wbc & platelets anomalies
TRANSCRIPT
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WBC & PLATELETS ANOMALIESPRINCESS ALEN AGUILAR
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WBC anomalies
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Toxic granulation
• Dark blue-black cytoplasmic granules in neutrophil• Thought as primary granules• Show inc.alkaline phosphatase activity• Found in: acute infections
drug poisoning
burns
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Dohle Bodies
• Single or multiple light blue or gray areas in cytoplasm of neutrophils• RER & represent failure of cytoplasm to mature• Found in: infections
poisoning
burns
following chemotherapy
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Hypersegmented Neutrophils
• Neutrophils with six or more lobed nucleus• Represents an abnormality in maturation of neutrophil• Acquired(in megaloblastic erythropoiesis) or inherited(Undritz
anomaly)• Found in: pernicious anemia
folic acid deficiency
chronic infections
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Barr Body
• Sex chromatin• Represents the second X chromosome in females (2-
3% of neutrophils in females)• Small,well-defined,round projection of nuclear
chromatin• These cells are not found in normal males.
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Degenerated Neutrophil w/ pyknotic nucleus
• Result from condensing of nuclear chromatin into a solid structure mass with no pattern
• Not counted in differential cell count
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Vacuolated neutrophil
• Degeneration of cytoplasm begins to acquire holes or as result of active phagocytosis
• May reflect increased lysosomal activity• Found in: septicemia
severe infection
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Giant Neutrophils
• Can be seen occasionally in normal peripheral blood smear• Larger than normal neutrophils and genrally hyperlobulated• Found in frequency of 1 in every 20,000 neutrophils but
increase in disease states
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Pelger-Huet Anomaly
• Indicates failure of neutrophil to segment properly
• Bi-lobed nucleus; chromatin is coarsely clumped
• May be inherited or acquired (as in leukemias)
• Heterozygous for this char.shows numerous bi-lobed (dumbell shape); homozygous-round neutrophil
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Chediak-Higashi Syndrome(Autosomal recessive
disorder)• Rare,fatal disprder found in
children• Inherited as an autosomal
recessive char.• Contain very large,reddish-
purple or greenish-gray staining granules in the cytoplasm of granulocytes
• In monocytes & lymphocytes, stain bluish-purple
• These granules represent abnormal lysosomes
• Found in: anemia
neutropenia
thrombocytopenia
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Alder-Reilly anomaly
• Heavy,coarse blue-black granules of BEN & sometimes lymphocytes & monocytes
• Inherited condition• Associated with Hurler’s
syndrome & Hunter’s syndrome
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May-Hegglin Anomaly
• Inherited anomaly affecting neutrophils and platelets• Larger than usual Dohle-like bodies• Giant bizarre platelets is present & function may be
abnormal
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Auer rods
• Rod-like bodies representing aggregated primary granules that stain reddish purple
• Found in : cytoplasm of myeloblast, monoblast and promyelocytes in acute monocytic or acute myelogenous leukemia and eythroleukemia
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Smudge or Basket cell
• Disintegrating nucleus of ruptured WBC
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PLATELETS SATELLITOSIS
• Platelets encircling the peripheral borders of neutrophils
• This phenomenon is thought to be due to a serum factor which reacts in the presence of EDTA.