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University Business Academy in Novi Sad

Faculty of Pharmacy, Novi Sad

Integrated academic studies - Pharmacy

Title of study programme PharmacyEducational-scientific / educational-art field

Medical sciences

Scientific, professional or artistic field Pharmaceutical sciencesType and Level of Studies integrated academic studiesModules /Study load (ECTS) 300Study lenght 5 years, 10 semestersTitle Master of PharmacyNumber of students 60Language of study programme Serbian, EnglishWeb www.faculty-pharmacy.com

http://www.faculty-pharmacy.com/

Structure of study programmeStudy program of integrated studies Pharmacy to acquire the academic title of Master of Pharmacy, lasts 5 years and is performed in 10 semesters with a total of 4.035 hours of instruction. Classes are held in the form of lectures, practical exercises, seminars, field trips, themed workshops, undergraduate practice and students research work in function of thesis production.Total engaging students through all forms of education provided is expressed by the number of 300 ECTS. The implementation of ECTS was performed according to nonmodularised system (subjects can have different number of points so that the total number of credits in one academic year is 60). The number of points for each subject is determined by comparison of the tasks that the student needs to do in order to achieve the objective and learning outcome. Students receive points specified for the subject after passing the final exam.During I, II and III semester students mostly acquire knowledge in basic sciences that are relevant to the study of pharmacy and basic medical sciences. During IV, V, VI, VII, VIII and IX semester classes are oriented to pharmaceutical professional subjects and objects of medical sciences which are closely related to the pharmacy. During the X semester students can start preparing graduate work under the terms and conditions as set forth in the Statute and in relevant Regulations. During X semester, students perform undergraduate practice in public pharmacies and in hospital sector.Elective courses are designed in IV, V, VI, VIII and IX semester. The curriculum of elective courses are also designed to allow students to expand their knowledge on some topics that are less processed within the required subjects, improve their informatical skils and gain a good basis for doing research work and to appropriately get familiar with the basic principles of pharmaceutical and clinical medicine.Classes in all subjects is conducted in one semester in accordance with the teaching plan.The most important methods of teaching are:

1. Interactive lectures2. Practical work of students in laboratories3. Seminars4. Fieldwork

Interactive lectures features a discussion of teachers with students on the topic that is the subject of teaching and allows students a better understanding of the material compared to traditional theoretical teaching ex cathedra. This kind of teaching is characterized by the use of multimedia presentations as contemporary means of displaying the content of teaching.Students' practical work in the laboratoriy is performed as a demonstration of certain procedures or skills, with the active participation of students in independent experimental work with a defined goal (the result of analysis, synthesis products, etc..).Seminars allow students to rehearse the independent use of literature, electronic databases and presentation of selected topics that were processed with minimal help of teachers and subjects assistants.Field work enables students to carry out activities that can not be adequately implemented in the laboratory (e.g. collection and processing of plant material) or to learn about certain aspects of the profession in real terms (i.e. visits to production facilities).

Aim of study programmeStudy program of integrated academic studies in Pharmacy is based on the Law of High Education of the Republic of Serbia, the principles of the European High Education contained in the Bologna Declaration, opinions and recommendations of international academic and professional associations in the field of pharmacy and, above all, the needs of society for highly educated staff that can follow the rapid development of science and practice in the field of pharmacy. The program is in line with the recommendations and standards of the National Council for Higher Education, Ministry of Education,

Science and Technological Development of the Republic of Serbia.This study promotes the principles that are generally accepted by the academic community in developed countries:

- Streamlining and modularisation of curricula,- Implementation of ECTS,- The introduction of new types of teaching and new methods of teaching,- Insistence on continual work of students,- Introduction of quality control of the curriculum and methods of teaching,- Participation of students as partners in the educational process.

The study program has a clearly defined purpose:- Efficient study,- A higher level of technical and scientific competence of graduates of pharmacy as a general social

and national interest,- Alignment of curriculum with programs of European high education institutions involved in educa-

tion of pharmacists (in terms of quality, scope and methodological approach), which would allow greater mobility of students and teachers,

Introduction of standards in the process of evaluation of knowledge, skills and professional competencies that are comparable to the standards of the European Union, in order to pharmacy students be equal to their colleagues in the European region.

Objectives of study programme

The overall objective of the study program is to Pharmacy graduates have a high level of knowledge about the drug and the patient, and to be well trained to work independently in the future profession and to achieve high standards of academic behavior (especially ethics and morality), in profession and in society in general. One of the most significant and strategically important goals of high education in every developed society, as well as this program is also to get a good basis for further professional and scientific training of graduate students.Accordingly, the general objectives of the study program of integrated academic studies in pharmacy are to enable graduates to perform activities in the following fields:

- Health care (primary, secondary and tertiary health care; institutes),- Industry (pharmaceutical manufacturing, drug distribution, drug marketing),- Education, Science and Research (middle, high graduate and postgraduate education; scientific

research; continual professional education),- Legislation (Agency for Medicines and Medical Devices of Republic of Serbia and other relevant

institutions).The specific objectives of this study program are to provide students with skills and knowledge related to:

- Issuing of drugs and their use,- Monitoring the safety, efficiency and cost-effectiveness of treatment,- Recognizing interactions, side and toxic effects of drugs,- Preparation of magistral and galenic preparations,- Operational use of analytical methods and techniques,- Operation of appliances and equipment,- Safe handling of chemical and pharmaceutical supplies,- Identification of the main symptoms and signs,- Verbal and written communication with patients, physicians, other health professionals and the

public,- Generating and critical evaluation of information and data,- Use of professional literature and information systems,- Identify and solve problems and make decisions.

In line with these objectives appropriate standards for teaching loads, teaching methods and the selection of teachers and staff who participate in its implementation have been established.

Competencies After the completion of integrated studies in Pharmacy graduate student receives the academic title Mater of Pharmacy and is qualified to perform pharmaceutical health services after the completion of the internship and passing the examination, according to the Regulations on internship and professional examination of health care professionals (Official Gazette of the Republic of Serbia 50/06).In the field of pharmaceutical health services and its competences include:- The implementation of preventive measures for the conservation and protection of public health, as

well as health promotion,- Improvement of pharmacotherapeutic measures and procedures in the rational use of medicines

and certain medical devices,- Rationalisation of costs for the implementation of established therapeutic treatment protocols,- Monitoring of adverse reactions to drugs and medical devices, as well as avoidment or minimiza-

tion of these effects,- Avoiding of therapeutic duplication as result of interaction of the drugs,- Preparation of galenic or magistral drugs in accordance with the law,- Other activities of pharmaceutical health care services in accordance with the law.Degree also provides oportunity apply for the specialist academic and doctoral studies in the fields of medical science (pharmaceutical and medical sciences) and fields of Mathematics and Natural Sciences

(biological, physical and chemical sciences), provided that the average score in the study is at least 8 (eight).Learning OutcomesLearning outcome is a set of knowledge and skills that students should possess after graduation.Knowledge:- Knowledge and critical understanding of the basic facts, principles and theories related to the phar-

maceutical sector,- Ability to applicate gained knowledge and understanding in a practical work in order to meet the

needs of patients and persons professionally engaged in health activities,- Identifying and analyzing problems and planning strategies to resolve them,- A critical evaluation, interpretation and integration of pharmaceutical information and data,- Creation of proffesional and scientific documentation specific to the pharmaceutical sector,- Clear and fair presentation of proffesional and scientific pharmaceutical content orally or in writ -

ing, for the professional and for the wider audience,- Conversion of therapeutic doses and dose regimens,- Interpretation of clinical data about patients,- The ability to contribute to the development of the health system with practice, information and in-

novation,- Interpretation of prescriptions and other orders for medicines and medical devices.Skills:- Safe handling of chemicals and pharmaceutical materials, considering their physical and chemical

properties including specific risks in handling,- Assessment of risks related to the implementation of pharmaceutical procedures and practices,- Independent conducting of pharmaceutical laboratory procedures,- Planning, design and execution of original research, starting with the initial stages of problem iden-

tification and the evaluation and acceptance of the results and findings, along with the ability to select the proper techniques and procedures,

- Handling standard pharmaceutical instruments,- Critical assessment and interpretation of the data obtained from clinical observations and labora-

tory measurements, considering their importance and an appropriate theoretical basics,- The preparation, production and distribution of drugs, including sterile products,- Performing analyzes of drugs,- Ability to counsel patients and other persons regarding the safe and effective use of medications,- An ethical approach in all professional activities,Teamwork within the quality assurance system.

Curriculum Integrated academic studies in Pharmacy to acquire the academic title of Master of Pharmacy last 5 years and are performed in 10 semesters. According to the curriculum of the study program of integrated studies Pharmacy envisaged number of subjects is 50 compulsory and 12 optional, as well as professional (graduate) practice and graduate work. The total number of hours in the curriculum of the study program is 4.035, of which 3.585 hours of active teaching, 2.010 of theoretical and 1.575 hours of practical classes. Total of 750 hours is provided for students research work (225 hours), thesis (75 hours) and professional (undergraduate) practice (450 hours). Total number of ECTS credits for this study program is 300 ECTS (60 ECTS per academic year), with the number of ECTS for students research work (10 ECTS), thesis (5 ECTS) and professional (undergraduate) practice (15 ECTS).The structure of the curriculum provided are general subjects, subjects in the field of basic sciences, subjects in the field of medical sciences, pharmaceutic professional courses and courses in the field of pharmaceutical management and health legislation.

The curriculum provides 12 electives from 12 electoral blocks with a total of 24 courses. The first election bloc is in the fourth semester. In the fifth, sixth, seventh and eighth semester are provided two optional blocks, and three elective blocks in the ninth semester. Offered elective courses by content and complexity follow the required courses.For elective courses, including graduate work, is provided a total of 47 ECTS (15.7%) with a load of 450 classes of active instruction (225 hours of lectures and 225 hours of practical training), 225 hours of students research work and 75 hours of graduate work . Proportion of elective courses is in accordance with the prevailing practice in a number of European high education institutions which educate pharmacists, as documented in the Standard 6 written examples for the international harmonization of study programs.

AdmissionIn study programs organized by the University or high education institution within it, candidates take part under the terms and conditions stipulated by the Law, the Statute and the Rules of studies at the university and conditions of the competition.Conditions of enrollment of foreign citizens are the same as for domestic, with submited proof of knowledge of the instruction language (Serbian language).The University Senate determines the number of students to be enrolled in a study program organized at the University and in high education institutions within it.The Senate decides on competition for admission to the program. Competition shall contain the number of students in each study program organized at the University and at high education institutions in its membership, enrollment requirements, criteria for determining the order of the candidates, the process of implementation of competition, manner and time limits for filing an appeal against the ranking, and the amount of tuition.The number of students enrolled in the Faculty complies with personnel, physical, technical and technological capabilities.Faculty for admission to the program in the first degree is planning an entrance exam, in accordance with the Statute of the higher education institution. The list of candidates shall be determined on the basis of the general success achieved in secondary education (40%) and the results of the entrance exam (60%).Applications for enrollment of students includes the number of students in each degree program, enrollment requirements, criteria for determining the order of candidates, the process of implementation, method and time limits for filing an appeal to the established order, as well as the tuition fee.Faculty announces a competition for study programs that received accreditation. Faculty plans to enroll up to 60 students for integrated academic studies in Pharmacy.The first year of integrated academic studies Pharmacy may be entered by those with a high school of four years diploma, who have a minimum score required on the list of the entrance examination (minimum 24 points). When applying, the candidate selectes direction. For the implementation of the competition, the Dean shall determen a comision. Call for registration is public and it will be published in the media.Candidates who apply for admission to the program take an entrance exam in Chemistry.Candidates are ranked on a base of the success achieved in high school (maximum 40 points), and based on the points earned by the test of knowledge (maximum 60 points). Candidate by both criteria may obtain a maximum of 100 points. If the candidate who qualify for admission does not enroll within the stipulated time, the Faculty will instead enter another candidate in the order of the rankings.The person who completes the study acquires the appropriate professional, academic title in accordance with the law, a student shall feature in the cases provided for by law, and in accordance with the Statute of the Faculty. Their professional title qualification is also presented in the Diploma Supplement (Annex 4.2).Professional title that achieves a graduate of integrated academic studies Pharmacy is a Pharmacist (Mag. Pharm.).Faculty systematically monitors the success of students during their studies and undertake measures of support in case of unsatisfactory success of students, from consultation and other forms of direct assistance

to the student, to corrective measures in the teaching process.Performance of students in mastering certain subjects is evaluated during the teaching process (active participation in class). Tthe total score of the student's case consists of assessments by the student received for pre-exam and for knowledge of the exam.

Student evaluation and progressStudents assessment is carried out through continuous assessment, including monitoring of student activities throughout the year, durring the teaching process of the course. All the parameters of the succeful overcome of certain subject - attendance, learning and connecting facts, application of knowledge, the efficient implementation of practical skills, participation in interactive teaching, knowledge presentation method etc. are being assessed.Examination can enter only a student who has completed all required pre-exam obligations given in the teaching plan of the course.The work of students in mastering certain subjects is continuously monitored during the classes and is expressed in points.By fulfilling exam commitments and taking exams a student can earn a maximum of 100 points, of which 30-70 points in the pre-exam requirements. During the semester there is a constant examination and the final score is determined by the test.Knowledge of the student on the final exam is established by one of the following, or a combination of ways: oral, written and practical exam.Students' scores are expressed as:

- Grade 10 (outstanding) for the achieved 91-100 points- Grade 9 (excellent) for the achieved for 81-90 points- Grade 8 (very good) for the achieved 71-80 points- Grade 7 (good) for the achieved 61-70 points - Grade 6 (sufficient) for the achieved 51-60 points

Grade 5 (failed) for the achieved 0-50 points

List of courses1. Introduction to Pharmacy with the Basics of Scientific Research2. English in Pharmacy3. Biophysics4. Biology with Human Genetics5. Anatomy6. General Chemistry7. Organic Chemistry I8. Histology9. Botany10. Inorganic Chemistry11. Physical Chemistry12. Analytical Chemistry I13. Organic Chemistry II14. Analytical Chemistry II15. Instrumental Pharmaceutical Analysis

16. MolecularCell Biology

17. General Biochemistry18. Immunology19. Physiology I20. Pharmaceutical Inorganic Chemistry21. Physiology II22. Microbiology23. Pharmacognosy I24. Pharmaceutical Organic Chemistry I25. Bromatology26. Statistics in Pharmacy27. Elective 128. Pharmacognosy II29. Pharmaceutical Organic Chemistry II30. Neuroscience31. Pathophysiology32. Pharmacology33. Elective 234. Elective 335. Neuropharmacology36. Dietetics37. Medical Biochemistry38. Pharmaceutical Technology I39. Elective 440. Elective 541. Drug Control and Analytics42. Phytotherapy43. Pharmacokinetics with Pharmacodynamics44. Pharmaceutical Technology II45. Cosmetology46. Elective 647. Elective 748. Pharmacotherapy49. Toxicology with Analytics50. Biopharmacy

51. PharmaceuticalBiotechnology

52. Pharmaceutical Ethics and Law53. Endocrinology54. Elective 855. Elective 956. Industrial Pharmacy

57. Drug Interactions andSide Effects

58. Clinical Pharmacy59. Pharmaceutical Practice60. Elective 1061. Elective 11

62. Elective 1263. Research Work64. Graduation Paper65. Internship

Programme Outline

No. Course Title Module S Status Active training classes

ECTS

L P AC SR

1.Introduction to Pharmacy with the Basics of Scientific Research

1 C 1 0 1

2. English in Pharmacy 1 C 2 2 4

3. Biophysics 1 C 1 1 2

4. Biology with Human Genetics 1 C 2 1 3

5. Anatomy 1 C 2 1 3

6. General Chemistry 1 C 6 5 97. Organic Chemistry I 1 C 7 4 9

8. Histology 2 C 1 1 2

9. Botany 2 C 3 2 7

10. Inorganic Chemistry 2 C 2 1 3

11. Physical Chemistry 2 C 3 1 4

12. Analytical Chemistry I 2 C 2 3 6

13. Organic Chemistry II 2 C 3 3 7

14. Analytical Chemistry II 3 C 2 3 8

15. Instrumental Pharmaceutical Analysis 3 C 3 4 5

16. MolecularCell Biology 3 C 2 1 3

17. General Biochemistry 3 C 2 2 5

18. Immunology 3 C 3 1 4

19. Physiology I 3 C 3 1 4

20. Pharmaceutical Inorganic Chemistry 3 C 2 1 4

21. Physiology II 4 C 3 1 4

22. Microbiology 4 C 3 2 7

23. Pharmacognosy I 4 C 2 2 4

24. Pharmaceutical Organic Chemistry I 4 C 2 3 4

25. Bromatology 4 C 2 2 4

26. Statistics in Pharmacy 4 C 1 1 2

27. Elective 1 4 O 1 1 2

28. Pharmacognosy II 5 C 2 2 4

29. Pharmaceutical Organic Chemistry II 5 C 2 3 7

30. Neuroscience 5 C 2 1 4

31. Pathophysiology 5 C 3 2 5

32. Pharmacology 5 C 3 4 4

33. Elective 2 5 O 1 1 3

34. Elective 3 5 O 1 1 3

35. Neuropharmacology 6 C 2 2 5

36. Dietetics 6 C 1 1 3

37. Medical Biochemistry 6 C 3 3 8

38. Pharmaceutical Technology I 6 C 5 6 8

39. Elective 4 6 O 1 1 3

40. Elective 5 6 O 1 1 3

41. Drug Control and Analytics 7 C 4 3 8

42. Phytotherapy 7 C 1 2 3

43. Pharmacokinetics with Pharmacodynamics 7 C 2 1 3

44. Pharmaceutical Technology II 7 C 3 4 4

45. Cosmetology 7 C 2 2 4

46. Elective 6 7 O 1 1 4

47. Elective 7 7 O 1 1 4

48. Pharmacotherapy 8 C 2 3 6

49. Toxicology with Analytics 8 C 3 1 2

50. Biopharmacy 8 C 2 1 4

51. PharmaceuticalBiotechnology 8 C 3 2 5

52. Pharmaceutical Ethics and Law 8 C 1 1 2

53. Endocrinology 8 C 2 1 3

54. Elective 8 8 O 1 1 4

55. Elective 9 8 O 1 1 4

56. Industrial Pharmacy 9 C 1 1 2

57. Drug Interactions andSide Effects 9 C 1 1 2

58. Clinical Pharmacy 9 C 3 2 9

59. Pharmaceutical Practice 9 C 1 2 560. Elective 10 9 O 2 2 461. Elective 11 9 O 2 2 462. Elective 12 9 O 2 2 463. Research Work 10 C 0 0 15 0 1064. Graduation Paper 10 C 0 0 5 0 565. Internship 10 C 0 0 0 30 15

Course details (list)

No. Course Title1. Introduction to Pharmacy with the Basics of Scientific Research2. English in Pharmacy3. Biophysics4. Biology with Human Genetics5. Anatomy6. General Chemistry7. Organic Chemistry I8. Histology9. Botany10. Inorganic Chemistry11. Physical Chemistry12. Analytical Chemistry I13. Organic Chemistry II14. Analytical Chemistry II15. Instrumental Pharmaceutical Analysis16. Molecular Cell Biology17. General Biochemistry18. Immunology19. Physiology I20. Pharmaceutical Inorganic Chemistry21. Physiology II22. Microbiology23. Pharmacognosy I24. Pharmaceutical Organic Chemistry I25. Bromatology26. Statistics in Pharmacy27. Elective 1 28. Pharmacognosy II29. Pharmaceutical Organic Chemistry II30. Neuroscience31. Pathophysiology32. Pharmacology33. Elective 2

34. Elective 3 35. Neuropharmacology36. Dietetics37. Medical Biochemistry38. Pharmaceutical Technology I39. Elective 4 40. Elective 5 41. Drug Control and Analytics42. Phytotherapy43. Pharmacokinetics with Pharmacodynamics44. Pharmaceutical Technology II45. Cosmetology46. Elective 6 47. Elective 7 48. Pharmacotherapy49. Toxicology with Analytics50. Biopharmacy51. Pharmaceutical Biotechnology52. Pharmaceutical Ethics and Law53. Endocrinology54. Elective 8 55. Elective 9 56. Industrial Pharmacy57. Drug Interactions and Side Effects58. Clinical Pharmacy59. Pharmaceutical Practice60. Elective 10 61. Elective 11 62. Elective 12 63. Research Work64. Graduation Paper65. Internship

BOOK OF SUBJECTS

INTRODUCTION TO PHARMACY WITH BASICS OF SCIENTIFIC RESEARCH

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Introduction to Pharmacy with the Basics of Scientific ResearchTeacher:

Subjects status: compulsorySemester: first year, first semesterECTS: 1Requirement: noSubjects objective:Understanding the importance and role of pharmacy in the health care system, the role of drugs in society, the place and role of the Faculty of Pharmacy in education of pharmacists and the importance and variety of future career; acquiring basic knowledge about the development of pharmacy and the scope of pharmaceutical practice and social responsibility of pharmacists in health care, prevention and disease treatmentSubjects outcome: Student: learns about historical and cultural foundations of the development of pharmaceutical profession and pharmaceutical science; understands professional and social role of the pharmaceutical industry; understands the role and necessity of continuing personal professional development and masters the principles of scientific thinking: understands the needs and perspectives of patients and also knows and applies various communication skills in pharmacy and society (can communicate successfully with patients, colleagues and other public).Subjects content:LecturesProfessional development of pharmacy. The development of pharmacy as a scientific discipline. The most important discoveries relevant to the development of pharmacy. A brief overview of the drug development through time. Professional orientation in the pharmaceutical industry. Principles of pharmaceutical education now and then. The motives for choosing pharmacy as a career. The concept of health and disease. Behavioral aspects of pharmaceutical care. Behavior of a sick man. The concept of mandatory health care. Health, economic and social aspects of the pharmaceutical industry. Communication with colleagues, the media, regulators and users of health care services. Methods and forms of communication. Rules of good communication. Basic concepts of the role of pharmacists in safe and effective use of medications, counseling, informing and educating the patient, health care, prevention and disease treatment.Practical classesAnalysis of case studies, panel discussions, homework on the topic: Communications in pharmacy and society; concept of health and disease; patient’s relationship to disease; health, economic and social aspects of the pharmaceutical industry. Test.Literature: 1. Anderson S. ed., Making Medicines - A brief History of pharmacy and pharmaceuticals, 1 st ed. Pharmaceutical Press,

London, 2005.2. Remington: The Science and Practice of Pharmacy, 21th ed., Lippincott Williams and Wilkins, London, 2006.3. Bissell P. at al., Sociology and Pharmacy Practice, Pharmaceutical Press, London, 2005.4. A. J. Winfield, R. M. E. Richards, Pharmaceutical Practice, Churchill Livingstone, Edinburg, 2004.5. Schmitz R., Geschichte der Pharmazie band II, Govi-Verlag Pharmazeutisher Verlag, GmbH, Eschborn, 2005.Number of active teaching: Other classes:Lectures: 15 Exercises: 0 Other forms of teaching: Students research work: Methods of teaching:interactive lectures, Practical classes, discusions.

Grading (maximum 100 points)Pre-Exame commitments Points Final Exame Points

Lectures 5 Exame 70Practical classes 0Colloquiums 25Seminars 0

ENGLISH IN PHARMACY

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studies Name of subject: English in PharmacyTeacher: Subjects status: compulsorySemester: first year, first semesterECTS: 4

Requirement: noSubjects objective:The objective of this course is to introduce the terminology used in pharmacy, chemistry, biology, and medicine; introduction to the basic concepts of business terminology; establishing and expanding knowledge of basic grammar categories.Subjects outcome: After passing the exam the student will be able to: actively apply basic professional terminology of English in the field of pharmacy, chemistry, biology and medicine, and understand specialized literature in specific areas of the profession, and use the internet.Subjects content:LecturesBasic professional terminology used in: the description, classification, use and prescribing medication; communication with the patient; periodic table of elements, chemical elements, units of measurement, laboratory equipment, laboratory chemicals; health, disease, parts of the plant. Processing basic grammar units (nouns, verbs, sequence of tenses, indirect speech, passive voice, cause and effect).Practical classes Practising verbal communication. Lexical exercises regarding the use of professional terminology. Defining and reformulation. Practising grammar categories necessary for interpreting specialized texts.Literature: 1. Daintith John: The Facts on File Dictionary of Organic Chemistry, Market House Books Ltd, Aylesbury, UK, 2004.2. Kerničan L.: English Language in Pharmacy Practice, Zbirka tekstova i vežbanja, Grafopan, Beograd, 2005.3. Mićić S.: Nazivi bolesti i poremećaja u engleskom jeziku, Beogradska knjiga, Beograd 2004.4. Arneri-Georgijev J.: More Medical Words You Need, Savremena administracij, Beograd, 2002.5. Bujas Z.: Englesko-hrvatsko-engleski rečnik, Nakladni zavod Globus, Zagreb, 2001.6. Horvatović R, Pejić Z.: Engleski jezik za medicinare, stomatologe, veterinare, farmaceute i defektologe, Naučna knjiga,

Beograd, 1990.7. Popović Olja: Engleski jezik za studente hemije, fizičke hemije i srodnih nauka sa terminološkim rečnikom, Građevinska

knjiga, Beograd, 1984.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:interactive lectures, group exercises comunication, audio-exercises, video-projections, analysis of the technical and commercial and cosmetic articles written in English, working with professional English texts on the Internet



BIOPSYSICS

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: BiophysicsTeacher: Subjects status: compulsorySemester: first year, first semesterECTS: 2Requirement: no Subjects objective:Introduction to basic laws of physics and their application, the acquisition of knowledge necessary to work in the laboratory and measurements of physical quantities.Subjects outcome: The student will be able to easily master the contents of other courses, as well as the principles of modern diagnostic and

laboratory instruments (NMR, ultrasound, laser).Subjects content:LecturesChemical thermodynamics (laws of thermodynamics, enthalpy, thermochemistry, entropy, chemical potential). Liquefaction: vapor pressure, viscosity, volatility, Newtonian fluid, basics of rheology. Crystal and amorphous state; characteristics, determining the structure of crystals. Solutions, colligative properties, crioscopia, ebulioscopia, osmosis, osmotic pressure, diffusion, dissolution of liquid in the liquid phase (fractional distillation, Azeotropic mixture of liquids that are mutually partially soluble, mutual non-mixable liquids). Phase equilibria and transformations of Gibbs's rule stage, thermal analysis of single-component and two-component systems. Phenomena at interfaces: adsorption on the surface of the solid and liquid phases, surface tension, capillary phenomena. Colloidal state: structure, types, obtaining, kinetic, electrical, optical and rheological properties, purification, determination of molecular weight and concentration of colloid stability. Chemical kinetics, order of reaction, and parallel chain reactions, homogeneous and heterogeneous catalysis. Fundamentals of radiochemistry: nucleus, isotopes, isotope separation by mass spectrography, radioactive decay, natural and artificial radioactivity. Fundamentals of acoustics. Electricity. Magnetic field. Electromagnetic induction. Electrical oscillations and electromagnetic waves. Optics. Laser. X-ray radiation.Practical classesDetermination of the coefficient of viscosity. Determination of the coefficient of surface tension. Determination of the pitch with the resonator. Determination of the reaction order. Crioscopia. Determination of Gibbs and Froindlich's adsorption of isotherm. Ohm's law. Winston's bridge. Poggendorff's method of compensation. Calorimetry. Determination of the focal length of the lens. Determination of refractive index of liquids. Microscope (magnification lens and aperture number). Computational exercise: The dynamics of liquids and gases. Waves and Sound. Thermal expansion. Geometrical optics. Basic physics of the atom. Computer simulations of the experiment.Literature: 1. Ristovski LJ., Burić N.: Fizika, Službeni list SRJ, Beograd, 2000.2. Malešev D.: Odabrana poglavlja fizičke hemije, izd. Malešev D., Beograd, 2003.3. Medenica M., Malešev D., Eksperimentalna fizička hemija, izd. Medenica M., Beograd, 2002.4. Kuntić V., Aleksić M., Pavun L., Pejić N.: Zbirka zadataka iz fizičke hemije, izd. Pavun L., Beograd, 2003.5. Atkins, P. W., Physical Chemistry, Oxford University Press, New York, 2002.6. Holclajtner Antunović I.: Opšti kurs fizičke hemije, udžbenik, Zavod za udžbenike i nastavna sredstva, Beograd, 2000.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, interactive teaching demonstrations, computer simulations, exercises.



