what risks do these pollutants pose to us? to determine this we need to understand the following
TRANSCRIPT
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What risks do these pollutants pose to us?
To determine this we need to understand the following
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Risk = Exposure x Harm• Risk
– Possibility of suffering from a hazard that causes harm, disease, economic, or environmental loss
• Risk assessment– Identifying hazards – Determine probability– Assess severity
• Risk Management– Determine seriousness– How can it be reduced?– How much should we spend?
• Probability– Likelihood that an event
or effect will occur
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Types of Risks
• Cultural• Physical • Biological • Chemical
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Biological Hazards
• Non-transmissible– Not spread through
living organisms– Cannot be spread
between contact– Examples
• Asthma• Heart disease• cancer
• Transmissible– Can be spread through
living organisms– Examples
• AIDS• Malaria• STD
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• Viral Diseases– Ability to adapt and
evolve– influenza = largest threat
because it is airborne and highly contagious
• Sexually Transmitted Diseases– 23% of Americans have
an STD and don’t know it
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Biological Risks Cause Disease:• Chronic Disease:
– slowly impair body function– Cancers, diabetes, heart disease, obesity
• Acute Disease:– Rapid onset– Ebola, flu
• Infectious Disease:– Caused by pathogens– STDs, flu, cold, viruses, protist infections, fungi
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2011 Data
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Various Biological Risks
• Will be filled in via class powerpoint slides
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Toxicology: The study of chemical risk• Toxicity: measure of harmfulnessChemicals Sources Impact
Neurotoxins Lead, mercury Disrupt nervous system, paralysis, impaired learning
Carcinogens Asbestos, radon, tobacco, PCBs, formaldehyde
Cause cancer and cell damage
Teratogen Thalidomide, alcohol, heavy metals
Impair fetal developmentBirth defects
Allergens Penicillin, codeine, dander Trigger immune response
Endocrine disruptors
Pharmaceuticals, atrazine herbicide, DDT, insecticides, phthalates in cosmetics and plastics
Impair hormone functionsDecrease sperm countGender benders
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Toxicology: the study of toxins
• Toxicity – measurement of how
harmful a substance is
• Dose– Amount of a substance
that is absorbed, inhaled, ingested
• What impacts the effect of a toxin?– Size of dose over given
time– Who is exposed to dose
• Genetic makeup• Body detox system
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Factors that impact dose:
• Solubility– Water soluble
• Acids, salts
– Oil / fat soluble• Pesticides, PCBs, mercury,
metals
• Persistence– Ability to withstand
breakdown– Persistent Organic
Pollutants• Pharmaceutical medicines• pesticides
• Bioaccumulation– Molecules are absorbed
and stored in organs and tissues of single organism
• Biomagnification– Toxins increase as they
move through food chain
• DDT
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Various Chemicals that cause long term harm (poisoning)
• Will be addressed in class PowerPoints
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5. Chemical Interactions
• Antagonistic: Decrease in harm when mixed– Chemicals to prevent
anticoagulation– Dimercaprol: treats
arsenic, mercury, lead poisoning
– Bretylium: adrenaline blocker
– Prozac: blocks 5HT receptors
• Synergistic: Combined effect increases harm more than either by themselves– Asbestos + smoking– Smoking and birth
control
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Response to Toxins
• Chronic Effect– Permanent and long
lasting• Radium Girls• Smoking• Lead or mercury poison
• Acute effect– Immediate harmful
reaction• Overdose to drugs• Running leads to
increased heart rate
Response = type and amount of health damage due to exposure
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QUESTION:
Because there is variation within a population. When we are using risk management, who should we protect? The most sensitive or the average?
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Toxicity
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Lethal Dose• LD50
– Lethal dose • Amount of chemical needed for
50% of the population of animals in test population to die within 14 days.
• LC50
– Lethal concentration• Concentration needed to cause
death to 50% within 14 days.
• Poison– Chemical with an LD50 of
50mg or less per kg body weight
100
75
50
0 2 4 6 8 10 12 14 16
Per
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by a
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ose
Dose (hypothetical units)
LD50
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DOSE RESPONSE CURVES
Graphs that show the effects of various dosages of a toxin on a group of test organisms.
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Nonthreshold dose response
• Any dosage causes harm with an increase in dose.
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Threshold Dose Response
• A threshold must be met before detectable harmful effect
• Medicines• Water