webinar | real-time analytics for healthcare: how amara turned big data into big answers
TRANSCRIPT
How Amara Health Turned Big Data into Big AnswersChristopher Rosin, Ph.D. and Chief Scientist, Amara Health AnalyticsSeema Haji, Director of Product Marketing, DataStax
All attendees placed on mute
Input questions at any timeusing the online interface
Webinar Housekeeping
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Agenda• About Amara Health• Selecting the right database technology for real-time decisions• Evaluating NoSQL for Healthcare applications• Amara – real-time predictive analytics for patient-centric
excellence• Integrated analytics with DataStax Enterprise 4.5• Q&A
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About Amara Health
• Real-time predictive analytics to support clinicians in the early detection of critical disease states
• Early detection enables rapid response, driving better patient outcomes and lower healthcare costs
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Clinical Vigilance™ for
Sepsis
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Sepsis, and the Challenge of Early Identification • 800,000+/year contract sepsis in the U.S.; 250K-300K sepsis
deaths/year• $20+ billion annual cost to U.S healthcare providers• Mortality rate for septic shock exceeds 50%… and, untreated, grows
7.6% per hour“Evidence unwaveringly suggests that early administration of appropriate antibiotics reduces mortality…” (Surviving Sepsis Campaign)
"Lack of early recognition is a major obstacle to sepsis bundle initiation." (Surviving Sepsis Campaign, 2012 Guidelines)
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Real-time Decision Support• Clinical decision support software• Primarily a SaaS solution• Connects to existing hospital information
systems and analyzes all patient data 24/7• Supports early sepsis detection/prediction• Provides clinical alerts to smartphone/tablet• Technology:
• Machine Learning• Natural Language Processing• Auto-filtering of physiological signals
• Unique combination of early alerting with very low false positives
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Antibiotic Timing and Mortality• Retrospective study data: 36 months from 2 hospitals• Mortality & LOS for varying delay from Clinical Vigilance™ for Sepsis alert to IV
antibiotics For 2217 patients with moderate initial severity (PIRO score 5-
14)
0-3 hours 3-6 hours 6-12 hours 12-24 hours
24-48 hours
5
10
15
20Mortality %
0-3 hours 3-6 hours 6-12 hours 12-24 hours 24-48 hours456789
Median Length of Stay (days)
Earlier antibiotics after Clinical Vigilance™ for Sepsis alert are associated with better outcomes.
(Preliminary data from work by Dr. Ryan Arnold, Christiana Care Health System)
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The Challenge
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• Expanding and ever-changing data volumes and formats• A complex mix of structured and unstructured real-time data• Strict requirements on:
• Security and privacy (HIPAA)• Application uptime and response times • Real-time decision support• Reliability and data integrity
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Key Database Requirements
Strong real-time search and query capability
Support high reliability and security
Structured & unstructured real-time data
Flexible data model with affordable scalability
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Why NoSQL, Apache Cassandra, and DataStax Enterprise• Schema can change at run-time in real-time; dynamic columns• Strong search & real-time query capability on unstructured data (Solr
integration)• Supports 100% uptime through replication and rolling upgrades• Enterprise level security• 24x7 support• Open-source foundation• Community
Clinical Vigilance™ Input
DataAggregator
Hospital DataOver VPN
Cassandra
HL7 Interface Engine
ack
ack
HL7 Sources
Non-HL7 Sources
Raw & Transformed Data
Clinical Vigilance™ Server VM
…
Hospital data is extremely diverse and changes rapidly in structure and usage.
Clinical Vigilance™
dynamically adds new columns in real-time, in response to new fields observed in incoming data.
Data Protection and Replication
HIPAA-Compliant Data CenterOffsite Cassandra
VM A
Hospital A Hospital B
VM B
Cassandra 1
KSA
KSB
Cassandra 2
Authenticated
Authenticated
Hospital VPN terminates inside hospital-dedicated virtual machine
Each hospital has a separately authenticated Cassandra keyspace
On-site and off-site redundancy supported via Cassandra replication.100% uptime during rolling upgrades
VPNVPN
KSA
KSB
What is Apache Cassandra?
San Francisco
Stockholm
New YorkC*
C*C*
Open Source NoSQL DatabaseIndustry Leading Performance Predictable Scalability Geographical Data DistributionOperational Simplicity Business Flexibility
Security Analytics Search VisualMonitoring
ManagementServices In-Memory
Dev. IDE & Drivers
ProfessionalServices
Support & Training
Integrated analytics, OLTP, SearchIn-memory analytics and OLTPBuilt-in data protection
Production-ready CassandraMulti-workload, use case capableAutomated management services
©2014 DataStax Confidential. Do not distribute without consent.
What is DataStax Enterprise?
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DataStax Enterprise 4.5Integrated 100x faster analytics and operational simplicity
1. New analytics options for any workload and size• 100x faster analytics on real-time data with Spark• Seamless integration with Hadoop analytical systems • Hive compatible SQL-like language
2. New Performance Service drives operational simplicity3. Enhanced OpsCenter supplies greater ease of use and security
Modern online Web and Mobile applications have outgrown legacy RDBMS transactionsToday’s OLTP is more of an “interaction” needing customization via analyticsThe end goal is to influence the next action a customer takes on a website or mobile app
©2014 DataStax Confidential. Do not distribute without consent.
Transactional Analytics Transforms Businesses
OS Cassandra
DSEStandard
DSEPro
DSEMax
DATABASE MANAGEMENT / SERVICES
Advanced Security Option ✔ ✔ ✔In-Memory Option ✔ ✔ ✔Automatic Management Services ✔ ✔ ✔Enterprise Search ✔ ✔Integrated Analytics (Real-time and Batch via Hadoop) ✔MANAGEMENT
OpsCenter Basic Advanced Advanced AdvancedSUPPORT AND PROFESSIONAL SERVICES
Expert 24x7x365 Support ✔ ✔ ✔Platform certification ✔ ✔ ✔Certified service packs ✔ ✔ ✔Hot fixes ✔ ✔ ✔Bug escalation ✔ ✔ ✔Health checks/Performance reviews ✔ ✔ ✔Custom builds Option
Easy Upgrade Path with DataStax Enterprise
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Apache Cassandra
DataStax Enterprise
1) View Use Cases: /customers2) Attend Monthly Customer Webinars: /webinar3) Attend an Internet Enterprise Event: /events
1) Download DataStax Enterprise: /download 2) Get Trained: academy.datastax.com3) Attend a Tech Day: /events
Management IT
Technical IT
1) Download DataStax Community /cassandra2) 10 Minute Cassandra Walk Through /trycassandra3) Attend a Meet Up /join-your-local-meetup
Community
C*
On planetcassandra.org
On datastax.com
On datastax.com
How to Get Started?
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Thank You!