BIOLOGY WITH HUMAN GENETICS

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Biology with Human GeneticsTeacher: Subjects status: compulsorySemester: first year, first semesterECTS: 3Requirement: noSubjects objective: To familiarize students with basic knowledge of cell, with special emphasis on the importance of genetic factors in its functioning.Subjects outcome: Course outcomes: After completing this course, the student should be able to: master the technique of microscopy, describe and explain the structure and function of the cell as the basic unit of structure of the body, understand the

organization of the processes in cytoplasm and in nucleus of cells, describe and explain the transfer of information from DNA through RNA to protein, understand and explain the mechanisms of mutations of genetic material (genotype) and link these changes with the appropriate phenotype, apply the acquired knowledge in Biology and Human Genetics at other biomedical subjects during the studySubjects content: Lectures The concept of the subject, the importance for students of pharmacy. The methodology of research in cell biology and genetics. Basic characteristics of eukaryotic cells. The evolution of cell. The chemical composition of cells and metabolism. Organization of eukaryotic cells. Hereditary basis and its function. Changes in the structure of genes and chromosomes. Cell cycle and cell death. Gametogenesis, fertilization, and developmental biology. Mutations of genes and chromosomes. DNA and gene expression. DNA repair mechanisms. Immunobiology. Oncogenetics. The molecular basis of human diseases. Pharmacogenomics. The methodology of research in cell biology and geneticsPractical classes Microscope and microscopy techniques. The size and shape of cells and nuclei, embryonic origin of cells. Plasma membrane. Cytoplasmic organelles. Interphase nucleus, chromatin. Cell division: mitosis and meiosis. Transcription and translation. Chromosomal aberrations and gene mutations.Literature:1. Hristić M. Potparević B. Practicum in Biology and Human Genetics, Faculty of Pharmacy, Belgrade, 2005.2. Diklić V. Kosanović M., S. Dukić, Nikolić J.: Biology and Human Genetics, Grafopan, Belgrade, 2,001th3. Delic, N., Stanimirović Z.: Principles of genetics, Elite Medica, Belgrade 2004.4. Bruce Alberts. Molecular Biology of the Cell, 5th ed., Garland Science, New York, 2008.5. Nussbaum R. L., R. McInnes R. Willard H. F.: Genetics in Medicine, 7th ed., Saunders, Philadelphia, 2007.Number of active teaching: Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, practical exercises.


Lectures 5 Exame 60Practical classes 15Colloquiums 20Seminars 0ANATOMY

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studies Name of subject: AnatomyTeacher: Subjects status: compulsorySemester: first year, first semester ECTS: 3Requirement: noSubjects objective:Understanding the normal anatomical and histological structures and concepts.Subjects outcome: The ability to define, understand, describe, integrate and reproduce terms related to the normal anatomical and histological structure. Subjects content:Lectures: Basic anatomical terms. Body parts. Upper extremity. The bones, joints, muscles, blood vessels and nerves. The lower extremity. The bones, joints, muscles, blood vessels and nerves. Thorax. The walls of division and the thoracic contents. Lung tissues. Heart. The bodies of the mediastinum. Abdomen. The walls of division and abdominal contents Peritoneum. Peritoneal cavity (liver, stomach, spleen, pancreas, small and large intestines). Retroperitoneal space (kidney, adrenal glands, aorta, inferior vena cava, celiac plexus). Pelvis. The walls and contents. Bladder, anus bowel, male and female sex organs. Pelvic rungs. Head and neck. Bones of the head and face. The muscles of the head and neck. Large blood vessels

and nerves of the head and neck. Central nervous system.Practical classes Practical teaching demonstration of all units on anatomical models. Using the atlas. Video presentations.Literature: 1. Mihalj M.: Anatomija čoveka, Zmajeva biblioteka izdanja, Novi Sad, 2005. 2. Bošković M.: Anatomija čoveka, deskriptivna i funkcionalna, Medicinska knjiga, Beograd, 1973.3. Mačvanin Đorđe: Anatomija, udžbenik, Fakultet za menadžment u sportu, Alfa univerzitet, Beograd, Matica srpska, Novi

Sad, 2005.4. Pajić D., Mačvanin Đ. i sar.: Hirurgija, odabrana poglavlja, udžbenik, Medicinski fakultet, Novi Sad, Matica srpska,

Novi Sad, 2009.5. Milisavljević M. i sar.: Klinička anatomija, Nauka, Beograd, 2004.6. Netter F. H., Machado, C. A. G.: Atlas of Human Anatomy & CD, ILS, Mala velika knjiga, Novi Sad, 2005.Number of active teaching: Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:Lectures and practical exercises with anatomical and hitološkim preparations, the use of the atlas, video projections.



General Chemistry

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: General Chemistry Teacher:Subjects status: compulsorySemester: first year, first semesterECTS: 9Requirement: noSubjects objective:Students acquire basic knowledge of general chemistry necessary for mastering in the basic and applied chemical sciences: analytical, physical and pharmaceutical chemistry, drug analysis. Basic knowledge of general chemistry include understanding chemical concepts, theories and principles, knowledge of laws, rules and principles of chemical calculations, understanding of chemical reactions and the influence of intermolecular interactions on the states of matter.Subjects outcome: After passing the exam, the student is able to: develop analytical thinking to solve chemical problems, perform all kinds of calculations in chemical (galenic) lab, predict and analyze the course of chemical reactions, the application of basic chemical principles and laws of the understanding of chemical processes in chemical systems, plans and organize work in a chemical lab, apply the acquired knowledge to the study of pharmacy in higher yearsSubjects content:LecturesMatter and energy. Systematic nomenclature. Stoichiometric calculations. Periodic table of the elements. The structure of the atom. Chemical bond theory and chemical bonding. Intermolecular connection. Solutions. The quantitative composition of the solution. Colligative properties of solutions. Acids, bases and amphoteric electrolytes. Theories of acids and bases. The activity of ions. Chemical reactions. Chemical equilibrium. Equilibria in solutions of acids and bases. pKa values. pH in solutions of acids and bases. Equilibria in aqueous salt solutions. Buffers. Equilibria in heterogeneous systems. Solubility product constant. Oxidation-reduction. Electrochemical cells and reduction potentials. Complex compounds. Practical classesChemical Laboratory, functions and equipment; chemical laboratory safety and basic laboratory techniques. Solutions. Calculation and measurement of pH in aqueous electrolyte solutions. Buffers. Analysis of elements’ reactivity and inorganic compounds relevant to the field of pharmacy.

Literature: 1. Perišić-Janjić N., Đaković-Sekulić T., Gadžurić S.: Opšta hemija, Univerzitet u Novom Sadu, 2008.2. Čakar M., Popović G., Opšta hemija I, udžbenik, Farmaceutski fakultet, Beograd, 2005.3. Češljević V. I., Leovac V.M., Praktikum opšte hemije, Prirodno-matematički fakultet, Novi Sad, 2005.4. Šuranji T., Jovanović Lj., Zbirka zadataka, Prirodno-matematički fakultet, Novi Sad, 1995.5. Whitten K. W., Davis R. E., Peck M. L., General Chemistry, Saunders College Publishing, Philadelphia, 2000.6. Kotz J., Treichel P., Chemistry and Chemical Reactivity, Saunders College Publishing, Philadelphia, 1999.7. Filipović I., Lipanović S., Opća i anorganska hemija, Školska knjiga, Zagreb, 1985.Number of active teaching: Other classes:Lectures: 90 Exercises: 75 Other forms of teaching: Students research work:Methods of teaching:lectures, practical classes, discusions, solving problems.



Organic Chemistry I

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Organic Chemisrty ITeacher:Subjects status: compulsorySemester: first year, first semesterECTS: 9Requirement: noSubjects objective:Gaining knowledge about building links, types of hybridization and electronic effects in organic compounds, introduction to the basic classes of organic compounds (systematic naming, structure, and reactivity), exploring the types and mechanisms of ionic and radical reactions characteristic of organic compounds.Subjects outcome: Gaining knowledge about the structure and reactivity of organic compounds, understanding the mechanisms of organic reactions, making elementary logical framework for the interlinked structure and function of organic molecules.Subjects content:LecturesStructure, types of connections, the electronic effects in organic molecules. Hybridization. The acidity and basicity of organic compounds. Stereochemistry, working with models. Nomenclature, physical properties, chemical properties, reaction mechanisms characteristic and application of the basic classes of organic compounds: alkanes, cycloalkanes, alkenes, alkadieni, alkynes, aromatic compounds, alkyl halides, aryl halides, alcohols, phenols, ethers, tioalkoholi, thioethers, carbonyl compounds, carboxylic acids, substituted carboxylic acid derivatives of carboxylic acids, amines, nitro compounds.Practical classesNomenclature, physical properties and chemical properties of the main classes of organic compounds: alkanes, cikloalkani, alkenes, alkadieni, alkynes, aromatic compounds, alkyl halides, aryl halides, phenols, alcohols, ethers, tioalkoholi, thioethers, carbonyl compounds, carboxylic acids, substituted carboxylic acid derivatives of carboxylic acids, amines, nitro compounds.Literature: 1. Vollhardt K. P., Schore N. E., Organic chemictry, 2. ed., Haidigraf, Belgrade, 1996.2. Pine H. Stanley, Hendrickson B.James, Cram J. Donald, Hammond S. George: Organic chemistry, School book, Zagreb,

1984.3. Dewick M. Paul: Essentials of Organic Chemistry: For Students of Pharmacy, Medicinal Chemistry and Biological

Chemistry, 1st ed., Willey, New York, 2006.

4. Morison R., Вoyd R., Organic chemistry, 6th ed., Prentice Hall, Harlow, 1992.5. Đurendić E., Velimirović S., Ćirin Novta-V.: Practicum of Organic chemistry, 3rd ed.., Faculty of Science, Novi Sad,

2004.Number of active teaching: Other classes:Lectures: 105 Exercises: 60 Other forms of teaching: Students research work:Methods of teaching:lectures, exercises, work with models, discusions.



HISTOLOGY

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studies Name of subject: HistologyTeacher:Subjects status: compulsorySemester: first year, second semesterECTS: 2Requirement: noSubjects objective:Mastering the use of microscope and learning the fundamental features of normal cell structure of tissues and organs, which makes morphological foundation necessary to understand all the vital processes in the body, with particular emphasis on the knowledge of the cell types that are the target of action of pharmacological substances (muscle cells, nerve cells, marginal cells), metabolic products of cells that are used as active pharmacological substances (hormones, neurotransmitters) and cells through which drugs are absorbed, secreted or degraded (enterocytes, nephrocyte, hepatocytes).Subjects outcome: Introduction to basic micromorphological and functional characteristics of normal structure of cells, tissues and organs.Subjects content:LecturesBasic microscopic methods. General characteristics of the structural organization of the cell. General characteristics and division of tissue. Epithelial, connective, muscle and nervous tissue. Hematopoietic organs and blood. Limfopoezni (lymphatic) organs. Cardiovascular system. Respiratory system. The digestive system. The urinary system. Male and female reproductive systems. Nervous system. The endocrine system. Skin and sensory organs.Practical classes Forms of cells and nuclei, covering epithelium. Connective tissue (loose connective tissue, white adipose tissue, bone tissue). Muscle tissue (smooth, skeletal and cardiac). The nervous system (cerebrum, spinal cord, peripheral nerves). Blood (blood smear: erythrocytes, leukocytes, platelets). The cardiovascular system (muscular type arteries and veins). The immune system (palatine tonsil, lymph node). The endocrine system (pituitary gland, thyroid gland, adrenal gland). The respiratory system (trachea, lungs). The digestive system (tongue, stomach, duodenum, liver, pancreas). The urinary system (kidneys). Male and female reproductive system (testis, ovary, uterus).Literature: 1. Trpinac D.: Histologija za studente farmacije, Kuća štampe, Beograd, 2001.2. Trpinac D., Obradović M.: Repetitorijum histologije i embriologije, Medicinski fakultet, Beograd, 2005.3. Trpinac D.: Praktikum za histološke exercises za studente farmacije, Farmaceutski fakultet, Beograd, 2005.4. Belić P., Mačvanin Đ., Šarac D.: Nova koža, udžbenik, Medicinski fakultet, Novi Sad, 2000.Number of active teaching: Other classes: Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:Lectures, Working with the statistical software package, resolution of examples from pharmacy practice, e-learning.



BOTANY

Study programes: pharmacyType and level of study: integrated academic studies Name of subject: BotanyTeacher: Subjects status: compulsorySemester: first year, second semesterECTS: 7Requirement: noSubjects objective:Make students familliar with basic knowledge of morphology, anatomy, physiology and ecology of plants important for pharmacy learning about the classification systems as information systems, knowledge of a select group of medicinal plants, application of acquired knowledge in problem botanical herbs and other useful plants. Subjects outcome:After completing the course student should be able to: describe and explain the morphological and anatomical characteristics of plant organs and tissues, identify them macroscopically and microscopically, describe and explain the basic physiological processes of plants, be aware of environmental principles, determines the group correctly identified, named, described and classify species predict plant properties based on their systematic identification, access information using literature and electronic databases.Subjects content:LecturesThe position and role of plants in the system of organisms and their significance to pharmacy. Physical organization of plants. Basic characteristics of plant cells. Basic features of the anatomy of plants. Plant tissue: dermal and parenchymal tissues. Mechanical and conductive tissues, consignment bundles. Basic concepts of plant physiology, plant water regime. Photosynthesis, respiration and mineral nutrition. Secretory structures of plants. Products of metabolism. Anatomy of root, stem and leaf. Nomenclature, taxonomy and classification systems of plants. Summary biosystematic group of plants. Fungi, algae, lichens, mosses, horsetail, fern. The morphology of vegetative and reproductive organs of seed coat. Gymnosperms, Angiosperms. Dikotile, monocots. Botany and Biotechnology. Fundamentals of ecology of plants. Natural populations of medicinal plants: knowledge, potential use and protection. Plant species in the territory of SerbiaPractical classesMicroscopic analysis of the characteristics of plant cells. Microscopic analysis of plant tissues. Microscopic identification of vegetative plant organs. Morphological analysis of vegetative organs. Morphological analysis and miroskopska reproductive structures. Methods of determination of higher plants. Using the literature and databases. Biosystematic groups of plants important for pharmacy. Selected representatives of deciduous Angiosperms and relevant to pharmacy. Plant species in the territory of Serbia. Excursion.Literature:1 Jančić R.: Botany pharmaceuticals, Gazette, Belgrade 2008.2 Lakušić B. Slavkovska V. Stojanovic, D.: Manual for exercises for students of Botany, Faculty of Pharmacy, Faculty of

Pharmacy, Belgrade, 2005.3 Tatic, B., V. Blečić, systematics and phylogeny of higher plants, textbook, Institute for Textbooks and Teaching Aids, Bel -

grade, in 1984.4 Stojanovic S.: Botany, auxiliary textbook for students of the Faculty of Agriculture, Univer. of Novi Sad, 1995.5 Stojanovic S.: Biology, ecology and control of weeds, tutorial, University of Novi Sad in 1995.6 Neškovic M. Konjevic R. Ćulafić Lj.: Plant Physiology, NNK International, Belgrade 2003.7 Stevanovic B, Jankovic M. Ecology of plants with the basics of physiological ecology of plants, NNK International, Bel-

grade, 2001Number of active teaching: Other classes:Lectures: 45 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:

lectures, Practical classes (individual, in pars in groups), problem cases, field trip lessons. Grading (maximum 100 points)

Pre-Exame commitments Points Final Exame PointsLectures 5 Exame 50Practical classes 30Colloquiums 15Seminars 0

INORGANIC CHEMISTRY

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Inorganic Chemistry Teacher:Subjects status: compulsorySemester: first year, second semesterECTS: 3Requirement: General ChemistrySubjects objective:Getting basic knowledge in inorganic chemistry that are needed to overcome the program applied chemical disciplines such as pharmaceutical chemistry, analytics drugs, bromatology and toxicology. Subjects outcome: Students are able to apply their knowledge to the evaluation of chemical properties of inorganic substances, to predict and analyze the course of chemical reactions involving inorganic compounds, to apply the acquired knowledge to study pharmacy at higher university levels.Subjects content:LecturesPrevalence of of chemical elements in nature. Systematic study of the elements of the main groups and sub-groups of the periodic table of elements and their compounds. Location and characteristics of the elements in the periodic table. Hydrogen. The noble gases. Non-metal, non-metal compounds with hydrogen and oxygen. Oxoacids. Metals. Binary compounds. Acid-base properties and solubility of oxides and hydroxides. Salts and complex compoundsPractical classesAnalysis of the reactivity of elements and inorganic compounds relevant to the field of pharmacy.Literature: 1. Bresjanac M., Neorganska hemija, udžbenik za studente farmacije, Grafopan, Beograd, 2001.2. Filipović I., Lipanović S., Opća i anorganska kemija, Školska knjiga, Zagreb, 1985.3. Poleti D.: Opšta hemija, II deo - Hemija elemenata, udžbenik, Tehnološko-metalurški fakultet, Beograd, 2000.4. Arsenijević S. R.: Hemija opšta i neorganska, udžbenik, Naučna knjiga, Beograd, 1994.5. Leovac V. M., Češljević V. I., Sovilj S.: Praktikum neorganske hemije, I deo, Prirodno-matematički fakultet, Novi Sad,

2006.6. Šuranji T., Jovanović Lj., Zbirka zadataka, Prirodno-matematički fakultet, Novi Sad, 1995.Number of active teaching: Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, practical classes, discusions, solving problems.



Physical Chemistry

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studies

Name of subject: Physical ChemistryTeacher: Subjects status: compulsorySemester: first year, second semesterECTS: 4Requirement: noSubjects objective:After completing this course, the student should acquire a fundamental knowledge of physical chemistry necessary for understanding the physical and chemical processes important for vocational subjects, for example: pharmaceutical technology, biopharmacy, analysis of drugs, pharmacokinetics, pharmaceutical chemistry, etc., and to gain understanding of the basics of instrumental methods.Subjects outcome:Students understand the physico-chemical processes of importance in pharmacy and biochemistry. It can track all theoretical, methodological, technical, professional and applicative subjects requiring knowledge of certain physicochemical processes.Subjects content: LecturesChemical Thermodynamics: Laws of thermodynamics, functions of the system, thermo chemistry, chemical affinity, the equilibrium in homogeneous systems, the chemical potential. Liquefaction: vapor pressure, viscosity. Crystal and amorphous state. Solutions: dissolution of solid in the liquid phase, Colligative properties, cryoscopy and ebullioscopy, osmosis and osmotic pressure, diffusion, dissolution of fluids (completely miscible, fractional distillation, Azeotropic mixtures, partially or completely non-mixable). Phase equilibrium and transformations, Gibs phase rule, thermal analysis. Phenomena at interfaces: adsorption on the surface of the solid and liquid phases, surface tension, capillary phenomena, physico-chemical principles of chromatographic separation and chromatography. Fundamentals of colloid chemistry: kinetic, electrical and optical properties of colloids. Chemical kinetics in homogeneous and heterogeneous systems, speed and molecularity of reaction, determination of order of reaction, parallel and chain reactions, catalysis, photochemical reactions, fundamentals of radiochemistry.Practical classesLiquefaction: determination of the coefficients of viscosity and surface tension. Chemical kinetics: determination of reaction order. Phase transformation: cryoscopy. Phenomena at interfaces: determination of Gibbs and Freundlichs adsorption isotherms, basic chromatographic techniques. Chemical Thermodynamics: Calorimetry.Literature: 1. Malešev D.: Selected Topics in Physical Chemistry, vol. Malešev D., Belgrade 2003.2. Medenica M. Malešev D., Experimental Physical Chemistry, vol. Medenica M., Belgrade 2002.3. Kuntić V., M. Aleksic, Pavun L., N. Pejic, Problems in Physical Chemistry, vol. Pavun L., Belgrade 2003.4. Atkins P.W., Physical Chemistry, Oxford University Press, New York, 2002.5. Holclajtner Antunovic I.: General course of physical chemistry textbook, Institute for Textbooks and Teaching

Aids, Belgrade, 2000.6. Glasstone Samuel: Physical Chemistry, Scientific Book, Belgrade, in 1967.7. Barker Susan, Antonijevic Milan et al.: Solid State Characterisations of Pharmaceuticals (eds: Richard A. Story,

Ingvar ymen), Wiley, New York, 2011.Number of active teaching: Other classes:Lectures: 45 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, laboratory exercises.



Analytical Chemistry I

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studies

Name of subject: Analytical Chemistry ITeacher: Subjects status: compulsorySemester: first year, second semesterECTS: 6Requirement: General ChemistrySubjects objective: Providing students with necessary methodical foundation (both theoretical and practical) of qualitative chemical analysis as a basis for further understanding and application in other chemistry disciplines. Providing balanced knowledge on key analytical concepts and pallication of analytical methods.Developing practical skills to apply standard methodology in solving problems during analytical chemistry course, as well as in further education or in profession.Subjects outcome:After sucessfull completuion of the course, a student is able to: list and explain procedures and applications of analytical methods in modern chemistry and in contemporary environment, demonstrate acquired knowledge and understanding of the basic facts, terms, principles and theories of qualitative chemical analysis, identify cations and anions present in a sample, applying standard separation techniques, and analyze data obtained by qualitative analysis of mixtures, apply appropriate laboratory procedures in solving practical problems in qualitative analysis of the given samples, adequately operates the basic aquipment in the analytical laboratory, safely handles the reagents and knows potential hazards and risk assessment in practical work. independently draws conclusions and writes reports on the results of the qualitative analysis.Subjects content: LecturesBasic principles, topics and branches of analytical chemistry. Qualitative chemical analysis and analytical reactions. Acid-base equilibria in analytical chemistry. Complex equilibria in analytical chemistry. Precipitation in qualitative analysis. Systematic qualitative analysis of cations. Redox reactions in analytical chemistry. Qualitative analysis of anions. Qualitative analysis of selected materials. Chromatography in qualitative analysis.Practical classesSystematic cation analyis. Analysis of anions. Qualitative inorganic analysis of selected ions in medicaments and pharmaceutical products. Chromatography in qualitative analysis. Analysis of unknown sample.Literature: 1. Kapetanović V., Jelikić-Stankov M.: Analitička hemija i uvod u semimikrokvalitativnu hemijsku analizu, udžbenik, Uni-

verzitet u Beogradu, 1998.2. Jelikić-Stankov M., Kapetanović V., Karlјiković-Rajić K., Aleksić M., Ražić S., Uskoković S., Odović J.: Semimikro

kvalitativna hemijska analiza, praktikum za studente farmacije, udžbenik, Tehnološko-metalurški fakultet, Beograd, 2004.

3. Mesaroš-Sečenji K., Žigrai I.: Osnovi analitičke hemije, udžbenik, Univerzitet u Novom Sadu, 2000.

4. Šuranji T., Jovanović Lj., Zbirka zadataka, Prirodno-matematički fakultet, Novi Sad, 1995.5. Rondović D.: Kvalitativna hemijska analiza, Naučna knjiga, Beograd, 1991.6. Kaličanin B., Velimirović D.: Praktikum iz analitičke hemije za studente farmacije, Medicinski fakultet, Niš, 2007.7. Skoog Douglas A., Holler F. James, West Donald M.: Osnove analitičke kemije, Školska knjiga, Zagreb, 1999.Number of active teaching: Other classes:Lectures: 30 Exercises: 45 Other forms of teaching: Students research work:Methods of teaching:lectures, laboratory exercises, work in groups.


Lectures 5 Exame 50Practical classes 30Colloquiums 15Seminars 0Organic Chemistry II

Study programes: pharmacyType and level of study: integrated academic studies

Name of subject: Organic Chemistry IITeacher: Stojanovic Srdjan PhDSubjects status: compulsorySemester: first year, second semesterECTS: 7Requirement: Organic Chemistry ISubjects objective:The goal of course is to acquire knowledge of the stereochemical properties of molecules; stereohemijskih understanding of the characteristics of organic reactions, acquisition of knowledge about the structure and general properties of heterocyclic compounds stereohemijskih understanding of the characteristics of monosaccharides; mastering the technique of basic laboratory operations in multiphase organic synthesis.Subjects outcome:After passing the subject, the student is able to: understand and recognize stereohemijskih properties of organic compounds and chemical transformation, understanding the structural characteristics, reactivity and properties of heterocyclic compounds and carbohydrates, and knowledge of basic laboratory techniques of multiphase organic synthesis.Subjects content:Lectures:Stereochemistry, working with models. Stereoisomerism, elements of symmetry, chirality, nomenclature, enantiomers, optical activity, configuration, compounds with multiple chiral S-atoms, racemic forms, extract and separation of the racemate, the conformation of acyclic compounds, cyclic compounds, stereochemistry, conformation of unsubstituted and substituted six-membered rings, the structure and chirality Allen, stopping and biphenyls, Stereoselective and stereospecific reactions, asymmetric synthesis, prohiralna compounds, Cram's rule. Heterocyclic compounds: nomenclature, physical and chemical characteristics, aromaticity, heteroatom effect on reactivity, acidity, alkalinity, refined, condensed polycyclic derivatives. Carbohydrates: Definition, nomenclature, classification, response, and reducing the number of the extension, cyclic structure of monosaccharides, mutarotacija, anomerni effect, glycosides, esters, ethers, carbohydrates, disaccharides, polysaccharides.Practical classes: Theoretical exercises of stereochemistry, preparation of the experimental preparation.Literature: 1. Mihailovic M.: Basics of theoretical organic chemistry and stereochemistry, textbook, book building, Belgrade, in 1975.2. Eliel Ernest Ludwig: Basic Organic Stereochemistry, 1st ed., Wiley, New York, 2001.3. Paul S.: Introduction to the Chemistry of heterocyclic compounds, Scientific Book, Belgrade, 1997.4. Joule J. A., Smith G. F., Joule John Arthur: Heterocyclic Chemistry, 5th ed., Wiley-Blackwell, New York, 2010.5. Pine H. Stanley, Hendrickson B.James, Cram J. Donald, Hammond S. George: Organic chemistry, School book, Zagreb,

1984.6. Vollhardt K. P., Schore N. E., Organic chemistry, 2. ed., Haidigraf, Belgrade, 1996.Number of active teaching: Other classes:Lectures: 45 Exercises: 45 Other forms of teaching: Students research work:Methods of teaching: lectures, laboratory exercises, group exercises, Work with models.



Analytical Chemistry II

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Analytical Chemistry IITeacher:Subjects status: compulsorySemester: second year, third semester

http://www.amazon.com/Heterocyclic-Chemistry-John-A-Joule/dp/1405133007/ref=sr_1_1?s=books&ie=UTF8&qid=1334135503&sr=1-1

http://www.amazon.com/John-Arthur-Joule/e/B0034P7VPA/ref=sr_ntt_srch_lnk_1?qid=1334135503&sr=1-1

http://www.amazon.com/G.-F.-Smith/e/B00288MV8G/ref=sr_ntt_srch_lnk_1?qid=1334135503&sr=1-1

http://www.amazon.com/J.-A.-Joule/e/B001IXTW20/ref=sr_ntt_srch_lnk_1?qid=1334135503&sr=1-1

ECTS: 8Requirement: Analytical Chemistry ISubjects objective:Providing a wide and balanced theoretical and practical knowledge of key analytical concepts in quantitative analysis. Providing the necessary methodological basis in the field of quantitative analysis as a basis for further understanding and application in other fields of chemistry. Developing practical skills and ability to apply standard methodologies and good laboratory practice in solving problems in analytical chemistry in further chemical education, and later in the profession.Subjects outcome:After completion of this course, student is able to: specify application of methods of quantitative analysis in contemporary society, demonstrate acquired knowledge and understanding of basic facts, concepts, principles and theories of qualitative analytical chemistry in solving basic familiar and unfamiliar analytical problems, formulate conclusions on the basis of collection and interpretation of volumetric and gravimetric results and write report on the conducted analysis, apply mathematical and statistical knowledge and computer skills in error analysis in the quantitative analytical experiments, handle with equipment and apply simple computer software or models in processing experimental data.Subjects content:LecturesQuantitative chemical analysis, volumetric analysis: measuring mass and volume. Errors in quantitative analysis. Acid–base titrations. Complexometric titrations. Oxido-reduction methods. Precipitation titrations. Gravimetric analysis, operations in gravimetric analysis, gravimetric determination. Instrumental endpoint detection.Practical classesLaboratory exercises are in accordance with the theoretical syllabus.Literature: 1. Žigrai I., Šuranji T.: Osnovi kvantitativne hemijske analize, I deo, udžbenik, Univerzitet u Novom

Sadu, 2005.2. Žigrai I.: Osnovi kvantitativne hemijske analize, II deo, udžbenik, Stylos, Novi Sad, 1995.3. Šuranji T.: Praktikum za kvantitativnu hemijsku analizu, Univerzitet u Novom Sadu, 1999.4. Savić J., Savić M.: Osnovi analitičke hemije, klasične metode, udžbenik, Svetlost, Sarajevo, 1989.5. Skoog Douglas A., Holler F. James, West Donald M.: Fundaments of Analytical Chemistry, 6th ed., Saunders College

Publishing, Philadelphia, 1996. 6. Gary D. C.: Analytical Chemistry, John Wiley & Sons, New York, 2004. 7. Jelikić-Stankov M., Kapetanović V., Karlјiković-Rajić K., Aleksić M., Ražić S., Uskoković-Marković S., Odović J.:

Kvantitativna hemijska analiza, praktikum i zbirka zadataka za studente farmacije, Tehnološko-Metalurški fakultet, Beograd, 2004.

8. Thomas M.: Analytical Chemistry by Open Learning: Ultraviolet and Visible Spectroscopy; Quality in the Analytical Chemistry laboratory, 2nd ed., John Wiley & Sons, New York, 1996.

Number of active teaching: Other classes:Lectures: 30 Exercises: 45 Other forms of teaching: Students research work:Methods of teaching: lectures, laboratory exercises, demonstrations.



