Natural Astaxanthin May ImproveGastric HealthThe digestive system is one of the most sensitive components of the human body. A healthy digestive system plays an important role in a healthy lifestyle. Many common gastric ailments and their symptoms, such as dyspepsia, irritable bowel syndrome (IBS) and Crohn´s Disease, are characterized by inflammation of the stomach and/or intestine.

Gastric inflammation and stomach pain can also be caused by an infection such as Helicobacter pylori (H. pylori). Pathological symptoms of H. pylori infection include high levels of oxidative stress and inflammation of the stomach lining and symptoms such as gastric pain and acid reflux.

Natural astaxanthin is both a powerful antioxidant and a potent anti- inflammatory. Clinical studies have shown that astaxanthin supplementation can support gastric health due to its ability to inhibit gastric inflammation, provide protection against stomach ulcers and reduce H. pylori infection.

What is Natural Astaxanthin?It is a naturally occurring carotenoid which is derived from the microalgae Haematococcus pluvialis. As well as being the most powerful antioxidant known to science, it also has potent anti-inflammatory properties. Natural astaxan-thin’s distinct advantage in comparison to other anti-oxidants, is its ability to span the entire lipid bilayer of the cell membrane, thus providing superior protection from the inside out. Natural astaxanthin has been shown to improve brain and cognitive health.

Research & Key FindingsNumerous clinical studies support natural astaxanthin as beneficial for stomach health. In a pilot trial, ten patients with H. pylori infection took natural astaxan-thin and found considerable relief from indigestion symptoms like heartburn (1). Based on these posi-tive findings, researchers followed up with a larger double-blind study. In this study different dosages of astaxanthin (16 mg or 40 mg) were compared to placebo in a group of 131 adults with dyspepsia over a four-week period. The higher dosage of astaxanthin significantly reduced the symptoms of heartburn and this effect was most pronounced in the patients found to be infected with H. pylori (2).Figure 1. Natural Astaxanthin Reduces Gastric Reflux AstaReal® astaxanthin 40 mg/kg AstaReal® astaxanthin 16 mg/kg Placebo

AstaReal® reduced reflux-syndrome score (GSRS Score) of dyspepsia patients treated with 40 mg daily astaxanthin (*p<0,05 compared with control) (2).

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AstaReal® Keeps YourStomach HappyBenefits of Natural Astaxanthin forStomach Health

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AstaReal® Decreased Total Clinical Symptoms

Forumvägen 14, SE-131 53 Nacka, SwedenPhone +46 (0) 8 5701 3950, Web: www.astareal.se, Email: info@astareal.se

Copyright 2018 AstaReal®. Information found is presented in good faith with no guarantee as to accuracy and no assumption of liability. This document contains material protected under International Copyright Laws and Treaties. Any unauthorized reprint or use of this material is prohibited. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system without express written permission from the author/ publisher. he information provided in this brochure is intended for business to business, educational purposes only and should not be used as medical advice. The statements herein have not been evaluated by the EFSA. The products described are not intended to diagnose, treat or prevent any disease.

AstaReal® – The Most Studied BrandThe AstaReal Group is recognized as an authority in natural astaxanthin science and research. AstaReal´s high quality natural astaxanthin is the most studied form of the nutrient worldwide. The clinical data-base for AstaReal® includes 60+ clinical trials with more than 1400 participants undergoing treatments lasting from 2 weeks to 6 months.

Superior Product RangeAstaReal AB offers a range of bulk products to fit different formats, allowing for the development of innovative products that add astaxanthin’s unsurpassed antioxidant power. In addition, AstaReal AB has developed a range of finished formulations containing AstaReal® natural astaxanthin, each expertly developed to support a number of health areas.

References & Selected Natural Astaxanthin Publications 1. Lignell Å et al. 12th International Carotenoid Symptosium,

Cairns, 1999. 2. Kupcinskas el al. Phytomedicine. 2008;15:391-399. 3. Wetscher GJ et al. Am J Surg. 1995;170(6):552-556. 4. Yasui Y et al. Chemico Biological Interactions. 2011;193:79-87. 5. Bennedsen et al. Immunol Lett. 1999;70(3):185-189. 6. Wang et al. Antimicrob Agents Chemother. 2000;44(9):

2454-2457. 7. Kamath BS et al. Eur J Pharmacol. 2008;590:387-395. 8. Kim JH et al. Eur J Parmacol. 2005;514(1):53-59. 9. Kim JH et al. Biosci Biotechnol Biochem. 2005;69(7):1300-1305. 10. Yang Q et al. Yao Xue Xue Bao. 2009;44(5):558-560. 11. Bennedsen M, Wang X, Willen R. Treatment of H. pylori infected

mice with antioxidant astaxanthin reduces gastric inflamma-tion, bacterial load and modulates cytokine release by spleno-cytes. Immunol Lett. 1999. 70: 185-189.

12. Kupcinskas L, Lafolie P, Lignell A, Kiudelis G, Jonaitis L, Adamonis K, Andersen LP, Wadstrom T., Eficacy of the natural antioxidant astaxanthin in the treatment of functional dyspep-sia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study. Phytomedicine 2008. 15: 391–399.

13. Lignell A, Surace R, Bottiger P, Borody TJ. Symptom improve-ment in Helicobacter pylori positive non-ulcer dyspeptic patient after treatment with the carotenoid astaxanthin. In: 12th International Carotenoid Symposium, Cairns, Australia, 18-23 July 1999.

14. Wang X, Willen R, Wadstrom T. Astaxanthin rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrob Agents Chemother. 2000. 44: 2452-2457.

Benefits of Natural Astaxanthin for Stomach Health: Lowers gastric inflammation

Decreases infection of Helicobacter pylori

Reduces clinical symptoms in dyspepsia patients

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Figure 2. Decreased Total Clinical SymptomsAstaReal® reduced total grade of clinical symptoms in dyspepsia patients. Low symptom score continued 28 days after treatment was finished (1).

Intake of AstaReal® for 21 days