Attacking the sources of aging, not just the

signs and symptoms.

WHAT IS ageLOC?

SISTERS? OR MOTHER/DAUGHTER?

ageLOC HELPS EXPLAIN…

Why Some People Look Years Younger

Than They Really Are.

EVOLUTION OF AGELOC:

HUMAN GENOME

• Mapping of the human genome

• 2003 discovery after 20 years of research: 20,000 – 25,000 genes form

the human genome

• Twenty Labs with hundreds of scientists (United States, the United

Kingdom, France, Germany, Japan and China)

• $3 billion

WHAT DOES THIS

TELL US ABOUT AGING?

…………………tgactgccaatttgccaataccaattattgggggaatatgcccaatatatgcccgag

accagtattatgactgccaatttgccaataccaattttggcgactggaatatgcccaatatatgcccgagacc

agtattatgactgccaatttgccaataccaattttggacgaatatgcccaatatatgcccgagaccagtattat

gactgccaatttgccaataccaattttgggtgaatatgcccaatatatgcccgagaccagtattatgactgcc

aatttgccaataccaattattgggggaatatgcccaatatatgcccgagaccagtattatgactgccaatttg

ccaataccaattttggcgactggaatatgcccaatatatgcccgagaccagtattatgactgccaatttgcca

ataccaattttggacgaattatatgcccgagaccagtattatgactgccaatttgccaataccaattttggacg

aatatgcccaatatatgcccgagaccagtattatgactgccaatttgccaataccaattttgggtgaatatgc

ccaatatatgcccgagaccagtattatgactgccaatttgccaataccaattattgggggaatatgcccaat

atatgcccgagaccagtattatgactgccaatttgccaataccaattttggcgactggaatatgcccaatata

tgcccgagaccagtattatgactgccaatttgccaataccaattttggacgaatatgcccaatatatgcccga

gaccagtattatgactgccaatttgccaataccaattttgggtgaatatgcccaatatatgcccgagaccagt

attatgactgccaatttgccaataccaattattgggggaatatgcccaatatatgcccgagaccagtattatg

actgccaatttgccaataccaattttggcgactggaatatgcccaatatatgcccgagaccagtattatgact

gccaatttgccaataccaattttggacgaatatgcccaatatatgcccgagaccagtattatgactgccaattt

gccaataccaattttgggtgaatatgcccaatatatgcccgagaccagtattatgactgccaatttgccaata

ccaattattgggggaatatgcccaatatatgcccgagaccagtattatgactgccaatttgccaataccaatt

ttggcgac…………..……3 billion base pairs…….…

NU SKIN’S AGING EXPERTISE

LIFEGEN PARTNERSHIP

Dr. Richard Weindruch

Professor of Medicine

University of Wisconsin

Dr. Tom Prolla

Professor of Genetics

University of Wisconsin

STANFORD COLLABORATION

• Stanford University

• Two Dermatology Professors

– Howard Chang, MD, PHD

– Anne Chang, MD

• Professor of Genetics

– Stuart Kim, PhD

Published over 300

scientific papers, and

their insights have

changed the way aging

is viewed

Anti-Aging experts

NU SKIN SCIENCE

1. Gene activity in skin

2. How did we discover YGCs?

3. How do YGCs influence skin?

4. ‘Resetting’ YGCs

OUR SPACE IN THE GENE WORLD: DEFINING YOUTH GENE CLUSTERS

GENE ACTIVITY IN SKIN

DNA Microarray Gene Map

Over 20000 Genes

DNA

Microarray

Heat Map

4 YGCS IDENTIFIED

TIMP1 COL7A1

AQP3

IL1B

PPARG

TNFA

POMC

IL1B

IL6

SOD2

MT2A

TXNRD1

Pigment

20+ GENES

Cell Turnover

35+ GENES

Hydration

20+ GENES

Skin

Structure

60+ GENES

Texture, Smoothness

Radiance

Pore Size

Hydration

Discoloration

Skin Tone

8 Signs of Aging

Fine Lines & Wrinkles

Youthful Skin

Structure

Youth Gene Clusters

Pigment

Hydration

Cellular Turnover

ageLOC Science

Skin Structure

YGCs LINKED TO SIGNS OF AGING

ageLOC RESET

YGCs

DOWN UP

IT’S ABOUT BALANCE

Genes preserving youthfulness Genes accelerating aging

Down regulation Up regulation

GENE 1

GENE 2

GENE 3

GENE 4

GENE 5

GENE 6

GENE 1

GENE 2

GENE 3

GENE 4

GENE 5

GENE 6

REBALANCING YGCs

Youth Gene

Cluster Youth Gene

Cluster

FINDINGS PUBLISHED DEC 2009

DOWNLOAD SCIENTIFIC POSTER –

PUBLISHED DEC. 2009

FINDINGS PATENTED

• The ageLOC science or the

ingredients in the ageLOC products

are protected by 14 patents that have

been approved or are in stages of the

review process with Patent and

Trademarks Offices in multiple

countries

ageLOC SCIENCE

KEY MESSAGE POINTS

1. ageLOC science targets the ultimate sources