Instrumental Pharmaceutical Analysis

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Instrumental Pharmaceutical AnalysisTeacher: Subjects status: compulsory

Semester: second year, third semesterECTS: 5Requirement: General ChemistrySubjects objective: Introduce students to the theoretical principles, devices, and how performance capabilities of different instrumental methods that will be used in later years of study and work in labs where pharmacists. For practical classes - the student masters the selected instrumental methods.Subjects outcome:The student is trained (theoretical and practical) to automatically select the appropriate instrumental method according to the task, and in accordance with the specifics of the pharmaceutical profession. Who is able to help with the instructions, the device also done independently given experiment.Subjects content:LecturesPrinciples and classification of instrumental methods. Signal detection and response. Measuring devices. Spectrochemical methods. Electromagnetic radiation, photocells. Instrumental methods based on the rotation and refraction of light. Absorption and emission of radiation. Lambert-Beer's law. Atomic absorption and emission spectroscopy. X-ray spectra. Molecular spectroscopy, absorption of UV, VIS and IR radiation absorption and emission spectrometry. Methods based on light scattering. Mass spectrometry. Electrochemical methods. Electrolytes, conductivity, Dubai Hick's theory, Kohlrausch's law, conductivity measurement, calculation and constant degree protolize, the electrophoretic effect, Calorimetry and conductometric titration. Electrochemical cell electrode, and membrane diffusion potential, Nernst's potential, types of electrodes, pH-metry, ion-selective electrode potentiometry and potentiometric titration. Electrolytic cell, coulometry. Polarization and depolarization electrodes, polarography. Instrumental methods of separation. Separation techniques based on the principle of adsorption, dissolution, ion exchange, and charge mobility of the particles. Gas and liquid chromatography. Electrophoresis. Elektrohromatografija.Practical classesAbsorption spectrometric methods (atomic and molecular). Methods emission spectrometry (atomic and molecular). Methods based on the scattering of electromagnetic radiation (nephelometry). Polarimetry. Refractometry. Coulometry. Polarography. Calorimetry and conductometric titrations. Potentiometry and potentiometric titration of various chemical systems. pH-metry. The chosen separation method.Literature: 1. Todorović M., Đurđević P., Antonijević V.: Optičke metode instrumentalne analize, udžbenik, Hemijski fakultet,

Beograd, 1998.2. Jovanović M., Jovanović V.: Elektroanalitička hemija, udžbenik, Tehnološko-metalurški fakultet, Beograd, 1991.3. Gužvanj Valerija: Praktikum iz instrumentalne analize, problemi i rešenja, Prirodno-matematički fakultet, Novi Sad,

2011.4. Brown B. H., Smallwood R. H., Barber D. C., Lawford P. V., Hose D. R.: Medical physics and biomedical engineering,

Inst. of Physics Publ., Bristol, Philadelphia, 1999.5. Limel F.: Elektrodijagnostika i elektrokardiografija, Školska knjiga, Beograd-Zagreb, 1991.6. Medenica M., Malešev D.: Eksperimentalna fizička hemija, izd. Medenica M., Beograd 20027. Skoog Douglas A., Holler F. James, West Donald M.: Osnove analitičke kemije, Školska knjiga, Zagreb, 1999.8. Kuntić V., Aleksić M., Pavun L., Pejić N.: Zbirka zadataka iz fizičke hemije, izd.: Pavun L., Beograd 2003.9. Antonović G. D.: Instrumentalne metode u organskoj hemiji, zbirka zadataka, Tehnološko-metalurški fakultet, Beograd,

2003.Number of active teaching: Other classes:Lectures: 45 Exercises: 60 Other forms of teaching: Students research work:Methods of teaching: lectures, Practical classes, demonstrations, exercises.



MOLECULAR CELL BIOLOGY

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Molecular Cell BiologyTeacher:Subjects status: compulsorySemester: second year, third semesterECTS: 3Requirement: Biology with Human GeneticsSubjects objective:The course teaches the students more familiar with the latest knowledge in the field of molecular and functional organization of the cell. Cource familiarizes them with the basic techniques used in this areaSubjects outcome:After completing the course, students should understand the principles underlying contemporary research in molecular cell biology, and be able to apply this knowledge in their future research.Subjects content:LecturesThe origin and evolution of the genetic system of the cell. Folding, processing, scheduling, control functionality, variability, degradation, and the emergence of new types of proteins. Molecular, structural and functional correlation between cell components: the cell membrane, cytoskeleton, organelle, nucleus, chromatin. Extracellular matrix and inter-cell communication. Architecture of nucleus (nuclear matrix, nuclear outfit, chromosomal territory) and its role in the expression of the genome. Evolutionary changes in the organization of the genome. Human genome. Reception and signal transduction in the cell, signaling molecules and their receptors, intracellular signal transduction pathways, communication signaling pathways, selectivity and specificity double-direct transport between the cytoplasm and the nucleus. Constitutive, inducible, tissue-specific and temporal gene expression. Regulation of gene expression at the transcription, post-transcription and post-translation level. Family of transcription factors, their roles and mechanisms of regulation of their activities. Structural modification of regulatory proteins: phosphorylation, glycosylation, ADP-ribosylation, ubiquinisation. Regulation of the cell cycle. The proliferation of cells during development and differentiation. Programmed cell death-apoptosis. Basic principles of genetic engineering, implementation and cloning.Practical classesPractical teaching is organized in the form of experimental and demonstration of audio-visual exercises. Organized visits to specialized laboratories in order to introduce students to the modern techniques in molecular biology.Literature: 1. Cooper M. Geoffrey, Hausman R.: Stanica: molekularni pristup (The Cell, a Molecular Approach; 2nd ed., ASM Press,

Washington, D.C, 2000.), Medicinska naklada, Zagreb, 2010.2. Kovačević Z. L.: Biohemija i molekularna biologija, udžbenik, Medicinski fakultet, Novi Sad, 1999.3. Alberts Bruce: Molecular Biology of the Cell, 5th ed., Garland Science, New York, 2008.4. Sambrook J., Green M. R.: Molecular Cloning: A Laboratory Manual, 4th ed., CSHL Press, New York, 2012.5. Lodish H., Berk A., Zipursky S. L., Matsudaira P., Baltimore D., Darnell J.: Molecular Cell Biology, 5 th ed., W. H. Freeman

& Co., New York, 2003.6. Lewin B.: Genes VII, Oxford University Press, New York, 2000.Number of active teaching: Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:interactive lectures, laboratory exercises, work in groups.



General Biochemistry

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: General BiochemistryTeacher: Subjects status: compulsorySemester: second year, third semesterECTS: 5Requirement: Organic Chemistry ISubjects objective:Students should gain basic knowledge of Biochemistry and understand the influence of Biochemistry on other fields of sciences. They should comprehend the connection between the structure and the biological function of biomolecules. Also, they should gain knowledge of structure and cell membranes` function, different metabolic pathways, inter-cell signaling, nucleic acids and biosynthesis of proteins. Students should understand the mechanism of enzyme activity, reactions of biotransformation of some exogenous and endogenous compounds.Subjects outcome: After students have successfully mastered the subject matter of this course, they are expected to be able to describe and analyze the main catabolic, anabolic and intermediate metabolic pathways, to apply knowledge of enzyme kinetics and inter-cell signaling in interpretation of metabolic pathways regulation in human body, to explain biochemical basis of protein synthesis, regulation and posttranslational modification of proteins, as well as to successfully apply gained knowledge so that they can easily follow and comprehend lectures of medicinal biochemistry.Subjects content:LecturesIntroduction: Structure and mechanism of enzymes and coenzymes activity, kinetics of enzyme and inhibition. Chemical composition of biological membranes and transport through a membrane. Main principles of bioenergetics. Catabolism of carbohydrates: Glycolysis, Glicogenolysis, Phosphogluconate pathway, catabolism of other hexoses. Catabolism of lipids: Oxidation Pathway of Fatty Acids, acylglycerols, phospholipids, sphingolipids, cholesterol. Catabolism of nitrogen’s compounds: Amino Acids, the Urea Cycle, proteins, nucleotides. Intermediary Metabolism Pathway: the Citric Acid Cycle, the Electron Transport Chain and Oxidative Phosphorylation. Anabolism of Carbohydrates: Gluconeogenesis, glycogenesis. Anabolism of lipids. Anabolism of nitrogen’s compounds. Inter-cell signaling: by the receptors which are bound to G-protein, enzymatic receptors, ion-channel receptors and nicotinic acetylcholine receptor. Biotransformation: Cytochrome P450 system, FM- monooxygenase, glucuronic acid conjugation, biotransformation of some exogenous and endogenous compounds. Biosynthesis of proteins and nucleic acids, replication, transcription, translation and post-translation modification of protein in human body.Practical classes Renewal of acquired knowledge about biomoleculs, structure and function of fibrillar (-collagen, -keratin) and globular proteins (hemoglobin and myoglobin), resolution of problems which are connected with kinetics of enzymatic reaction and enzyme inhibition, examples of some transport system disorders through the cell membrane, presentation of main metabolic pathways, resolution of some problems related to certain metabolic pathways, correlation of theoretical knowledge about metabolism with practical examples. Practical classes are partly performed in a lab.Literature: 1. Spasić S., Jelić-Ivanović Z., Spasojević-Kalimanovska V.: Opšta biohemija, udžbenik, Farmaceutski fakultet, Beograd,

2003.2. Topić A., Stanojević-Bogavac N., Kotur-Stevuljević J.: Laboratory exercises iz opšte biohemije, Farmaceutski fakultet,

Beograd, 2009.3. Mihajlović M.: Biohemija, udžbenik, Naučna knjiga, Beograd, 2000.4. Majkić-Singh N.: Medicinska biohemija, udžbenik, DMB SCG, Beograd, 2006.5. Kovačević D.: Biohemija, Savremena administracija, Beograd, 2003.6. Nelson D. L., Cox M. M.: Lehninger Principles of Biochemistry, Worth Publishers, New York, 2000.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:lectures, exercises, discusions, solving problems, work in labs.



ImmunologyStudy programes: pharmacy, pharm acy - medical biochemistryType and level of study: integrated academic studiesName of subject: ImmunologyTeacher:Subjects status: compulsorySemester: second year, third semesterECTS: 4Requirement: noSubjects objective: Introducing pharmacy students with: the inherent characteristics and acquired immunity and their effectoric mechanisms of defense against antigens of infectious microorganisms (bacteria, viruses, parasites and fungi); pathogenetic mechanisms and treatment of diseases caused by dysfunction of the immune system (hypersensitivity reactions, autoimmune diseases, caused by an excessive inflammatory reaction of the body, immune deficiency) immune response to antigens of non-infectious origin (tumor antigens and antigens grafts) and principles of immunotherapy and tumor immunotherapeutic strategies for the prevention of transplant rejection, immunomodulation of innate immune system disorders, principles and application of immunoassay based on the antigen- antibody reactionSubjects outcome: After passing the exam, the student will know effectoric mechanisms of innate and acquired immunity in the defense against infectious agents, known pathogenesis, the most important clinical manifestations and treatment of diseases caused by dysfunction of the immune system, know the immune response to tumors and transplanted tissue, as well as the principles of tumor immunotherapy and transplantation reaction, to master the principles of immunoassay for the qualitative and / or quantitative determination of antigens and antibodiesSubjects content:Lectures: Theoretical study: innate immunity. Assumption, processing and presentation of antigens. Antigen receptors on lymphocytes. The development of the immune repertoire. Cell-mediated immune response. Effectoric mechanisms of T-cell mediated immune response. The humoral immune response. Effectoric mechanisms of humoral immune response. Immunological tolerance: importance and mechanisms. Autoimmunity. The immune response to non-infectious antigens (tumors and transplants). Diseases caused by excessive inflammatory reaction of the body. Hypersensitivity diseases. Congenital and Acquired Immune Deficiency Syndrome (AIDS). Immunomodulation of innate immune system disorders.Practical classes Antigen, immunogen, hapten, immunization, obtaining polyclonal and monoclonal antibodies. Precipitation reactions. Agglutination reaction. Complement fixation test and the determination of total hemolytic complement activity (CH 50 test). Tests with radioactive bookmarks RIA, RIST, RAST. Tests with enzyme bookmark: ELISA, ELISA spot. Fluorochromes as bookmarks, immunofluorescence and flow cytometry. Immunohistochemistry. Methods for selective removal of cells. Methods for assessment of humoral and cellular immunity in vitro and in vivo. The tests that are performed before transplantation. Detection of immune complexes in tissues and biological fluids. The techniques of molecular biology in immunology.Literature: 1. Abbas Abul K., Lichtman Andrew H.: Osnovna imunologija - funkcionisanje i poremećaji imunskog sistema, 2. izd., Data

status, Beograd, 2007.2. Basta M. at al.: Immunology, Clinical Case Studies and Disease Pathophysiology (eds.: Strober W., Gottesman S. R. S.),

Hoboken, Wiley-Blackwell, New York, 2009.3. Basta M. at all: The Complement System; Novel Roles in Health and Disease (ed.: Szebeni J.), Kluver Academic Publishers,

Boston, Dordrecht, New York, London, 2004.4. Arsenović tyrant N. Stojic-Vukanic Z. Bufan B.: A Handbook for practical classes in immunology and immunochemistry,

Faculty of Pharmacy, Belgrade, 2007. Number of active teaching: Other classes:Lectures: 45 Exercises: 15 Other forms of teaching: Students research work:

Methods of teaching: lectures, Practical classes.



Physiology I

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Physiology ITeacher: Subjects status: compulsorySemester: second year, third semesterECTS: 4Requirement: noSubjects objective:Providing information in the field of physiology of cells, tissues, organs and systems of the whole body of man, important for the pharmaceutical profession and medical biochemists, and the role of the control mechanisms of the body. To know and understand the connection between the regulatory systems within the human body; provide the theoretical basis for monitoring and learning of other subjects.Subjects outcome: After completing the course and passing the exam, students are expected to: govern the relevant part of medical nomenclature, may explain the functioning of individual organs and organ systems, know and understand the integrated function of a number of individual organs, as well as the role of the control mechanisms of the body, know and understand the connection between regulatory systems within the human body, allowing adaptation of the organism to changes in the internal and external environment in everyday conditions.Subjects content:LecturesThe subject of the study of human physiology. Transport through the cell membrane. Intercellular communication. Physiology of excitation. Membrane resting potential. Action potential. Transferring nerve impulses. Physiology of striated muscle. Neuromuscular synapse. Morphophysiological characteristics of transversely striped muscle. Physiology of smooth muscle. Structure characteristics of different smooth muscle tissue types, innervation, electrical activity of smooth muscle contraction specificity. Organization of the nervous system. Nerve cells. Blood-brain barrier fluid, the composition and role. Spinal cord. Medulla oblongata midbrain. Functional characteristics, reticulo-cortical interrelations, decerebration rigidity and control of skeletal muscle tone. The cerebellum, the structure, function. Midbrain. The hypothalamus. The vegetative nervous system. The basal ganglia. Cortex. Senses. Definition, importance and general principles of sensory systems. The sense of hearing and balance. The sense of taste and smell. The sense of sight. The perception of pain. Introductory remarks in pathophysiology.Practical classes Membrane potentials and synaptic transmission. Patellar reflex and pupil. The influence of various factors on muscle shrinkage. Hemoglobin concentration, red blood cells and white blood cells in the blood of man. Buffering capacity of plasma. Coagulation of blood. Discussion and analysis of selected physiological systems. E-learning.Literature: 1. Despopoulos A., Silbernagl S.: Coloured physiological atlas for medical students, Medical faculty, Niš, 2007.2. Guyton A. C., Hall J. E.: Textbook of medical physiology, 11th ed., Savremena administracija, Belgrade, 2006.3. Marić D., Stojilković S.: General physiology, textbook for biology students, 2nd ed., Novi Sad University, 1991.4. Plećaš B.: Physiology handbook for pharmacy students, Faculty of pharmacy, Belgrade, 1996.5. Mujović and al.: Medical physiology, textbook, Medical faculty in Kosovska Mitrovica (Priština), 2004.6. Zgradić I., Maličević Ž.: Propaedeutics of muscles, bone-joint systems and nervs, Savremena administracija, Belgrade,

1996.7. Maličević Ž., Zgradić I.: Correlative neuroanatomy of skeletal muscles, textbook, Kragujevac University, 1999.8. Stanić V., Maličević Ž. and al.: Chest surgery (editor: Jaković R. M.), textbook, Medical faculty, Belgrade, 2004.

9. Harper H. A., Roodwell V.W., Mayes P. A.: Review of physiological chemistry, 16 th US ed., Savremena administracija, Belgrade, 1982.

10. Mihajlović Šćepović M, Veljković S, Ranković G, Radenković M, Cekić S, Veličković D, Nešić M, Veličković I, Branković S, Stojiljković N, Ćirić M, Pavlović V.: Physiology practicum for pharmacy students, Medical faculty, Niš, 2005.

Number of active teaching: Other classes:Lectures: 45 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, practical classes, computer animation and simulation of physiological processes.



PHARMACEUTICAL INORGANIC CHEMISTRY

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Pharmaceutical Inorganic ChemistryTeacher: Subjects status: compulsorySemester: second year, third semesterECTS: 4Requirement: Inorganic ChemistrySubjects objective:To provide students with knowledge about the basic principles of physico-chemical characterization of drug substances; applying knowledge of physical and chemical parameters in the analysis of relationships / structures, properties, effects and selectivity of the pharmaceutical active compounds, understanding of the basic principles of the mechanism of action of drugs at the molecular level; acquire basic knowledge of the principles of computer design drugs: gain knowledge of certain inorganic and organic-inorganic compounds.Subjects outcome: Students are expected to understand the mechanisms of action of drugs, analyzes relations between the structure, properties, effects and selectivity of the pharmaceutical active substances in order to design new and optimization of existing pharmaceutical active substances, applied computational methods to determine the chemical structure of drugs descriptors; apply knowledge of inorganic and organic-inorganic compounds of therapeutic importance.Subjects content:Lectures Introduction to pharmaceutical and medical chemistry; study of physical and chemical properties of ancillary and pharmaceutical active ingredients. Understanding the mechanism of action of drugs at the molecular level. Acquiring a basis for understanding the effects of drugs of appropriate pharmacological groups. The study of physical and chemical properties of pharmacologically active compounds: lipophilicity, solubility. Analysis of the ADME properties of drugs in the function of the design of new and existing optimization: absorption, distribution, metabolism and elimination. Molecular basis of the chemical mechanism of action of drugs: receptors and enzymes, active sites of drug actions, interactions of ligands and receptors, the binding affinity of the drug for the receptor. The basic principles of SAR (structure-activity relationship) QSAR, Stern and electronic effects, functional groups, molecular descriptors, QSAR models. The basic principles of designing drugs. The study of inorganic and organic-inorganic pharmaceutically active compounds. Preparation, physico-chemical properties, purity, biological and therapeutic significance. The chemical properties of pharmaceutical auxiliary substances: obtaining, physical-chemical properties, the degree of purity. Biological and therapeutic significance of inorganic and organic-inorganic compounds.Practical classes Coefficient of distribution. Analysis of physical properties (lipophilicity, solubility) and chemical properties of selected ancillary and pharmaceutical active ingredients. Nomenclature (exercise). The calculation of molecular descriptors of pharmacologically active substances. Degree of purity solving optimization problems involving drugs and designing new drugs. Discussion on the possible relationship of selected functional groups and activities compounds (SAR). Introduction to basic principles of molecular

modeling in the field of pharmaceutical drugs active inorganic compounds. Proposal for synthesis of selected active pharmaceutical inorganic compounds. Discussion of alternative procedures. The chemical properties of selected pharmaceutical ancillary substances: obtaining, physical and chemical properties, the degree of purity. Literature:1. Belae John M., Block John H.: Organic Medicinal and Pharmaceutical Chemistry, 12th ed., Lippincott Williams & Wilkins,

London, 2011 2. Radulović D., Vladimirov S.: Farmaceutska hemija I, udžbenik, Farmaceutski fakultet, Beograd, 2005. 3. Bothara K. G.: Inorganic Pharmaceutical Chemistry, Pragati Books Pvt. Ltd., Mumbai, 2008. 4. Discher A. Clarence, Medwick Thomas, Bailey C. Leonard: Modern Inorganic Pharmaceutical Chemistry, 2nd ed., Waveland

Pr Inc., New York, 1985. 5. Graham L. Patrick: Introduction to Medicinal Chemistry, 2nd ed., Oxford University Press, New York, 2001. 6. Williams D. A., Lemke T. L.: Foye's Principles of Medicinal Chemistry, 5th ed., Lippincott Williams & Wilkins, Baltimore,

2002. 7. Vujić Z., Brborić J., Čudina O., Erić S., Ivković B., Vučićević K., Marković B.: Priručnik za praktičnu nastavu iz

farmaceutske hemije I i II, Beograd, 2004

Number of active teaching: Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, interactive lectures, exercises.



Physiology II

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Physiology IITeacher: Subjects status: compulsorySemester: second year, fourth semesterECTS: 4Requirement: noSubjects objective:Providing information in the field of physiology of cells, tissues, organs and systems of the whole body of man important for the pharmaceutical profession and medical biochemists; provide the theoretical basis for monitoring and learning of other subjects.Subjects outcome: After completing the course and passing the exam, students are expected to: govern the relevant part of medical nomenclature, may explain the functioning of individual organs and organ systems, know and understand the integrated function of a number of individual organs, as well as the role of the control mechanisms of the body, know and understand the connection between regulatory systems within the human body, allowing adaptation of the organism to changes in the internal and external environment in everyday conditions.Subjects content:LecturesBlood. Properties of red blood cells, the role, the regulation of erythropoiesis. Iron metabolism. Hemoglobin. Blood group and Rh factor. Hemostasis and phase of anticoagulant substances. Heart. Functional characteristics and action potential of cardiac muscle. Regulation of cardiac function. Circulation. Hemodynamics. Arterial blood pressure, and control of it. Specific areas of circulation. Tissue fluid and lymph. Urinary tract. Kidney, renal blood flow. The processes of filtration. Reabsorption and secretion processes in the system of tubules. Primary and definitive urine. The role of the kidney in regulating plasma osmolality and volume of water in the body, the urine concentrating mechanism. Endocrine role of the

kidney. Respiration. Mechanics of breathing. Functional pulmonary circulation. Gas exchange in the lungs and tissues. Metabolic and endocrine role of the lungs. Digestion and absorption. Digestive juices and digestion of food. The mechanisms of absorption and transport of carbohydrates, protein, fat, water and electrolytes. Vitamins. Soluble and liposoluble vitamins. Their activation in the body and storing. Their physiological role. Liver. Skin. Endocrinology and reproduction.Hormones.Practical classesDetermination of heart rate and blood pressure. Auscultation of heart sounds. Control of cardiovascular function. Lung volumes and lung vital capacity (spirometry). Transport and exchange of gases, control of breathing. Digestive enzymes (ptyalin, pepsin) and bile.Literature: 1. Despopoulos A., Silbernagl S.: Coloured physiological atlas for medical students, Medical faculty, Niš, 2007.2. Guyton A. C., Hall J. E.: Textbook of medical physiology, 11th ed., Savremena administracija, Belgrade, 2006.3. Marić D., Stojilković S.: General physiology, textbook for biology students, 2nd ed., Novi Sad University, 1991.4. Plećaš B.: Physiology handbook for pharmacy students, Faculty of pharmacy, Belgrade, 1996.5. Mujović and al.: Medical physiology, textbook, Medical faculty in Kosovska Mitrovica (Priština), 2004.6. Zgradić I., Maličević Ž.: Propaedeutics of muscles, bone-joint systems and nervs, Savremena administracija, Bel -

grade, 1996.7. Maličević Ž., Zgradić I.: Correlative neuroanatomy of skeletal muscles, textbook, Kragujevac University, 1999.8. Stanić V., Maličević Ž. and al.: Chest surgery (editor: Jaković R. M.), textbook, Medical faculty, Belgrade, 2004.9. Harper H. A., Roodwell V.W., Mayes P. A.: Review of physiological chemistry, 16 th US ed., Savremena adminis-

tracija, Belgrade, 1982.10. Mihajlović Šćepović M, Veljković S, Ranković G, Radenković M, Cekić S, Veličković D, Nešić M, Veličković I,

Branković S, Stojiljković N, Ćirić M, Pavlović V.: Physiology practicum for pharmacy students, Medical faculty, Niš, 2005.

Number of active teaching: Other classes:Lectures: 45 Exercises: 15 Other forms of teaching: Students research work:

Methods of teaching:Lectures and Practical classes lectures, practical classes, computer animation and simulation of physiological processes



MICROBIOLOGY

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: MicrobiologyTeacher: Subjects status: compulsorySemester: second year, fourth semesterECTS: 7Requirement: noSubjects objective: Introduction to the cellular organization and the characteristics of prokaryotic and eukaryotic microorganisms and viruses. Acquisition of basic knowledge to work in the microbiology laboratory, learning about microbial pathogens, symptoms and treatment of microbial diseases, epidemiology and prevention methods, mechanisms of resistance to antibiotics acquirement and measures to prevent the occurrence of multiresistant strains.Subjects outcome: After completing this course, students will have the knowledge necessary for aseptic work in microbiology laboratories, pharmaceutical industry and practices, identification of etiologic agents of infectious diseases, the interpretation of in vitro

testing of microorganisms susceptibility to antibiotics and chemotherapeutics, application of principles of the rational antibiotic therapy, chemoprophylaxis and active immunization, good manufacturing practices, methods for microbiological testing and application of microorganisms in the industry.Subjects content:Lectures:General Bacteriology: classification of organisms, anatomy and physiology of the bacterial cell, bacterial metabolism, the effect of physical and chemical agents on microorganisms, pathogenic and virulence factors, antibiotics, antifungal drugs and chemotherapeutics, normal flora, rapid diagnostic tests and molecular methods in microbial diagnostics. Special Bacteriology: Gram positive and Gram negative cocci relevant for human pathology, gram positive and gram positive sporogenic bacills, gram-negative enterobacteria, spiral bacterium, chlamydia and mycoplasma. Microbiological control of pharmaceutic preparations: the principles of good manufacturing practice and methods to prevent microbial contamination, the basic principles of recombinant DNA technology, medically important polypeptides and proteins obtained by the DNA technology, the use of microorganisms in the pharmaceutical industry, the use of microorganisms and their products in a variety of assays and models to investigate the metabolism of drugs. General and special virology: general properties of viruses, replication, effects of physical and chemical agents on viruses, pathogenesis and control of viral infection, interferons and antiviral drugs, laboratory diagnosis, DNA and RNA viruses relevant to human pathology. Medical parasitology: mycology, yeast morphology and laboratory diagnosis of mycosis, dermatophytes and systemic mycoses.Practical classes Methods of microscopy and staining, sterilization and disinfection, isolation and identification of bacteria, antibiogram, gram positive cocci, gram-negative cocci, gram positive sporogenic and asporogenic bacilli, enterobacteria, mycoplasma and chlamydia, microbiological testing of drugs, laboratory diagnosis of viral, parasitic and fungal infections. Case study analysis (selecting relevant methods). Part of the exercises is performed in the microbiology laboratory.Literature: 1. Švabić Vlahović M. i sar.: Medicinska bakteriologija, Savremena administracija, Beograd, 2005. 2. Jovanović Tanja, Marković Ljubiša (ur.): Virusologija, udžbenik, Libri Medicorum, Medicinski fakultet, Beograd, 2008.3. Kranjčić-Zec I. i sar.: Medicinska protozoologija, udžbenik, Libri Medicorum, Medicinski fakultet, Beograd, Beograd, 2006.4. Gajin Slavka, Gantar Miroslav, Petrović Olga, Matavulj Milan: Praktikum iz mikrobiologije za studente biologije, Univerzitet

u Novom Sadu, 1982.5. Kranjčić-Zec I.: Medicinska parazitologija, priručnik za praktičnu nastavu, Savremena administracija, Beograd, 2000.6. Suvajdžić Ljiljana: Priručnik iz mikrobiologije sa vežbama za studente farmacije, Ortomedics, Novi Sad, 2004.7. Tortora Gerard J., Funke Berdell R., Case Christine L.: Microbiology: An Introduction, Books a la Carte Edition, 10 th ed.,

Benjamin Cummings, New York, 2009.8. Denyer Stephen P., Hodges Norman, Gorman Sean P. (eds.): Hugo and Russell's Pharmaceutical Microbiology, Willey, New

York, 2004.9. Arsenijević Arsić V.: Medicinska helmintologija, Elvod-Print, Lazarevac, 2003.10.Javetz Е., Melnik Ј., Adelberg Е.: Medicinska mikrobiologija, Savremena administracija, Beograd, 2000.Number of active teaching: Other classes:Lectures: 45 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: lectures, exercises, work in microbiology labs.



