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Kathleen Casey-KirschlingBorn January 1, 1946

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YOUNG CHILDREN AND OLDERPEOPLE AS A PERCENTAGE OFGLOBAL POPULATION

PROJECTED INCREASE IN

GLOBAL POPULATION

BETWEEN 2005 and 2030,

BYAGE

United Nation Department of Economic and Social Affairs, Population Division.World Population Prospects. The

2004Revision. New York: United Nations, 2005 in Why Population Aging Matters: A Global Perspective at

www.nia.nih.gov/ResearchInformation/ExtramuralPrograms/BehavioralAndSocialResearch/GlobalAging.htm

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Increases in Life Expectancy

8

7.

77.8

Nean

erta

assic

a me

Meiev

a En

an

U..(

)

rrentU. .

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Age and Risk of Chronic Disease

Source: National Vital Statistics Report, Vol 50, No 15, Septe ber 16, 2002

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Alzhei ers Disease Projections: Incidence,Cost of Care, and Federal Research Funding

Sources: Alzhei ers Study Group, A National Alzheimers Strategic Plan: The Report of the Alzheimers Study Grouparch 2009 ; Alzhei er's Association, Changing the Trajectory of Alzheimer's Disease: A National Imperative ay 2010 ;

National Institutes of Health Office of the Budget website

People in US withAlzheimersCost of Care

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Treat ents in De elop ent:Nearly 100 for Alzhei ers and other De entias

Source: PhRMA New Medicines in Development forNeurological Disease (November2010)

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Select Failed Alzhei ers DiseaseTreat ent Trials

Treatment Result

Di ebon Negati e

Rosiglitazone Negati e

Se agacestat Negati e

Tarenflurbil Negati e

Tra iprosate Negati e

Xaliprodan Negati e

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Lifecycle of Alzhei ers Disease:Where We Inter ene

Source: Jack et al, Brain 2009

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Lifecycle of Alzhei ers Disease:Where We Inter ene

Source: Jack et al, Brain 2009

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Lifecycle of Alzhei ers Disease:Where We Inter ene

Source: Jack et al, Brain 2009

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Alzhei ers Disease Treat entDe elop ent

Pro ising bio arkers:

Amyloid Imaging

CSF Proteins

Genetics

Volumetric MRI and Hippocampal Shrinkage

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Getting FDA to Respond

Alzhei ers Disease Bio arkerWorking Group

Dennis Selkoe (Harvard), Co-Chair John Morris (Wash U., St. Louis), Co-Chair

Cliff Jack (Mayo), Structural Neuroimaging Bill Klunk (Pittsburgh), Amyloid Imaging Reisa Sperling (BWH/Harvard), FMRI Dave Holtzman (Wash U., St. Louis), CSF Marliyn Albert (Johns Hopkins), Cognitive testing

Richard Mayeaux (Columbia), Genetics Paul Aisen (UCSD/ADCS), Clinical trials Eric Reiman (U. Ariz., BannerHealth), FDG PET John Trojanowski (Penn), ADNI core

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Getting FDA to Respond

e bers

Alliance for Aging Research (AAR) Alzheimer's Foundation of America (AFA) American Society on Aging (ASA) National Alliance forCaregiving (NAC) National Association of Area Agencies on Aging

(n4a) National Consumers League (NCL) Research!America Society forWomen's Health Research

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Getting FDA to Respond

e bers ContAbigail Alliance

Academy ofCorrectional Health Professionals

Alzheimers Drug Discovery Foundation

American Academy of Ambulatory Care Nursing (AAACN)

American Academy of Neurology

American Association for Geriatric Psychiatry (AAGP)

American Association ofColleges of NursingAmerican Federation for Aging Research (AFAR)

American Health Assistance Foundation

American Medical Students Association (AMSA)

American Medical Women's Association (AMWA)

American Nurses Association (ANA)

American Psychological Association (APA)

American Public Health Association

American Society ofConsultant Pharmacists (ASCP)Association of Jewish Aging Services (AJAS)

B'nai B'rith International

Blanchette Rockefeller Neuroscience Institute

Business and Professional Women/USA

Center for the Advancement of Health

FasterCures

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Getting FDA to Respond

e bers ContGerontological Society of America (GSA)

Hadassah

International Eye Foundation (IEF)

International Longevity Center - USA (ILC-USA)

Men's Health Network (MHN)

National Academy of Elder Law Attorneys

National Asian Pacific Center on AgingNational Association for Home Care

National Association of SeniorCompanion Project Directors

National Business Group on Health

National Commission on Correctional Health Care

National Council on Patient Information and Education (NCPIE)

National Electrical Manufacturers Association (NEMA)

National Indian Council On Aging

National Mental Health AssociationNational Palliative Care Research and Training Center(NPCRTC)

National Partnership forWomen & Families

National SeniorCitizens Law Center

National Women's Health Network

OlderWomen's League (OWL)

RetireSafe

Strategic Health Policy International (SHPI)

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Getting FDA to Respond

Other ajor Efforts:

Alzheimers Disease Neuroimaging Initiative(ADNI)

Coalition Against Major Diseases (CAMD)

NIA-Alzheimers Association Project toRedefine Diagnostic Criteria for AlzheimersDisease

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More About the Science of Alzhei ersDisease

Published in July 2010. Available by contacting: erose@janimm.com or gwen.fisher@pfizer.com

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