the first

hormone information is correctAssign the following roles

◦ Researcher— determine the function (www.nlm.nih.gov and www.mayoclinic.org)

◦ Scribe—write down the function◦ Classifier—determine the type of hormone and what its

regulated by◦ Typer—have slip checked by Ms. McGowan and type

into class chartFinally, we will review our chart as a class

Warm UpWhy do steroid hormones act

directly on target organs while amino acid hormones act through secondary messengers?

Objective:◦SWBAT

Explain the stimulation, action, and regulation of one hormone

Agenda:◦Review: Intro to Endocrine◦Hormone Chart◦Hormone Scavenger Hunt◦Closing

Homework:◦Essay due Monday 3/17

Label the glands below using the following terms:

Hypothalamus, pituitary, and pineal

Thyroid and parathyroid

ThymusAdrenalPancreasOvariesTestes

http://wps.aw.com/bc_campbell_concepts_6_oa/95/24514/6275825.cw/index.html

Use the video below to label your glands:

http://www.pennmedicine.org/encyclopedia/em_DisplayAnimation.aspx?gcid=000048&ptid=17

Hormone ChartFollow along as we fill out the

hormone chart we made yesterday

Hormone Scavenger HuntIndividually, you will complete a

scavenger hunt around the roomStart at any station write down

the station #, question, and your answer

Then, search around the room for your answer this will lead you to your next question

You will be graded on the order you visit each station (There is only one way!)

Warm UpChoose one hormone you learned

about yesterday and explain its function.

Consider how it is stimulated, how it acts, and how its regulated.

Objective:◦SWBAT

Explain how the imbalance of one hormone causes at least one disorder

Agenda:◦Hormone Scavenger Hunt◦Guided Notes: Endocrine Development

and Issues◦Closing

Homework:◦Essay due Monday 3/17

Hormone Scavenger HuntIndividually, you will complete a

scavenger hunt around the roomStart at any station write down

the station #, question, and your answer

Then, search around the room for your answer this will lead you to your next question

You will be graded on the order you visit each station (There is only one way!)

Warm UpChoose one hormone we have

previously learned about.What would happen if there was

too much of this hormone? Too little?

Objective:◦SWBAT

Explain how the imbalance of one hormone causes at least one disorder

Agenda:◦Guided Notes: Endocrine Development

and Issues◦Application Questions◦Closing

Homework:◦Finish Application Questions

Notes: Endocrine Development

Endocrine glands begin deteriorating in old age◦Example: Menopause—deterioration

of gonads causes loss of ability to bear children, hot flashes, etc.

Also, during pregnancy, the placenta produces human chorionic gonadotropin (hCG) that stimulates continued production of estrogen and progesterone

Notes: Endocrine IssuesSterility—under secretion of FSH

and/or LHGigantism--over secretion of GH in

children affects long bonesAcromegaly—over secretion of GH in

adults affects skull, hands, and feetPituitary dwarfism--under secretion

of GHDiabetes insipidus—under secretion

of ADH leads to excessive urination (polyURIA) and thirst (polydipsia)

Notes: Endocrine IssuesGoiter—excessive release of T3/T4 due to a

lack of iodine causes a noticeable enlargement of the thyroid

Creatinism—under secretion of T3/T4 due to under secretion of TSH in children leads to dwarfism and mental retardation

Myxedema—under secretion of T3/T4 due to under secretion of TSH in adults leads to physical and mental sluggishness

Graves’ disease—over secretion of T3/T4 due to a tumor leads to increased metabolism and bulging eyes

Notes: Endocrine IssuesTetany—low blood calcium leads to

overactive neurons and therefore muscle spasms

Hyperparathyroidism—high blood calcium leads to bone fragility and spontaneous fractures

Addison’s disease—under secretion of adrenal cortex hormones leads to a bronze tone and muscle weakness

Hyperaldosteronism—over secretion of ALDOSTERONE leads to hypertension and edema

Notes: Endocrine IssuesCushing’s syndrome—over secretion

of adrenal cortex hormones leads to swollen face and hump of fat on upper back

Diabetes mellitus—under secretion of insulin leads to excessive urination (polyURIA) and thirst (polydipsia)

Masculinization—over secretion of sex hormones leads to excessive male features in both sexes

Application QuestionsWork together to answer your

application questionsWhen you finish, we will review

them as a class

ClosingPick one of the diseases you

learned about today and explain how it is caused by imbalance of 1 hormone.

Warm UpPick one of the diseases you learned

about yesterday and explain how it is caused by imbalance of 1 hormone.

Take out your Application Questions for completion points

Objective:◦SWBAT

Explain the difference between Type 1 and Type 2 Diabetes mellitus

Agenda:◦Review Application Questions◦Bluff◦Closing

Homework:◦Endocrine Systems Quiz Tomorrow

Application QuestionsFollow along as we review your

endocrine application questions Make sure you have the correct

answers down!

BluffRaise your hand if you have ever

played BluffWho would like to explain the

rules?

Closing Compare and contrast type 1 and

type 2 diabetes.

Warm UpAny last questions before your

endocrine system quiz?

Objective:◦ SWBAT

Score >80% on their endocrine system quiz Explain why blood is red, but appears blue

Agenda:◦ Endocrine System Quiz◦ Close Reading: Why are veins blue?◦ Notes: Composition of Blood◦ Closing

Homework:◦ Write two questions you have about blood or the

cardiovascular system on a half sheet of paper◦ Find out your blood type! (ask your parents)

Endocrine System QuizPut everything away except for a

writing utensilIf you have a question during

your quiz, raise your hand and I will come answer it

Hold on to your quiz when you finish; I will collect them all at the same time

Good luck!

Close Reading: Why do veins appear blue?Working individually, read and

answer the questions related to your reading, “Why do veins appear blue?”