818 B o o k R e v i e w s

be a valuable source book, but evelt for those, who are interested mailtly ill other branches of bioenergetics, at least some of the chapters (e.g., considerations on the efficiency of l ight energy t ransformat ion and relevance of model reactions) can be highly recommended.

H. METZNER

A. A. BUEHLMANN and E. R. FROESCH, Pathophysiology, Springer Verlag, Berlin, Heidelberg, New York (I979), x l i + 4 o 3 pp., DM 39.5 ° / U S $ 22.20.

For all those embarking on medical studies this volume provides a well coordinated summary of the most impor tan t aspects of the pathophysiology of the various organs and apparatus. The clear descriptions in the first par t of each of the twelve chapters provide a basis for the unders tanding of the function of the s t ructure under consideration. The second part deals with fundamenta l pathological modifications in the structures. The topics discussed are the bron- chioles and respiration, the cardio-circulatory, digestive and ur inary apparafus, nervous and endocrine systems, and blood, bone and calcium metabolism. The chapters on water and electrolyte balance and metabol ism in general are par- t icular ly well prepared. Perhaps more space might have been dedicated to topics such as the regulat ion of body tempera tu re and acid-base balance. On the other hand in a 35o-page book one could not expect to find very detailed descriptions, nor in fact was this the aim of the volume, which was prepared pr imari ly for those commencing studies in medicine. In this respect it gives an excellent basis for such studies and will be of great help to the student. The tex t is clearly i l lustrated and completed by a comprehensive subject index.

L. SILVESTRONI

W. J. GEHRING (Editor), Genetic Mosaics and Cell Differentiation. Vol. 9 of the Series <~ Results and Problems in Cell Differentiat ion ~>, Springer Verlag, Berlin, Heidelberg, New York (I978), x I + 3 I 5 pp., DM 98 / US $ 53.90.

The in t roduct ion of techniques for generat ing genetic mosaics and ex- per imental chimaeras as an analyt ical tool in developmenta l genetics and experi- menta l embryology resulted in decisive progress with respect to determinat ion, cell lineage and cellular interactions during development . The most favourable species in analyzing these processes are Drosophila and the mouse.

This book is dedicated to this subject and contains ten papers, each wr i t ten by an exper t well known for significant contr ibut ions to this field of research. The authors have succeeded not only in presenting their own resuits in a very interest ing manner, but also in summariz ing all the essential experiments carried out up to 1977 on related subjects. By cri t ically discussing the methods, results and in terpreta t ions from various points of view, this book provides highly wel- come comprehensive reviews of research in this field.

W. JANNING shows the ways in which analyses of gynandromorphs result in tile es tabl ishment of blas toderm fate maps in Drosophila, and thereby provide an expansion of the knowledge of embryogenesis and development . I~I. J. BECKER

Book Reviews 819

describes the basic features of mitot ic recombinat ion relat ing to the analysis of development in Drosophila. K. ILLMENSEE gives an excellent account of the power of microil l jection techniques to trace phenotypical ly the origin and fate of cells and their clonal descendants during early embryonic development of Drosophila, especially in analysing the developmenta l potency of t ransplanted nuclei, cell commi tmen t and de terminat ion and the nucleo-cytoplasmic interac- tions during cellular diversification. The use of gynandromorphs and mitot ic recombina t ion in the analysis of pr imordial cell numbers in Drosophila imaginal discs and histoblasts is subject of the paper of J. R. MERRIAM.

E. WIESCHAUS presents detailed data on the origin, de terminat ion and .early development of imaginal discs (especially those of the thorax) by means of twin spot and minute analysis and discusses these results in relat ion to those obtained from other types of mosaics. His paper also deals with the question of the ex ten t to which these results are representa t ive of all regions of the embryo.

The paper (~ Cell Lineage and Differentiat ion in Drosophila ~) by A. GARClA-- BELLIDO and P. RIPOLL deals with genetic control of differentiat ion and mor- phogenesis and pa t t e rn formation, inasmuch as they discuss, singling out of genetic information in individual cells and their phenotypic realization in supra- cellular terms during development . The role of genes in pa t te rn format ion is also the subject of the paper of C. TOKUNAGA, which stresses the p re -pa t t e rn hypothesis ,

J. C. HALL gives a comprehensive survey of the applicat ion of genetic mosaics in the examinat ion of basic features of the development and function of parts of the nervous system tha t are, ill the broadest sense, responsible for behavior. R. L. GARDNER and A. MCLAREN give a very interest ing account .of the power of the application of genetic mosaic approaches in mammals . R. L. GARDNER provides a critical review and careful in terpre ta t ion of data ,concerning de terminat ion in the early embryo, subsequent differentiat ion within the t rophec toderm and inner cell mass and the retrospect ive analysis of precursor cell numbers and lineage relationships between tissues. This review is pr imari ly based on results obtained by the elegant technique of inject ing cells into mouse blastocysts. A. MCLAR~N'S paper very interest ingly illustrates the consequences tha t result from influencing the normal ly strongly canalized sexual deve lopment in p r imary and secondary as well as spontaneous and induced chimearas and mosaics of mammals , especially mice. She pr imari ly discusses the de te rmina t ion of phenotypic sex and the fate of germ ceils in sex chimaeras.

GEHRING'S book can be recomended to all people interested in develop- menta l b io logy; it will be read with much profit.

K. BECKER

IF. E. HAHN, Antibiotics, Vol. 5, Part. I and 2, Springer Verlag, Berlin, Heidel- berg, New York (1979), 846 pp., DM 324 / US ~ 178.2o.

This, the fifth volume in the series Antibiotics contains a description in the first par t of the mechanisms of action of ant ibacter ia l agents, and in the second par t of ant ieukaryot ic and ant iviral compounds. Each par t includes abou t 20 compounds, for each of which the chemical s t ructure , ac t iv i ty spec-