PHARMACOGNOSY I

Study programes: pharmacy Type and level of study: integrated academic studiesName of subject: Pharmacognosy ITeacher: Subjects status: compulsorySemester: second year, fourth semester

ECTS: 4Requirement: Botany , Organic Chemistry I Subjects objective:Throughout the classes, students provide information sufficient to: know partition path biosynthesis, distribution, localization, physical-chemical characteristics, role in the plant and use in pharmaceutical primary and secondary pharmacologically active natural molecules; known secondary structures of natural products; government methods for qualitative and quantitative analysis, extraction, isolation and purification of pharmacologically active natural molecules, to use and evaluate literature and specific quality control methods described in Pharmacognosy in the current pharmacopoeia.Subjects outcome: After passing the exam, student is able to: know the biosynthetic origins and chemical structure of pharmacologically active natural ingredients; know the distribution of the active ingredients in plants and animals; perform qualitative and quantitative analysis of natural active ingredients; conceived and carried out the extraction and separation of compounds of natural origin; known natural raw materials used for the isolation of compounds for the pharmaceutical industry.Subjects content:Lectures:Products of primary metabolism of plants (pharmacological activity and application) and general metabolic pathways. Plant secondary metabolites: biological function, classification. Connection between primary and secondary metabolism of plants. Definition, the presence of nature, distribution, localization, biological function, physical-chemical properties, structure, evidence, determination, extraction, purification, pharmacological activity, the use of pharmaceuticals: plant phenolic compounds (simple phenols, coumarins, lignans, lignins, flavonoids, tannins, quinones), isoprenoids (terpenes and steroids), monoterpene heteroside and essential oils, saponosides, cardiac heteroside, nitrogen compounds, sulfur heteroside of alkaloids.Practical classes:Basic principles of laboratory tests for Pharmacognostic. Qualitative analysis heteroside. Determination antrahinonskih heteroside. Determination of flavonoid heteroside. Detection of saponins, tannins and other phenolics. Determination of polyphenols. Determination of essential oils and other Officinal drug testing. Qualitative analysis of alkaloids. Quantitative analysis of alkaloids. Excursion.Literature: 1. Kovacevic, N.: Principles of Pharmacognosy, Serbian schoolbook, Belgrade 2002.2. Gorunović M, Lukic P. Pharmacognosy, Belgrade, 2001.3. Haensel R., Sticher O.: Pharmakognosie-Phytopharmazie, Springer, Berlin, 2007.4. Evans C. W.: Trease and Evans' Pharmacognosy, WB Saunders, Edinburgh, 2002.5. Jugoslavica Pharmacopoeia 2000, Vol. 2 PH. South. V, Modern Administration, Belgrade, 2001. Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:lectures, interactive lectures, Practical classes.



Pharmaceutical Organic Chemistry I

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Pharmaceutical Organic Chemistry ITeacher: Subjects status: compulsorySemester: second year, fourth semesterECTS: 4Requirement: Organic Chemistry IISubjects objective:

The student should acquire knowledge of the basic principles of physico-chemical characterization of drug substances; applying knowledge of physical and chemical parameters in the analysis of relations and structures (structure-activity relationship), properties, effects and selectivity of pharmacologically active substances, understand the basic principles of the mechanism of action of drugs on molecular level; acquire basic knowledge of the principles of computer design drugs; acquire knowledge about certain organic pharmacologically active compounds.Subjects outcome: Students are expected to analyze the relations between the structure, properties, effects and selectivity of pharmacologically active organic substances in order to design new and optimization of existing organic pharmacologically active substances, apply knowledge of organic compounds of therapeutic importance for human.Subjects content:Lectures Radiopharmaceuticals in diagnosis and treatment: X-ray contrast media and other diagnostic tools, diagnostic tools in NMR and other diagnostic procedures. Hemotherapeutics. folate reductase inhibitors, sulfonamide, disinfectants, antiseptics, antifungals, antiprotozoals, antihelminthics, synthetic antifungals, uroantiseptics, antituberculosis drugs. Antineoplastic agents, antivirals. Hormones, steroid hormones, antiestrogens, aromatase inhibitors, anabolics, antiandrogens, antigestagens, oral contraceptives, corticosteroids, antiinflammatory steroids, thyroxine, thyrostatic, oral antidiabetic drugs. Vitamins, enzymes and coenzymes in therapy. Pro-vitamins, antivitamins. Fat soluble vitamins A, D, E and K groups. Soluble vitamins: B1, B2, B3, B5, B6, folic acid, B12, B15, H, U, C, Q.Practical classesPreparative getting four pharmacologically active substance of the problem: synthesis, isolation, purification, identification. Qualitative analysis of drug substances. Identification of medicinal substances, elemental analysis, reactions of functional groups, reactions of cations and anions. pH and specific optical rotation in identification. Crystallization, melting point determination. Proving the structure of synthesized compounds. The application of spectroscopic methods for the identification (IR, NMR, mass spectrometry). Microanalysis newly synthesized substances.Literature:1. Radulović D., Vladimirov S.: Farmaceutska hemija I deo, udžbenik, Farmaceutski fakultet, Beograd 2005.2. Vladimirov S., Živanov-Stakić D.: Farmaceutska hemija II deo, udžbenik, Farmaceutski fakultet, Beograd, 2006.3. Williams D. A., Lemke T. L.: Foye`s Principles of Medicinal Chemistry, 5th еd., Lippincott Williams & Wilkins, Baltimore,

2002. 4. Foye William, Lemke Thomas, Williams David: Principles of Medicinal Chemistry, 5th ed., Willams & Wilkins, Baltimore,

2002.5. Wilson E. Gisvold J. B.: Textbook of Organic Medicinal and Pharmaceutical Chemistry, Lippincott Company London,

Philadelphia, 2004.6. Vujić Z., Brborić J., Čudina O., Erić S., Ivković B., Vučićević K., Marković B.: Priručnik za praktičnu nastavu iz

farmaceutske hemije I i II, Beograd, 2004.7. European Pharmacopoeia, European Directorate for the Ouality of Medicine and Health Care, 5th ed., Council of Europe,

Strasbourg, 2005.Number of active teaching: Other classes:Lectures: 30 Exercises: 45 Other forms of teaching: Students research work:Methods of teaching:lectures, interactive lectures, laboratory exercises.

http://www.google.com/images?q=folate+reductase&hl=en&safe=images&spell=1&sa=X&oi=image_result_group&ei=8i--Ue-ANKmu0AGFyIGwDw&ved=0CCkQsAQ



Bromatology

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studies Name of subject: BromatologyTeacher: Subjects status: compulsorySemester: second year, fourth semesterECTS: 4Requirement: General BiochemistrySubjects objective:The aim of the subject: Familiarization with food composition, macro and micronutrient content, energy value and food potential to fulfill nutritive and human energy requirements; possibility of food combining and food replacement in order to gain specific nutritive effect; giving the information regarding chemical and nutritive changes during the thermal treatment; information about nutrient–drug interactions.Subjects outcome: After finishing the course student will be able to give information concerning appropriate choice of food staffs and their combination for different population groups; to provide the information to patients concerning basic food–drug interactions.Subjects content:LecturesFood and nutrient definition. Factors influencing food selection/choice. Food energy value. Basic food components, energy value, chemical properties, basic role in organism, biological value. Protective nutrients. Non-nutritive biologically active food components. Types of food according to their role in organism. Water as a food. Dietary food. Food additives and contaminants. Influence of thermal treatment and processing on food biological value. Interactions of nutrients in food, in digestive tract and in organism. Food–drug interactions.Practical classesAnalytical methods in food and nutrients. Quality and safety assessment of food and dietary products (basic food composition, agreement of dietary products composition with specific nutritional requirements, food spoilage, additives, contaminants, food labeling, packaging, drinking water). Communication with patients practicing – providing information regarding food –drug interactions.Literature: 1 Belitz H. D., Grosch W.: Food Chemistry, 3rd ed., Springer, Berlin, 2004.2. Mirić M., Stanimirović D.: Praktikum iz bromatologije, 3. izd., Grafopan, Beograd, 2001.3. Hui Y. H. (ed.): Handbook

of Food Science, Technology and Engeneering, Vol.1, Taylor & Francis, Philadelphia, 2006.4. Elke Arendt K., Dal Bello Fabio (eds.): Gluten-free cereal products and beverages, Elsevier, Waltham, Massachusetts,

2008.5. Greenfield H., Southgate D.A.T.: Food Comppositions, Food and Agriculture, Organization of the United Nations, 2 nd

ed., Rome, 2003.6. Coultate T. P.: Food - The chemistry of it’s Components, Royal Society of Chemistry, Herts, 1995.Number of active teaching: Other classes: Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:Lectures, laboratory exercises, case study


Lectures 5 Exame 60Practical classes 15

Colloquiums 20Seminars 0

STATISTICS IN PHARMACY

Study programes: pharmacyType and level of study: integrated academic studies Name of subject: Statistics in PharmacyTeacher:Subjects status: compulsorySemester: second year, fourth semesterECTS: 2Requirement: noSubjects objective:The objective of the course is for students to learn statistical terminology, understand simple statistical methods and result interpretation, the application of statistical tests on examples from pharmacy, and to learn to use the statistical package.Subjects outcome: After passing the exam, the student will be able to: properly select the sample and collect the data, select the appropriate statistical method used to analyze the data, interpret the results, easly use MS Excel and the statistical package.Subjects content:LecturesStatistical terminology. Population and sample. Variable sizes and data. Editing data. Graphical representation and tabulation. Measures of central tendency. Deviation measures. Normal distribution. The standard normal distribution. Calculation of area under the normal distribution. Testing the hypothesis. Type I and type II errors. P-value. One-sided and two-sided student's test. Variance ratio test. The analysis of variance. The analysis of variance for one classification criterion. Linear regression analysis. The regression equation. Correlation analysis. The coefficient of determination. The coefficient of correlation. Using regression analysis to predict. Non-parametric methods. Parametric t-test (Mann-Whitney U-test). Non-parametric correlation. Chi-square test. Assessment of agreement. Test of independence. Homogeneity test. The confidence interval of expected values.Practical classesThe application of statistical methods in examples from pharmaceutical practice using the statistical package.Literature:1. Lozanov-Crvenković Zagorka: Statistika u farmaciji i statističke formule i tabele, udžbenik, 2. izd., Medicinski fakultet, Novi

Sad, 2009.2. Grujić Vera, Jakovljević Đorđe: Primena statistike u medicinskim istraživanjima, udžbenik, Medicinski fakultet, Novi Sad,

2002.3. Sheskin D. J.: Handbook of Parametric and Nonparametric Statistical Procedures Chapman & Hall/CRC, Washington, D.C.,

2000. 4. De Muth J. E.: Basic Statistics and Pharmaceutical Statistical Applications, Chapman & Hall, Washington, DC, 2006.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, work with the statistical software package, addressing examples from pharmacy practice, e-learning



PHARMACOGNOSY II

Study programes: pharmacy Type and level of study: integrated academic studiesName of subject: Pharmacognosy IITeacher: Subjects status: compulsorySemester: third year, fifth semesterECTS: 4Requirement: Pharmacognosy ISubjects objective:The subject provides knowledge about the most important natural medicinal raw materials (drugs) which are important for medicine and pharmacy: definition and characteristics, identification methods, ingredients, quality, production, operation and implementation. Subjects outcome: After passed exam, student is able to: define the drug and its biological source, familiar with the morphological and anatomical characteristics of the drug, known chemical ingredients of drugs, perform the identification of drugs, perform quality testing of drugs, knowing the possibility of using drugs, involved in the design, organization and management of the production process drugs and quality assurance.Subjects content:Lectures: The introductory part. Definition, classification, application of drugs. Production of drugs. The quality of drugs. Pharmacopoeia monographs of drugs. Drugs with alkaloids (pirolidinskim, piperidine, pyridine, fenilalkilaminskim, isoquinoline, tropolonskim, indolnim, imidazole, purine, terpene and steroid). Drugs with allantoin. Drugs with cyanogen Heterozoids. Drugs with glucosinolates Alin. Drugs with lectins. Drugs with phenolic Heterozoids. Drugs with lignanskim Heterozoids. Drugs with coumarin Heterozoids. Drugs with flavonoid and antocijanskim Heterozoids. Tannic drugs. Saponinske drugs. Drugs with derivatives floroglucinola and orcinola. Drugs with cardiotonic Heterozoids. Drugs with phytosterols. Drugs with sekoiridoidnim and iridoidnim Heterozoids. Drugs with free triterpenes. Drugs with naftohinonskim, antrahinonskim Heterozoids and naftodiantronima. Aromatic drugs and essential oils. Oleoresins, resins, balsams. Lipids (fatty oils, waxes, lecithins). Drugs with carbohydrates: heteropolisaharidne drugs (tires, phlegm and mucus drugs) and pectins. Vitamin drugs. BandagesPractical classes: Macroscopic, microscopic and chemical identification of drugs. Quality testing oficinalnih drugs.Literature: 1. Kovacevic, N.: Principles of Pharmacognosy, Serbian schoolbook, Belgrade 2002.2. Gorunović M, Lukic P. Pharmacognosy, Belgrade, 2001.3. Haensel, R., Sticher O.: Pharmakognosie-Phytopharmazie, Springer, Berlin, 2007.4. Evans C. W.: Trease and Evans' Pharmacognosy, WB Saunders, Edinburgh, 2002.5. Jugoslavica Pharmacopoeia 2000, Vol. 2 PH. South. V, Modern Administration, Belgrade, 2001.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:lectures, Practical classes.


Lectures 5 Exame 50Practical classes 25

Colloquiums 20Seminars 0

Pharmaceutical Organic Chemistry IIStudy programes: pharmacyType and level of study: integrated academic studiesName of subject: Pharmaceutical Organic Chemistry IITeacher: Subjects status: compulsorySemester: third year, fifth semesterECTS: 7Requirement: Instrumental Pharmaceutical AnalysisSubjects objective:Students should apply knowledge of physico-chemical parameters in the analysis of relations / structures, properties, effects and selectivity of pharmaceutical active compounds and to understand the mechanisms of action of organic pharmaceutical active compounds that act on the nervous and cardiovascular system.Subjects outcome: Students are expected to analyze the relations between the structure, properties, effects and selectivity of the organic pharmaceutical active substances in the field of pharmaceutical active compounds that act on the nervous and cardiovascular system.Subjects content:Lectures Drugs that act on the nervous system: antipsychotics, anxiolytics, antidepressants, antiemetics, antimigraine drugs, gastoprokinetics, blockers of H1 and H2 histamine receptors, hypnotics, antiepileptics, analeptics, nootropics, anorexics, local anesthetics, opioid analgesics, antidiarrheals, antitusics, mediators of inflammation, analgoantipyretics, antirheumatics, non-selective and selective COX inhibitors, cholinergics and anticholinergics, muscarinic, acetylcholine and nicotinic receptor agonists, indirect inhibitors of acetylcholinesterase, irreversible central selective acetylcholinesterase inhibitors, muscarinic receptor antagonists, antiparkinsonics, spasmolitics, nicotinic receptor antagonists. Drugs acting on the cardiovascular system: adrenergics, alpha and beta receptor agonists and blockers,antiarrhythmics, vasodilators, cardiotonic glycosides, diuretics, antihypertensives, antihyperlipidemics, inhibitors of HMG-CoA reductase, anticoagulants, thrombolytics.Practical classesExamination of related substances and degradation products by thin layer chromatography; qualitative analysis of mixtures of drug substances: sulfamethoxazole, sulfanilamide, trimethoprim, aminophenazone, phenazone, propyphenazone, acetaminophen, caffeine. The degree of purity of drug substances. Detection of cations: NH4

+, As3+, Ba2+, Fe3+, Ca2+; anions: NO3-, SO42-, Cl-, heavy

metal impurities in the sample examined. Examination of acidity and alkalinity, clarity, color. pharmaceutical purity.Literature:1. Radulović D., Vladimirov S.: Farmaceutska hemija I deo, udžbenik, Farmaceutski fakultet, Beograd 2005.2. Vladimirov S., Živanov-Stakić D.: Farmaceutska hemija II deo, udžbenik, Farmaceutski fakultet, Beograd, 2006.3. Williams D. A., Lemke T. L.: Foye`s Principles of Medicinal Chemistry, 5 th еd., Lippincott Williams & Wilkins, Baltimore,

2002. 4. Foye William, Lemke Thomas, Williams David: Principles of Medicinal Chemistry, 5th ed., Willams & Wilkins, Baltimore,

2002.5. Wilson E. Gisvold J. B.: Textbook of Organic Medicinal and Pharmaceutical Chemistry, Lippincott Company London,

Philadelphia, 2004.6. Vujić Z., Brborić J., Čudina O., Erić S., Ivković B., Vučićević K., Marković B.: Priručnik za praktičnu nastavu iz farmaceutske

hemije I i II, Beograd, 2004.7. European Pharmacopoeia, European Directorate for the Ouality of Medicine and Health Care, 5th ed., Council of Europe,

Strasbourg, 2005.Number of active teaching: Other classes:Lectures: 30 Exercises: 45 Other forms of teaching: Students research work:Methods of teaching:lectures, interactive lectures, calculation exercises.


Lectures 5 Exame 50Practical classes 20Colloquiums 25

Seminars 0NEUROSCIENCE

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: NeuroscienceTeacher:Subjects status: compulsorySemester: third year, fifth semesterECTS: 4Requirement: Physiology IISubjects objective:Acquiring knowledge from basic neuroscience, molecular neuropharmacology and clinical neuropharmacology in order to understand drug effects on nervous system functions, drug dosing that are used for therapy of nervous system diseases and critical evaluation of wanted and adverse effects of drugs used in therapy of nervous system diseases.Subjects outcome:Students, apart from acquiring the basics of neuroscience, will also gain knowledge that will enable them to understand: mechanisms of action of wanted and adverse effects of drugs, used in therapy of nervous system diseases and critical evaluation of clinical tests and non-scientific publications that describe latest research in the field of neuropharmacology.Subjects content:LecturesBasic principles of neuroscience and basic neuroanatomy. Nervous system cells. Blood-brain barrier. Primary characteristics of neurons: electric nature, action potential and synaptic transmission. Basic categories of neurotransmitters: glutamic acid, GABA, glycine, dopamine, norepinephrine, serotonin, acetyl-choline; neuropeptides and other modulators. Pharmacological manipulation of the transmitters, neuropeptides and other modulators of synaptic transmission. Medicines and nervous system diseases: pain (acute and chronic), epilepsy, anxiety, schizophrenia, addiction diseases. Computer neuropharmacology and detection and discovery of new drugs.Practical classesComputer simulation of basic neuron characteristics and neurotransmission. Critical evaluation of scientific papers and clinical tests: neuropharmacological cases: problem based learning by using method of team-based learning.Literature: 1. Kandel Eric R., Schwartz James H., Jessell Thomas M.: Principles of Neural Science, McGraw-Hill Medical, 2000.2. Nestler Eric, Hyman Steven, Malenka Robert: Molecular Basis of Neuropharmacology: A Foundation for Clinical Neuro-

science, McGraw-Hill Professional, 2008.3. Cooper Jack R., Bloom Floyd E., Roth Robert H.: The Biochemical Basis of Neuropharmacology, Oxford University Press,

New York, 1996.4. Rušić Stojiljković: Basic Principles of Molecular Neurobiology, textbook, Faculty of Biology, Belgrade, 1998.5. Stevanović: Physiology of Nervous System, textbook, Faculty of Veterinary Medicine, Belgrade, 2004.Number of active teaching: Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, laboratory exercises, work in groups.



PATOPHYSIOLOGY

Study programes: pharmacy – medical biochemistry

Type and level of study: integrated academic studiesName of subject: PatophysiologyTeacher: Subjects status: compulsorySemester: third year, fifth semesterECTS: 5Requirement: Physiology I, Physiology IISubjects objective: The subject should provide students with knowledge about the mechanisms of cell damage tissues and organs, and introduce them to the morphological changes that underlie diseases; enable them to recognize morphological changes in cells, tissues and organs; enable them to meet the etiology, pathogenesis and clinical manifestations of major metabolic disorders and functional disorders of organs and organ systems, the causes and mechanisms of neoplastic cell transformation and growth characteristics of the tumor and the changes it causes in the body. Subjects outcome: After completing the course the student is familiar with basic medical terminology and is able to adequately present the relevant medical facts, understand the etiology and pathogenesis of primary metabolic and functional disorders of organs and organ systems of man, is able to link their clinical manifestations of the causes and mechanisms of their formation and has the pathobiological base for understanding the mechanisms of action of chemical agents and drugs, as well as diagnostic strategy in the case of pathologies. Subjects content:LecturesAdaptation, aging, cell death. Morphological changes of the cells. Etiopathogenesis of acute and chronic inflammation. Malignant cell transformation and growth. Disturbance of water and electrolytes. Disturbances of acid-base balance. Etiopathogenesis: malnutrition, obesity, diabetes mellitus, atherosclerosis, cardiovascular dysfunction, respiratory dysfunction, renal dysfunction, dysfunction of the nervous system, dysfunction of the endocrine glands and the neuroendocrine regulation of digestive disorders, disorders of the composition and function of blood, dysfunction skin.Practical classes Cell injury and cell death. Ethiopathogenesis of inflammation. Malignant cell transformation and growth. Functional disorder of water, sodium and potassium. Metabolism of calcium, magnesium and phosphate. Etiopathogenesis of diabetes mellitus, atherosclerosis, acid-base balance. Functional disorders of cardiovascular system, respiratory system, kidney function, nerve function, the function of the endocrine glands and neuroendocrine regulation and function of the digestive tract, liver, composition and functions of blood.Literature: 1. Gamulin S., Marušić M., Kovač Z.: Patophysiology, Medical publishing, Zagreb, 2005.2. Maličević Živorad and al.: Bases of pathological physiology, textbook, Paneuropian University "Apeiron", Banja

Luka, 2009.3. Babić Lj., Borota R., Lučić A.: Handbook of practical and seminar classes of pathological physiology, 9 th ed.,

Medical faculty, Novi Sad, 2007.4. Kovač Z., Gamulin S. and al.: Patophysiology, Assignments for problematic seminars, Medical publishing, Za-

greb, 2006.5. Živančević-Simonović S.: General pathological physiology, textbook, Medical faculty Kragujevac, 2002.6. Đorđević-Denić G. and al.: Special pathol. physiology, textbook, Zavod za izdavanje udžbenika, Belgrade, 2003. 7. Leposavić G.: Pathological physiology for pharmacy students, practicum, Faculty of pharmacy, Belgrade, 1996Number of active teaching: Other classes:Lectures: 45 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:lectures, solving of pathophysiological problems, case studies.



PHARMACOLOGY

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: PharmacologyTeacher: Subjects status: compulsorySemester: third year, fifth semesterECTS: 4Requirement: Physiology I, Physiology IISubjects objective: To provide: knowledge about mechanism of action of drugs, necessary information for understanding different drug effects, understanding therapeutic and adverse effects of different groups of drugs, knowledge about principles of therapeutic use of drugs. Subjects outcome:After completion the exam, a student is expected to be able to: identify mechanisms of different effects of drug groups, connect therapeutic and adverse effects of different drug groups with their different pharmacological effects, build own critical attitude towards drugs. Subjects content:Lectures Introduction. History of pharmacology. Division of pharmacology. Definition of drug. General principles and development of a new drug. Ways of application of drugs. Dosage. LAMDER (liberation, apsorption, distribution, metabolism and elimination of drugs and body response to drugs). Effects of drugs on the body. Types and characteristics of drug effects. Mechanisms of action of drugs. Factors that influence drug effects. Changes in drug effects after repeated dose. Interaction of drugs. Adverse effects of drugs. Drug abuse. Basics of clinical pharmacology. Non-steroidal anti-inflammatory drugs. Antirheumatic drugs that modify course of rheumathoid disease. Pharmacology of the blood: anticoagulant and coagulant drugs, antiaggregation drugs, local and systemic haemostatics. Antianemics. Water and electrolytes: means for fluid compensation. Drugs for parenteral nutrition. Pharmacology of respiratory tract. Pharmacology of cardiovascular tract. Drugs and therapy of peripheral vascular diseases. Antilipemics. Pharmacology of alimentary tract. Immunosuppressants and immunostimulators. Pharmacology of vitamins. Drugs for therapy of obesity. Pharmacology of hormones. Pharmacology of antimicrobial drugs. Antifungal drugs. Antiviral drugs. Amebicidni lekovi. Antimalarial drugs. Antiparasitic drugs. Antiseptics and disinfectants. Chemotherapy of malignant diseases.Practical classes General principles and development of a new drug. Operating with pharmacological database on Internet. Definition of drug. Groups of drugs. Prescription of drugs. RecipeLiterature: 1. Rang H. P., Dale M. M., Ritter J. M., Moore P. K.: Pharmacology, 5th ed., Data Status, Belgrade, 2004.2. Đaković Švajcer K.: Basics of Pharmacology, Ortomedics, Novi Sad, 2010.3. Varagić V., Milošević M.: Pharmacology, 20th ed.., Elit Medica, Belgrade, 2005.4. Jakovljević V., Sabo A., Tomić Z. (editors), Stević S. et al.: Drugs on the Market 2009, Manual on drugs and their use, ATC

classification, 2nd ed., Novi Sad, Belgrade, Niš, Kosovska Mitrovica, Podgorica, Ortomedics, Novi Sad, 2007, 2009.5. Bukarica-Gojković Ljiljana et al.: Practicum for Pharmacology, Faculty of Pharmacy, Belgrade, 2009.Number of active teaching: Other classes:

Lectures: 45 Exercises: 60 Other forms of teaching: Students research work:Methods of teaching:lectures, laboratory exercises in vitro, computer simulations.



NEUROPHARMACOLOGY

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: NeuropharmacologyTeacher: Subjects status: compulsorySemester: third year, sixth semesterECTS: 5Requirement: Physiology I, Physiology IISubjects objective: To get students to know basic terms about medicines, their characteristics, mechanism of action, therapeutic and adverse effects, interactions and principles of pharmacotherapySubjects outcome:After passing the exam students will have knowledge and be able to identify different mechanisms of action of various groups of drugs, to connect therapeutic and adverse effects of different groups of drugs with their pharmacological effect, and to have critical attitude towards drugs and therapeutic procedures.Subjects content:Lectures Introduction: general pharmacology of neurotransmitters, receptors and transmitters. Opiates, opioids. Hypnotics, anxiolytics. Hallucinogens. Antipsychotics. Antidepressants. Psychostimulants. Addiction. Neurodegenerative brain diseases. Central and peripheral pain. Inflammatory brain diseases. Vascular brain diseases, stroke. Pharmacology of autonomic nervous system. Pharmacology of cholinergic nervous system. Pharmacology of adrenergic nervous system. Pharmacology of central nervous system.Practical classesRelationship between dose and effects of drugs. Drug interactionsLiterature: 1. Rang H. P., Dale M. M., Ritter J. M., Moore P. K.: Pharmacology, 5th ed., Data Status, Belgrade, 2004.2. Varagić V, Milošević M: Pharmacology, 20th ed.., Elit Medica, Belgrade, 2005.3. Katzung B. G., Basic&Clinical Pharmacology, Lange Medical Books, The McGraw-Hill Companies Inc, 9 th ed.,

Singapore, 2003.4. Goodman L. S., Gilman A.: The Pharmacological Basis of Therapeutics, 10th ed., McGraw-Hill, New York, 2001.5. Martindale Complete Drug Reference, 34th ed., Pharmaceutical Press, London, 2004.6. Jakovljević V., Sabo A., Tomić Z. (editors), Stević S. et al.: Drugs on the Market 2009, Manual on drugs and their use,

ATC classification, 2nd ed., Novi Sad, Belgrade, Niš, Kosovska Mitrovica, Podgorica, Ortomedics, Novi Sad, 2007, 2009.7. Bukarica-Gojković Ljiljana et al.: Practicum for Pharmacology, Faculty of Pharmacy, Belgrade, 2009.8. Radulovic J., Spiess J. i sar.: International Encyclopedia of the Social & Behavioral Sciences (eds.: Smelser N. J., Baltes

P. B.), Elsevier Science Ltd., Oxford, 2002.9. Radulovic J., Blank T., Eckart K., Radulovic M., Stiedl O., Spiess J. et al.: Regulatory Peptides and Cognate receptors

(ed.: Richter D.), Results and Problems in Cell Differentiation, Springer, Heidelberg, 1999.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: lectures, laboratory exercises in vitro, computer simulations.