of aging

2. ageLOC science identifies Youth Gene

Clusters

3. ageLOC science resets Youth Gene Clusters

to more youthful patterns of activity

LOOKING AHEAD

THE FUTURE: PHARMANEX AGELOC

Exclusive anti-aging research

and product innovation

coming Fall 2010!

• Attack sources of aging

internally

• Extend ageLOC technology

to include nutrition

1. Attacks aging at its source – genes

2. Youth gene clusters identified in skin and linked to

clinical skin attributes

3. Resets YGCs restores skin

4. Findings published and protected by 14 patents and

patent applications around the world

5. Nu Skin’s future products will address aging

incorporating key insights from experts

A TRULY TRANSFORMATIONAL

EXPERIENCE

• Gentle Cleanse & Tone

• Radiant Day

• Transforming Night

• Future Serum

ageLOC

GENTLE CLEANSE & TONE

• Prepares the skin to

receive advanced

anti-aging ingredients

and ageLOC

• Delivers the first

infusion of ageLOC

to the skin

• Most advanced product in Nu Skin history

• Maximum concentration of ageLOC

• ageLOC & other Anti-aging ingredients proven to improve skin in 8 ways

ageLOC

FUTURE SERUM

ageLOC

RADIANT DAY SPF 22

Infused with ageLOC and other

advanced anti-aging ingredients

proven to:

• Increase radiance, reduce

discoloration through

melanin inhibition

• Increase cell turnover by

85%

• Reduce fine lines, wrinkles

& pores

• Dramatically smooth and

soften skin

ageLOC

TRANSFORMING NIGHT

Infused with ageLOC and other advanced

anti-aging ingredients proven to:

• Work with skin’s natural nighttime repair

and renewal processes, strengthening

natural barriers

• Increase youthful cell turnover by 85%

• Reduce look of fine lines, wrinkles &

pores

• Dramatically smooth and soften skin

100%

BEST RESULTS

of the subjects started

showing improvements in

two or more signs of aging

in only 7 days based on

clinical assessments.

► 12-week clinical study

► Consumer Perception

& Blinded Clinical

Graders

► Improvement in 8

different signs of aging

► The best results we’ve

ever seen at Nu Skin

Consumer Perception

THE PROOF

Consumer Perception

80%

THE PROOF

The Anti-Aging

Master

Simple – Powerful!

GALVANIC SPA® II FACIAL GELS

CONFIRM: New genomic

research confirms that ageLOC

Facial Gels reset Youth Gene

Clusters in addition to slowing

arNOX enzyme.

PRE-TREAT GEL

Product Benefits

Pre-Treat Gel with the ageLOC™

Face Conductor helps remove skin

impurities and let your pores

‘breathe’.

Key Ingredients

• Marigold extract, sea kelp and vanilla

extract— soothe and condition the

skin.

• Cocoyl Glutamate—purifies the skin.

TREATMENT GEL

Product Benefits

Treatment Gel with the ageLOC Edition

Galvanic Spa™ Face Conductor

revives and invigorates your skin.

Key Ingredients

• ageLOC—a patent-pending ingredient

technology that targets Youth Gene

Clusters, the ultimate sources of aging.

• Arginine—an amino acid which helps

the skin to recover from stress

• Magnesium—a necessary component

that promotes cellular energy

HOW DOES IT WORK?

HOW DOES IT WORK?

AGELOC EDITION GALVANIC SPA™

Delivers up to 5X’s more

ageLOC ingredients to

the skin than the original

Galvanic Spa System II.

• Larger, brighter display

• Intuitive usability

• Enhanced ergonomics

• Redesigned circuit board

provides optimized

current flow.

AGELOC EDITION GALVANIC SPA™

LASTING BENEFITS

Nu Skin’s patent pending

discovery, based on carefully

controlled research, reveals

that treatment with a galvanic

instrument may enhance the

delivery of key ingredients for

up to 24 hours. This includes

active ingredients contained in

subsequently applied

treatment products.

NEW ageLOC GALVANIC SPA TOTE

GO MOBILE!