what are probiotics? commercially available microorganisms which, when ingested as individual...
TRANSCRIPT
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What are Probiotics?
Commercially available microorganisms which, when
ingested as individual strains or in combinations, offer potential health
benefits to the host
World Health Organization
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Main PROSPECT TrialResearch Question
In the mechanically ventilated, critically ill patient, what is the effect of enteral L. rhamnosus GG when compared to placebo on…
•Ventilator Associated Pneumonia•Other ICU-acquired infections•Diarrhea (total, antibiotic associated and Clostridium difficile-associated diarrhea)•Antibiotic use•Duration of mechanical ventilation•ICU and hospital length of stay•ICU and hospital mortality
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Inclusion Criteria– Adults ≥18 years – Admitted to ICU and invasively mechanically ventilated– Anticipated ventilation of ≥72 hours
Exclusion Criteria– Invasively mechanically ventilated > 72 hours– Risk factors for iatrogenic infection
• Specific immunocompromized populations• Patients at risk for endovascular infection • Patients with a primary diagnosis of severe acute pancreatitis• Patients with percutaneous gastric or jejunal feeding tubes
already in situ
– Strict contraindication or inability to receive enteral meds– Life support limitation– Previous enrolment in this or current enrolment in a potentially
confounding trial
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PROSPECT Administration Supplies
•Tap Water•Catheter Tip Syringe (60ml)•Specimen Container (80ml) •Nasogastric Feeding Tube