Dietetics

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studies Name of subject: Dietetics

Teacher: Subjects status: compulsorySemester: third year, sixth semesterECTS: 3Requirement: BromatologySubjects objective:The aim of the subject is to provide information to students regarding actual nutritional guides, recommendations and other methods for creating dietary regimes, specific nutritional requirements of different age categories as well as in therapy and in disease prevention.Subjects outcome: After finishing the course student will be able to give information concerning dietary recommendations interpretation, to provide basic instructions regarding healthy diet of common population, to give inputs to patients suffering from non-contagious chronic diseases where the nutrition is co-therapy; to recognize nutritional disorders and to refer patients to appropriate health services.Subjects content:LecturesRole of food. Principles of rational nutrition and methods for conducting rationale nutrition. Food pyramid, guide for appropriate food combination and recommendation of daily intake of certain food. Balance studies, requirements for certain nutrients intake for specific population groups. Recommended daily intake – RDI and DRI values. Energy requirements of people. Creating of optimally balanced diets. Dietary regimes for health promotion with special aspects to vulnerable population groups. Basics of nutritional epidemiology and dietary regimes in order to decrease risks of certain disease. Allergies and food components intolerances. Nutritional disorders (anorexia, bulimia). Food fortification, functional food, dietary food, dietary supplements. The role of pharmacist in providing information regarding the basics of proper nutrition.Practical classes Nutritional status determination. Practical calculation of energy requirements. Calculation of content of fats, carbohydrates and proteins in overall daily energy consumption. Calculation of food energy value. Examples of usage of food components tables. Evaluation of mineral content, vitamins in dietary supplements and comparison to RDA values. Creation of three days nutrition diary and analysis of energy values and frequencies of certain nutriments. Practice communication with patients in simulated chosen situation which require providing information about nutrition. Practice communication with patients in simulated chosen situation which require support of specific nutrition regime. Analysis of literature, popular literature or internet.Literature: 1. Živković Roko: Dijetetika, Medicinska naklada, Zagreb, 2002.2. Ziegler E. E., Filer L. J.: Present Knowledge of Nutrition, ILSI Press, Washington, D.C., 1996.3. Dietary reference intake for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and aminoacids

(macronutrients), Food and Nutrition Board, Institute of Medicine, Nat. Academic Press, Washington, D.C., 2002.4. Sadler M. J., Strain J. J., Cabalero B.: Encyclopedia of human nutrition (e-verzija), Academic Press, London, 2009.5. Elke K. Arendt, Fabio Dal Bello (eds.): Gluten-free cereal products and beverages, Elsevier, Waltham, Massachusetts, 2008.6. Greenfield H., Southgate D.A.T.: Food Compositions, Food and Agriculture, 2nd ed., Organization od United Nations, Rome,

2003.7. Coultate T. P.: Food - The chemistry of it’s Components, Royal Society of Chemistry, Herts Press, London, 1995.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, case study, analysis of professional and / or popular articles



Medical Biochemistry

Study programes: pharmacyType and level of study: integrated academic studies Name of subject: Medical BiochemistryTeacher: PhDSubjects status: compulsorySemester: third year, sixth semesterECTS: 8Requirement: General BiochemistrySubjects objective:Studying and measuring biochemical changes in the state of disease, learning about biochemical concentrations of constituents in the body fluids, metabolism disorders of carbohydrates, proteins, lipids, water, and electrolytes, laboratory testing of organ function, endocrine function and biochemical changes during the disease, the selection of appropriate tests for the diagnosis and interpretation of results.Subjects outcome: After passing the exam, students will understand the role of biochemical laboratory in the diagnosis, monitoring and treatment of disease, will distinguish between different types of biological material used in biochemical laboratories, will know the ways of using it, storing and influences of various factors, know the theoretical principles of methods used in biochemical laboratories, as well as factors that influence the choice, will know how to handle the instruments, to understand the clinical significance of determining biochemical parameters, will know how to interpret data of laboratory tests, known to use specialized literature, know how to recognize and solve the problem.Subjects content:LecturesRegulation of carbohydrate metabolism, disorders. Laboratory diagnosis and monitoring of diabetes. Features and functions of the major plasma proteins and changes in concentration. Disorders in protein metabolism. The metabolism of lipids, lipoproteins, apolipoproteins, disorders. Laboratory testing of hyperlipidemia. Biochemical markers and risk factors for atherosclerosis. Regulation of osmolality and volume of body fluids. Disorders in the metabolism of water: dehydration and hyperhydration. Regulation of the electrolyte in the body fluids and electrolyte disorders in metabolism. Acid-base balance and disorders in acid-base balance. Metabolic regulation of Ca, P and Mg metabolism disorders. Iron metabolism, iron serum binding capacity, metabolism disorders. Hemoglobin, hemoglobinopathies, thalassemia. Tests of glomerular and tubular function. Physico-chemical analysis of urine and urine sediment. Creatinine, urea, uric acid levels. Liver function. The metabolism of bilirubin and hyperbilirubinemia. Bile acid and metabolism disorders. The biochemical aspects of liver disease. Investigation of gastrointestinal function. Diagnostic monitoring of enzyme activity. Laboratory findings in disorders of the hypothalamus, pituitary, thyroid, adrenal glands and gonads. Tumor markers.Practical classesTypes and routes of biological material. Biochemical laboratory diagnostic methods: using automatic pipettes; preparation of solutions; execution method of indentifying protein and sugar solutions (fluids) and knowledge of the use of colorimeter measurement of the concentration of the analyte in the test sample (using a standard curve of standard solution or molar absorption coefficient); use centrifuges; biochemical methods for the quantitative determination of glucose, triacylglycerols, cholesterol, creatinine, urea, bilirubin, uric acid, electrolyte concentrations, measurement of enzyme activity in body fluids. Calculating concentration of biochemical parameters. Quantitative determination of serum: glucose, total protein, cholesterol, bilirubin, urea, creatinine. Determination of blood: hemoglobin. Enzymes: determination of acid and alkaline phosphatase, aspartate-aminotransferase and alanine-aminotransferase. Chemical examination of urine. Examination of the urine sediment.Literature: 1. Spasić S., Jelić-Ivanović Z., Spasojević-Kalimanovska V.: Medicinska biohemija, udžbenik, Farmaceutski fakultet,

Beograd, 2004.

2. Spasić S., Jelić-Ivanović Z., Spasojević-Kalimanovska V.: Praktikum iz medicinske biohemije, Farmaceutski fakultet, Beograd, 2005.

3. Kovačević D.: Biohemija, Savremena administracija, Beograd, 2003.4. Marinkov Strahinja, Borota Jela: Medicinska biohemija, Radnički univerzitet „Radivoj Ćirpanov“, Novi Sad, 2007.5. Simić T., Marković I., Petronijević N., Isaković A.: Priručnik za exercises iz biohemije, Medicinski fakultet, Beograd,

2008.6. Marković I., Isaković A.: Energetski metabolizam kroz pitanja i odgovore, Medicinski fakultet, Beograd, 2008.7. Petronijević N., Misirlić Denčić S.: DNK, RNK i sinteza proteina kroz pitanja i odgovore, Medicinski fakultet, Beograd,

2008.8. Martin D. W., Mayers P.A., Rodwell V. W., Daryl G.: Harperov pregled biohemije, Savremena administracija, Beograd,

1992.9. Simić T., Petronijević N., Marković I., Isaković A., Radonjić N.: Biohemijske karakteristike prenosa signala kroz pitanja

i odgovore, Medicinski fakultet, Beograd, 2008.Number of active teaching: Other classes:Lectures: 45 Exercises: 45 Other forms of teaching: Students research work:Methods of teaching:interactive lectures, work in labs, workshops, seminars, discusions, case study



PHARMACEUTICAL TECHNOLOGY I

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Pharmaceutical Technology ITeacher:Subjects status: compulsorySemester: third year, sixth semesterECTS: 8Requirement: noSubjects objective: Introducing students to the basic principles of formulation, industrial processes in manufacturing and testing products such as powders, medicinal products for external and internal use type solutions, suspensions, emulsions, ointments, gels, creams, pastes and homeopathic preparations, training for the development of magistral and galenic preparations and their tests, using of literature.Subjects outcome:Student is trained to: know the Rules of the prescription and dispensing of medicines, known types, characteristics, methods of making, pharmaceutical and technological tests and requirements Pharmacopoeia for medicinal preparations type powders, medicinal products for external and internal use type solutions, suspensions, emulsions, ointments, gel, cream, pastes and homeopathic preparations; know the types, characteristics and use of excipients for the manufacture of medicinal preparations, know good pharmacy practice, be able to propose an appropriate pharmaceutical form in the galenic laboratory conditions based on the acquired knowledge.Subjects content:Lectures Definition of the subject, importance and general concepts, types and characteristics of dosage forms and medicinal preparations. Types and roles of excipients in the formulation of dosage forms. Importance of Good Pharmacy Practice. Types, properties, manufacture and testing of pharmaceutical technology medicinal preparations type powders, solutions, suspensions, emulsions, ointments, gels, creams, pastes and homeopathic preparations. Rheological properties of dosage forms.Practical classes Requirements for space and the organization of work in a pharmacy. Pharmacopoeia (domestic and foreign), manuals, registers of medicines. Getting to know the rules about making, storage and dispensing of medicines. The prescription and its parts. The

dosage of drugs, dosage validation and practical measures for dispensing drugs. Types, properties, manufacture and testing of pharmaceutical products and technology type powders, solutions, suspensions, emulsions, ointments, gels, creams, paste and homeopathic preparations.Literature: 1. Đurić Z.: Farmaceutska tehnologija sa biofarmacijom, I deo, udžbenik, Nijansa, Zemun, 2004.2. Jovanović M.: Praktikum iz farmaceutske tehnologije sa biofarmacijom, I deo, Nijansa, Zemun, 2003.3. Vuleta G.: Farmaceutska tehnologija sa biofarmacijom, priručnik za praktičnu nastavu: emulzije, suspenzije, polučvrsti

preparati za spoljašnju upotrebu, Nauka, Beograd, 2007.4. Remington G.: The Science and Practice of Pharmacy, Lippincott Williams & Wilkins, New York, 2005. 5. Swarbrick J., Boylan J. C.: Encyclopedia of Pharmaceutical Technology, Marcel Dekker Inc., NY, Basel, 2002.6. Voigt R.: Pharmazeutische Technologie, Deutscher Apotheker Verlag, Stuttgart, 2000.7. Allen L. V., Popovich N. G., Ansel H. C.: Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, Lippincot

Williams &Wilkins, Philadelphia, 2005.8. Ring H. P.: Drug Discovery and Development, Churchill Livingstone Elsevier, Edinburg, 2006.Number of active teaching: Other classes:Lectures: 75 Exercises: 90 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, Practical classes, problem based learning.



Drug Control and Analytics

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Drug Control and AnaliticsTeacher: Subjects status: compulsorySemester: fourth year, seventh semester ECTS: 8Requirement: Instrumental Pharmaceutical AnalysisSubjects objective:The acquisition of knowledge in the field of pharmaceutical analysis and drug conrol. Introduction to the basic legislation and the requirements of ICH, FDA, MHRA, USP, Ph. Eur. for pharmaceutical analysis and drug controlSubjects outcome: After passing the exam, the student is qualified to apply this knowledge in routine pharmaceutical analysis in laboratories for testing and control of the drug quality.Subjects content:LecturesThe legislation on the marketing of medications. Good manufacturing practice, good laboratory practice. ICH, FDA, MHRA, USP and Ph. Eur. European requirements for validation methods of pharmaceutical analysis. Standard operating procedures in pharmaceutical analysis and control of drugs. Statistical methods in analytics and drug control. Application of chemical, instrumental and non-instrumental methods in pharmaceutical analysis. Types of methods in qualitative and quantitative pharmaceutical analysis, quality control of official pharmaceutical ingredients and pharmaceutical products. The origin of impurities in pharmaceutical substances, classification and testing. Extraction methods in pharmaceutical analysis. Analysis of individual groups of drugs according to Eur., USP and other pharmacopoeia. Officinal methods. Titrimetric (acid-base titration, argentometric titration, iodometric titration, redox titration, complexometric titration, sediment titrations), spectroscopic (UV / VIS, IR, atomic, fluorescence, mass, raman, nuclear magnetic resonance), separation (HPLC, TLC, gas chromatography, capillary electrophoresis), thermal methods. Physico-chemical profile of pharmaceutical substances. Officinal chemical reactions, reactions of functional groups, derivatization for VIS spectrophotometric quality analysis, quantum officinal chemical reaction for VIS spectrophotometric analysis. Routine tests according to the monograph of officinal product. The degree of purity, stability.

Practical classesTesting and control of pharmaceutical substances by officinal pharmacopoeia or internally validated methods. The application of quantitative UV / VIS spectrophotometric analysis and titrimetric methods (acid-base titration, argentometric titration, iodometric titration, redox titration, complexometric titration, sediment titration). Quantitative determination of residues (gravity). Melting point in the identification and purity testing. Extraction: liquid-liquid extraction, liquid-solid extraction. TLC. Gas chromatography, capillary electrophoresis, HPLC, variety in the types of emitters.Literature: 1. European Pharmacopoeia, European Directorate for the Ouality of Medicine and Health Care, 7th ed., Strasbourg, 2010. 2. British Pharmacopoeia, The British Pharmacopoeia Secretariat, London, 2012.3. Satinder Ahuja, Stephen Scypinski: Handbook of modern Pharmaceutical analysis, Vol. 3, Academic Press, San Diego, 2001.4. Watson David G.: Pharmaceutical Analysis: A Textbook for Pharmacy Students and Pharmaceutical Chemists. 2nd ed., Elsevier,

Edinburgh, 2005. 5. Roth H. J., Eger K., Troschutz R.: Pharmaceutical chemistry, Vol. 2, Drug Analysis, Ellis Horwood, New York, 1991. 6. Živanović Lj.: Odabrane metode za farmaceutsku analizu, udžbenik, Nijansa, Zemun, 2003. 7. Ivanović D., Zečević M., Malenović A.: Analitika lekova, praktikum, Farmaceutski fakultet, Beograd 2004.Number of active teaching: Other classes:Lectures: 60 Exercises: 45 Other forms of teaching: Students research work:Methods of teaching:interactive lectures, laboratory exercises, e-learning, computer simulation


Lectures 5 Exame 50Practical classes 30Colloquiums 15 Seminars 0

PhytotherapyStudy programes: pharmacy Type and level of study: integrated academic studiesName of subject: PhytotherapyTeacher: Subjects status: compulsorySemester: fourth year, seventh semesterECTS: 3Requirement: Pharmacognosy IISubjects objective:Providing knowledge about place and role of phytotherapy in primary health care system and self-medication, herbal remedies (active components are herbal drugs or preparations of herbal drugs), validity of their use for recovery, preservation and improvement of health. Subjects outcome: Student should know principles of rational phytotherapy, active components of herbal remedies and mechanisms of action of active ingredients, carry out procedures for provision and control of quality of active ingredients and herbal remedies, suggest active component(s) of herbal remedies, build a critical attitude towards certain herbal remedies, evaluate benefit/harm ration of herbal remedies, know indications, contraindications, adverse effects and interactions of herbal medicines, provide valid information and patient counseling about usage of herbal medicines.Subjects content:LecturesGeneral part. Definition of term Phytotherapy and usage of herbal medicines through rational and traditional phytotherapy, herbalism and homeopathy. Definition of self-medication and role and importance of herbal medicines. Definition of herbal medicines and informing about relevant laws and regulations. Types of herbal medicines. Provision of quality of herbal medicines. Basic information about other relevant herbal products in medicine and pharmacy (dietary and cosmetic products).Special part. Safe application of herbal medicines: indications, dosage, contraindications, adverse effects, precautions, tips, interactions. Herbal medicines appliance to the functional disorders and diseases of central nervous system, cardiovascular system, respiratory, gastrointestinal, genitourinary tract, skin and mucosa, metabolism disorders. Herbal medicines with immunomodulatory, adaptogenig, anti-inflammatory, antimicrobial, antioxidant and citostatic activity.Practical classes Analysis and control of the quality of herbal medicines: analysis of tea mixtures, identification and analysis of active components of herbal medicines. Analysis of instruction for usage of herbal medicines. Case study analysis. Literature:1. Conway Peter, The Consultation in Phytotherapy, Churchil Livingstone, Elsevier, 2010.2. Schulz V., Haensel R., Tyler V. E.: Rational Phytotherapy, Springer, Berlin, 2001. 3. Blumenthal M. (еd.): The ABC Clinical Guide to Herbs, American Botanical Council, Austin, 2003.4. ESCOP Monographs, Georg Thieme Verlag, Stuttgart, 2003. 5. Heinrich M, Barnes J, Gibbons S.: Williamson E. Fundamentals of Pharmacognosy and Phytotherapy, Churchill

Livingstone, Edinburgh, 2004. Number of active teaching: Other classes:Lectures: 15 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:lectures, analysis of case studies, practical classes.



PHARMACOKINETICS WITH PHARMACODINAMICS

Study programs: pharmacy, medical biochemistryType and level of study: integrated academic studiesName of subject: Pharmacokinetics and PharmacodynamicsTeacher: Subjects status: compulsorySemester: fourth year, seventh semesterECTS: 3Requirement: PharmacologySubjects objective: To understand kinetic processes on drugs throughout body, kinetic analysis and importance of pharmacokinetic parameters in defining and/or correction of dosing regimen of drugs with the aim of rational pharmacotherapy.Subjects outcome:After completion of the exam it is expected that a student: knows pharmacokinetic processes and factors that influence these processes, knows different approaches in pharmacokinetic data analysis, estimates/calculates pharmacokinetic parameters (singl and multiple doses), knows factors that influence variability of therapeutic response, knows ways for analysis of bioavailability and bioequivalence of medicinal preparations, estimates need for drug therapy monitoring, interpret measured drug concentrations, knows and applies principles of clinical pharmacokinetics.Subjects content:LecturesGeneral pharmacokinetics (pharmacokinetic processes on drugs throughout body, resorption, distribution, metabolism and elimination – ADME system). Pharmacokinetic data analysis from plasma and calculating pharmacokinetic parameters (i.v. and e.v. application of drug – one- and two-compartment model; non-compartment – model independent; population analysis; pharmacokinetic-pharmacodynamic modeling and other analysis; repeated doses – steady state; preparations with modified liberation of drug – depot preparations). Pharmacokinetic data analysis from urine. Bioavailability and bioequivalence of drugs. Clinical pharmacokinetics (factors that lead to pharmacokinetic variability; principles of clinical pharmacokinetics; drug safety – interactions and adverse effects of drugs, pharmacovigilance)Practical classes Biomaterials for pharmacokinetic and drug metabolism analysis (in vivo and in vitro). Isolating (extraction) of drugs and metabolites from biological material. Bioanalytical methods in pharmacokinetic analysis and parameters for evaluation of bioanalytical methods. Pharmacokinetic data analysis and calculating pharmacokinetic parameters from plasma and urine. Control of in vivo pharmacokinetic analysis (e.g. plasma, urine). Basics of clinical pharmacokinetics (clinical-pharmacokinetic calculations).Literature: 1. Pokrajac M.: Pharmacokinetics, textbook, 3rd ed., Faculty of Pharmacy, Belgrade, Birograf, Belgrade, 2007.2. Pokrajac M.: Pharmacokinetics – handbook for practical work, 2nd ed., Faculty of pharmacy, Belgrade, Grafolik, Belgrade,

2001.3. Ritchel W., Kearns G.: Handbook of Basic Pharmacokinetics, 6th ed., APhA Publications, Washington, 2004.4. Watson C. S., Zivadinovic D., Bulayeva N., Hawkins B., Campbell C., Gametchu B. i sar.: The Identities of Membrane Steroid

Receptors (ed.: Watson C. S.), Kluwer Academic Publishers, Boston, 2003.Number of active teaching: Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, e-learning, Practical classes, workshopsе, case study, analysis of the problem.



Seminars 0

PHARMACEUTICAL TECHNOLOGY II

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Pharmaceutical Technology IITeacher:Subjects status: compulsorySemester: fourth year, seventh semesterECTS: 5Requirement: Pharmaceutical Technology ISubjects objective:Introduction to the types, composition and properties of conventional and new dosage forms for oral (capsules, tablets), parenteral (injections, infusions, concentrates, implants), ophthalmology, rectal and vaginal use, pharmaceu-tical forms for inhalation, modified release formulations of the drugs, therapeutic systems. Learn about new trends in the formulation of biotech drugs, meeting with technological engineering methods, pharmacopoeia requirements, in -troducing auxiliary substances and colloidal drug carriers, active substances. Training in the use of literature, writing reports of the characteristics of the tested drug.

Subjects outcome:It is expected that the student knows the types, composition, formulation, technological processing methods and means of storage (storage conditions) of solid dosage forms, parenteral products, pharmaceutical forms for ophthalmology, rectal and vaginal use, an inhalant, modified release formulations of the drugs. That he or she can provide information to the patient, analyze and interprete the results and have the skills to formulate dosage forms and recognize basic excipients in pharmaceutical practiceSubjects content:LecturesSterilization and sterilization methods. Isotonic solutions. Parenteral preparations and preparations for the eyes. Im-munobiological preparations (serums and vaccines). Radiopharmaceutical preparations. Solutions for hemodialysis and peritoneal dialysis. Inhalation preparations, capsules, tablets, preparations for rectal and vaginal use. Modified re-lease formulations of drug for oral and parenteral application. Preparations with protein and other biotechnological active substances. Therapeutic systems for ophthalmology, intrauterine or intra-vaginal, oral, parenteral, pulmonary, buccal, nasal and transdermal application. Therapeutic systems targeted drug release. Colloidal drug carriers.Practical classesSterile medical products, sterilization, methods. Getting to know the terms of the process of developing aseptic prepa-ration. Preparation and pharmaceutical-technological testing of eye products and parenteral preparations. Preparations for inhalation, a demonstration of application. Pharmacy tech test: capsules, tablets, suppositories, pessaries, modified release formulations of the drugs. Therapeutic systems.Literature: 1. Đurić Z.: Farmaceutska tehnologija sa biofarmacijom, I deo, udžbenik, Nijansa, Zemun.2. Jovanović M.: Praktikum iz farmaceutske tehnologije sa biofarmacijom, I deo, Nijansa, Zemun, 2003.3. Milić J., Primorac M., Stupar M.: Priručnik za praktičnu nastavu, Grafopan, Beograd, 2005.4. Allen L. V., Popovich N. G., Ansel H. C.: Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, Lippincot

Williams &Wilkins, Phyladelphia, 2005.5. Parojčić J., Ibrić S., Đurić Z.: Farmaceutska tehnologija sa biofarmacijom, Priručnik za praktičnu nastavu, Konstisi, Beograd,

2006.6. HP: Drug Discovery and Development, Churchill Livingstone Elsevier, Edinburg, 20067. Jiskoot W., Crommelin D. J. A.: Methods of Structural Analysis of Protein Pharmaceuticals, American Association of

Pharmaceutical Scientists (AAPS), Arlington, 2005.8. Crommelin D. J. A., Sindelar R. D.: Pharmaceutical Biotechnology: an introduction for pharmacists and pharmacutical

scientists, Taylor & Francis, Philadelphia, 2002.Number of active teaching: Other classes:Lectures: 45 Exercises: 60 Other forms of teaching: Students research work:

Methods of teaching: interactive lectures, practical classes, problem-based learning.



COSMETOLOGY

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Cosmetology Teacher: Subjects status: compulsorySemester: fourth year, seventh semesterECTS: 3Requirement: Pharmaceutical Technology ISubjects objective: Getting to know: regulations on cosmetic ingredients (raw materials), cosmetic and dermocosmetic products, the most important raw materials for the production of cosmetic and dermocosmetic product carriers for cosmetically active substance (CAS), the possibilities of application of nano and other new technologies, types, forms, methods of making and testing of cosmetic and dermocosmetic products, cosmetics and dermocosmetic effects to the skin and skin adnexis, consideration of environmental aspects, the provision of appropriate advice and recommendations on how to use and possible side effects of cosmetic and dermocosmetic products. Subjects outcome: Knowledge of legislation on cosmetic raw materials, cosmetic and dermocosmetic products, knowledge of new technologies, types, shapes, manufacturing and testing procedures, as well as the effects of cosmetic and dermocosmetic to the skin and the environment; the ability to critically evaluate marketing information on the effect of cosmetic raw materials and products, the ability to assess desired / potential adverse effects of various dermocosmetic products.Subjects content:LecturesDefinition of the subject, the connection to pharmacy and medicine, legal regulations and quality assurance of cos-metic ingredients, cosmetic and dermocosmetic products, cosmetic ingredients / raw materials for the production of cosmetic and dermocosmetic products, nano and other emerging technologies in cosmetics, modern carriers of CSA in cosmetic / dermo-cosmetic preparations, beauty products for cleaning / washing, skin care and protection; dermocosmetic products in the prevention and treatment of skin aging, mature skin, sun protection of the skin, baby skin care and baby skin, beauty / dermocosmetic products for the treatment of scalp and hair, beauty prepara -tions for the teeth and oral cavity; deodorants and antiperspirants, procedures for manufacturing and testing of cos -metic / dermocosmetic products, assessment of effects, safety and tolerability of dermocosmetic to the skin and the environment.Practical classes Formulation, development and testing of cosmetic products: cleansing, skin care and protection; hair treatment; dental hygiene and oral cavity; deodorant and antiperspirant products and certain dermocosmetic products. Literature:1. Vasiljević D., Savić S., Đorđević Lj., Krajišnik D.: Handbook of cosmetology, Nauka, Beograd, 2007. 2. Vuleta G.: Pharmaceutical technology with biopharmacy, handbook for practical classes: emulsions, suspen-

sions, semisolid products for outer use, Nauka, Belgrade, 2007. 3. Vuleta G.: Cosmetology, textbook, Nauka, Belgrade, 1994. 4. Rieger M. M., Harry's Cosmetology, 8th ed., Chemical Publishing Co. Inc., New York, 2000.5. Mazić Senka: Cosmetology, modern cosmetical raw materials, textbook, Medical College, Belgrade, 2001.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:

Methods of teaching: interactive lectures, practical classes, problem-based learning.



Pharmacotherapy

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: PharmacotherapyTeacher: Subjects status: compulsorySemester: fourth year, eighth semesterECTS: 6Requirement: PharmacologySubjects objective: To provide students: information necessary to recapitulate certain diseases and understand certain treatment options, contemporary evidence of the efficacy and safety of drugs for certain diseases, knowledge necessary for critical evaluation of drugs, the skills necessary for the critical evaluation of signs and symptoms presented by the patient in the pharmacy.Subjects outcome:Upon completion of the course, students will be able to:understand and differentiate pathophysiology, clinical presentation, clinical course, prognosis and pharmacological and non-pharmacological treatment of various diseases, compare the ratio of therapeutic efficacy / potential for causing damage to certain drugs intended for the same problems / disease, support patients and health professionals with evidence-based information and advices on the use of drugsSubjects content:Lectures Pharmacotherapy in nephrology, pulmonology, endocrinology, gynecology and obstetrics, oncology, gastroenterology, neurology, rheumatology, psychiatry, dermatology. Pharmacotherapy of cardiovascular disease. Pharmacotherapy of infectious diseases. Pharmacotherapy of anemia and blood disorders. Pharmacotherapy of pain. Pharmacotherapy of vitamins and minerals and dietary supplements. Antibiotic therapy. Immunomodulatory therapy. Pharmacotherapy in pediatrics. Pharmacotherapy in geriatrics. Specifics of pharmacotherapy in women. Homeopathic therapy. Specifics of pharmacotherapy in athletes. OTC products.Practical classesRole of pharmacists in pharmacotherapy of specific diseases, systems and conditions. The role of pharmacists in the optimal use of OTC productsLiterature: 1. DiPiro Joseph T., Schwinghammer Terry L.: Pharmacotherapy: A Pathophysiologic Approach, 6th ed., McGraw-Hill

Medical, New York, 2005.2. Rutter P.: Community Pharmacy: Symptoms, Diagnosis and Treatment, 2nd ed., Churchill Livingstone, Edinburg, 2008.3. Jakovljević V., Sabo A., Tomić Z. (ured.), Stević S. i sar.: Lekovi u prometu 2009, priručnik o lekovima i njihovoj primeni,

ATC klasifikacija, 2. izd., Novi Sad, Beograd, Niš, Kosovska Mitrovica, Podgorica, Ortomedics, Novi Sad, 2007, 2009.Number of active teaching: Other classes:Lectures: 30 Exercises: 45 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, case studies, workshops, e-learning, problem analysis.



Toxicology with Analytics

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Toxicology with analyticsTeacher: Subjects status: compulsorySemester: fourth year, eighth semesterECTS: 2Requirement: PharmacologySubjects objective:Introducing, acquiring, understanding, application, analysis and evaluation of knowledge and skills in general toxicology and the most important representatives of different toxins in toxicology, (forensic toxicology, occupational toxicology, clinical toxicology, food toxicology, drug toxicology, ecotoxicology, analytical toxicology).Subjects outcome: Possibility for qualified pharmacists to work in a field of: toxic effects of drugs and means of enjoyment, occupational poisoning, environmental pollution, regulations in toxicology, what makes a pharmacist one of the important links in preserving the health of the general population.Subjects content:LecturesGeneral Principles of Toxicology: Definition of poison, dose-response relationship, toxicity factors, kinetics of toxins, the effects of toxins in the body, mechanisms of toxicity, the basic principles of treatment of poisoning and antidotes, selection and preparation of materials, methods of qualitative and quantitative analysis of poisons in toxicological practice, the interpretation of the results with regard to our and international legislation. The most important poisons on the basis of systematic research criteria: gaseous, highly volatile, mineral, herbal and synthetic toxins: their chemical properties, separation, mechanisms of toxicity, metabolism, target organs of toxicity, first aid basis and treatment in poisoning, antidotes, analytics, interpretation of results and their importance in different areas of toxicology. Fundamentals of ecotoxicology and the most important pollutants of the atmosphere, hydrosphere and lithosphere; principles of risk assessment. Toxicology of drugs: drugs as the most common cause of poisoning (benzodiazepines, phenothiazines, etc.). Toxicology of pesticides. Toxicology of chemical weapons. Legislation in the field of toxicology.Practical classes Practical teaching is an integral continuation of theoretical lectures and designed with the goal that students master the complete procedure of toxicological analysis: choice of material for toxicological analysis, performance and significance of toxicity tests, calculation and interpretation of toxicokinetic parameters, methods of identification and determination of major ecopollutants, drugs, poisons and their metabolites in biological samples, interpretation of results, the basic principles of risk assessment to human health.Literature:1. Mokranjac St. M. Toxicological Chemistry, tutorial, Grafopan, Belgrade, 2001th2. Djuric B. D., Petrovic J. Lj.: Environmental pollution and human health, ed.: Raznatovic T. M. Velarta, Belgrade, in 1996.3. Jokanović M.: Toxicology, ed.: M. Gavrilovic, tutorial, Elite Medica, Belgrade, 2,001th4. Matović V., M. Djukic, Antonijevic B., D. Vujanovic, pennant-Bulat Z.: Practicum in toxicological chemistry, ed. Matović

V., Paragon, Belgrade, 2005.Number of active teaching: Other classes:Lectures: 45 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, practical work in groups,group projects



BIOPHARMACY

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: BiopharmacyTeacher: Subjects status: compulsorySemester: fourth year, eighth semesterECTS: 4Requirement: Pharmaceutical Technology ISubjects objective: The objective of theoretical and practical classes of Biopharmcy is for students to gain adequate knowledge about: the impact of physical, chemical, biological and pharmaceutical-technological factors on the process; drug release from the dosage form / medical products, the concept of a biopharmaceutical drug classification system (BCS) methodology of in vitro testing of dissolution rate of drug from medicinal products.Subjects outcome: It is expected that students know and understand the concepts and definitions related to the impact of biological, physical, chemical and pharmaceutical - technological factors on the release and absorption of drug from the dosage form; know how to evaluate the impact of certain factors and applying them in the formulation of dosage forms; know and understand the basic theoretical principles and application of the BCS and be able to, using literature and experimental data, suggest a model in drug classification according to BCS; know the importance and possibilities of testing of the release of drug from medicinal forms, as well as the basic principles of the establishment and application of the concept in vitro - in vivo correlations; think critically about the choice of the experimental conditions during the development of the test for studying the rate of dissolution of drug from medicinal products; know how to communicate in writing with the use of relevant literature present results and discuss the experimental work.Subjects content: LecturesDefinition, basic concepts and case studies biopharmacy. The influence of biological, physical, chemical, and pharmaceutical-technological factors on the release rate and absorption of medicinal substances from medicinal products. Biopharmaceutical classification system of drugs. Planning medicinal products with the desired drug release. The mechanism and kinetics of drug release from various medicinal products. In vitro testing of kinetics of drug release from the drug forms. Principles of development of biorelevant in vitro test; vitro - in vivo correlation.Practical classesTesting, identification and / or assessment of factors relevant to the kinetics of drug release from the drug forms (the degree of ionization and the pH value, the partitioning coefficient, solubility, dissolution rate, particle size). Dissolution rate of drug from medicinal forms (Dissolution test). Analysis of the influence of experimental conditions on the dissolution rate of drug from medicinal forms. The development of methods for studying the rate of dissolution of drug from medicinal forms. Comparison of the release profiles. Classification of substances according to the BCS. In vitro - in vivo correlation. The use of pharmacokinetic simulators.Literature:1. Đurić Z.: Farmaceutska tehnologija sa biofarmacijom, I deo, udžbenik, Nijansa, Zemun, 2004.2. Đurić Z., Parojčić J.: Praktikum iz biofarmacije, Nijansa, Zemun, 2004.3. Rowland M., Tozer T. Clinical

Pharmacokinetics: Concepts and applications, 3rd ed., Lea & Febiger, Philadelphia, 1995.4. Shargel L., Yu A. B. C.: Applied Biopharmaceutics and Pharmacokinetics, 4th ed., Appleton & Lange, Stamford, CT, 1999.5. Aulton M. E.: Pharmaceutics: The Science of Dosage Form Design, 3rd ed., Churchill Living., Edinburgh 2002.6. Gibaldi M.: Biopharmaceutics and Pharmacokinetics, 4th ed., Lea & Febiger, Philadelphia, 1991.Number of active teaching: Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, practical exercises, case study, e-learning.



Seminars 0

PHARMACEUTICAL BIOTECHNOLOGY

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Pharmaceutical BiotechnologyTeacher:Subjects status: compulsorySemester: fourth year, eighth semesterECTS: 5Requirement: Pharmaceutical Technology I, Molecular Biology of CellSubjects objective: Introduction to all the relevant aspects of the development of new drugs based on biotechnology, ranging from drug discovery and identification of target organs and tissues, through pre-clinical and clinical studies, processing to the final formulation, industrial production and marketing. Informing the student about the application of modern and innovative approaches, techniques and methods in various fields of pharmaceutical biotechnology, design and optimization of drugs, in cosmetics, diagnostics and vaccine production, as well as the development of biomaterials for tissue and organ replacement. Introduction to the latest developments resulting from the rapid development and expansion of biopharmaceuticals based on recombinant DNA, RNA and proteins, whose application has received additional impetus in early postgenome era. Learning to critically evaluate information on biotech drugs, safety of their use and ethical aspects related to this area. Course objectives are defined taking into account the requirements of both domestic and international companies working in the field of research and development of drugs and vaccines. Developing the ability to use speciliazed literature and preparation of written and oral reports (seminar papers, interactive discussions).Subjects outcome:After passing the exam, students will: be able to work independently on an innovative application of modern biotechnology in the pharmaceutical field, the diagnosis, the production of biomaterials, vaccines, and in cosmetics. Students will gain a thorough knowledge of and ability to apply the methodology for the production, development, analysis, and pharmacological and toxicological evaluation of biotechnological molecules and biomaterial of pharmaceutical, diagnostic and cosmetic importance, knowledge of relevant legal, ethical and security aspects of the application of biotechnology pharmaceutical biotechnology, the ability to use and critically evaluate primary specialized literature.Subjects content: Lectures Pharmaceutical biotechnology: introduction, history and prospects of future development. Fundamentals of molecular biotechnology. Eukaryotic and prokaryotic cells, gene expression, recombinant DNA technology. Fundamentals of genomics, transcriptomics and proteomics and their application in the discovery of new biotech drugs. Application of bioinformatics in pharmaceutical biotechnology. The structure of proteins. Techniques for preparation, purification and characterization of protein stability. Formulation of biotech drugs. Protein distribution, routes of administration and improvement of absorption. Fasteners and mechanisms for targeted delivery of protein drugs, mechanical pumps, osmotic-dependent systems, bio-degradable microspheres, biosenzorne pumps, self-regulating systems for the distribution of proteins, microencapsulated cells for the distribution of secretory proteins, colloidal particle systems for targeted delivery of proteins. Excipients in the formulation of biotech drugs for parenteral use. Shelf-life of protein drugs. Microbiological aspects of protein drugs. Monoclonal antibodies as targeted carriers, human and humanized antibodies, biospecific antibody immunoconjugate. The development of biotechnological vaccines. Gene Therapy. Using recombinant DNA technology in obtaining / producing drugs in the example of insulin, human growth hormones, vaccines for hepatitis B, interferon, interleukin, etc. Legislation in the patent and registration of biotech drugs and prescription of biotech drugs. Ethical aspects and safety of production and application of biotech drugs.Practical classesOrientation of biotechnology to the pharmaceutical industry and scientific approach to the development of new protein drugs; new protein drug candidates, the isolation of proteins on lab-level and protein sequencing. Cloning of the genes. Development of systems for the production of proteins by recombinant DNA technology. Isolation and purification of recombinant proteins. The development of pharmaceutical forms of the recombinant protein. Preclinical and clinical studies in order to obtain FDA certification.

Literature: 1. Groves M. J. (ed.): Pharmaceutical Biotechnology, 2nd ed., CRCPress Taylor Francis Group, Boca Raton,

Philadelphia, 2006. 2. Kayser O., Mueller R. H. (eds.): Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications, Wiley-

VCH Verlag GmbH & Co. KGaA, Weinheim, 2004.3. Rho J. P., Louie S. G. (eds.): Handbook of Pharmaceutical Biotechnology, Pharmaceutical Products Press,

Binghamton, New York, 2003.4. Crommelin D. J. A., Sindelar R. D. (eds.): Pharmacеutical Biotechnology, 2ndеd., Taylor & Francis Inc.,

Philadelphia, 2002.5. Klefenz H.: Industrial Pharmaceutical Biotechnology, Wiley, Chichester, 2001.6. Banga A.: Therapeutic peptides and proteins, Formulation processing and delivery systems, Technomic Lancaster,

Pennsylvania, 1995.Number of active teaching: Other classes:Lectures: 45 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:lectures, computer simulations, interactive work, e-learning.



PHARMACEUTICAL ETHICS AND LAW

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Pharmaceutical Ethics and Law Teacher: Subjects status: compulsorySemester: fourth year, eighth semesterECTS: 2Requirement: noSubjects objective:Mastering the basics of applied ethics in pharmacy; understanding the practical importance of ethics in the pharmaceutical sector and knowledge of the difference between ethical and legal issues, developing critical thining in the process of ethical analysis, understanding national, European and international legislation, knowledge of the rights and obligations of health care and health insurance (mandatory and other forms of insurance), and the rights and obligations of providers, users and third parties.Subjects outcome:After passing the exam, the student will be able to assess which of the normative principles is important in resolving the situation in practice, think critically about them, know the difference between legal and ethical issues, possess the knowledge to critically assess whether every situation of giving health service involves moral duty, they will know and will be able to apply the laws that govern aspects of health care services, the rights and obligations of health care workers (pharmacists), patients and third parties.Subjects content: Lectures Normative ethics in pharmacy. Ethical principles relevant to the pharmaceutical profession. Ethical theories of pharmaceutical ethics. Ethical norms in pharmaceutical practice. Ethical analysis of cases from the pharmaceutical health care practices, moral values, wrong judgment. Errors in pharmacy, moral and criminal responsibility of the pharmacist. Ethical reasoning in respecting moral values and rights of patients. Failure to comply with the codified principles. Ethics in preclinical and clinical trials (baseline). Ethics Committee. Ethics in the pharmaceutical industry and marketing of drugs. European and international regulations. National health care policy, regulation of health care. Medicines and Medical Devices Agency of Serbia. Procedure for registration of drugs and medical devices. Pharmaceutical Regulations. Pharmaceutical Chamber of Serbia. Pharmacist's license. Court of Honor.

Practical classesAnalysis and discussion of case studies (generation and critical evaluation of information and data). Problem-based learning (problem solving with explanation of the concept of ethical and legal framework). Panel discussions, the use of ethics and law in current issues (keeping patient and medication information, dispensing, drug abuse, drug use confidential).Literature: 1. ICH regulativa i regulativa EU koje se odnose na sve aspekte leka, zdravstvenog osiguranja i prava i obaveza farmaceuta u

pružanju farmaceutske zdravstvene zaštite. 2. Aktuelni zakoni i podzakonska akta Republike Srbije iz oblasti zdravstva.3. Parojčić D.: Etika u farmaciji, udžbenik, Galerija farmaceutskih veština, Placebo, Beograd, 2005.4. Grujić V., Martinov Cvejin M., Legetić B.: Socijalna medicina, udžbenik, Medicinski fakultet, Novi Sad, 1991.5. Grujić V., Martinov Cvejin M., Legetić B.: Ekonomika zdravstva, Medicinski fakultet, Novi Sad, 1993.6. Veatch R., Haddad A.: Case Studies in Pharmacy Ethics, Oxford University Press, New York, 1999. 7. Beachamp T. L., Childress J. F.: Principles of Biomedical Ethics, 5thed., Oxford University Press, New York, 2001.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:interactive lectures, workshops, case study, problem-based learning.



Endocrinology

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: EndocrinologyTeacher: Subjects status: compulsorySemester: fourth year, eight semesterECTS: 3Requirement: Physiology II, General Biochemistry IISubjects objective:The objective of the course is to provide students with acquiring the knowledge in the field of endocrinology, as well as the application of basic laboratory methods in the diagnosis of functional disorders of the endocrine system.Subjects outcome: Upon passing the exam in this subject, the student is able to understand the principles of action of the endocrine system and is acquainted with the most important analysis applied in the laboratory diagnostics of disorders of the endocrine system. Special emphasis is given to the application of knowledge for pharmaceutical purposes.Subjects content:LecturesThe organization of the endocrine system. Synthesis, storage and secretion of hormones. The mechanisms of action of hormones. Hypothalamic control of anterior pituitary. Hypothalamic control of posterior pituitary. The pineal gland. Thyroid gland. The adrenal glands. Testis and ovary. Endocrine regulation of growth. Endocrine regulation of calcium. Endocrine regulation of glucose and lipid metabolisms. Endocrine control of reproduction. Endocrine function of non-endocrine organs. Hormones and carcinogenesis. Geriatric endocrinology. Practical classesHistological technique in investigating the structure and function of the endocrine glands. Histology and histopathology of the endocrine glands. Principles of the endocrine system organization (computer simulation). Structure of the endocrine glands and function of their hormones (computer simulations). Methods of investigation for endocrine function under in vivo and in vitro conditions.Literature:1. Matavulj M., Kostić T., Andrić S.: Endokrinologija, udžbenik, Univerzitet u Novom Sadu, 2005.

2. Marić D., Stojilković S.: Opšta fiziologija, udžbenik za studente biologije, 2. izd., Univerzitet u Novom Sadu, 1991.3. Stojilković Stanko i sar.: The Encyclopedia of Hormones (eds.: Henry H. L., Norman A. W.), Academic Press, New

York, 2003.4. Bolander F. F.: Molecular Endocrinology, Elsevier Academic Press, Waltham, Massachusetts, 2004. 5. Neal M. J.: How Endocrine System Works, Blackwell Science Inc., Hoboken, New Jersey, 2002. 6. Greenspan Francis S., Gardner David G.: Basic and Clinical Endocrinology, 7th ed., McGraw-Hill Company,

Columbus, Ohio, 2004.7. Johnstone M., Aristides Veres: Diabetes and Cardiovascular Disease, 2nd ed., The American Association for Clinical

Chemistry, New York, 2005.Number of active teaching Other classes:Lectures: 30 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:lectures, Practical classes combined with computer animations, exercises, case study



INDUSTRIAL PHARMACY

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Industrial PharmacyTeacher: Subjects status: compulsorySemester: fifth year, ninghth semesterECTS: 2Requirement: Pharmaceutical Technology IISubjects objective:That students know and understand the principles and characteristics of industrial production of drugs in terms of developing the medicines, drug stability, regulatory requirements, providing conditions for the production of drugs, types and selection of equipment used in the manufacture of drugs, quality systems and quality assurance;Subjects outcome: After passing the subject, the student is trained in applying the information necessary for the formulation, development and stability of the medicinal products in development laboratories in the pharmaceutical industry, knowledge of contemporary requirements for quality systems in the pharmaceutical industry, knowledge of the principles of operation and types of devices used in the pharmaceutical industry in the development of medicinal preparations.Subjects content:LecturesQuality Assurance. Basic concepts and definitions. Standardization. International ISO standards, European standards are important for the production and distribution of drugs. Good manufacturing practices in the production, storage and distribution of medicines, the active pharmaceutical ingredients and excipients, distribution and storage. Basic concepts reformulation and formulation of medicinal preparations in the development laboratories of pharmaceutical industries. Formulation and development of conventional and modern medicinal preparations, tendencies. Incompatibilities in the formulation. Stabilization. The transfer procedure for the preparation of medicinal preparations from laboratory conditions to industrial production. Pharmaceutical unit operations in the production of medicinal preparations. Shredding and screening, devices. Mixing and blending equipment for the preparation of medicinal preparations. Homogenization in the preparation of medicinal products in the pharmaceutical industry equipment. Thermal operations in the preparation of medicinal products in the pharmaceutical industry. Drying apparatus for drying in the preparation of medicinal products. Filtration and filtration equipment for the preparation of sterile and non-sterile medicinal products. Compression devices and compression. Filling and packaging of medicinal preparations. Practical classes

Quality Assurance. Examples from practice. Implementation of the principles of good manufacturing practice and quality management system requirements (ISO 9001). The formulation of medicinal preparations. Independent seminar on the formulation given dosage form. Tasks related to stabilization and determination of shelf life of medicinal preparations. Pharmaceutical unit operations. Demonstrative exercise of the display device for chopping, mixing, homogenization and compression in the laboratory. A demonstration of the device for chopping, mixing, homogenization, heat transfer operations, drying, filtration, compression, filling and packaging. Computational exercises. Professional excursions.Literature: 1. Jovanović Milica, Đurić Zorica: Osnovi industrijske farmacije, udžbenik, Nijansa, Zemun, 2005.2. Carstensen J.: Drug Stability, 2nd ed., Marcel Dekker, New York, 1995.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:interactive lectures, practical exercises, demonstrative practical exercises, calculation exsercise



Drug Interactions and Side Effects

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Drug Interactions and Side EffectsTeacher: Subjects status: compulsorySemester: fifth year, ninghth semesterECTS: 2Requirement: PharmacologySubjects objective: Student will understand the kinetic processes by which drug in the body succumbs to the kinetic analysis, understand the importance of pharmacokinetic parameters in setting up and / or correction of the dosing rational pharmacotherapy, know the factors that affect the variability of treatment response, assess the need for therapeutic drug monitoring, interpret measured doses of medication and know and apply principles of clinical pharmacokinetics.Subjects outcome:After passing the exam, the student will know the pharmacokinetic processes and factors that affect them, know about different approaches to the analysis of pharmacokinetic data, estimate and calculate pharmacokinetic parameters (single and repeated doses), know the factors that affect the variability of treatment response, know the ways of bioavailability and bioequivalence of medicinal preparations, assess the need for therapeutic drug monitoring, interpret measured concentrations of drugs, know and apply the principles of clinical pharmacokinetics.Subjects content:LecturesGeneral pharmacokinetics (pharmacokinetic processes by which the body is subject to drug: absorption, distribution, metabolism and excretion of drugs - ADME system). Pharmacokinetic analysis of plasma data and calculation of pharmacokinetic parameters (drug use - single-space and dvoprostorni model; non-spatial model independent; population analysis, pharmacokinetic-pharmacodynamic modeling and other analyzes; repeated dosing - a state of balance; preparations in modified release drug - depot preparations). Pharmacokinetic analysis of data from the urine. Bioavailability / bioequivalence of drugs. Clinical pharmacokinetics (factors that cause pharmacokinetic variability; clinical pharmacokinetic principles; drug safety - interactions and side effects of drugs, pharmacovigilance).Practical classes Biological materials for pharmacokinetic studies and testing drug metabolism (in vivo and in vitro). Isolation (extraction) of drugs and metabolites in biological material. Bio-analytical methods in pharmacokinetic studies and to assess the bio-analytical methods. Pharmacokinetic data analysis and calculation of pharmacokinetic parameters from plasma and urine. Control of in vivo pharmacokinetic studies (examples: plasma, urine). Fundamentals of clinical pharmacokinetics (clinical pharmacokinetic

calculations). Computer simulation of pharmacokinetic and pharmacodynamic calculations. Reports of adverse effects of the drug, the analysis and discussion. Analysis of statistical data. Literature: 1. Pokrajac M.: Farmakokinetika, 3. izd., udžbenik, Farmaceutski fakultet, Beograd, Birograf, Beograd, 2007.2. Pokrajac M.: Farmakokinetika - Priručnik za praktičnu nastavu, 2 izd., Farmaceutski fakultet, Beograd, Grafolik, Beograd,

2001.3. Jakovljević V., Sabo A., Tomić Z. (ured.), Stević S. i sar.: Lekovi u prometu 2009, priručnik o lekovima i njihovoj primeni,

ATC klasifikacija, 2. izd., Novi Sad, Beograd, Niš, Kosovska Mitrovica, Podgorica, Ortomedics, Novi Sad, 2007, 2009. 4. Kearns G.: Handbook of Basic Pharmacokinetics, 6th ed., APhA Publications, Washington, 2004.5. Rosenbaum Sara E.: Basic Pharmacokinetics and Pharmacodynamics, An Integrated Textbook and Computer Simulations,

JohnWiley & Sons, New York, 2011.6. Stockley Ivan (ed.): Stockley's Drug Interactions, 6th ed., Pharmaceutical Press, London, 2002.7. Dictionary of Pharmacovigilance, Pharmaceutical Press, London, 2004.8. Jakševac-Mikša M. (ur.): Interakcije lekova, priručnik (prema: Zucchero F. J., Hogan M. J. (eds.), Washington: APA,

Evaluations of Drugs Interactions), 2nd ed., HFD, Zagreb, 1998.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, analysis of selected examples of drugs, workshops, case study



CLINICAL PHARMACY

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Clinical PharmacyTeacher: Subjects status: compulsorySemester: fifth year, ninghth semesterECTS: 9Requirement: PharmacologySubjects objective:Application of the principles of clinical pharmacy in improving health of the patient and society.Subjects outcome:Upon completion of the course, students will be able to: understand and apply the concept of evidence based medicine / pharmacy; critically evaluate sources of information about drugs; apply principles of clinical pharmacokinetics to implement a rational pharmacotherapy. Identify, assess and resolve problems with the drug administration; apply an individual approach to the patient, monitor and advise patients about drug administration. Communicate with health care professionals and patients on rational pharmacotherapy and health promotion. Implement, monitor and evaluate the treatment in order to ensure rational pharmacotherapy.Subjects content:Lectures:The concept of pharmaceutical care (PC) in primary health care, the role of the pharmacist in hospital practice. Interpretation of the results of laboratory analyzes. Clinical trials (efficacy). Information about drugs. Evidence based pharmacy. Clinical audits. Therapeutic drug monitoring (TDM). Individualization of pharmacotherapy. Compliance (adherence). Drug safety, pharmacovigilance. Pharmacoeconomic aspects of rational pharmacotherapy. Communication skills. Specifics of pharmacotherapy in elderly patients, children, patients with renal and hepatic impairment, pregnant women, nursing mothers.Practical classes:Communication skills. Finding reliable information about medicines and treatments. Interpretation and evaluation of the quality of clinical trials. Evaluation of pharmacoeconomic studies in order to design rational pharmacotherapy. Assessment of drug

safety. TDM in practice. Pharmaceutical care examples (case studies) in specific patient populations (in elderly patients, children, patients with renal and hepatic impairment, pregnant women, nursing mothers). Part of the exercise is done in the clinic.Literature: 1. Walker R., Edwards C. (eds.): Clinical Pharmacy and Therapeutics, 2nd ed., Churchill Livingstone, Edinburgh, 2000, 2nd ed.,

School book Zagreb, 2004.2. Walker R., Edwards C. (eds.): Clinical Pharmacy and Therapeutics, 4th ed., Churchill Livingstone, Edinburgh, 2007.Number of active teaching: Other classes:Lectures: 45 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching:lectures, workshops, e-learning, case study, problem analyses, work in policlynic.



PHARMACEUTICAL PRACTICE

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Pharmaceutical PracticeTeacher: PhDSubjects status: compulsorySemester: fifth year, ninghth semesterECTS: 5Requirement: PharmacologySubjects objective: Mastering the basic concepts of pharmaceutical practice at all levels of health care system (primary, secondary, tertiary). Essential drug list, drug list types. The role of public pharmacy in primary health care. Classification of products relevant to the key processes of pharmaceutical practice (rent, sales, consulting). Understanding the basic sources of information about medications. Knowledge of the processes about prescribing medications, dispensing medical products. Refund and pharmacy administration, the process of selling OTC drigs in pharmacies. Knowledge of basic concepts of clinical pharmacy (separate course). Drug safety (monitoring the use of drugs).Subjects outcome:After passing the exam, the student will: know the pharmaceutical health care system, know the types, forms and classifications of drugs and medical devices in a public and hospital pharmacy, will understand the importance and role of certain information and know how to analyze them, will understand the importance of prescriptions and orders in pharmaceutical practice, will understand the importance and need for clinical practice (separate course), will understand the purpose of promoting health in public pharmacies.Subjects content:Lectures Introduction to pharmaceutical health care system, World Health Organization and the concept of essential drugs; national drug list; hospital drugs list. Pharmaceutical practice: public and hospital pharmacies in the health care system; practice activities (planning, procurement, storage, issuance, distribution). Pharmaceutical products: groups, forms, classifications; medical devices and products within health care (preventive, diagnostic, therapeutic and rehabilitative means). Prescription and order - the structure, prescribing medications and medical devices, calculations, reimbursement and administration. Information resources in pharmaceutical science and practice, types of information, sources, levels, information management; special sources of information. Health promotion and disease prevention, basic programs of public pharmacies. Advising patients. Clinical practice - basic terms and concepts to improve treatment and outcomes in a public and hospital pharmacy. Private and public sector.Practical classesCase study analysis - selected work activities in public or hospital pharmacy (examples with lists of medications, procedures, etc.). Simulation of working with prescription, calculations and computations. Simulation of patient counseling. Working with

basic pharmaceutical sources of information (manuals and electronic database). Workshop on the topic of pharmaceutical practice, analysis, discussion. Part of the exercise is done in a pharmacy.Literature: 1. Winfield A. J.: Pharmaceutical Practice, Churchill Livingstone, Edinburg, 3rd ed., 2004.2. Smith M. C., Wertheimer A. I.: Social and Behavioral Аspects of Pharmaceutical Care, Pharmaceutical Press, London,

1996.3. Grujić V., Martinov-Cvejin M., Leković B.: Menadžment u zdravstvu, udžbenik, Medicinski fakultet, Novi Sad, 2007.4. Legetić B. i sar.: Pristupi i metode menedžmenta u zdravstvenim ustanovama (ur.: Jakovljević Đ., Grujić V.), Evropski

centar za mir i razvoj, Univerzitet za mir Ujedinjenih nacija, Naučna knjiga, Beograd, 1998.5. Grujić V., Martinov Cvejin M., Legetić B.: Ekonomika zdravstva, Medicinski fakultet, Novi Sad, 1993.6. Smith F.: Research Methods in Pharmacy Practice, Pharmaceutical Press, London, 2005. 7. Kayne S. B.: Pharmacy Business Management, Pharmaceutical Products Press, London, 2005.8. Remington G.: The Science and Practice of Pharmacy, 21st ed., Lippincott Williams & Wilkins, London, 2005.9. Tasić Lj, Krajnović D, Petrić M, Lakić, D, Tadić I.: Farmaceutska praksa, praktikum, Farmaceutski fakultet, Beograd, 2009.Number of active teaching: Other classes:Lectures: 15 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, panel discusions, workshops, exercises, work in pharmacy


Lectures 5 Exame 50Practical classes 30Colloquiums 10Seminars 5Research Work

Study programes: pharmacyType and level of study: integrated academic studiesECTS: 10Requirement: all the IX semester courses worth 270 ECTS passedThe objective of the research work:Research work enables the student to start preparing the final paper. Understanding and learning the basics of scientific research methodology, independent literature search and critical interpretation of the results. Introduction to ethical and professional conduct of researchers. Training for independent laboratory work. Gaining knowledge about the presentation of research results.Expected outcome:Students will be able to:- find the specialized literature relevant to the given topic of thesis,- make an experimental plan with the help of a mentor,- perform laboratory experiments independently,- choose the unit to be presented based on the results,- process the problem in the light of data from the literature,- write the paper according to world-recognized rules of writing scientific papers.Number of hours: 225Меthods of execution:Individual work with a mentor, work in small groups in labrotory, discussions.Grading (mаximum 100 points):preparation and literature search: 30experimental work in the laboratory: 50results discussion: 20The objectives of the research work:Research work enables the student to start preparing the final paper. Understanding and learning the basics of scientific research methodology, independent literature search and critical interpretation of the results. Introduction to ethical and professional conduct of researchers. Training for independent laboratory work. Gaining knowledge about the presentation of research results.

Graduation PaperStudy programes: pharmacyType and level of study: integrated academic studiesECTS: 5Requirement: all the IX semester courses worth 270 ECTS passedThe objective of the final paper:To enable students to apply basic theoretical, methodological, scientific and technical, professional and applicative knowledge and methods to solve practical problems within the chosen topic of the final paper. In the final work student, studying the available literature, and experimental work in the laboratory, studies the problem, and the complexity of its structure and based on the conclusions of the analysis comes to the possible ways of solving it. Also, the student is taught to write the final paper, presented it in a timely manner and discuss the work with professionals.Expected outcome: A student is qualified, based on the knowledge and skills acquired while studying, to do experimental work in the lab and collect references, write a paper and present it before a competent committee.

General content:The final paper is student's research in which he become familiarized with the methodology of research in all areas relevant to pharmacy. The topic of the work may be experimental or bibliographic. After conducting research, the student prepares the final work in a form that contains the following chapters: Introduction, theoretical part, the experimental part (if the work is done experimentally), Results and Discussion, Conclusions, Bibliography. Taking the final exam consists of an oral presentation of the paper by the student, questions asked by the members of the committee and answered by the student.Number of hours: 75Меthods of execution: During writing the final paper, the mentor provides all the necessary instructions to the student, advises him on which literature to use, assists selecting research methods, analysis and processing of the results, helps him reach correct conclusions, and others. In this final part, the student does additional consultation with the supervisor and, if necessary, with other teachers that deal with the topics of the final paper. If the final work involves experimental work, the mentor introduces the student with the work in the laboratory, they select chemicals, safety measures, handling tools, and the like.Grading (maximum 100 points):The grade of the final paper is a sum of points awarded for:- experimental work (if the work is experimental in character), 30 points- written part, 20 points- presentation of work, 20 points- answers to questions on the topics before the committee, 30 points

Internship

Study programes: pharmacyType and level of study: integrated academic studiesTeacher(s) responsible for organizing professional practice: ECTS: 15Requirement: all the IX semester courses worth 270 ECTS passedThe objective:During the tenth semester the student who has completed all courses required in the ninth semester, should be trained for independent professional work. In the course of practice, students learn to apply and develop the knowledge and skills acquired during his studies, build personal and professional attitude, behavior and responsibility to the profession and service users.Expected outcome:During the practical part the student applies the knowledge and skills acquired in the course of nine semesters of practical and theoretical instruction. Students also acquire and develop new knowledge and skills which include: 1. pharmacotherapeutic aspects 2. aspect of pharmaceutical care 3. pharmaceutical-technological aspects 4. aspects of pharmaceutical regulation and legislationPharmacotherapeutic aspect - Knowledge of the indications, contraindications, interactions, adverse and toxic drug reactions - Dosage regimens and individualized treatment - Rational pharmacotherapy - The efficacy and safety of used drugs - Good clinical practice in clinical trials of drugsAspect of pharmaceutical health care - Health promotion and disease prevention - Application of standards in pharmacy practice - Selection, planning and provision of drugs and medical devices - Drug dispensing and sale of drugs and medical devices - Preparation (and overseeing the preparation) - Giving instructions to patients for proper application of drugs in dosage - Identifying and distinguishing the symptoms of ailments from conditions that require the patient to be refered to a

doctor - Selection and counseling when dispensing drugs without a prescription - Monitoring, notifying and reporting adverse drug reactions - Monitoring and recording drug interactions - Identifying the problems related to the use of drugs and development of pharmaceutical health care plans - Communication with patients / caregivers, physicians - Keeping records of treatment for an individual patient - Patient counseling and compliance of the prescribed therapy - Learning how to get information about drugs and pharmacy practice - Monitoring the use of drugs - Inventory control of drugs and drug records under a special drug control regime, pharmaceutical waste handling and disposal - Quality of service and customer satisfactionPharmaceutical-technological aspects - Pharmaceutical calculations - Preparation of drugs in the pharmacy - Different methods of drug preparation - Manufacture of sterile medicinal products - Monitoring the stability of medicinal preparations - Calculating the price of products - Keeping records of medicinal preparations - Handling of hazardous substances that require precautions - Handling of cytotoxic drugs (potential hazards and precautions) - Proper storage of drugs, active and support substances - Packaging - Preparation of certain cosmetic products in the pharmacyAspect of drug regulation and legislation - Knowledge and application of the Law on Medicines and Medical Devices, the Law on Health Care, the Law on Health Workers, the Law on Health Insurance, the substances used in the illicit manufacture of narcotic drugs and psychoactive substance - Knowledge and application of the above-mentioned laws - Knowledge and application of the Essential drug list and the list of drugs and medical devices are prescribed and dispensed at the expense of health insurance - Knowledge and application of regulations governing the operation of a pharmacy - The application of ethical conduct in the practice, ethical decision making, assessment of professional responsibility.Сontent of professional practice:Student does professional practice within 375 hours in the pharmacy of the public sector and 75 hours in the pharmacy of hospital sector (hereinafter referred to as Option A), or 300 hours in a public pharmacy and 150 hours in the hospital pharmacy sector (hereinafter referred to as option B) depending on the availability of the health care system.Public pharmacies 1. Making magistral and galenic drugs at the pharmacy (120 hours - option A; 90 hours - Option B) 2. Dispensing (225 hours - option A; 180 hours - Option B) 3. Conducting administrative and management processes of work (30 hours)Hospital Pharmacy 1 Planning, purchasing, receiving and storage of drugs and medical devices (15 hours - option A; 45 hours - Option B) 2 Publication and distribution of drugs (15 hours - option A; 30 hours - Option B) 3 Making of drugs (7.5 hours - option A; 15 hours - Option B) 4 Conducting administrative tasks (7.5 hours - option A; 15 hours - Option B) 5 Clinical Pharmacy / Pharmaceutical Health CareNumber of hours: 450Мethods of exection:Student performs the practical part in these institutions under the supervision of a pharmacist with at least 5 years of

experience in pharmaceutical health services.Grading:Student’s participation in professional practice are recognized and after fulfilling the obligations the appropriate certificate is given and the student is required to give it to the responsible teacher appointed by the Academic Council of the Faculty. Confirmation of completed practical classes shall be entered in the student's record and after that he is entitled to taki his final exam provided that the other conditions are fulfilled.

Steroid Compounds, Use and Abuse

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Steroid Compounds, Use and AbuseTeacher: Subjects status: optionalSemester: second year, fourth semesterECTS: 2Requirement: noSubjects objective: Gaining knowledge of chemistry steroid compounds, necessary for exploring and understanding the importance of steroid compounds, especially in the human body. Also knowledge of the structure of steroid compounds, the characteristic chemical reactions that lead to the transformation of the steroid nucleus.Subjects outcome:Overcome the necessary knowledge of chemistry sterodnih hormones and their effect on the metabolism of steroid structure the compounds karakterictičnim reactions, Total and partial synthesis.Subjects content:Lectures The study of the mechanism of action of steroid hormones influence the metabolism. Introduction to the structure of the sex hormones: androgens, estrogens, progestins, properties, isolation, specific reactions. The study of the characteristic reactions to antiandrogenih synthesis and anti-estrogenic compounds. First of all, it is proved that some androgenic hormone responsible for the occurrence of prostate cancer and benign prostatic hyperplasia, and will therefore study the structure of steroidal compounds with antiandrogen activity. Studying the properties of bile acids, basics of their physiological effects. Study of the properties of corticosteroids, cardiac glycosides and aglycones, as well as steroidal alkaloids, with an emphasis on selected chemical reaction of the same. The study of selected synthesis of steroid compounds that showed potential biological activity. Practical classesPreparation dry solvents and reagents for synthesis of selected steroid compounds. Functionalization of A, B, and D-ring steroid nucleus and confirmation of the structure of the obtained products on the basis of spectroscopic data.Literature: 1. Lednicer Daniel: Steroid Chemistry at a Glance, Willey, Chichester, New York, 2011.2. Stefanović Milutin: Steroid Chemistry, University in Belgrade, 1964.3. Penov-Gaši K., Đurendić E., Medić-Mijačević LJ.: Chemistry of androgens, antiandrogens and their applications in

biomedicine, Faculty of Science, Novi Sad, 2001.4. Kuhajda K., Kandrač J., Mikov M.: Bile acids, Faculty of Science, Ortomedics, Novi Sad, 1999.5. Fieser L. F., Fieser M.: Natural products related to phenanthrene, 3th ed., Reinhold Publ. Co., New York, 1952.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, individual work with students, e-learning.



PHARMACEUTICAL PRODUCTS FROM ALGAE AND FUNFIStudy programs: pharmacyType and level of study: integrated academic studiesName of subject: Pharmaceutical Products from Algae and FungiTeacher: Subjects status: optionalSemester: second year, fourth semesterECTS: 2Requirement: noSubjects objective: Introduction with biology, ecology and the basis of prokaryotic and eukaryotic taxonomy of algae, fungi and lichens, to be able to understand their phylogeny, distribution and importance in natural ecosystems.Subjects outcome:The outcome of this course is to understand the essence of phylogenetic relatedness, and in particular the diversity of algae, fungi and lichens, as well as their indicator properties.Subjects content:Lectures General characteristics of algae and their basic stages of the talus. Establishing knowledge prokaryotic and eukaryotic algae cell structure, and a summary of their methods of reproduction, development cycle and ecology. Introduction to Biology Cyanophyta, Rhodophyta, Euglenophyta, Pyrrophyta, Xanthophyta, Chrisophyta, Bacillariophyta, Chlorophyta, Charophyta, Phaeophyta. Characteristics kingdom Mycota and biology Myxomycota Eumycota and the representatives of the subdivisions Mastigomycotina, Zygomycotina, Ascomycotina, Basidiomycotina, Deuteromycotina, as well as the characteristics and biology Lichenes.Practical classesPractical learning from lectures through the introduction of individual genera of algae, fungi and lichen-members of the taxa treated in the theoretical teaching. E-learning, field teaching. Preparations for field work. The choice of equipment and materials depending on the type of research and the type of terrain. Place for the collection of plants, selection of individuals, the manner warehousing plants until maturity in the lab, writing characters that are changing the collected material, the necessary data to the temporary labels. Specific procedures in gathering moss, ferns, woody and herbaceous plants, succulents. Specifics of the determination of the selected groups.Literature: 1. Rankovic, B.: Systematics of fungi, tutorial, Faculty of Science, Kragujevac, 2003.2. Erbakov, A. V., Ma? Orov, S. R. Polevoi Study of fluorine and gerbarizaci rasten, Lomonosov MGU, Bioogičeski? Faculty,

Moscow, 2006.3. Blazencic J. Systematics algae, Scientific Book, Belgrade, in 1988.4. Gajin S. Matavulj M. Gantar M.: Fundamentals of Microbiology, lower plants and fungi, Practicum, Faculty of Sciences,

Novi Sad, in 1987.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, individual work with students, e-learning, field excersise.



Allergic Plants

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Allergic Plants with the Basics of AllergologyTeacher: Subjects status: optional

Semester: third year, fifth semesterECTS: 3Requirement: BotanySubjects objective:Introduction to the representatives of different systematic categories of higher plants challengers hay and / or contact allergies, their biology, ecology and importance of the fauna.Subjects outcome:Independently planning and implementing studies of allergic plants, processing the results, their interpretation and presentation.Subjects content:LecturesThe concept of allergies and the allergy. Contact allergy and plant species that cause them. Morphological and biochemical characteristics of plants that causecontact allergies. Pollen allergy and plant species that cause them. Morphological and micro-morphological characteristics of plants causing pollen allergy. Types of the allergy from groups: Cl. Magnoliopsida: Subcl. Magnoliidae, Subcl. Ranunculidae, Subcl. Hamamelididae, Subcl. Caryophyllidae, Subcl. Dileniidae, Subcl. Rosidae, Subcl. Lamiidae, Subcl. Asteridae. Cl. Monocots: Subcl. Liliidae, Subcl. Commelinidae, Subcl. Arecidae.Practical classesGetting to know the actual representatives of allergic plants from group Cl. Magnoliopsida: Subcl. Magnoliidae, Subcl. Ranunculidae, Subcl. Hamamelididae, Subcl. Caryophyllidae, Subcl. Dileniidae, Subcl. Rosidae, Subcl. Lamiidae, Subcl. Asteridae. Cl. Monocots: Subcl. Liliidae, Subcl. Commelinidae, Subcl. Arecidae.Literature: 1 Igić R., Boza P., G. Anackov, Vuk D. Atlas allergenic plants of Novi Sad, Faculty of Sciences, Novi Sad, 2005.2 Igić R., Vuk D. Systematics of higher plants, practical classes for students of biology and ecology, environmental

protection, Faculty of Sciences, Novi Sad 2000.3 Cvrtila D. allergenic plants, Pharmacia Inc. Yugoslavia, Ljubljana press, Kranj, in 1984.4 Tatic, B., Blečić, V. Systematics and phylogeny of higher plants, textbook, Institute for Textbooks and Teaching

Aids, Belgrade, in 1984.5 Mägdefrau K. Ehrendorfer F.: Systematics, evolution and geobotany, school books, Zagreb, Croatia, in 1978.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, laboratory exercises, e-learning, field exercises.



Colloid Systems in Pharmacy

Study programes: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Colloid Systems in PharmacyTeacher: Subjects status: optionalSemester: third year, fifth semesterECTS: 3Requirement: General ChemistrySubjects objective:The goal is to enhance student’s knowledge in the characteristics and behavior of colloidal systems, the characteristics of natural and synthetic macromolecules and supramolecular structures, surfactants, the states of sols and dispersion systems, in order to gain better understanding of the technology of pharmaceutical preparations. In addition, students get familiar with contemporary scientific achievements in the area of application of colloids in pharmacy

Subjects outcome:Student is familiar with the chemistry of colloidal systems; structure, characteristics and behavior of natural and synthetic macromolecules and supramolecular structures. He/she is accustomed to the methods of separation, purification, identification and characterization of colloids; Student knows fundamental principles of rheology and different techniques of determination of rheological characteristics, as well as contemporary scientific achievements in the area of application of colloids in pharmacy.Subjects content:LecturesClassification of colloidal systems; natural and synthetic macromolecules; Preparation of colloids, surface active agents, structure of surface active agents and their practical importance. Solubilization, factors which influence solubilization, thermodynamics of solubilization. Optical and kinetic characteristics of colloids. Separation of colloids by methods applicable in pharmaceutical practice. Basics of rheology, defining Newtonian and non-Newtonian systems (plastic, pseudoplastic, dilatant, thixotropic).Determination of rheological characteristics of fluids, viscoelasticity. Application of colloidal supramolecular structures for drug delivery (nanomaterials, polymers, liposomes). Nanocomposites. Self-organization of surfactants. Targeting drug delivery. Application of nanomaterials in diagnostics. Practical classesTurbidimetric determination of colloid concentration, separation of colloids, determination of rheological characteristics of colloids.Literature: 1. Milić N. B.: Neorganska kompleksna i klasterna jedinjenja, udžbenik, Prirodno-matematički fakultet, Kragujevac,

1998.2. Leovac V. M., Neorganska hemija II, praktikum, Prirodno-matematički fakultet, Novi Sad, 2005.3. Ribas Gispert Joan: Coordination Chemistry, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Wieena, 2008.4. Filipović I., Lipanović S., Opća i anorganska hemija, Školska knjiga, Zagreb, 1985.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, laboratory exercises, e-learning.



Coordination Compounds in Pharmacy

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Coordination Compounds in PharmacyTeacher: Subjects status: optionalSemester: third year, fifth semesterECTS: 3Requirement: General ChemistrySubjects objective:gaining the current knowledge in the field of chemistry, structure and application of coordination compounds.Subjects outcome:Introducing the special classes of organic ligands and synthetic methods and characterization of their metal complexes.Subjects content:LecturesType of the ligands and coordination compounds. Metal complexes with non and macrocycle ligands (cryptands, dendrimers, etc.). Organometallic compounds (carbonyl, metallocene, etc.). Chemical bond in the coordination compounds. Valente bond theory, theory of ligand field and molecular orbital theory. Reaction mechanisms, synthetic methods (template and nontemplate reactions, reaction of the coordinated ligands, transmetallation and demetallation of

complexes) and characterization methods for the metal complexes. Application of metal complexes in medicine and in catalysis. Practical classesAnalysis of potential coordination number and oxidation state of the elements. Analysis of dia and paramagnetic properties of some elements. Synthesis of eight transition metal complexes, one complex containing metal from IIa group as well as one complex containing f metal, characterization. Synthesis and characterization of geometrical and optical isomers. Analysis of the application of selected examples of coordination compoundsLiterature: 1. Milić N. B.: Neorganska kompleksna i klasterna jedinjenja, udžbenik, Prirodno-matematički fakultet, Kragujevac,

1998.2. Leovac V. M., Neorganska hemija II, praktikum, Prirodno-matematički fakultet, Novi Sad, 2005.3. Ribas Gispert Joan: Coordination Chemistry, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Wieena, 2008.4. Filipović I., Lipanović S., Opća i anorganska hemija, Školska knjiga, Zagreb, 1985.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, laboratory exercises, e-learning.



Heatlh and Pharmacy Management

Study programes: pharmacy, pharmacy Type and level of study: integrated academic studiesName of subject: Health and Pharmacy ManagementTeacher: Subjects status: optionalSemester: third year, fifth semesterECTS: 3Requirement: noSubjects objective:The objective of this course is to introduce students to: the general and fundamental principles of modern business / management and organizational development needs of health care and pharmacy; to master the management of the health care system and the organization of the pharmaceutical sector (from production to patient); management skills of pharmaceutical market goods, laboratory (biochemical), health care and pharmaceutical servicesSubjects outcome:After passing the exam, the student will be able to: understand the specifics of the health care and pharmaceutical industry, to master the fundamental methods of management in medicine and pharmaceutical market; basic skills of organization / management in the health care and pharmacy knowing the basic standars of labor; to master the supply processes in the chain manufacturer-wholesaler-pharmacy-health care system; apply management skills in a competitive business of medical labrotories and pharmacies.Subjects content:LecturesGeneral concepts of management in health care and pharmacy. Health care policy, pharmacopolitics. Mission, vision and leadership in health care and pharmaceuticals, benchmarking, outsourcing and globalization in the pharmaceutical business. QMS development and human resources in biochemical laboratory, pharmacy. Basic theory of organization, management of the quality system. Organizational changes. Management of the health care system. National medication policy; logistics and supply of public health care system. Pharmaceutical market and business brand and generic drugs; drug marketing concept and social values, methods and strategies of pharmaceutical marketing. Supply chain, business standards of

good pharmaceutical practice and good laboratory practice. Management of biochemical laboratory, public pharmacies. Managing projects in health promotion; information technologies used to promote health and medication, competitiveness between public and private sectors.Practical classesDiscussions on the topics of processes and functions of management: industry, biochemical laboratory, pharmacy. A case study. Marketing strategy of biochemical laboratory, strategies of the selected drugs in selected markets. Good laboratory and pharmaceutical practice, improvement. The organization and structure of segments of laboratory and pharmaceutical business: medical, biochemical laboratories, microbiological laboratories, pharmacies, wholesalers, manufacturing. Quality standards in practice (ISO 9000, 14000). Cost analysis and rational use of medications.Literature: 1. Tasić Lj.: Farmaceutski menadžement i marketing, udžbenik, Nauka, Beograd, 2002.2. Grujić V., Martinov-Cvejin M., Leković B.: Menadžment u zdravstvu, udžbenik, Medicinski fakultet, Novi Sad,

2007.3. Legetić B. i sar.: Pristupi i metode menedžmenta u zdravstvenim ustanovama (ur.: Jakovljević Đ., Grujić V.),

Evropski centar za mir i razvoj, Univerzitet za mir Ujedinjenih nacija, Naučna knjiga, Beograd, 1998.4. Grujić V., Martinov Cvejin M., Legetić B.: Ekonomika zdravstva, Medicinski fakultet, Novi Sad, 1993.5. Leković B.: Principi menadžmenta: Ekonomski fakultet, udžbenik, Subotica, 2007.6. Kotler Ph.: Upravljanje marketingom, Naklada, Zagreb, 2004.7. National Drug Policy WHO (World Health Organization) 2002, Esential drug list 13th, Organization of United

Nations, New York, 2005.8. Nikolin M. i sar.: Galerija farmaceutskih veština, Placebo, Beograd, 2005.9. Smith M. C., Wertheimer A. I.: Social and Behavioural Aspects of Pharmaceutical Care, Pharmaceutical Products

Press, New York, 1996.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, exercises, case study, e-learning.



ETHICS IN PRE-CLINICAL AND CLINICAL RESEARCH

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Ethics in Pre-clinical and Clinical ResearchTeacher: Subjects status: optionalSemester: third year, sixth semesterECTS: 3Requirement: noSubjects objective:Mastering the principles of ethics in pre-clinical and clinical trials; understanding the practical importance, knowledge of the difference between ethical and legal issues, development of critical thinking in the process of ethical analysis, understanding the necessity of pre-clinical and clinical studies.Subjects outcome:After passing the exam, the student will be able to: think critically about ethical dilemmas related to pre-clinical and clinical research, know the difference between legal and ethical issues, and be able to apply ethical principles and legal provisions governing the ethical issues and standards related to pre-clinical and clinical research.Subjects content: Lectures

Ethics, pre-clinical research, clinical research. Nüremberg Code. Helsinki declaration, consent to research. Ethical analysis of case studies, moral values, wrong judgment. Errors in the research, moral and criminal responsibility. Ethical judgement in respecting moral values and rights of patients. Failure to comply with the codified principles. Ethics Committee. Biomedical research in developing countries. Storage of confidential information. European and international regulations. Legislation in Serbia. Corruption and misuse of pre-clinical and clinical studies.Practical classes Analysis and discussion of case studies (critical assessment of information). Problem-based learning (solving problems with the adequate explanation of the ethical concept and legal framework). Discussions panel. Discussion based on the set of ethical issues. Storage of confidential information.Literature:1. Marić J.: Etika, udžbenik, Medicinski fakultet, Birograf, Beograd, 2007.2. Leštarević M., Šuvaković U.: Medicina i društvo, Kobdom, Beograd, 2007.3. Coleman H. Carl, Menikoff A. Jerry, Goldner A. Jesse, Dubler N. Nansy: The Ethics and Regulation of Research with

Human Subjects, Lexisnexis, Dayton, Ohio, 2003.4. Beachamp T. L., Childress J. F.: Principles of Biomedical Ethics, 5thed., Oxford University Press, New York, 2001.5. Mazur J. Dennis: Evaluating the Science and Ethics of Research on Humans, The Johns Hopkins University Press,

Baltimore, Maryland, 2007.6. Aktuelni zakoni i podzakonska akta Republike Srbije iz oblasti zdravstva.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, panel discusions, case study



PACKING MATERIALS OF PHARMACEUTICAL PRODUCTS

Study programes: pharmacyType and level of study: integrated academic studiesName of subject: Packing Materials of Pharmaceutical Products Teacher: Subjects status: optionalSemester: third year, sixth semesterECTS: 3Requirement: Prarmaceutical Technology ISubjects objective:Introducing students of specialist academic studies to the packaging materials used in pharmaceutical technology. Subjects outcome:Knowing the types of packaging material, acquaintance with the basic requirements and problems with certain packaging materials in practice.Subjects content:LecturesClassification of packaging materials in pharmaceutical technology. Basic requirements. Raw materials. Physico-chemical properties. Selection of optimal materials for packaging of selected pharmaceuticals. The importance of packaging choices to stability pharmacologically active substances. Packaging and protection of solid, liquid and semi-solid medicinal preparations. Sterilization of medical products and supplies dry heat, steam and bacterial filtration. Preparation of medicinal products under aseptic conditions. Impact of packaging on the shelf life of pharmaceutical products. Production of packaging material make. Well-known manufacturers in Serbia and the region.Practical classesSelection of optimal materials for packaging of selected pharmaceuticals. Impact of packaging on the shelf life of

pharmaceutical products. Packaging and protection of selected mixture of medicinal preparations. Packaging and protection of selected liquid medicinal preparations. Packaging and protection of semi solid medicinal preparations. Sterilization of medical products and kits with dry heat. Sterilization of medical products and supplies steam. Sterilization of medical products bacteriological filtration. Preparation of medicinal products under aseptic conditions. E-learning: an analysis of well-known manufacturers of packaging for pharmaceutical products in Serbia and the region. Field trip lessons.Literature: 1. Coulson J. M., Richardson J. F., Backhurst J. R., Harker J. H.: Chemical Engineering, Butterworth-Heinemann,

Oxford, 2003.2. Geankoplis C. J.: Transport Processes and Unit Operation, 4th ed., Prentice Hall, Englewood, New Jersey, New

Jersey, 2003.3. Connors K. A.: Drug Stability, Principles and Practices, 21st ed., Lippincott Williams & Wilkins, London, 2005.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, exercises, case study, e-learning.



GREEN CHEMISTRY IN PHARMACEUTICAL INDUSTRY

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Green chemistry in pharmeceutical industry Teacher:Subjects status: optionalSemester: third year, sixth semesterECTS: 3Requirement: General Chemistry, Organic Chemistry ISubjects objective:The aim of this subject is to introduce the students to one of the latest and the most popular analytical application in environmental protection.Subjects outcome:Students will be introduced to aspects of Green chemistry as a preventive science in environmental protection on a molecular level, its main principles and practical application of Green chemistry.Subjects content:LecturesRisks in chemical industry. Effects of harmful compounds on living creatures. Nontoxic reagents and solvents (ionic liquids, biocatalysts, water, supercritical carbon dioxide); Identification of harmful and hazardous substances; benign precursors, synthesis of ligands for selective extraction of metal ions and radioisotopes, a new approach to nuclear and biodegradable materials. Renewable sources in chemical synthesis. New analytical techniques and methods in Green chemistry. Alternative sources of energy, fuel cells.Practical classesSolventless Reactions: The Aldol Reaction. Liquid CO2: Extraction of D-limonene from Orange Rind. Benzoin Condensation Using Thiamine As A catalyst. Rapid And Convenient Synthesis Of The 1,4-Dihydropyridine Privileged Structure. Microwave Assisted Dield-Alder Reaction of Anthracene and Maleic Anhydride. Hydrolysis of a Nitrile. Use of Polyethylene Glycol in the Diels-Alder Reaction. Biodiesel Synthesis and Evaluation of Organic Chemistry Experiments. Simulation of reactions and Green chemistry’s processes in lab conditions. Analysis of practical cases. E-learning.

Literature: 1. Lancater М.: Green Chemistry, 2nd ed., Royal Society of Chemistry, London, 2010.2. Allen T. D., Schonnard D. R.): Green Engeneering, Environmentally Conscious Design of Chemical Proccesses),

Prentice Hall PTR, New York, 2008.3. Roesky Herbert W., Kennepohl Dietmar, Lehn Jean-Marie (eds.): Experiments in Green and Sustainable Chem -

istry, Willey, New York, 2009.4. Dunn Peter, Wells Andrew, Williams Michael T. (eds.): Green Chemistry in the Pharmaceutical Industry, Willey,

New York, 2010.5. Doxsee Kenneth, Hutchison James: Green Organic Chemistry: Strategies, Tools, and Laboratory Experiments,

Brooks Cole, Belmont, 2004. 6. Lampert R. i sar.: Next Generation Environmental Technologies, RAND, San Diego, California, 2003.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, laboratory exercises, work in groups, Practical classes., field excersise



QUALITY CONTROL IN PHARMACY

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Quality Control in Pharmacy Teacher:Subjects status: optionalSemester: third year, sixth semesterECTS: 3Requirement: noSubjects objective:The aim of the course is: exploring and providing views of students on the activities in the area of management. Allow them to solve specific problems in the manufacturing practices in the pharmaceutical industry. Mastering the essential knowledge about ways of ensuring the quality of the production process in the pharmaceutical industry, or the entire business, considering the quality is dominant feature of modern pharmaceutical industrial production today. Exploring ways of formulating, implementing and innovating system of quality assurance in the pharmaceutical industry.Subjects outcome:After passing the course, student will have basic knowledge of management systems that allow solving con-crete problems in manufacturing practices in the pharmaceutical industry. He will have necessary knowl-edge about ways of ensuring the quality of the production process in the pharmaceutical industry, or the en-tire business, knows the ways of formulating, implementing and innovating systems for quality assurance in the pharmaceutical industry and knows the basic regulations related to quality assurance in Serbia and abroad.Subjects content:LecturesFundamentals of quality: the concept of quality; defining the concept of quality in the pharmaceutical industry. Characteristics of quality. Quality Assurance: Quality Systems (basically, parameters, environment and normative regulation of the quality system). Systems for Quality Assurance (GMP, HACCP, ISO systems, TQM); relationships between the quality systems. Validation of technological procedures and equipment. Logistics: Basically, the concept, the place and role, organization and logistics. Logistics of the production process. Industrial property: Basically, the concept and types of industrial property. The system of industrial

property: parameters and normative regulation of industrial property. Regulations on industrial property in the country, the regulations in Serbia, international conventions.Practical classesCase study analysis. Discussion. Modeling of the quality control system of selected examples of industrial and laboratory (quality control) process pharmaceutical industry. Modeling of the quality control system of selected examples of production processes. Validation of technological procedures and equipment. Case study and solve the original problem in relation to regulations on industrial property in the country and abroad. Analysis of the implementation of HACCP in Serbia. Analysis of the implementation of ISO system in Serbia. Standards in Serbia and abroad.Literature: 1. Kuhre Lee W.: ISO 14000 Certification: environmental management systems, Prentice-Hall Inc., Harlow, 1995. 2. Пешаљевић M.: Инжењерске комуникације и логистика, уџбеник, Факултет техничких наука, Нови Сад, 1995.3. Warholak Terri L., Nau David P.: Quality and Safety in Pharmacy Practice, McGraw-Hill Professional, New York, 2010.4. Baird Rosamund M., Hodges Norman A., Denyer Stephen P.: Handbook of Microbiological Quality Control in

Pharmaceuticals and Medical Devices (Pharmaceutical Science Series), CRC Press, New York, 2000.5. Konieczka Piotr, Namiesnik Jacek: Quality Assurance and Quality Control in the Analytical Chemical Laboratory: A Practical

Approach (Analytical Chemistry), CRC Press, New York, 2009.6. Cascio J., Woodside G., Mitchell P.: ISO 14000 Guide: The New International Environmental Manage-

ment Standards, McGraw Hill, Inc., New York, 1996.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, laboratory exercises, practical classes, solving problems, e-learning



STEREOCHEMISTRY OF ORGANIC COMPOUNDS

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Stereochemistry of Organic Compounds Teacher:Subjects status: optionalSemester: fourth year, seventh semesterECTS: 4Requirement: Organic Chemistry IISubjects objective:The objective of the course is acquiring knowledge about stereochemical qualities of molecules; understanding of stereochemical qualities of organic reactions; understanding of stereochemical qualities of monosaccharides.Subjects outcome:After passed exam, student is enabled for: understanding and recognizing of stereochemical qualities of or-ganic compounds and chemical transformations.Subjects content:LecturesStereochemistry, work with models. Stereoisomerism, simmetry elements, chirality, nomenclature, enantiomers, optical activity, configuration, compounds with more chiral C-atoms, preparation and resolution of racemates, racemic forms, conformation of acyclic compounds, stereochemistry of cyclic compounds, conformations of unsubstituted and substituted six-membered rings, structure and chirality of allenes, spirans and biphenyls, stereoselective and stereospecific reactions, asymmetric synthesis, prochiral compounds, Cram's Rule.Practical ClassesTheoretical practice in stereochemistry.

Literature: 1. Mihailović M.: Osnovi teorijske organske hemije i stereohemije, udžbenik, Građevinska knjiga, Beograd, 1975.2. Eliel Ernest Ludwig: Basic Organic Stereochemistry, 1st ed., Wiley, New York, 2001.3. Pine H. Stanley, Hendrickson B.James, Cram J. Donald, Hammond S. George: Organska hemija, Školska knjiga, Zagreb, 1984.4. Vollhardt K. P., Schore N. E., Organska hemija, 2. izd., Hajdigraf, Beograd, 1996.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, group exercises, work with models


Lectures 5 Exame 50Practical classes 20Colloquiums 25Seminars 0HERBAL EXTRACTS IN COSMETICS INDUSTRY

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Herbal Extracts in Cosmetics IndustryTeacher:Subjects status: optionalSemester: fourth year, seventh semesterECTS: 4Requirement: Pharmacognosy II, CosmetologySubjects objective:The aim of this course is to introduce students to modern methods used in the pharmaceutical industry for the production of plant extracts.Subjects outcome:Students are closely acquainted with the problems of plant extracts and their processes of obtaining in the pharmaceu-tical industry, the problems in practice and current trends.Subjects content:LecturesTypes of plant extracts categorization. Production of plant materials. Quality parameters. The choice of method of extraction. Standardization. Standardization of herbal extracts. Declarations. The active principles of herbal extracts: a different class of polyphenols, phenolic heteroside, coumarin, essential oils, terpenes, saponins. Quality control. Purification. Application. Practical classes Selection of methods for the extraction of selected herbal preparations. Working with essential oils. Purification. Analysis of the use of plant extracts in cosmetic products in the market.Literature: 1. Mazić Senka: Kozmetologija, savremene kozmetičke sirovine, udžbenik, Viša medicinska škola, Beograd, 20012. Blumenthal M., Busse W. R., Goldberg A., Gruenwald J., Hall T., Riggins C. W., Rister R. S.: The Complete German

Commission E Monographs, American Botanical Council, Austin, 1998. 3. Blumenthal M., Goldberg A., Brinckmann J.: Herbal Medicine, Expanded Commission, American Botanical Council, Austin,

2000. 4. Schulz V., Hänsel R., Tyler V. E.: Rational Phytotherapy, Springer, Berlin, 2001. 5. Blumenthal M., Hall T., Goldberg A., Kunz T., Dinda, K.: The ABC Clinical Guide to Herbs, American Botanical Council,

Austin, 2003. 6. Dingermann T., Loew D.: Phytopharmakologie, Experimentelle und klinische Pharmakologie pflanzlicher Arzneimittel,

Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 2003.7. Cosmetics & Toiletries, časopis, Allured bisiness media, Carol Stream, Illinois. Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:

Methods of teaching: interactive lectures, laboratory exercises, work in groups, practical classes.



PHARMACOLOGY IN GYNECOLOGY AND OBSTETRICS

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Pharmacology in Gynecology and ObsetricsTeacher:Subjects status: optionalSemester: fourth year, seventh semesterECTS: 4Requirement: PharmacologySubjects objective:Theoretical knowledge regarding the principles of prenatal diagnosis, pharmacotherapy in gynecology and obstetrics. Laboratory methods of prenatal diagnosis at the level of genetic and chromosomal disorders. The student should acquire knowledge about the biology of serum markers, screening characteristics of biochemical markers in the first and second trimester and integrated screening, as well as the factors that influence the results of determining serum markersSubjects outcome:Knowledge of the concepts related to pharmacotherapy in gynecology and obstetrics. After completing the course, stu-dents will understand what is MoM and what is its distribution, they will know how to calculate the degree of detec-tion of fetal abnormalities and the degree of false-positive results, assess the value of screening and apply software for risk calculationSubjects content:LecturesPrenatal screening for Down's syndrome, neural tube defects and trisomy 18. Markers for the first trimester: plasma protein A linked to pregnancy (PAPP-A) and free β-human chorions gonadotrophin (free β-hCG), nuchal translucency. Markers for second trimester: phetoprotein (AFP), unconjugated estriol (uE3), inhibin-A, free β-human chorions gonadotropin (free β-hCG). Integrated screening. Measurement of serum markers. Calculating the risk level of detection of fetal disorders and the degree of false results. Determination of basic biochemical parameters in pregnancy. Changes in serum protein, polypeptide and steroid hormones in pregnancy. Calculation of risk for particular diseases and birth defects. Analysis of amniotic fluid. Assessment of lung maturity in the fetus. Practical classesCalculation of MoM values of risk. Result interpretation. Analysis and discussion of the results from practice. E-learningLiterature: 1. Burtis C. A., Ashwood E. R., Bruns D. E.: Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 4 th ed.,

Elsevier Saunders, Philadelphia, 2006.2. Nicolaides K. H., Sebire N. J., Snijders R. J. M.: 11-14 Week Scan: The Diagnosis Of Fetal Abnormalities, Pearl

River, New York, 1999.3. Kurjak A. i sar.: Prenatalna dijagnostika i terapija, Tonimir, Varaždinske Toplice, 2000.4. Schaefer Christof, Peters Paul, Miller Richard K.: Drugs During Pregnancy and Lactation, Treatment options and

risk assessment, 2nd ed., Elsevier Academic Press, Waltham, Massachusetts, 2007.5. Williams: Obstetrics, 23rd ed., F. Gary Cunningham, New York, 2002.6. Rang H. P., Dale M. M., Ritter J. M., Moore P. K.: Farmakologija, udžbenik, V izd., Data Status, Beograd, 2004.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching:

interactive lectures, laboratory exerciseswork in groups, practical classes., field excerciseGrading (maximum 100 points)

Pre-Exame commitments Points Final Exame PointsLectures 5 Exame 70Practical classes 10Colloquiums 15Seminars 0

REPRODUCTIVE ENDOCRINOLOGY

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Reproductive EndocrinologyTeacher: Subjects status: optionalSemester: fourth year, seventh semesterECTS: 4Requirement: EndocrinologySubjects objective:The objective of this course is to provide students with: gaining knowledge in the application of laboratory methods in the diagnosis of functional disorders of female reproductive system.Subjects outcome:After passing the exam, the student is able to: master the principles of the most important analysis applied in the laboratory diagnosis of disorders in female reproductive system and interpret obtained laboratory resultsSubjects content: Lectures The role of the hypothalamus in the control of reproduction. Gonadotrope pituitary cells. Prolactin and reproduction. Functional organization of the testis. Hormonal regulation of spermatogenesis. Functional organization of the ovary. Control and disorder of menstrual cycles. Puberty and the maturation of the hypothalamic-pituitary-gonadal axis. Fertilization, implantation and formation of the placenta. Endocrinology of pregnancy. Parturition, lactation and maternal behavior. Menopause and aging. Endocrinology of infertility in women and men. Assisted reproduction. Effects of stress on reproduction.Practical classesMethods for determining gonadotropin-release, follicle-stimulating hormone. Methods for determining estrogen and progesterone. Determining estrogen and progesterone receptors.Literature: 1. Johnson M. H.: Essential Reproduction, Blackwell Publishing, New York, 2007.2. Straus J. F., Barbieri R.L.: Reproductive Endocrinology, Elsevier Saunders, Philadelphia, 2004.3. Stojanov Marina: Laboratorijska endokrinologija, Excelsior, Beograd, 2004.4. Stojilković Stanko i dr.: The Encyclopedia of Hormones Henry H. L., Norman A. W. (еds.), Academic Press, New York,

2003.5. Greenspan Francis S., Gardner David G.: Basic and Clinical Endocrinology, 7 th ed., McGraw-Hill Company, Columbus,

Ohio, 2004.6. Burtis Carl A., Ashwood Edward R., Bruns David E.: Tietz Textbook of Clinical Chemistry and Molecular Diagnosis, W. B.

Saunders Company, 2005.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, practical exercises, laboratory work.



PHARMACY IN DENTISTRY

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Pharmacy in DentistryTeacher:Subjects status: optionalSemester: fourth year, eighth semesterECTS: 4Requirement: noSubjects objective:The objective of this course is to provide students with knowledge of pharmaceuticals, medical devices and medical aparatus which are used in the dental office. The aim of the course is also to familiarize students with the most common causes of mouth diseases, as well as pharmaceuticals used in prevention of diseases.Subjects outcome:After passing the exam, the student is able to: identify the causes of mouth diseases; determine appropriate antibiotic therapy; knows which pharmaceuticals can be used in the prevention of oral diseases; knows which pharmaceuticals and medical devices and medical equipment is used in the dental office, and knows how to present them adequately.Subjects content:LecturesGeneral characteristics of the oral cavity. The general characteristics of microorganisms of the oral cavity. Principles of antibiotic therapy in dentistry (penicillins, cephalosporins, eritomicin, aminoglycosides, tetracyclines, lincomycin, clindamycin, vancomycin, metronidazole, nystatin). Antibiotics in endodontic therapy, treatment of patients with periodontal disease, treatment of dentogeih infections, children's dentistry. Prophylactic use of antibiotics. Allergic and other sensitization reactions. Immune reactions. Non-immunological reactions to antibiotics. Application of other pharmaceutical products in the dental practice. Fundamentals of prosthetics and products used in prosthetics. Surgical intervention in dentistry. Care and gum disease prevention. Tongue care. Medical equipment, tools and appliances used in dental surgery. The application of lasers in dentistry. Types and characteristics of toothpaste and toothbrush. Factors affecting the development of gum disease. The role of food in dental diseases. Specifics of treatment and pharmaceutical devices and equipment used in characteristical groups of patients (children, pregnant women, the elderly, persons simultaneously suffering from other diseases, HIV-infected patients). The role of pharmacists in preventing dental disease.Practical classesCase study analysis. Case simulation. Computer simulations. Visit to the dental office. Critical comparative analysis of toothpaste on the Serbian market. Critical comparative analysis of the toothbrush on the Serbian market. The role of pharmacists in preventing dental disease. Part of the exercises is done in the dental laboratoryLiterature: 1. Leković Vojislav, Lekić Predrag, Petrović Vlastimir: Antibiotici u stomatološkoj praksi, Naučna knjiga, Beograd,

1992.2. Janković S.: Farmakologija i toksikologija, udžbenik, Medicinski fakultet, Kragujevac, 2007.3. Varagić V., Milošević M.: Farmakologija, Medicinska knjiga, Beograd-Zagreb, Beograd 1984.4. Stanojević Zorica, Bukumirić Zoran, Bulajić Sonja: Farmakografija za studente medicine, Alfagraf, Petrovaradin,

Kosovska Mitrovica, 2007.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: lectures, exercises, work in groups, practical classes, excercise in dentistry lab



INFORMATION SYSTEMS IN PHARMACY

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Information Systems in PharmacyTeacher: Subjects status: optionalSemester: fourth year, eighth semesterECTS: 4Requirement: noSubjects objective:The objective of this course is to provide students with the basic knowledge in the area of application of computer science in pharmaceutical science, introduction to software tools for word processing and learning computer programs for spreadsheet.Subjects outcome:After passing the exam, the student is qualified to apply the knowledge of computer hardware, peripheral units, software tools, multimedia and internet applications in real situations in the pharmaceutical business, or to enhance the existing pharmaceutical business with the acquired knowledge. Also, the use of the program for calculating and processing are important for the management of the pharmacist in daily life, speaking of the pharmacist as an individual or someone who represents pharmaceutical company.Сontent of the course: Theoretical classes Basic terms and features of the computer. Organization of a computer. The binary system, the processor, the primary computer memory, RAM, ROM, secondary magnetic memory, secondary optical storage. Peripherals. Software, operating systems, algorithms, word processing, spreadsheets data, scientific calculations and visualizations, simulations and databases. Multimedia. Computer network, communications software. Internet websites, internet access, internet protocols, HTML, World Wide Web, the Internet services. Windows. Word. Excell. Power-point. The specific software used in pharmacy practice.Practical classesInternet. HTML. Windows. Word. Excell. Power-point. The specific software used in pharmay practice.Literature:1. Tasić M., Ćirić M.: Osnovi informatike, udžbenik, Prirodno-matematički fakultet, Niš, 2002. 2. Pasewark/Pasewark, Biheller Bunin Rachel, Evans Jessica, Pinard Katherine T., Romer Robin M.: Microsoft Office 2007:

Introductory Course, Course Technology, Boston, 2007.3. Bunzel Tom: Microsoft Office 2010 kao od šale, CET, Beograd, 2010.4. Softver za rad u apoteci.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, practical exercises, practical work on computer.



EcotoxicologyStudy programs: pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: EcotoxicologyTeacher: Subjects status: optionalSemester: fourth year, seventh semesterECTS: 4Requirement: ToxicologySubjects objective:

The aim of this course is introduction, acquisition, comprehension, application, analysis and evaluation of knowledge and skills in the field of ecotoxicology, especially in relation to the current problems of pollution of urban and rural areas; specific effects on children, women, old people.Subjects outcome:Upon completion of the course, students will be able to: critically think and deal with health problems related to the occurrence of environmental pollution.Subjects content:Lectures The basic concept of ecotoxicology as a science. The main pollutants in the environment, their distribution and the change in the air, water and land. Urban and rural pollution. Response of individuals, populations, communities and ecosystems to contaminants. Indicators of the impact of pollution on human health. Toxicity tests, biological monitoring, biomarkers of environmental hazards. Basis of risk assessment. Management of toxic substances and legislation.Practical ClassesDiscussions, seminars, analysis of the situation in Serbia and abroad, workshops.Literature: 1. Walker C. H. (ed.), Hopkin S. P.: Principles of Ecotoxicology, 2nd ed., CRC Press, Boca Roton, 2001.2. Newman M. C., Unger M. A.: Fundamentals of Ecotoxicology, 2nd ed., CRC Press LLC, Boca Roton, 2003.3. Mokranjac St. M.: Toksikološka hemija, udžbenik, Grafopan, Beograd, 2001.4. Đurić B. D., Petrović J. Lj.: Zagađenje životne sredine i zdravlje čoveka, ur.: Ražnatović T. M., Velarta, Beograd, 1996.5. Jokanović M.: Toksikologija, ur.: Gavrilović M., udžbenik, Elit Medica, Beograd, 2001.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, laboratory exercises, e-learning.


Lectures 5 Exame 60Practical Classes 10Colloquiums 20Seminars 5

INTEGRATIVE MEDICINE

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Integrative MedicineTeacher:Subjects status: optionalSemester: fifth year, eighth semesterECTS: 4Requirement: noSubjects objective:The objective of the course is to provide students with basic information about the different concepts and approaches to therapy; to enable students to acquire knowledge about the most important techniques that are covered by the term complementary medicine; to offer basic information about particular techniques of complementary medicine; to provide the prerequisites for understanding the integrative approach to therapy.Subjects outcome:After passing the exam, the student will be capable of thinking logically about different approaches to therapy and treatment; access to treatment studied by complementary medicine; basic characteristics of particular methods; current situation of different forms of complementary medicine in Serbia and worldwide trends. Also, the student will be able to interpret existing legislation in Serbia related to the branches of complementary medicine.Subjects content:LecturesShowing various concepts defining conventional, complementary and alternative therapies, holistic and integrative approach to treatment. The concepts and techniques that are now classified as non-conventional treatment techniques, therapeutic in use. Naturopathy, homeopathy, acupuncture, acupressure, aromatherapy, mud therapy, crystal therapy, smell, sound therapy. Access

to information about current and new forms of alternative therapy. The relationship between traditional medicine and alternative therapies. Basic assumptions of traditional Chinese medicine, kampo, ayurveda, traditional African medicine. Traditional healing systems in the Balkan region. Safety in the selection or the use of complementary medicine methods.Practical classesVisits to the centers for alternative therapy. Introduction to real cases. Discussion. A case study. Website.Literature: 1. Popović M.: Homeopatija, izd. Popović M., Beograd, 2002.2. Škokljev A.: Akupunkturologija, Naučna knjiga, Beograd, 1989.3. Jovanović-Ignjatić Zlata: Kvantno hologramska medicina kroz prizmu akupunkturnih i mikrotalasno rezonantnih (samo)

regulatornih mehanizama, Quanttes, Beograd, 2010.4. Omura Yoshiaki: Practice of the Bi-Digital O-Ring Test, Ido No Nippon, Tokyo 1986.5. Robson Terry: An introduction to Complementary Medicine, Allen &Unwin, Sydney, 2003.6. Micozzi S. M.: Fundamentals of Complementary and Alternative Medicine, 4thed., Saunders, Philadelphia, 2010.7. Kotsirilos Vicki, Vitetta Luis, Sali Avni: A Guide to Evidence-based Integrative and Complementary Medicine, 1 st ed.,

Churchill Livingstone, Edinburg, 2011.8. Hecker Hans-Ulrich, Steveling Angelika, Peuker Elmar, Kastner Joerg: Color Atlas of Acupuncture: Body Points - Ear

Points - Trigger Points (Complementary Medicine), Thieme, 2008.9. Sutton Amy L: Complementary and Alternative Medicine Sourcebook, Omnigraphics, Detroit, 2010.10. Zhanwen Liu, Liang Liu: Essentials of Chinese Medicine, Springer, London, New York, 2009.11. Kligler Benjamin, Lee Roberta: Integrative Medicine principles for practice, Program in Integrative Medicine, University of

Arizona. McGraw-Hill Companies, NY, Chicago, London, Madrid, Milan, Sydney, Toronto, Singapur, New Delhi, 2004.Number of active teaching: Other classes:Lectures: 15 Exercises: 15 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, work in groups, panel discusions, case study, field trip



Scientific ResearchStudy programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Scientific ResearchTeacher: Subjects status: optionalSemester: fifthyear, ninghth semesterECTS: 4Requirement: noSubjects objective: Training of students for scientific research.Subjects outcome:Acquiring necessary knowledge that will enable students for scientific research.Subjects content:Lectures Importance of scientific research. Difference between scientific and professional research. Stages of scientific research. Choosing a topic. Research of literature. Experiment. Structure and writing of scientific research paper. Types of scientific research. Evaluation of scientific research. Practical Classes Techniques of collecting, sorting and analyzing literature. Research of selected electronic databases. Analysis of research results. Graphic presentation of data. Writing of scientific research paper. Citing of literature.Literature: 1. Milankov V., Jakšić P.: Metodologija naučno-istraživačkog rada u biološkim disciplinama, udžbenik, Prirodno-matematički

fakultet, Novi Sad, 2006.2. Šomođi Š., Novković N., Kralјević-Balalić Marija, Kajari Karolina: Uvod u naučni rad, udžbenik, Polјoprivredni fakultet,

Novi Sad, 2004.3. Ebel H. F., Bliefert C., Russey W. E.: The art of scientific writing, Wiley-VCH, Verlag GmbH & Co. KgaA, Weinheim,

2004.4. Konvencionalne i elektronske baze podataka.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: lectures, exercises, discussions, e-learning, part of the exercises are performed in laboratories.



CLINICal ResearchStudy programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Clinical ResearchTeacher:

Subjects status: optionalSemester: fifth year, ninghth semesterECTS: 4Requirement: noSubjects objective: The objective of this course is that students get theoretical and practical knowledge about the qualitative and quantitative design and mixed methods and techniques of clinical research specifically related to clinical research in pharmacy, pharmaceutical clinical practice and clinical biochemical practice.Subjects outcome:After completing the course, students will have a basic theoretical knowledge and practical experience of qualitative, quantitative and mixed designs, methods and techniques of clinical research and the design of clinical trials of pharmaceuticals products , pharmaceutical products and diagnostic methods and techniques. After completing the course and practical training during the course, each student will have the elaborated plan of the research according to his preferences.Subjects content:Lectures Introduction to clinical research. Planning and design of clinical research in pharmacy and pharmaceutical sciences (research questions, literature search, variables and their measurement, human subjects in clinical studies, the committee for the protection of human subjects in clinical research, human subject for participation in clinical trials). Qualitative clinical researches (studies of individual clinical cases, a series of clinical cases, interview, preparation of questionnaires, field research, focus groups). Examples of qualitative clinical research in clinical pharmacology (analysis and discussion). Quantitative clinical research (descriptive quantitative clinical research, clinical correlation studies, quasi-experimental research, experimental clinical research). Examples of quantitative clinical research in clinical pharmacology (analysis and discussion). Mixed methods in clinical research (strategy Mixed methods research design selection of mixed methods, triangulation, incorporating design, survey design, design explanations). Examples of mixed methods in clinical research (analysis and discussion). Database development, sample size, quality control, data acquisition, control studies. Small clinical experiments (examples of a small experiment in pharmaceutical clinical research, analysis and discussion). Clinical trials of potential drug substances, drugs, pharmaceutical agents, diagnostic agents, clinical intervention (clinical examination in pharmacy). Addition (responsible conduct of clinical research, clinical research funding, budget control studies). Analysis and presentation of the results of clinical research. The translation in the pharmaceutical research and clinical practice.Practical Classes Building proposals clinical research in pharmacy - patient-oriented research. Finding research questions. Research goals, objectives, research questions and assumptions. Preparation of preliminary data. Review of literature (how successful literature review and data analysis). Research notes (research goals, objectives, mechanisms, research hypotheses, hypothesis testing whether you are measurable, ethical, important). Variables and their measurement. Human subjects in clinical research. Estimation of sample size. The development database. Data collection and quality control. Supervision of experiment intervention. The final suggestion of research in clinical pharmacy practice.Literature:

1. Prezentacije i dodatna literatura dostavlјena od strane nastavnika u toku nastave predmeta

2. Translational and experimental clinical research, authors: Daniel P. Schuster and William J. Powers, Lippincott Williams and Wilkins, 2005, ISBN 0-7817-5565-4.

Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: theoretic interactive lectures, analisys and disscusions, practical excercise.



BUSSINES ENGLISH

Study programs: pharmacy, pharmacy - medical biochemistry

Type and level of study: integrated academic studiesName of subject: Bussines EnglishTeacher: Subjects status: optionalSemester: fifth year, ninghth semesterECTS: 4Requirement: English in PharmacySubjects objective:The objective of this course is to master the specifics of business English, and learning phrase patterns necessary to communicate on a professional level and to master the techniques of written and oral expression in professional communication.Subjects outcome:The student will be able to apply the acquired knowledge in professional communication, create the appropriate written form in accordance with their professional communication and speech patterns adjusted to the situationSubjects content: Lectures CV, basic characteristics, models, components, rules of writing. Motivational letter. Job interview. Business correspondence: business letter, job application, response to an official letter, information search, writing the e-mail. Telephone communication on an official level. Business lunch, cocktail, festivity. Greeting. A chance meeting, a business meeting, a high level meeting, conference call, video conference call. Public speaking. Creating a business plan. Writing the analysis report. Writing a review of the scientific and professional texts (chemical, pharmaceutical, medical).Practical classesWriting: CV, motivational letter, business letter, job application, response to an official letter, asking the information, mail, business plan, analysis report, specialized text revue, professional scientific text. Oral interpretation: telephone communication on an official level, business lunch, greetings, meeting, business meeting, conference call, public address.Literature: 1. Baade Kate, Duckworth Michael, Grant David, Holloway Christopher, Hudson Jane, Hughes John, Naunton Jon, Scrivener

Jim, Turner Rebecca: Business Results, Oxford, 2009.2. Cotton David, Falvey David, Kent Simon: Market Leader, Longman, Harlow, 2001. 3. Field Marion: Improving Your Written English, 3rd ed., How To Books Ltd., McMilan, London, 2001.4. Poslovni tekstovi iz prakse (izbor).5. Komercijalni (revijalni) tekstovi o farmaceutskim proizvodima (izbor).6. Naučni stručni farmaceutski tekstovi (izbor).Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, practical exercises, e-learning.



ADICTION AND DROG ABUSE

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Adiction and Drug AbuseTeacher:Subjects status: optionalSemester: fifth year, ninghth semesterECTS: 4Requirement: Pharmacology, Neuropharmacology

Subjects objective:Acquisition, adoption, analysis, synthesis and application of knowledge of xenobiotics that cause dependence, divided into categories.Subjects outcome:Upon completion of the course, students will be able to: in the scientific terms deal with the problem of treatment with toxic assets that are addictive, determine the correct sample for toxicological analysis, sample preparation and analyzes, and interprets the output from the report and suggested antidote or other appropriate therapy.Subjects content:LecturesTheoretical classes: Social aspects and effects on health of addicts, historical overview of misuse of drugs which are addictive, legislation and national action plans for prevention of abuse of drugs which cause addiction. Chemistry and function of the CNS, toxicodynamics and toxicokinetics of addictive drugs, dependency theory, tolerance. Practical classesAlcohol and other volatile compounds. Heroin and other opiates. Cocaine, crack, amphetamines. Nicotine and caffeine. CNS depressants. Hallucinogens. Cannabis and cannabinoids. Anabolic steroids. Analysis of the mechanisms of toxicity, toxicokinetics, tolerance and dependence. First aid and treatment.Literature: 1 Preradović Miloje et al.: Addiction diseases, Military Institute, Belgrade, 2005.2 Joksović Dragan: Acute drug poisoning, textbook, Military Institute, Belgrade, in 1999.3 Thomas A. Gossel, J. Bricker Douglas: Principles of Clinical Toxicology, 3rd ed., Raven Press, New York, in 1994.4 Pedro Ruiz, C. Strain Eric G. Langrod John: The Substance Abuse Handbook, Williams & Wilkins, New York, 2007.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: interactive lecture, work in groups, pannel discusions, case study, field excersise.



DERMATOCOSMETICS PRODUCTS

Study programs: pharmacyType and level of study: integrated academic studiesName of subject: Dermatocosmetics ProductsTeacher:Subjects status: optionalSemester: fifth year, ninghth semesterECTS: 4Requirement: CosmetologySubjects objective:The aim of the course is training students on the category of dermocosmetic products that are highly represented in public pharmacies, learning about the legal regulations in the field of dermocosmetics in the EU, learning about the categorization of dermocosmetic products, acquisition of skills, identification of key ingredients in dermocosmetic products, their effects, and ability to provide appropriate advice on usage and possible side effects.Subjects outcome:After the exam, the student will be able to know the basic EU legislation and the recognition of the INCI names of ingredients of different groups of dermatological and cosmetic preparations; will have a basic knowledge of the characteristics, structure and processes of making the most important group of products; being able to assess their desired and potential side effect; will be able to use the correct terminology; being able to reliably transfer the information to a potential user; being aware of the trends in the field of dermocosmetics and methods of evaluation of their effects and quality.Subjects content:

LecturesDefinition, characteristics of dermatological and cosmetic products and differences in relation to cosmetics and medicines. Legislation in the EU and the U.S., with particular emphasis on regulations pertaining to the assessment of effects, safety and their tolerability. Mechanisms of aging and photo-aging, oxidative stress directions in the formula-tion of new products for the prevention and treatment of photo-aging. The ingredients in the formulation: antioxidants, a group of excipients. Modern carriers of CAS in dermocosmetic products. Dermocosmetic products for the preven-tion and treatment of skin aging. Dermocosmetic products for mature skin. Dermocosmetic products for skin protec-tion from the sun. Dermocosmetic products for baby skin care and baby skin. Dermocosmetic products for the treat-ment of scalp and hair. Practical classesDiscussion, analysis of market supply, the analysis of commercially available dermatological and cosmetic products, websites, comparative analysis and critical interpretation of dermatological and cosmetic products offer the same pur-poses in the Serbian market, visit of cosmetology study.Literature: 1. Čajkovac M.: Cosmetology, Naklada Slap, Zagreb, 2000.2. Milady: Milady’s Standard Cosmetology, Milady, London, 2011.3. Rieger M. M.: Harry's Cosmeticology, 8th ed., Chemical Publishing Co. Inc., New York, 2000.4. De Polo K. F. D.: A short textbook of cosmetology, 1st ed., H. Ziolkowsky GmbH, Augsburg, 1998.5. Cosmetics & Toiletries, Allured bisiness media, Carol Stream, IL 60188-2403.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, laboratory exercises, work in groups, practical classes, visiting of real workspace.



DIETETIC FOOD AND DIETARY SUPPLEMENTS

Study programs: pharmacy, pharmacy - medical biochemistryType and level of study: integrated academic studiesName of subject: Dietetic Food and Dietary SupplementsTeacher: Subjects status: optionalSemester: fiftth year, ninghth semesterECTS: 4Requirement: PhytotheraphySubjects objective:The aim of the subject is to get insight into dietary food and dietary supplements available in pharmacies, regulation in this field, as well as the possibilities to use these products in the prevention and treatment of various diseases.Subjects outcome:After finishing the course student will be able to provide information concerning application of dietary products in nutrition and diet, application of dietary supplements in treatment of various diseases; to analyze and critique product labels; help patients, clients or consumers about dosing, uses, side effects, warnings.Subjects content: Lectures Dietary food and dietary supplements – definition. Regulation concerning dietary food and dietary supplements. Classification. Functional food.Practical classes Dietary products market analyzing. Analyzing of supplements commercially available on the market. Internet presentations.

Comparative and critical analysis of similar dietary food and dietary supplements available on the domestic market. Food calorimetry. Selection of different dietary food and dietary supplements in specific nutritional requirements.Literature: 1. Hendler Sheldon, Rorvik David: Nutritional supplements, PDR Network, New York, 2008.2. Dijetetski suplementi na tržištu Srbije 2010. godine, Institut za bromatologiju, Farmaceutski fakultet, BD Soft, Beograd,

2010.3. Zbornik apstrakata, Treći Kongres o dijetetskim suplementima, Beograd, 2007.4. Gibson G. R., Williams C. M. (eds.): Functional Foods, William Andrew Publishing, Noyes, London, 2000.5. Zakonski propisi iz ove oblasti.Number of active teaching: Other classes:Lectures: 30 Exercises: 30 Other forms of teaching: Students research work:Methods of teaching: interactive lectures, practical exercises, e-learning.



· web viewtitle of study programme pharmacy educational-scientific / educational-art field...

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